TOJYO Yosuke 東城庸介

Researcher Number	90111731
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2000 – 2014: 北海道医療大学, 歯学部, 教授 1993 – 1998: 北海道医療大学, 歯学部, 助教授 1991 – 1992: 東日本学園大学, 歯学部, 助教授 1988 – 1989: 東日本学園大学, 歯学部, 助教授
Review Section/Research Field	Principal Investigator Functional basic dentistry / Functional basic dentistry Except Principal Investigator Functional basic dentistry
Keywords	Principal Investigator 唾液腺 / GFP / 耳下腺細胞 / 細胞内カルシウムイオン / カルシウムシグナル / イメージング / イノシトール1,4,5-三リン酸 / アミラーゼ分泌 / 耳下腺 / LIBRA … More / イノシトール三リン酸 / FRET / calcium signal / fura-2 / calcium ion / 開口分泌 / カルシウムウエーブ / カルシウムイオン / 腺房細胞 / Intracellular Ca^<2+> / Parotid cells / 細胞内カルシウムストア / Purinergic receptor / ホスファターゼ阻害薬 / プリン受容体 / Protein kinase C / Intracellular calcium / Parotid gland / 細胞内情報伝達 / アミラ-ゼ分泌 / プロテインキナーゼC / 細胞内カルシウム / カリウム放出 / Calmodulin Antagonists / Calcium / Calcium Chelator / Exocytosis / Amylase Secretion / Calmodulin / Salivary Glands / Parotid Glands / サイクリックAMP / カルシウム・キレ-ト剤 / カルモジュリン阻害薬 / カルシウムキレ-ト剤 / カルシウム / カルモジュリン / fluorescent imaging / inositol 1, 4, 5-trisphosphate / salivary glands / 蛍光イメージング / tissue slices / acinar cells / duct cells / calcium wave / salivary gland / multiphoton laser microscopy / カルシウムストア / レーザー顕微鏡 / 多光子励起法 / エピネフリン / 組織スライス / 導管細胞 / 多光子レーザー顕微鏡 / SNARE proteins / C-kinase / Ca^<2+> wave / imaging / inositol 1,4,5-trisphosphateimaging / salivary cells / SNARE蛋白貭 / 可視化 / Cキナーゼ / イノシトール1,4,5-ミリン酸 / SNARE蛋白質 / C-キナーゼ / 唾液腺細胞 / Ca^<2+> imaging / Intracellular Ca^<2+> store / Inositol-1,4,5-trisphosphate / Calcium signal / Acinar cells / リアノジン受容体 / カルシウムウェーブ / β受容体 / イソプロテレノール / Ca^<2+>ウェーブ / カルシウムイメージング / イノツトール1, 4, 5-ミリン酸 / Phosphatase inhibitors / Kinase inhibitor / Intracellular Ca^<2+> stores / Capacitative Ca^<2+> entry / プロテイン・ホスファターゼ / プロテインキナーゼ / カルシウムチャンネル / 細胞内カルシウム動態 / カルシウム流入 / キナーゼ阻害薬 / 容量性カルシウム流入 / muscarinic receptor / Pottassium release / Cross-talk / Intracellular signaling / スタウロスポリン / ホルボールエステル / サイフリックAMP / 細胞外ATP / ムスカリン受容体 / クロストーク / Stimulation-secretion coupling / Fluid secretion / Potassium release / Amylase release / Salivary gland / セカンドメッセンジャ- / プロテインキナ-ゼC / 刺激ー分泌連関 / カルシウム動員 / セカンドメッセンジァー / K^+放出 / 刺激-分泌連関 / プロティンキナーゼC / 水分泌 / Ca^<2+> / IP_3 / 蛍光分子センサー / 顎下腺 / Ca^ / IP^ / YFP / CFP … More Except Principal Investigator イノシトール三リン酸 / イメージング / カルシウム / 蛍光タンパク質 / 唾液腺 / inositol 1,4,5-trisphosphate receptor / imaging / screening / intracellular calcium ion / fluorescent proteins / fluorescent probe / fluorescent resonance energy transfer / inositol 1,4,5-trisphosphate / IP3受容体 / calcium / IP_3受容体 / FRET / イノシトール三燐酸 / イノシトール1,4,5三リン酸受容体 / スクリーニング / 細胞内カルシウム / 蛍光プローブ / 蛍光共鳴エネルギー移動 / イノシトール1,4,5三リン酸 / サイクリックAMP / 口腔乾燥症 / 蛍光イメージング / 発光センサー / 唾液分泌 / カルシウムシグナル / ウイルスベクター / 遺伝子導入 / 血流 / in vivo / 蛍光蛋白質 / プリン受容体 / 分泌 / 導管 / 歯科薬理学 Less

