Kaji Toshiyuki 鍜冶利幸

… Alternative Names

KAJI Toshiyuki 鍜冶利幸

鍛治利幸カジトシユキ

鍜治利幸カジ

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Researcher Number	90204388
Other IDs
Affiliation (Current)	2025: 東京理科大学, 薬学部薬学科, 教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 東京理科大学, 薬学部薬学科, 教授 2016 – 2017: 東京理科大学, 薬学部薬学科, 教授 2012 – 2015: 東京理科大学, 薬学部, 教授 2003 – 2009: Hokuriku University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 2002 – 2003: 北陸大学, 薬学部, 助教授 … More 1997 – 2000: 北陸大学, 薬学部, 助教授 1995 – 1996: 北陸大学, 薬学部, 講師 1992 – 1993: 北陸大学, 薬学部, 講師 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Environmental pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Environmental and hygienic pharmacy / Biological pharmacy Except Principal Investigator Environmental and hygienic pharmacy
Keywords	Principal Investigator プロテオグリカン / 血管内皮細胞 / 血管 / 周皮細胞 / ビグリカン / パールカン / グリコサミノグリカン / Proteoglycan / デコリン / バイオオルガノメタリクス … More / 内皮細胞 / コア蛋白 / ヘパラン硫酸 / 有機-無機ハイブリッド分子 / Glycosaminoglycan / Pericyte / Endothelial cell / デルマタン硫酸 / CTGF / 細胞増殖因子 / Vascular / Perlecan / メタロチオネイン / TGF-β / 細胞毒性 / 毒性 / 銅錯体 / 小胞体ストレス / 鉛 / 重金属 / 活性イオウ分子産生酵素 / 動脈硬化 / 細胞内シグナル経路 / FGF-2 / 活性イオウ分子 / 有機－無機ハイブリッド分子 / 誘導 / Dermatan sulfate / Chondroitin sulfate / Heparan sulfate / コンドロイチン硫酸 / Vascular endothelial growth factor / Syndecan-1 / Microvasculature / 脳微小血管 / シンデカン / 血管内皮増殖因子 / シンデカン-1 / 微小血管 / vascular / extracellular matrix / biglycan / decorin / growth factor / proteoglycan / vascular endothelial cell / トランスフォーミング増殖因子 / VEGF / 細胞外マトリックス / Core protein / Decorin / Biglycan / Versican / Pericytes / バーシカン / 有害化学物質 / 分子標的 / 金属毒性学 / 有機テルル化合物 / 有機金属化合物 / ハイブリッド分子 / 生理活性 / 金属生物学 / 毒性学 / トランスポーター / 整理活性 / 生体分子 / 血管平滑筋細胞 / サイトカイン / 亜鉛輸送体 / カドミウム / 亜鉛 / 金属輸送体 / 神経細胞 / 脳 / メチル水銀 / 増殖 / TGFβ / 塩基性線維芽細胞増殖因子 / プロテインキナーゼC / サイクリックAMP … More Except Principal Investigator 環日本海 / 西高東低 / 土壌 / 黄砂 / 硫酸イオン / 酸性雨・雪 / パールカン / バイオオルガノメタリクス / 血管内皮細胞 / プロテオグリカン / cation exchange reaction / X band-radar / Kosa / dissolution of carbonate / river water quality / soil acidification / action of aluminum / SO_4^<2-> concentration / Japan-Sea coast / 硫黄の安定同位体比 / 環境影響 / アジェンダ21 / 積雪の鉛直断面 / 融雪水 / アニオン成分 / 日本海側 / 降雪雪片 / 四川省 / 酸性雨 / 大連経済技術開発区 / 図們江 / 土壌・森林 / 吉林省 / 黄砂現象 / 降雪粒子 / International Symposium on the Air Pollution Control Policy and Strategy Chongqing '92 / Chongqing / Japan-Sea rim / atmospheric pressure arrangement / soil / Kosa (yellow sand) / sulfuric ion / rain, acid ; rain, snow / 汚染物質 / 降雨・雪 / 冬季 / 東アジア / 中国・重慶 / 長距離輸送 / 大気汚染物質 / 環日本海域 / 中日大気汚染防止対策シンポジウム-重慶′92 / 重慶 Less

Expression, functions, and synthesis regulation of reactive sulfur species in vascular endothelial cellsPrincipal Investigator
- Principal Investigator
  
  Kaji Toshiyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tokyo University of Science
Analysis of molecular mechanisms for vascular endothelial perlecan synthesis by the strategy of bio-organometallices
- Principal Investigator
  
  YAMAMOTO Chika
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Toho University
Mechanisms underlying endothelial metallothionein induction based on the strategy of bioorganometallicsPrincipal Investigator
- Principal Investigator
  
  Kaji Toshiyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Tokyo University of Science
Regulation of vascular endothelial cell functions and exhibition of heavy metal toxicity through zinc transporter expressionPrincipal Investigator
- Principal Investigator
  
  Kaji Toshiyuki
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tokyo University of Science
Molecular targets and biological systems involved in the toxicity of nucleophilic organometallic compoundsPrincipal Investigator
- Principal Investigator
  
  KAJI Toshiyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tokyo University of Science
Abnormal proteoglycan metabolism as a target of neurotoxicity of mechylmercuryPrincipal Investigator
- Principal Investigator
  
  KAJI Toshiyuki
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokuriku University
Regulation of glycosmainoglycan chain formation in proteoglycan molecules synthesized by brain vascular cellsPrincipal Investigator
- Principal Investigator
  
  KAJI Toshiyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
Characterization of proteoglycans expressed in brain vascular cells and regulation of their synthesisPrincipal Investigator
- Principal Investigator
  
  KAJI Toshiyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
細胞増殖因子による血管内皮細胞プロテオグリカン分子種の合成調節Principal Investigator
- Principal Investigator
  
  KAJI Toshiyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
Clarification of characteristics, functions and regulation of proteoglycans synthesized by pericytesPrincipal Investigator
- Principal Investigator
  
  KAJI Toshiyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
増殖制御因子による血管内皮細胞プロテオグリカン分子種の産生調節Principal Investigator
- Principal Investigator
  
  鍛冶利幸
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
血管内皮細胞プロテオグリカンの産生と放出の調節を介在する細胞内情報伝達経路Principal Investigator
- Principal Investigator
  
  鍛冶利幸
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University
Environmental Impact Assessment and Counter-plans for Acid Rain and Snow in the Circum-pan-Japan Sea Area (Japan, Korea and China)
- Principal Investigator
  
  HIRAI Eiji
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Hokuriku University
Analysis of Pollutants in Rain and Snow in the Circum-pan-Japan-Sea Area (Japan, Korea and China)
- Principal Investigator
  
  HIRAI Eiji
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Hokuriku University
  Kanazawa University

[Journal Article] Sodium trisulfide, a sulfane sulfur donor, stimulates bovine aortic endothelial cell proliferation in culture2021
- Author(s)
  Takahashi, M., Iwai, R., Takasawa, R., Nakano, T., Fujie, T., Hara, T., Hara, Y., Yamamoto, C.* and Kaji, T.*
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 7 Pages: 341-344
- DOI
  10.2131/jts.46.341
- NAID
  130008060478
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089
[Journal Article] Fibroblast Growth Factor-2 Upregulates Reactive Sulfur Species Production <i>via</i> ERK1/2 Signal-Mediated Cystathionine γ-Lyase Induction in Cultured Bovine Aortic Endothelial Cells2021
- Author(s)
  Takahashi, M., Kubota, T., Fujie, T., Shinkai, Y., Kumagai, Y., Nakano, T., Hara, T., Yamamoto, C.* and Kaji, T.*
- Journal Title
  
