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Tobe Takashi  戸部 敞

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TOBE Takashi  戸部 敞

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Researcher Number 90102368
External Links
Affiliation (Current) 2025: 昭和大学, 薬学部, 名誉教授
Affiliation (based on the past Project Information) *help 2007 – 2008: Showa University, 薬学部, 教授
2003 – 2005: 昭和大学, 薬学部, 教授
2000: 昭和大, 薬学部, 教授
1998 – 2000: Showa Unv., School of Pharmaceutical Sciences, Professor, 薬学部, 教授
1997: 昭和大学, 薬学部・生理化学, 講師
1990 – 1991: 昭和大学, 薬学部, 講師
Review Section/Research Field
Principal Investigator
Biological pharmacy / 膠原病・アレルギー・感染症内科学 / Biological pharmacy
Except Principal Investigator
Medical pharmacy / 応用薬理学・医療系薬学 / Respiratory organ internal medicine
Keywords
Principal Investigator
anergy / GBP28 / LPS / Ca^<2+> responses / asthma / CD25^<high>CD4+Tregs / CD25^<high>Treg / 不応答(anergy) / アレルギー反応 / 喘息 … More / Ca流入 / Treg / CD25^<high>CD4^+CD45RO^+T細胞 / Ca^<2+>不応答性 / CD45RO^+ T細胞 / CD25^<high>CD4^+ T細胞 / Tregs / regulatory T cells / 制御性T細胞 / mutagenesis / amino acid / recombinant / CHO細胞 / 組換え体 / 脂肪細胞特異的蛋白質 / セリン / システイン / アミノ酸置換 / 変異体 / Turpentine oil, / inflammation, / IHRP, / アネキシン / STAT3 / 急性期蛋白質 / デキサメサゾン / テレピン油 / 炎症 / IHRP / PI3K / 2 / ERKl / シグナル伝達 / インスリン / アディポネクチ / アンジオテンシン IV / GLUT1 / Angiotensin II type 2 receptor / グルコース代謝 / PPAR gamma / アディポネクチン / アンジオテンシンIII … More
Except Principal Investigator
CD59 / MACIF / obesity / adipocyte / inflammation / coronary artery disease / diabetes mellitus / gelatin-binding / HMW (high-molecular weight) / adiponectin / 生活習慣病 / HMW(high-modecular weight) / 肥満 / 脂肪細胞 / 炎症 / 冠動脈疾患 / 糖尿病 / ゼラチン結合性 / HMV(high-molecular weight) / アディポネクチン / urine MACIF / GPl-anchored membrane protein / regulatory factor of complement / 発現ベクタ- / GPI型膜タンパク質 / 組換え型MACIF / 尿MACIF / GPI型膜蛋白質 / 補体系制御因子 / Ca^<2+> / Th2細胞 / Th1細胞 / 単球 / 酸化ストレス / 過酸化水素 / カルシウムイン / TRPM2 / 単核球 / 気管支喘息 Less
  • Research Projects

    (7 results)
  • Research Products

    (18 results)
  • Co-Researchers

    (14 People)
  •  Studies on insulin-sensitive regulation by Ang IVPrincipal Investigator

    • Principal Investigator
      TOBE Takashi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Showa University
  •  Study of adiponectin, structure, functions and clinical meanings.

    • Principal Investigator
      NAKANO Yasuko
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Showa University
  •  新規活性酸素感受性チャネルTRPM2の喘息への関与及び診断の指標としての可能性

    • Principal Investigator
      清水 俊一
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Showa University
  •  Molecular biological approach to allergy disease medical treatmentPrincipal Investigator

    • Principal Investigator
      TOBE Takashi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Showa University
  •  The investigation of the physiological function of GBP28 which is specific for adipose tissuePrincipal Investigator

    • Principal Investigator
      TOBE Takashi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Showa University
  •  Expression and Function of IHRPPrincipal Investigator

    • Principal Investigator
      TOBE Takashi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Showa University
  •  Devlopment of MACIF as a new medicine for regulation of membrane attack complex of complement

    • Principal Investigator
      TOMITA Motowo
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Showa University

All 2008 2007 2006 2005 2004 Other

All Journal Article

  • [Journal Article] Use of Sample hematocrit value to correct blood tacrolimus concentration derived by maicroparticle enzyme immunoassay.2008

    • Author(s)
      Tomita T, Nakano Y, Tobe T, et.al.(10名)
    • Journal Title

      Biol Pharm Bull. 31(6)

      Pages: 1250-1253

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590077
  • [Journal Article] Prg1 is regulated by the basic helix-loop-helix transcription factor Math2.2008

    • Author(s)
      Yamada M, Tanioka T, Nakano Y, Tobe T, et.al.(7名)
    • Journal Title

      J Neurochem. 106(6)

      Pages: 2375-2384

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590077
  • [Journal Article] High-molecular-weight adiponectin and leptin levels in cord blood are associated with anthropometric measurements at birth.2008

    • Author(s)
      Inoue M, NakanoY, Tobe T, et.al.(5名)
    • Journal Title

      Horm Res. 70(5)

      Pages: 268-272

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590077
  • [Journal Article] The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity : an association analysis in Caucasian and Japanese cohorts.2007

