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Hijikata Makoto  土方 誠

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… Alternative Names

Hjijikata Makoto  土方 誠

HIJIKATA Makoto  土方 誠

IJIKATA Makoto  土方 誠

土方 誠  ヒジカタ マコト

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Researcher Number 90202275
Other IDs
External Links
Affiliation (Current) 2025: 公益財団法人広島生命科学研究所(研究部門), 研究部門, 主任研究員
Affiliation (based on the past Project Information) *help 2016 – 2017: 京都大学, ウイルス・再生医科学研究所, 准教授
2015: 京都大学, ウイルス研究所, 准教授
2012 – 2013: 京都大学, ウイルス研究所, 准教授
2007 – 2008: 京都大学, ウィルス研究所, 准教授
2007 – 2008: Kyoto University, ウイルス研究所, 准教授 … More
2004 – 2005: 京都大学, ウイルス研究所, 助教授
1997 – 2002: 京都大学, ウイルス研究所, 助教授
1993: 国立がんセンター, 研究所・ウイルス部, 研究員 Less
Review Section/Research Field
Principal Investigator
Virology / Virology / General medical chemistry
Except Principal Investigator
General surgery
Keywords
Principal Investigator
C型肝炎ウイルス / 肝炎 / NF-κB / hepatocellular carcinoma / hepatitis / hepatitis C virus / 持続感染 / 肝臓がん / replicon / レプリコン … More / Sp110b / Elk1 / apoptosis / persistent infection / アポトーシス / コアタンパク質 / ウイルス / 感染性粒子 / 遺伝子発現 / TXAS / トロンボキサン / 粒子形成 / HCV / 培養細胞 / 感染性 / 阻害剤 / トロンボキサン合成酵素 / アラキドン酸カスケード / 感染性粒子産生 / replication complex / RNA genome replication / 複製複合体 / RNAゲノム複製 / transcriptional cofactor / retinoic acid / chronic infection / hapatitis C virus / Two Hybrid法 / ゲノム複製 / 転写コファクター / レチノイン酸レセプター / タンパク質間相互作用 / Two Hybrid / 肝癌 / 転写補助因子 / レチノイン酸 / MAP kinase / 粗面小胞体 / ウイルス持続感染 / 細胞増殖 / MAPK / MAPキナーゼ / polypyrimidine tract binding protein / transfomation / NF-kappaB / ポリピリミジン配列結合タンパク質 / 形質転換 / NF-kB / ウイルス感染 / 肝細胞分化 / 幹細胞 / ヒト肝細胞 / インターフェロン / 自然免疫 / 肝分化 / 肝幹細胞 / ウイルス粒子 / 感染 / 宿主因子 / siRNA / 組換え体 / アミノ酸変異 / 組み換え体 / 脂肪滴 / 粒子産生 / プロテイナーゼ … More
Except Principal Investigator
移植後肝炎再発 / ステロイド / CD45 / Tリンパ球 / 免疫抑制療法 / 拒絶反応 / 生体肝移植 / C型肝炎 / 移植外科学 Less
  • Research Projects

    (9 results)
  • Research Products

    (38 results)
  • Co-Researchers

    (6 People)
  •  Study on the regulatory mechanisms of infectious particle formation of hepatitis C virus by arachidonic acid cascadePrincipal Investigator

    • Principal Investigator
      Hjijikata Makoto
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Kyoto University
  •  Study on the infection and proliferation of HCV during hepatic differentiation of human hepatic stem cellsPrincipal Investigator

    • Principal Investigator
      HIJIKATA Makoto
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Virology
    • Research Institution
      Kyoto University
  •  Immunosuppression and strategies for prevention of HCV recurrence after liver transplantation based on preoperative T cell subset analysis

    • Principal Investigator
      TAKADA Yasutsugu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Kyoto University
  •  Study on the molecular mechanisms of hepatitis C viral particle productionPrincipal Investigator

    • Principal Investigator
      HIJIKATA Makoto
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Kyoto University
  •  Structural and functional studies on replication complex for hepatitis C viral genomePrincipal Investigator

    • Principal Investigator
      HIJIKATA Makoto
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      KYOTO UNIVERSITY
  •  Study for mechanisms of NF-κB activation by hepatitis C viral core proteinPrincipal Investigator

    • Principal Investigator
      HIJIKATA Makoto
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      KYOTO UNIVERSITY
  •  THE MECHANISMS OF ANTI-APOPTOTIC EFFECTS BY HEPATITIS C VIRUS CORE PROTEINPrincipal Investigator

    • Principal Investigator
      HIJIKATA Makoto
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      KYOTO UNIVERSITY
  •  THE MECHANISMS OF CELL TRANSFORMATION INDUCED BY HEPATITIS CVIRUSPrincipal Investigator