Intravital imaging study for the regulation of salivary gland functions
- Principal Investigator
  
  TANIMURA Akihiko
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido
Analysis of spatiotemporal pattern in IP^ production in submandibulargland using fluorescent-biosenseorPrincipal Investigator
- Principal Investigator
  
  TOJYO Yosuke
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido
Imaging analysis of the electrolyte transport and protein secretions in salivary ducts to reveal their regulatory mechanisms
- Principal Investigator
  
  TANIMURA Akihiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido
Visualization of spatio-temporal pattern of IP3/Ca2+ signaling in salivary glandsPrincipal Investigator
- Principal Investigator
  
  TOJYO Yosuke
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido,
STUDIES ON THE DYNAMICS OF PHOSPHOINOSITIDE PATHWAYS AND THE DEVELOPMENT OF FLUORESCENT BIOSENSORS
- Principal Investigator
  
  TANIMURA Akihiko
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido
Real-time monitoring of cellular signaling in salivary secretion by multiphoton excitation imagingPrincipal Investigator
- Principal Investigator
  
  TOJYO Yosuke
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido, School of Dentistry
蛍光共鳴エネルギー転移を応用したイノシトール三リン酸の細胞内動態のイメージングPrincipal Investigator
- Principal Investigator
  
  東城庸介
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido
Imaging of the signal molecules mediating secretory responses in salivary gland cellsPrincipal Investigator
- Principal Investigator
  
  TOJYO Yosuke
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido
Imaging of chnages in intracellular ion distribution induced by receptor stimulation in parotid aciner cellsPrincipal Investigator
- Principal Investigator
  
  TOJYO Yosuke
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido, School of Dentistry
Molecular mechanism of the receptor-mediated Ca^<2+> entry in parotid cellsPrincipal Investigator
- Principal Investigator
  
  TOJYO Yosuke
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido, School of Dentistry
The cross-talk and secretion in intracellular signaling in parotid glandsPrincipal Investigator
- Principal Investigator
  
  TOJYO Yosuke
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido, School of Dentistry
The physiological role and the control mechanism of Ca^<2+>-mobilization in stimulation-secretion coupling in parotid glandPrincipal Investigator
- Principal Investigator
  
  TOJYO Yosuke
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Higashi-Nippon-Gakuen University, School of Dentistry
The Physiological Role of Calmodulin in Rat Parotid Amylase ReleasePrincipal Investigator
- Principal Investigator
  
  TOJYO Yosuke
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Higashi-Nippon-Gakuen University, School of Dentistry

All 2015 2014 2013 2012 2011 2010 2009 2008 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] Partial agonistic effects of pilocarpine on Ca2+ responses and salivary secretion in the submandibular glands of live animals.2015
- Author(s)
  Akihiro Nezu, Takao Morita, Yosuke Tojyo, Takeharu Nagai, and Akihiko Tanimura
- Journal Title
  
  Experimental Physiology
  
  Volume: in press Issue: 6 Pages: 640-651
- DOI
  10.1113/ep085110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390425, KAKENHI-PROJECT-26462821, KAKENHI-PROJECT-26462820, KAKENHI-PLANNED-23115003, KAKENHI-PROJECT-26670812
[Journal Article] A fluorescence-based method for evaluating inositol 1,4,5-trisphosphate receptor ligands: Determination of subtype selectivity and partial agonist effects.2013
- Author(s)
  Tanimura A, Mochizuki T, Morita T, Nezu A, Tojyo Y, Arisawa M, Shuto S.
- Journal Title
  
  J Biotechnol.
  
