HIRAYAMA Fumitoshi 平山文俊

… Alternative Names

HIRAYAMA Fumitoshi Ph. D 平山文俊

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Researcher Number	90094036
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2006 – 2016: 崇城大学, 薬学部, 教授 2003 – 2005: Kumamoto University, Graduate School of Medical and Pharmaceutical Sciences, Professor, 大学院・医学薬学研究部, 助教授 1997 – 2002: 熊本大学, 薬学部, 助教授 1990 – 1991: 熊本大学, 薬学部, 助教授
Review Section/Research Field	Principal Investigator Physical pharmacy / Physical pharmacy Except Principal Investigator 応用薬理学・医療系薬学 / Medical pharmacy / Physical pharmacy
Keywords	Principal Investigator 結晶多形 / シクロデキストリン / 包接複合体 / 結晶化 / 溶液媒介性多形転移 / 晶癖 / Crystal engineering / Crystal growth / Crystallization / Polymorphism … More / Amorphous complex / Chlorpropamide / Tolbutamide / Cyclodextrin / 結晶工学 / 結晶成長 / 非晶質性複合体 / クロルプロパミド / トルブタミド / 多形転移 / ゲル / モルホロジー / 安定化 / 非晶質複合体 / プロスタグランジン / 米国 / 結晶成長速度 / 新規結晶多形 / アスピリン / アセトヘキサミド / 溶出挙動 / 溶解速度 / 準安定結晶 … More Except Principal Investigator シクロデキストリン / siRNA / 結合体 / デンドリマー / Cyclodextrin / carrier / デリバリー / キャリア / conjugate / dendrimer / cyclodextrin / 腸内細菌叢 / 生体内分解性 / プロドラッグ / 大腸特異的薬物送達 / protein drugs / Peptide / 標的指向化 / 放出制御 / cell specific delivery / Dendrimer / 糖修飾体 / シクロテキストリン / 細胞選択的 / multifunctionalization / delivery / Lipofectamine 2000 / RNAi効果 / 高機能化 / cytotoxicity / gene transfer / 核移行シグナル / マンノース / ガラクトース / 遺伝子キャリアー / 細胞障害性 / 遺伝子導入 / Targeting / Release-control / Absorption enhancement / Inhibition of aggregation / Bioadaptability / Functional drug carrier / Cyclodextrins / 薬物放出制御 / 粘膜付着性 / 環状オリゴ糖 / 可溶化剤 / 安定化剤 / 熱変性 / 分岐型環状オリゴ糖 / 吸収促進 / 凝集抑制 / 生体適合性 / ペプチド・蛋白性薬物 / 機能性薬物担体 / 環状オリゴ糖誘導体 / Alleviation of side effect / Inflammatory bowel disease rats / Prednisolone / Colonic microflora / Ester-type prodrug / Biodegradable drug carrier / Colon specific delivery / n-酪酸 / 副作用軽減 / IBDモデルラット / プレドニゾロン / Antiinflammatory Effect / Biphenylyl Acetic Acid / Intestinal Microflora / Biodegradation / Prodrug / Colon-specific Drug Delivery / 消炎鎮痛薬 / 抗炎症作用 / ビフェニル酢酸 / Lipophilic absorption enhancer / Cyclodextrin derivatives / Insulin aggregation / Proteolytic degradation / Hypoglycemia / Enhanced nasal absorption / Insulin / 酢酸ブセレリン / メチル化シクロデキストリン / 鼻粘膜適用製剤 / 脂溶性吸収促進剤 / シクロデキストリン誘導体 / インスリン凝集 / 蛋白分解 / 血糖降下作用 / 鼻粘膜吸収改善 / インスリン / 生理活性ペプチド / 製剤設計 / バイオアベイラビリティ改善 / ナノ粒子形成 / 抗酸化物質 / ナノ粒子化 / スーパージェネリック製剤 / 結晶形態の制御 / Polypseudorotaxane / PEG化インスリン / ナノ粒子 / フラーレンC60 / 包接複合体 / 親水性シクロデキストリン Less

Control of Crystal Polymorph Transition and Morphology Utilizing Cyclodextrin ComplexationPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Fumitoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Sojo University
Controls of Solution-mediated Polymorphic Transition and Crystal Growth Rate Utilizing Cyclodextrin ComplexationPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Fumitoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Sojo University
Selective Preparation of Metastable Polymorphs Utilizing Inclusion Complexation with CyclodextrinsPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Fumitoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Sojo University
Potential Use of Cyclodextrins in the Development of Patient-Friendly Super-Generic Preparations
- Principal Investigator
  
  UEKAMA Kaneto
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Sojo University
High functionalization of dendrimer/cyclodextrin conjugate as a novel siRNA carrier
- Principal Investigator
  
