YOSHIZAKI KAZUYUKI 吉崎和幸

… Alternative Names

吉崎和幸ヨシザキカズユキ

Yoshizaki Kazuyuki 吉崎和幸

YOSHIZAKI Kazuyuki 吉崎和幸

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Researcher Number	90144485
Other IDs
External Links
Affiliation (Current)	2025: 大阪大学, 産業科学研究所, 特任教授 2025: 公益財団法人ルイ・パストゥール医学研究センター, その他部局等, 研究員(移行)
Affiliation (based on the past Project Information) *help	2021 – 2022: 大阪大学, 産業科学研究所, 特任教授 2020: 大阪大学, 産業科学研究所, 招へい教授 2015 – 2017: 大阪大学, 産業科学研究所, 特任教授 2009 – 2010: Osaka University, 先端科学イノベーションセンター, 客員教授 1996 – 2004: 大阪大学, 健康体育部, 教授 … More 2003: 大阪大学, 健康体育学部, 教授 2001: 大阪大学, 健康保健体育部, 教授 1994 – 1995: 大阪大学, 健康体育部, 助教授 1993: 大阪大学, 医学部, 講師 1990 – 1993: 大阪大学, 医学部, 助手 1986 – 1988: 大阪大学, 医学部, 助手 1986: 阪大, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Immunology / Collagenous pathology/Allergology / 膠原病・アレルギー・感染症内科学 / Hematology / Immunology / Biological Sciences / 内科学一般 / 免疫の制御機構 / Gastroenterology Except Principal Investigator 内科学一般 … More / Gastroenterology / Basic Section 58020:Hygiene and public health-related: including laboratory approach / Hematology / Living organism molecular science / 広領域 / Immunology / Kidney internal medicine Less
Keywords	Principal Investigator IL-6 / STAT3 / SSI-1 / 多発性骨髄腫 / Castleman's disease / Serum amyloid A(SAA) / AA amyloidosis / Chronic inflammatory disease / NF-κB / EBPβ … More / C / Anti-IL-6R antibody / STAT1 / MAPK / B細胞分化因子 / 免疫学 / 血清アミロイドA / ネガティブフィードバック / 抗bcl-2抗体 / bcl-2 / リンパ球増殖性疾患 / TNF-α / Interleukin6 / B細胞分化機構 / インフリキマム / トシリズマブ / 関節リウマチ / 治療効果予測 / バイオマーカー / Interleukin 6(IL-6) / 転写活性 / IL-1 / RA / ルシフェラーゼプロモーター活性 / DNA affinity chromatography / EMSA / NF-κB p65 / Interleukin 6 (IL-6) / Serum amyloid A (SAA) / negative feedback / multiple myeloma / インターロイキン6 / STAT / 病態解析 / 高γグロブリン血症 / サイトカイン産生異常症 / 遺伝子解析 / IL-1α / BSF-2 / リンフォカイン / B細胞由来 / 発現制御 / 生理活性 / 生体機能利用 / サイトカイン / バイオテクノロジー / 分子間結合伝達 / 多様性機能 / 分子構造 / IL-6阻害 / ペプチド阻害剤 / 小分子ヒト抗体 / single chain fragment variant / ファージライブラリー / 癌増殖抑制 / KSHV / HHV8 / AAアミロイドーシス / VEGF / 血管新生 / ヒト型化抗IL-6受容体抗体療法 / キャッスルマン病 / STAT-3 / STAT-1 / ミエローマ / 慢性関節リウマチ / Castleman病 / IL-6のシグナル伝達阻害 / ヒト型化抗IL-6受容体抗体 / チロシンリン酸化 / シグナル伝達分子 / 増殖分化 / シグナル伝達機構 / インターリウキン6 / SSCP / SCIDマウス / T細胞レパトア / クローン病 / 炎症性腸疾患 / IL-6トランスジェニックSCIDマウス / ヒト型化抗体 / IL-6シグナル伝達 / 抗IL-6レセプター抗体 / Interleukin6(IL-6) / ミエローマ細胞 / Europium / Fluoro immunoassay / IL-5 / IL-8 / TNFα / interleuken 6 receptor / cytokines / immunoassay / DELFIA / 濾胞性リンフォ-マ / 前癌状態 / bclー2 遺伝子 / interleukin6(ILー6) / Castleman′s disease / B細胞増殖性疾患 … More Except Principal Investigator IL-6 / 関節リウマチ / SSI-1 / サイトカイン / トシリズマブ / リウマチ / SOCS-1 / FRP / TNFα / インターロイキン6(IL-6) / 慢性関節リウマチ / インターロイキン6 / T細胞レパトア / クローン病 / 炎症性腸疾患 / 疾患分類 / 血中サイトカイン / Multi-plex / 炎症性ケモカイン / 多中心性キャッスルマン病 / PLS解析 / TCZ:トシリズマブ / COVID-19 / キャッスルマン病 / PLS2解析 / ケモカイン / BMP / tocilizumab / TNFa / TNF-a / フェロポルチン / ヘプシジン / 炎症性貧血 / Differentiation / Proliferation / B cells / T cells / Aged / Ageing / Tac抗原 / 免疫ロゼット法 / IL-2レセプター / PMA / イオノマイシン / 分裂能 / T細胞サブセット / 免疫機能の変化 / B細胞分化因子 / ルーマレセプター / 分化 / 分裂増殖 / B細胞 / T細胞 / 老化 / 加齢 / PHAGE LIBRARY / PEPTIDE ANTAGONIST / ANTIBODY ENGINEERING / MOLECULAR TARGETING / ANTIBODY DRUG / HUMAN ANTIBODY / ファージライブラリー / ペプチド / ミミック / 抗体 / ヒト / ScFv / MCP-1 / ファージライブラリ / ペプチドアンタゴニスト / 抗体エンジニアリング / 分子標的医療 / 抗体医薬 / ヒト抗体 / negative regulator / adenoviral vector / vascular endothelial growth factor / humanized anti-IL-6 receptor antibody / interleukin-6 / rheumatoid arthritis / アデノウイルスベクター / 負の調節因子 / アデノウイルス / 血管内皮増殖因子(VEGF) / ヒト化抗IL-6レセプター抗体 / c-fos / anti-type II collagen antibody / MMP1 / TGF-beta / synovial cells / transgenic mouse / folistatin-related protein / ノックアウトマウス / トランスジェニックマウス / 1マウス / DBA / コラーゲン誘導関節炎 / gp130-RAPS / ホリスタチン関連蛋白 / signal transduction / AFM / crvstal structure / IL6 recetor / IL6 / 結晶構造解析 / 複合体 / インターロイキン-6受容体 / インターロイキン-6 / シグナル伝達 / 原子間力顕微鏡 / 結晶構造 / IL-6受容体 / Negative feedback / IL-6 receptor / Humanized Antibody / Interleukin 6 (IL-6) / Cytokine / Rheumatoid Arthritis / 滑膜細胞 / ネガティブフィードバック / 可溶性IL-6レセプター / ヒト型化抗体 / 腫瘍壊死因子(TNFα) / 二次性アミロイドーシス / メタプロテアーゼ / 血管新生 / 滑膜増殖 / ヒト型抗IL-6レセプター抗体 / RA / T細胞分化 / アポトーシス / 胸腺 / JVSマウス / カルニチン / IL-6トランスジェニックマウス / オールトランスレチノイン酸 / メサンギウム増殖性腎炎 / SCIDマウス / 潰瘍性大腸炎 Less

