Mitomi Hiroyuki 三富弘之

… Alternative Names

MITOMI Hiroyuki 三富弘之

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Researcher Number	90181940
Affiliation (Current)	2025: 順天堂大学, 医学部, 非常勤講師 2025: 独立行政法人国立病院機構(相模原病院臨床研究センター), その他部局等, その他
Affiliation (based on the past Project Information) *help	2015 – 2018: 順天堂大学, 医学部, 非常勤講師 2012 – 2014: 獨協医科大学, 医学部, 教授 2011: 独立行政法人国立病院機構(相模原病院臨床研究センター), 政策医療企画部, 研究員 2011: 順天堂大学, 医学部, 准教授 2010: 独立行政法人国立病院機構(相模原病院臨床研究センター), 病態総合研究部, 研究員 … More 2009: Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, 病態総合研究部, 特別研究員 2009: 独立行政法人国立病院機構(相模原病院臨床研究センター), 病態総合研究部, 特別研究員 2008: 独立行政法人国立病院機構(相模原病院臨床研究センター), 検査科(病理), 課長 2008: 独立行政法人国立病院機構(相模原病院臨床研究センター), 検査科, 科長 2007: Clinical Research Center, National Hospital Organization Sagamihara Hospital, Department of Pathomechanisms, Chief Physician 2006 – 2007: 独立行政法人国立病院機構(相模原病院臨床研究センター), 研究検査科, 科長 Less
Review Section/Research Field	Principal Investigator Human pathology Except Principal Investigator Orthopaedic surgery / Human pathology / Digestive surgery
Keywords	Principal Investigator マイクロRNA / 大腸 / 大腸癌 / 遺伝子メチル化 / 炎症発癌 / 潰瘍性大腸炎 / 発癌経路 / 鋸歯状腺癌 / 広基性鋸歯状ポリープ / Wntシグナル … More / 発癌 / 大腸ポリープ / 鋸歯状発癌経路 / 広基性鋸歯状腺腫/ポリープ / microRNA / ポリープ / 消化器・唾液腺 / EphB2 / Pathched / micro RNA / 消火器・唾液腺 / DNAミスマッチ修復遺伝子 / 大腸腫瘍 / 鋸歯状ポリープ … More Except Principal Investigator 変形性関節症 / p16INK4a / Hedgehogシグナル伝達経路 / Wntシグナル伝達経路 / GTP結合蛋白関連シグナル伝達経路 / Wnt/β-catenin系 / micro RNA / 膵管内乳頭状粘液産生腫瘍 / CD133 / TGF-β / マイクロRNA / 膵臓癌 / IPMN / Akt/mTOR / Wnt/β-catenin / シグナル伝達経路 / miR20-a / miR181b / miR21 / 膵管内乳頭粘液性腫瘍 / Promoter Methylation / Prognosis / Colorectal cancer / 予後規定因子 / メチル化 / 遺伝子プロモーター / 簇出 / 大腸癌 / 病理学 / 遺伝子 / 癌 / 外科 / プロモーターメチレーション / 予後 / 大腸がん / 遺伝子変異 / シグナル伝達 / 胃癌 / cDNAマイクロアレイ / サイトカイン / 関節軟骨 / 滑膜 / 関節液 / マイクロアレイ / 軟骨変性因子 / 腫瘍破死因子 / 関節リウマチ / 切断酵素 / 腫瘍壊死因子 Less

The relationship of microRNA expression on the signaling pathway activation in pancreatic intraductal papillary mucinous neoplasm
- Principal Investigator
  
  Fukumura Yuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Juntendo University
MicroRNA dysregulation and signal pathway activation in ulcerative colitids-associated carcinogenesisPrincipal Investigator
- Principal Investigator
  
  MITOMI Hiroyuki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Juntendo University
Micro RNA expression in serrated pathway and its association with a potential target therapyPrincipal Investigator
- Principal Investigator
  
  MITOMI Hiroyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Dokkyo Medical University
胃底腺型胃癌におけるHedgehog/Wntシグナル伝達系の関与
- Principal Investigator
  
  伊藤浩一
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Juntendo University
Epigenetic modification of micro RNA expression in serrated polyp-carcinoma pathwayPrincipal Investigator
- Principal Investigator
  
  MITOMI Hiroyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
変形性関節症罹患軟骨の層間の比較によるタンパク分解酵素発現機序の解明
- Principal Investigator
  
  福井尚志
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
Exploration of possible catabolic factors in osteoarthritis through the analysis of large numbers of human samples.
- Principal Investigator
  