  ARIMA Hidetoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kumamoto University
Design and Evaluation of dendrimer/cyclodextrin conjugates as a novel siRNA carrier
- Principal Investigator
  
  ARIMA Hidetoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kumamoto University
Design and Evaluation of Dendrimer/Cyclodextrin Conjugate as a Novel Gene Carrier
- Principal Investigator
  
  ARIMA Hidetoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kumamoto University
Development of High-performance Cyclic-oligosaccharide-Based Peptide/protein Delivery System Having Biodegradable Characteristics
- Principal Investigator
  
  UEKAMA Kaneto
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Control of Crystallization and Crystal Growth of Drug by Cyclodextrin ComplexationPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Fumitoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Design and Evaluation of Cyclic-oligosaccharide-Based Colon Specific Delivery System Having Biodegradable Characteristics
- Principal Investigator
  
  UEKAMA Kaneto
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kumamoto University
Colon-Specific Drug Delivery System Based on Cyclodextrin Conjugate
- Principal Investigator
  
  UEKAMA Kaneto
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kumamoto University
Improvement of Stability and Nasal Absorption of Peptide/Protein Drugs by Cyclodextrin Derivatives
- Principal Investigator
  
  UEKAMA Kaneto Ph. D.
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kumamoto University

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Other

[Book] 各種薬物の製剤特性改善におけるシクロデキストリンの有用性 in “シクロデキストリンの科学と技術”2013
- Author(s)
  上釜兼人、平山文俊、安楽誠、庵原大輔
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-23590063
[Book] 各種薬物の製剤特性改善におけるシクロデキストリンの有用性.in"シクロデキストリンの科学と技術"2013
- Author(s)
  上釜兼人、平山文俊、安楽誠、庵原大輔
- Total Pages
  314
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-23590063
[Book] The Practice of Medicinal Chemistry (3^<rd> version)(Improvement of Drug Properties by Cyclodextrins)2008
- Author(s)
  K.Uekama, F.Hirayama
- Publisher
  Academic Press Limited, London
- Data Source
  KAKENHI-PROJECT-20590050
[Book] The Practice of Medicinal Chemistry2008
- Author(s)
  K. Uekama and F. Hirayama
- Publisher
  C.G. Wermuth, AcademicPress
- Data Source
  KAKENHI-PROJECT-19590169
[Book] Improvement of Drug Properties by Cyclodextrills., in "The Practice of Medicinal Chemistry (3rd Edition)"2008
- Author(s)
  K. Uekama, F. Hirayama
- Total Pages
  23
- Publisher
  Academic Press, London
- Data Source
  KAKENHI-PROJECT-19590169
[Book] Biotechnology: Pharmaceutical Aspect2007
- Author(s)
  F. Hirayama and K. Uekama
- Publisher
  AAPS Press
- Data Source
  KAKENHI-PROJECT-19590169
[Book] Prodrugs:Vhallenges and Rewards(Part 1)2007
- Author(s)
  F.Hirayama and K.Uekama
- Total Pages
  734
- Publisher
  AAPS Press,New York
- Data Source
  KAKENHI-PROJECT-19590169
[Journal Article] Ternary Inclusion Complex Formation and Stabilization of Limaprost, a Prostaglandin E1 Derivative, in the Presence of α- and β-Cyclodextrins in the Solid State2016
- Author(s)
  Y. Inoue, D. Iohara, N. Sekiya, M. Yamamoto, H. Ishida, Y. Sakiyama, F. Hirayama, H. Arima and K. Uekama
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 509 Issue: 1-2 Pages: 338-347
- DOI
  10.1016/j.ijpharm.2016.06.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460054, KAKENHI-PROJECT-15K07913
[Journal Article] Formation of the Ternary Inclusion Complex of Limaprost with α- and β-Cyclodextrins in Aqueous Solution2015
- Author(s)
  Y. Inoue, N. Sekiya, M. Yamamoto, D. Iohara, F. Hirayama, K. Uekama
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 63 Issue: 5 Pages: 318-325
- DOI
  10.1248/cpb.c14-00733
- NAID
  130005067244
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460054, KAKENHI-PROJECT-15K07913
[Journal Article] Formation of the ternary inclusion complex of limaprost with a- and b-cyclodextrins in aqueous solution2015
- Author(s)
  Y. Inoue, N. Sekiya, M. Yamamoto, D. Iohara, F. Hirayama, K. Uekama
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 63 Pages: 318-325
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460054
[Journal Article] Stabilizing Effect of β-Cyclodextrin on Limaprost, a PGE1 Derivative, in Limaprost Alfadex Tablets (Opalmon) in Highly Humid Conditions2014
- Author(s)
  Y. Inoue, N. Sekiya, K. Katayama, S. Narutaki, M. Yamamoto, D. Iohara, F. Hirayama, K. Uekama
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 62 Pages: 786-792
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460054
[Journal Article] Antioxidant and Renoprotective Activity of Chitosan in Nephrectomizded Rat2013
- Author(s)
  A. Hiraga, M. Anraku, D. Iohara, K. Uekama, M.Otagiri, F. Hirayama
- Journal Title
  
