NAKAUMA Hideki 中熊秀喜

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NAKAKUMA Hideki 中熊秀喜

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Researcher Number	90207746
Other IDs
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Affiliation (based on the past Project Information) *help	2009 – 2010: Wakayama Medical University, 医学部, 教授 2006 – 2007: 和歌山県立医科大学, 医学部, 教授 2003: Wakayama Medical University, Prof, 教授 2003: Wakayama Medical University, Department of Hematology and Transfusion Service, Professor, 輸血・血液疾患治療部, 教授 2000 – 2002: KUMAMOTO UNIVERSITY SCHOOL OF MEDICINE JYOKYOJU (ASSOCIATE PROFESSOR), 医学部, 助教授 1995 – 1999: 熊本大学, 医学部, 講師 1991 – 1993: 熊本大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Hematology / Hematology / Biological Sciences Except Principal Investigator Hematology / Hematology
Keywords	Principal Investigator 発作性夜間血色素尿症 / 増殖異常 / B / MICA / ULBP / NKG2D / PNH / HPRT / paroxysmal nocturnal hemoglobinuria / 骨髄細胞 … More / Tリンパ球 / 遺伝子変異 / 造血不全 / 溶血 / ガングリオシド / stress-inducible proteins / NKG2D ligands / bone marrow failure / aplastic anemia / ストレス蛋白 / NKG2Dリガンド / 特発性造血障害 / 再生不良性貧血 / bone marrow cells / T cells / mutations / HPRT遺伝子 / T細胞 / growth abnormality / stem cell / 遺伝子 / 腫瘍性増殖 / 幹細胞 / 造血幹細胞 / T cell lines / GlcNAc / GPI anchor / Hemolysis / 株細胞 / 糖鎖異常 / GPIアンカー / 造血障害 / 発作性夜間ヘモグロビン尿症 / 1-8D遺伝子 / インターフェロン / 白血病 / 巨核球 / ジーントラップ / 造血関連遺伝子 / 病態遺伝子 / 前白血病 / N1 アセチルトランスフェラーゼ / ポリミアン / 転写因子 / 発作性夜間血色色素尿症 / アポトーシス / 遺伝子サブトラクション / 培養細胞 / 骨髄移植 / 骨髄幹細胞 / CD34陽性細胞 / SCIDマウス / 増殖機構 / 糖鎖 / 臨床病型 / ATL / 成人T細胞白血病 … More Except Principal Investigator PNH / 発作性夜間血色素尿症 / HPRT / PIG-A / 造血幹細胞 / 溶血性貧血 / mutation / aplastic anemia / 骨髄異形成症候群 / 発作性夜間血色素尿 / 遺伝子変異 / 遣伝子変異 / 再生不良性貧血 / random ribozyme library / maxizyme / GPI anchor deficient K562 cells / VSV-G pseudotype lentivirus vector / gene transduction / gene therapy / VSV-Gシュードタイプレンチウィルスベクター / K562白血病細胞 / 水疱性口内炎ウィルスG蛋白 / マウス白血病ウィルスベクター / SCID / NOD / Musashi1 / K562細胞株 / PIG-A遺伝子 / GFP遺伝子 / 臍帯血CD34細胞 / ランダムリボザイムライブラリー / マキシザイム / GPIアンカー欠失K562細胞 / VSV-Gシュードタイプレンチウイルスベクター / 遺伝子導入 / 遺伝子治療 / HPRT gene / Monosomy 7 / Genetic instability / Hemolytic anemia / Paroxysmal nocturnal hemoglobinuria / マイクロサテライト / HPRT遺伝子 / モノソミー7 / 遺伝子不安定性 / 骨髄 / チロシンキナーゼ / 補体活性化 / レクチン / 隠蔽抗原 / 補体 / 溶血発作 / 発作性夜間血色素尿症(PNH) Less

発作性夜間ヘモグロビン尿症の関連の特発性造血障害の分子病態の解明Principal Investigator
- Principal Investigator
  
  中熊秀喜
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Wakayama Medical University
造血幹細胞と幹細胞ニッチの相互作用における軸索ガイダンス分子の機能の解明
- Principal Investigator
  
  松岡広
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Wakayama Medical University
Molecular pathogenesis of bone marrow failure as a major cause of death in paroxysmal nocturnal hemoglobinuriaPrincipal Investigator
- Principal Investigator
  
  NAKAUMA Hideki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Wakayama Medical University
Elucidation of pathogenic genes for abnormal hematopoiesis and the development of gene therapy in paroxysmal nocturnal hemoglobinuria
- Principal Investigator
  
  TANI Kenzaburo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Molecular mechanism of emergence of clonal disorders in aplastic anemia
- Principal Investigator
  
  HORIKAWA Kentaro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
発作性夜間血色素尿症患者における白血病の好発の機序の解明Principal Investigator
- Principal Investigator
  
  中熊秀喜
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Molecular pathogenesis of paroxysmal nocturnal hemoglobinuria as a preleukemiaPrincipal Investigator
- Principal Investigator
  
  NAKAKUMA Hideki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
発作性夜間血色素尿症(PNH)クローンの腫瘍性増殖機構Principal Investigator
- Principal Investigator
  
  中熊秀喜
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kumamoto University
THE ETIOLOGY OF SOMATIC MUTATIONS IN PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
- Principal Investigator
  