Determination of disease characteristics of Castleman's disease and Rheumatoid arthritis using serum cytokine and chemokine patterns.
- Principal Investigator
  
  Uno Kazuko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Louis Pasteur Center for Medical Research
Detection of biomarkers in pre-treatment serum which predict the clinical remission on the treatment with biologics in rheumatoid arthritis.Principal Investigator
- Principal Investigator
  
  Yoshizaki Kazuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Osaka University
The elucidation and clinical application of the hepcidin-ferroportin regulation mechanism in inflammatory anemia
- Principal Investigator
  
  Nakazawa Soken
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
有機低分子によるインターロイキン6同属分子の機能的重複と多様性機序解明と臨床応用Principal Investigator
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Osaka University
ファージライブラリーを用いたIL-6阻害ヒト抗体および低分子癌抑制分子の開発Principal Investigator
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Study on molecular targeting using phage dispky library
- Principal Investigator
  
  SUGIMURA Kazuhisa
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kagoshima University
The roles of pro-inflammatory cytokines on induction of acute phase proteins in inflammatory diseasesPrincipal Investigator
- Principal Investigator
  
  YOSHIZAKI Kazuyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Osaka University
Research of molecular biology and gene therapy for Rheumatoid arthritis by regulation of IL-6 signal transduction
- Principal Investigator
  
  NISHIMOTO Norihiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Osaka University
Crystal Structural Analysis of IL6/IL6 receptor Complex and Development of Functional Regulation of IL6 with cDNA
- Principal Investigator
  
  TSUKIHARA Tomitake
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  広領域
- Research Institution
  Osaka University
Suppressive autoantibodies in rheumatoid arthritis : construction of gene-modified animals and analysis of their arthrapathy
- Principal Investigator
  
  OZAKI Shoichi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  St.Marianna University School of Medicine
IL-6シグナル制御による慢性関節リウマチの分子・遺伝子治療の研究
- Principal Investigator
  
