SUGA Hiroyuki 菅弘之

Researcher Number	90014117
External Links
Affiliation (based on the past Project Information) *help	2008: 国立循環器病センター研究所, 所長 2000 – 2006: 国立循環器病センター研究所, 所長 2005: 国立循環器病センター(研究所), 所長 2001 – 2002: 国立循環器病センター, 研究所, 所長 2001: 国立循環器病センター, (研究職)研究所長 … More 2001: 岡山大学, 大学院・医歯学総合研究科, 教授 1992 – 1999: 岡山大学, 医学部, 教授 1991: Okayama University Medical School, 2nd Dept. of Physiology, Professor, 医学部・第2生理学, 教授 1989 – 1990: National Cardiovascular Center Research Institute, Department of Cardiovascular Dynamics, Chairman, 循環動態機能部, 部長 1988: 国立循環器病センター研究所, 循環動態機能部・循環動態機 1987: National Cardiovascular Center Research Institute, Director, 循環動態機能部, 部長 1986: 循病セ, その他, 研究員 Less
Review Section/Research Field	Principal Investigator General physiology / Biomedical engineering/Biological material science / Circulatory organs internal medicine / General physiology Except Principal Investigator Biomedical engineering/Biological material science / Circulatory organs internal medicine / Anesthesiology/Resuscitation studies / Circulatory organs internal medicine / Biomedical engineering/Biological material science / 麻酔学 / 広領域 / Thoracic surgery / Thoracic surgery
Keywords	Principal Investigator Emax / 酸素消費量 / 心臓 / 興奮収縮連関 / 収縮性 / カルシウム / PVA / 期外収縮 / 心室 / 心筋 … More / 再循環率 / 期外収縮後収縮性増強 / 不全心 / postextrasystolic potentiation / excitation-contraction coupling / 心力学 / 収縮機構 / 収縮 / カルシウムハンドリング / oxygen consumption / 筋小胞体 / 統合生理学 / ryanodine / stunning / 機械的エネルギー / 心室容積 / 心室内圧 / 心収縮性 / 心エナジェティクス / 心室振動 / 心臓容積弾性率 / 心臓エネルギー / 弛緩 / 振動 / 無駄サイクル / 病的心 / 統合生理 / 一過性収縮性増強 / 心機能 / アルテルナンス / アルテナンス / 興奮収縮連 / エネルギー収縮 / クロスブリッジ / 興奮収縮率 / エネルギー効率 / 心筋細胞 / カルシウムトランジェント / エネルギー消費量 / 重奮収縮連関 / cardiac myocyte / calcium transient / excitation-contraction coupling. / energy consumption / 左心室 / 強心薬 / ピモベンダン / ペントバルビタール / left vantricle / cardiotonic agent / pimobendan / pentobarbital / Emaxの酸素コスト / 心筋スライス / falling heart / beat constant / recirculation fraction / total Ca^<2+> handling / リアノジン / カルシウムパラドックス / スタンド心 / 血液交叉灌流摘出心臓標本 / 収縮期末圧容積関係 / 収縮期末圧容積面積 / エネルギー変換効率 / 生体位心 / 心機能の評価 / メカノエナジェティクス / カルシウム動態 / heart failure / calcium paradox / sarcoplasmic reticulum / 心筋細胞Ca動態 / 一過性交互脈 / 心筋酸素消費 / 心筋メカノエナジェティクス / myocardial CaィイD12+ィエD1 handling / transient alternans / tailing heart / 心臓・心筋・エネルギー効率 / 収縮期圧容積面積 / エナジェティクス / 効率 / 圧容積図 / ATP / heart / myocardium / energy efficiency / syslolic pressure-volume area / mechanical energy / oxygen consumplion / 循環 / ポンプ機能 / 機械的効率 / 最適性 / 酸素消毒量 / 全容積面積 / Heart / Myocardium / Circulation / Pump function / Contraction / Contractility / Mechanical efficiency / Optimality … More Except Principal Investigator 放射光 / アクチン / ミオシン / 冠微小循環 / SPring-8 / フィジオーム / X線回折法 / クロスブリッジ動態 / 心筋酸素消費量 / 冠循環 / mechanical stress / 心不全 / 外科治療 / 左室形成術 / Heart Failure / LV repair surgery / fentanyl / Emax-PVA-Vo_2関係 / cardiac mechanoenergetics / ゲノーム / 機能的生体制御 / 生体テンセグリティ / データマイニング / マイクロイメージング / バイオニック医療 / マイクロメカニクス / 心筋 / レーザ回折法 / 乳頭筋 / スターリング機構 / 分子立体構造 / 心筋収縮タンパク質 / 小角散乱 / ナノテクノロジー / 高血圧ラット / 心肥大 / 心筋収縮タンパク / ミオシン間距離 / βアドレナリン受容体刺激 / リアノジン / 細胞内Ca^<2+>放出機構 / 生体内拍動心臓 / ラット / アクチン・ミオシン架橋 / 収縮性 / エナジェティクス / ドブタミン / 局所心筋 / 心臓力学 / 心機能 / 心筋収縮 / 交叉灌流 / 冠血流量 / Myocardial oxygen consumption / Contractility / Myocardial energetics / Dobutamine / Regional myocardium / PVA / 心室細動 / ePVA / eHR / e'PVA / エネルギー効率 / PVA (pressure-volume area) / VO2 (myocardial oxygen consumption) / ventricular fibrillation / ePVA (equivalent PVA) / eHR (equivalent heart rate) / 筋収縮 / 筋フィラメント / アクトミオシン / Muscle contraction / Myofilament / Actomyosin / Santan-clothing / 心筋内微小血管 / 力学的ストレス / 組織エナ-ジェティクス / 高分解能微小循環計測 / ニードル型生体顕微鏡 / 分子生体工学 / coronary circulation / intramyocardial microvessels / tissue energetics / high-resolution icrocirculatory measurement / needle-probe CCD intravital microscopy / molecula biomechanics / 血流調節 / 心内膜側 / メカニカルストレス / 心筋虚血 / 分子血流トレーサ / 血管反応 / 冠微少循環 / coronary microcirculation / blood flow regulation / myocardial ischemia / molecular flow tracer / vascular response / 虚血性心筋症 / Dor手術 / Batista手術 / 左心室瘤 / リモデリング / ACE阻害薬 / 心筋梗塞 / 酸化ストレス / Surgical treatment / Ischemic cardiomyopathy / Dor method / Batista method / 血流速度 / 貫壁性 / 筋節構造 / ミオシン格子 / X線回折 / 冠微小血管造影 / 心筋内灌流分布 / 分子トレーサー / アクチン・ミオシン / X線回折像解析 / 心筋線維配向 / マクロモレキュール / 冠微小血管 / 毛細血管可視化 / 3次元解析 / 容量血管 / 培養心筋細胞 / 拍動心臓 / 筋線維 / 心筋クロスブリッジ / 3D-microCT / Physiome / Coronary Circulation / Cardiac Contraction / Crossbridge Dynamics / Intravital CCD / Transmural characteristics / Vascular regUlation / 心筋症 / 拡張型心筋症 / 肝細胞増殖因子 / 心尖部温存左室形成術 / Cardiomyopathy / Dilated Cardiomyopathy / Hepatic Growth Factor / Surgical Treatment Less

