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HAYASHI Toshiharu  林 俊春

ORCIDConnect your ORCID iD *help
… Alternative Names

林 俊春  ハヤシ トシハル

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Researcher Number 90111484
Other IDs
Affiliation (based on the past Project Information) *help 2009 – 2011: Yamaguchi University, 農学部, 教授
1998 – 2007: 山口大学, 農学部, 教授
1995 – 1996: Yamaguchi University, Faculty of Agriculture, Professor, 農学部, 教授
1994: 山口大学, 農学部, 助教授
1990: 山口大学, 農学部, 助教授
1986 – 1988: 東京大学, 農学部, 助手
Review Section/Research Field
Principal Investigator
Basic veterinary science/Basic zootechnical science / Applied veterinary science / Clinical veterinary science / Basic veterinary science/Basic zootechnical science / Applied veterinary science
Except Principal Investigator
基礎獣医学 / Applied veterinary science / Basic veterinary science/Basic zootechnical science
Keywords
Principal Investigator
自己免疫疾患 / Th1 / Th2 / レオウイルス2型 / 環境因子 / 遺伝子治療 / ループス / インスリン依存型糖尿病 / アレルギー / 乳酸脱水素酵素ウイルス … More / 遅発型 / 全身性エリテマトーデス / 喘息 / 自己寛容 / レオウイルス / 膵島炎 / Insulitis / Gene therapy / CD4^+CD25^+T cell / 耐糖能異常 / マウス / 膵島細胞傷害 / Dimethylthiourea / ヒドロキシルラジカル / 鼻炎 / 即時型反応 / 遅発型反応 / 皮膚炎 / Th2反応 / 病態 / 気管支炎 / 自然食品 / 抗原提示 / Th2バランス / 1型糖尿病 / シェーグレン症候群 / モデル / アレルギー性喘息 / 病理発生 / Niche / インターフェロンγ / 腸 / 好酸球性血管炎 / 概念 / メカニズム / β細胞 / ストレプトゾトシン / ICAM-1 / I型糖尿病 / LFA-1 / 2型レオウイルス / LDV / 血管内皮細胞 / IDDM / ICAM-I / LFA-I / type 2 reovirus / Autoimmune disease / Streptozotocin / SLE / 馬ヘルペスウイルス / イバラキウイルス / 疫学 / Th1細胞 / クローニング / 遺伝子 / マウスモデル / 膵島細胞破壊 / IFN-Υ / lactic dehydrogenase virus / equine herpes virus / Ibaraki virus / epizootiology / Th1 cell / cloning / reovirus / gene / 自己免疫性糖尿病 / インターフェロンーガンマ / IL-4 / IL-18 / IL-12 / DNAワクチン / レオウイルスー2型 / 自己免疫 / 唾液腺炎 / ラミニン / アレルギー性気管支炎 / Reovirus type-2 / Autoimmune diabetes / 糖尿病 / CD4^+D25^+T細胞 / CpGモチーフ / ウイルス / 接着分子 / 治療 / diabetes / lupus / tolerance / autoimmune diseases … More
Except Principal Investigator
犬 / IL-1β / CPI-17 / FIP / マクロファ-ジ / マウス / 乳酸脱水素酵素ウイルス / インタ-ロイキン / エンドトキシン / 豚リンパ球 / インターロイキン2 / インターロイキン4 / CD4 / CD8 / スナネズミ / Tyzzer病 / 肝炎 / 腸炎 / 獣医画像診断 / 永久磁石型MRI / 体系的画像診断システム / 牛・馬 / 脳・脊髄 / 鼻腔・副鼻腔・口腔 / 関節 / 鼻腔、副鼻腔、口腔 / 獣医学 / 画像診断 / 診断システム / 神経疾患 / 胸腹部疾患 / 運動器疾患 / 放射線学的評価 / VETERINARY DIAGNOSTIC IMAGING / PERMANENT MAGNETIC TYPE MRI / SYSTEMATIC TREE FOR DIAGNOSTIC IMAGING / COW AND HORSE / DOG / BRAIN AND SPINAL CORD / NASAL,PARANASAL AND ORAL CAVITY / JOINT / α1酸性糖蛋白 / モノクローナル抗体 / L-セレクチン / 糖鎖 / 牛白血病 / E-セレクチン / シアリルルイスX抗原 / シアソルルイスX抗原 / α1-acid glycoprotein / monoclonal antibody / L-selectin / glycan chain / bovine leukemia / E-selecin / sialyl lewis X antigen / 潰瘍性大腸炎 / 消化管運動 / マクロファージ / プロテアーゼ受容体2 / 1L-1β / サイトカイン / 収縮 / ミオシンリン酸化 / ミオシンフォスファターゼ / Inflammatory Bowel Disease / gastrointestinal motility / macrophage / 家畜 / 猫 / 犬フィラリア症 / 腎炎 / フィラリヤ / 発生率 / Animals / Dod / Cat / Canine filariasis Less
  • Research Projects

