KUROSAKI Yuji 黒崎勇二

Researcher Number	90161786
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2021: 岡山大学, 医歯薬学域, 教授 2016 – 2020: 岡山大学, 医歯薬学総合研究科, 教授 2012 – 2015: 岡山大学, 医歯(薬)学総合研究科, 教授 2005 – 2011: 岡山大学, 大学院・医歯薬学総合研究科, 教授 2006: Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 … More 2001 – 2004: Okayama University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 1999 – 2000: Okayama University, Graduate School of Natural Science and Technology, Associate Professor, 大学院・自然科学研究科, 助教授 1998: 岡山大学, 薬学部, 助教授 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / 応用薬理学・医療系薬学 Except Principal Investigator 応用薬理学・医療系薬学 / Medical pharmacy / Applied pharmacology
Keywords	Principal Investigator マイクロダイアリシス / 微小透析 / 含水ゲルシート / 固体分散体 / 局所利用率 / 薬物動態 / N-251 / L-HPC / マイクロニードル / 経皮的薬物送達 … More / percutaneous absorption / microdialysis / local bioavailability / local pharmacokinetics / 経皮吸収 / 局所体内動態 / 局所薬物動態 / 筋肉 / 局所 / 薬物送達 / ドラッグデリバリー / 溶解特性改善 / 皮膚透過性改善 / 難溶性薬物 / 経皮適用型製剤 / L-HPC含水ゲルシート / 皮膚透過障壁 / 抗マラリア薬 / 抗マラリア / 薬物透過障壁 / ナノファイバー / 角質層侵襲 / 過飽和形成製剤 / デコンボリューション / 吸着動態補正 / 局所薬物動態モニタリング / 局所適用型DDS / drug delivery system / controlled-release / teicoplanin / antibody / ブラジキニン / ケトプロフェン / 薬物モニタリング / ドラッグデリバリーシステム / 放出制御製剤 / テイコプラニン / 抗体 / zero-net-flux / colonic absorption / lipo-microdialysis / drug delivery system (DDS) / 薬力学 / 薬動学 / 潰瘍性大腸炎 / ゼロ・ネット・フラックス法 / 大腸吸収 / リポ・マイクロダイアリシス / ドラッグデリバリーシステム(DDS) / 微小透析（マイクロダイアリシス） / 局所血流 / 筋肉内拡散動態 / 吸着動態 / 時間遅れ補正 / 遊離形薬物濃度 / 局所冷却 / 筋肉内薬物拡散動態 / 拡散モデル / ファーマコキネティクス / ドドラッグデリバリーシステム / lipo-MD / 血流 / Lipo-MD / モニタリング / 局所動態 / 限局 / 製剤学 … More Except Principal Investigator 交感神経 / 抵抗血管 / 血管拡張性神経 / 腸間膜動脈 / 血管周囲神経機能 / NKCC1 / 腎障害 / Pharmacodynamics / TRPVl / NKCCl / unidine / Tolhutamide / Cephalexin / Pharmacokinetics / Renal failure / 分布容積 / タンパク結合 / 腹膜透析 / アベイラビリティ / 尿毒症物質 / 消化管神経叢 / ファーマコダイナミクス / TRPV1 / キニジン / トルブタミド / セファレキシン / ファーナコキネティクス / Angiotensin II type 2 receptor / Nerve growth factor / Perivascular nerve remodeling / Reinnervating substance / Denervation method by Phenol / CGRPergic nerves / Sympathetic nerves / Perivascular nerves / 神経リモデリング / 神経再生物質 / Angiotensin II / 高血圧自然発症ラット(SHR) / In vivo除神経 / Phenol塗布除神経法 / Angiotensin II type 2受容体 / 神経成長因子 / 血管周囲神経リモデリング / 神経再生・再分布物質 / Phellol塗布除神経法 / CGRP神経 / 血管周囲神経 / Rat mesenteric resistance artery / Proton / Adrenergic neurotransmitters / Vanilloid receptors / Nicotine / Calcitonin gene-related peptide (CGRP)-nerves / Sympathetic adrenergic nerves / 神経伝達物質 / プロトン / ラット / バニロイド受容体 / ニコチン性コリン受容体 / CGRP作動性神経 / ADRENERGIC NERVE / MESENTERIC RESISTANCE ARTERY / CALCITONIN GENE-RELATED PEPTIDE-CONTAINING NERVE / INSULIN-RESISTANT RAT / PERIARTERIAL NERVE FUNCTION / VASCULAR RESPONSIVENESS / INSULIN / 血管内皮機能 / 含硫アミノ酸タウリン / アンジオテンシンII受容体拮抗薬 / インスリン抵抗性改善薬 / 血管拡張性CGRP神経機能 / 血管収縮性交感神経機能 / インスリン抵抗性 / adrenergic nerve / mesenteric resistance artery / calcitonin gene-related peptide / spontaneously hypertensive rats / periarterial nerve function / long-term treatment / antihypertensive drugs / 自然発生高血圧ラット / 抗高血圧薬薬 / 高血圧自然発生ラット / アドレナリン作動性神経 / カルシトニン遺伝子関連ペプチド / 高血圧自然発症ラット / 長期投与 / 抗高血圧薬 / 投与設計 / 薬物療法 / 薬物感受性 / 個体差 / 腎不全 / CYP3A2 / テーラーメード医療 / 炎症 / CYP3A / 中枢神経 / 脈絡叢 / 発現変動 / 薬物代謝酵素 / 肝代謝 / 薬効変動 Less