  KAWAGUCHI Tatsuya
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  KUMAMOTO UNIVERSITY
発作性夜間血色素尿症(PNH) クローンの腫瘍性増殖機構Principal Investigator
- Principal Investigator
  
  中熊秀喜
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kumamoto University
ジーントラップ法による新しい造血関連遺伝子の同定Principal Investigator
- Principal Investigator
  
  中熊秀喜
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Growth abnormality of paroxysmal nocturnal hemoglobinuria stem cellPrincipal Investigator
- Principal Investigator
  
  NAKAKUMA Hideki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
発作性夜間血色素尿症(PNH)クローンの腫瘍性増殖機構.Principal Investigator
- Principal Investigator
  
  中熊秀喜
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
発作性夜間血色素尿症(PNH)クローンの腫瘍性増殖機構の解析Principal Investigator
- Principal Investigator
  
  中熊秀喜
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
発作性夜間血色素尿症(PNH)における骨髄造血不全の発生機構Principal Investigator
- Principal Investigator
  
  中熊秀喜
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
発作性夜間血色素尿症(PNH)クローンの腫瘍性増殖機構の解析Principal Investigator
- Principal Investigator
  
  中熊秀喜
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
発作性夜間血色素尿症(PNH)の溶血発作に関する血管内補体活性化機構
- Principal Investigator
  
  川口辰哉
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
溶血性貧血における赤血球膜ガングリオシドの発現異常Principal Investigator
- Principal Investigator
  
  中熊秀喜
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
Molecular mechanism of abnormal hemolysis in paroxysmal nocturnal hemoglobinuriaPrincipal Investigator
- Principal Investigator
  
  NAKAKUMA Hideki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
成人T細胞白血病における細胞膜ガングリオシド発現解析と臨床応用Principal Investigator
- Principal Investigator
  
  中熊秀喜
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University

All 2010 2009 2007

All Journal Article Presentation

[Journal Article] 発作性夜間ヘモグロビン尿症(PNH)～最新の臨床と研究～2010
- Author(s)
  中熊秀喜
- Journal Title
  
  日本検査血液学会雑誌
  
  Volume: 11 Pages: 336-343
- Data Source
  KAKENHI-PROJECT-21591215
[Journal Article] 発作性夜間血色素尿症(PNH)2010
- Author(s)
  中熊秀喜
- Journal Title
  
  細胞
  
  Volume: 42 Pages: 274-277
- Data Source
  KAKENHI-PROJECT-21591215
[Journal Article] 発作性夜間血色素尿症2009
- Author(s)
  中熊秀喜
- Journal Title
  
  総合臨床 58
  
  Pages: 1736-1740
- NAID
  10018863979
- Data Source
  KAKENHI-PROJECT-21591215
[Journal Article] New insights into molecular pathogenesis of bone marrow failure in paroxysmal nocturnal hemoglogbinuria2007
- Author(s)
  Kawaguchi T, Nakakuma H
- Journal Title
  
  International Journal of Hematology 86
  
  Pages: 27-32
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591081
[Journal Article] New insights into molecular pathogenesis of bone marrow failure in paroxysmal nocturnal hemoglobinuria2007
- Author(s)
  Kawaguchi T, Nakakuma, H
- Journal Title
  
  Int J Hematol 86
  
  Pages: 27-32
- NAID
  10018515469
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591081
[Presentation] PNHおよび関連疾患におけるNKG2D介在性の造血障害2007
- Author(s)
  花岡伸佳、中熊秀喜, 他5名
- Organizer
  第69回日本血液学会・第49回日本臨床血液学会合同総会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591081

1. KAWAGUCHI Tatsuya (50244116)

# of Collaborated Projects: 11 results

# of Collaborated Products: 2 results
2. HORIKAWA Kentaro (40322309)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. TANI Kenzaburo (00183864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MUTA Hiromi (40325478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ASANO Shigetaka (50134614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SONOKI Takashi (30382336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松岡広 (50418878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 日高道弘

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKAUMA Hideki 中熊 秀喜

NAKAKUMA Hideki 中熊 秀喜

Research Projects

Research Products

Co-Researchers

発作性夜間ヘモグロビン尿症の関連の特発性造血障害の分子病態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

造血幹細胞と幹細胞ニッチの相互作用における軸索ガイダンス分子の機能の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pathogenesis of bone marrow failure as a major cause of death in paroxysmal nocturnal hemoglobinuriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of pathogenic genes for abnormal hematopoiesis and the development of gene therapy in paroxysmal nocturnal hemoglobinuria

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of emergence of clonal disorders in aplastic anemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

発作性夜間血色素尿症患者における白血病の好発の機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular pathogenesis of paroxysmal nocturnal hemoglobinuria as a preleukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

発作性夜間血色素尿症(PNH)クローンの腫瘍性増殖機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

THE ETIOLOGY OF SOMATIC MUTATIONS IN PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

発作性夜間血色素尿症(PNH) クローンの腫瘍性増殖機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ジーントラップ法による新しい造血関連遺伝子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Growth abnormality of paroxysmal nocturnal hemoglobinuria stem cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

発作性夜間血色素尿症(PNH)クローンの腫瘍性増殖機構.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

NAKAUMA Hideki 中熊秀喜

NAKAKUMA Hideki 中熊秀喜