    (14 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (20 People)
  •  Destruction of niche and target-cells in autoimmune diseases by effector cells and moleculesPrincipal Investigator

    • Principal Investigator
      HAYASHI Toshiharu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      Yamaguchi University
  •  アレルギー性疾患の効果相における傷害臓器の決定に関する分子メカニズムPrincipal Investigator

    • Principal Investigator
      林 俊春
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Clinical veterinary science
    • Research Institution
      Yamaguchi University
  •  Mechanisms and treatments of autoimmune diseases by Th1/Th2 unbalancePrincipal Investigator

    • Principal Investigator
      HAYASHI Toshiharu
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied veterinary science
    • Research Institution
      Yamaguchi University
  •  Involvement of inflammatory cells on the dysmotility of gastrointestinal smooth muscles in experimental colitis model animals.

    • Principal Investigator
      SATO Koichi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      Yamaguchi University
  •  Gene therapy for autoimmune diabetes by DNA vaccinePrincipal Investigator

    • Principal Investigator
      HAYASHI Toshiharu
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied veterinary science
    • Research Institution
      Yamaguchi University
  •  ANALYSIS OF GLYCAN CHAIN AND BINDING AFFINITY TO ADHESION MOLECULES ON ACUTE PHASE GLYCOPROTEIN IN BOVINE LEUKEMIA

    • Principal Investigator
      IWATA Hiroyuki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied veterinary science
    • Research Institution
      YAMAGUCHI UNIVERSITY
  •  Studies on pathogenesis, prevention and treatment of serious diseases.Principal Investigator

    • Principal Investigator
      HAYASHI Toshiharu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied veterinary science
    • Research Institution
      Yamaguchi University
  •  レオウイルス誘導糖尿病発症におけるNOおよびO_2由来派生分子と膵島傷害との関連Principal Investigator

    • Principal Investigator
      林 俊春
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      Yamaguchi University
  •  サイトカインおよび細胞間接着分子発現による豚リンパ球の機能解析

    • Principal Investigator
      IWATA Hiroyuki
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied veterinary science
    • Research Institution
      Yamaguchi University
  •  DEVELOPMENT OF VETERINARY DIAGNOSTIC IMAGING TECHNIQUES WITH PERMANENT MAGNETIC TYPE MRI

    • Principal Investigator
      TAKEUCHI Akira
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Applied veterinary science
    • Research Institution
      IWATE UNIVERSITY
      Yamaguchi University
  •  Relations between development of insulitis and expression of adhesion molecules in multiple low-dose streptozotocin-treated mice.Principal Investigator

    • Principal Investigator
      HAYASHI Toshiharu
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      Yamaguchi University
  •  乳酸脱水素酵素ウイルス感染マウスの免疫系とくにマクロファ-ジ機能の解析

    • Principal Investigator
      山本 春弥
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      基礎獣医学
    • Research Institution
      Yamaguchi University
  •  スナネズミにおけるTyzzer病の病理発生に関する研究

    • Principal Investigator
      藤原 公策
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      基礎獣医学
    • Research Institution
      The University of Tokyo
  •  Studies on Pathogenesis of Nephritis on Domestic Animals

    • Principal Investigator
      TAKAHASHI Reiji
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      基礎獣医学
    • Research Institution
      Azabu University
      The University of Tokyo

All 2012 2011 2010 2008 2007 2006 2005 2003

All Journal Article Book

  • [Book] Molecular mechanisms in allergic rhinitis : modulation by microbes, In : Advances in Medicine and Biology2012

    • Author(s)
      Hayashi T.
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Book] In : Handbook of Type1 Diabetes Mellitus2010

    • Author(s)
      Hayashi T.
    • Publisher
      Environmental factors and concepts in the induction of type 1 diabetes
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Book] Environmental factors and concepts in the induction of type 1 diabetes2010