  Volume: 167 Pages: 248-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390425
[Journal Article] Staurosporine maintains the activation of store-operated Ca2+ entry even after the refilling of Ca2+ stores.2013
- Author(s)
  Yosuke Tojyo
- Journal Title
  
  Cell Calcium
  
  Volume: 54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592073
[Journal Article] Increase in muscarinic stimulation-induced Ca2+ response by adenovirus-mediated Stim1-mKO1 gene transfer to rat submandibular acinar cells in vivo.2013
- Author(s)
  Morita T, Nezu A, Tojyo Y, Tanimura A
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 39 Issue: 4 Pages: 433-437
- DOI
  10.1016/j.bbrc.2013.08.080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390425, KAKENHI-PROJECT-23592745
[Journal Article] Staurosporinemaintains the activation ofstore-operated Ca^ entry even after therefilling of Ca^ stores2013
- Author(s)
  Yosuke Tojyo, Takao Morita, AkihiroNezu, Akihiko Tanimura
- Journal Title
  
  Cell Calcium
  
  Volume: 53 Pages: 349-356
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592073
[Journal Article] Staurosporine maintains the activation of store-operated Ca^ entry even after the refilling of Ca^ stores2013
- Author(s)
  Tojyo Y, Morita T, Nezu A, Tanimura A
- Journal Title
  
  Cell Calcium
  
  Volume: (in press) Issue: 5-6 Pages: 349-356
- DOI
  10.1016/j.ceca.2013.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592075, KAKENHI-PROJECT-23390425, KAKENHI-PROJECT-23592745
[Journal Article] Expressionof functional Stim1-mKO1 in ratsubmandibular acinar cells by retrogardeductal injection of an adenoviral vector2011
- Author(s)
  Takao Morita, Akihiko Tanimura, AkikoShitara, Yuko Suzuki, Akihiro Nezu,Taishin Takuma, Yosuke Tojyo
- Journal Title
  
  Archs Oral Biol
  
  Volume: 56 Pages: 1356-1365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592073
[Journal Article] Diversity and spactio-temporal proterties of calcium responses in salivary ducts2011
- Author(s)
  Tanimura A, Shitara A, and Tojyo Y.
- Journal Title
  
  J Oral Biosci
  
  Volume: 53 Pages: 48-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592180
[Journal Article] Expression of functional Stiml-mKO1 in rat submandibular acinar cells by retrograde ductal injection of adenoviral vector2011
- Author(s)
  Morita T, Tanimura A, Shitara A, Suzuki Y, Nezu A, Takuma T, and Tojyo Y.
- Journal Title
  
  Arch Oral Biol
  
  Volume: 56 Pages: 1356-1365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592180
[Journal Article] Visualization of Ins(1, 4, 5) P_3 dynamics in living cells : two distinct pathways for Ins(1, 4, 5) P_3 generation following mechanical stimulation of HSY-EA1 cells2010
- Author(s)
  Nezu A, Tanimura A, Morita T, and Tojyo Y.
- Journal Title
  
  J Cell Sci
  
  Volume: 123 Pages: 2292-2298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592180
[Journal Article] Visualization of Ins(1,4,5) P3 dynamics in living cells : two distinct pathways for Ins(1,4,5)P3 generation following mechanical stimulation of HSY-EA12010
- Author(s)
  Nezu A, Tanimura A, Morita T, Tojyo Y.
- Journal Title
  
  Journal of Cell Science
  
  Volume: 123 Pages: 2292-2298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592180
[Journal Article] Spontaneous oscillations in intracellular Ca^<2+>_ concentration via purinergic receptors elicit transient cell swelling in rat parotid ducts.2009
- Author(s)
  Shitara A, Tanimura A, Sato A, Tojyo Y.
- Journal Title
  
  Am.J.Physiol.Gastrointest.Liver physiol.
  
  Volume: 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592180
[Journal Article] Spontaneous oscillations in intracellular Ca^<2+> concentration via purinergic receptors elicit transient cell swelling in rat parotid ducts2009
- Author(s)
  Shitara A, Tanimura A, Sato A, and Tojyo Y.
- Journal Title
  
  Am J Physiol
  
  Volume: 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592180
[Journal Article] Use of fluorescence resonance energy transfer-based biosensors for the quantitative analysis of inositol 1, 4, 5-trisphosphate dynamics in calcium oscillations2009
- Author(s)
  Tanimura A, Morita T, Nezu A, Shitara A, Hashimoto N, and Tojyo Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 284 Pages: 8910-8917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592180
[Journal Article] A Stiml-dependent, noncapacitative Ca^<2+>-entry pathway is activated by B-cellreceptor stimulation and depletion of Ca^<2+>2009
- Author(s)
  Morita T, Tanimura A, Baba B, Kurosaki T, and Tojyo Y.
- Journal Title
  
