Tobe Takashi 戸部敞

… Alternative Names

TOBE Takashi 戸部敞

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Researcher Number	90102368
External Links
Affiliation (Current)	2025: 昭和大学, 薬学部, 名誉教授
Affiliation (based on the past Project Information) *help	2007 – 2008: Showa University, 薬学部, 教授 2003 – 2005: 昭和大学, 薬学部, 教授 2000: 昭和大, 薬学部, 教授 1998 – 2000: Showa Unv., School of Pharmaceutical Sciences, Professor, 薬学部, 教授 1997: 昭和大学, 薬学部・生理化学, 講師 1990 – 1991: 昭和大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Biological pharmacy / 膠原病・アレルギー・感染症内科学 / Biological pharmacy Except Principal Investigator Medical pharmacy / 応用薬理学・医療系薬学 / Respiratory organ internal medicine
Keywords	Principal Investigator anergy / GBP28 / LPS / Ca^<2+> responses / asthma / CD25^<high>CD4+Tregs / CD25^<high>Treg / 不応答(anergy) / アレルギー反応 / 喘息 … More / Ca流入 / Treg / CD25^<high>CD4^+CD45RO^+T細胞 / Ca^<2+>不応答性 / CD45RO^+ T細胞 / CD25^<high>CD4^+ T細胞 / Tregs / regulatory T cells / 制御性T細胞 / mutagenesis / amino acid / recombinant / CHO細胞 / 組換え体 / 脂肪細胞特異的蛋白質 / セリン / システイン / アミノ酸置換 / 変異体 / Turpentine oil, / inflammation, / IHRP, / アネキシン / STAT3 / 急性期蛋白質 / デキサメサゾン / テレピン油 / 炎症 / IHRP / PI3K / 2 / ERKl / シグナル伝達 / インスリン / アディポネクチ / アンジオテンシン IV / GLUT1 / Angiotensin II type 2 receptor / グルコース代謝 / PPAR gamma / アディポネクチン / アンジオテンシンIII … More Except Principal Investigator CD59 / MACIF / obesity / adipocyte / inflammation / coronary artery disease / diabetes mellitus / gelatin-binding / HMW (high-molecular weight) / adiponectin / 生活習慣病 / HMW(high-modecular weight) / 肥満 / 脂肪細胞 / 炎症 / 冠動脈疾患 / 糖尿病 / ゼラチン結合性 / HMV(high-molecular weight) / アディポネクチン / urine MACIF / GPl-anchored membrane protein / regulatory factor of complement / 発現ベクタ- / GPI型膜タンパク質 / 組換え型MACIF / 尿MACIF / GPI型膜蛋白質 / 補体系制御因子 / Ca^<2+> / Th2細胞 / Th1細胞 / 単球 / 酸化ストレス / 過酸化水素 / カルシウムイン / TRPM2 / 単核球 / 気管支喘息 Less

Studies on insulin-sensitive regulation by Ang IVPrincipal Investigator
- Principal Investigator
  
  TOBE Takashi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Study of adiponectin, structure, functions and clinical meanings.
- Principal Investigator
  
  NAKANO Yasuko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa University
新規活性酸素感受性チャネルTRPM2の喘息への関与及び診断の指標としての可能性
- Principal Investigator
  
  清水俊一
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Showa University
Molecular biological approach to allergy disease medical treatmentPrincipal Investigator
- Principal Investigator
  
  TOBE Takashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Showa University
The investigation of the physiological function of GBP28 which is specific for adipose tissuePrincipal Investigator
- Principal Investigator
  
  TOBE Takashi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Expression and Function of IHRPPrincipal Investigator
- Principal Investigator
  
  TOBE Takashi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Devlopment of MACIF as a new medicine for regulation of membrane attack complex of complement
- Principal Investigator
  
  TOMITA Motowo
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Showa University

All 2008 2007 2006 2005 2004 Other

All Journal Article

[Journal Article] Use of Sample hematocrit value to correct blood tacrolimus concentration derived by maicroparticle enzyme immunoassay.2008
- Author(s)
  Tomita T, Nakano Y, Tobe T, et.al.(10名)
- Journal Title
  
