NAGAI Nobutaka 永井宣隆

Researcher Number	90198292
External Links
Affiliation (based on the past Project Information) *help	2006: 広島大, 医歯(薬)学総合研究科, 助教授 2002 – 2005: 広島大学, 大学院・医歯薬学総合研究科, 助教授 1996 – 2001: 広島大学, 医学部, 助教授 1994: Hiroshima Univ.School of Medicine, Assistant Professor, 医学部, 講師 1992 – 1993: 広島大学, 医学部・附属病院, 講師 … More 1991: 広島大学, 医学部附属病院, 講師 1990: 広島大学, 医学部・附属病院, 助手 1989: 広島大学, 医学部, 附属病院助手 Less
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology
Keywords	Principal Investigator hTERT / テロメラーゼ / telomerase / ovarian cancer / 卵巣癌 / 子宮癌 / uterine cancer / p27 / p16 / GnRH … More / hTERCアンチセンス / reverse transcriptase inhibitor / アポトーシス / 婦人科癌 / neoadjubant chemotherapy / chemotherapy / apoptosis / 集学的治療 / アデノウィルスベクター / 性ステロイドホルモン / hTERアンチセンス / hTERC antisense / semiquantitation / TRAP assay / utcrinc cancer / TRAPアッセイ法 / hTERC卵巣癌 / TERCアンチセンス / 簡易定量 / TRAPアッセイ / Immuno Response / Molecular Biology / Tumor Suppressor Gene / Oncogene / Human Papillomavirus / Cervical Cancer / 子宮頸癌 / ヒトパピローマウイルス / 局所免疫応答 / 分子生物学 / 癌抑制遺伝子 / 癌遺伝子 / ヒトパピローマウィルス / 子宮頚癌 / 抗癌剤感受性試験 / 網羅的遺伝子解析 / 個別化治療 / 化学療法 … More Except Principal Investigator ヒトパピロ-マウィルス / 分子生物学 / ウィルス発癌 / ヒトピピロ-マウィルス / 子宮頸部前癌病変 / 子宮頸癌 Less

婦人科癌治療の個別化にむけたテロメラーゼ、アポトーシス制御遺伝子の網羅的解析Principal Investigator
- Principal Investigator
  
  永井宣隆
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hiroshima University
Identification of the regulatory genes of telomerase activity and apoptosis in the treatment of gynecological cancers.Principal Investigator
- Principal Investigator
  
  NAGAI Nobutaka
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hiroshima University
Molicular Biologic Study on the Regulation of Telomerase Activity and Gene Abnomality in the Development of Gynecologic CancerPrincipal Investigator
- Principal Investigator
  
  NAGAI Nobutaka
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  HIROSHIMA UNIVERSITY
Molecular biologic study of telomerase activity on carcinogenesis of uterine and ovarian cancerPrincipal Investigator
- Principal Investigator
  
  NAGAI Nobutaka
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  HIROSHIMA UNIVERSITY
Molecular Biological Study of HPV Oncogenes and Suppressor Genes in Cervical Carcino genesisPrincipal Investigator
- Principal Investigator
  
  NAGAI Nobutaka
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  HIROSHIMA UNIVERSITY
子宮頸癌・前癌病変におけるヒトパピロ-マウィルスの発癌性に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  永井宣隆, 藤原篤
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hiroshima University

All 2006 2005 2004 2003 2002

All Journal Article

[Journal Article] Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers.2006
- Author(s)
  Komatsu Masaaki.Nagai Nobutaka et al.
- Journal Title
  
  Molecular Cancer Therapeutics 25
  
  Pages: 155-155
- Data Source
  KAKENHI-PROJECT-17591742
[Journal Article] Midkine, EGFを標的としたTranscripional/Transulatioal-Dual Targeting Adenovirus Gene Therapyの試み2005
- Author(s)
  川上洋介, 永井宣隆他
- Journal Title
  
  日本婦人科腫瘍学会誌 23
  
  Pages: 225-233
- Data Source
  KAKENHI-PROJECT-17591742
[Journal Article] Relative expression levels of Th1 and Th2 cytokine mRNA are indepedent prognostic factors in patients with ovarian cancer.2005
- Author(s)
  Kusuda Tomoyo.Nagai Nobutaka et al.
- Journal Title
  
  Oncel.Rep. 13
  
  Pages: 1153-1158
- Data Source
  KAKENHI-PROJECT-17591742
[Journal Article] Predicting the chemosensitivity of ovarian and uterine cancers with the collagen gel droplet culture drug-sensitivity test.2005
- Author(s)
  Nagai Nobutaka
- Journal Title
  
  Anticancer drugs 16
  
  Pages: 525-531
- Data Source
  KAKENHI-PROJECT-17591742
[Journal Article] 不正性器出血の鑑別診断2005
- Author(s)
  永井宣隆
- Journal Title
  