  J Cell Sci
  
  Volume: 122 Pages: 1220-1228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592180
[Journal Article] The clustering of inositol 1,4,5-trisphosphate (IP_3) receptors is triggered by IP_3 binding and facilitated by depletion of the Ca^<2+> store.2008
- Author(s)
  Yosuke Tojyo
- Journal Title
  
  Journal of Pharmacological Sciences 107
  
  Pages: 138-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390532
[Journal Article] The clustering of inositol1, 4, 5-trisphosphate(IP_3)receptors is triggered by IP_3 binding and facilitated by depletion of the Ca^<2+> store.2008
- Author(s)
  Yosuke Tojyo
- Journal Title
  
  Journal of Pharmacological Sciences 107
  
  Pages: 138-150
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390532
[Journal Article] A novel fluorescent method employing the FRET-based biosensor "LIBRA" for the identification of ligands of the inositol 1,4,5-triphosphate receptors2006
- Author(s)
  A.Nezu, A.Tanimura, T.Morita, A.Shitara, Y.Tojyo
- Journal Title
  
  Biochemica et Biophysica Acta 1760
  
  Pages: 1274-1280
- Data Source
  KAKENHI-PROJECT-17591946
[Journal Article] A novel fluorescent method employing the FRET-based biosensor "LIBRA" for the identification of ligands of the inositol 1,4,5-trisphosphate receptors2006
- Author(s)
  A.Nezu, A.Tanimura, T.Morita, A.Shitara, Y.Tojyo
- Journal Title
  
  Biochimica et Biophysica Acta 1760
  
  Pages: 1274-1280
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591946
[Journal Article] 唾液分泌とシグナルトランスダクション2006
- Author(s)
  谷村明彦, 東城庸介
- Journal Title
  
  日本薬理学雑誌 127
  
  Pages: 249-255
- NAID
  10019252092
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591946
[Journal Article] Regulation of fluid and electrolyte secretion and exocytosis in salivary acinar cells.2006
- Author(s)
  Tanimura, A., Tojyo, Y.
- Journal Title
  
  Folia Pharmacology of Japan 127
  
  Pages: 249-255
- NAID
  10019252092
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591946
[Journal Article] 唾液分泌とシグナルトランスダクション2006
- Author(s)
  谷村明彦, 東城庸介
- Journal Title
  
  日本薬理学会雑誌 127
  
  Pages: 249-255
- NAID
  10019252092
- Data Source
  KAKENHI-PROJECT-17591946
[Journal Article] A nobel fluorescent method employing the FRET-based biosensor "LIBRA" for the identification of ligands of the inositol 1,4,5-trisphosphate receptors.2006
- Author(s)
  Nezu, A., Tanimura, A., Morita, T, Shitara, A., Tojyo, Y.
- Journal Title
  
  Biochimca et Biophysca Acta 1760
  
  Pages: 1274-1280
- Data Source
  KAKENHI-PROJECT-16390532
[Journal Article] A novel fluorescent method employing the FRET-based biosensor "LIBRA" for the identification of the inositol 1,4,5-trisphosphate receptors.2006
- Author(s)
  Nezu, A., Tanimura, A., Morita, T., Shitara, A., Tojyo.Y.
- Journal Title
  
  Biochimica et Biophysica Acta 1760
  
  Pages: 1274-1280
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591946
[Journal Article] Comparison of agonist-induced Ca^<2+> responses in rat submandibular acini and ducts2005
- Author(s)
  A.Nezu, T.Morita, A.Tanimura, Y.Tojyo
- Journal Title
  
  Archives of Oral Biology 50
  
  Pages: 585-592
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591975
[Journal Article] Comparison of agonist-induced Ca^<2+> responses in rat submandibular acini and ducts.2005
- Author(s)
  Nezu A, Morita T, Tanimura A, Tojyo Y
- Journal Title
  
  Archs Oral Biol 56
  
  Pages: 586-592
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591975
[Journal Article] Calcium signaling and salivary secretory function.2005
- Author(s)
  Tojyo, Y.
- Journal Title
  
  Dental Journal of Health Sciences University of Hokkaido 24 (1)
  
  Pages: 1-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591946
[Journal Article] Comparison of agonist-induced Ca2+ responses in rat submandibular acini and ducts.2005
- Author(s)
  A.Nezu, T.Morita, A., Tanimura, Y.Tojyo
- Journal Title
  