  西本憲弘
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Osaka University
キャッスルマン病の病因・病態解析とIL-6阻害による治療研究Principal Investigator
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Osaka University
多発性骨髄腫のサイトカインシグナル伝達におけるネガティブフォードバック機構の解析-SSI-1導入による遺伝子治療の試み-Principal Investigator
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
カルニチン輸送担体異常マウス(JVSマウス)における胸腺アポトーシス現象の解析
- Principal Investigator
  
  西本憲弘
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Study for molecular and gene therapy of rheumatoid arthritis by targeting IL-6 signal transduction.
- Principal Investigator
  
  NISHIMOTO Norihiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Osaka University
Signal transduction of IL-6 in myeloma cellsPrincipal Investigator
- Principal Investigator
  
  YOSHIZAKI Kazuyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Hematology
- Research Institution
  Osaka University
レチノイン酸並びに抗IL-6レセプター抗体によるメサンギウム増殖性腎炎の治療
- Principal Investigator
  
  西本憲弘
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Osaka University
IL-6シグナル伝達阻害による新しい治療法の開発Principal Investigator
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  免疫の制御機構
- Research Institution
  Osaka University
多発性骨髄腫細胞におけるIL-6シグナル伝達機構の解析Principal Investigator
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Crohn病腸粘膜T細胞レセプター遺伝子の塩基配列決定とSCIDモデルマウスの作成
- Principal Investigator
  
  中村秀次
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
IL-6シグナル伝達阻害による多発性骨髄腫治療法の開発Principal Investigator
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
SCIDマウスへのT細胞移入によるクローン病モデルの作成Principal Investigator
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
リンパ球増殖性疾患の悪性化におけるIL-6と癌遺伝子変異Principal Investigator
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka University
炎症性腸疾患の腸粘膜におけるT細胞レパトアとサイトカインの解析
- Principal Investigator
  
  伊藤裕章
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
リンパ球増殖性疾患の悪性化におけるIL-6と癌遺伝子変異Principal Investigator
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka University
時間分解蛍光イムノアッセイによる高感度・広測定域サイトカイン測定系の開発Principal Investigator
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
B組胞増殖性疾患におけるILー6の発現とB細胞分化機構の解析Principal Investigator
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
BSFー2/ILー6産生異常症の解析ー特にポリクローナル高γグロブリン血症をきたす疾患の病態解析Principal Investigator
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
B型胞由来B細胞分化誘導因子(B-BCDF)の遺伝子クローニングPrincipal Investigator
- Principal Investigator
  
  吉崎和幸
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Age-related changes of the immune functions;Proliferative and differetiative activities of B and T lymphocytes
- Principal Investigator
  
  KISHIMOTO Susumu
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Osaka University

All 2022 2021 2018 2017 2016 2015 2013 2010 2009 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] リウマチ病セミナーXXI2010
- Author(s)
  吉崎和幸
- Publisher
  株式会社永井書店
- Data Source
  KAKENHI-PROJECT-21659121
[Book] サイトカインハンティング～先頭を駆け抜けた日本人研究者たち～2010
- Author(s)
  吉崎和幸
- Publisher
  京都大学学術出版会
- Data Source
  KAKENHI-PROJECT-21659121
[Book] サイトカイン・ケモカインのすべて第三版改訂新版(笠倉新平、松島綱治編)2004
- Author(s)
  吉崎和幸他
- Total Pages
  25
- Publisher
  日本医学館
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390314
[Book] サイトカイン・ケモカインのすべて第三版改訂新版(笠倉新平, 松島綱治編)2004
- Author(s)
  吉崎和幸他
- Total Pages
  25
- Publisher
  日本医学館
- Data Source
  KAKENHI-PROJECT-15390314
[Journal Article] Anti-nucleocapsid antibodies enhance the production of IL-6 induced by SARS-CoV-2N protein2022
- Author(s)
  Nakayama Emi E.、Kubota-Koketsu Ritsuko、Sasaki Tadahiro、Suzuki Keita、Uno Kazuko、Shimizu Jun、Okamoto Toru、Matsumoto Hisatake、Matsuura Hiroshi、Hashimoto Shoji、Tanaka Toshio、Harada Hiromasa、Tomita Masafumi、Kaneko Mitsunori、Yoshizaki Kazuyuki、Shioda Tatsuo
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41598-022-12252-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10460
[Journal Article] 血中サイトカイン・ケモカインのPLS2解析による、キャッスルマン病と関節リウマチの疾患特性の解析2022
- Author(s)
  宇野賀津子、吉崎和幸、岩橋充啓、原田博雄、金香充範、富田雅史、藤宮仁
- Journal Title
  
  PASKEN J
  
  Volume: 2021 Pages: 29-35
- Data Source
  KAKENHI-PROJECT-20K10460
[Journal Article] Prompt Reduction in CRP, IL-6, IFN-γ, IP-10, and MCP-1 and a Relatively Low Basal Ratio of Ferritin/CRP Is Possibly Associated With the Efficacy of Tocilizumab Monotherapy in Severely to Critically Ill Patients With COVID-192021
- Author(s)
  Hashimoto Shoji, Yoshizaki Kazuyuki, Uno Kazuko, et al
- Journal Title
  
  Frontiers in Medicine
  
  Volume: 8 Pages: 1-16
- DOI
  10.3389/fmed.2021.734838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K10460
[Journal Article] The Role of Interleukin-6 in Castleman Disease. Castleman Disease.2018
- Author(s)
  Yoshizaki K, Murayama S, Ito H, Koga T.
- Journal Title
  
  Hematology/Oncology Clinics of North America.
  