  Chtin and Chitosan Research
  
  Volume: 19 Pages: 24-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590063
[Journal Article] Preparation of Soluble Stable C60/Human Serum Albumin Nanoparticles via Cyclodextrin Complexation and Their Reactive Oxygen Production Characteristics2013
- Author(s)
  A. Altaf, H. Aldawsari, Z.M. Banjar, M. Anraku, D. Iohara, M. Otagiri, K. Uekama, F. Hirayama
- Journal Title
  
  Life Sci
  
  Volume: 93 Issue: 7 Pages: 277-282
- DOI
  10.1016/j.lfs.2013.06.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590063, KAKENHI-PROJECT-23790211, KAKENHI-PROJECT-25860034
[Journal Article] Crystallization of A New Polymorph of Acetohexamide from 2-Hydroxybutyl-b-cyclodextrin Solution: Form VI with High Aqueous Solubility2013
- Author(s)
  H. Aldawsari, A. Altaf, Z.M. Banjar, D. Iohara, M. Nakabayashi, M. Anraku, K. Uekama, F. Hirayama
- Journal Title
  
  Int. J. Pham.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590063
[Journal Article] Preparation of Soluble Stable C60/Human Serum Albumin Nanoparticles via Cyclodextrin Complexation and Their Reactive Oxygen Production Characteristics2013
- Author(s)
  A. Altaf, H. Aldawsari, Z.M. Banjar, M. Anraku, D. Iohara, M. Otagiri, K. Uekama and F. Hirayama
- Journal Title
  
  Life Sci.
  
  Volume: 93 Pages: 277-282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590063
[Journal Article] Crystallization of A New Polymorph of Acetohexamide from 2-Hydroxybutyl-b- cyclodextrin Solution: Form VI with High Aqueous Solubility2013
- Author(s)
  H. Aldawsari, A. Altaf, Z.M. Banjar, D. Iohara, M. Nakabayashi, M. Anraku, K. Uekama and F. Hirayama
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 453 Issue: 2 Pages: 315-321
- DOI
  10.1016/j.ijpharm.2013.06.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590063, KAKENHI-PROJECT-23790211
[Journal Article] Cyclodextrin-induced Change in Crystal Habit of Acetylsalicylic Acid in Aqueous Solution2012
- Author(s)
  D. Iohara, K. Yoshida, K. Yamaguchi, M. Anraku, K. Motoyama, H. Arima, K. Uekama and F. Hirayama
- Journal Title
  
  Crystal Growth & Design
  
  Volume: 12 Pages: 1985-1991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590063
[Journal Article] Evaluation of photodynamic activity ofC/2-hydroxypropyl-β-cyclodextrinNanoparticles.2012
- Author(s)
  Daisuke Iohara, Masaaki Hiratsuka,Fumitoshi Hirayama, Keizo Takeshita, KeiichiMotoyama, Hidetoshi Arima, Kaneto Uekama;
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 101(9) Issue: 9 Pages: 3390-3397
- DOI
  10.1002/jps.23045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590052, KAKENHI-PROJECT-22590164, KAKENHI-PROJECT-23590063, KAKENHI-PROJECT-23790062
[Journal Article] Antioxidant and Renoprotec- tive Activity of Chitosan in Nephrecto- mized Rats2012
- Author(s)
  M. Anraku, H. Tomida, A. Michihara, A. Tsuchiya, D. Iohara, Y. Maezaki, K. Uekama, T. Maruyama, M. Otagiri, F. 2 Hirayama
- Journal Title
  
  Carbohydr. Polymers
  
  Volume: 89 Issue: 1 Pages: 302-304
- DOI
  10.1016/j.carbpol.2012.03.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590063, KAKENHI-PROJECT-23790211
[Journal Article] Cyclodextrin-induced change in crystal habit of acetylsalicylic acid in aqueous solution2012
- Author(s)
  D. Iohara, K. Yoshida, K. Yamaguchi, M. Anraku, K. Motoyama, H. Arima, K. Uekama, F.Hirayama
- Journal Title
  
  Cryst. Growth Des.
  
