TOJO Hiromasa 東城博雅

Researcher Number	90135707
External Links
Affiliation (based on the past Project Information) *help	2007 – 2008: Osaka University, 生命機能研究科, 准教授 2004 – 2005: 大阪大学, 生命機能研究科, 助教授 2004: 大阪大学, 医学系研究科, 助教授 2002: GRADUATE SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 助教授 2002: 大阪大学, 医学研究科, 助教授 … More 1999 – 2001: 大阪大学, 医学系研究科, 助教授 1996 – 1998: 大阪大学, 医学部, 助教授 1994: 大阪大学, 医学部, 助教授 1993: Osaka University Medical School, Department of Molecular Physiological Chemistry, Lecturer, 大阪大学医学部, 講師 1992 – 1993: 大阪大学, 医学部, 講師 1986 – 1990: 大阪大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / General medical chemistry / Pathological medical chemistry / 代謝生物化学 / 物質生物化学 / Biological Sciences Except Principal Investigator General physiology / Dermatology / Dermatology / Kidney internal medicine
Keywords	Principal Investigator リン脂質 / phospholipids / ホスホリパーゼB / リパーゼ / HPLC / ホスホリパーゼA2 / phospholipase B / リピドミクス / リゾホスファチジン酸 / 精巣 … More / リゾビスホスファチジン酸 / ホスファチジン酸 / 質量分析 / mass spectrometry / sphingolipids / lipidomics / エレクトロスプレー / 順相クロマトグラフィー / 脂質 / リピドミックス / スフィンゴ脂質 / lysophosphatidic acid / testis / monoacylglycerollipase / lysobisphosphatidic acid / phosphatidic acid / phospholipase A2 / モノアシルグリセロールリパーゼ / site-directed mutagenesis / lipase / phospholipase A / 部位特異変異法 / 部位特異変位法 / ホスホリパーゼA / bovine aorta / phospholipase A_2 / 牛大動脈中膜 / 血管平滑筋 / ウシ大動脈 / ホスホリパーゼA_2 / Phospholipid Metabolism / parietal Cell / Chief Cell / Group II Phospholipase A2 / Pancreatic phospholipase / 胃酸分泌 / 消化管 / リン脂質代謝 / 壁細胞 / 主細胞 / II群ホスホリパ-ゼA_2 / 膵臓型ホスホリパ-ゼA_2 / 分化 / 消化吸収 / 小腸 … More Except Principal Investigator Arnt / スフィンゴ脂質 / コンディショナルジーンターゲティング / Stat3 / loxP / Cre / amino acid oxidase / flavin / ラマンスペクトル / アミノ酸 / 酸化還元酵素 / 分子集合形成機構 / アミン酸酸化酵素 / ビタミン【B_2】 / フラビン蛋白 / 共鳴ラマン分光 / セミキノン / フラビン酵素 / 分子間相互作用 / アミノ酸酸化酵素 / フラビン / mouse / barrier function / conditional gene targeting / SPT / epidermis / sphingolipid / desaturase / 遺伝子破壊 / バリヤー機能 / スフィンゴ脂質合成酵素 / マウス / 表皮 / 組織特異的遺伝子破壊 / Pten / Bcl-xL / Conditional gen targeting / Tリンパ球 / LCB2遺伝 / ARNT遺伝子 / トランスジェニックマウス / キメラマウス / Anrt遺伝子 / ラットThy1腎炎 / mitogen-activated protein(MAP)キナーゼ / 血小板由来増殖因子 / メザンギウム細胞 / 慢性糸球体腎炎 / インターロイキン1 / II群ホスホリパーゼA_2 Less

Lipidomic analysis of the action of Phospholipase B/Lipase on intestinal mucosal cell differentiationPrincipal Investigator
- Principal Investigator
  
  TOJO Hiromasa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
Development of a fully automated lipid analyzer aimed at lipid metabolomics and disease analysisPrincipal Investigator
- Principal Investigator
  
  TOJO Hiromasa
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
Physiological roles of epidermal sphingolipids with conditional gene targeting.
- Principal Investigator
  
  TAKEDA Junji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Osaka University
表皮維持機構を解析するための新しい手法による遺伝子改変マウス作製
- Principal Investigator
  
  TAKEDA Junji
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  OSAKA UNIVERSITY
Catalytic mechanism and function of phosphatidate-specific phospholipases A2Principal Investigator
- Principal Investigator
  
