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SHIMA Hiroki  島 博基

ORCIDConnect your ORCID iD *help
Researcher Number 90104257
Other IDs
Affiliation (based on the past Project Information) *help 2014: 兵庫医科大学, 医学部, 名誉教授
1998 – 2004: the Medical Department, Hyogo College of Medicine Professor, 医学部, 教授
1997: 兵庫医科大学, 医学部, 助教授
1994 – 1995: 兵庫医科大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Urology / Urology
Except Principal Investigator
Urology / Obstetrics and gynecology / Laboratory medicine
Keywords
Principal Investigator
アンドロゲンリセプター / mutation / gene / androgen insensitivity syndrome / androgen receptor / 突然変異 / 遺伝子 / アンドロゲン不応症 / Gonadal dysgenesis / Reinfenstein syndrome … More / Androgen insensitivity / Intersex / Thermolability / Androgen receptor gene / シークエンス / インターセックス / 外性器異常 / シークェンス / インター セックス / アンドロゲン リセプター / 神経分化 / IL-18 / 転写活性 / 細胞障害 / 筋分化 / 胚性腫細胞 … More
Except Principal Investigator
cdk inhibitor / 前立腺癌 / Cervical cancer / Cell death / Gene expression / cDNA microarray / Mitotic phase / Cell cycle / 子宮頸癌 / 子宮頚癌 / 細胞死 / 遺伝子発現 / cDNAマイクロアレイ / M期 / 細胞周期 / GENE AMPLIFICATION / ANDROGEN INDEPENDENT MACHANISM / PROSTATE CANCER / 男性ホルモン受容体遺伝子 / ホルモン不応性 / 遺伝子増幅 / ホルモン耐性機構 / Historic deacetylase inhibitor / control of gene expression / cell differentiation / cell death (apoptosis) / resistance for therapy / androgen insensitivity / prostate cancer / sodium butyrate / レチノイン酸 / アポトーシス / 分化誘導 / Sp1 / ヒストンデアセチラーゼ / ヒストンデアセチラーゼ阻害剤 / 遺伝子発現調節 / cdkインヒビター / 細胞分化 / 細胞死(アポトーシス) / 治療抵抗性 / アンドロゲン非依存性 / MLPA法 / PBRM1遺伝子 / 3p21 / ヒストンアセチル化 / ゲノム不安定性 / クロマチン構造 / 易罹患性 / ゲノム多型 / HDAC阻害剤 / 転写制御 / クロマチンリモデリング / BAP1遺伝子 / 3p領域 / 悪性中皮腫 Less
  • Research Projects

    (7 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (16 People)
  •  Deletion of the 3p region in malignant mesothelioma cells derived from Japanese patients

    • Principal Investigator
      HASHIMOTO-TAMAOKI Tomoko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Hyogo Medical University
  •  胚細胞がんにおけるα-フェトプロテインの発現制御と自然治癒機構の関連Principal Investigator

    • Principal Investigator
      島 博基
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Urology
    • Research Institution
      Hyogo Medical University
  •  Analysis of the mechanisms involved in the cell cycle arrest at G2-M phases and possible clinical utility in the field of ginecology.

    • Principal Investigator
      MORINAGA Tomonori
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Hyogo College of Medicine
  •  GENE AMPLIFICATION OF ANDROGEN RECEPTOR REGION IN HORMONALLY RESISTANT PROSTATE CANCER

    • Principal Investigator
      TAKIUCHI Hidekazu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      HYOGO COLLEGE OF MEDICINE
  •  ANALYSIS ON DIFFERENTIATION MECHANISMS OF PROSTATE CANCER CELLS AND ITS APPLICATION FOR DIFFERENTIATION THERAPY AND GENE THERAPY

    • Principal Investigator
      TAMAOKI Tomoko
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      HYOGO COLLEGE OF MEDICINE
  •  Characterization of the androgen receptor (AR) in sexual differntiation to androgen insensitivity syndrome (AIS).Principal Investigator

    • Principal Investigator
      SHIMA Hiroki
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Hyogo College of Medicine
  •  Analysis of the androgen receptor gene in cases with intersex, and a trial of early diagnosis and treatment of intersex.Principal Investigator

    • Principal Investigator
      SHIMA Hiroki
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Hyogo College of Medicine

All Other

All Journal Article

  • [Journal Article] Histone deacetylase阻害剤の肝癌細胞の増殖阻止とp21^wafl遺伝子発現に対する効果

    • Author(s)
      高穎、玉置(橋本)知子、家本敦子、島博基、古山順一
    • Journal Title

      兵庫医科大学医学会雑誌 (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-11671590
  • [Journal Article] Growth Inhibition and Induction of Expression of the p21wafl Gene of Hepatoma Cells by Histone Deacetylase Inhibitors.

    • Author(s)
      Ying GAO, Jun-ichi FURUYAMA, Hiroki SHIMA, Atusko IEMOTO, Tomoko HASHIMOTO-TAMOAKI
    • Journal Title

      Acta Med. Hyogo (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-11671590
  • 1.  HASHIMOTO-TAMAOKI Tomoko (10172868)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 2 results
  • 2.  FURUYAMA Junichi (30068431)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 3.  MORINAGA Tomonori (10351818)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  NAKANO Yoshiro (30360267)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  YOSHIKAWA Reigetsu (90319864)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  TAKIUCHI Hidekazu (30206908)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  MORI Yoshinori (80131598)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  YOSHIKAWA Yoshie (10566673)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KUBO Shuji (10441320)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  EMI Mitsuru (90221118)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YOSHIOKA Masaru (90248146)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MIYAMOTO Iwai (80248145)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TSUJI Yoshiyuki (60148658)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  近藤 宣幸 (70252682)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  柳 秀憲 (50241170)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  中野 孝司 (10155781)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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