  FUKUI Naoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
Investigation for the mechanism of shedding for tumor necrosis factor-α and its pathological significance in rheumatoid arthritis
- Principal Investigator
  
  HIKITA Atuhiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
Prognosis value of aberrant p16^<INK4a> gene methylation in colorectal cancer
- Principal Investigator
  
  KANAZAWA Hideki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital

All 2017 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] A case of Krukenberg carcinoma metastasized from colon cancer resembling mucinous cystadenocarcinoma of the ovary2014
- Author(s)
  Shiono S, Saito T, Fujii H, Arakawa A, Nakamura T, Yao T
- Journal Title
  
  Int J Clin Exp Pathol
  
  Volume: 7 Issue: 1 Pages: 394-401
- DOI
  10.1038/modpathol.2014.41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590434, KAKENHI-PROJECT-24590429
[Journal Article] Distinct profile of HIF1α, PTCH, EphB2 or DNA repair protein expression and BRAF mutation in colorectal serrated adenoma.2014
- Author(s)
  Morimoto T, Mitomi H, Saito T, Takahashi M, Murakami T, Sakamoto N, Yao T, Watanabe S:
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 印刷中 Issue: 6 Pages: 1192-1199
- DOI
  10.1111/jgh.12553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590429
[Journal Article] Downregulation of sFRP-2 by epigenetic silencing activates the β-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma.2014
- Author(s)
  Saito T, Mitomi H, Imamhasan A, Hayashi T, Mitani K, Takahashi M, Kajiyama Y, Yao T:
- Journal Title
  
  Virchows Arch
  
  Volume: 464 Issue: 2 Pages: 135-143
- DOI
  10.1007/s00428-014-1538-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590429
[Journal Article] Protein expression and methylation of DNA repair genes hMLH1, hMSH2, MGMT and BRCA1 and their correlation with clinicopathological parameters and prognosis in basal-like breast cancer.2013
- Author(s)
  Alkam Y, Mitomi H, Nakai K, Himuro T, Saito T, Takahashi M, Arakawa A, Yao T, Saito M:
- Journal Title
  
  Histopathology
  
  Volume: 63 Issue: 5 Pages: 713-725
- DOI
  10.1111/his.12220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590429
[Journal Article] Alteration in the Wnt/β-catenin signaling pathway in gastric neoplasias of fundic gland (chief cell predominant) type.2013
- Author(s)
  Hidaka Y, Mitomi H, Saito T, Takahashi M, Lee SY, Matsumoto K, Yao T, Watanabe S:
- Journal Title
  
  Hum Pathol
  
  Volume: 44 Issue: 11 Pages: 2438-2448
- DOI
  10.1016/j.humpath.2013.06.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590429
[Journal Article] Immunohistochemical analysis of chromogranin A and p53 expression in ulcerative colitis-associated neoplasia: neuroendocrine differentiation as an early event in colitis-neoplasia sequence2013
- Author(s)
  Shigaki K, Fujimori T (11人中3番目)
- Journal Title
  
  Human Pathology
  
  Volume: 44 Issue: 11 Pages: 2393-2399
- DOI
  10.1016/j.humpath.2013.06.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590410, KAKENHI-PROJECT-24590429, KAKENHI-PROJECT-25460413
[Journal Article] Expression of polycomb group proteins EZH2 and Bmi-1 during progression of esophageal squamous intraepithelial neoplasia: An association with p16INK4a and p53.2013
- Author(s)
  Uchida S, Saito T, Mitomi H, Hayashi T, Tomita N, Kajiyama Y, Wada R, Yao T:
- Journal Title
  
  Juntendo Medical Journal
  
  Volume: 59 Pages: 331-339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590429
[Journal Article] Possible involvement of p53 genetic alteration associated with protein overexpression in malignant transformation of giant-cell tumor of bone.2013
- Author(s)
  Okubo T, Saito T, Mitomi H, Takagi T, Torigoe T, Suehara Y, Yao T, Kaneko K.
- Journal Title
  
  Virchows Arch
  
  Volume: 63 Issue: 1 Pages: 67-77
- DOI
  10.1007/s00428-013-1435-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590434, KAKENHI-PROJECT-24590429, KAKENHI-PROJECT-25861342
[Journal Article] MUC5AC/β-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors.2012
- Author(s)
  2) Nakae K, Mitomi H, Saito T, Takahashi M, Morimoto T, Hidaka Y, Sakamoto N, Yao T, Watanabe S.
- Journal Title
  
  World J Gastroenterol.
  
