HAYASHI Toshiharu 林俊春

… Alternative Names

Researcher Number	90111484
Other IDs
Affiliation (based on the past Project Information) *help	2009 – 2011: Yamaguchi University, 農学部, 教授 1998 – 2007: 山口大学, 農学部, 教授 1995 – 1996: Yamaguchi University, Faculty of Agriculture, Professor, 農学部, 教授 1994: 山口大学, 農学部, 助教授 1990: 山口大学, 農学部, 助教授 1986 – 1988: 東京大学, 農学部, 助手
Review Section/Research Field	Principal Investigator Basic veterinary science/Basic zootechnical science / Applied veterinary science / Clinical veterinary science / Basic veterinary science/Basic zootechnical science / Applied veterinary science Except Principal Investigator 基礎獣医学 / Applied veterinary science / Basic veterinary science/Basic zootechnical science
Keywords	Principal Investigator 自己免疫疾患 / Th1 / Th2 / レオウイルス2型 / 環境因子 / 遺伝子治療 / ループス / インスリン依存型糖尿病 / アレルギー / 乳酸脱水素酵素ウイルス … More Except Principal Investigator 犬 / IL-1β / CPI-17 / FIP / マクロファ-ジ / マウス / 乳酸脱水素酵素ウイルス / インタ-ロイキン / エンドトキシン / 豚リンパ球 / インターロイキン2 / インターロイキン4 / CD4 / CD8 / スナネズミ / Tyzzer病 / 肝炎 / 腸炎 / 獣医画像診断 / 永久磁石型MRI / 体系的画像診断システム / 牛・馬 / 脳・脊髄 / 鼻腔・副鼻腔・口腔 / 関節 / 鼻腔、副鼻腔、口腔 / 獣医学 / 画像診断 / 診断システム / 神経疾患 / 胸腹部疾患 / 運動器疾患 / 放射線学的評価 / VETERINARY DIAGNOSTIC IMAGING / PERMANENT MAGNETIC TYPE MRI / SYSTEMATIC TREE FOR DIAGNOSTIC IMAGING / COW AND HORSE / DOG / BRAIN AND SPINAL CORD / NASAL,PARANASAL AND ORAL CAVITY / JOINT / α1酸性糖蛋白 / モノクローナル抗体 / L-セレクチン / 糖鎖 / 牛白血病 / E-セレクチン / シアリルルイスX抗原 / シアソルルイスX抗原 / α1-acid glycoprotein / monoclonal antibody / L-selectin / glycan chain / bovine leukemia / E-selecin / sialyl lewis X antigen / 潰瘍性大腸炎 / 消化管運動 / マクロファージ / プロテアーゼ受容体2 / 1L-1β / サイトカイン / 収縮 / ミオシンリン酸化 / ミオシンフォスファターゼ / Inflammatory Bowel Disease / gastrointestinal motility / macrophage / 家畜 / 猫 / 犬フィラリア症 / 腎炎 / フィラリヤ / 発生率 / Animals / Dod / Cat / Canine filariasis Less

Destruction of niche and target-cells in autoimmune diseases by effector cells and moleculesPrincipal Investigator
- Principal Investigator
  
  HAYASHI Toshiharu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Yamaguchi University
アレルギー性疾患の効果相における傷害臓器の決定に関する分子メカニズムPrincipal Investigator
- Principal Investigator
  
  林俊春
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Clinical veterinary science
- Research Institution
  Yamaguchi University
Mechanisms and treatments of autoimmune diseases by Th1/Th2 unbalancePrincipal Investigator
- Principal Investigator
  
  HAYASHI Toshiharu
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Yamaguchi University
Involvement of inflammatory cells on the dysmotility of gastrointestinal smooth muscles in experimental colitis model animals.
- Principal Investigator
  
  SATO Koichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Yamaguchi University
Gene therapy for autoimmune diabetes by DNA vaccinePrincipal Investigator
- Principal Investigator
  
  HAYASHI Toshiharu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Yamaguchi University
ANALYSIS OF GLYCAN CHAIN AND BINDING AFFINITY TO ADHESION MOLECULES ON ACUTE PHASE GLYCOPROTEIN IN BOVINE LEUKEMIA
- Principal Investigator
  
  IWATA Hiroyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  YAMAGUCHI UNIVERSITY
Studies on pathogenesis, prevention and treatment of serious diseases.Principal Investigator
- Principal Investigator
  