  BPB Reports
  
  Volume: 4 Issue: 6 Pages: 175-181
- DOI
  10.1248/bpbreports.4.6_175
- NAID
  130008115933
- ISSN
  2434-432X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-19K19418, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340
[Journal Article] Synthesis of reactive sulfur species in cultured vascular endothelial cells after exposure to TGF-β1: Induction of cystathionine γ-lyase and cystathionine β-synthase expression mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 pathways2021
- Author(s)
  37.Takahashi, M., Fujie, T., Nakano, T., Hara, T., Shinkai, Y., Takasawa, R., Hara, Y., Kumagai, Y., Yamamoto, C.* and Kaji, T.*
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 21 Pages: 11762-11762
- DOI
  10.3390/ijms222111762
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340
[Journal Article] Arsenite inhibits tissue-type plasminogen activator synthesis through NRF2 activation in cultured human vascular endothelial EA.hy926 cells2021
- Author(s)
  Tsuyoshi Nakano, Tsutomu Takahashi, Chika Yamamoto, Eiko Yoshida, Toshiyuki Kaji, and Yasuyuki Fujiwara
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 2 Pages: 739-739
- DOI
  10.3390/ijms22020739
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-20K12185
[Journal Article] Cell density-dependent fibroblast growth factor-2 signaling regulates syndecan-4 expression in cultured vascular endothelial cells2020
- Author(s)
  Takato Hara, Shiori Yabushita, Chika Yamamoto and Toshiyuki Kaji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 10 Pages: 3698-3698
- DOI
  10.3390/ijms21103698
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K19418
[Journal Article] Cell density-dependent modulation of perlecan synthesis by dichloro(2,9-dimethyl-1,10-phenanthroline)zinc(II) in vascular endothelial cells2020
- Author(s)
  Takato Hara, Sayaka Sakamaki, Atsuya Ikeda, Takehiro Nakamura, Chika Yamamoto, Toshiyuki Kaji
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 2 Pages: 109-115
- DOI
  10.2131/jts.45.109
- NAID
  130007798450
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K19418
[Journal Article] Zn(II)2,9-dimethyl-1,10-phenanthroline stimulates cultured bovine aortic endothelial cell proliferation2020
- Author(s)
  Takehiro Nakamura, Eiko Yoshida, Takato Hara, Tomoya Fujie, Chika Yamamoto, Yasuyuki Fujiwara, Fumihiko Ogata, Naohito Kawasaki, Ryo Takita, Masanobu Uchiyama and Toshiyuki Kaji
- Journal Title
  
  RSC Advances
  
  Volume: 10 Issue: 69 Pages: 42327-42337
- DOI
  10.1039/d0ra06731h
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-17H06173
[Journal Article] Induction of metallothionein isoforms in cultured bovine aortic endothelial cells exposed to cadmium2020
- Author(s)
  Tomoya Fujie, Yusuke Ozaki, Fukuta Takenaka, Misaki Nishio, Takato Hara, Yasuyuki Fujiwara, Chika Yamamoto, and Toshiyuki Kaji
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 12 Pages: 801-806
- DOI
  10.2131/jts.45.801
- NAID
  130007948808
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361
[Journal Article] Cell density-dependent accumulation of low polarity gold nanocluster in cultured vascular endothelial cells2020
- Author(s)
  Takato Hara, Misato Saeki, Yuichi Negishi, Toshiyuki Kaji, and Chika Yamamoto
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 12 Pages: 795-800
- DOI
  10.2131/jts.45.795
- NAID
  130007948829
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-20K21178
[Journal Article] Transcriptional induction of cystathionine γ-lyase, a reactive sulfur-producing enzyme, by copper diethyldithiocarbamate in cultured vascular endothelial cells2020
- Author(s)
  Tomoya Fujie, Akane Takahashi, Musubu Takahashi, Takato Hara, Asuka Soyama, Kosho Makino, Hideyo Takahashi, Chika Yamamoto, Yoshito Kumagai, Hiroshi Naka and Toshiyuki Kaji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 17 Pages: 6053-6053
- DOI
  10.3390/ijms21176053
- NAID
  120007163377
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-19K16454, KAKENHI-PROJECT-18H05293
[Journal Article] Intracellular accumulation-independent cytotoxicity of pentavalent organoantimony compounds in cultured vascular endothelial cells2019
- Author(s)
  Takato Hara, Shihoko Nakano, Yuki Kitamura, Chika Yamamoto, Shuji Yasuike, Toshiyuki Kaji
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 44 Issue: 12 Pages: 845-848
- DOI
  10.2131/jts.44.845
- NAID
  130007759779
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089
[Journal Article] Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells2019
- Author(s)
  Tomoya Fujie, Fukuta Takenaka, Eiko Yoshida, Shuji Yasuike, Yasuyuki Fujiwara, Yasuhiro Shinkai, Yoshito Kumagai, Chika Yamamoto, Toshiyuki Kaji
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 44 Issue: 5 Pages: 327-333
- DOI
  10.2131/jts.44.327
- NAID
  130007642916
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-18H05293
[Journal Article] Copper diethyldithiocarbamate as an inhibitor of tissue plasminogen activator synthesis in cultured human coronary endothelial cells2017
- Author(s)
  Fujie Tomoya、Okino Shiori、Yoshida Eiko、Yamamoto Chika、Naka Hiroshi、Kaji Toshiyuki
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 42 Issue: 5 Pages: 553-558
- DOI
  10.2131/jts.42.553
- NAID
  130006076730
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14992
[Journal Article] Synergistic cytotoxicity caused by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells2017
- Author(s)
  Nakamura T, Yoshida E, Fujie T, Ogata F, Yamamoto C, Kawasaki N, Kaji T
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 42 Issue: 6 Pages: 683-687
- DOI
  10.2131/jts.42.683
- NAID
  130006206268
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08047
[Journal Article] Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells.2016
- Author(s)
  Fujie T, Murakami M, Yoshida E, Tachinami T, Shinkai Y, Fujiwara Y, Yamamoto C, Kumagai Y, Naka H, Kaji T.
- Journal Title
  
  Journal of Biological Inorganic Chemistry
  
  Volume: 21 Issue: 2 Pages: 263-273
- DOI
  10.1007/s00775-016-1337-z
- NAID
  120007135582
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14992, KAKENHI-PROJECT-24390034
[Journal Article] Zinc diethyldithiocarbamate as an inducer of metallothionein in cultured vascular endothelial cells2016
- Author(s)
  Fujie T, Segawa Y, Uehara A, Nakamura T, Kimura T, Yoshida E, Yamamoto C, Uchiyama M, Naka H, Kaji T.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 41 Issue: 2 Pages: 217-224
- DOI
  10.2131/jts.41.217
- NAID
  130005132664
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14992, KAKENHI-PROJECT-24390034
[Journal Article] Cytotoxicity of zinc, copper and rhodium complexes with 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells2016
- Author(s)
  Hara T, Matsuzaki H, Nakamura T, Yoshida E, Ohkubo T, Maruyama H, Yamamoto C, Saito S, Kaji T.
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 3 Issue: 3 Pages: 109-113
- DOI
  10.2131/fts.3.109
- NAID
  130005151853
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08047
[Journal Article] Partial contribution of the Keap1-Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells.2016
- Author(s)
  Shinkai Y, Kimura T, Itagaki A, Yamamoto C, Taguchi K, Yamamoto M, Kumagai Y, Kaji T.
- Journal Title
  