  Volume: 18 Issue: 39 Pages: 5551-9
- DOI
  10.3748/wjg.v18.i39.5551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590429
[Journal Article] Predictive value of MGMT, hMLH1, hMSH2 and BRCA1 protein expression for pathological complete response to neoadjuvant chemotherapy in basal-like breast cancer patients2012
- Author(s)
  Nakai K, Mitomi H, Alkam Y, Arakawa A, Yao T, Tokuda E, Saito M, Kasumi F.
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 69(4) Pages: 923-30
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] Clear cell variant of squamous cell carcinoma originating in the esophagus : Report of a case with immunohistochemical and oncogenetic analyses2012
- Author(s)
  Imamhasan A, Mitomi H (Equal contribution to the first author), Saito T, Arakawa A, Yao T
- Journal Title
  
  Pathol Int
  
  Volume: 62 Issue: 2 Pages: 137-143
- DOI
  10.1111/j.1440-1827.2011.02758.x
- NAID
  10031185179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] Low-grade myofibroblastic sarcoma of the distal femur2012
- Author(s)
  Saito T, Suehara Y et al.
- Journal Title
  
  International Journal of Surgery Case Reports
  
  Volume: 4 Issue: 2 Pages: 195-199
- DOI
  10.1016/j.ijscr.2012.11.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791405, KAKENHI-PROJECT-24590429
[Journal Article] Intraneural lipomatous tumor of the median nerve: Three case reports with a review of literature2012
- Author(s)
  Okubo T, Suehara Y et al.
- Journal Title
  
  International Journal of Surgery Case Reports
  
  Volume: 3 Issue: 9 Pages: 407-411
- DOI
  10.1016/j.ijscr.2012.05.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791405, KAKENHI-PROJECT-24590429
[Journal Article] Immunohistochemical and oncogenetic analyses of the esophageal basaloid squamous cell carcinoma in comparison with conventional squamous cell carcinomas.2012
- Author(s)
  4) Imamhasan A, Mitomi H, Saito T, Hayashi T, Takahashi M, Kajiyama Y, Yao T.
- Journal Title
  
  Hum Pathol.
  
  Volume: 43 Issue: 11 Pages: 2012-23
- DOI
  10.1016/j.humpath.2012.02.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590429
[Journal Article] Clear cell variant of squamous cell carcinoma originating in the esophagus : report of a case with immunohistochemical and oncogenetic analyses2012
- Author(s)
  Imamhasan A, Mitomi H, Saito T, Arakawa A, Yao T.
- Journal Title
  
  Pathol Int
  
  Volume: 62(2) Pages: 137-43
- NAID
  10031185179
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] Immunohistochemical and oncogenetic analyses of the esophageal basaloid squamous cell carcinoma in comparison with conventional squamous cell carcinomas2012
- Author(s)
  Imamhasan A, Mitomi H, Saito T, Hayashi T, Takahashi M, Kajiyama Y, Yao T.
- Journal Title
  
  Hum Pathol
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] Predictive value of MGMT, hMLH1, hMSH2 and BRCA1 protein expression for pathological complete response to neoadjuvant chemotherapy in basal-like breast cancer patients2011
- Author(s)
  Nakai K, Mitomi H (Equal contribution to the first author), Alkam Y, Arakawa A, Yao T, Tokuda E, Saito M, Kasumi F
- Journal Title
  
  Cancer Chemoth Pharm
  
  Volume: 69 Pages: 923-930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] Cluster analysis of claudin-1 and -4, E-cadherin, and β-catenin expression in colorectal cancers2011
- Author(s)
  Matsuoka T, Mitomi H (Equal contribution to the first author), Fukui N, Kanazawa H, Saito T, Hayashi T, Yao T
- Journal Title
  
  J.Surg.Oncol.
  
  Volume: 103 Issue: 7 Pages: 674-686
- DOI
  10.1002/jso.21854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] αvβ5 integrin promotes dedifferentiation of monolayer-cultured articular chondrocytes2011
- Author(s)
  Fukui N, Ikeda Y, Tanaka N, Wake M, Yamaguchi T, Mitomi H, Ishida S, Furukawa H, Hamada Y, Miyamoto Y, Sawabe M, Tashiro T, Katsuragawa Y, Tohma S
- Journal Title
  
  Arthritis Rheum
  
  Volume: 63(7) Pages: 1938-49
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] Cluster analysis of claudin-1 and-4, E-cadherin, andβ-catenin expression in colorectal cancers2011
- Author(s)
  Matsuoka T, Mitomi H, Fukui N, Kanazawa H, Saito T, Hayashi T, Yao T.
- Journal Title
  