  HAYASHI Toshiharu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Yamaguchi University
レオウイルス誘導糖尿病発症におけるNOおよびO_2由来派生分子と膵島傷害との関連Principal Investigator
- Principal Investigator
  
  林俊春
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Yamaguchi University
サイトカインおよび細胞間接着分子発現による豚リンパ球の機能解析
- Principal Investigator
  
  IWATA Hiroyuki
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Yamaguchi University
DEVELOPMENT OF VETERINARY DIAGNOSTIC IMAGING TECHNIQUES WITH PERMANENT MAGNETIC TYPE MRI
- Principal Investigator
  
  TAKEUCHI Akira
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied veterinary science
- Research Institution
  IWATE UNIVERSITY
  Yamaguchi University
Relations between development of insulitis and expression of adhesion molecules in multiple low-dose streptozotocin-treated mice.Principal Investigator
- Principal Investigator
  
  HAYASHI Toshiharu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Yamaguchi University
乳酸脱水素酵素ウイルス感染マウスの免疫系とくにマクロファ-ジ機能の解析
- Principal Investigator
  
  山本春弥
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  Yamaguchi University
スナネズミにおけるTyzzer病の病理発生に関する研究
- Principal Investigator
  
  藤原公策
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  The University of Tokyo
Studies on Pathogenesis of Nephritis on Domestic Animals
- Principal Investigator
  
  TAKAHASHI Reiji
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  Azabu University
  The University of Tokyo

All 2012 2011 2010 2008 2007 2006 2005 2003

All Journal Article Book

[Book] Molecular mechanisms in allergic rhinitis : modulation by microbes, In : Advances in Medicine and Biology2012
- Author(s)
  Hayashi T.
- Data Source
  KAKENHI-PROJECT-21580362
[Book] In : Handbook of Type1 Diabetes Mellitus2010
- Author(s)
  Hayashi T.
- Publisher
  Environmental factors and concepts in the induction of type 1 diabetes
- Data Source
  KAKENHI-PROJECT-21580362
[Book] Environmental factors and concepts in the induction of type 1 diabetes2010
- Author(s)
  Toshiharu Hayashi
- Total Pages
  46
- Publisher
  Nova Science Publisheres, Inc.
- Data Source
  KAKENHI-PROJECT-21580362
[Journal Article] Destruction of salivary and lacrimal glands by Th1-polarized reaction in a model of secondary Sjogren's syndrome in Lupus-Prone female NZB□×□NZWF(1) mice2011
- Author(s)
  Hayashi T, Shimoyama N, Mizuno T.
- Journal Title
  
  Inflammation
  
  Volume: (In press)
- DOI
  10.1007/s10753-011-9356-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580362, KAKENHI-PROJECT-23380186
[Journal Article] Dysfunction of lacrimal and salivary glands in Sjogren' s syndrome : non-immunologic injury in pre-inflammatory phase and mouse2011
- Author(s)
  Hayashi T.
- Journal Title
  
  J Biomed Biotech
- DOI
  10.1155/2011/407031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580362
[Journal Article] Eosinophilic venulitis of intestine in a mouse model of late allergic rhinitis2011
- Author(s)
  Linh BK, Hayashi T, Nakasima T, T. Horii Y.
- Journal Title
  
  Inflammation
  
  Volume: 34 Pages: 499-508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580362
[Journal Article] Immunopathogenesis of distant manifestation in effector phase after a local airway allergy2011
- Author(s)
  Hayashi T.
- Journal Title
  
  Research Trends
  
  Volume: 12 Pages: 67-76
- Data Source
  KAKENHI-PROJECT-21580362
[Journal Article] Eosinophilic venulitis in the small intestines in a mouse model of late asthma2010
- Author(s)
  Linh, B.K., Hayashi, T., Nakasima, T., T.Horiii
- Journal Title
  
  Inflammation
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580362
[Journal Article] Therapeutic strategies for SLE involving cytokines : mechanism-oriented therapies especially IFN-γ targeting gene therapy2010
- Author(s)
  Hayashi, T.
- Journal Title
  
  J.Biomed.Biotech.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580362
[Journal Article] Therapeutic strategies for SLE involving cytokines : mechanism-oriented therapies especially IFN-γtargeting gene therapy2010
- Author(s)
  Hayashi T.
- Journal Title
  