難溶性薬物の過飽和形成製剤と直接的皮膚侵襲による経皮的送達法の応用基盤の構築Principal Investigator
- Principal Investigator
  
  黒崎勇二
- Project Period (FY)
  2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Okayama University
Utilization of supersaturated dosage form and micro-puncture formation on skin to a new transdermal drug deliveryPrincipal Investigator
- Principal Investigator
  
  Kurosaki Yuji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Okayama University
Dosage design and its evaluation for topically applicable DDS by focal unbound drug concentration monitoringPrincipal Investigator
- Principal Investigator
  
  Kurosaki Yuji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Evaluation of focal availabilities of drugs by monitoring of dynamic diffusion and clearance processes of unbound drug concentrationsPrincipal Investigator
- Principal Investigator
  
  KUROSAKI Yuji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Understanding mechanisms underlying an increased sensitivity of central nervous system to therapeutic compounds with decreased renal function for dose optimization and individualizing treatment
- Principal Investigator
  
  AIBA Tetsuya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Application of microdialysis techniques to evaluation system for local pharmacokinetics of topically delivered drugs guaranteeing regionally confined drug actionPrincipal Investigator
- Principal Investigator
  
  KUROSAKI Yuji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Evaluation system for local pharmacokinetics of topically delivered drugs guaranteeing regionally confined drug actionPrincipal Investigator
- Principal Investigator
  
  KUROSAKI Yuji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Mechanisms responsible for interindividual variability of bioavailability of therapeutic compounds in patients with acute renal failure and related homeostasis perturbation
- Principal Investigator
  
  AIBA Tetsuya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Study on novel drugs ameliorating perivascular nerve remodeling
- Principal Investigator
  
  KAWASAKI Hiromu
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  OKYAMA UNIVERSITY
Estimation of Local Bioavailability for Transdermally Applied Drugs by the Monitoring of Unboud-form Drug Concentrations in the SkinPrincipal Investigator
- Principal Investigator
  
  KUROSAKI Yuji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  OKAYAMA UNIVERSITY
Perivascular Sympathetic Nerve-Mediated Vasodilation in The Rat Mesenteric Resistance Artery
- Principal Investigator
  
  KAWASAKI Hiromu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  OKAYAMA UNIVERSITY
Estimation of Local Bioavailability for Locally Acting Drug Delivery Systems by Pharmacokinetic- and Pharmacodynamic-MeasurementPrincipal Investigator
- Principal Investigator
  
  KUROSAKI Yuji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  OKAYAMA UNIVERSITY
Vascular effect of insulin as a vasoactive peptide and its resistance
- Principal Investigator
  
  KAWASAKI Hiromu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  OKAYAMA UNIVERSITY
Establishment of evaluating methods for novel antihypertensive drugs acting on perivascular nerve function in SHR
- Principal Investigator
  
  KAWASAKI Hiromu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  OKAYAMA UNIVERSITY

[Journal Article] Comparative study on altered hepatic metabolism of CYP3A substrates in rats with glycerol-induced acute renal failure2012
- Author(s)
  Kusaba J-I, Kajikawa N, Kawasaki H, Kurosaki Y, Aiba T
- Journal Title
  