  J Surg Oncol
  
  Volume: 103(7) Pages: 674-86
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] 癌併存大腸広基性鋸歯状腺腫/ポリープの臨床病理学的特徴2011
- Author(s)
  三富弘之,五十嵐誠治,伴慎一,九嶋亮治,藤田恒平,平橋美奈子,大城由美,林大久生,八尾隆史
- Journal Title
  
  胃と腸
  
  Volume: 46 Pages: 384-93
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] 大腸癌-最近の研究動向-III大腸癌の分子生物学と発癌機序発癌機序大腸鋸歯状病変の癌化2011
- Author(s)
  三富弘之,林大久生, Alkam Yimit,八尾隆史
- Journal Title
  
  日本臨床
  
  Volume: 69 Pages: 115-120
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] 大腸SSA/Pの病理組織学的特徴と診断基準大腸癌研究会プロジェクト研究から2011
- Author(s)
  八尾隆史,菅井有,岩下明徳,藤盛孝博,九嶋亮治,野首光弘,三富弘之,味岡洋一,小西文雄
- Journal Title
  
  胃と腸
  
  Volume: 46 Pages: 442-8
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] Role for p16(INK4a) in progression of gastrointestinal stromal tumors of the stomach : alteration of p16(INK4a) network members2011
- Author(s)
  Mitomi H, Fukui N, Kishimoto I, Tanabe S, Kikuchi S, Saito T, Hayashi T, Yao T.
- Journal Title
  
  Hum Pathol
  
  Volume: 42(10) Pages: 1505-13
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] Aberrant p16(INK4a)methylation is a frequent event in colorectal cancers : prognosticvalue and relation to mRNA expression and immunoreactivity2010
- Author(s)
  Mitomi H, Fukui N, et al.
- Journal Title
  
  Journal of Cancer Research and Clinical Oncology 136(2)
  
  Pages: 323-331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659360
[Journal Article] Aberrant p16^INK4a methylation is a frequent event in colorectal cancers : prognostic value and relation to mRNA expression and immunoreactivity.2010
- Author(s)
  Mitomi H, Fukui N, Tanaka N, Kanazawa H, Saito T, Matsuoka T, Yao T.
- Journal Title
  
  J Cancer Res Clin Oncol 136
  
  Pages: 323-331
- Data Source
  KAKENHI-PROJECT-20390410
[Journal Article] Changes of human menisci in osteoarthritic knee joints2010
- Author(s)
  Katsuragawa Y, Saitoh K, Tanaka N, Wake M, Ikeda Y, Furukawa H, Tohma S, Sawabe M, Ishiyama M, Yagishita S, Suzuki R, Mitomi H, Fukui N.
- Journal Title
  
  Osteoarthritis Cartilage
  
  Volume: 18(9) Pages: 1133-43
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] Changes of human menisci in osteoarthritic knee joints.2010
- Author(s)
  Katsuragawa Y, Saitoh K, Tanaka N, Wake M, Ikeda Y, Furukawa H, Tohma S, Sawabe M, Ishiyama M, Yagishita S, Suzuki R, Mitomi H, Fukui N.
- Journal Title
  
  Osteoarthritis and Cartilage 18
  
  Pages: 1133-1143
- Data Source
  KAKENHI-PROJECT-20390410
[Journal Article] Aberrant p16^<INK4a> methylation is a frequent event in colorectal cancers : prognostic value and relation to mRNA expression and immunoreactivity2010
- Author(s)
  三富弘之, 福井尚志, 田中信帆, 金澤秀紀, 齋藤剛, 松岡隆, 八尾隆史
- Journal Title
  
  J.Cancer.Res.Clin.Oncol. 136
  
  Pages: 323-331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] Aberrant p16(INK4a)methylation is a frequent event in colorectal cancers : prognostic value and relation to mRNA expression and immunoreactivity2010
- Author(s)
  Mitomi H, Fukui N, et al.
- Journal Title
  
  Journal of Cancer Research and Clinical Oncology 136(2)
  
  Pages: 323-331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390410
[Journal Article] Aberrant p16((INK4a)) methylation is a frequent event in colorectal cancers : prognostic value and relation to mRNA expression and immunoreactivity2010
- Author(s)
  Mitomi H, Fukui N, Tanaka N, Kanazawa H, Saito T, Matsuoka T, Yao T.
- Journal Title
  