  Archives of Oral Biology (in press)
- Data Source
  KAKENHI-PROJECT-15591975
[Journal Article] カルシウムシグナルと唾液分泌機能2005
- Author(s)
  東城庸介
- Journal Title
  
  北海道医療大学歯学会雑誌 24 (1)
  
  Pages: 1-11
- NAID
  120005454892
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591946
[Journal Article] Fluorescent Biosensor for quantitative real-time measurements of inositol 1,4,5-trisphosphate in single living cells2004
- Author(s)
  A.Tanimura, A, Nezu, T, Morita, R., J.Turner, Y.Tojyo
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 38095-38098
- Data Source
  KAKENHI-PROJECT-16390532
[Presentation] Intravitalイメージングを用いた顎下腺のCa2+応答と唾液分泌のリアルタイムモニタリング2014
- Author(s)
  根津顕弘、森田貴雄、東城庸介、永井健治、谷村明彦
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] 生きた動物における学会線Ca2+応答のリアルタイムイメージングと唾液分泌の同時測定2014
- Author(s)
  根津顕弘、森田貴雄、東城庸介、谷村明彦
- Organizer
  第２８回唾液腺談話会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] スタウロスポリンはCa2+ストアの再充填後もストア作動性Ca2+流入を持続させる2014
- Author(s)
  東城庸介、森田貴雄、根津顕弘、谷村明彦
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] 生きた動物における薬物および神経刺激による顎下腺のCa2+応答、唾液分泌および血流量の同時測定2014
- Author(s)
  根津顕弘、森田貴雄、東城庸介、永井健治、谷村明彦
- Organizer
  第５９回　唾液腺学会
- Place of Presentation
  東京文京大学（東京都文京区）
- Year and Date
  2014-12-06
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] アデノウイルスのin vivo遺伝子導入法を用いたラット顎下腺腺房細胞へのStim1-mKO1発現によるCa2+応答の増大および唾液分泌への影響2014
- Author(s)
  森田貴雄、根津顕弘、東城庸介、谷村明彦
- Organizer
  第５９回　唾液腺学会
- Place of Presentation
  東京文京大学（東京都文京区）
- Year and Date
  2014-12-06
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] ウイルスベクターを用いた発光および蛍光プローブの唾液腺細胞への導入と機能解析2013
- Author(s)
  森田貴雄、根津顕弘、東城庸介、谷村明彦
- Organizer
  第55回歯科基礎医学会学術大会
- Place of Presentation
  岡山市
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] In vivo実験系を用いたピロカルピンによる唾液腺細胞のCa2+応答と唾液分泌機構の解析2013
- Author(s)
  根津顕弘、森田貴雄、東城庸介、永井健治、谷村明彦
- Organizer
  第64回日本薬理学会北部会
- Place of Presentation
  旭川市
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] 唾液腺のCa2+応答と唾液分泌に対するピロカルピンの作用2013
- Author(s)
  根津顕弘、森田貴雄、東城庸介、谷村明彦
- Organizer
  第８６回日本薬理学会年会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] ラット顎下腺細胞のCa2+応答と唾液分泌に対するピロカルピンの部分作動薬作用2013
- Author(s)
  谷村明彦、根津顕弘、森田貴雄、東城庸介
- Organizer
  第33回日本歯科薬物療法学会
- Place of Presentation
  東京都文京区
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] Intravital イメージングを用いた顎下腺のCa2+応答と唾液分泌の同時解析2013
- Author(s)
  根津顕弘、森田貴雄、東城庸介、永井健治、谷村明彦
- Organizer
  第58回日本唾液腺学会
- Place of Presentation
  東京都文京区
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] アデノウイルスの導入によりin vivoで発現させたStim1によるCa^<2+>応答と唾液分泌の増強2012
- Author(s)
  森田貴雄、根津顕弘、東城庸介、谷村明彦
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-22592073
[Presentation] 唾液腺のCa2+応答と唾液分泌に対するムスカリン受容体部分作動薬としてのピロカルピンの作用2012
- Author(s)
  根津顕弘、森田貴雄、東城庸介、谷村明彦
- Organizer
  第５７回日本唾液腺学会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] 細胞質発現型IP_3バイオセンサーの唾液腺腺房細胞への導入とIP_3動態の測定2012
- Author(s)
  根津顕弘、森田貴雄、東城庸介、谷村明彦
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-22592073
[Presentation] ラット顎下腺腺房細胞へのStim1-mKO1発現によるCa2+ストアおよびCa2+放出量の増大2012
- Author(s)
  森田貴雄、根津顕弘、東城庸介、谷村明彦
- Organizer
  第５４回歯科基礎医学会
- Place of Presentation
  郡山市
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] 唾液腺のCa2+応答と唾液分泌に対するムスカリン受容体パーシャルアゴニストとしてのピロカルピンの作用2012
- Author(s)
  根津顕弘、森田貴雄、東城庸介、谷村明彦
- Organizer
  第５４回歯科基礎医学会
- Place of Presentation
  郡山市
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] IP_3バイオセンサーのラット唾液腺腺房細胞への導入とIP_3動態の観察2011