  Toxicol Appl Pharmacol
  
  Volume: 295 Pages: 37-46
- DOI
  10.1016/j.taap.2016.01.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460384, KAKENHI-PROJECT-15K14992, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-24390034, KAKENHI-PUBLICLY-16H01190, KAKENHI-PROJECT-15KK0325
[Journal Article] Transcriptional induction of metallothionein by tris(pentafluorophenyl)stibane in cultured bovine aortic endothelial cells2016
- Author(s)
  Fujie, T., Murakami, M., Yoshida, E., Yasuike, S., Kimura, T., Fujiwara, Y., Yamamoto, C. and Kaji, T.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 17 Issue: 9 Pages: 1381-1381
- DOI
  10.3390/ijms17091381
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14992
[Journal Article] Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells2016
- Author(s)
  Fujie T, Segawa Y, Yoshida E, Kimura T, Fujiwara Y, Yamamoto C, Satoh M, Naka H, Kaji T.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 41 Issue: 2 Pages: 225-232
- DOI
  10.2131/jts.41.225
- NAID
  130005132663
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14992, KAKENHI-PROJECT-24390034
[Journal Article] Toxicology of organic-inorganic hybrid molecules: bio-organometallics and its toxicology2016
- Author(s)
  Fujie, T., Hara, T. and Kaji, T.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 41 Issue: Special Pages: SP81-SP88
- DOI
  10.2131/jts.41.SP81
- NAID
  130005450523
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14992
[Journal Article] Heparan sulfate chains potentiate cadmium cytotoxicity in cultured vascular endothelial cells.2015
- Author(s)
  Fujiwara Y, Yamamoto C, Yoshida A, Kumagai Y, Kaji T.
- Journal Title
  
  Arch Toxicol.
  
  Volume: 印刷中 Issue: 2 Pages: 259-267
- DOI
  10.1007/s00204-014-1420-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-24390034
[Journal Article] The cytotoxicity of organobismuth compounds with certain molecular structures can be diminished by replacing the bismuth atom with an antimony atom in the molecules2015
- Author(s)
  Kohri, K., Yoshida, E., Yasuike, S., Fujie, T., Yamamoto, C., Kaji, T.
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 40 Pages: 321-327
- NAID
  130005068415
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390034
[Journal Article] Comparative cytotoxicity of triphenylstibane and fluorine-substituted triarylpnictogens in cultured vascular endothelial cells2015
- Author(s)
  Murakami, M., Fujie, T., Matsumura, M., Yoshida, E., Yamamoto, C., Fujiwara, Y., Yasuike, S., Kaji, T.
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 2 Pages: 61-66
- NAID
  130005083360
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390034
[Journal Article] The cytotoxicity of organobismuth compounds with certain molecular structures can be diminished by replacing the bismuth atom with an antimony atom in the molecules2015
- Author(s)
  Kohri, K., Yoshida, E., Yasuike, S., Fujie, T., Yamamoto, C., Kaji, T.
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 3 Pages: 321-327
- NAID
  130005068415
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24659058
[Journal Article] Comparative cytotoxicity of triphenylstibane and fluorine-substituted triarylpnictogens in cultured vascular endothelial cells2015
- Author(s)
  Murakami, M., Fujie, T., Matsumura, M., Yoshida, E., Yamamoto, C., Fujiwara, Y., Yasuike, S., Kaji
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 2 Pages: 61-66
- NAID
  130005083360
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24659058
[Journal Article] Convenient method to assess chemical modification of protein thiols by I electronhilic metals2014
- Author(s)
  Toyama T, Shinkai Y, Yazawa A, Kakehashi H, Kaji T and Kumagai Y.
- Journal Title
  
  Chem Biol Interact
  
  Volume: (In press) Pages: 41-48
- DOI
  10.1016/j.cbi.2014.02.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-24390034, KAKENHI-PROJECT-24659058, KAKENHI-PROJECT-13J06172
[Journal Article] カドミウムに曝露した血管内皮細胞におけるZIP8の発現2014
- Author(s)
  髙橋涼香，山本千夏，鍜冶利幸
- Journal Title
  
  薬学雑誌
  
  Volume: 134 Pages: 805-807
- NAID
  130004756448
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390034
[Journal Article] A convenient method to assess chemical modification of protein thiols by electrophilic metals2013
- Author(s)
  Toyama, T., Shinkai, Y., Kaji, T. and Kumagai, Y.
- Journal Title
  
  JOURNAL OF TOXICOLOGICAL SCIENCES
  
  Volume: 38 Pages: 477-484
- NAID
  10031158913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390034
[Journal Article] A convenient method to assess chemical modification of protein thiols by electrophilic metals2013
- Author(s)
  Toyama, T., Shinkai, Y., Kaji, T. and Kumagai, Y.
- Journal Title
  
  JOURNAL OF TOXICOLOGICAL SCIENCES
  
  Volume: 38 Pages: 477-484
- NAID
  10031158913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659058
[Journal Article] Effect of a Congolese herbal medicine used in sickle cell anemia on the expression of plasminogen activators in human coronary aortic endothelial cell culture2013
- Author(s)
  Nsimba, M.M., Yamamoto, C., Lami, J.N., Hayakawa, Y., and Kaji, T.
- Journal Title
  
  JOURNAL OF ETHNOPHARMACOLOGY
  
  Volume: 146 Issue: 2 Pages: 594-599
- DOI
  10.1016/j.jep.2013.01.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390034, KAKENHI-PROJECT-24659058
[Journal Article] Decreased thrombin activity by a Congolese herbal medicine used in sicklecellanemia2013
- Author(s)
  Nsimba, M.M., Lami, J.N., Hayakawa, Y., Yamamoto, C., and Kaji, T.
- Journal Title
  
  JOURNAL OF ETHNOPHARMACOLOGY
  
  Volume: 148 Issue: 3 Pages: 895-900
- DOI
  10.1016/j.jep.2013.05.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390034, KAKENHI-PROJECT-24659058
[Journal Article] Expression of VEGF-related proteins in cultured human brain microvascular endothelial cells and pericytes after exposure to methylmercury2013
- Author(s)
  Hirooka, T., Yamamoto, C., Yasutake, A., Eto, K., and Kaji, T.
- Journal Title
  
  JOURNAL OF TOXICOLOGICAL SCIENCES
  
  Volume: 38 Pages: 837-845
- NAID
  130004447087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659058
[Journal Article] Expression of VEGF-related proteins in cultured human brain microvascular endothelial cells and pericytes after exposure to methylmercury2013
- Author(s)
  Hirooka, T., Yamamoto, C., Yasutake, A., Eto, K., and Kaji, T.
- Journal Title
  
  JOURNAL OF TOXICOLOGICAL SCIENCES
  
  Volume: 38 Pages: 837-845
- NAID
  130004447087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390034
[Journal Article] Bismuth protects against arsenite-induced inhibition of proteoglycan synthesis in cultured vascular endothelial cells2012
- Author(s)
  Fujiwara, Y., Yamamoto, C., Inagaki, T., Satoh, M., and Kaji, T.
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 37 Pages: 837-843
- NAID
  10030502600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659058
[Journal Article] S-Mercuration of rat sorbitol dehydrogenase by methylmercury causes its aggregation and the release of the zinc ion from the active site2012
- Author(s)
  Hironori Kanda, Takashi Toyama, Azusa Shinohara-Kanda, Akihiro Iwamatsu, Yasuhiro Shinkai, Toshiyuki Kaji, Makoto Kikushima, Yoshito Kumagai
- Journal Title
  
  Achieves of Toxicology
  
  Volume: 86 Issue: 11 Pages: 1693-1702
- DOI
  10.1007/s00204-012-0893-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-24390034, KAKENHI-PROJECT-24659058, KAKENHI-PUBLICLY-23117703
[Journal Article] The cytotoxicity of methylmercury in human microvascular endothelial cells and pericytes in culture2012
- Author(s)
  Hirooka, T., and Kaji, T.
- Journal Title
  