    • Author(s)
      Toshiharu Hayashi
    • Total Pages
      46
    • Publisher
      Nova Science Publisheres, Inc.
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Journal Article] Destruction of salivary and lacrimal glands by Th1-polarized reaction in a model of secondary Sjogren's syndrome in Lupus-Prone female NZB□×□NZWF(1) mice2011

    • Author(s)
      Hayashi T, Shimoyama N, Mizuno T.
    • Journal Title

      Inflammation

      Volume: (In press)

    • DOI

      10.1007/s10753-011-9356-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21580362, KAKENHI-PROJECT-23380186
  • [Journal Article] Dysfunction of lacrimal and salivary glands in Sjogren' s syndrome : non-immunologic injury in pre-inflammatory phase and mouse2011

    • Author(s)
      Hayashi T.
    • Journal Title

      J Biomed Biotech

    • DOI

      10.1155/2011/407031

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Journal Article] Eosinophilic venulitis of intestine in a mouse model of late allergic rhinitis2011

    • Author(s)
      Linh BK, Hayashi T, Nakasima T, T. Horii Y.
    • Journal Title

      Inflammation

      Volume: 34 Pages: 499-508

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Journal Article] Immunopathogenesis of distant manifestation in effector phase after a local airway allergy2011

    • Author(s)
      Hayashi T.
    • Journal Title

      Research Trends

      Volume: 12 Pages: 67-76

    • Data Source
      KAKENHI-PROJECT-21580362
  • [Journal Article] Eosinophilic venulitis in the small intestines in a mouse model of late asthma2010

    • Author(s)
      Linh, B.K., Hayashi, T., Nakasima, T., T.Horiii
    • Journal Title

      Inflammation

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Journal Article] Therapeutic strategies for SLE involving cytokines : mechanism-oriented therapies especially IFN-γ targeting gene therapy2010

    • Author(s)
      Hayashi, T.
    • Journal Title

      J.Biomed.Biotech.

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Journal Article] Therapeutic strategies for SLE involving cytokines : mechanism-oriented therapies especially IFN-γtargeting gene therapy2010

    • Author(s)
      Hayashi T.
    • Journal Title

      J Biomed Biotech

    • DOI

      10.1155/2010/461641

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21580362
  • [Journal Article] Acute urticaria-like lesions in allergen-unexposed cutaneous tissues in a mouse model of late allergic rhinitis.2008

    • Author(s)
      Hayashi T, et. al.
    • Journal Title

      Int. J. Exp. Path. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17658142
  • [Journal Article] Systemic administration of olygodeoxynucleotides with CpG motifs at Priming phase reduces local Th2 response and late allergic rhinitis.2008

    • Author(s)
      Hayashi T, et. al.
    • Journal Title

      Inflammation 31

      Pages: 47-56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17658142
  • [Journal Article] Reduction of late allergic eosinopbilic rbinitis by kurozu moromi powder in BALB/c mice.2007

    • Author(s)
      Hayashi T, et. al.
    • Journal Title

      Food Sci. Tech. Res. 13

      Pages: 385-390

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17658142
  • [Journal Article] Amelioration of late asthmatic bronchial-bronchiolar lesions in BALB/c mice by kurozu moromi powder2006

    • Author(s)
      Hayashi T et al.
    • Journal Title

      Food and Agricultural Immunology 17(1-4)

      Pages: 139-148

    • Data Source
      KAKENHI-PROJECT-17658142
  • [Journal Article] Elimination of CD4^+CD25^+ T cells breaks down reovirus type 2-triggered and CpG ODN-induced prolonged mild autoimmune insulitis in DBA/1 mice.2006

    • Author(s)
      Hayashi T., Hasegawa K., Sasaki Y.
    • Journal Title

      Scand.J.Immunol. 63(2)

      Pages: 116-124

    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Elimination of CD4^+CD25^+T cell enhances Reo-2-triggered and CpG oligodeoxynucleotides-induced prolonged autoimmune insulitis in DBA/1J mice.2006

    • Author(s)
      Hayashi, T., Hasegawa, K., Sasaki, Y., Onodera, T.
    • Journal Title

      Scand.J.Immunol. 163

      Pages: 116-124

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Elimination of CD4+CD25+T cell accelerate the development of glomerulonephritis during the preactive phae in lupus-prone female NZBxNZWF_1.mice.2005