  Volume: 12 Issue: 4 Pages: 1985-1991
- DOI
  10.1021/cg201691c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590164, KAKENHI-PROJECT-23590063, KAKENHI-PROJECT-23790211
[Journal Article] Effect of Sulfobutyl ether-β-cyclodextrin on Bio- availability of Insulin Glargine and Blood Glucose Level after Subcuta- neous Injection to Rats2011
- Author(s)
  K. Uehata, T. Anno, K. Hayashida, K. Motoyama, F. Hirayama, N. Ono, J.D. Pipkin, K. Uekama, H. Arima
- Journal Title
  
  Int. J. Pharm
  
  Volume: 419 Issue: 1-2 Pages: 71-76
- DOI
  10.1016/j.ijpharm.2011.07.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590063
[Journal Article] Some pharmaceutical and inclusion properties of 2-hydroxybutyl-β-cyclodextrin derivative2011
- Author(s)
  T. Ishiguro, E. Morishita, D. Iohara, F. Hirayama, K. Wada, H. Arima, K. Motoyama,K. Uekama
- Journal Title
  
  J. Pharm.
  
  Volume: 419 Issue: 1-2 Pages: 161-169
- DOI
  10.1016/j.ijpharm.2011.07.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590164, KAKENHI-PROJECT-23590063
[Journal Article] Formation of Stable Hydrophilic C_<60> Nanoparticles by Hdroxypropyl-β-cyclodextrin2011
- Author(s)
  D.Iohara, F.Hirayama, K.Higashi, K.Yamamoto, K.Uekama
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 8 Issue: 4 Pages: 1276-1284
- DOI
  10.1021/mp200204v
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590164, KAKENHI-PROJECT-23590063, KAKENHI-PROJECT-23790062
[Journal Article] Reduction of bitterness of antihistaminic drugs by com-plexation with β-cyclodextrin2011
- Author(s)
  N. Ono, Y. Miyamoto, T. Ishiguro, K.Motoyama, F. Hirayama, D. Iohara, H. Seo, S.Tsuruta, H. Arima, K. Uekama
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 100 Issue: 5 Pages: 1935-1943
- DOI
  10.1002/jps.22417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590164, KAKENHI-PROJECT-23590063
[Journal Article] Improvement of Some Physicochemical Properties of Arundic Acid, (R)-(-)-2-Propyloctanonic Acid, by Complexation with Hydrophilic Cyclodextrins2011
- Author(s)
  Y.Miyamoto, M.Nakahara, K.Motoyama, T.Ishiguro, Y.Oda, T.Yamanoi, I.Okamoto, A.Yagi, H.Nishimura, F.Hirayama, K.Uekama, H.Arima
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 413 Issue: 1-2 Pages: 63-71
- DOI
  10.1016/j.ijpharm.2011.04.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590164, KAKENHI-PROJECT-23590063
[Journal Article] Crystallization and Polymorphic Transition of Chlorpropamide in Aqueous 2-Hydroxybutyl-β-cyclodextrin Solution2010
- Author(s)
  T.Ishiguro, F.Hirayama, D.Iohara, H.Arima, K.Uekama
- Journal Title
  
  Eur.J.Pharm.Sci.
  
  Volume: 39 Pages: 248-255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590050
[Journal Article] Crystallization and Polymorphic Transition of Chlorpropamide in Aqueous 2-Hydroxybutyl-β-cyclodextrin Solu-tion2010
- Author(s)
  T.Ishiguro, F.Hirayama, D.Iohara, H.Arima, K.Uekama
- Journal Title
  
  Eur.J.Pharm.Sci. 39
  
  Pages: 248-255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590050
[Journal Article] Crystallization and Polymorphic Transition of Chlorpropamide in Aqueous 2-Hydroxybutyl-β-cyclodextrin Solution2010
- Author(s)
  T.Ishiguro, F.Hirayama, D.Iohara, H.Arima, K.Uekama
- Journal Title
  
  Eur.J.Pharm.Sci. 39
  
  Pages: 248-255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590050
[Journal Article] シクロデキストリンを用いた製剤からの薬物の溶出性、吸収性の改善2009
- Author(s)
  上釜兼人、平山文俊、庵原大輔
- Journal Title
  
  ファルマシア 45
  
  Pages: 1223-1227
- Data Source
  KAKENHI-PROJECT-20590050
[Journal Article] Slow Release System of Randomly-Pegylated Insulin by Polypseudorotaxane Formation with Cyclodextrins2009
- Author(s)
  T. Higashi, F. Hirayama, S. Misumi, K. Motoyama, H. Arima, K. Uekama
- Journal Title
  
  Chem. Pharm. Bull 56
  
  Pages: 541-544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590169
[Journal Article] シクロデキストリンを用いた製剤からの薬物の溶出性、吸収性の改善2009
- Author(s)
  上釜兼人、平山文俊、庵原大輔
- Journal Title
  
