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YOKOYAMA CHIEKO  横山 知永子

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YOKOYAMA Chieko  横山 知永子

YOKOYAMA Chikeo  横山 知永子

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Researcher Number 90200914
External Links
Affiliation (based on the past Project Information) *help 2020 – 2023: 神奈川工科大学, 健康医療科学部, 教授
2017 – 2020: 神奈川工科大学, 応用バイオ科学部, 教授
2010: 東京医科歯科大学, COE特任教授
2009: 医科歯科大, 歯学部
2008: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 非常勤講師 … More
2007: Tokyo Medical and Dental University, Graduate SchoolDepartment of Cellular Physiological Chemistry, COE program Research Professor
2007: Tokyo Medical and Dental University, 大学院・医歯薬学総合研究科, COE抛点形成特任教員
2006: 東京医科歯科大学, 大学院医歯学総合研究科, COE拠点形成特任教員
1994 – 2003: National Cardiovascular Center Research Institute, Director, 薬理部, 室長
1993: 国立循環器病センター研究所, 薬理部, 室員
1991: National Cardiovascular Center Research Institute, Department of Pharmacology, R, 薬理部, 室員
1990: 国立循環器病センター研究所, 薬理部, 研究員
1989: National Cardiovascular Center Research Institute, Department of Parmacology, Re, 薬理部, 室員
1988: 国立循環器病センター, 研究所・共通実験室, 室員 Less
Review Section/Research Field
Principal Investigator
General medical chemistry / Pathobiological dentistry/Dental radiology / Basic Section 38050:Food sciences-related / Eating habits / Pathological medical chemistry
Except Principal Investigator
General medical chemistry / Pathological medical chemistry / Obstetrics and gynecology / Functional biochemistry / Morphological basic dentistry
Keywords
Principal Investigator
プロスタサイクリン / プロスタサイクリン合成酵素 / プロスタグランジン / prostacyclin / 炎症 / ノックアウトマウス / ヒト遺伝子 / 不飽和脂肪酸 / 腎障害 / PGI2 … More / kidney / 腎臓 / PPAR-delta / prostacyclin synthase / 血管障害 / 骨 / トロンボキサンA_2 / トロンボキサン合成酵素 / プロスタグランジンI_2 / プロスタサイクリン欠損マウス / 血管内皮細胞 / PGI_2 / 多価不飽和脂肪酸 / プロスタグランジンI2 / 生理活性脂質 / 栄養学 / 慢性腎臓病 / 腎血管障害 / bone / vascular disorders / inflammation / prostaglandih / arteriosclerosis / vascular endothelial cells / knockout mice / prostaglandin / 血管 / Egr-1 / プロスタグランジンE合成酵素(6) / PPARδ / プロスタサイクリン合成酵素(3) / サイトカイン / 動脈硬化 / vascular smooth muscle cells / gene targeting mice / thromboxane synthase / thromboxane A_2 / 血管平滑筋 / 遺伝子欠損マウス / プロスタノイド受容体 / 遺伝子治療 / in situ ハイブリダイゼーション / cyclic strain / プロモーター活性 / cyclic AMP response element(CRE) / U937細胞 / 転写調節 / シクロオキシナーゼ-2 / プロスタグランジンエンドペルオキシド合成酵素-2 … More
Except Principal Investigator
プロスタグランジン / アラキドン酸 / プロスタサイクリン / トロンボキサン / シクロオキシゲナーゼ / Prostaglandin / mRNA / cyclooxygenase / prostaglandin / 構造 / シクロオキシゲナーゼ-2 / 生合成 / Prostacyclin / アセチルCoAカルボキシラーゼ / 発現 / Cyclooxygenase / Acetyl-CoA carboxylase / Arachidonic acid / 脂肪酸生合成 / トロンボキサン合成酵素 / アセチルCoAカルボキシラ-ゼ / 脂肪酸 / 肺高血圧 / PPARδ / Biotin / Metabolic regulation / Fatty acid biosynthesis / 代謝調節調節 / メッセンジャ-RNA / ビオチン / 代謝調節 / fetal membrane / stretch / estrogen / myometrium / pregnancy / 卵膜 / 伸展刺激 / エストロゲン / 子宮筋 / 妊娠 / Gene therapy / Pulmonary hypertension / PRARδ / プロスタグランジンE / ノックアウトマウス / 遺伝子治療 / inhibitor / prostaglandins / inflammation / phospholipase AィイD22ィエD2 / arachidonic acid / cycloxygenase-2 / Isozyme / ホスホリパーゼ A_2 / ホスホリパーゼA_2 / 抗炎症薬 / 炎症 / ホスホリパーゼA2 / アイソザイム / atherosclerosis / transcription / biosynthesis / prostacyclin / glucocorticoid / 分子生物学 / プロスタサイクリン合成酵素 / 動脈硬化 / 転写調節 / グルココルチコイド / シクロキシゲナーゼ / Expression / Gene / Metabolism / Fatty Acid / ジクロオキシゲナーゼ / 遺伝子 / 代謝 / 12-Lipoxygenase / Thromboxane synthase / Fatty acid / 12ーリボキシゲナ-ゼ / 12ーリポキシゲナ-ゼ / シクロオキシゲナ-ゼ / CD11b / 接着分子 / 破骨細胞分化 / 破骨細胞前駆細胞 / RAW細胞 / ギャップジャンクション / ギャップジンクション / cAMP / コネキシン43 / 破骨細胞 / 骨細胞 / 骨芽細胞 / 肺高血圧症 / アポトーシス Less
  • Research Projects