  Volume: 32(1) Issue: 1 Pages: 23-36
- DOI
  10.1016/j.hoc.2017.09.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09524
[Journal Article] RA治療効果予測マーカーの探索（Detection of Prediction markers on the onset for RA therapy）2017
- Author(s)
  吉崎和幸, 宇野賀津子, 岩橋充啓, 山名二郎, 山名征三, 八木克巳
- Journal Title
  
  アレルギーの臨床(The Allergy in Practice)
  
  Volume: 35(5)No.499 Pages: 74-77
- Data Source
  KAKENHI-PROJECT-15K09524
[Journal Article] Tentative diagnostic criteria and disease severity classification for Castleman disease: A report of the research group on Castleman disease in Japan.2017
- Author(s)
  Fujimoto S, Koga T, Kawakami A, Kawabata H, Okamoto S, Mizuki M, Yano S, Ide M, Uno K, Yagi K, Kojima T, Mizutani M, Tokumine Y, Nishimoto N, Fujiwara H, Nakatsuka SI, Shiozawa K, Iwaki N, Masaki Y, Yoshizaki K.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 7 Pages: 1-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09524
[Journal Article] A reference guide for management of Castleman disease2017
- Author(s)
  吉崎和幸, 岡本真一郎,川端浩, 水木満佐央, 川上純, 正木康史, 矢野真吾, 井出眞, 宇野賀津子, 八木克巳, 小島俊行, 水谷実, 徳嶺進洋, 西本憲弘, 藤原寛, 中塚伸一, 塩沢和子, 岩城憲子, 古賀智裕
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 58 Issue: 2 Pages: 97-107
- DOI
  10.11406/rinketsu.58.97
- NAID
  130005450490
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09524
[Journal Article] International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease.2017
- Author(s)
  Fajgenbaum DC, Uldrick TS, Ide M, Yoshizaki K, van Rhee F, et al.
- Journal Title
  
  Blood
  
  Volume: 129(12) Issue: 12 Pages: 1646-1657
- DOI
  10.1182/blood-2016-10-746933
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09524
[Journal Article] Mechanism and Clinical Significance of IL-6 Combined with TNF-α or IL-1 for the Induction of Acute Phase Proteins SAA and CRP in Chronic Inflammatory Diseases2016
- Author(s)
  Soken-Nakazawa J Song and Kazuyuki Yoshizaki
- Journal Title
  
  Journal of Alcoholism & Drug Dependence
  
  Volume: 4 Issue: 3 Pages: 1-4
- DOI
  10.4172/2329-6488.1000239
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09873, KAKENHI-PROJECT-15K09524
[Journal Article] Tocilizumab for treating rheumatoid arthritis: an evaluation of pharmacokinetics/pharmacodynamics and clinical efficacy2015
- Author(s)
  Soken-Nakazawa J Song and Kazuyuki Yoshizaki
- Journal Title
  
  Expert Opin Drug Metab Toxicol.
  
  Volume: 11(2) Issue: 2 Pages: 307-316
- DOI
  10.1517/17425255.2015.992779
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461452
[Journal Article] Pretreatment Prediction of Individual Rheumatoid Arthritis Patients' Response to Anti-Cytokine Therapy Using Serum Cytokine/Chemokine/ Soluble Receptor Biomarkers.2015
- Author(s)
  Uno K, Yoshizaki K, Iwahashi M, Yamana J, Yamana S, Tanigawa M, Yagi K.
- Journal Title
  
  PLoS One
  
  Volume: Jul 15;10(7) Issue: 7 Pages: 1-15
- DOI
  10.1371/journal.pone.0132055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09524, KAKENHI-PROJECT-25460784, KAKENHI-PROJECT-25461452
[Journal Article] Pathogenic role of IL-6 combined with TNF-α or IL-1 in induction of acute phase protein SAA and CRP in chronic inflammatory disease.2010
- Author(s)
  Kazuyuki Yoshizaki
- Journal Title
  
  Proceeding of the 12th International TNF conference. 2009 (In press)
- Data Source
  KAKENHI-PROJECT-21659121
[Journal Article] Therapeutic efficacy of humanized recombinant anti-IL 6-receptor antibody for children with systemic-onset juvenile idiopathic arthritis.2005
- Author(s)
  Yokota S, Miyamae T, Imagawa T, Iwata N, Katakura S, Mori M, Woo P, Nishimoto N, Yoshizaki K, Kishimoto T.
- Journal Title
  