  Biol Pharm Bull. 31(6)
  
  Pages: 1250-1253
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590077
[Journal Article] Prg1 is regulated by the basic helix-loop-helix transcription factor Math2.2008
- Author(s)
  Yamada M, Tanioka T, Nakano Y, Tobe T, et.al.(7名)
- Journal Title
  
  J Neurochem. 106(6)
  
  Pages: 2375-2384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590077
[Journal Article] High-molecular-weight adiponectin and leptin levels in cord blood are associated with anthropometric measurements at birth.2008
- Author(s)
  Inoue M, NakanoY, Tobe T, et.al.(5名)
- Journal Title
  
  Horm Res. 70(5)
  
  Pages: 268-272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590077
[Journal Article] The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity : an association analysis in Caucasian and Japanese cohorts.2007
- Author(s)
  Ban Y, Tobe T, et.al.(7名)
- Journal Title
  
  Journal of Autoimmunity 28
  
  Pages: 201-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590077
[Journal Article] The Cardioprotective Effects of Short-term Caloric Restriction are Mediated by Adiponectin via Activation of AMP-Activated Protein Kinase.2007
- Author(s)
  Shinmura K, Nakano Y, Tobe T, et.al.(6名)
- Journal Title
  
  Circulation 116
  
  Pages: 2809-2817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590077
[Journal Article] Impact of increased plasma serotonin levels and carotid atherosclerosis on vascular dementia.2007
- Author(s)
  Ban Y, Nakano Y, Tobe T, et.al.(9名)
- Journal Title
  
  Atherosclerosis 195
  
  Pages: 153-159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590077
[Journal Article] A novel enzyme-linked immunosorbent assay specific for high-molecular weight adiponection.2006
- Author(s)
  Nakano Y, Tajima S, Yoshimi A, Akiyama H, Tsushima M, Tanioka T, Negoro T, Tomita M, Tobe T.
- Journal Title
  
  J.Lipid Research (e-pub ahead、印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590122
[Journal Article] A novel enzyme-linked immunosorbent assay specific for high-molecular weight adiponectin.2006
- Author(s)
  Nakano Y, Tajima S, Yoshimi A, Akiyama H, Tsushima M, Tanioka T, Negoro T, Tomita M, Tobe T.
- Journal Title
  
  J.Lipid Research (e-pub ahead and in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590122
[Journal Article] Comparison of serum high-molecular-weight (HMW) adiponection with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin.2006
- Author(s)
  Aso Y, Yamamoto R, akabayashi S, Uchida T, Takayanagi K, Takenayashi K, Okno T, Inoue T, Node K, Tobe T, Inukai T, Nakano Y
- Journal Title
  
  Diabetes (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590122
[Journal Article] Inhibition by adiponectin of IL-8 production by human macrophages upon coculturing with late apoptotic cells.2005
- Author(s)
  Saijo S, Nagata K, Nakano Y, Tobe T, Kobayashi Y.
- Journal Title
  
  Biochem Biophys Res Commun. 334
  
  Pages: 1180-1183
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590122
[Journal Article] 脂肪細胞特異的分泌タンパク質、アディポネクチン2005
- Author(s)
  中野泰子, 富田基郎, 八塚正四, 土岐彰, 戸部敞
- Journal Title
  
  外科と代謝・栄養 38(6)(未定)
- Data Source
  KAKENHI-PROJECT-16590122
[Journal Article] アディポネクチンとメタボリックシンドローム2005
- Author(s)
  中野泰子, 戸部敞, 富田基郎
- Journal Title
  
  昭和医学会雑誌 65
  
  Pages: 145-150
- NAID
  130001818825
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590122
[Journal Article] Inhibition by adiponection of IL-8 production by human macrophages upon coculturing with late apoptotic cells.2005
- Author(s)
  Saijo S, Nagata K, Nakano Y, Tobe T, Kobayashi Y.
- Journal Title
  