Promotion of cardiovascular physiome focusing on coronary microcirculation and myocardial crossbridge dynamics
- Principal Investigator
  
  KAJIYA Fumihiko
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kawasaki University of Medical Welfare
  Kawasaki College of Allied Health Professions
拍動心内カルシウム及びクロスブリッジ動態のフィジオーム的解析方法論の開発と評価Principal Investigator
- Principal Investigator
  
  菅弘之
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  National Cardiovascular Center Research Institute
放射光を用いた心筋クロスブリッジ動態の実時間解析法の確立と臨床応用
- Principal Investigator
  
  白井幹康
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hiroshima International University
Research for effects of corroboration with apex sparing left ventricular repair surgery and hepatic growth factor using delivery sheet
- Principal Investigator
  
  NISHINA Takeshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  KYOTO UNIVERSITY
拍動心臓内カルシウム無駄サイクル及び収縮性カルシウム反応性の医用工学的推定法Principal Investigator
- Principal Investigator
  
  菅弘之
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  National Cardiovascular Center Research Institute
Research for Improving Effects of Clinical after Left Ventricle Repair Surgery on Chronic Cardiac Failure
- Principal Investigator
  
  KOMEDA Masashi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  KYOTO UNIVERSITY
Analysis of coronary microcirculation and myocardial crossbridge dynamic using SPring-8 synchrotron facility
- Principal Investigator
  
  KAJIYA Fumihiko
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Okayama University
高輝度放射光回折法による心筋アクチン・ミオシン相互作用の心周期内経時解析
- Principal Investigator
  
  TSUJIOKA Katsuhiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kawasaki Medical School
医学生物学の新しい機能原理:フィジオーム
- Principal Investigator
  
  KAJIYA Fumihiko
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kawasaki Medical School
統合生理学的分析法による心臓内カルシウム無駄サイクル数の推定法Principal Investigator
- Principal Investigator
  
  菅弘之
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Okayama University
Micromechanics Control of Coronary Circulation
- Principal Investigator
  