    • Principal Investigator
      HIJIKATA Makoto
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      KYOTO UNIVERSITY
  •  C型肝炎ウイルスプロテイナーゼ1(Cpro-1)の性状解析Principal Investigator

    • Principal Investigator
      土方 誠
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General medical chemistry
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

All 2017 2016 2014 2013 2009 2008 2007 2005

All Journal Article Presentation Patent

  • [Journal Article] Broad-spectrum antiviral agents: secreted phospholipase A2 targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane2017

    • Author(s)
      Ming Chen, Chie Aoki-Utsubo, Masanori Kameoka, Lin Deng, Yutaka Terada, Wataru Kamitani, Kei Sato, Yoshio Koyanagi, Makoto Hijikata, Keiko Shindo, Takeshi Noda, Michinori Kohara & Hak Hotta.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 15931-15931

    • DOI

      10.1038/s41598-017-16130-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05813, KAKENHI-PROJECT-16H05826, KAKENHI-PROJECT-15K08495, KAKENHI-PROJECT-15H04739
  • [Journal Article] Liver-specific mono-unsaturated fatty acid synthase-1 inhibitor for anti-hepatitis C treatment2016

    • Author(s)
      Nio Y., Hasegawa H., Okamura H., Miyayama Y., Akahori Y., Hijikata M.
    • Journal Title

      Antiviral Research

      Volume: 132 Pages: 262-267

    • DOI

      10.1016/j.antiviral.2016.07.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08495
  • [Journal Article] Critical role of interferon-alpha constitutively produced in human hepatocytes in response to RNA virus infection2014

    • Author(s)
      Yoji Tsugawa, Hiroki Kato, Takashi Fujita, Kunitada Shimotohno, Makoto Hijikata
    • Journal Title

      PLoS ONE

      Volume: 9

    • Data Source
      KAKENHI-PROJECT-24659205
  • [Journal Article] Critical role of interferon-α constitutively produced in human hepatocytes in response to RNA virus infection.2014

    • Author(s)
      Tsugawa Y, Kato H, Fujita T, Shimotohno K, Hijikata M.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 2 Pages: e89869-e89869

    • DOI

      10.1371/journal.pone.0089869

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22114004, KAKENHI-PROJECT-24659205
  • [Journal Article] 3D cultured immortalized human hepatocytes useful to develop drugs for blood-borne HCV2009

    • Author(s)
      Hussein H. Aly, Kunitada Shimotohno, Makoto Hijikata
    • Journal Title

      Biochem. Biophys. Res. Commun 379巻

      Pages: 330-334

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Journal Article] 3D cultured immortalized human hepatocytes useful to develop drugs for blood-borne HCV2009

    • Author(s)
      Hussein H. Aly, Kunitada Shimotohno, Makoto Hijikata
    • Journal Title

      Biochem. Biophys. Res. Commun. 379

      Pages: 330-334

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Journal Article] TORC 2, a coactivator of CREB, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein2009

    • Author(s)
      Takayuki Murata, Yoshitaka Sato, Sanae Nakayama, Ayumi Kudoh, Satoko Iwahori, Hiroki Isomura, Masako Tajima, Takayuki Hishiki, Takayuki Ohshima, Makoto Hijikata, Kunitada Shimotohno, Tatsuya Tsururmi
    • Journal Title

      J. Biol. Chem. 284

      Pages: 8033-8041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Journal Article] C型肝炎ウイルスの生活環と発がん2008

    • Author(s)
      宮成悠介, 臼田信光, 土方誠, 下遠野邦忠
    • Journal Title

      化学と生物 46

      Pages: 826-831

    • NAID

      10024938882

    • Data Source
      KAKENHI-PROJECT-19590472
  • [Journal Article] HTLV-1 HBZ Protein bypasses the targeting function of ubiquitination2008

    • Author(s)
      Osamu Isono, Takayuki Ohshima, Yasushi Saeki, Jun Matsumoto, Makoto Hijikata, Keiji Tanaka, Kunitada Shimotohno
    • Journal Title

      J. Biol Chem. 283

      Pages: 34273-34282

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Journal Article] 3D細胞培養系を用いた患者血液由来HCV培養2008

    • Author(s)
      土方誠, アリ・ハッサン・フセイン, 下遠野邦忠
    • Journal Title

      肝・胆・膵 57巻

      Pages: 679-687

    • Data Source
      KAKENHI-PROJECT-19590472
  • [Journal Article] HCVと肝発癌2008

    • Author(s)
      土方誠
    • Journal Title

      医学のあゆみ 224巻

      Pages: 693-698

    • Data Source
      KAKENHI-PROJECT-19590472
  • [Journal Article] 3D細胞培養系を用いた患者血液由来HCV培養2008