- Author(s)
  根津顕弘、森田貴雄、東城庸介、谷村明彦
- Organizer
  第53回歯科基礎医学会学術大会
- Place of Presentation
  岐阜市
- Year and Date
  2011-10-02
- Data Source
  KAKENHI-PROJECT-22592073
[Presentation] ラット顎下腺へのアデノウイルスのin vivo注入によるStim-1-mKO1の発現2011
- Author(s)
  東城庸介
- Organizer
  第31回日本歯科薬物療法学会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] 細胞質発現型IP3バイオセンサーの分離精製と耳下腺腺房細胞への導入2011
- Author(s)
  根津顕弘、森田貴雄、谷村明彦、東城庸介
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  東日本大震災による誌上開催
- Data Source
  KAKENHI-PROJECT-20592180
[Presentation] 唾液腺への非侵襲的アデノウイルス注入によるStimlのin vivo発現と機能解析2010
- Author(s)
  森田貴雄、谷村明彦、設楽彰子、鈴木裕子、根津顕弘、田隈泰信、東城庸介
- Organizer
  第61回日本薬理学会北部会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-20592180
[Presentation] 唾液腺腺房細胞に発現させたStim1-mKO1によるCa2+応答の増強2010
- Author(s)
  森田貴雄、谷村明彦、設楽彰子、根津顕弘、田隈泰信、東城庸介
- Organizer
  第52回歯科基礎医学会学術大会
- Place of Presentation
  タワーホール船堀(東京都)
- Data Source
  KAKENHI-PROJECT-20592180
[Presentation] 唾液腺への非侵襲的アデノウイルス注入によるStim1のin vivo発現と機能解析2010
- Author(s)
  森田貴雄、谷村明彦、設楽彰子、鈴木裕子、根津顕弘、田隈泰信、東城庸介
- Organizer
  第61回日本薬理学会北部会
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-20592180
[Presentation] 細胞質発現型IP_3バイオセンサーの精製とそれを用いた耳下腺腺房細胞のIP_3濃度測定への応用2009
- Author(s)
  根津顕弘、谷村明彦、森田貴雄、東城庸介
- Organizer
  第51回歯科基礎医学会学術大会
- Place of Presentation
  新潟市
- Data Source
  KAKENHI-PROJECT-20592180
[Presentation] 唾液腺へのアデノウイルス注入による蛍光標識分子の生体内発現と細胞内局在の解析2009
- Author(s)
  森田貴雄、谷村明彦、設楽彰子、根津顕弘、田隈泰信、東城庸介
- Organizer
  第51回歯科基礎医学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟県)
- Data Source
  KAKENHI-PROJECT-20592180
[Presentation] Monitoring of IP_3 dynamics during Ca^<2+> oscillations in HSY human parotid cell line with FRET-based IP_3 biosensors2009
- Author(s)
  Tanimura A, Morita T, Nezu A, Tojyo Y.
- Organizer
  The 11^<th> international Symposium on Exocrine Secretion
- Place of Presentation
  徳島市
- Data Source
  KAKENHI-PROJECT-20592180
[Presentation] Spontaneous Ca^<2+> oscillations via purinergic receptors elicit transient cell shrinkage in rat parotid ducts.2009
- Author(s)
  Shitara A, Tanimura A, Sato A, Tojyo Y.
- Organizer
  The 11^<th> International Symposium of Exocrine Secretion
- Place of Presentation
  徳島大学、長井記念ホール(徳島県)
- Data Source
  KAKENHI-PROJECT-20592180
[Presentation] 細胞質発現型IP3バイオセンサーの精製と耳下腺腺房細胞のIP3濃度測定への応用2009
- Author(s)
  根津顕弘、森田貴雄、谷村明彦、東城庸介
- Organizer
  第51回歯科基礎医学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟県)
- Data Source
  KAKENHI-PROJECT-20592180
[Presentation] ラット耳下腺導管細胞における自発的Ca^<2+>反応の発生機構2008
- Author(s)
  設楽彰子、谷村明彦、森田貴雄、根津顕弘、東城庸介
- Organizer
  第50回歯科基礎医学会学術大会
- Place of Presentation
  東京都(品川)
- Data Source
  KAKENHI-PROJECT-20592180
[Presentation] アデノ随伴ウイルス（AAV）ベクターを用いたCa2+バイオセンサーの長期発現と唾液腺細胞の長時間Ca2+イメージング
- Author(s)
  森田貴雄、根津顕弘、東城庸介、谷村明彦
- Organizer
  第５６回歯科基礎医学会学術大会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] 生きた動物の唾液腺におけるアセチルコリンによる組織全体で同期するCa2+振動
- Author(s)
  根津顕弘、森田貴雄、東城庸介、永井健治、谷村明彦
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] Intravital Ca2+イメージングによる唾液分泌制御機構の解析
- Author(s)
  谷村明彦、根津顕弘、森田貴雄、東城庸介、佐藤寿哉、石井久淑
- Organizer
  平成26年度生理学研究所研究会「唾液腺形成研究会～機能解析から器官再生へ～」
- Place of Presentation
  生理学研究所（愛知県岡崎市）
- Year and Date
  2014-08-04 – 2014-08-05
- Invited
- Data Source
  KAKENHI-PROJECT-23390425
[Presentation] 唾液分泌刺激薬による顎下腺のCa2+応答のintravitalイメージングと唾液分泌の同時測定
- Author(s)
  根津顕弘、森田貴雄、東城庸介、谷村明彦
- Organizer
  第５６回歯科基礎医学会学術大会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-23390425

