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Sasaki Takashi  佐々木 敬

… Alternative Names

佐々木 敬  ササキ タカシ

SASAKI Takashi  佐々木 敬

Less
Researcher Number 90205849
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1413-6983
External Links
Affiliation (Current) 2025: 公益財団法人佐々木研究所, 附属研究所, 理事長
Affiliation (based on the past Project Information) *help 2014 – 2018: 東京慈恵会医科大学, 医学部, 教授
2007: Jikei University School of Medicine, Department of medicine, Professor
2002 – 2006: Jikei University School of Medicine, Department of Internal Medicine, Assistant Professor, 医学部, 助教授
1999 – 2001: 東京慈恵会医科大学, 医学部, 講師
1996 – 1997: 東京慈恵会医科大学, 医学部, 助手
1994: 東京慈恵会医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Metabolomics / Metabolomics / 内分泌・代謝学
Except Principal Investigator
Metabolomics / Biomedical engineering/Biological material science / 内分泌・代謝学
Keywords
Principal Investigator
インスリン / 再生医学 / 遺伝子 / 糖尿病 / インスリノーマ / adenoassociated virus / endocrine pancreas / cyclin-deuendent kinase / cvclin / insulin … More / aene therapy / cell cycle / reaenerative medicine / トランスレーショナルリサーチ / ウイルス / 膵臓 / ベータ細胞 / 増殖 / アデノ随伴ウイルス / 膵内分泌 / サイクリン依存性キナーゼ / サイクリン / 遺伝子治療 / 細胞周期 / 再生医療 / Mesenchyme / Precursor / Stem cell / Differentiation / Pancreas / Tissue Engineering / Insulin / Celltherapy / 前脂肪細胞 / レトロウイルスベクター / 細胞内輸送 / GFP / レトロウィルスベクター / レトロウイルス / 1型糖尿病 / 膵島移植 / フューリン / プロセッシング / プロホルモン / 間葉系 / 前駆細胞 / 幹細胞 / 分化 / 膵 / 再生 / 細胞治療 / HLA / Haplotype / TDT / Linkage Diseguilibrium / Transmission / Family Analysis / Genetic Instability / Genomic Imprinting / 抗GAD抗体 / ゲノムの不安定性 / IDDM / 膵島 / RT-PCR / データベース / RNA / 遺伝 / ゲノム / EST / PCR / 家系分析 / ハプロタイプ / インプリンティング / pancreatic islet / 培養 / シュワン細胞 / 神経堤 / 酸化ストレス / ゲノム編集 / gap junction / ブドウ糖応答性インスリン分泌 / Schwann細胞 / 膵島三次元構造 / 恒常性の破綻 / 自己組織化 / ブドウ糖応答性 / インスリン分泌 / 三次元培養法 / 膵島障害 … More
Except Principal Investigator
Insulin / furin / インスリン / AAV / Cytokeratin 19 / Bone marrow cells / Pancreatic duct cells / ngn-3遺伝子 / 細胞治療 / PDX-1遺伝子 / レーザーマイクロダイセクション / レーザーマククロダイセクション / 再生医学 / ネスチン / アデノ随伴ベクター / サイトケラチン / 骨髄細胞 / 膵管上皮細胞 / preadipocytes / Myoblasts / Cell device / hsp 70 promoter / Electrical stimulation / Gee expression / エンカプシレーション / 3T3L1細胞 / HSPプロモーター / レトロウイルス / 筋芽細胞 / 細胞デバイス / BIACORE法 / 電気刺激応答性 / hspプロモーター / 筋芽細胸 / 前脂肪細胞 / 遺伝子発現制御 / 抗GAD抗体 / genomic imprinting / HLA遺伝子 / IDDM Less
  • Research Projects

    (7 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (9 People)
  •  Function-structure relationship; role of the islet Schwann cellsPrincipal Investigator

    • Principal Investigator
      Sasaki Takashi
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Jikei University School of Medicine
  •  Inhibition of injury and promotion of regeneration in pancreatic islets of diabetes mellitus the by molecular interventionPrincipal Investigator

    • Principal Investigator
      SASAKI Takashi
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Jikei University School of Medicine
  •  Cell therapy for diabetes applied by pancreatic duct cells.