  J Cancer Res Clin Oncol
  
  Volume: 136(2) Pages: 323-31
- Data Source
  KAKENHI-PROJECT-21590394
[Journal Article] Addition of an arch support improves the biomechanical effect of a laterally wedged insole.2009
- Author(s)
  Nakajima K, Kakihana W, Nakagawa T, Mitomi H, Hikita A, Suzuki R, Akai M, Iwaya T, Nakamura K, Fukui N.
- Journal Title
  
  Gait and Posture 29(2)
  
  Pages: 208-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791052
[Journal Article] Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-α.2009
- Author(s)
  Hikita A, Tanaka N, Yamane S, Ikeda Y, Furukawa H, Tohma S, Suzuki R, Tanaka S, Mitomi H, Fukui N.
- Journal Title
  
  Biocehm Cell Biol 87
  
  Pages: 581-593
- Data Source
  KAKENHI-PROJECT-20390410
[Journal Article] Addition of an arch support improves the biomechanical effect of a laterally wedged insole.2009
- Author(s)
  Nakajima K, Kakihana W, Nakagawa T, Mitomi H, Hikita A, Suzuki R, Akai M, Iwaya T, Nakamura K, Fukui N.
- Journal Title
  
  Gait and Posture 29
  
  Pages: 208-213
- Data Source
  KAKENHI-PROJECT-20390410
[Journal Article] Addition of an arch support improves the biomechanical effect of a laterally wedged insole2009
- Author(s)
  Nakajima K, Kakihana W, Nakagawa T, Mitomi H, Hikita A, Suzuki R, Akai M, Iwaya T, Nakamura K, Fukui N.
- Journal Title
  
  Gait Posture 29
  
  Pages: 208-13
- Data Source
  KAKENHI-PROJECT-19791052
[Journal Article] Zonal gene expression of chondrocytes in osteoarthritic cartilage.2008
- Author(s)
  Fukui N, Miyamoto Y, Nakajima M, Ikeda Y, Hikita A, Furukawa H, Mitomi H, Tanaka N, Katsuragawa Y, Yamamoto S, Sawabe M, Juji T, Mori T, Suzuki R, Ikegawa S.
- Journal Title
  
  Arthritis Rheum 58
  
  Pages: 3843-3853
- Data Source
  KAKENHI-PROJECT-20390410
[Journal Article] Zonal gene expression of chondrocytes in osteoarthritic cartilage.2008
- Author(s)
  Fukui N, Miyamoto Y, Nakajima M, Ikeda Y, Hikita A, Furukawa H, Mitomi H, Tanaka N, Katsuragawa Y, Yamamoto S, Sawabe M, Juji T, Mori T, Suzuki R, Ikegawa S
- Journal Title
  
  Arthritis Rheumatism 58(12)
  
  Pages: 3843-3853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791052
[Journal Article] Zonal gene expression of chondrocytes in osteoarthritis cartilage2008
- Author(s)
  Fukui N, Miyamoto M, Nakajim M, Ikeda Y, Hikita A, Furukawa H, Mitomi H, Tanaka N, Katsuragawa Y, Yamamoto S, Sawabe M, Juji T, Mori T, Suzuki R, Ikegawa S.
- Journal Title
  
  Arthritis Rheum 58
  
  Pages: 3834-53
- Data Source
  KAKENHI-PROJECT-19791052
[Journal Article] TNF-alpha induces the expression of BMP-2 through transcriptional and post-transcriptional regulatory mechanisms2006
- Author(s)
  Fukui N, Ikeda Y, Ohnuki T, Tanaka N, Hikita A, Mitomi H, Mori T, Juji T, Katsuragawa Y, Yamamoto S, Sawabe M, Yamane S, Suzuki R, Sandell LJ, Ochi T.
- Journal Title
  
  J Biol Chem 281
  
  Pages: 27229-41
- Data Source
  KAKENHI-PROJECT-19791052
[Journal Article] Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-α
- Author(s)
  Hikita A, Tanaka N, Yamane S, Ikeda Y, Furukawa H, Tohma S, Suzuki R, Tanaka S, Mitomi H, Fukui N.
- Journal Title
  
  Biochem Cell Biol (in press)
- Data Source
  KAKENHI-PROJECT-19791052
[Journal Article] Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-α
- Author(s)
  Atsuhiko Hikita, Nobuho Tanaka, Shoji Yamane, Yasuko Ikeda, Hiroshi Furukawa, Shigeto Tohma, Ryuji Suzuki, Sakae Tanaka, Hiroyuki Mitomi and Naoshi Fukui
- Journal Title
  