  TOJO Hiromasa
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
ホスホリパーゼA2ファミリーのメンバーの新しい機能Principal Investigator
- Principal Investigator
  
  東城博雅
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (B)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Properties of Ca2+-independent phospholipase A2 and its roles in phospholipid fatty acid remodelingPrincipal Investigator
- Principal Investigator
  
  TOJO Hiromasa
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
情報伝達因子としての分泌型ホスホリパーゼA_2の糸球体腎炎における役割
- Principal Investigator
  
  和田晃
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Osaka University
Enzymatic properties of a phospholipase A_2 from vascular smooth muscles and its physiological significancePrincipal Investigator
- Principal Investigator
  
  TOJO Hiromasa
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  Osaka University
A Role of Pancreatic-type Phospholipase A2 in Gastric Acid SecretionPrincipal Investigator
- Principal Investigator
  
  TOJO Hiromasa
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Osaka University Medical School
A physico-chemical study on the interaction between amino acid oxidase and ligands
- Principal Investigator
  
  SHIGA Kiyoshi
- Project Period (FY)
  1985 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  General physiology
- Research Institution
  Kumamoto University

All 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] 自動化脂質分析装置を用いた病態リピドミクス"メタポロミクスの先端技術と応用"第20章2008
- Author(s)
  東城博雅
- Publisher
  シーエスシー出版
- Data Source
  KAKENHI-PROJECT-19590307
[Book] 質量分析学2008
- Author(s)
  東城博雅
- Publisher
  大阪大学出版会(印刷中)
- Data Source
  KAKENHI-PROJECT-19590307
[Book] メタボロミクスの先端技術と応用2008
- Author(s)
  東城博雅
- Publisher
  シーエスシー出版
- Data Source
  KAKENHI-PROJECT-19590307
[Book] リピドミクス質量分析学9章
- Author(s)
  東城博雅
- Publisher
  大阪大学出版会(印刷中)
- Data Source
  KAKENHI-PROJECT-19590307
[Journal Article] Cbesity causes a shift in metabolic flow of gangliosides in adipose tissues2009
- Author(s)
  Tanabe, A., Mgt suds, M, Fukuhara, A., Myata, Y., Komuro, R, Shimomura, I., Tojo, H.
- Journal Title
  
  Biochem Biophy.Res.Commun 379
  
  Pages: 547-552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590307
[Journal Article] Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SNS1)-knockdown T cells2008
- Author(s)
  Jin, ZX, Huang, CR, Dong, L., Goda, S., Kawanami T., Sawaki T., Sakai T., Tong XP., Masaki Y., Fukushima T., Tanaka M, Mimori T., Tojo, H., Bloom ET., Ckazaki T., Umehara, H.
- Journal Title
  
  Int.Immunol 20
  
  Pages: 1427-1437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590307
[Journal Article] 2-Hydroxy- ceramide synthesis by ceramide synthase family : enzymatic basis for the preference of FA chain length.2008
- Author(s)
  Mizutani, Y., Kihara, A., Chiba, H., Tojo, H., Igarashi, Y.
- Journal Title
  
  J.Lipid Res. 49
  
  Pages: 2356-2364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590307
[Journal Article] Molecular Characterization of Menbrane-Associated Soluble Serine Palnitoyltransferases from Sphingobacterium multivorun, Sphingobacterium spiritivorun and Bdellovibriostolpii2007
- Author(s)
  Ikushiro, H., Islam, M., Tojo, H., Hayashi, H.
- Journal Title
  
  J.Bactriol 189
  
  Pages: 5749-5761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590307
[Journal Article] Analysis and determination of novel glycolipids in vertebrate brains by HPLC/mass spectreometry.2006
- Author(s)
  Nagatsuka, Y., Tojo, H., Hirabayashi, Y.
- Journal Title
  
  Methods Enzymol (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390093
[Journal Article] Three-Dimensional Structure of Rat-Liver Acyl-CoA Oxidase in Complex with a Fatty Acid : Insights into Substrate-Recognition and Reactivity toward Molecular Oxygen2006
- Author(s)
  Tokuoka, K., Nakajima, Y., Hirotsu, K., Miyahara, I., Nishina Y., Shiga, K., Tamaoki, H., Setoyama, C., Tojo, H., Miura, R.
- Journal Title
  