  ファルマシア(総説) 45
  
  Pages: 1223-1227
- Data Source
  KAKENHI-PROJECT-20590050
[Journal Article] Preparation of Amorphous Indomethacin from Aqueous 2,6-Di-O-methyl-β-cyclodextrin Solution2008
- Author(s)
  D.Iohara, F.Hirayama, T.Ishiguro, H.Arima, K.Uekama
- Journal Title
  
  Int.J.Pharm. 354
  
  Pages: 70-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590050
[Journal Article] Preparation of Amorphous Indomethacin from Aqueous 6-Di-O-methyl-β-cyclodextrin Solution2008
- Author(s)
  D. Iohara, F. Hirayama, T. Ishiguro, H. Arima, K., Uekama
- Journal Title
  
  Int.J.Pharmaceut 354
  
  Pages: 70-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590169
[Journal Article] Preparation of Amorphous Indomethacin from Aqueous 2,6-di-O-methyl-β-cyclodextrin Solution2008
- Author(s)
  D.Iohara, F.Hirayama, T.Ishiguro, H.Arima, K.Uekama
- Journal Title
  
  Int.J.Pharm. 354
  
  Pages: 70-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590169
[Journal Article] Pseudorotaxane-like Supramolecular Complex of Coenzyme Q_<10> with γ-Cyclodextrin Formed by Solubility Method2008
- Author(s)
  K.Nishimura, T.Higashi, A.Yoshimatsu, F.Hirayama, K.Uekama, H.Arima
- Journal Title
  
  Chem.Pharm.Bull 56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590169
[Journal Article] Improved Stability of OPALMONR Tablets under HumidConditions IV :Formulation Development Study2008
- Author(s)
  N. Sekiya, A. Nishiwaki, A. Nishiura, M. Yamamoto, K. Takeda, D. Iohara, F. Hirayama, H. Arima, K. Uekama
- Journal Title
  
  Chem. Pharm. Bull 56
  
  Pages: 7-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590169
[Journal Article] Improved Stability of OPALMON[○!R] Tablets under Humid Conditions IV:Formulation Development Study2008
- Author(s)
  N.Sekiya, A.Nishiwaki, A.Nishiura, M.Yamamoto, K.Takeda, D.Iohara, F.Hirayama, H.Anima, K.Uekama
- Journal Title
  
  Chem, Pharm. Bull 56
  
  Pages: 7-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590169
[Journal Article] Design and Evaluation of Polypseudorotaxanes of Pegylated Insulin with Cyclodextrins as Sustained Release System2008
- Author(s)
  T. Higashi, F. Hirayama, S. Misumi, H. Arima, K. Uekama
- Journal Title
  
  Biomaterials 29
  
  Pages: 3866-3871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590169
[Journal Article] Prominent Inhibitory Effect of 2-Hydroxybutyl-β-cyclodextrin on Solution-mediated Polymorphic Transition of Chlorpropamide2008
- Author(s)
  T. Ishiguro, F. Hirayama, D. Iohara, K. Uekama
- Journal Title
  
  Chem. Lett 37
  
  Pages: 816-817
- NAID
  10024281162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590169
[Journal Article] Design and Evaluation of Polypseudorotaxanes of Pegylated Insulin with Cyclodextrins as Sustained Releas System.2008
- Author(s)
  T. Higashi, F. Hirayama, S. Misumi, H. Arima, K. Uekama
- Journal Title
  
  Biomaterials 29
  
  Pages: 3866-3871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590169
[Journal Article] Prominent Inhibitory Effect of 2-Hydroxybutyl-β-cyclodextrins on Solution Mediated Polymorphic Transition of Chlorpropamide2008
- Author(s)
  T.Ishiguro, F.Hirayama, D.Iohara, K.Uekama
- Journal Title
  
  Chem.Lett. 37
  
  Pages: 816-817
- NAID
  10024281162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590050
[Journal Article] Pseudorotaxane-like Supramolecular Complex of Coenzyme Q10 with γ-Cyclodextrin Formed by Solubility Method2008
- Author(s)
  K. Nishimura, T. Higashi, A. Yoshimatsu, F. Hirayama, K. Uekama, H. Arima
- Journal Title
  
  Chem. Pharm. Bull 56
  
  Pages: 701-706
- NAID
  110006663996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590169
[Journal Article] Pseudorotaxane-like Supramolecular Complex of Coenzyme Q10 with γ-Cyclodextrin Formed by Solubility Method2008
- Author(s)
  K. Nishimura, T. Higashi, A. Yoshimatsu, F. Hirayama, K. Uekama, H. Arima
- Journal Title
  