    • Principal Investigator
      NEMOTO Masami
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Jikei University School of Medicine
  •  Design and construction of cell device for inslin release to control of glycemia

    • Principal Investigator
      AIZAWA Masuo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Tokyo Institute of Technology
  •  Gene Therapy for diabetes mellitus with non-endocrine cellsPrincipal Investigator

    • Principal Investigator
      SASAKI Takashi
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Jikei University School of Medicine
  •  Genomic imprinting and instability in IDDMPrincipal Investigator

    • Principal Investigator
      SASAKI Takashi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Jikei University School of Medicine
  •  日本人IDDMの遺伝におけるgenetic imprinting

    • Principal Investigator
      TAJIMA Naoko
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Jikei University School of Medicine

All 2018 2017 2016 2015 2014 2007 2006 2000

All Journal Article Presentation

  • [Journal Article] SGLT2 inhibitor-induced changes in body composition and simultaneous changes in metabolic profile: 52-week prospective LIGHT Study with Luseogliflozin.2018

    • Author(s)
      Sasaki T, Sugawara M, Fukuda M.
    • Journal Title

      J Diabetes Investig.

      Volume: 9 Issue: 1 Pages: 108-117

    • DOI

      10.1111/jdi.12851

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Journal Article] Sodium-glucose cotransporter-2 inhibitor luseogliflozin added to glucagon-like peptide 1 receptor agonist liraglutide improves glycemic control with bodyweight and fat mass reductions in Japanese patients with type 2 diabetes: A 52-week, open-label, single-arm study.2018

    • Author(s)
      Seino Y, Yabe D, Sasaki T, Fukatsu A, Imazeki H, Ochiai H, Sakai S.
    • Journal Title

      J Diabetes Investig.

      Volume: 9 Issue: 2 Pages: 338-340

    • DOI

      10.1111/jdi.12694

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Journal Article] Pharmacokinetics and Pharmacodynamics of Luseogliflozin, a Selective SGLT2 Inhibitor, in Japanese Patients With Type 2 Diabetes With Mild to Severe Renal Impairment.2018

    • Author(s)
      Samukawa Y, Haneda M, Seino Y, Sasaki T. Fukatsu A, Kubo Y, Sato Y, Sakai S.
    • Journal Title

      Clin Pharmacol Drug Dev

      Volume: 7 Issue: 8 Pages: 820-828

    • DOI

      10.1002/cpdd.456

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Journal Article] Sarcopenia, frailty circle and treatment with sodium-glucose cotransporter 2 inhibitors.2018

    • Author(s)
      Takashi Sasaki
    • Journal Title

      J Diabetes Investig

      Volume: 10 Issue: 2 Pages: 193-195

    • DOI

      10.1111/jdi.12966

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Journal Article] Efficacy and safety of luseogliflozin added to insulin therapy in Japanese patients with type 2 diabetes: a multicenter, 52-week, clinical study with a 16-week, double-blind period and a 36-week, open-label period.2018

    • Author(s)
      Seino Y, Sasaki T, Fukatsu A, Imazeki H, Ochiai H, Sakai S.
    • Journal Title

      Curr Med Res Opin

      Volume: 34 Issue: 6 Pages: 981-994

    • DOI

      10.1080/03007995.2018.1441816

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Journal Article] Sodium-glucose cotransporter 2 inhibitor-induced changes in body composition and simultaneous changes in metabolic profile: 52-week prospective LIGHT (Luseogliflozin: the Components of Weight Loss in Japanese Patients with Type 2 Diabetes Mellitus) Study.2018

    • Author(s)
      Takashi Sasaki, Sugawara M, Fukuda M.
    • Journal Title

      J Diabetes Investig

      Volume: 10

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Journal Article] SGLT2阻害薬ルセオグリフロジンの高齢2型糖尿病患者における安全性と有効性の検討 高齢者における特定使用成績調査(最終報告)2017

    • Author(s)
      黒瀬 健, 稲垣暢也, 深津敦司, 佐々木 敬, 北島壮一, 清野 裕
    • Journal Title

      薬理と治療

      Volume: 45 Pages: 559-569

    • Data Source
      KAKENHI-PROJECT-26461346
  • [Journal Article] SGLT2阻害薬によるケトン体の上昇の意味は? 心血管イベントのリスク減少機序としては、高ケトンよりも血圧低下、体液減少、交感神経の過緊張の解除が有力2017

    • Author(s)
      佐々木 敬
    • Journal Title

      日本医事新報

      Volume: 4882 Pages: 62-63

    • Data Source
      KAKENHI-PROJECT-26461346
  • [Journal Article] Modified Western blotting for insulin and other diabetes-associated peptide hormones.2017

    • Author(s)
      Okita N, Higami Y, Fukai F, Kobayashi M, Mitarai M, Sekiya T, Sasaki T.
    • Journal Title