  Biological & Pharmaceutical Bulletin
  
  Volume: 36 Pages: 1201-1205
- NAID
  130001872154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659058
[Journal Article] Cellular defense mechanisms against lead toxicity in the vascular system2012
- Author(s)
  Shinkai, Y and Kaji, T
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 35 Pages: 1885-1891
- NAID
  130001872282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390034
[Journal Article] The cytotoxicity of methylmercury in human microvascular endothelial cells and pericytes in culture2012
- Author(s)
  Hirooka, T. and Kaji, T.
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: 36 Pages: 1201-1205
- NAID
  130001872154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390034
[Journal Article] In vitro reversal of deformity and inhibition of aggregation of scikle red blood cells by two Congolese herbal medicines2012
- Author(s)
  Nsimba, M.M., Lami, J.M., Yamamoto, C., Kaji, T., Mukengeshaie, M., and Lufuluabo, M.
- Journal Title
  
  Journal of Medical Plants Research
  
  Volume: 6 Pages: 4801-4808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659058
[Journal Article] Cellular defense mechanisms against lead toxicity in the vascular system2012
- Author(s)
  Shinkai, Y. and Kaji, T.
- Journal Title
  
  Biological & Pharmaceutical Bulletin
  
  Volume: 35 Pages: 1885-1891
- NAID
  130001872282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659058
[Journal Article] Bis (L-cysteinato) zincate (II) as a coordination compound that induces metalloothionein gene transcription without inducing cell-stress-related gene transcription2012
- Author(s)
  Kimura, T., et al.
- Journal Title
  
  J.Inorg. Biochem.
  
  Volume: 117 Pages: 140-146
- DOI
  10.1016/j.jinorgbio.2012.07.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390034, KAKENHI-PROJECT-24659058
[Journal Article] Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway.2010
- Author(s)
  Shinkai, Y., Yamamoto, C., Kaji, T.
- Journal Title
  
  Toxicol. Sci. 114
  
  Pages: 378-386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Cell-density-dependent methylmercury susceptibility of cultured human brain microvascular pericytes.2010
- Author(s)
  Hirooka, T., Fujiwara, Y., Minami, Y., Ishii, A., Ishigooka, M., Shinkai, Y., Yamamoto, C., Satoh, M., Yasutake, A., Eto, K., Kaji, T.
- Journal Title
  
  Toxicol.In Vitro 24
  
  Pages: 835-841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Resistance of human brain microvascular endothelial cells in culture to methylmercury: Cell-density-dependent defense mechanisms.2010
- Author(s)
  Hirooka, T., Fujiwara, Y., Shinkai, Y., Yamamoto, C., Yasutake,, A., Satoh, M., Eto, K., Kaji, T.
- Journal Title
  
  J. Toxicol. Sci. (in press)
- NAID
  10026469510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Suppression of fibroblast growth facor-2 expression : Possible mechanism underlying the methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells2009
- Author(s)
  Hirooka, T., Fujiwara, Y., Inoue, S., Shinkai, Y., Yamamoto, C., Masahiko, S., Yasutake, A., Eto, K.and Kaji, T.
- Journal Title
  
  J. Toxicol. Sci. 34
  
  Pages: 433-439
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes2009
- Author(s)
  Shinkai, Y., Sumi, D., Toyama, T., Kaji, T.and Kumagai, Y.
- Journal Title
  
  Toxicol. Appl. Pharmacol. 237
  
  Pages: 232-236
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Suppression of fibroblast growth facor-2 expression: Possible mechanism underlying the methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells.2009
- Author(s)
  Hirooka, T., Fujiwara, Y., Inoue, S., Shinkai, Y., Yamamoto, C., Masahiko, S., Yasutake, A., Eto, K., Kaji, T.
- Journal Title
  
  J. Toxicol. Sci. 34
  
  Pages: 433-439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.2009
- Author(s)
  Shinkai, Y., Sumi, D., Toyama, T., Kaji, T., Kumagai, Y.
- Journal Title
  
  Toxicol. Appl. Pharmacol. 237
  
  Pages: 232-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Arsenite but not arsenate Inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells.2008
- Author(s)
  Fujiwara, Y., Yamamoto, C., Hirooka, T., Terada, N., Satoh, M., Kaji, T.
- Journal Title
  
  J. Toxicol. Sci. 33
  
  Pages: 487-492
- NAID
  110006950529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Arsenite but not arsenate Inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells2008
- Author(s)
  Fujiwara, Y., Yamamoto, C., Hirooka,T., Terada, N., Satoh, M.and Kaji, T.
- Journal Title
  
  J. Toxicol. Sci. 33
  
  Pages: 487-492
- NAID
  110006950529
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Methylmercury retards the repair of wounded monolayer of human brain microvascular endothelial cells by inhibiting their proliferation without nonspecific cell damage.2007
- Author(s)
  Hirooka, T., Fujiwara, Y., Yamamoto, C., Yasutake, A., Kaji, T.
- Journal Title
  
  J. Health Sci. 53
  
  Pages: 450-456
- NAID
  110006366926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Methylmercury retards the repair of wounded monolayer of human brain microvascular endothelial cells by inhibiting their proliferation without nonspecific cell damage2007
- Author(s)
  Hirooka, T., Fujiwara, Y., Yamamoto, C., Yasutake, A.and Kaji, T.
- Journal Title
  
  J. Health Sci. 53
  
  Pages: 450-456
- NAID
  110006366926
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] The vascular endothelial growth factor VEGF165 induces perlecan synthesis via VEGF receptor-2 in cultured human brain microvascular endothelial cells2006
- Author(s)
  Kaji, T., Yamamoto, C., Oh-i, M., Fujiwara, Y., Yamazaki, Y., Morita, T., Plaas, A. H.and Wight, T.N.
- Journal Title
  
  Biochim. Biophys. Acta 1760
  
  Pages: 1465-1474
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] The vascular endothelial growth factor VEGF165 induces perlecan synthesis via VEGF receptor-2 in cultured human brain microvascular endothelial cells2006
- Author(s)
  Kaji, T. et al.
- Journal Title
  
  Biochemica et Biophysica A eta 1760
  
  Pages: 1465-1474
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] The vascular endothelial growth factor VEGF165 induces perlecan synthesis via VEGF receptor-2 in cultured human brain microvascular endothelial cells.2006
- Author(s)
  Kaji, T., Yamamoto, C., Oh-i, M., Fujiwara, Y., Yamazaki, Y., Morita, T., Plaas, A.H., Wight, T.N.
- Journal Title
  
  Biochim. Biophys. Acta 1760
  
  Pages: 1465-1474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390042
[Journal Article] Identification and functions of chondroitin sulfate in the milieu of neural stem cells.2006
- Author(s)
  Ida, M., Shuo, T., Hirano, K., Tokita, Y., Nakanishi, K., Matsui, F., Aono, S., Fujita, H., Fujiwara, Y., Kaji, T., Oohira, A.
- Journal Title
  
  J.Biol.Chem. 281
  
  Pages: 5982-5991
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Proteoglycans predominantly synthesized by human brain microvascular endothelial cells in culture are perlecan and biglycan.2005
- Author(s)
  Yamamoto, C., Deng, X., Fujiwara, Y., Kaji, T.
- Journal Title
  
  J.Health Sci. 51
  
  Pages: 576-583
- NAID
  110003666529
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Induction of synthesis of a large heparan sulfate proteoglycan, perlecan, by thrombin in cultured human coronary smooth muscle cells.2005
- Author(s)
  Yamamoto, C., Wakata, T., Fujiwara, Y., Kaji, T.
- Journal Title
  
  Biochim.Biophys.Acta 1722
  
  Pages: 92-102
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Characterization of chondroitin/dermatan sulfate proteoglycans synthesized by bovine retinal pericytes in culture2004
- Author(s)
  Kaji T et al.
- Journal Title
  