  J Biomed Biotech
- DOI
  10.1155/2010/461641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580362
[Journal Article] Acute urticaria-like lesions in allergen-unexposed cutaneous tissues in a mouse model of late allergic rhinitis.2008
- Author(s)
  Hayashi T, et. al.
- Journal Title
  
  Int. J. Exp. Path. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17658142
[Journal Article] Systemic administration of olygodeoxynucleotides with CpG motifs at Priming phase reduces local Th2 response and late allergic rhinitis.2008
- Author(s)
  Hayashi T, et. al.
- Journal Title
  
  Inflammation 31
  
  Pages: 47-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17658142
[Journal Article] Reduction of late allergic eosinopbilic rbinitis by kurozu moromi powder in BALB/c mice.2007
- Author(s)
  Hayashi T, et. al.
- Journal Title
  
  Food Sci. Tech. Res. 13
  
  Pages: 385-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17658142
[Journal Article] Amelioration of late asthmatic bronchial-bronchiolar lesions in BALB/c mice by kurozu moromi powder2006
- Author(s)
  Hayashi T et al.
- Journal Title
  
  Food and Agricultural Immunology 17(1-4)
  
  Pages: 139-148
- Data Source
  KAKENHI-PROJECT-17658142
[Journal Article] Elimination of CD4^+CD25^+ T cells breaks down reovirus type 2-triggered and CpG ODN-induced prolonged mild autoimmune insulitis in DBA/1 mice.2006
- Author(s)
  Hayashi T., Hasegawa K., Sasaki Y.
- Journal Title
  
  Scand.J.Immunol. 63(2)
  
  Pages: 116-124
- Data Source
  KAKENHI-PROJECT-15380210
[Journal Article] Elimination of CD4^+CD25^+T cell enhances Reo-2-triggered and CpG oligodeoxynucleotides-induced prolonged autoimmune insulitis in DBA/1J mice.2006
- Author(s)
  Hayashi, T., Hasegawa, K., Sasaki, Y., Onodera, T.
- Journal Title
  
  Scand.J.Immunol. 163
  
  Pages: 116-124
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380210
[Journal Article] Elimination of CD4+CD25+T cell accelerate the development of glomerulonephritis during the preactive phae in lupus-prone female NZBxNZWF_1.mice.2005
- Author(s)
  Hayashi T, Hasegawa K, Adachi C
- Journal Title
  
  Int.J.Exp.Path. 86
  
  Pages: 289-296
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380210
[Journal Article] Elimination of CD4^+CD25^+ T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZBxNZWF_1 mice.2005
- Author(s)
  Hayashi, T., Hasegawa, K., Adachi, C.
- Journal Title
  
  Int.J.Exp.Path. 86
  
  Pages: 289-296
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380210
[Journal Article] ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leucocytoclastic vasculitis in NZBxNZWF_1 mice.2005
- Author(s)
  Hayashi, T., Hasegawa, K., Ichinohe, N.
- Journal Title
  
  Histol.Histpatol. 20
  
  Pages: 44-52
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380210
[Journal Article] Elimination of CD4^+CD25^+ T cell during preactive phase accerelates lupus in autoimmune-prone female B/WF_1 mice.2005
- Author(s)
  Hayashi T., Hasegawa K., Adachi C.
- Journal Title
  
  Int.J.Exp.Path. 86
  
  Pages: 289-296
- Data Source
  KAKENHI-PROJECT-15380210
[Journal Article] ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 mice.2005
- Author(s)
  Hayashi T.
- Journal Title
  
  Histol.Histopathol. 20
  
  Pages: 45-52
- Data Source
  KAKENHI-PROJECT-15380210
[Journal Article] Elimination of CD4+CD25+ regulatory T cells breaks down reovirus type b2-triggered and CpG ODN-induced prolonged mild autoimmune insulitis in DBA/1 mice.2005
- Author(s)
  Hayashi T, Hasegawa K, Sasaki Y, Onodera T
- Journal Title
  
  Scand.J.Immunol. 163
  
  Pages: 116-124
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380210
[Journal Article] II-4 expressing plasmid DNA inhibits reovirus type-2-induced autoimmune insulitis in DBA/1 mice..2003
- Author(s)
  Hayashi T, Yasutomi Y, Hasegawa K, Sasaki Y, Onodera T
- Journal Title
  