  Arthritis Rheum. 52
  
  Pages: 818-825
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390314
[Journal Article] Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury.2004
- Author(s)
  Okada S, Nakamaura M, Mikami Y, Shimazaki T, Mihara M, Ohsugi Y, Iwamoto Y, Yoshizaki K, Kishimoto T, Okano H.
- Journal Title
  
  J.Neurosci.Res. 76
  
  Pages: 265-276
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390314
[Journal Article] Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody : a multicenter, double-blind placebo-controlled trial.2004
- Author(s)
  Nishimoto N, Yoshizaki K, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Hashimoto J, Azuma J, Kishimoto T.
- Journal Title
  
  Arthritis Rheum. 50
  
  Pages: 1761-1769
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390314
[Journal Article] IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system.2004
- Author(s)
  Hagihara K, Nishikawa T, Isobe T, Song J, Sugamata Y, Yoshizaki K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 314
  
  Pages: 363-369
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390314
[Journal Article] Anti-interleukin-6 receptor antibody inhibits murine AA-amyloidosis.2004
- Author(s)
  Mihara M, Shiina M, Nishimoto N, Yoshizaki K, Kishimoto T, Akamatsu K.
- Journal Title
  
  J.Rheum. 31
  
  Pages: 1132-1138
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390314
[Journal Article] A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease.2004
- Author(s)
  Ito A, Takazoe M, Fukuda Y, Hibi T, Kusugami K, Andoh A, Matsumoto T, Yamamura T, Azuma J, Nishimoto N, Yoshizaki K, Shimoyama T, Kishimoto T.
- Journal Title
  
  Gastroenterology 126
  
  Pages: 989-996
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390314
[Journal Article] Anti-interleukin-6 receptor antibody therapy reduces vascular endotherlial growth factor(VEGF) production in rheumatoid arthritis.2003
- Author(s)
  Nakahara H, Song J, Sugimoto M, Hagihara K, Kishimoto T, Yoshizaki K, Nishimoto N.
- Journal Title
  
  Arthritis Rheum. 48
  
  Pages: 1521-1529
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390314
[Journal Article] Toxicity, pharmacokinetics, and dose finding study of repetitive treatment with humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis : phase I/II clinical study.2003
- Author(s)
  Nishimoto N, Yoshizaki K, Maeda, K, Kuritani T, Deguchi H, Sato B, Imai N, Kakehi T, Takagi N, Suemura M, Kishimoto T.
- Journal Title
  