    • Author(s)
      土方誠, アリ・ハッサン・フセイン, 下遠野邦忠
    • Journal Title

      肝・胆・膵 57

      Pages: 679-687

    • Data Source
      KAKENHI-PROJECT-19590472
  • [Journal Article] HCVと肝発癌2008

    • Author(s)
      土方誠
    • Journal Title

      医学のあゆみ 224

      Pages: 693-698

    • Data Source
      KAKENHI-PROJECT-19590472
  • [Journal Article] Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner2008

    • Author(s)
      Akio Iwai, Makoto Hijikata, Takayuki, Hishiki, Osamu Isono, Tsutomu Chiba, Kunitada Shimotohno
    • Journal Title

      oncogene 27

      Pages: 1520-1526

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Journal Article] The lipid droplet is an important organelle for hepatitis C virus production.2007

    • Author(s)
      Miyanari Y., Atsuzawa K., Usuda N., Watashi K., Hishiki T., Zayas M., Bartenschlager R., Wakita T., Hijikata M., Shimotohno K.
    • Journal Title

      Nature Cell Biology 9

      Pages: 1089-1097

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Journal Article] Enhancement of internal ribosome entry site mediated translation and replication of hapatitis C virus by PD980592005

    • Author(s)
      T.Murata, M.Hijikata, K.Shimotohno
    • Journal Title

      Virology 340

      Pages: 105-115

    • Data Source
      KAKENHI-PROJECT-16590384
  • [Journal Article] Cyclosphilin Bis functional regulator of hepatitis C virus RNA polymerase2005

    • Author(s)
      K.Watashi, N.Ishii, M.Hijikata, D.Inoue, T.Murata, Y.Miyanari, K.Shimotohno
    • Journal Title

      Molecular Cell 19・1

      Pages: 111-122

    • Data Source
      KAKENHI-PROJECT-16590384
  • [Journal Article] Suppression of hepatitis C virus replicon by TGF-beta2005

    • Author(s)
      T.Murata, T.Ohshima, M.Yamaji, M.Hosaka, Y.Miyanari M.Hijikata, K.Shimotohno
    • Journal Title

      Virology 331・2

      Pages: 407-417

    • Data Source
      KAKENHI-PROJECT-16590384
  • [Patent] C肝炎ウイルスの感染増殖性の評価方法、およびその利用2008

    • Inventor(s)
      土方誠、山口逹哉、アリハッサンフセイン
    • Industrial Property Rights Holder
      土方誠、山口逹哉、アリハッサンフセイン
    • Industrial Property Number
      2008-167943
    • Filing Date
      2008-06-26
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Patent] C肝炎ウイルスの感染増殖性の評価方法、およびその利用2008

    • Inventor(s)
      土方誠, 山口達哉, アリハッサン フセイン
    • Industrial Property Rights Holder
      土方誠, 山口達哉, アリハッサン フセイン
    • Industrial Property Number
      2008-167943
    • Filing Date
      2008-06-26
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Patent] 感染性C肝炎ウイルス粒子の製造方法、およびその利用2008

    • Inventor(s)
      土方誠、山口逹哉、アリハッサンフセイン
    • Industrial Property Rights Holder
      土方誠、山口逹哉、アリハッサンフセイン
    • Industrial Property Number
      2008-167942
    • Filing Date
      2008-06-26
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Patent] 肝炎ウイルスの増殖方法、及び肝炎ウイルス感染細胞を培養するための中空糸並びにその利用2008

    • Inventor(s)
      山口逹哉、瀬川昌也、溝上雅史、田中靖人、下遠野邦忠、土方誠
    • Industrial Property Rights Holder
      山口逹哉、瀬川昌也、溝上雅史、田中靖人、下遠野邦忠、土方誠
    • Filing Date
      2008-04-03
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Patent] 肝炎ウイルスの増殖方法、及び肝炎ウイルス感染細胞を培養するための中空糸並びにその利用2008

    • Inventor(s)
      山口達哉, 瀬川昌也, 溝上雅史, 田中靖人, 下遠野邦忠, 土方誠
    • Industrial Property Rights Holder
      山口達哉, 瀬川昌也, 溝上雅史, 田中靖人, 下遠野邦忠, 土方誠
    • Acquisition Date
      2008-04-03
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Patent] 感染性C肝炎ウイルス粒子の製造方法、およびその利用2008

    • Inventor(s)
      土方誠, 山口達哉, アリハッサン フセイン
    • Industrial Property Rights Holder
      土方誠, 山口達哉, アリハッサン フセイン
    • Industrial Property Number
      2008-167942
    • Filing Date
      2008-06-26
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Presentation] Development of novel recombinant HCV1b culture system.2017

    • Author(s)
      Miyayama Y., Chayama H., Miki D., Imamura M., Chayama K., Hijikata M.
    • Organizer
      第65回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K08495
  • [Presentation] Liver-specific mono-unsaturated fatty acid synthase-1 inhibitor as one option for anti-hepatitis C treatment2016