  Biological & Pharmaceutical Bulletin 27
  
  Pages: 1763-1768
- NAID
  110003608693
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Differential regulation of biglycan and decorin synthsis by connective tissue growth factor in cultured vascular endothelial cells2004
- Author(s)
  Kaji T et al.
- Journal Title
  
  Biochemical and Biophysical Research Communications 322
  
  Pages: 22-28
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Characterization of chondroitin/dermatan sulfate proteoglycans synthesized by bovine retinal pericytes in culture2004
- Author(s)
  Kaji T et al.
- Journal Title
  
  Biol. Pharm. Bull 27
  
  Pages: 1763-1768
- NAID
  110003608693
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Stimulation of proteoglycan release from cultured vascular endothelial cell layers by sodium spirulan2004
- Author(s)
  Kaji T et al.
- Journal Title
  
  Journal of Health Science 50
  
  Pages: 654-659
- NAID
  110003666017
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Differential regulation of biglycan and decorin synthesis by connective tissue growth factor in cultured vascular endothelial cells2004
- Author(s)
  Kaji T et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 322
  
  Pages: 22-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Characterization of chondroitin/dermatan sulfate proteoglycans synthesized by bovine retinal pericytes in culture.2004
- Author(s)
  Kaji, T., Sakurai, S., Yamamoto, C., Fujiwara, Y., Yamagishi, S., Yamamoto, H., Kinsella, M.G., Wight, T.N.
- Journal Title
  
  Biol.Pharm.Bull. (Highlighted paper selected by Editor in-chief) 27
  
  Pages: 1763-1768
- NAID
  110003608693
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590070
[Journal Article] Differential regulation of biglycan and decorin synthesis by connective tissue growth factor in cultured vascular endothelial cells.2004
- Author(s)
  Kaji, T., Yamamoto, C., Oh-i, M., Nishida, T., Takigawa, M.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 322
  