  J.Rheum. 30
  
  Pages: 1426-1435
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390314
[Presentation] トシリズマブ(TCZ)治療前後の血清サイトカイン・ケモカインを用いたPLS2解析によるCOVID-19, キャッスルマン病(iMCD) および間接リウマチの疾患特性の解析2022
- Author(s)
  宇野賀津子,吉崎和幸, 田中敏郎, 橋本章司, 原田博雅金香充範, 冨田雅史, 中山英美, 塩田達雄 , 藤宮仁
- Organizer
  第50回臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K10460
[Presentation] Characterizing COVID-19, Castleman’s Disease and Rheumatoid Arthritis Based on Patients’ Serum Cytokine and Chemokine Patterns Before and After Tocilizumab Treatment Using Partial Least Squares Regression 2 Analysis2022
- Author(s)
  Uno K, Yoshizaki K, Tanaka T, Hashimoto S, Iwahashi M, Nakayama E, Shiota T, Fujimiya H
- Organizer
  Cytokines 2022
- Data Source
  KAKENHI-PROJECT-20K10460
[Presentation] Comparing COVID-19 and H1N1 Influenza: Analyzing Cytokine and Chemokine Profiles2022
- Author(s)
  Uno K, Yoshizaki K, Tanaka T, Hashimoto S, Harada H, Kaneko M, Tomita M, Nakayama E, Shiota T, Tsuchihashi Y, Fujimiya H
- Organizer
  JSICR/MMCB 2022 Joint Symposium
- Data Source
  KAKENHI-PROJECT-20K10460
[Presentation] Tocilizumab treatment of COVID-19, Castleman’s Disease and Rheumatoid Arthritis: controlling IL-6 improves the pathology of diseases with a variety of etiologies2022
- Author(s)
  Uno K, Yoshizaki K
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K10460
[Presentation] 新型コロナ感染症とH1N1型インフルエンザの血中サイトカイン・ケモカイン動態: PLS2解析法による疾患特性分析の試み2022
- Author(s)
  宇野賀津子,吉崎和幸, 田中敏郎, 橋本章司, 原田博雅金香充範, 冨田雅史, 中山英美, 塩田達雄 , 藤宮仁
- Organizer
  第22回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-20K10460
[Presentation] Characterizing COVID-19, Castleman’s Disease and Rheumatoid Arthritis Based on Patients’ Serum Cytokine/Chemokine Patterns Before and After Tocilizumab Treatment Using Partial Least Squares Regression 2 Analysis2021
- Author(s)
  Kazuko Uno, Toshio Tanaka, Kazuyuki Yoshizaki
- Organizer
  The 50th Annual Meeting of the Japanese Society forImmunology
- Data Source
  KAKENHI-PROJECT-20K10460
[Presentation] Characterizing COVID-19, Castleman’s Disease and Rheumatoid Arthritis Based on Patients’ Serum Cytokine and Chemokine Patterns Before and After Tocilizumab Treatment Using Partial Least Squares Regression 2 Analysis2021
- Author(s)
  K. Uno, H. Fujimiya, M. Iwahashi, S. Hashimoto, T. Tanaka, K. Yoshizaki
- Organizer
  Cytokines 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K10460
[Presentation] Disease Characterization of Castleman’s Disease and Rheumatoid Arthritis based on Serum Cytokine and Chemokine Patterns Using Partial Least Squares Regression 2 Analysis2021
- Author(s)
  Kazuko Uno, Kazuyuki Yoshizaki, Mitsuhiro Iwahashi, Hitoshi Fujimiya
- Organizer
  1st International Symposium on Castleman Disease
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K10460
[Presentation] Changes in Serum Cytokines and Chemokines in Multicentric Castleman Disease after Tocilizumab IL-6 Blocking Therapy2017
- Author(s)
  Kazuyuki Yoshizaki and Kazuko Uno
- Organizer
  ICIS2017 The 5th Annual Meeting of the International Cytokine and Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09524
[Presentation] Soluble Form of GP130 Molecule, An IL-6 Inhibitor, Contributes The Efficacy on RA To Tocilizumab (An Anti-IL-6 Receptor Antibody) Therapy2016
- Author(s)
  K. Yoshizaki, S. N. J. Song, H. Itoh, M. Iwahashi, K. Uno
- Organizer
  EULAR 2016
- Place of Presentation
  London (U.K.)
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09524
[Presentation] 関節リウマチの治療前バイオマーカーによる個別化医療の開発2016
- Author(s)
  吉崎和幸
- Organizer
  日本臨床免疫学会ランチョンセミナー
- Place of Presentation
  京王プラザホテル（東京）
- Year and Date
  2016-09-08
- Invited
- Data Source
  KAKENHI-PROJECT-15K09524
[Presentation] The role of soluble forms of IL-6 receptor (sIL-6R) and soluble form of gp130 (sgp130) on the regulation of IL-6 signaling in rheumatoid arthritis.2016
- Author(s)
  Kazuyuki Yoshizaki
- Organizer
  ICI2016
- Place of Presentation
  Melbourne (Australia)
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09524
[Presentation] Two Soluble Forms of IL-6 Receptor, sIL-6R and sgp130, Regulate Physiological Status and Affect Inflammatory Status Pathologically.2015
- Author(s)
  Kazuyuki Yoshizaki, Soken Nakazawa and Kazuko Uno.
- Organizer
  FOCIS2015
- Place of Presentation
  San Diego, California, USA
- Year and Date
  2015-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] Two soluble forms of IL-6 receptor, sIL-6R and sgp130, regulate physiological status and affect inflammatory status pathologically2015
- Author(s)
  Kazuyuki Yoshizaki
- Organizer
  FOCIS2015
- Place of Presentation
  San Diego, California
- Year and Date
  2015-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09524
[Presentation] Opposite role of Soluble Forms of IL-6 Receptor, SIL-6R and sgp130, on the Regulation of Inflammatory Status in Rheumatoid Arthritis2015
- Author(s)
  Yoshizaki K, Soken-Nakazawa J Song and Uno K
- Organizer
  12th World Congress on Inflammation
- Place of Presentation
  Boston, USA
- Year and Date
  2015-08-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] Different mechanism of anemia in chronic inflammatory disease and improvement of anemia by IL-6 blocking therapy.2013
- Author(s)
  Kazuyuki Yoshizaki and Soken-Nakazawa J Song
- Organizer
  The Federation of Clinical Immunology Societies (FOCIS)
- Place of Presentation
  Boston. USA
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] Analysis of the Molecular Mechanisms Leading to Significantly Higher Serum Hepcidin and More Severe Anemia in Multicentric Castleman’s Disease (MCD) Patients Than in Rheumatoid Arthritis (RA) Patients.2013
- Author(s)
  Soken-Nakazawa J. Song, H Kawabata and K Yoshizaki.
- Organizer
  The American Society of Hematology（ASH）
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] ヘプシジンを介する炎症性貧血のサイトカイン制御機構2013
- Author(s)
  吉崎和幸、中沢宗健
- Organizer
  第3４回日本炎症再生学会
- Place of Presentation
  京都（国際会館）