  Biochemistry and Cell Biology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791052
[Presentation] Pathological Features of Malignant Intraductal Papillary-Mucinous Neoplasms of the Pancreas2017
- Author(s)
  Nakahodo J, Fukumura Y, Yanai Y, Tsuyama S, Mamat O, Mitomi H, Isayama H, Kawasaki S, Yao T
- Organizer
  48th American Pancreatic Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08696
[Presentation] SSA/P併存早期大腸癌の臨床病理学的検討．2014
- Author(s)
  村上敬，三富弘之，坂本直人，立之英明，上山浩也，松本健史，澁谷智義，長田太郎,荻原達雄，寺井毅，八尾隆史，渡辺純夫
- Organizer
  第24回大腸IIc研究会
- Place of Presentation
  大阪
- Year and Date
  2014-09-14
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] 胃底腺（主細胞優位）型胃癌におけるWnt/βカテニンシグナル伝達系の変異とβカテニン核内発現との関連．2013
- Author(s)
  日高康博、三富弘之、齋藤剛、高橋路子、李世容、松本健史、八尾隆史、渡辺純夫
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] Nuclear β-catenin expression in association with mutations in components of the Wnt/β-catenin signaling pathway in gastric adenocarcinoma of fundic gland (chief cell predominant) type.2013
- Author(s)
  Hidaka Y, Mitomi H, Saito T, Takahashi M, Lee SY, Matsumoto K, Yao T, Watanabe S
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orlando, Florida, USA
- Invited
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] 虫垂原発低異型度粘液性腫瘍及び粘液性嚢胞腺腫の臨床病理学的解析．2013
- Author(s)
  原貴恵子、林大久夫、アリカムイミティ、森本崇、村上敬、李世容、日高康博、具嶋亮介、三富弘之、八尾隆史
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] Pfetin mutations at the C-terminal region define a subset of GISTs with adverse clinical outcomes.2013
- Author(s)
  大久保武人、末原義之、三富弘之、三谷恵子、高橋路子、窪田大介、近藤格、川井章、金子和夫、八尾隆史、齋藤剛
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] 大腸鋸歯状腺腫におけるHIF1α、PTCH、EphB2蛋白やDNA修復遺伝子関連蛋白発現の変化とBRAF・Kras遺伝子変異．2013
- Author(s)
  森本崇、三富弘之、齋藤剛、高橋路子、村上敬、坂本直人、八尾隆史、渡辺純夫
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] Wnt signal alteration in esophageal basaloid squamous cell carcinoma.2013
- Author(s)
  齋藤剛、三富弘之、アブドカディイマムハッサン、林大久夫、三谷恵子、高橋路子、八尾隆史
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] Immunohistochemical and oncogenetic analyses of the esophageal basaloid squamous cell carcinoma in comparison with conventional squamous cell carcinomas．2012
- Author(s)
  3) Imamhasan Abdukadir、三富弘之、齋藤剛、林大久夫、荒川敦、内田士郎、福村由紀、三谷恵子、八尾隆史
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] 胃原発のyolk sac like carcinomaの1例．2012
- Author(s)
  2) 原貴恵子、林大久夫、園上浩司、三富弘之、八尾隆史
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] 基底細胞様乳癌におけるDNA修復関連遺伝子蛋白発現の検討.2012
- Author(s)
  4) アリカムイミティ、三富弘之、中井克也、齊藤光江、霞富士雄、荒川敦、八尾隆史
- Organizer
  第20回日本乳癌学会総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] 当院におけるOSNA (One-Step Nucleic Acid Amplification) 法によるセンチネルリンパ節生検 (SNB) の検討．2012
- Author(s)
  6) 氷室貴規、三富弘之、園上浩二、堀本義哉、中井克也、齊藤光江、霞富士雄、荒川敦、八尾隆史
- Organizer
  第20回日本乳癌学会総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] Basal-like (BL) 乳癌における術前化学療法効果の検討．2012
- Author(s)
  5) 中井克也、三富弘之、アリカムイミティ、荒川敦、八尾隆史、徳田恵美、齊藤光江、霞富士雄
- Organizer
  第20回日本乳癌学会総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] 食道上皮内腫瘍におけるポリコーム蛋白EZH2, Bmi-1発現の検討2012
- Author(s)
  内田士郎、三富弘之、齋藤剛、Abdukadir Imamhasan、増田芳雄、和田了、八尾隆史
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-26
- Data Source
  KAKENHI-PROJECT-21590394
[Presentation] Immunohistochemical and oncogenetic analyses of the esophageal basaloid squamous cell carcinoma in comparison with conventional squamous cell carcinomas2012
- Author(s)
  Imamhasan Abdukadir、三富弘之、齋藤剛、林大久夫、荒川敦、内田士郎、福村由紀、三谷恵子、八尾隆史
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-27
- Data Source
  KAKENHI-PROJECT-21590394
[Presentation] 食道上皮内腫瘍におけるポリコーム蛋白EZH2，Bmi-1発現の検討．2012
- Author(s)
  1) 内田士郎、三富弘之、齋藤剛、Abdukadir Imamhasan、増田芳雄、和田了、八尾隆史
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] Luminal type乳癌の術前化学療法効果とKi67の発現．2012