      Sci Rep

      Volume: 7:6949 Issue: 1 Pages: 1-11

    • DOI

      10.1038/s41598-017-04456-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461346, KAKENHI-PROJECT-17H02179
  • [Journal Article] 日本人2型糖尿病患者に対するSGLT2阻害薬ルセオグリフロジンの増量効果の検討 国内第III相52週投与試験の併合解析2017

    • Author(s)
      佐々木 敬, 玉置 浩之, 坂井 荘一, 寒川 能成
    • Journal Title

      Progress in Medicine

      Volume: 37 Pages: 769-776

    • Data Source
      KAKENHI-PROJECT-26461346
  • [Journal Article] Efficacy and Safety of the SGLT2 Inhibitor Luseogliflozin in Japanese Patients With Type 2 Diabetes Mellitus Stratified According to Baseline Body Mass Index: Pooled Analysis of Data From 52-Week Phase III Trials2016

    • Author(s)
      Soichi Sakai, Kohei Kaku, Yutaka Seino, Nobuya Inagaki, Masakazu Haneda, Takashi Sasaki, Atsushi Fukatsu, Haruka Kakiuchi, Yoshishige Samukawa
    • Journal Title

      Clinical Therapeutics

      Volume: 38 Issue: 4 Pages: 843-862

    • DOI

      10.1016/j.clinthera.2016.01.017

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Journal Article] High-throughput screening of small interfering ribonucleic acid identifies important modulators in islet dysfunction and apoptosis.2015

    • Author(s)
      Masami Nemoto, Takashi Sasaki
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 6 Issue: 4 Pages: 390-392

    • DOI

      10.1111/jdi.12283

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Journal Article] Epigenetics: Reprogrammable interface of the genome and environments.2014

    • Author(s)
      Takashi Sasaki
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 5 Issue: 2 Pages: 119-120

    • DOI

      10.1111/jdi.12150

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Journal Article] Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes:a case control study with multi-slice computed tomography2007

    • Author(s)
      根本 昌実、佐々木 敬、藤本 啓、比企 能人, ほか
    • Journal Title

      Cardiovascular diabetology 6

      Pages: 23-29

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590948
  • [Journal Article] In vitro and Pathological Investigations of MODY5 with the R276X-HNF1β (TCF2) Mutation2007

    • Author(s)
      Fujimoto, K., Sasaki, T., et. al.
    • Journal Title

      Endocrine Journal 54

      Pages: 757-764

    • NAID

      10020092977

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590948
  • [Journal Article] In vitro and Pathological Investigations of MODY5 with the R276X-HNF1β (TCF2) Mutation2007

    • Author(s)
      藤本 啓、佐々木 敬、根本 昌実、比企 能人, ほか
    • Journal Title

      Endocr J 54

      Pages: 757-764

    • NAID

      10020092977

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590948
  • [Journal Article] In vitro and Pathological Investigations of MODY5 with the R276X-HNF1β(TCF2)Mutation2007

    • Author(s)
      藤本 啓、佐々木 敬、根本 昌実、比企 能人, ほか
    • Journal Title

      Endocr J 54

      Pages: 757-764

    • NAID

      10020092977

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590948
  • [Journal Article] Genetic association of glutathione peroxidase-1 with coronary Artery calcification in type 2 diabetes : a case control study with multi-slice computed tomography2007

    • Author(s)
      Nemoto, M., Sasaki, T., et. al.
    • Journal Title

      Cardiovascular Diabetology 6

      Pages: 23-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590948
  • [Journal Article] 治療へのアプローチ、インスリン製剤-開発と治療法の進歩2000

    • Author(s)
      佐々木 敬
    • Journal Title

      日本内科学会雑誌 89

      Pages: 1544-1550

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12358015
  • [Presentation] SGLT2阻害薬ルセオグリフロジンの長期使用における安全性と有用性の検討 長期使用に関する特定使用成績調査(中間報告)2017

    • Author(s)
      黒瀬 健, 稲垣暢也, 深津敦司, 佐々木 敬, 笠井良樹, 北島壮一, 清野 裕
    • Organizer
      第60回日本日本糖尿病学会学術集会(5月、名古屋)
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Presentation] 健常者における麦飯と主菜の併用による食後血糖上昇の検討2017

    • Author(s)
      杉原聡子, 石崎知子, 早乙女 恵, 細田暁彦, 種村陽子, 篠田良行, 小川篤美, 赤石定典, 湯浅 愛, 小沼宗大, 濱 裕宣, 佐々木 敬, 吉田 博
    • Organizer
      第39回日本臨床栄養学会総会(10月、幕張)
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Presentation] Western blottingのプロトコール改変によるinsulin及び糖尿病関連ペプチドホルモンの定量検出の実現2017