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] Different role of IL-6 and TNF-α in the immune-pathogenesis of RA, an autoimmune disease2010
- Author(s)
  吉崎和幸
- Organizer
  Federation of Clinical Immunology Society 2010 (FOCIS 2010)
- Place of Presentation
  Boston, USA
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] キャッスルマン病における炎症性貧血に関与するサイトカインの同定2010
- Author(s)
  吉崎和幸
- Organizer
  日本炎症・再生医学会
- Place of Presentation
  東京
- Year and Date
  2010-07-05
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] IFX, ETA, TCZの連続治療に抵抗性を示し、ADA治療中の難治性RAの意義2010
- Author(s)
  吉崎和幸
- Organizer
  第54回日本リウマチ学会
- Place of Presentation
  神戸ポートピアホテル
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] Development and function of an IL-6 blocking antibody, Tocilizumab, as an anti-inflammatory drug2010
- Author(s)
  吉崎和幸
- Organizer
  8th Annual Congress of International Drug Discovery, Science and Technology
- Place of Presentation
  Beijn,China(招待講演)
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] IL-6と免疫疾患:その病態2010
- Author(s)
  吉崎和幸
- Organizer
  東京理科大学セミナー
- Place of Presentation
  東京
- Year and Date
  2010-01-08
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] ～教育講演～「関節リウマチにおけるIL-6」2010
- Author(s)
  吉崎和幸
- Organizer
  第54回日本リウマチ学会
- Place of Presentation
  神戸ポートピアホテル
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] Anti-IL-6receptor Mab (Tocilizumab) in RA : Role of IL-6 blocking therapy on the improvement of RA2010
- Author(s)
  吉崎和幸
- Organizer
  BIT's 2nd International Congress of Antibodies-2010(ICA 2010)
- Place of Presentation
  北京、中国
- Year and Date
  2010-03-25
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] リウマチ診療の最前線とアミロイドーシス臨床研究会2010
- Author(s)
  吉崎和幸
- Organizer
  第1回炎症・免疫イノベーションセミナー
- Place of Presentation
  東京
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] IL-6 plays an essential role in Multi-factors associated hepcidin regulation : anti-IL-6R Ab therapy improved inflammatory anemia in multi-centric Castleman's disease and rheumatoid arthritis (RA) patients2010
- Author(s)
  吉崎和幸
- Organizer
  Federation of Clinical Immunology Society 2010 (FOCIS 2010)
- Place of Presentation
  Boston, USA
- Year and Date
  2010-06-24
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] ～最新治療セミナー2～「トシリズマブ(アクテムラ)」2010
- Author(s)
  吉崎和幸
- Organizer
  第54回日本リウマチ学会
- Place of Presentation
  神戸ポートピアホテル
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] AAアミロイドーシスのトシリズマブによる治療研究4. AAアミロイドーシス臨床研究会による治療継続2010
- Author(s)
  吉崎和幸
- Organizer
  アミロイドーシス班研究報告会
- Place of Presentation
  東京
- Year and Date
  2010-01-29
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] The therapeutic Strategy for cancer based on the immunological intervention with IL-6 blockade2010
- Author(s)
  吉崎和幸
- Organizer
  EPC Global International Forum of Regional and Targeted Cancer Therapies
- Place of Presentation
  Shanghai, China(招待講演)
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] Immune-pathogenic difference of cytokines in autoimmune disease2010
- Author(s)
  吉崎和幸
- Organizer
  The 14th International Congress of Immunology～Workshop Cytokine regulation in disease～
- Place of Presentation
  神戸
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] RAにおけるIL-6 及びその阻害の臨床意義2009
- Author(s)
  吉崎和幸
- Organizer
  第8回加古川.神戸大学連携カンファレンス
- Place of Presentation
  加古川
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] Role of IL-6 blocking therapy for improvement of autoimmune disease in chronic inflammatory status2009
- Author(s)
  吉崎和幸
- Organizer
  国際炎症学会
- Place of Presentation
  東京
- Year and Date
  2009-07-07
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] 生物学的製剤とアミロイドーシス.2009
- Author(s)
  吉崎和幸
- Organizer
  第7回中ノ島リウマチセミナー,
- Place of Presentation
  大阪
- Year and Date
  2009-12-13
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] Pathogenic role of IL-6 with TNFα or IL-1 on the induction of acute phase proteins2009
- Author(s)
  吉崎和幸
- Organizer
  12^<th> International TNF Conference
- Place of Presentation
  Madrid, Spain
- Year and Date
  2009-04-27
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] Pathogenic role of IL-6 and different mechanism of IL-6 blocking therapy for autoimmune disease at initial immunological phase and late chronic inflammatory phase2009
- Author(s)
  吉崎和幸
- Organizer
  FOCIS2009
- Place of Presentation
  San Francisco, USA
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21659121
[Presentation] .AAアミロイドーシスにおけるIL-6による血清アミロイドAA（SAA）産生メカニズムとそのIL-6標的治療
- Author(s)
  吉崎和幸, PLABHA Tiwari1，中澤宗健, 松村哲平, 荻原圭祐, 伊東大貴
- Organizer
  第42回日本臨床免疫学会
- Place of Presentation
  東京
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] サイトカインによる急性期タンパク（SAA、CRP、Hepcidin）発現機序
- Author(s)
  吉崎和幸，中澤宗健
- Organizer
  第79回日本インターフェロン・サイトカイン学会
- Place of Presentation
  札幌
- Year and Date
  2014-06-19 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] Mechanism of IL-6 induced SAA production and amyloid A deposition in AA Amyloidosis patients with RA
- Author(s)
  Kazuyuki Yoshizaki and Soken-Nakazawa J Song
- Organizer
  XIVth International Symposium on Amyloidosis
- Place of Presentation
  Indianapolis, Indiana, USA.
- Year and Date
  2014-04-27 – 2014-05-01
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] Suppressing Hepcidin by Tocilizumab Effectively Improve Anemia in Inflammatory Diseases: Clinical Evidence and Basic Mechanisms
- Author(s)
  Kazuyuki Yoshizaki、Soken-Nakazawa J. Song　and Hiroshi Kawabata
- Organizer
  The 56th American Society of Hematology (ASH)
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] Tocilizumab is More Effective than Tumor Necrosis Factor-a Inhibitors for Improving Anemia in Rheumatoid Arthritis by Inhibiting Hepcidin Production
- Author(s)
  Soken-Nakazawa J. Song and Kazuyuki Yoshizaki
- Organizer
  MidTerm Conference of ICIS, Interleukin 6 Biology-Pathophysiology-Therapy.
- Place of Presentation
  Kiel, Germany.
- Year and Date
  2014-05-14 – 2014-05-17
- Invited
- Data Source
  KAKENHI-PROJECT-25461452