- Author(s)
  7) 堀本義哉、徳田恵美、瀬沼幸司、アリカムイミティ、荒川敦、三富弘之、齊藤光江
- Organizer
  第20回日本乳癌学会総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] 巨大結腸間膜腫瘤がS状結腸に穿通した血友病患者の1例．2012
- Author(s)
  10) 高橋里奈、(他15名）、冨木裕一、坂本一博、増田芳雄、三富弘之
- Organizer
  第67回日本大腸肛門病学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] 骨軟部腫瘍におけるDNT3BのgenotypeとDNT3B蛋白発現の解析：DNT3B発現はmutator phenotypeと相関する．2012
- Author(s)
  8) 齋藤剛、三富弘之、高橋路子、大久保武人、高木辰也、鳥越知明、末原義之、金子和夫、八尾隆史
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] 側方発育型大腸腫瘍ではMUC5AC及びβカテニン発現とK-ras遺伝子が変化する．2012
- Author(s)
  9) 中江弘三郎、三富弘之、斎藤剛、高橋路子、森本崇、日高康博、坂本直人、八尾隆史、渡辺純夫
- Organizer
  第20回日本消化器関連学会週間
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590429
[Presentation] Basal-like乳癌(BL C)におけるEGER, cytokeratin(CK) 5/6/14/17, c-kit発現とclinical outcome2011
- Author(s)
  アリカムイミティ、三富弘之、中井克也、齊藤光江、霞富士雄
- Organizer
  第19回日本乳癌学会総会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21590394
[Presentation] 胃間質細胞腫瘍(GIST)におけるp16INK4a(p16)/Retinoblastoma(Rb)経路の破綻とその臨床病理学的意義2010
- Author(s)
  三富弘之、松岡隆、齋藤剛、林大久夫、八尾隆史
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590394
[Presentation] デスモイド腫瘍におけるβ-cateninの遺伝子異常のタイプと標的遺伝子の活性化能および細胞増殖能の比較検討2010
- Author(s)
  齋藤剛、三富弘之、三谷恵子、八尾隆史
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590394
[Presentation] Claudin-1, Claudin-4, E-cadherin,β-cateninの発現低下は大腸癌における予後不良因子である2010
- Author(s)
  松岡隆、三富弘之、齋藤剛、林大久夫、八尾隆史
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590394
[Presentation] インテグリンの活性抑制は変形性関節症罹患軟骨における病的コラーゲンの発現を軽減し、培養軟骨細胞の脱分化を抑制する2008
- Author(s)
  福井尚志、池田泰子、疋田温彦、三富弘之、十字琢夫、森俊仁、桂川陽三、宮本恵成、山本精三、鈴木隆二
- Organizer
  第23回日本整形外科学会基礎学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19791052
[Presentation] インテグリンの活性抑制は変形性関節症罹患軟骨における病的コラーゲンの発現を軽減し、培養軟骨細胞の脱分化を抑制する2008
- Author(s)
  福井尚志, 池田泰子, 疋田温彦, 三富弘之, 十字琢夫, ほか
- Organizer
  第23回日本整形外科学会基礎学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20390410
[Presentation] Addition of an arch support improves the biomechanical effect of a laterally wedged insole.2008
- Author(s)
  Nakajima K, Kakihana W, Nakagawa T, Mitomi H, Hikita A, Suzuki R, Akai M, Iwaya T, Nakamura K, Fukui N.
- Organizer
  2008 World Congress on Osteoarthritis.
- Place of Presentation
  Roma, Italy
- Data Source
  KAKENHI-PROJECT-20390410
[Presentation] Zonal gene expression of chondrocytes in osteoarthritis cartilage.2008
- Author(s)
  Fukui N, Miyamoto Y, Nakajim M, Ikeda Y, Hikita A, Furukawa H, Mitomi H, Tanaka N, Katsuragawa Y, Yamamoto S, Sawabe M, Juji T, Mori T, Suzuki R, Ikegawa S.
- Organizer
  2008 World Congress on Osteoarthritis.
- Place of Presentation
  Roma, Italy.
- Data Source
  KAKENHI-PROJECT-20390410
[Presentation] 変形性関節症罹患軟骨における軟骨細胞の代謝活性の検討 -マイクロアレイによる軟骨各層の遺伝子発現の解析結果から-2008
- Author(s)
  福井尚志、宮本恵成、中島正弘、池田泰子、疋田温彦、三富弘之、森俊仁、鈴木隆二、桂川陽三、山本精三、池川志郎
- Organizer
  第23回日本整形外科学会基礎学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19791052
[Presentation] Identification of possible regulatory molecules for chondrocyte anabolism in osteoarthritic cartilage2007
- Author(s)
  Fukui N, Ikeda Y, Ohnuki T, Tanaka N, Ishida S, Yamane S, Mitomi H, Hikita A, Yamamoto S, Katsuragawa Y, Suzuki R.
- Organizer
  2007 World Congress on Osteoarthritis
- Place of Presentation
  Lauderdale, FL, USA
- Data Source
  KAKENHI-PROJECT-19791052
[Presentation] Clinicopathologic characteristics and molecular associations of WNT/β-catenin signal in the serrated neoplasia pathway of the colorectum.
- Author(s)
  Murakami T, Mitomi H, Sakamoto N, Ritsuno H, Ueyama H, Matsumoto K, Shibuya T, Osada T, Yao T, Watanabe S
- Organizer
  Digestive Disease Week 2015
- Place of Presentation
  Washington DC, USA
- Year and Date
  2015-05-16 – 2015-05-19
- Data Source
  KAKENHI-PROJECT-24590429