  J.Biochem. 139
  
  Pages: 789-795
- NAID
  10018845985
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390093
[Journal Article] The Angiotensin-converting Enzyme (ACE) is a GPI-anchored Protein Releasing Factor Crucial for Fertilization.2005
- Author(s)
  Kondo, G., Tojo, H., Nakatani, Y., Komazawa, N., Murata, C., Yamagata, K., Maeda, Y., Kinoshita, T., Okabe, M., Taguchi, R., Takeda, J.
- Journal Title
  
  Nature Med. 11
  
  Pages: 160-166
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390093
[Journal Article] Phospholipase A2 belonging to lipase families.2005
- Author(s)
  Tojo, H.
- Journal Title
  
  KASEAA 43
  
  Pages: 516-518
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390093
[Journal Article] A cytosolic cytochrome b5-like protein in yeast cell accelerating the electron transfer from NADPH to cytochrome c catalyzed by Old Yellow Enzyme.2005
- Author(s)
  Nakagawa, M., Yamano, T., Kuroda, K., Nonaka, Y., Tojo, H., Fujii, S.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 338
  
  Pages: 605-609
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390093
[Journal Article] リパーゼファミリーに属するホスホリパーゼA2 触媒トライアッドの不思議2005
- Author(s)
  東城博雅
- Journal Title
  
  化学と生物 43
  
  Pages: 516-518
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390093
[Journal Article] リパーゼファミリーに属するホスホリパーゼA2 触媒トライアッドの不思議2005
- Author(s)
  東城博雅
- Journal Title
  
  化学と生物 43
  
  Pages: 516-518
- Data Source
  KAKENHI-PROJECT-16390093
[Journal Article] Recent developments in mass spectrometry-based lipid metabolomics2004
- Author(s)
  Tojo, H.
- Journal Title
  
  Oleoscience 4
  
  Pages: 147-156
- NAID
  10012704729
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390093
[Journal Article] Fully automated online multi-dimensional protein profiling system complex mixtures2004
- Author(s)
  Fujii, K., Nakano, T., Hike, H., Usui, F., Bando, Y., Tojo, H., Nishimura, T.
- Journal Title
  
  J.Chromatogr. A1057
  
  Pages: 107-113
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390093
[Journal Article] Properties of an electrospray emitter coated with material of low surface energy.2004
- Author(s)
  Tojo, H.
- Journal Title
  
  J.Chromatogr. A1056
  
  Pages: 223-228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390093
[Journal Article] Properties of an electrospray emitter coated with material of low surface energy2004
- Author(s)
  Tojo, H
- Journal Title
  
  J.Chromatogr.A 1056
  
  Pages: 223-228
- Data Source
  KAKENHI-PROJECT-16390093
[Journal Article] 質量分析を利用した脂質メタボロミックスの現況2004
- Author(s)
  東城博雅
- Journal Title
  
  オレオサイエンス 4
  
  Pages: 3-12
- NAID
  10012704729
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390093
[Journal Article] Properties of an electrospray emitter coated with material of low surface energy.2004
- Author(s)
  Tojo, H.
- Journal Title
  