  日本醫事新報 4261
  
  Pages: 12-16
- Data Source
  KAKENHI-PROJECT-17591742
[Journal Article] Villoglandular papillary adenocarcinoma of the uterine ceivix responding to neoadjuvant chemotherapy with docetaxel and cisplatin2005
- Author(s)
  Nagai Nobutaka
- Journal Title
  
  Int.J.Gynecol Cancer 15
  
  Pages: 1187-1190
- Data Source
  KAKENHI-PROJECT-17591742
[Journal Article] Expression of human kallikrein 7 and its inhibitor antileukoprotease in uterin endocervical glands and cervical adenocarcinoma2004
- Author(s)
  Tian X, Nagai N. et al.
- Journal Title
  
  Oncol.Rep. 12
  
  Pages: 1001-1006
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Expression of human kallikrein 7(hK7/SCCE)and its inhibitor anti-leukoprotease(ALP/SLPI)in uterine endocervical glands and in cervical adenocarcinomas.2004
- Author(s)
  Tian X, Shigemasa K, Hirata E, Gu L, Uebaba Y, Nagai N, O'brien TJ, Ohama K
- Journal Title
  
  Oncol.Rep. 12
  
  Pages: 1001-10067
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Human papillomavirus DNA status after loop excision for cervical intraepithelial neoplasia grade III-A prospective study2004
- Author(s)
  Nagai N et al.
- Journal Title
  
  Int. J. Mol. Med. 13
  
  Pages: 589-593
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Human papillomavirus DNA status after loop excision for cervical intraepitherial neoplasia grade III-A prospective study.2004
- Author(s)
  Nagai N et al.
- Journal Title
  
  Int.J.Mol.Med. 13
  
  Pages: 589-593
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Clinicopathological study og 56 patients with endometrial cancer during or after adjuvant tamoxifen use for their breast cancers2004
- Author(s)
  Hachisuga T, Nagai N et al.
- Journal Title
  
  Gynecol. Oncol. 95
  
  Pages: 139-144
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Expressin of human kallikrein 7 and its inhibitor antileukoprotease in uterin cervical lands and cervical adenocarcinoma2004
- Author(s)
  Tian X, Nagai N et al.
- Journal Title
  
  Oncol. Rep. 12
  
  Pages: 1001-1006
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Telomerase activation on endometrial epithelial cells by paracrine effector from stromal cells in primary cultured human endometrium2004
- Author(s)
  Oshita T, Nagai N et al.
- Journal Title
  
  Int. J. Mol. Med. 13
  
  Pages: 425-430
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Telomerase activation in endometrial cells by paracrine effectors from stromal cells in primary cultured human endometrium.2004
- Author(s)
  Oshita T, Nagai N, Mukai K, Shigemasa K, Hiura M, Ohama K
- Journal Title
  
  Int.J.Mol.Med 13
  
  Pages: 425-430
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Telomerase activation in endometrial epithelial cells by paracrine effectors from stromal cells in primary cultured human endometrium2004
- Author(s)
  Oshita T, Nagai N. et al.
- Journal Title
  
  Int.J.Mol.Med. 13
  
  Pages: 425-430
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Clinicopathological study of 56 patients with endometrial cancer during or after adiuvant tamoxifen use for their breast cancers2004
- Author(s)
  Hachisuga T, Nagai N. et al.
- Journal Title
  
  Gynecol.Oncol. 95
  
  Pages: 139-144
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Human papillamavirus DNA status after loop excision for cervical intraepithelial neoplasia grade III-A prospective study.2004
- Author(s)
  Nagai N, Mukai K, Oshita T, Shiroyama Y, Ohama K
- Journal Title
  
  INT.J.Mol.Med. 13
  
  Pages: 589-593
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Overexpression of cyclooxygenase-2 protein and its relationship to apoptosis in cervical carcinoma treated with neoadjuvant chemotherapy.2003
- Author(s)
  Nagai N, Tian X, Mukai K, Hirata E, Kusuda T, Shiroyama Y, Shigemasa K, Ohama K
- Journal Title
  
  Int.J.Mol.Med. 12
  
  Pages: 709-714
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Validation of a simple gas chromatographic-mass spectrometric method for the determination of GBL in human plasma.2003
- Author(s)
  Fukai Y, Matsushima E, Nagai N, Muramoto K, Ohama K, Yamashita K
- Journal Title
  
  J.Chromatography 785
  
  Pages: 73-80
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] p27 cyclin E and CDK2 expression in normal and cancerous endometrium.2002
- Author(s)
  Oshita T, Nagai N, Shigemasa K, Ohama K
- Journal Title
  