    • Author(s)
      Ban Y, Tobe T, et.al.(7名)
    • Journal Title

      Journal of Autoimmunity 28

      Pages: 201-207

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590077
  • [Journal Article] The Cardioprotective Effects of Short-term Caloric Restriction are Mediated by Adiponectin via Activation of AMP-Activated Protein Kinase.2007

    • Author(s)
      Shinmura K, Nakano Y, Tobe T, et.al.(6名)
    • Journal Title

      Circulation 116

      Pages: 2809-2817

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590077
  • [Journal Article] Impact of increased plasma serotonin levels and carotid atherosclerosis on vascular dementia.2007

    • Author(s)
      Ban Y, Nakano Y, Tobe T, et.al.(9名)
    • Journal Title

      Atherosclerosis 195

      Pages: 153-159

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590077
  • [Journal Article] A novel enzyme-linked immunosorbent assay specific for high-molecular weight adiponection.2006

    • Author(s)
      Nakano Y, Tajima S, Yoshimi A, Akiyama H, Tsushima M, Tanioka T, Negoro T, Tomita M, Tobe T.
    • Journal Title

      J.Lipid Research (e-pub ahead、印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590122
  • [Journal Article] A novel enzyme-linked immunosorbent assay specific for high-molecular weight adiponectin.2006

    • Author(s)
      Nakano Y, Tajima S, Yoshimi A, Akiyama H, Tsushima M, Tanioka T, Negoro T, Tomita M, Tobe T.
    • Journal Title

      J.Lipid Research (e-pub ahead and in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590122
  • [Journal Article] Comparison of serum high-molecular-weight (HMW) adiponection with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin.2006

    • Author(s)
      Aso Y, Yamamoto R, akabayashi S, Uchida T, Takayanagi K, Takenayashi K, Okno T, Inoue T, Node K, Tobe T, Inukai T, Nakano Y
    • Journal Title

      Diabetes (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590122
  • [Journal Article] Inhibition by adiponectin of IL-8 production by human macrophages upon coculturing with late apoptotic cells.2005

    • Author(s)
      Saijo S, Nagata K, Nakano Y, Tobe T, Kobayashi Y.
    • Journal Title

      Biochem Biophys Res Commun. 334

      Pages: 1180-1183

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590122
  • [Journal Article] 脂肪細胞特異的分泌タンパク質、アディポネクチン2005

    • Author(s)
      中野泰子, 富田基郎, 八塚正四, 土岐彰, 戸部敞
    • Journal Title

      外科と代謝・栄養 38(6)(未定)

    • Data Source
      KAKENHI-PROJECT-16590122
  • [Journal Article] アディポネクチンとメタボリックシンドローム2005

    • Author(s)
      中野泰子, 戸部敞, 富田基郎
    • Journal Title

      昭和医学会雑誌 65

      Pages: 145-150

    • NAID

      130001818825

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590122
  • [Journal Article] Inhibition by adiponection of IL-8 production by human macrophages upon coculturing with late apoptotic cells.2005

    • Author(s)
      Saijo S, Nagata K, Nakano Y, Tobe T, Kobayashi Y.
    • Journal Title

      Biochem Biophys Res Commun. 334

      Pages: 1180-1183

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590122
  • [Journal Article] Adiponectin and metabolic syndromes.2005

    • Author(s)
      Nakano Y, Tobe T, Tomita M
    • Journal Title

      J.of The Showa Medical Association 65

      Pages: 145-150

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590122
  • [Journal Article] アディポネクチンとメタボリックシンドローム2005

    • Author(s)
      中野泰子, 戸部敞, 富田基郎
    • Journal Title

      昭和医学会雑誌 65(2)

      Pages: 145-150

    • NAID

      130001818825

    • Data Source
      KAKENHI-PROJECT-16590122
  • [Journal Article] 脂肪細胞特異的分泌タンパク質、アディポネクチン2004

    • Author(s)
      中野泰子, 富田基郎, 八塚正四, 土岐彰, 戸部敞
    • Journal Title

      外科と代謝・栄養 38

      Pages: 165-174

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590122
  • [Journal Article] Adiponectin, a protein exclusively secreted by adipocytes.2004

    • Author(s)
      Nakano Y, Tomita M, Yatsuduka M, Toki A, Tobe T.
    • Journal Title

      Japanese J.of Surgical Metabolism and Nurtirion 38

      Pages: 165-174

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590122
  • [Journal Article] Comparison of serum high-molecular-weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin.

    • Author(s)
      Aso Y, Yamamoto R, Wakabayashi S, Uchida T, Takayanagi K, Takebayashi K, Okno T, Inoue T, Node K, Tobe T, Inukai T, Nakano Y
    • Journal Title

      Diabetes (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590122
  • 1.  NAKANO Yasuko (20155790)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 17 results
  • 2.  NEGORO Takaharu (70218270)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 3.  TANIOKA Toshihiro (80360585)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 4.  TOMITA Motowo (30102370)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  MIURA Namho (10146904)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  NARUSHIMA Michiaki (30255856)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KOBA Shinji (20276546)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 8.  YATSUDUKA Masashi (20119275)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  清水 俊一 (60196516)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  鈴木 一 (80053891)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  木内 祐二 (50204821)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  向後 麻里 (70343499)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  FURUICHI Kiyoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TAKEMOTO Toshiyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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