    (19 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (26 People)
  •  Approach to prevention and improvement of chronic kidney disease-like vascular disorders caused by prostacyclin deficiencyPrincipal Investigator

    • Principal Investigator
      Yokoyama Chieko
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38050:Food sciences-related
    • Research Institution
      Kanagawa Institute of Technology
  •  Elucidation of the pathogenesis of renal angiopathy due to prostacyclin deficiency and approaches to improvement and preventionPrincipal Investigator

    • Principal Investigator
      YOKOYAMA CHIEKO
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Eating habits
    • Research Institution
      Kanagawa Institute of Technology
  •  Spatiotemporal analysis of osteoclastogenesis during bone remodeling

    • Principal Investigator
      NAKAHAMA Kenichi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Tokyo Medical and Dental University
  •  炎症および骨代謝におけるプロスタサイクリンの役割と作用機序の解明Principal Investigator

    • Principal Investigator
      横山 知永子
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Tokyo Medical and Dental University
  •  The studies on the role of prostacyckin in inflammation and on its mechanism of action.Principal Investigator

    • Principal Investigator
      YOKOYAMA Chieko
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Tokyo Medical and Dental University
  •  Studies onfanction of prostacyclin and thromboxane in vascular disordersPrincipal Investigator

    • Principal Investigator
      YOKOYAMA Chieko
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Molecular Bidogical Analysis of Prostaglandin Synthesis in The Pregnant Myometrium and Fetal Membrane

    • Principal Investigator
      ITOH Hiroaki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      KYOTO UNIVERSITY
  •  プロスタサイクリンの新しいシグナル伝達系の解明と遺伝子治療への応用

    • Principal Investigator
      田邉 忠
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Study on Physiological Functions of Synthetic Enzymes for Prostaglandins by Genetically Engineered Mice

    • Principal Investigator
      TANABE Tadashi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Study on Cyclooxygenase Isozymes for Development of Anti-inflammatory Drugs

    • Principal Investigator
      TANABE Tadashi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  プロスタサイクリン及びトロンボキサン受容体の生体内機能解析Principal Investigator

    • Principal Investigator
      横山 知永子
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Studies on the regulation of biosynthesis of prostacyclin and thromboxane A_2 and search of their new biological activities.Principal Investigator

    • Principal Investigator
      YOKOYAMA Chieko
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  循環器疾患におけるプロスタサイクリン合成酵素の役割の解明Principal Investigator

    • Principal Investigator
      横山 知永子
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Molecular biological study on biosynthesis of prostglandins and thromboxane

    • Principal Investigator
      TANABE Tadashi
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  プロスタサイクリン合成酵素ヒト遺伝子の構造と発現調節機構の解明Principal Investigator

    • Principal Investigator
      横山 知永子
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  プロスタグランジンエンドペルオキシド合成酵素-2の遺伝子発現調節機構の解明Principal Investigator

    • Principal Investigator
      横山 知永子
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Molecular Biological Study on the Regulation of Metabolism of Fatty Acid and its Derivatives

    • Principal Investigator
      TANABE Tadashi
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Molecular Biological Study on the Regulation of the Lipid Metabolism

    • Principal Investigator
      TANABE Tadashi
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institue
  •  Molecular biological study on the regulation of fatty acid biosynthesis

    • Principal Investigator
      TANABE Tadashi
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institute

All 2007

All Journal Article

  • [Journal Article] 腎・心血管系におけるCOX-2の作用2007

    • Author(s)
      横山知永子, 他
    • Journal Title

      治療学 41

      Pages: 1263-1272

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18592060
  • [Journal Article] Effects of COX-2 in kidney and vascular systems. (Japanese)2007

    • Author(s)
      Yokoyama, C., et. al.
    • Journal Title

      Biomedicene and Therapeutics 41

      Pages: 1263-1272

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18592060
  • 1.  TANABE Tadashi (60025624)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 2.  HATAE Toshihisa (10251026)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  SHIMONISHI Manabu (70300978)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  INOUE Hiroyasu (40183743)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  NAKAHAMA Kenichi (60281515)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  MORITA Ikuo (60100129)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  IHARA Hayato (00223298)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  MIYATA Atsuro (60183969)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  SATO Takahiro (20397003)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  ICHINOSE Shizuko (60015146)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  AKIYAMA Masako (30436646)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HARA Shuntaro (50222229)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  MURAKAMI Makoto (60276607)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  MUROTA Sei-itsu (50072989)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  YAMAMOTO Kei (30304504)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  ITOH Hiroaki (70263085)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  FUJII Shingo (30135579)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  SAGAWA Norimasa (00162321)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  NARABA Hiroaki (90296517)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  TAKAI Toshiyuki (20187917)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  市野瀬 志津子 (60014156)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  山本 尚三 (50025607)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  奈良場 博昭 (13771443)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  ASHIDA Yasuko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  IMADA Masaru
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  今田 勝
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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