1. FUKUI Naoshi (10251258)

# of Collaborated Projects: 4 results

# of Collaborated Products: 27 results
2. HIKITA Atuhiko (60443397)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. SUZUKI Ryuji (70373470)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
4. KANAZAWA Hideki (90265661)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. TANAKA Nobuho (60530920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. YAMANE Shoji (40419148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. FURUKAWA Hiroshi (00372293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. TOUMA Shigeto (50207528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. SAITO Tsuyoshi (80439736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
10. WATANABE Masahiko (80146604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Fukumura Yuki (90407312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 伊藤浩一 (30596119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 八尾隆史 (20243933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. IKEDA Yasuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
15. 藤盛孝博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 末原義之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Mitomi Hiroyuki 三富 弘之

MITOMI Hiroyuki 三富 弘之

Research Projects

Research Products

Co-Researchers

The relationship of microRNA expression on the signaling pathway activation in pancreatic intraductal papillary mucinous neoplasm

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MicroRNA dysregulation and signal pathway activation in ulcerative colitids-associated carcinogenesisPrincipal Investigator

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Micro RNA expression in serrated pathway and its association with a potential target therapyPrincipal Investigator

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胃底腺型胃癌におけるHedgehog/Wntシグナル伝達系の関与

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Epigenetic modification of micro RNA expression in serrated polyp-carcinoma pathwayPrincipal Investigator

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変形性関節症罹患軟骨の層間の比較によるタンパク分解酵素発現機序の解明

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Exploration of possible catabolic factors in osteoarthritis through the analysis of large numbers of human samples.

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Investigation for the mechanism of shedding for tumor necrosis factor-α and its pathological significance in rheumatoid arthritis

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Prognosis value of aberrant p16^<INK4a> gene methylation in colorectal cancer

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[Journal Article] A case of Krukenberg carcinoma metastasized from colon cancer resembling mucinous cystadenocarcinoma of the ovary2014

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[Journal Article] Distinct profile of HIF1α, PTCH, EphB2 or DNA repair protein expression and BRAF mutation in colorectal serrated adenoma.2014

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[Journal Article] Downregulation of sFRP-2 by epigenetic silencing activates the β-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma.2014

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[Journal Article] Protein expression and methylation of DNA repair genes hMLH1, hMSH2, MGMT and BRCA1 and their correlation with clinicopathological parameters and prognosis in basal-like breast cancer.2013

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[Journal Article] Alteration in the Wnt/β-catenin signaling pathway in gastric neoplasias of fundic gland (chief cell predominant) type.2013

Mitomi Hiroyuki 三富弘之

MITOMI Hiroyuki 三富弘之