  KAJIYA Fumihiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kawasaki Medical School
Assessment of the total amount of CAィイD12+ィエD1 handled in the E-C coupling by analyzing postextrasystolic potentiation and OィイD22ィエD2 consumption : Systems approachPrincipal Investigator
- Principal Investigator
  
  SUGA Hiroyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Okayama University
Macro-micro correspondence in mechanoenagetics of failing heartsPrincipal Investigator
- Principal Investigator
  
  SUGA Hiroyuki
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Okayama University
イヌ摘出交叉潅流心を用いた麻酔薬の心力学及びエネルギー学的影響の解析
- Principal Investigator
  
  難波健利
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Okayama University
Interaction of coronary hemodynamical and biomolecular signals
- Principal Investigator
  
  KAJIYA Fumihiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kawasaki Medical School
The development of increasing the energetic efficiency of failing heart : Application of Emax and PVAPrincipal Investigator
- Principal Investigator
  
  SUGA Hiroyuki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Okayama University
心臓の能動素子としてのメカノエナジェティクスPrincipal Investigator
- Principal Investigator
  
  菅弘之
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okayama University
心臓の能動素子としてのバイオメカニクス的研究:心室振動法による容積弾性率とエネルギー消費量の変化Principal Investigator
- Principal Investigator
  
  菅弘之
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okayama University
Extensive studies on the dynamic aspects of myofilament sliding in muscle as a micromachine.
- Principal Investigator
  
  SUGI Haruo
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  広領域
- Research Institution
  School of Medicine, Teikyo University
心臓の能動素子としてのバイオメカニクス的研究:心室容積振動法による容積弾性等とエネルギー消費量の変化Principal Investigator
- Principal Investigator
  
  菅弘之
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okayama University
The relation between Ca^<2+>-transient and Ca^<2+>-handling energy in excitation-contraction couplingPrincipal Investigator
- Principal Investigator
  
  SUGA Hiroyuki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Okayama University Medical School
The development of evaluating method for oxygen wasting effects by cardiotonic agentsPrincipal Investigator
- Principal Investigator
  
  SUGA Hiroyuki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Okayama University
Mechanoenergetic analysis of ventricular fibrillation in isolated blood perfused dog hearts.
- Principal Investigator
  
  TOKIOKA Hiroaki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  麻酔学
- Research Institution
  Okayama University Medical School
Regional myocardial mechanics and energetics
- Principal Investigator
  
  GOTO Yoichi
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Methods to improve cardiac efficiency and load matching.Principal Investigator
- Principal Investigator
  
  SUGA Hiroyuki
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  National Cardiovascular Center Research Institute
Faclors ioncreasing the energy conversion efficiency of myocardial contractile machineryPrincipal Investigator
- Principal Investigator
  
  SUGA Hiroyuki
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  National Cardiovascular Cenler Research lnstitute,

All 2009 2007 2006 2005 2004 Other

All Journal Article Book

[Book] Sliding Filament Mechanism in Muscle Contraction : Fifty Years of Research.2005
- Author(s)
  Suga H(分担執筆)
- Total Pages
  431
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Mode of frequency distribution of external work efficiency of arrhythmic beats during atrial fibrillation remains normal in canine heart2009
- Author(s)
  Shimizu J, Mohri S, Ito H, Takaki M, Suga H.
- Journal Title
  
  J Physiol Sci. 59(1)
  
  Pages: 75-80
- NAID
  10025218261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17200033
[Journal Article] Effects of sustained length-dependent activation on in situ cross-bridge dynamics in rat hearts2007
- Author(s)
  Pearson JT, Shirai M, Tsuchimochi H, Schwenke DO, Ishida T, Kangawa K, Suga H, Yagi N
- Journal Title
  
  Biophys J. 93(12)
  
  Pages: 4319-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17200033
[Journal Article] Celsior preserved cardiac mechanoenergetics better than popular solutions in canine hearts2006
- Author(s)
  Oshima Y, Mohri S, Shimizu J, Iribe G, Imaoka T, Fujinaka W, Kiyooka T, Ishino K, Sano S, Kajiya F, Suga H
- Journal Title
  
  Ann Thorac Surg. 81(2)
  
  Pages: 658-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17200033
[Journal Article] Celsior preserved cardiac mechanoenergetics better than popular solutions in canine hearts.2006
- Author(s)
  Oshima Y, Suga H他9名
- Journal Title
  
  Ann Thorac Surg. 81
  
  Pages: 658-664
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Variable unstressed volume keeps normal distributions of canine left ventricular contractility and total mechanical energy under atrial fibrillation.2005
- Author(s)
  Mohri S, Suga H他5名
- Journal Title
  
  Jpn Physiol (印刷中)
- NAID
  10018623883
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Appraisal of crossbridge cycling in cardiac disease models by X-ray diffraction.2005
- Author(s)
  Pearson TJ, Suga H他5名
- Journal Title
  