  Chem. Pharm. Bull. 56
  
  Pages: 7-11
- NAID
  110006663996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590169
[Journal Article] Prominent Inhibitory Effect of 2-Hydroxybutyl-β-cyclodextrin on Solution-mediated Polymorphic Transition of Chlorpropamide2008
- Author(s)
  T. Ishiguro, F. Hirayama, D. Iohara, K. Uekama
- Journal Title
  
  Chem. Lett. 37
  
  Pages: 816-817
- NAID
  10024281162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590169
[Journal Article] Serum-resistant Gene Transfer Activity of Mannosylated Dendrimer/α-Cyclodextrin Conjugate (G3)2006
- Author(s)
  Y.Chihara, H.Arima, M.Arizona, K.Wada, F.Hirayama, K.Uekama
- Journal Title
  
  J.Incl.Phenom.Macrocycl.Chem. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590114
[Journal Article] Potential Use of Dendrimer/α-Cyclodextrin Conjugate as a Novel Carrier for Small Interfering RNA (siRNA)2006
- Author(s)
  T.Tsutsumi, H.Arima, F.Hirayama, K.Uekama
- Journal Title
  
  J.Incl.Phenom.Macrocycl.Chem. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590114
[Journal Article] Improvement of gene delivery mediated by mannosylated dendrimer/α-cyclodextrin conjugates.2005
- Author(s)
  K.Wada, H.Arima, T.Tsutsumi, Y.Chihara, K.Hattori, F.Hirayama, K.Uekama
- Journal Title
  
  J.Control.Release 104-2
  
  Pages: 397-414
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590114
[Journal Article] Enhancing Effects of Galactosylated Dendrimer/α-Cyclodextrin Conjugates on Gene Transfer Efficiency.2005
- Author(s)
  K.Wada, H.Arima, T.Tsutsumi, F.Hirayama, K.Uekama
- Journal Title
  
