HIROTA Kosaku 廣田耕作

… Alternative Names

廣田耕作ヒロタコウサク

広田耕作ヒロタコウサク

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Researcher Number	90082982
Other IDs
External Links
Affiliation (Current)	2025: 岐阜薬科大学, その他部局等, 名誉教授
Affiliation (based on the past Project Information) *help	2004 – 2005: 岐阜薬科大学, 薬学部, 教授 2001 – 2002: 岐阜薬科大学, 薬学部, 教授 1992 – 1993: 岐阜薬科大学, 薬学部, 助教授 1988 – 1989: 岐阜薬科大学, 薬学部, 助教授 1986: Gifu Pharm. Univ., Faculty of Pharmacy, Associate Prof., 薬学部, 助教授
Review Section/Research Field	Principal Investigator Drug development chemistry Except Principal Investigator Chemical pharmacy
Keywords	Principal Investigator fluorescence ligand / affinity ligand / TRL-7 / tool-like receptor / deazaadenine / 8-hydroxyadenine / interferon-inducing activity / インターフェロン誘導剤 / アデニン / 3-デアザアデニン … More / 1-デアザアデニン / インターフェロン誘導活性 / 蛍光リガンド / アフィニティリガンド / TLR-7 / トール様受容体 / デアザアデニン / 8-ヒドロキシアデニン / インターフェロン … More Except Principal Investigator PCB / 複素環N-オキシド / DNA鎖切断反応 / 水酸ラジカル / 光酸化反応 / Functional molecule / Photo-induced single-electron transfer / Chemical model / Pyrimidopteridine N-oxide / Dehydrogenation / Oxygenation / Photooxidation / Heterocyclic N-oxide / 生体内代謝の化学モデル / 光化学反応機構 / 光化学的酸素原子添加反応 / 含窒素複素環Nーオキシド・ピリミド[54ーg]プテリジンーNーオキシド / 機能的分子 / 光誘起電子移動 / 生体反応モデル / ピリミドプテリジンN-オキシド / 機能性分子 / 光励起電子移動 / 化学モデル / ピリミドプテリジンNーオキシド / 脱水素反応 / 酸素原子添加反応 / 光化学的酸化 / 複素環Nーオキシド / antibacterial activity / regio-selective chemical modification / transition-state analogs / <beta> -lactam antibiotics / β-ラクタマーゼ阻害作用 / 抗菌作用 / 位置選択的な化学修飾 / 遷移状態類似体 / β-ラクタム系抗生物質 / Degradation / Aroclor / Aromatic Chlorides / Triethylamine / Palladium on Carbon / Hydrogenation / Dechlorination / 無毒化 / アロクロール / 芳香族塩素化合物 / トリエチルアミン / パラジウム炭素 / 接触還元 / 脱塩素化 / 蛋白質障害 / 核酸障害 / プリンヌクレオシド / 一電子移動反応 / 機能性複素環N-オキシド Less

Synthesis of adenine derivatives possessing interferon inducing activity and creation of receptor ligand with high affinityPrincipal Investigator
- Principal Investigator
  
  HIROTA Kosaku
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu Pharmaceutical University
Complete Degradation Method of PCBs Using Catalytic Dechlorination Reaction
- Principal Investigator
  
  SAJIKI Hironao
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Gifu Pharmaceutical University
複素環N-オキシドを用いる高効率水酸ラジカル発生法の開発とその応用
- Principal Investigator
  
  牧敬文
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Gifu Pharmaceutical University
機能性複素環N-オキシドによる生体物質及び外来物質の光酸化反応
- Principal Investigator
  
  MAKI Yoshifumi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Gifu Pharmaceutical University
Construction of Heterocyclic N-oxides possessing Highly Photooxidative Capacity and its Application
- Principal Investigator
  
  MAKI Yoshifumi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Gifu Pharmaceutical University
Synthesis of Transition-state Analogs of Penicillin and their Biological Activity
- Principal Investigator
  
  MAKI Yoshifumi
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Gifu Pharmaceutical University

All 2005 2004

All Journal Article

[Journal Article] Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities2005
- Author(s)
  A.Kurimoto, T.Ogino, S.Ichii, H.Y.Isobe, M.Tobe, H.Ogita, H.Takaku, H.Sajiki, K.Hirota, H.Kawakami
- Journal Title
  
  Bioorganic & Medicinal Chemistry 12
  
  Pages: 1091-1099
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590087
[Journal Article] Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities2004
- Author(s)
  A.Kurimoto, T.Ogino, S.Ichii, H.Y.Isobe, M.Tobe, H.Ogita, H.Takaku, H.Sajiki, K.Hirota, H.Kawakami
- Journal Title
  
  Bioorganic & Medicinal Chemistry 12・5
  
  Pages: 1091-1099
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590087
[Journal Article] Synthesis and structure-activity relationship of adenine derivatives with interferon-inducing activity2004
- Author(s)
  K.Kazaoka, H.Sajiki, K.Hirota
- Journal Title
  
  Gifu Yakka Daigaku Kayo 53
  
  Pages: 1-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590087
[Journal Article] インターフェロン誘導活性を有するアデニン誘導他の合成と構造活性相関に関する研究2004
- Author(s)
  風岡和憲, 佐治木弘尚, 廣田耕作
- Journal Title
  
  岐阜薬科大学紀要 53
  
  Pages: 1-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590087
[Journal Article] Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities2004
- Author(s)
  A.Kurimoto, T.Ogino, S.Ichii, H.Sajiki, K.Hirota, H.Kawakami
- Journal Title
  
  Bioorganic & Medicinal Chemistry 12・5
  
  Pages: 1091-1099
- Data Source
  KAKENHI-PROJECT-16590087

1. MAKI Yoshifumi (00082959)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. KITADE Yukio (20137061)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. SAKO Magoichi (10137060)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. SAJIKI Hironao (50275096)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. MAEGAWA Tomohiro (40363890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIROTA Kosaku 廣田 耕作

廣田 耕作 ヒロタ コウサク

広田 耕作 ヒロタ コウサク

Research Projects

Research Products

Co-Researchers

Synthesis of adenine derivatives possessing interferon inducing activity and creation of receptor ligand with high affinityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Complete Degradation Method of PCBs Using Catalytic Dechlorination Reaction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

複素環N-オキシドを用いる高効率水酸ラジカル発生法の開発とその応用

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

機能性複素環N-オキシドによる生体物質及び外来物質の光酸化反応

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Construction of Heterocyclic N-oxides possessing Highly Photooxidative Capacity and its Application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis of Transition-state Analogs of Penicillin and their Biological Activity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Synthesis and structure-activity relationship of adenine derivatives with interferon-inducing activity2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] インターフェロン誘導活性を有するアデニン誘導他の合成と構造活性相関に関する研究2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities2004

Author(s)

Journal Title

Data Source

HIROTA Kosaku 廣田耕作

廣田耕作ヒロタコウサク

広田耕作ヒロタコウサク