    • Author(s)
      Hayashi T, Hasegawa K, Adachi C
    • Journal Title

      Int.J.Exp.Path. 86

      Pages: 289-296

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Elimination of CD4^+CD25^+ T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZBxNZWF_1 mice.2005

    • Author(s)
      Hayashi, T., Hasegawa, K., Adachi, C.
    • Journal Title

      Int.J.Exp.Path. 86

      Pages: 289-296

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leucocytoclastic vasculitis in NZBxNZWF_1 mice.2005

    • Author(s)
      Hayashi, T., Hasegawa, K., Ichinohe, N.
    • Journal Title

      Histol.Histpatol. 20

      Pages: 44-52

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Elimination of CD4^+CD25^+ T cell during preactive phase accerelates lupus in autoimmune-prone female B/WF_1 mice.2005

    • Author(s)
      Hayashi T., Hasegawa K., Adachi C.
    • Journal Title

      Int.J.Exp.Path. 86

      Pages: 289-296

    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 mice.2005

    • Author(s)
      Hayashi T.
    • Journal Title

      Histol.Histopathol. 20

      Pages: 45-52

    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Elimination of CD4+CD25+ regulatory T cells breaks down reovirus type b2-triggered and CpG ODN-induced prolonged mild autoimmune insulitis in DBA/1 mice.2005

    • Author(s)
      Hayashi T, Hasegawa K, Sasaki Y, Onodera T
    • Journal Title

      Scand.J.Immunol. 163

      Pages: 116-124

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] II-4 expressing plasmid DNA inhibits reovirus type-2-induced autoimmune insulitis in DBA/1 mice..2003

    • Author(s)
      Hayashi T, Yasutomi Y, Hasegawa K, Sasaki Y, Onodera T
    • Journal Title

      Int.J.Exp.Pathol. 18

      Pages: 1-6

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZBxNZWF_1 mice.2003

    • Author(s)
      Hasegawa, K., Hayashi, T.
    • Journal Title

      Lupus 12

      Pages: 1-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Effect of antibodies to ICAM-1 and LFA-1 on cytokine mRNA expression in reo-2-triggered autoimmune insulitis in suckling DBA/1 mice.2003

    • Author(s)
      Hayashi T, Hasegawa K, Morimoto M, Onodera T
    • Journal Title

      J.Comp.Path.. 128

      Pages: 283-288

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis durinmg preactive phase in NZBxNZWF_1mice.2003

    • Author(s)
      Hasegawa K, Hayashi T
    • Journal Title

      Lupus 12

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] ICAM-1 expression on endothelium and systemic cytokine production in icutaneous neutrophilic leucocytoclastic vasculitis in NZBxNZWF_1mice.2003

    • Author(s)
      Hayashi T, Hasegawa K, Ichinohe N
    • Journal Title

      Histol.Histopath. 20o5

      Pages: 44-52

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] IL-4 expressing plasmid DNA inhibits reovirus type-2-induced autoimmune insulitis in DBA/1J mice.2003

    • Author(s)
      Hayashi, T., Yasutomi, Y., Hasegawa, K., Sasaki, Y., Onodera, T.
    • Journal Title

      Int.J.Exp.Pathol. 84

      Pages: 1-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • [Journal Article] Effect of antibodies to ICAM-1 and anti-LFA-1 on cytokine mRNA expression in reovirus type-2-triggered autoimmune insulitis in DBA/1 suckling mice.2003

    • Author(s)
      Hayashi, T., Hasegawa, K., Morimoto, M., Onodera, T.
    • Journal Title

      J.Comp.Pathol. 128

      Pages: 283-288

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380210
  • 1.  IWATA Hiroyuki (40193750)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  MORIMOTO Masahiro (30274187)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  SATO Kouichi (90205914)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  MAEDA Ken (90284273)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  TAKEUCHI Akira (90011874)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  OHNISHI Takafumi (60081593)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  TAURA Yasuho (80163153)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  NAKAMA Sanenori (90081596)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  MAKITA Takashi (90035105)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KYUWA Shigeru (30177943)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YASUTOMI Yasuhiro (90281724)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  NASU Tetsuyuki (70035559)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TAKAHASHI Reiji (80011998)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  NAKAYAMA Hiroyuki (40155891)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  山本 春弥 (70210549)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  井上 誠 (80035112)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  藤原 公策 (60012689)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  後藤 直彰 (70011989)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  保富 康弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 20.  水野 拓也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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