  Biol.Pharm.Bull. 28-3
  
  Pages: 500-505
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590114
[Presentation] リマプロスト/α-/β-シクロデキストリン３成分包接複合体の形成と固体状態でのリマプロスト安定化機構の解明2016
- Author(s)
  庵原大輔、井上靖雄、関屋昇、山本政信、石田宏之、崎山庸子、安楽誠、有馬英俊、上釜兼人、平山文俊
- Organizer
  第３３回シクロデキストリンシンポジウム
- Place of Presentation
  かがわ国際会議場（香川県高松市）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-26460054
[Presentation] 親水性シクロデキストリン/水酸化フラーレンナノ粒子の調製と抗酸化能評価2013
- Author(s)
  梅崎至高、庵原大輔、安楽誠、上釜兼人、平山文俊
- Organizer
  第３０回シクロデキストリンシンポジウム
- Place of Presentation
  くまもと県民交流館パレア（熊本県熊本市）
- Data Source
  KAKENHI-PROJECT-23590063
[Presentation] 慢性腎不全モデルラットにおける2-ヒドロキシプロピル-b-シクロデキストリンの抗酸化および腎保護効果の検討2013
- Author(s)
  石田裕太郎、梅崎至高、和田幸樹、庵原大輔、安楽誠、小田切優樹、上釜兼人、平山文俊
- Organizer
  第３０回シクロデキストリンシンポジウム
- Place of Presentation
  くまもと県民交流館パレア（熊本県熊本市）
- Data Source
  KAKENHI-PROJECT-23590063
[Presentation] Cyclodextrin/Sangelose系の解離平衡に基づく温度感受性sol-gel変換システムの徐放性点眼剤への応用2013
- Author(s)
  大久保尚徳、庵原大輔、安楽誠、平山文俊、上釜兼人
- Organizer
  第３０回シクロデキストリンシンポジウム
- Place of Presentation
  くまもと県民交流館パレア（熊本県熊本市）
- Data Source
  KAKENHI-PROJECT-23590063
[Presentation] シクロデキストリンによる薬物の結晶化および晶癖の制御2011
- Author(s)
  平山文俊
- Organizer
  第36回製剤セミナー
- Place of Presentation
  ヤマハリゾートつま恋、静岡
- Invited
- Data Source
  KAKENHI-PROJECT-23590063
[Presentation] シクロデキストリンによる薬物の結晶多形転移の制御2011
- Author(s)
  平山文俊
- Organizer
  日本薬剤学会第２６年会(招待講演)
- Place of Presentation
  タワーホール船橋（東京）
- Data Source
  KAKENHI-PROJECT-23590063
[Presentation] シクロデキストリンによる薬物の結晶多形転移の制御2011
- Author(s)
  平山文俊
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船橋、埼玉
- Invited
- Data Source
  KAKENHI-PROJECT-23590063
[Presentation] シクロデキストリンによる薬物の結晶化および晶癖の制御2011
- Author(s)
  平山文俊
- Organizer
  第３６回製剤セミナー(招待講演)
- Place of Presentation
  ヤマハリゾートつま恋（静岡）
- Data Source
  KAKENHI-PROJECT-23590063
[Presentation] アセトヘキサミドの結晶化に及ぼす2-ヒドロキシブチル-β-シクロデキストリンの影響2011
- Author(s)
  中林磨実、庵原大輔、平山文俊、上釜兼人、安楽誠
- Organizer
  第28回シクロデキストリンジンポジウム
- Place of Presentation
  秋田ビューホテル、秋田
- Data Source
  KAKENHI-PROJECT-23590063
[Presentation] 2-ヒドロキシブチル-β-シクロデキストリンを用いたアセトヘキサミド新規結晶多形の調製2011
- Author(s)
  中林磨実、庵原大輔、安楽誠、上釜兼人、平山文俊
- Organizer
  第28回日本薬学会九州支部大会
- Place of Presentation
  福岡大学薬学部、福岡
- Data Source
  KAKENHI-PROJECT-23590063
[Presentation] Pharmaceutical Evaluation of 2-Hydroxybutyl-β-cyclodextrin as Drug Carrier : Dissolution Studies Using Flow through Cell Apparatus2010
- Author(s)
  森下絵理、庵原大輔、石黒貴子、和田幸樹、平山文俊、本山敬一、有馬英俊、上釜兼人
- Organizer
  The 15th International Cyclodextrin Symposium
- Place of Presentation
  ウィーン、オーストリア
- Year and Date
  2010-05-09
- Data Source
  KAKENHI-PROJECT-20590050
[Presentation] 2-ヒドロキシブチル-β-シクロデキストリンの物性と包接能の評価研究2010
- Author(s)
  森下絵理、庵原大輔、石黒貴子、和田幸樹、平山文俊、本山敬一、有馬英俊、上釜兼人
- Organizer
  第27回シクロデキストリンシンポジウム
- Place of Presentation
  金沢
- Year and Date
  2010-09-06
- Data Source
  KAKENHI-PROJECT-20590050
[Presentation] 新規シクロデキストリン誘導体2-ヒドロキシブチル-β-シクロデキストリンの製剤素材としての有用性評価2010
- Author(s)
  森下絵理、庵原大輔、石黒貴子、和田幸樹、平山文俊、本山敬一、有馬英俊、上釜兼人
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-20590050
[Presentation] シクロデキストリン誘導体存在下におけるアスピリンの結晶成長2009
- Author(s)
  平山文俊、庵原大輔、上釜兼人
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡
- Year and Date
  2009-05-23
- Data Source
  KAKENHI-PROJECT-20590050
[Presentation] シクロデキストリンを利用した固形薬物の結晶多形転移および晶癖の制御2009
- Author(s)
  平山文俊,庵原大輔,上釜兼人
- Organizer
  第2回シクロデキストリンワークショップ
- Place of Presentation
  熊本
- Year and Date
  2009-11-01
- Data Source
  KAKENHI-PROJECT-20590050
[Presentation] シクロデキストリン誘導体を用いたアスピリンの面選択的な結晶成長制御2009
- Author(s)
  吉田賢史, 平山文俊, 庵原大輔, 山口幸樹, 吉武康之, 原野一誠, 本山敬一有馬英俊, 上釜兼人
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590169
[Presentation] 2-ヒドロキシブチル-β-シクロデキストリンを利用したクロルプロパミドの準安定形結晶の選択的調製2009
- Author(s)
  石黒貴子、平山文俊、庵原大輔、上釜兼人
- Organizer
  第26回シクロデキストリンシンポジウム
- Place of Presentation
  栃木
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-20590050
[Presentation] Change in Crystal Habit of Aspirin by the Addition of Cyclodextrins in Aqueous Solution2008
- Author(s)
  K.Yoshida, F.Hirayama, D.Iohara, H.Arima, K.Uekama
- Organizer
  14^<th> International Cyclodextrin Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2008-05-08
- Data Source
  KAKENHI-PROJECT-20590050
[Presentation] シクロデキストリン誘導体によるアスピリン結晶の晶癖変化とその機構に関する検討2008
- Author(s)
  吉田賢史、平山文俊、庵原大輔、有馬英俊
- Organizer
  第25回日本薬学会九州支部大会
- Place of Presentation
  延岡
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PROJECT-20590050
[Presentation] Preparation of Water-Soluble C60 Nanoparticles by Co-grinding with Hydrophilic Cyclodextrin Derivatives2008
- Author(s)
  D. Iohara, F. Hirayama, K. Uekama
- Organizer
  2008 American Association of Pharmaceutical Scientists Annual Meeting and Exposition
- Place of Presentation
  Atlanta, U.S.A
- Data Source
  KAKENHI-PROJECT-19590169
[Presentation] Effects of 2-Hydroxy-butyl-β-cyclodextrin on Solution-mediated Transformation of Chlorpropamide2008
- Author(s)
  T.Ishiguro, F.Hirayama, D.Iohara, H.Arima, K.Uekama
- Organizer
  14^<th> International Cyclodextrin Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2008-05-10
- Data Source
  KAKENHI-PROJECT-20590050
[Presentation] Effects of 2-Hydroxybutyl-β-cyclodextrin on Solution-mediated Transformation of Chlorpropamide2008
- Author(s)
  T. Ishiguro, F. Hirayama, D. Iohara, K. Uekama
- Organizer
  14th International Cyclodextirn Symposium
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-19590169
[Presentation] Change in Crystal Habit of Aspirin by the Addition of Cyclodextrins in Aqueous Solution2008
- Author(s)
  K. Yoshida, F. Hirayama, D. Iohara, K. Yamaguchi, Y. Yoshitake, K. Harano, H.Arima, K. Uekama
- Organizer
  14th International Cyclodextirn Symposium
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-19590169
[Presentation] Preparation of Water-Soluble C60 Nanoparticles by Co-grinding with Hydrophilic Cyclodextrin Derivatives2008
- Author(s)
  D. Iohara, F. Hirayama, K. Uekama
- Organizer
  2008 American Association of Pharmaceutical Scientists Annual Meeting and Exposition
- Place of Presentation
  Atlanta, U.S.A.
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-19590169
[Presentation] ジメチル-β-シクロデキストリンを利用した水溶液からの非晶質性インドメタシンの調製とその溶解挙動2008
- Author(s)
  庵原大輔, 平山文俊, 上釜兼人
- Organizer
  日本薬剤学会第23年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19590169
[Presentation] ジメチル-β-シクロデキストリンを利用した水溶液からの非晶質性インドメタシンの調製とその溶解挙動2008
- Author(s)
  庵原大輔、平山文俊ヽ上釜兼人
- Organizer
  日本薬剤学会第23年会
- Place of Presentation
  札幌
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-20590050
[Presentation] Effects of β-Cyclodextrin Derivatives on Polymorphic Transition and Crystal Habit of Typical NSAIDs,Indomethacin and Aspirin2007
- Author(s)
  D.Iohara, F.Hirayama, K.Uekama
- Organizer
  4th Asian Cyclodextrin Conference
- Place of Presentation
  京都
- Year and Date
  2007-05-19
- Data Source
  KAKENHI-PROJECT-19590169
[Presentation] イソソルビドとβ-シクロデキストリンとの複合体形成
- Author(s)
  田渕良、川瀬大輝、庵原大輔、安楽誠、山口幸輝、衛藤仁、平山文俊
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-21 – 2015-05-23
- Data Source
  KAKENHI-PROJECT-26460054
[]