  SPring-8 User Experiment Report 14
  
  Pages: 200-200
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Normal distribution of ventricular pressure-volume area of arrhythmic beats under atrial fibrillation in canine heart.2005
- Author(s)
  Mohri S, Suga H 他7名
- Journal Title
  
  Am J Physiol Heart Circ Physiol, 288
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Predictability of O2 consumption from contractility and mechanical energy of absolute arrhythmic beats in canine heart.2005
- Author(s)
  Shimizu J, Suga H他6名
- Journal Title
  
  Jpn J Physiol 55
  
  Pages: 135-142
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Invited Review : Assessment of systolic and diastolic ventricular properties via pressure-volume analysis : a guide for clinical, translational, basic researchers.2005
- Author(s)
  Burkhoff D, Suga H他1名
- Journal Title
  
  Am J Physiol Heart Circ Physiol 289
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Load independence of temperature-dependent Ca2+ recirculation fraction in canine heart.2004
- Author(s)
  Suga H. 他9名
- Journal Title
  
  Jpn J Physiol 54
  
  Pages: 319-329
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Mechanoenergetic estimation of multiple crossbridge steps per ATP in a beating heart.2004
- Author(s)
  Suga H
- Journal Title
  
  Jpn J Physiol 54
  
  Pages: 103-108
- NAID
  80016680300
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Alternans decay of postextrasystolic potentiation in human left ventricle.2004
- Author(s)
  Suga H. 他5名
- Journal Title
  
  Jpn J Physiol 54
  
  Pages: 87-91
- NAID
  80016562014
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Sarcomere-length dependence of lattice volume and radial mass transfer of myosin cross-bridges in rat papillary muscle.2004
- Author(s)
  Suga H. 他10名
- Journal Title
  
  Pfluegers Arch -Eur J physiol 448
  
  Pages: 153-160
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Normal distribution of ventricular pressure-volume area (PVA) of arrhythmic beats under atrial fibrillation in canine heart.
- Author(s)
  Suga H. 他8名
- Journal Title
  
  Am J Physiol Heart & Circ Physiol (In press)
- Data Source
  KAKENHI-PROJECT-16659057
[Journal Article] Starling-effect-independent lusitropism index in canine left ventricle : logistic time constan.
- Author(s)
  Mizuno J, Suga H 他9名
- Journal Title
  
  Anesthesia Analgesia (印刷中)
- Data Source
  KAKENHI-PROJECT-16659057

1. ARAKI Junichi (80271055)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. MOHRI Satoshi (00294413)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
3. KAJIYA Fumihiko (70029114)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
4. IRIBE Gentaro (90284885)

# of Collaborated Projects: 4 results

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5. MIKANE Takashi (10294406)

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6. TSUJIOKA Katsuhiko (30163801)

# of Collaborated Projects: 4 results

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7. YAGI Naoto (80133940)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
8. SHIMIZU Juichiro (80294403)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
9. GOTO Masami (50148699)

# of Collaborated Projects: 3 results

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10. OGASAWARA Yasuo (10152365)

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11. GOTO Yoichi (40142179)

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12. FUTAKI Shiho (60190112)

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13. TAKAKI Miyako (00033358)

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14. SUGIURA Seiryo (10272551)

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15. HIMENO Ryutaro (60342838)

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16. KAWAGUCHI Osamu (80214609)

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17. SUGAWARA Motoaki (60010914)

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18. KOMEDA Masashi (20303810)

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19. HIRAMATSU Osamu (50208849)

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20. TACHIBANA Hiroyuki (00241216)

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21. MOCHIZUKI Seiichi (60259596)

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22. KATAOKA Noriyuki (20250681)

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23. NAKAMURA Kazufumi (10335630)

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24. NINOMIYA Yoshifumi (70126241)

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25. KOBAYASHI Naoya (10325102)

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26. HATA Katsuya (20228464)

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27. TOKIOKA Hiroaki (90127572)

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28. HIRAKAWA Masahisa (70033058)

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SUGA Hiroyuki 菅 弘之

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拍動心内カルシウム及びクロスブリッジ動態のフィジオーム的解析方法論の開発と評価Principal Investigator

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拍動心臓内カルシウム無駄サイクル及び収縮性カルシウム反応性の医用工学的推定法Principal Investigator

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統合生理学的分析法による心臓内カルシウム無駄サイクル数の推定法Principal Investigator

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Assessment of the total amount of CAィイD12+ィエD1 handled in the E-C coupling by analyzing postextrasystolic potentiation and OィイD22ィエD2 consumption : Systems approachPrincipal Investigator

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Macro-micro correspondence in mechanoenagetics of failing heartsPrincipal Investigator

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SUGA Hiroyuki 菅弘之