  J.Chromatogr.A 1056
  
  Pages: 223-228
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390093
[Presentation] Lipidomics shows that obesity causes a shiftin steady-state metabolic flow of gangliosides downstream from GMB in adipose tissues of murine genetic and nutritional disease models2009
- Author(s)
  Tojo, H., Tanabe, A.
- Organizer
  2009 ASMS Sanibel conference
- Place of Presentation
  フロリダ米国
- Year and Date
  2009-01-24
- Data Source
  KAKENHI-PROJECT-19590307
[Presentation] Abeneficial effect of polyphenol oligomers, oligonol, on choline deficiency induced fatty liver in nice2008
- Author(s)
  Tojo, H. Igura, T., Nbnomura, S., Sumi, R., Bando, Y., Ito. T.
- Organizer
  49th International Conference on the Bioscience of Lipids
- Place of Presentation
  マーストリヒト、オランダ
- Year and Date
  2008-08-29
- Data Source
  KAKENHI-PROJECT-19590307
[Presentation] 肥満脂肪組織におけるスフィンゴ糖脂質代謝の変化-HPLC/質量分析による解析2008
- Author(s)
  田邉文, 福原淳範, 下村伊一郎, 東城博雅
- Organizer
  BMB 2008
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19590307
[Presentation] A Beneficial Effect of Polyphenol Oligomers, Oligonol, on Choline deficiency-induced Fatty Liver in mice.2008
- Author(s)
  Hiromasa Tojo
- Organizer
  49th International Conference on the Bioscience of Lipids
- Place of Presentation
  Maastricht University Netherlands
- Year and Date
  2008-08-29
- Data Source
  KAKENHI-PROJECT-19590307
[Presentation] 遺伝子変異マウスを用いたボスホリパーゼB/リパーゼの生理的機能の解析2008
- Author(s)
  竹村浩昌, 東城博雅, 近藤玄
- Organizer
  BMB 2008
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19590307
[Presentation] Sphingolipidomic Profiling of the Stratum Corneum of Mice with Keratinocyte-specific Deletion of Aryl Hydrocarbon Receptor Nuclear Translocator Gene2008
- Author(s)
  Tojo, H.
- Organizer
  56th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics
- Place of Presentation
  デンバー米国
- Year and Date
  2008-06-04
- Data Source
  KAKENHI-PROJECT-19590307
[Presentation] Lipidomic analysis based on normal-phase HPLC/mass spectrometry2007
- Author(s)
  Tojo, H
- Organizer
  5th Euro Fed Lipid Congress
- Place of Presentation
  ヨーテボリ、スエーデン
- Year and Date
  2007-09-17
- Data Source
  KAKENHI-PROJECT-19590307
[Presentation] Lipidomic analysis based on normal-phase HPLC/mass spectrometry2007
- Author(s)
  Tojo, H.
- Organizer
  5th Euro Fed Lipid Congress
- Place of Presentation
  ヨーテポリ、スエーデン
- Year and Date
  2007-09-17
- Data Source
  KAKENHI-PROJECT-19590307
[Presentation] 遺伝子変異マウスを用いたボスホリパーゼB/リパーゼの生理的機能の解析2007
- Author(s)
  竹村浩昌, 東城博雅, 近藤玄
- Organizer
  第80会日本生化学大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19590307
[Presentation] Profiling of stratum corneum lipids by an HPLC/mass spectrometry-based automated lipid analyzer2007
- Author(s)
  Tojo, H
- Organizer
  48th International Conference on the Bioscience of Lipids
- Place of Presentation
  ツルク、フィンランド
- Year and Date
  2007-09-07
- Data Source
  KAKENHI-PROJECT-19590307
[Presentation] 48th International Conference on the Bioscience of Lipids Profiling of stratumcorneumlipids by an HPLC/mass spectrometry-based automatedlipidanalyzer2007
- Author(s)
  Tojo, H.
- Place of Presentation
  ツルク、ブインランド
- Year and Date
  2007-09-07
- Data Source
  KAKENHI-PROJECT-19590307

1. TAKEDA Junji (50163407)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. KONDOH Gen (40243258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. HASHIMOTO Koji (00110784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SHIGA Kiyoshi (40028527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. WAKITA Yoshiakira (80040179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NISHINA Yasuzo (50112553)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 和田晃 (50252648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 佐藤恭介 (80205905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKEMURA Hiromasa

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. INOUE Shintaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山内淳

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 井上伸太郎

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 坂東泰彦

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TOJO Hiromasa 東城 博雅

Research Projects

Research Products

Co-Researchers

Lipidomic analysis of the action of Phospholipase B/Lipase on intestinal mucosal cell differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a fully automated lipid analyzer aimed at lipid metabolomics and disease analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Physiological roles of epidermal sphingolipids with conditional gene targeting.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

表皮維持機構を解析するための新しい手法による遺伝子改変マウス作製

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Catalytic mechanism and function of phosphatidate-specific phospholipases A2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ホスホリパーゼA2ファミリーのメンバーの新しい機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Properties of Ca2+-independent phospholipase A2 and its roles in phospholipid fatty acid remodelingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

情報伝達因子としての分泌型ホスホリパーゼA_2の糸球体腎炎における役割

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Enzymatic properties of a phospholipase A_2 from vascular smooth muscles and its physiological significancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Role of Pancreatic-type Phospholipase A2 in Gastric Acid SecretionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A physico-chemical study on the interaction between amino acid oxidase and ligands

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 自動化脂質分析装置を用いた病態リピドミクス"メタポロミクスの先端技術と応用"第20章2008

Author(s)

Publisher

Data Source

[Book] 質量分析学2008

Author(s)

Publisher

Data Source

[Book] メタボロミクスの先端技術と応用2008

Author(s)

TOJO Hiromasa 東城博雅