  Biopharm Drug Dispos
  
  Volume: 33 Pages: 22-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590159
[Journal Article] Pharmacodynamic characterization of nitric oxide-mediated vasodilatory activity in isolated perfused rat mesenteric artery bed2011
- Author(s)
  Shinnsuke Inoue, Tetsuya Aiba, Yasuyuki Masaoka, Keiko Shimizu, Yukiko Komori, Mitsunobu Mio, Shingo Takatori, Hiromu Kawasaki, Yuji Kurosaki
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 34(9) Pages: 1487-1492
- NAID
  130001872445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590161
[Journal Article] 薬物の筋肉内拡散・分布動態に及ぼす血流量の影響:局所冷却時の動態特性2011
- Author(s)
  牧之段敬一, 東恩納司, 村上仁美, 合葉哲也, 黒崎勇二
- Journal Title
  
  日本薬剤学会第26年会講演要旨集
  
  Pages: 141-141
- Data Source
  KAKENHI-PROJECT-21590161
[Journal Article] Pharmacodynamic characterization of nitric oxide-mediated vasodilatory activity in isolated perfused rat mesenteric artery bed2011
- Author(s)
  Inoue S, Aiba T, Masaoka Y, Shimizu K, Komori Y, Mio M, Takatori S, Kawasaki H, Kurosaki Y
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 34 Pages: 1487-1492
- NAID
  130001872445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590159
[Journal Article] 血管平滑筋弛緩作用の薬力学モデル解析2010
- Author(s)
  合葉哲也, 井上真輔, 正岡康幸, 清水けい子, 小森有希子, 高取真吾, 見尾光庸, 川崎博己, 黒崎勇二
- Journal Title
  
  日本薬学会第130年会要旨集
  
  Volume: 4 Pages: 265-265
- Data Source
  KAKENHI-PROJECT-21590161
[Journal Article] Microdialysis study in evaluation of intramuscular lateral distribution profiles of topically administered drugs inrats2010
- Author(s)
  Tsukasa Higashionna, Hitomi Murakami, Keiichi Makinodan, Kozue Kanda, Mayu Shibata, Tetsuya Aiba, Yuji Kurosaki
- Journal Title
  
  25th JSSX Annual Meetingin Tokyo Abstracts
  
  Pages: 219-219
- Data Source
  KAKENHI-PROJECT-21590161
[Journal Article] 脂肪乳剤を用いた微小透析法(Lipo-MD法):薬物の脂溶性が透析特性に及ぼす影響2010
- Author(s)
  岡大嗣, 小林徹, 合葉哲也, 黒崎勇二
- Journal Title
  
  第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会講演要旨集
  
  Pages: 187-187
- Data Source
  KAKENHI-PROJECT-21590161
[Journal Article] Altered electrolyte handling of the choroid plexus in rats with glycerol-induced acute renal failure2010
- Author(s)
  Ishikawa A, Kono K, Sakae R, Aiba T, Kawasaki H, Kurosaki Y
- Journal Title
  
  Biopharm Drug Dispos
  
  Volume: 31 Pages: 455-463
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590159
[Journal Article] 脂肪乳剤を用いた微小透析法(Lipo-MD法)の透析特性:濃度変化に対する追随性の従来法との比較2009
- Author(s)
  小林徹, 合葉哲也, 黒崎勇二
- Journal Title
  
  第48回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会講演要旨集
  
  Pages: 113-113
- Data Source
  KAKENHI-PROJECT-21590161
[Journal Article] Comparative study of increased plasma quinidine concentration in rats with glycerol-and cisplatin-induced acute renal failure2009
- Author(s)
  Izuwa Y, Kusaba J-I, Horiuchi M, Aiba T, Kawasaki H, Kurosaki Y
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 24 Pages: 451-457
- NAID
  10025724709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590159
[Journal Article] Evaluation of intramuscular lateral distribution profile of topically administered acetaminophen in rats2007
- Author(s)
  Yuji Kurosaki, Masahiro Tagawa, Akiho Omoto, Hiroshi Suito, Yukiko Komori, Hiromu Kawasaki, Tetsuya Aiba
- Journal Title
  
  Int. J. Pharm. 343(1-2)
  
  Pages: 190-195
- NAID
  120002307079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590143
[Journal Article] Evaluation of intramuscular lateral distribution profile of topically administered acetaminophen in rats2007
- Author(s)
  Yuji Kurosaki, et. al.
- Journal Title
  
  International Journal of Pharmaceutics 343
  
  Pages: 190-195
- NAID
  120002307079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590141
[Journal Article] Evaluation of intramuscular lateral distribution profile of topically administered acetaminophen in rats2007
- Author(s)
  Yuji Kurosaki
- Journal Title
  