1. UEKAMA Kaneto (90040328)

# of Collaborated Projects: 8 results

# of Collaborated Products: 32 results
2. ARIMA Hidetoshi (50260964)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
3. IOHARA Daisuke (40454954)

# of Collaborated Projects: 3 results

# of Collaborated Products: 40 results
4. KAI Hirofumi (30194658)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. MATSUKURA Makoto (70238997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SEO Hakaru (20435142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TSURUTA Satoshi (50412739)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. IRIE Tetsumi Ph. D. (60150546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MATSUOKA Toshikazu (50150545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 竹下啓蔵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIRAYAMA Fumitoshi 平山 文俊

HIRAYAMA Fumitoshi Ph. D 平山 文俊

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Control of Crystal Polymorph Transition and Morphology Utilizing Cyclodextrin ComplexationPrincipal Investigator

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Controls of Solution-mediated Polymorphic Transition and Crystal Growth Rate Utilizing Cyclodextrin ComplexationPrincipal Investigator

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Selective Preparation of Metastable Polymorphs Utilizing Inclusion Complexation with CyclodextrinsPrincipal Investigator

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Control of Crystallization and Crystal Growth of Drug by Cyclodextrin ComplexationPrincipal Investigator

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[Book] 各種薬物の製剤特性改善におけるシクロデキストリンの有用性 in “シクロデキストリンの科学と技術”2013

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[Book] 各種薬物の製剤特性改善におけるシクロデキストリンの有用性.in"シクロデキストリンの科学と技術"2013

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Total Pages

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[Book] The Practice of Medicinal Chemistry (3^<rd> version)(Improvement of Drug Properties by Cyclodextrins)2008

Author(s)

HIRAYAMA Fumitoshi 平山文俊

HIRAYAMA Fumitoshi Ph. D 平山文俊