  Biochem Biophys Res Commun. 334
  
  Pages: 1180-1183
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590122
[Journal Article] Adiponectin and metabolic syndromes.2005
- Author(s)
  Nakano Y, Tobe T, Tomita M
- Journal Title
  
  J.of The Showa Medical Association 65
  
  Pages: 145-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590122
[Journal Article] アディポネクチンとメタボリックシンドローム2005
- Author(s)
  中野泰子, 戸部敞, 富田基郎
- Journal Title
  
  昭和医学会雑誌 65(2)
  
  Pages: 145-150
- NAID
  130001818825
- Data Source
  KAKENHI-PROJECT-16590122
[Journal Article] 脂肪細胞特異的分泌タンパク質、アディポネクチン2004
- Author(s)
  中野泰子, 富田基郎, 八塚正四, 土岐彰, 戸部敞
- Journal Title
  
  外科と代謝・栄養 38
  
  Pages: 165-174
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590122
[Journal Article] Adiponectin, a protein exclusively secreted by adipocytes.2004
- Author(s)
  Nakano Y, Tomita M, Yatsuduka M, Toki A, Tobe T.
- Journal Title
  
  Japanese J.of Surgical Metabolism and Nurtirion 38
  
  Pages: 165-174
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590122
[Journal Article] Comparison of serum high-molecular-weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin.
- Author(s)
  Aso Y, Yamamoto R, Wakabayashi S, Uchida T, Takayanagi K, Takebayashi K, Okno T, Inoue T, Node K, Tobe T, Inukai T, Nakano Y
- Journal Title
  
  Diabetes (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590122

1. NAKANO Yasuko (20155790)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
2. NEGORO Takaharu (70218270)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. TANIOKA Toshihiro (80360585)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. TOMITA Motowo (30102370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MIURA Namho (10146904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NARUSHIMA Michiaki (30255856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KOBA Shinji (20276546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. YATSUDUKA Masashi (20119275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 清水俊一 (60196516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 鈴木一 (80053891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 木内祐二 (50204821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 向後麻里 (70343499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. FURUICHI Kiyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAKEMOTO Toshiyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Tobe Takashi 戸部 敞

TOBE Takashi 戸部 敞

Research Projects

Research Products

Co-Researchers

Studies on insulin-sensitive regulation by Ang IVPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of adiponectin, structure, functions and clinical meanings.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新規活性酸素感受性チャネルTRPM2の喘息への関与及び診断の指標としての可能性

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular biological approach to allergy disease medical treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The investigation of the physiological function of GBP28 which is specific for adipose tissuePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Expression and Function of IHRPPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Devlopment of MACIF as a new medicine for regulation of membrane attack complex of complement

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Use of Sample hematocrit value to correct blood tacrolimus concentration derived by maicroparticle enzyme immunoassay.2008

Author(s)

Journal Title

Data Source

[Journal Article] Prg1 is regulated by the basic helix-loop-helix transcription factor Math2.2008

Author(s)

Journal Title

Data Source

[Journal Article] High-molecular-weight adiponectin and leptin levels in cord blood are associated with anthropometric measurements at birth.2008

Author(s)

Journal Title

Data Source

[Journal Article] The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity : an association analysis in Caucasian and Japanese cohorts.2007

Author(s)

Journal Title

Data Source

[Journal Article] The Cardioprotective Effects of Short-term Caloric Restriction are Mediated by Adiponectin via Activation of AMP-Activated Protein Kinase.2007

Author(s)

Journal Title

Data Source

[Journal Article] Impact of increased plasma serotonin levels and carotid atherosclerosis on vascular dementia.2007

Author(s)

Journal Title

Data Source

[Journal Article] A novel enzyme-linked immunosorbent assay specific for high-molecular weight adiponection.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] A novel enzyme-linked immunosorbent assay specific for high-molecular weight adiponectin.2006

Author(s)

Journal Title

Description

Tobe Takashi 戸部敞

TOBE Takashi 戸部敞