1. TANIMURA Akihiko (70217149)

# of Collaborated Projects: 12 results

# of Collaborated Products: 55 results
2. MORITA Takao (20326549)

# of Collaborated Projects: 8 results

# of Collaborated Products: 48 results
3. NEZU Akihiro (00305913)

# of Collaborated Projects: 8 results

# of Collaborated Products: 44 results
4. MATSUI Satoko (30190391)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. ARAKAWA Toshiya (40306254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKUMA Taishin (40095336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OKUMURA Kazuhiko (60194510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 和泉博之 (20108541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 東城庸介 (90111749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TOJYO Yosuke 東城 庸介

Research Projects

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Co-Researchers

Intravital imaging study for the regulation of salivary gland functions

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Analysis of spatiotemporal pattern in IP^ production in submandibulargland using fluorescent-biosenseorPrincipal Investigator

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Imaging analysis of the electrolyte transport and protein secretions in salivary ducts to reveal their regulatory mechanisms

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Visualization of spatio-temporal pattern of IP3/Ca2+ signaling in salivary glandsPrincipal Investigator

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STUDIES ON THE DYNAMICS OF PHOSPHOINOSITIDE PATHWAYS AND THE DEVELOPMENT OF FLUORESCENT BIOSENSORS

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Real-time monitoring of cellular signaling in salivary secretion by multiphoton excitation imagingPrincipal Investigator

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蛍光共鳴エネルギー転移を応用したイノシトール三リン酸の細胞内動態のイメージングPrincipal Investigator

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Imaging of the signal molecules mediating secretory responses in salivary gland cellsPrincipal Investigator

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Imaging of chnages in intracellular ion distribution induced by receptor stimulation in parotid aciner cellsPrincipal Investigator

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Molecular mechanism of the receptor-mediated Ca^<2+> entry in parotid cellsPrincipal Investigator

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The cross-talk and secretion in intracellular signaling in parotid glandsPrincipal Investigator

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The physiological role and the control mechanism of Ca^<2+>-mobilization in stimulation-secretion coupling in parotid glandPrincipal Investigator

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The Physiological Role of Calmodulin in Rat Parotid Amylase ReleasePrincipal Investigator

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TOJYO Yosuke 東城庸介