  International Journal of Pharmaceutics 343
  
  Pages: 190-195
- NAID
  120002307079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590143
[Journal Article] Evaluation of intramuscular lateral distribution profile of topically administered acetaminophen in rats2007
- Author(s)
  Yuji, Kurosaki, et. al.
- Journal Title
  
  International Journal &Pharmaceutics 343(1-2)
  
  Pages: 190-195
- NAID
  120002307079
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590141
[Journal Article] Chronic Hyperinsulinemia Enhances Adrenergic Vasoconstriction and Decreases CGRPergic Nerve-Mediated Vasodilation in Pithed Rats.2006
- Author(s)
  S Takatori, Y Zamami, M Mio, Y Kurosaki, H Kawasaki
- Journal Title
  
  Hypertens Res 29
  
  Pages: 361-368
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390157
[Journal Article] Chronic Hyperinsulinemia Enhances Adrenergic Vasoconstriction and Decreases CGRPergic Nerve-Mediated Vasodilation in Pithed Rats.2006
- Author(s)
  Shingo Takatori, Yoshito Zamami, Mitsunobu Mio, Yuji Kurosaki, Hiromu Kawasaki
- Journal Title
  
  Hypertension Research 29
  
  Pages: 361-368
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390157
[Journal Article] Long-term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP) containing nerves in spontaneously hypertensive rats.2005
- Author(s)
  Narumi Hobara, Noriko Gessei-Tsutsumi, Mitsuhiro Goda, Fusako Takayama, Shinji Akiyama, Yuji Kurosaki, Hiromu Kawasaki
- Journal Title
  
  Hypertension Research 28
  
  Pages: 465-474
- NAID
  10016625320
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390157
[Journal Article] Long-term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP) containing nerves in spontaneously hypertensive rats2005
- Author(s)
  N.Hobara, N.Gessei-Tsutsumi, M.Goda, F.Takayama, S.Akiyama, Y.Kurosaki, H.Kawasaki
- Journal Title
  
  Hypertens Res 28
  
  Pages: 465-474
- NAID
  10016625320
- Data Source
  KAKENHI-PROJECT-16390157
[Journal Article] Long-term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP) containing nerves in spontaneously hypertensive rats2005
- Author(s)
  NHobara, N.Gessei-Tsutsumi, M Goda, F Takayama, S Akiyama, Y Kurosaki, H Kawasaki
- Journal Title
  
  Hypertens Res 28
  
  Pages: 465-474
- NAID
  10016625320
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390157
[Journal Article] マイクロダイアリシスを利用した経皮吸収製剤の局所薬物利用率評価の試み2003
- Author(s)
  畑中潤一, 黒崎勇二
- Journal Title
  
  Drug Delivery System 18
  
  Pages: 220-220
- NAID
  10011106045
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590132
[Journal Article] Estimation of loal bioavailability of transdermal therapeutic systems by microdialysis.2003
- Author(s)
  Jun-ichi Hatanaka, Yuji Kurosaki
- Journal Title
  
  Drug Delivery System 18(3)
  