  Int.J.Oncol. 21
  
  Pages: 737-743
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Tumor dihydropyrimidine dehydrogenase activity in advanced cervica 1 carcinoma.2002
- Author(s)
  Mukai K, Nagai N, Shiroyama Y, Oshita T, Shigemasa K, Ohama K
- Journal Title
  
  Int.Gyn.Cancer 12
  
  Pages: 595-596
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Endometrial cytodiagnosis using a new softcyte versus a conventional endocyte.2002
- Author(s)
  Nagai N, Uebaba Y, Oshita T, Sakata K, Murakami J, Shigemasa K, Ohama K
- Journal Title
  
  Oncol.Rep. 9
  
  Pages: 483-487
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Increased MCL-1 expression is associated poor prognosis in ovarian carcinomas.2002
- Author(s)
  Shigemasa K, Shiroyama Y, Mukai K, Nagai N, Ohama K
- Journal Title
  
  Jpn.J.Cancer Res. 93
  
  Pages: 542-550
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] GnRH agonist inhibits human telomerase reverse transcriptase mRNA expression in endometrial cells.2002
- Author(s)
  Nagai N, Oshita T, Mukai K, Shiroyama Y, Shigemasa K, Ohama K
- Journal Title
  
  Int.J.Mol.Med. 10
  
  Pages: 593-597
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Tumor dihydropyrimidine dehydrogenase activity in advanced cervical carcinoma.2002
- Author(s)
  Nagai N, Shiroyama Y, Oshita T, Mukai K, Shigemasa K, Fujii T, Katube Y, Matsubayashi S, Murakami T, Ohama K
- Journal Title
  
  Oncol.Rep. 9
  
  Pages: 1033-1040
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Expression of cyclooxygenase-2 and its relationship of p53 accumulation in ovarian adenocarcinomas.2002
- Author(s)
  Shigemasa K, Tian X, Gu L, Shiroyama Y, Nagai N, Ohama K
- Journal Title
  
  Int.J.Oncol. 22
  
  Pages: 99-105
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571565
[Journal Article] Expression of matrix matelloproteinases-2 and 9 by cells isolated from the peritoneal fluid of woman with ovarian carcinomas2002
- Author(s)
  Sakata K, Shigemasa K, Uebaba Y, Nagai N, Ohama K
- Journal Title
  
  Acta Cytol. 46
  
  Pages: 697-703
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571565

1. MURAKAMI Junko (80294560)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. OTA Sanae (10243552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. SHIGEMASA Kazushi (30294557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
4. 藤原篤 (10033961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MURAKAMI Takahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 木岡寛雅

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 川上洋介

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAGAI Nobutaka 永井 宣隆

Research Projects

Research Products

Co-Researchers

婦人科癌治療の個別化にむけたテロメラーゼ、アポトーシス制御遺伝子の網羅的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of the regulatory genes of telomerase activity and apoptosis in the treatment of gynecological cancers.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molicular Biologic Study on the Regulation of Telomerase Activity and Gene Abnomality in the Development of Gynecologic CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular biologic study of telomerase activity on carcinogenesis of uterine and ovarian cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Biological Study of HPV Oncogenes and Suppressor Genes in Cervical Carcino genesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

子宮頸癌・前癌病変におけるヒトパピロ-マウィルスの発癌性に関する分子生物学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers.2006

Author(s)

Journal Title

Data Source

[Journal Article] Midkine, EGFを標的としたTranscripional/Transulatioal-Dual Targeting Adenovirus Gene Therapyの試み2005

Author(s)

Journal Title

Data Source

[Journal Article] Relative expression levels of Th1 and Th2 cytokine mRNA are indepedent prognostic factors in patients with ovarian cancer.2005

Author(s)

Journal Title

Data Source

[Journal Article] Predicting the chemosensitivity of ovarian and uterine cancers with the collagen gel droplet culture drug-sensitivity test.2005

Author(s)

Journal Title

Data Source

[Journal Article] 不正性器出血の鑑別診断2005

Author(s)

Journal Title

Data Source

[Journal Article] Villoglandular papillary adenocarcinoma of the uterine ceivix responding to neoadjuvant chemotherapy with docetaxel and cisplatin2005

Author(s)

Journal Title

Data Source

[Journal Article] Expression of human kallikrein 7 and its inhibitor antileukoprotease in uterin endocervical glands and cervical adenocarcinoma2004

Author(s)

Journal Title

Data Source

[Journal Article] Expression of human kallikrein 7(hK7/SCCE)and its inhibitor anti-leukoprotease(ALP/SLPI)in uterine endocervical glands and in cervical adenocarcinomas.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Human papillomavirus DNA status after loop excision for cervical intraepithelial neoplasia grade III-A prospective study2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Human papillomavirus DNA status after loop excision for cervical intraepitherial neoplasia grade III-A prospective study.2004

Author(s)

NAGAI Nobutaka 永井宣隆