  Pages: 22-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590070
[Presentation] TGF-β1-ALK5-Smad2/3/4-ATF4経路を介した活性イオウ分子の増加はTGF-β1の血管内皮細胞増殖抑制作用をmodulateする2021
- Author(s)
  高橋結，藤江智也，中野毅，新開泰弘，熊谷嘉人，山本千夏，鍜冶利幸
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19K07089
[Presentation] 鉛による血管内皮細胞の活性イオウ分子合成の誘導とその機構2021
- Author(s)
  高橋結、藤江智也、宇田川直利、新開泰弘、熊谷嘉人、山本千夏、鍜冶利幸
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07089
[Presentation] FGF-2の血管内皮細胞増殖の促進への活性イオウ分子の関与2021
- Author(s)
  高橋結，藤江智也，久保田采佳，岩井瑠里，山本千夏，鍜冶利幸
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K07089
[Presentation] 鉛はPERK-ATF4経路の活性化によって血管内皮細胞の活性イオウ分子産生を促進させる2021
- Author(s)
  高橋結，藤江智也，宇多川直利，中野剛，新開泰弘，熊谷嘉人，山本千夏，鍜冶利幸
- Organizer
  メタルバイオサイエンス研究会2021
- Data Source
  KAKENHI-PROJECT-19K07089
[Presentation] 重金属のシグナルトキシコロジー2020
- Author(s)
  鍜冶利幸
- Organizer
  第47回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07089
[Presentation] TGF-β1による血管内皮細胞の活性イオウ分子産生酵素発現調節2020
- Author(s)
  髙橋結，藤江智也，髙橋茜，山本千夏，鍜冶利幸
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19K07089
[Presentation] TGF-β1による培養血管内皮細胞の活性イオウ分子産生酵素の発現調節を担う細胞内シグナル経路2020
- Author(s)
  高橋結，藤江智也，高橋茜，山本千夏，鍜冶利幸
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K07089
[Presentation] FGF-2 による血管内皮細胞の活性イオウ分子産生酵素 CSE の発現誘導2020
- Author(s)
  久保田采佳，髙橋結，藤江智也，山本千夏，鍜冶利幸
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19K07089
[Presentation] TGF-β1による培養血管内皮細胞の活性イオウ分子産生酵素群の発現調節2020
- Author(s)
  高橋結，高橋茜，藤江智也，山本千夏，鍜冶利幸
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07089
[Presentation] メチル水銀毒性発現機序の解明に向けた挑戦2020
- Author(s)
  鍜冶利幸
- Organizer
  第47回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07089
[Presentation] TGF-β1による培養血管内皮細胞の活性イオウ分子産生酵素の発現調節を担う細胞内シグナル経路2020
- Author(s)
  髙橋結，藤江智也，髙橋茜，山本千夏，鍜冶利幸
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K07089
[Presentation] 血管内皮細胞において銅錯体 Cu10 は ERK/p38 MAPK 経路を介して活性イオウ分子産生酵素 CSE の転写を誘導する2019
- Author(s)
  高橋茜，高橋結，藤江智也，原崇人，山本千夏，中寛史，鍜冶利幸
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-19K07089
[Presentation] 金属のシグナルトキシコロジー2019
- Author(s)
  鍜冶利幸
- Organizer
  メタルバイオサイエンス研究会2019
- Invited
- Data Source
  KAKENHI-PROJECT-19K07089
[Presentation] 血管内皮細胞のメタロチオネイン誘導における活性イオウ産生酵素の役割2019
- Author(s)
  遠藤広貴, 藤江智也, 山本千夏, 鍜冶利幸
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K07089
[Presentation] 亜鉛錯体による血管内皮細胞特異的なグリコサミノグリカン合成の調節2018
- Author(s)
  原崇人，酒巻沙弥香，中村武浩，鍜冶利幸，山本千夏
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08047
[Presentation] 有機－無機ハイブリッド分子を活用した血管内皮細胞のメタロチオネイン転写誘導機構の解析2018
- Author(s)
  竹中福太，吉田映子，藤江智也，山本千夏，安池修之，鍜冶利幸
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] バイオオルガノメタリクスの到達点と課題2017
- Author(s)
  鍜冶利幸
- Organizer
  東京理科大学総合研究院バイオオルガノメタリクス研究部門研究交流会
- Place of Presentation
  東京理科大学神楽坂校舎2号館（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] 亜鉛錯体を用いた内皮細胞シンデカン-4の新規発現調節機構の解析2017
- Author(s)
  原崇人，中村武浩，松崎紘佳，吉田映子，山本千夏，鍜冶利幸
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15K08047
[Presentation] 有機-無機ハイブリッド分子の血管毒性学2017
- Author(s)
  鍜冶利幸
- Organizer
  プラズマ分光分析研究会第99回講演会
- Invited
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] ジチオカルバメート錯体による血管内皮細胞選択的なメタロチオネイン発現の誘導2017
- Author(s)
  藤江智也，土田あずさ，中寛史，鍜冶利幸，山本千夏
- Organizer
  フォーラム2017 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] 鉛による血管内皮細胞増殖の阻害に関与するヘパラン硫酸プロテオグリカンの大型分子種パールカンの発現抑制機構2017
- Author(s)
  熊谷玲衣奈，原崇人，吉田映子，藤原泰之，山本千夏，鍜冶利幸
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15K08047
[Presentation] ジチオカルバメート錯体による血管内皮および平滑筋細胞のメタロチオネイン発現の誘導2017
- Author(s)
  藤江智也，土田あずさ，中寛史，鍜冶利幸，山本千夏
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] 銅錯体による血管平滑筋細胞のメタロチオネイン発現の誘導2017
- Author(s)
  藤江智也，二宮早紀，中寛史，鍜冶利幸，山本千夏
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] TGF- βシグナルを介した血管内皮細胞メタロチオネインの誘導2017
- Author(s)
  土田翼，藤江智也，吉田映子，藤原泰之，山本千夏，鍜冶利幸
- Organizer
  フォーラム2017 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] ジチオカルバメート銅錯体Cu10による血管内皮細胞のシンデカン-4発現誘導2017
- Author(s)
  立石紘子，原崇人，藤江智也，吉田映子，山本千夏，中寛史，鍜冶利幸
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15K08047
[Presentation] バイオオルガノメタリクス：重金属毒性学から生まれた新しい研究戦略2017
- Author(s)
  鍜冶利幸
- Organizer
  国際科学技術共同研究推進事業戦略的国際共同研究プログラム：日本ー中国共同研究都市における環境問題または都市におけるエネルギー問題に関する研究分野
- Invited
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] 銅錯体を用いた血管内皮細胞のプロテオグリカン発現調節機構の解析2017
- Author(s)
  立石紘子，原崇人，吉田映子，藤江智也，山本千夏，中寛史，鍜冶利幸
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15K08047
[Presentation] 重金属の細胞毒性に対する血管内皮細胞の防御系2017
- Author(s)
  藤江智也，山本千夏，鍜冶利幸
- Organizer
  第44回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] ジチオカルバメート銅錯体による血管内皮細胞のプロテオグリカン発現調節2016
- Author(s)
  立石紘子，原崇人，藤江智也，吉田映子，山本千夏，中寛史，鍜冶利幸
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学旗の台キャンパス（東京都・品川区）
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-15K08047
[Presentation] 有機ロジウム化合物を活用した血管内皮細胞のパールカン発現抑制機構の解明への試み2016
- Author(s)
  松崎紘佳，原崇人，吉田映子，藤原泰之，山本千夏，斎藤慎一，鍜冶利幸
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学旗の台キャンパス（東京都・品川区）
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-15K08047
[Presentation] 銅錯体による血管内皮細胞メタロチオネイン誘導を介在する亜鉛輸送体ZIP7の発現誘導2016
- Author(s)
  藤江智也，森田遥香，吉田映子，藤原泰之，山本千夏，中寛史，鍜冶利幸
- Organizer
  日本毒性学会第43回学術年会
- Place of Presentation
  愛知県産業労働センター（愛知県名古屋市）
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] 亜鉛輸送体ZIP7を介した銅錯体による血管内皮細胞メタロチオネイン誘導2015
- Author(s)
  森田遥香，藤江智也，吉田映子，鍜冶利幸
- Organizer
  第２回東京環境健康薬学研究会
- Place of Presentation
  東京理科大学（東京都新宿区神楽坂）
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 有機金属化合物の細胞毒性2015
- Author(s)
  山本千夏，安池修之，鍜冶利幸
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  金沢市アートホール（石川県金沢市）
- Year and Date
  2015-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 有機-無機ハイブリッド分子を活用した血管内皮細胞メタロチオネイン誘導機構の解析2015
- Author(s)
  藤江智也，鍜冶利幸
- Organizer
  第２回東京環境健康薬学研究会
- Place of Presentation
  東京理科大学（東京都新宿区神楽坂）
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] 重金属の血管毒性研究からバイオ元素戦略バイオオルガノメタリクスへ2015
- Author(s)
  鍜冶利幸
- Organizer
  第604回新潟薬科大学薬学総合セミナー
- Place of Presentation
  新潟薬科大学（新潟県新潟市）
- Year and Date
  2015-11-27
- Invited
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] 銅錯体による血管内皮細胞メタロチオネイン誘導を制御する亜鉛輸送体 ZIP72015
- Author(s)
  森田遥香，藤江智也，中寛史，吉田映子，鍜冶利幸
- Organizer
  フォーラム2015：衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸学院大学（兵庫県神戸市）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 血管平滑筋細胞におけるTGF-β1による亜鉛輸送体ZIP8遺伝子の発現調節機構2015
- Author(s)
  武正文子，吉田映子，山本千夏，藤原泰之，鍜冶利幸
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  金沢市アートホール（石川県金沢市）
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 有機-無機ハイブリッド分子を活用した血管内皮細胞のメタロチオネイン誘導機構の解明2015
- Author(s)
  鍜冶利幸
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  ホテル日航金沢（石川県金沢市）
- Year and Date
  2015-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 有機金属化合物の細胞毒性2015
- Author(s)
  山本千夏，安池修之，鍜冶利幸
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  ホテル日航金沢（石川県金沢市）
- Year and Date
  2015-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] 銅錯体による血管内皮細胞メタロチオネイン誘導を制御する亜鉛輸送体 ZIP72015
- Author(s)
  森田遥香，藤江智也，中寛史，吉田映子，鍜冶利幸
- Organizer
  フォーラム2015 衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸学院大学（兵庫県神戸市）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] 有機-無機ハイブリッド分子を活用した血管内皮細胞のメタロチオネイン誘導機構の解明2015
- Author(s)
  鍜冶利幸
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  金沢市アートホール（石川県金沢市）
- Year and Date
  2015-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-15K14992
[Presentation] 重金属の血管毒性研究からバイオ元素戦略バイオオルガノメタリクスへ2015
- Author(s)
  鍜冶利幸
- Organizer
  第604回新潟薬科大学薬学総合セミナー
- Place of Presentation
  新潟薬科大学（新潟県新潟市）
- Year and Date
  2015-11-27
- Invited
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 脂肪細胞分化及び脂肪滴の蓄積を抑制する亜鉛錯体の同定2014
- Author(s)
  峯松真梨，小野寺章，石橋孝文，岡若奈，武田直也，弘内淳美，矢埜みなみ，山本麻記子，米倉玲奈，安池修之，中寛史，内山真伸 , 佐藤雅彦，鍜冶利幸，伊藤徳夫，河合裕一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] 有機アンチモン化合物による血管内皮細胞のメタロチオネイン誘導2014
- Author(s)
  村上正樹，藤江智也，松村実生，藤原泰之，木村朋紀，安池修之，山本千夏，佐藤雅彦，鍜冶利幸
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] 有機ビスマス化合物によるヒト Glyoxalase I 阻害の構造活性相関の検討2014
- Author(s)
  高澤涼子，嶋田奈実，安池修之，鍜冶利幸，田沼靖一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] 有機ビスマス化合物によるヒトGlyoxalase I 阻害の構造活性相関の検討2014
- Author(s)
  高澤涼子，嶋田奈実，安池修之，鍜冶利幸，田沼靖一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] バイオオルガノメタリクスへの招待2014
- Author(s)
  鍜冶利幸
- Organizer
  東京理科大学総合研究機構分子連関相乗系研究部門平成25年度成果報告会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] 骨粗鬆症モデルマウスへの Zn(bpy)Cl2 の有効性評価2014
- Author(s)
  石橋孝文，小野寺章，岡若奈，武田直也，弘内淳美，峯松真梨，矢埜みなみ，山本麻記子，米倉玲奈，安池修之，中寛史，内山真伸，佐藤雅彦，鍜冶利幸，伊藤徳夫，河合裕一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] 脂肪細胞分化及び脂肪滴の蓄積を抑制する亜鉛錯体の同定2014
- Author(s)
  峯松真梨，小野寺章，石橋孝文，岡若奈，武田直也，弘内淳美，矢埜みなみ, 山本麻記子，米倉玲奈，安池修之，中寛史，内山真伸 , 佐藤雅彦，鍜冶利幸，伊藤徳夫，河合裕一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 血管内皮細胞に対する亜鉛とカドミウム相互作用は金属輸送体ZIP8の発現に介在される2014
- Author(s)
  上原茜，山本千夏，鍜冶利幸
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] バイオオルガノメタリクスへの招待2014