  Pages: 220-220
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590132
[Presentation] 新しいマラリア治療薬の開発ー過酸化物をベースにした軟膏製剤の基礎研究ー2022
- Author(s)
  光永　朋樹、松森　宏明、右馬　野栞、松尾美咲、クエンディンティ、チャン　キョンス、佐藤　聡、黒崎勇二、三好伸一、金　惠淑
- Organizer
  日本薬学会　第１４２年会
- Data Source
  KAKENHI-PROJECT-21K06492
[Presentation] 新しいマラリア治療薬の開発̶－軟膏製剤としての実用化に向けた基礎研究2021
- Author(s)
  井黒香奈⼦、五十川怜奈、池田奈々子、黒崎勇二、Kyung-Soo Chang、金惠淑
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06595
[Presentation] 新しい抗マラリア薬候補・環状過酸化軟膏製剤の実用化に向けた基礎研究2021
- Author(s)
  松森　宏明、井黒　香奈子、池田　奈々子、佐藤　聡、黒崎勇二、Kyung-Soo Chang、金　惠淑
- Organizer
  第76回日本寄生虫学会西日本支部大会
- Data Source
  KAKENHI-PROJECT-21K06492
[Presentation] 新しいマラリア治療薬の開発̶－過酸化物をベースにした軟膏製剤の基礎研究2020
- Author(s)
  井黒香奈⼦、五十川怜奈、池田奈々子、黒崎勇二、Kyung-Soo Chang、金惠淑
- Organizer
  グローバルヘルス合同大会2020
- Data Source
  KAKENHI-PROJECT-18K06595
[Presentation] Basic Research into Practical Use of Transdermal Type-Antimalarial N-892018
- Author(s)
  Ryoka Ishii, Machiko Makita, Ayano Ochi, Mayuko Miyoshi, Rena Isogawa, Sakura Ono, Kyung-Soo Chang, Yuji Kurosaki, Hye-Sook Kim
- Organizer
  Forum Cheju 19 (The 19th Japan-Korea Parasitologists’ Seminar)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08073
[Presentation] Dermal super-saturated delivery (DSSD) of antimalarial-endoperoxides: A new strategy for dosage form designing.2018
- Author(s)
  Yuji Kurosaki, Keisuke Sasaoka, Rina Morikami and Nana Taira
- Organizer
  14th International Congress of Parasitology (ICOPA 2018) , Daegu, Korea, 8.19-24, 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06595
[Presentation] 経皮吸収型抗マラリア薬の実用化に向けた基礎研究2018
- Author(s)
  石井涼香、槇田真千子、越智彩乃、三次真悠子、五十川怜奈、王野さくら、佐藤聡、黒崎勇二、金惠淑
- Organizer
  第87回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-15K08073
[Presentation] New transdermal type-antimalarial drug development research2017
- Author(s)
  Hye-Sook Kim, Machiko Makita, Ryoka Ishi, Mayuko Miyoshi, Yuji Kurosaki, Kyung-Soo Chang
- Organizer
  The 59th Annual Meeting of the Korean Society for Parasitology and Tropical Medicine (2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08073
[Presentation] 抗マラリア活性を有する環状過酸化物N-251の固体分散体化による溶解特性の改善2016
- Author(s)
  藤原帆波、山下功祐、金惠淑、黒崎勇二
- Organizer
  第55回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  岡山市
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-15K08073
[Presentation] 微小透析法を応用した局所薬物動態評価：同時灌流Zero-net-flux法の可能性2013
- Author(s)
  崎山達矢、皆川貴彰、黒崎勇二
- Organizer
  第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  松山市
- Data Source
  KAKENHI-PROJECT-24590193
[Presentation] Evaluation of dynamic diffusion process for developing focally acting DDSs: Improvement of focal bioavailability by topical cooling.2012
- Author(s)
  Atsushi Osanaga, Keiichi Makinodan, Tatsuya Sakiyama, Tetsuya Aiba, Yuji Kurosaki
- Organizer
  第6回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-24590193
[Presentation] 薬物の筋肉内拡散・分布動態に及ぼす血流量の影響:局所冷却時の動態特性2011
- Author(s)
  牧之段敬一, 東恩納司, 村上仁美, 合葉哲也, 黒崎勇二
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] Microdialysis study in evaluation of intramuscular lateral distribution profiles of topically administered drugs in rats2010
- Author(s)
  Tsukasa Higashionna, Hitomi Murakami, Keiichi Makinodan, Kozue Kanda, Mayu Shibata, Tetsuya Aiba, Yuji Kurosaki
- Organizer
  日本薬物動態学会第25回年会(25th JSSX Annual Meeting in Tokyo)
- Place of Presentation
  大宮ソニックシティ
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] 血管平滑筋弛緩作用の薬力学モデル解析2010
- Author(s)
  合葉哲也、井上真輔、正岡康幸、清水けい子、小森有希子、高取真吾、見尾光康、川崎博己、黒崎勇二
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター(岡山市)
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] Microdialysis study in evaluation of intramuscular lateral distribution profiles of topically administered drugs in rats2010
- Author(s)
  TsukasaHigashionna, Hitomi Murakami, Keiichi Makinodan, Kozue Kanda, Mayu Shibata, Tetsuya Aiba, Yuji Kurosaki
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] 血管平滑筋弛緩作用の薬力学モデル解析2010
- Author(s)
  合葉哲也, 井上真輔, 正岡康幸, 清水けい子, 小森有希子, 高取真吾, 見尾光庸, 川崎博己, 黒崎勇二
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山市
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] 脂肪乳剤を用いた微小透析(Lipo-MD法):薬物の脂溶性が透析特性に及ぼす影響2010
- Author(s)
  岡大嗣、小林徹、合葉哲也、黒崎勇二
- Organizer
  第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  米子コンベンションセンター、米子市文化ホール
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] 脂肪乳剤を用いた微小透析法(Lipo-MD法):薬物の脂溶性が透析特性に及ぼす影響2010
- Author(s)
  岡大嗣, 小林徹, 合葉哲也, 黒崎勇二
- Organizer
  第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  米子市
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] 脂肪乳剤を用いたマイクロダイアリシス法(Lipo-MD法)の局所薬物動態評価への応用2009
- Author(s)
  小林徹、合葉哲也、政田幹夫、黒崎勇二
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡県コンベンションアーツセンター(静岡市)
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] 脂肪乳剤を用いた微小透析法(Lipo-MD法)の透析特性:濃度変化に対する追随性の従来法との比較2009
- Author(s)
  小林徹, 合葉哲也, 黒崎勇二
- Organizer
  第48回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  徳島市
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] 脂肪乳剤を用いた微小透析法(Lipo-MD法)の透析特性 : 濃度変化に対する追随性の従来法との比較2009
- Author(s)
  小林徹、合葉哲也、黒崎勇二
- Organizer
  第48回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  アスティ徳島(徳島市)
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] 微小透析を用いた薬物の局所動態評価 : フェニレフリンの筋肉内拡散動態と局所血流変化2008
- Author(s)
  柴田麻佑, 神田梢恵, 合葉哲也, 黒崎勇二
- Organizer
  第4 7回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  岡山コンベンションセンター
- Data Source
  KAKENHI-PROJECT-19590143
[Presentation] 微小透析法を用いた薬物の局所動態評価 : フェニレフリンの筋肉内拡散動態と局所血流変化2008
- Author(s)
  柴田麻佑, 神田梢恵, 合葉哲也, 黒崎勇二
- Organizer
  第47回日本薬学会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  岡山市
- Year and Date
  2008-11-09
- Data Source
  KAKENHI-PROJECT-19590143
[Presentation] 微小透析を用いた薬物の筋肉組織内拡散過程の評価2008
- Author(s)
  神田梢恵, 小林徹, 田川真大, 大元章帆, 小森有希子, 合葉哲也, 黒崎勇二
- Organizer
  日本薬剤学会第2 3年会
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-19590143