  Int.J.Exp.Pathol. 18
  
  Pages: 1-6
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380210
[Journal Article] Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZBxNZWF_1 mice.2003
- Author(s)
  Hasegawa, K., Hayashi, T.
- Journal Title
  
  Lupus 12
  
  Pages: 1-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380210
[Journal Article] Effect of antibodies to ICAM-1 and LFA-1 on cytokine mRNA expression in reo-2-triggered autoimmune insulitis in suckling DBA/1 mice.2003
- Author(s)
  Hayashi T, Hasegawa K, Morimoto M, Onodera T
- Journal Title
  
  J.Comp.Path.. 128
  
  Pages: 283-288
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380210
[Journal Article] Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis durinmg preactive phase in NZBxNZWF_1mice.2003
- Author(s)
  Hasegawa K, Hayashi T
- Journal Title
  
  Lupus 12
  
  Pages: 1-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380210
[Journal Article] IL-4 expressing plasmid DNA inhibits reovirus type-2-induced autoimmune insulitis in DBA/1J mice.2003
- Author(s)
  Hayashi, T., Yasutomi, Y., Hasegawa, K., Sasaki, Y., Onodera, T.
- Journal Title
  
  Int.J.Exp.Pathol. 84
  
  Pages: 1-6
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380210
[Journal Article] ICAM-1 expression on endothelium and systemic cytokine production in icutaneous neutrophilic leucocytoclastic vasculitis in NZBxNZWF_1mice.2003
- Author(s)
  Hayashi T, Hasegawa K, Ichinohe N
- Journal Title
  
  Histol.Histopath. 20o5
  
  Pages: 44-52
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380210
[Journal Article] Effect of antibodies to ICAM-1 and anti-LFA-1 on cytokine mRNA expression in reovirus type-2-triggered autoimmune insulitis in DBA/1 suckling mice.2003
- Author(s)
  Hayashi, T., Hasegawa, K., Morimoto, M., Onodera, T.
- Journal Title
  
  J.Comp.Pathol. 128
  
  Pages: 283-288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380210

1. IWATA Hiroyuki (40193750)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. MORIMOTO Masahiro (30274187)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. SATO Kouichi (90205914)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MAEDA Ken (90284273)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAKEUCHI Akira (90011874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OHNISHI Takafumi (60081593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAURA Yasuho (80163153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAMA Sanenori (90081596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MAKITA Takashi (90035105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KYUWA Shigeru (30177943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YASUTOMI Yasuhiro (90281724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NASU Tetsuyuki (70035559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKAHASHI Reiji (80011998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAKAYAMA Hiroyuki (40155891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 山本春弥 (70210549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 井上誠 (80035112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 藤原公策 (60012689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 後藤直彰 (70011989)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 保富康弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 水野拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAYASHI Toshiharu 林 俊春

林 俊春 ハヤシ トシハル

Research Projects

Research Products

Co-Researchers

Destruction of niche and target-cells in autoimmune diseases by effector cells and moleculesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アレルギー性疾患の効果相における傷害臓器の決定に関する分子メカニズムPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms and treatments of autoimmune diseases by Th1/Th2 unbalancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of inflammatory cells on the dysmotility of gastrointestinal smooth muscles in experimental colitis model animals.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene therapy for autoimmune diabetes by DNA vaccinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ANALYSIS OF GLYCAN CHAIN AND BINDING AFFINITY TO ADHESION MOLECULES ON ACUTE PHASE GLYCOPROTEIN IN BOVINE LEUKEMIA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on pathogenesis, prevention and treatment of serious diseases.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

レオウイルス誘導糖尿病発症におけるNOおよびO_2由来派生分子と膵島傷害との関連Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

サイトカインおよび細胞間接着分子発現による豚リンパ球の機能解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DEVELOPMENT OF VETERINARY DIAGNOSTIC IMAGING TECHNIQUES WITH PERMANENT MAGNETIC TYPE MRI

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Relations between development of insulitis and expression of adhesion molecules in multiple low-dose streptozotocin-treated mice.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

乳酸脱水素酵素ウイルス感染マウスの免疫系とくにマクロファ-ジ機能の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

スナネズミにおけるTyzzer病の病理発生に関する研究

Principal Investigator

Project Period (FY)

HAYASHI Toshiharu 林俊春

林俊春ハヤシトシハル