- Author(s)
  鍜冶利幸
- Organizer
  東京理科大学総合研究機構分子連関相乗系研究部門平成25年度成果報告会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 骨粗鬆症モデルマウスへの Zn(bpy)Cl2 の有効性評価2014
- Author(s)
  石橋孝文，小野寺章，岡若奈，武田直也，弘内淳美，峯松真梨，矢埜みなみ，山本麻記子，米倉玲奈，安池修之，中寛史，内山真伸，佐藤雅彦，鍜冶利幸，伊藤徳夫，河合裕一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 血管内皮細胞においてビグリカンはTGF-βと協調してSmad経路に介在されるシンデカン-4の発現を抑制する2014
- Author(s)
  原崇人，新開泰弘，山本千夏，熊谷嘉人，鍜冶利幸
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 有機アンチモン化合物による血管内皮細胞のメタロチオネイン誘導2014
- Author(s)
  村上正樹，藤江智也，松村実生，藤原泰之，木村朋紀，安池修之，山本千夏，佐藤雅彦，鍜冶利幸
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 血管内皮細胞においてNrf2およびメタロチオネインを誘導する有機-無機ハイブリッド分子2013
- Author(s)
  藤江智也，中寛史，立浪忠志，新開泰弘，山本千夏，藤原泰之，佐藤雅彦，熊谷嘉人，鍜冶利幸
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] バイオオルガノメタリクス（有機-無機ハイブリッド分子のバイオロジー）とは？2013
- Author(s)
  鍜冶利幸
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  千葉
- Invited
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 血管内皮細胞におけるFGF-2による亜鉛トランスポーター発現の調節2013
- Author(s)
  蜂須賀絵美,山本千夏,鍜冶利幸
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-30
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 有機-無機ハイブリッド分子による生体防御系の活性化2013
- Author(s)
  藤江智也, 中寛史, 立浪忠志, 山本千夏, 廣岡孝志, 安池修之, 新開泰弘, 熊谷嘉人, 内山真伸, 鍜冶利幸
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] 血管内皮細胞においてNrf2およびメタロチオネインを誘導する有機-無機ハイブリッド分子2013
- Author(s)
  藤江智也，中寛史，立浪忠志，新開泰弘，山本千夏，藤原泰之，佐藤雅彦，熊谷嘉人，鍜冶利幸
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] カドミウムに曝露した血管内皮細胞におけるZIP8の発現誘導2013
- Author(s)
  高橋涼香,藤江智也,山本千夏,鍜冶利幸
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] プロテオグリカンを発現誘導する有機アンチモン化合物の設計・合成・機能解析と構造活性相関研究2013
- Author(s)
  中裕之, 滝田良, 鍜冶利幸, 内山真伸
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] ビスマスまたはアンチモンを導入した有機金属化合物の毒性発現とそのメカニズム2013
- Author(s)
  郡久美子, 中浴静香, 山本千夏, 安池修之,　角澤直紀,　栗田城治,　鍜治利幸
- Organizer
  第12回分子予防環境医学研究会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] カドミウムの血管内皮細胞毒性2013
- Author(s)
  山本千夏,鍜冶利幸
- Organizer
  日本衛生学会第83回学術総会
- Place of Presentation
  金沢(招待講演)
- Year and Date
  2013-03-24
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] バイオオルガノメタリクス（有機-無機ハイブリッド分子のバイオロジー）とは？2013
- Author(s)
  鍜冶利幸
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  千葉
- Invited
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] Cytotoxicity of organobismuth and organoantimony compounds2012
- Author(s)
  Kohri K., Yamamoto C., Yasuike S., Kakusawa N., Kurita J., Kaji T.
- Organizer
  The 6th International Congress of Asian Society of Toxicology
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] FGF-2による血管内皮細胞の亜鉛トランスポーター発現の調節2012
- Author(s)
  蜂須賀絵美,山本千夏,鍛冶利幸
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Year and Date
  2012-07-18
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 有機ビスマス化合物とそのアンチモン置換体の細胞毒性の特徴2012
- Author(s)
  郡久美子，山本千夏，安池修之，角澤直紀，栗田城治，鍜冶利幸
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] Cytotoxicity of organobismuth and organoantimony compounds in vitro2012
- Author(s)
  郡久美子，山本千夏，安池修之，角澤直紀，栗田城治，鍜冶利幸
- Organizer
  第22回金属の関与する生体関連反応シンポジウム（SRM2012）
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] カドミウムによる血管内皮細胞ZIP 8の誘導2012
- Author(s)
  高橋涼香,藤江智也,山本千夏,鍛冶利幸
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Year and Date
  2012-07-18
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] バイオオルガノメタリクス：有機－無機ハイブリッド分子のバイオロジー2012
- Author(s)
  鍜冶利幸
- Organizer
  東京理科大学総合研究機構バイオオルガノメタリクス研究部門研究交流集会
- Place of Presentation
  野田
- Invited
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] 有機ビスマス化合物の細胞毒性はそのアンチモン置換体では消失する2012
- Author(s)
  郡久美子，中浴静香，山本千夏，安池修之，角澤直紀，栗田城治，鍛冶利幸
- Organizer
  フォーラム2012衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] 血管内皮細胞に対するカドミウムの毒性発現機構2012
- Author(s)
  山本千夏,鍜冶利幸
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台(招待講演)
- Year and Date
  2012-07-18
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] Induction of metal transporter SLC39A8 by cadmium in vascular endothelial cells2012
- Author(s)
  高橋涼香,藤江智也,山本千夏,鍛冶利幸
- Organizer
  第22回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] Cadmium selectively and strongly induces the expression of ZIP 8 1n vascular end othelial cells2012
- Author(s)
  Takahashi S., Fujie T., Yamamoto C., Kaji T.
- Organizer
  The 6th International Congress of Asian Society of Toxicology
- Place of Presentation
  仙台
- Year and Date
  2012-07-20
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] Induction of SLC39A8 expression by FGF-2 in vascular endothelial cells2012
- Author(s)
  Hachisuka E., Yamamoto C., Kaji T.
- Organizer
  The 6th International Congress of Asian Society of Toxicology
- Place of Presentation
  仙台
- Year and Date
  2012-07-20
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] メチル水銀は脳浮腫形成に関与する脳血管組織のVEGFシステムを活性化する.2010
- Author(s)
  廣岡孝志, 新開泰弘, 山本千夏, 安武章, 衞藤光明, 鍜冶利幸
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀のヒト脳微小血管内皮細胞への傷害性発現は低酸素環境下において増強される.2010
- Author(s)
  姫〓〓, 廣岡孝志, 山本千夏, 安武章, 衞藤光明, 鍜冶利幸
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] 伝統的金属毒性学から新しい金属生物学への展開2010
- Author(s)
  鍛冶利幸
- Organizer
  筑波大学大学院特別セミナー
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀は培養ヒト脳微小血管内皮細胞および周皮細胞のヒアルロナン合成を促進する.2009
- Author(s)
  廣岡孝志, 山本千夏, 安武章, 衞藤光明, 鍜冶利幸
- Organizer
  フォーラム2009:衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀中毒ラットの小脳顆粒細胞層における炎症性変化を伴った退行性変化.2009
- Author(s)
  杜可, 廣岡孝志, 山本千夏, 安武章, 勝田省吾, 鍜冶利幸
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀による小脳障害のメカニズムに関する新しい仮説.2009
- Author(s)
  廣岡孝志, 杜可, 山本千夏, 安武章, 衞藤光明, 勝田省吾, 鍜冶利幸
- Organizer
  第36回日本トキシコロジー学会学術年会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀の部位特異的な中枢神経障害発現要因としての血管毒性.シンポジウム:若手が切り開くMolecular Toxicology 4～有害金属類の毒性発現と防御を担う分子標的と生体応答システム～.2009
- Author(s)
  廣岡孝志, 鍜冶利幸
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀中毒ラットの小脳顆粒細胞層における炎症性変化を伴った退行性変化2009
- Author(s)
  杜可, 廣岡孝志, 山本千夏, 安武章, 勝田省吾, 鍜冶利幸
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀はヒト脳微小血管周皮細胞においてシンデカン-4の発現を誘導する2008
- Author(s)
  田中満崇, 廣岡孝志, 藤原泰之, 井上頌子, 山本千夏, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] VEGFの自己分泌/傍分泌型調節システムは脳微小血管組織におけるメチル水銀毒性の標的である.2008
- Author(s)
  廣岡孝志, 山本千夏, 石井明彦, 石郷岡美緒, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  フォーラム2008衛生薬学・環境トキシコロジー
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀投与ラット脳の病理組織学的変化:小脳障害のメカニズムに関する新しい仮説.2008
- Author(s)
  杜可, 山本千夏, 廣岡孝志, 安武章, 勝田省吾, 鍜冶利幸
- Organizer
  フォーラム2008衛生薬学・環境トキシコロジー
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀はヒト脳微小血管周皮細胞においてシンデカン-4の発現を誘導する.2008
- Author(s)
  田中満崇, 廣岡孝志, 藤原泰之, 井上頌子, 山本千夏, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] ヒト脳微小血管周皮細胞に対するメチル水銀の細胞密度依存的な傷害性.2008
- Author(s)
  廣岡孝志, 藤原泰之, 南有香, 山本千夏, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] VEGFの自己分泌/傍分泌型調節システムは脳微小血管組織におけるメチル水銀毒性の標的である2008
- Author(s)
  廣岡孝志, 山本千夏, 石井明彦, 石郷岡美緒, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  フォーラム2008衛生薬学・環境トキシコロジー
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀は傷害した培養脳微小血管内皮細胞層の修復をFGF-2システムの抑制を通じて阻害する2007
- Author(s)
  廣岡孝志, 藤原泰之, 山本千夏, 井上頌子, 南有香, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  メタロチオネインおよびメタロバイオサイエンス研究会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] 重金属と血管病変2007
- Author(s)
  鍛冶利幸
- Organizer
  第34回日本トキシコロジー学会学術年会シンポジウム「環境汚染物質と生活習慣病」
- Place of Presentation
  東京
- Year and Date
  2007-06-27
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀による傷害内皮細胞層の修復阻害:FGF-2系およびVEGF系は関与するか?2007
- Author(s)
  廣岡孝志, 藤原泰之, 山本千夏, 井上頌子, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  フォーラム2007衛生薬学・環境トキシコロジー
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] メチル水銀は傷害した培養脳微小血管内皮細胞層の修復をFGF-2システムの抑制を通じて阻害する.2007
- Author(s)
  廣岡孝志, 藤原泰之, 山本千夏, 井上頌子, 南有香, 新開泰弘, 安武章, 鍜冶利幸
- Organizer
  メタロチオネインおよびメタロバイオサイエンス研究会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] ヒト脳微小血管内皮細胞の維持に対するメチル水銀の毒性2007
- Author(s)
  廣岡孝志, 藤原泰之, 山本千夏, 安武章, 鍜冶利幸.
- Organizer
  第8回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-18390042
[Presentation] 血管内皮細胞において亜鉛は金属輸送体ZIP8の発現抑制を介してカドミウムの細胞毒性を防御する
- Author(s)
  上原茜，山本千夏，鍜冶利幸
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸コンベンションセンター（兵庫県）
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 血管内皮細胞に対する有機テルル化合物の毒性の置換基による修飾
- Author(s)
  岡﨑貴大，中浴静香，吉田映子，藤原泰之，山本千夏，安池修之，鍜冶利幸
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂（石川県）
- Year and Date
  2015-06-29 – 2015-07-01
- Data Source
  KAKENHI-PROJECT-24659058
[Presentation] カドミウムの内皮細胞毒性に対する亜鉛の防御機構への金属輸送体発現の関与
- Author(s)
  上原茜，吉田映子，山本千夏，鍜冶利幸
- Organizer
  フォーラム2014 衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば国際会議場（茨城県）
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-24390034
[Presentation] 有機ビスマス化合物の毒性発現に関与する遺伝子の探索
- Author(s)
  中浴静香，郡久美子，山本千夏，安池修之，鍜冶利幸
- Organizer
  フォーラム2014：衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば国際会議場（茨城県）
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-24659058