1. AWASAKI Hiromu (60125151)

# of Collaborated Projects: 11 results

# of Collaborated Products: 14 results
2. AIBAK Tetsuya (00231754)

# of Collaborated Projects: 5 results

# of Collaborated Products: 25 results
3. KIM Hye-Sook (70314664)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. KOMORI Yukiko (80379734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUROSAKI Yuji 黒崎 勇二

Research Projects

Research Products

Co-Researchers

難溶性薬物の過飽和形成製剤と直接的皮膚侵襲による経皮的送達法の応用基盤の構築Principal Investigator

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Utilization of supersaturated dosage form and micro-puncture formation on skin to a new transdermal drug deliveryPrincipal Investigator

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Dosage design and its evaluation for topically applicable DDS by focal unbound drug concentration monitoringPrincipal Investigator

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Evaluation of focal availabilities of drugs by monitoring of dynamic diffusion and clearance processes of unbound drug concentrationsPrincipal Investigator

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Understanding mechanisms underlying an increased sensitivity of central nervous system to therapeutic compounds with decreased renal function for dose optimization and individualizing treatment

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Application of microdialysis techniques to evaluation system for local pharmacokinetics of topically delivered drugs guaranteeing regionally confined drug actionPrincipal Investigator

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Evaluation system for local pharmacokinetics of topically delivered drugs guaranteeing regionally confined drug actionPrincipal Investigator

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Mechanisms responsible for interindividual variability of bioavailability of therapeutic compounds in patients with acute renal failure and related homeostasis perturbation

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Study on novel drugs ameliorating perivascular nerve remodeling

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Estimation of Local Bioavailability for Transdermally Applied Drugs by the Monitoring of Unboud-form Drug Concentrations in the SkinPrincipal Investigator

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Perivascular Sympathetic Nerve-Mediated Vasodilation in The Rat Mesenteric Resistance Artery

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Estimation of Local Bioavailability for Locally Acting Drug Delivery Systems by Pharmacokinetic- and Pharmacodynamic-MeasurementPrincipal Investigator

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Vascular effect of insulin as a vasoactive peptide and its resistance

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KUROSAKI Yuji 黒崎勇二