    • Author(s)
      沖田直之, 樋上賀一, 深井文雄, 小林正樹, 御手洗光来, 関谷剛男, 佐々木 敬
    • Organizer
      第60回日本日本糖尿病学会学術集会(5月、名古屋)
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Presentation] 健常者における麦飯と主菜の併用による食後血糖上昇の検討2017

    • Author(s)
      小川篤美, 石崎知子, 細田暁彦, 種村陽子, 篠田良行, 赤石定典, 湯浅 愛, 小沼宗大, 濱 裕宣, 佐々木 敬, 吉田 博
    • Organizer
      第12回日本機能性食品医用学会総会(12月、京都)
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Presentation] リラグルチド単独で血糖コントロール不十分な2型糖尿病患者へのルセオグリフロジン追加投与時の長期安全性・有効性に関する検討2017

    • Author(s)
      矢部大介, 佐々木 敬, 深津敦司, 今関寿恵, 落合秀和, 坂井荘一, 清野 裕
    • Organizer
      第60回日本日本糖尿病学会学術集会(5月、名古屋)
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Presentation] SGLT2阻害薬による治療に伴う体組成の変化と代謝の連関 52週間の前向き研究LIGHT Study2017

    • Author(s)
      佐々木 敬, 菅原正弘, 福田正博
    • Organizer
      第60回日本日本糖尿病学会学術集会(5月、名古屋)
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Presentation] SGLT2阻害薬による治療に伴う体組成変化と代謝の連関 LIGHT study2017

    • Author(s)
      佐々木 敬
    • Organizer
      第31回日本臨床内科医学会(10月、大阪)
    • Invited
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Presentation] 日本人1型糖尿病家系における非HLA遺伝子の連鎖と両親からの遺伝様式の検討2017

    • Author(s)
      根本昌実, 溝渕杏子, 佐々木 敬, 藤本 啓, 比企能人, 大橋十也, 宇都宮一典
    • Organizer
      第21回日本適応医学会学術集会(12月、東京)
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Presentation] 教育講演: β細胞におけるインスリン分泌の制御機構2015

    • Author(s)
      佐々木 敬
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      山口
    • Year and Date
      2015-05-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Presentation] PKCdelta is a key regulator of palmitate-induced beta cell death.2015

    • Author(s)
      Masatsugu Shiozaki ,Kei Fujimoto, Takashi Sasaki, Yoshida K, Kazunori Utsunomiya
    • Organizer
      51st European Association for the Study of Diabetes (EASD) annual meeting
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2015-09-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461346
  • [Presentation] In vivo gene delivery by pancreatic direct injection of rAAV8 vector is efficient to the injured islets2007

    • Author(s)
      Hiki, Y., Sasaki, T., et. al.
    • Organizer
      Scientific sessions of 67th American Diabetes Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2007-06-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590948
  • [Presentation] In vivo gene delivery by pancreatic direct injection of rAAV8 vector is efficient to the injured islets2007

    • Author(s)
      比企 能人、佐々木 敬、根本 昌実、藤本 啓, ほか
    • Organizer
      第67回米国糖尿病学会
    • Place of Presentation
      Chicago,IL,USA
    • Year and Date
      2007-06-25
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590948
  • [Presentation] Genetic association of Pro197Leu allele at GPX-1 gene to coronary artery calcification suggests importance of shifted redox balance for development of atherosclerosis in diabetes2006

    • Author(s)
      根本 昌実、佐々木 敬、藤本 啓、比企 能人, ほか
    • Organizer
      第42回ヨーロッパ糖尿病学会
    • Place of Presentation
      Copenhagen,Denmark
    • Year and Date
      2006-09-15
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590948
  • [Presentation] Genetic association of Pro 197Leu allele at GPX-1 gene to coronary artery calcification suggests importance of shifted redox balance for development of athero-sclerosis in diabetes2006

    • Author(s)
      Nemoto, M., Sasaki, T., et. al.
    • Organizer
      42nd Annual Meeting of the European Association for the Study of Diabetes
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2006-09-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590948
  • 1.  NEMOTO Masami (10281396)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 9 results
  • 2.  TAJIMA Naoko (70112836)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  FUJIMOTO Kei (40372974)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 4.  AIZAWA Masuo (00016742)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  YANAGIDA Yasuko (10282849)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  OHNO Tsuneya (60147288)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  NAKAMURA Mariko (40237433)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  Kouno Midori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  Yoshizawa Yukio
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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