1. YAMAMOTO Chika (70230571)

# of Collaborated Projects: 7 results

# of Collaborated Products: 63 results
2. FUJIWARA Yasuyuki (40247482)

# of Collaborated Projects: 6 results

# of Collaborated Products: 21 results
3. MIYAZAKI Motoich (50009164)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MIYAJIMA Sawako (30278139)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. HIRAI Eiji (80019695)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. CHOHJI Tetsuji (80092790)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MURAMOTO ken-ichiro (70042835)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. UEKI Katsuji (10111337)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. YAMAGUCHI Kosuke

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. KITAMURA Moritsugu

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 全浩

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 李敏煕

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. ISOMURA Kazuaki (80037887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 周尾卓也 (90399006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 廣岡孝志 (50397519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 25 results
16. 小村純子 (20153679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. HARA Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 金煕江

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 韓義正

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HAO QUAN

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. EUI-JUNG HAN

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HUI-KANG KIM

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. MIN-HEE LEE

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 程子峰

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 金熈江

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 季敏熈

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 李敏熙

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. QUAN Hao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. LEE Min-Hee

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 庄田丈夫

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 山口幸裕

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. TAGUCHI Keiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 熊谷嘉人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kaji Toshiyuki 鍜冶 利幸

KAJI Toshiyuki 鍜冶 利幸

鍛治 利幸 カジ トシユキ

鍜治 利幸 カジ

Research Projects

Research Products

Co-Researchers

Expression, functions, and synthesis regulation of reactive sulfur species in vascular endothelial cellsPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Analysis of molecular mechanisms for vascular endothelial perlecan synthesis by the strategy of bio-organometallices

Principal Investigator

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Research Institution

Mechanisms underlying endothelial metallothionein induction based on the strategy of bioorganometallicsPrincipal Investigator

Principal Investigator

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Research Institution

Regulation of vascular endothelial cell functions and exhibition of heavy metal toxicity through zinc transporter expressionPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Molecular targets and biological systems involved in the toxicity of nucleophilic organometallic compoundsPrincipal Investigator

Principal Investigator

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Abnormal proteoglycan metabolism as a target of neurotoxicity of mechylmercuryPrincipal Investigator

Principal Investigator

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Research Institution

Regulation of glycosmainoglycan chain formation in proteoglycan molecules synthesized by brain vascular cellsPrincipal Investigator

Principal Investigator

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Research Institution

Characterization of proteoglycans expressed in brain vascular cells and regulation of their synthesisPrincipal Investigator

Principal Investigator

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細胞増殖因子による血管内皮細胞プロテオグリカン分子種の合成調節Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Clarification of characteristics, functions and regulation of proteoglycans synthesized by pericytesPrincipal Investigator

Principal Investigator

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Research Institution

増殖制御因子による血管内皮細胞プロテオグリカン分子種の産生調節Principal Investigator

Principal Investigator

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血管内皮細胞プロテオグリカンの産生と放出の調節を介在する細胞内情報伝達経路Principal Investigator

Principal Investigator

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Environmental Impact Assessment and Counter-plans for Acid Rain and Snow in the Circum-pan-Japan Sea Area (Japan, Korea and China)

Kaji Toshiyuki 鍜冶利幸

KAJI Toshiyuki 鍜冶利幸

鍛治利幸カジトシユキ

鍜治利幸カジ