1. NISHIMOTO Norihiro (80273663)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. MATSUMOTO Tomoshige (10311763)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. SUGIMURA Kazuhisa (80127240)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. OCHI Takahiro (80112035)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Uno Kazuko (50211082)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
6. 山西弘一 (10029811)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 中村秀次 (20237423)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 嶋良仁

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TSUKIHARA Tomitake (00032277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KAWAI Tomoji (20092546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OZAKI Shoichi (00231233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SUGIO Hiromu (50211305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OGAWA Yoshihiro (70291424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TANAKA Masao (10332719)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ITO Yuji (60223195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. HASHIGUCHI Shuhei (40295275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KISHIMOTO Susumu (60028420)

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18. HARA Hideki (10211492)

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19. NEGORO Shigeru (30172753)

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20. Nakazawa Soken (00535958)

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21. Tomosugi Naohisa (80155580)

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22. Kawabata Hiroshi (10329401)

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23. Ito Hiroki (60590635)

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24. 松島綱治 (50222427)

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26. 栗谷太郎 (30161756)

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27. 伊藤裕章 (40252639)

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33. KUBAGAWA Hiromi

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34. UEKI Tatzuo

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35. HIGUCHI Naohisa

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36. OOMOTO Yasuichi

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37. NAKASHIMA Toshihiro

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38. TANIGAWA Miki

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39. 安藤駿作

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40. 小川弘之

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41. ANDERSON Ken

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42. ANDERSON Kenneth C.

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43. KUBAGAWA HIi

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44. 上坪宏道

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45. 江島大輔

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YOSHIZAKI KAZUYUKI 吉崎 和幸

吉崎 和幸 ヨシザキ カズユキ

Yoshizaki Kazuyuki 吉崎 和幸

YOSHIZAKI Kazuyuki 吉崎 和幸

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Detection of biomarkers in pre-treatment serum which predict the clinical remission on the treatment with biologics in rheumatoid arthritis.Principal Investigator

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有機低分子によるインターロイキン6同属分子の機能的重複と多様性機序解明と臨床応用Principal Investigator

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ファージライブラリーを用いたIL-6阻害ヒト抗体および低分子癌抑制分子の開発Principal Investigator

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The roles of pro-inflammatory cytokines on induction of acute phase proteins in inflammatory diseasesPrincipal Investigator

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キャッスルマン病の病因・病態解析とIL-6阻害による治療研究Principal Investigator

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多発性骨髄腫のサイトカインシグナル伝達におけるネガティブフォードバック機構の解析-SSI-1導入による遺伝子治療の試み-Principal Investigator

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YOSHIZAKI KAZUYUKI 吉崎和幸

吉崎和幸ヨシザキカズユキ

Yoshizaki Kazuyuki 吉崎和幸

YOSHIZAKI Kazuyuki 吉崎和幸