    • Author(s)
      Hasegawa H., Nio Y., Okamura H., Miyayama Y., Akahori Y., Hijikata M.
    • Organizer
      23th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Kyopto Japan
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08495
  • [Presentation] C型肝炎治療薬の新たな分子標的の探索2013

    • Author(s)
      土方誠
    • Organizer
      第13回肝疾患フォーラム学術集会基調講演
    • Place of Presentation
      大阪
    • Year and Date
      2013-11-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659205
  • [Presentation] Type I and type III interferon play anti-viral roles cooperatively in human hepatocytes to prevent early infection spread of vitruses2013

    • Author(s)
      Yoji Tsugawa, Hiroki Kato, Takashi Fujita, Kunitada Shimotohno, Makoto Hijikata
    • Organizer
      20^<th> International symposium on hepatitis C virus and related viruses(6^<th>-10^<th>)
    • Place of Presentation
      Melbourne, Australia
    • Data Source
      KAKENHI-PROJECT-24659205
  • [Presentation] C型肝炎治療薬の新たな分子標的の探索2013

    • Author(s)
      土方誠
    • Organizer
      第13回肝疾患フォーラム学術集会 基調講演
    • Place of Presentation
      大阪
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659205
  • [Presentation] ヒト肝細胞の抗ウイルス初期応答においてI型およびIII型インターフェロンは協調的に作用する2013

    • Author(s)
      津川陽司、加藤博己、藤田尚志、下遠野邦忠、土方誠
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24659205
  • [Presentation] Type I and type III interferon play anti-viral roles cooperatively in human hepatocytes to prevent early infection spread of viruses.2013

    • Author(s)
      Tsugawa Y., Kato H., Fujita T., Shimotohno T., Hijikata M.
    • Organizer
      20th International symposium on hepatitis C virus and related viruses
    • Place of Presentation
      Melbourne, Australia
    • Data Source
      KAKENHI-PROJECT-24659205
  • [Presentation] A prolonged culture system for the study of the entire life cycle and the pathogenesis of natural HCV infection2008

    • Author(s)
      Hussein H Aly, Yue Qi, Kunitada Shimotohno, Makoto Hijikata
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Presentation] SERUM DERIVED HCV INFECTION, REPICATION AND PARTICLE PRODUCTION IN IMMORTALIZED PRIMARY HUMAN HEPATOCYTES2008

    • Author(s)
      Hussein H Aly, Kunitada Shimotohno, Makoto Hijikata
    • Organizer
      XIV. Internationsl Congress of Virology
    • Place of Presentation
      Istanbul
    • Year and Date
      2008-08-12
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Presentation] SERUM DERIVED HCV INFECTION, REPICATION AND PARTICLE PRODUCTION IN IMMORTALIZED PRIMARY HUMAN HEPATOCYTES、XIV2008

    • Author(s)
      Hussein H Aly, Kunitada Shimotohno, Makoto Hijikata
    • Organizer
      International Congress of Virology
    • Place of Presentation
      Istanbul
    • Year and Date
      2008-08-12
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Presentation] Development of the novel in vitro system supporting the entire life cycle of natural HCV2008

    • Author(s)
      Hussein H Aly, Tatsuya Yamaguchi, Yue Qi, Kunitada Shimotohno, Makoto Hijikata
    • Organizer
      15th International Symposium Hepatitis C Virus & Related Viruses
    • Place of Presentation
      San Antonio
    • Year and Date
      2008-10-07
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Presentation] 不死化肝細胞の中空糸培養によって再現した患者血清由来天然HCVの感染増殖2008

    • Author(s)
      アリフセイン, 斉月, 山口達哉, 下遠野邦忠, 土方誠
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2008-10-26
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Presentation] Development of the novel in vitro system supporting the entire life cycle of natura HCV2008

    • Author(s)
      Hussein H Aly, Tatsuya Yamaguchi, Yue Qi, Kunitada Shimotohno, Makoto Hijikata
    • Organizer
      15th International Symposium Hepatitis C Virus & Related Viruses
    • Place of Presentation
      San Antonio
    • Year and Date
      2008-10-07
    • Data Source
      KAKENHI-PROJECT-19590472
  • [Presentation] C型肝炎ウイルス(HCV)粒子産生と脂肪小滴2007

    • Author(s)
      宮成悠介、厚沢季美江、臼田信光、土方誠、下遠野邦忠
    • Organizer
      第30回日本分子生物学会年会/第80回日本生化学会大会(合同大会)
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2007-12-15
    • Data Source
      KAKENHI-PROJECT-19590472
  • 1.  HAGA Hironori (10252462)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  UEDA Yoshihide (90378662)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  EGAWA Hiroto (40293865)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  TAKADA Yasutsugu (10272197)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  下遠野 邦忠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  佐藤 佳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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