NAGASAWA Hideko 永澤秀子

… Alternative Names

永沢秀子ナガサワヒデコ

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Researcher Number	90207994
Other IDs
External Links
Affiliation (Current)	2025: 岐阜薬科大学, 薬学部, 特命教授
Affiliation (based on the past Project Information) *help	2024: 岐阜薬科大学, 薬学部, 特命教授 2006 – 2023: 岐阜薬科大学, 薬学部, 教授 2006: 岐阜薬科大学, 創薬化学, 教授 2002 – 2005: 徳島大学, 工学部, 助教授 1998 – 1999: 徳島大学, 工学部, 講師 … More 1996: 慶應義塾大学, 医学部, 助手 1994: 慶應義塾大学, 医学部, 助手 1989 – 1990: Keio Univ. Sch. of Med., Instr., 医学部, 助手 1988 – 1989: 慶応義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Bioorganic chemistry / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Biological Sciences Except Principal Investigator 医薬分子機能学 / Physical pharmacy / Digestive surgery … More / Complex systems / Basic Section 52040:Radiological sciences-related / Tumor biology / Chemical pharmacy / Biological pharmacy / Obstetrics and gynecology / Tumor biology / Drug development chemistry Less
Keywords	Principal Investigator がん微小環境 / 酸化ストレス / がん / フェロトーシス / 鉄代謝 / 血管新生阻害 / 低酸素 / ホウ素中性子捕捉療法 / 抗ミトコンドリア治療 / がん治療 … More / がん治療薬 / エネルギー代謝 / HIF-1α / hypoxic cytotoxin / ホウ素キャリア / 合成致死 / 小胞体ストレス / 二価鉄 / HIF-1 / VEGF / 鉄中毒 / プロドラッグ / ras変異がん / 鉄・活性酸素中毒がん / フロー合成 / がんエネルギー代謝 / 鉄硫黄タンパク質 / MiNT / 鉄・ROS中毒 / ミトコンドリア / 10Bキャリア / アミノ酸トランスポーター / がん代謝 / ホウ素クラスター / LAT1 / L型アミノ酸トランスポーター / グルタミン中毒 / 鉄レドックス変動 / 酸化ストレス耐性解除 / 創薬 / 微小環境 / 蛍光イメージング / 小胞体ストレス応答 / apoptosis / hypoxia / angiogenic inhibition / p53 / 低酸素細胞 / アポトーシス / ハイポキシア / HIFL-1α / 腫瘍 / 化学的分子送達システム / 血管新生阻害作用 / がん幹細胞 / ERストレス / 血管新生 / 創薬化学 / 低栄養 / 環状イミド誘導体 / 抗酸化作用 / 構造活性相関 / 血管新生阻害剤 / 医薬分子設計 / 分子設計 / ニトロイミダゾール / ニトロ芳香族化合物 / 近赤外蛍光プローブ / 新生血管 / インテグリン / ボロンクラスタ / 能動送達 / 中性子捕捉療法(BNCT) / RGD / インテグリン受容体 / ボロンキャリア / 中性子捕捉療法 / 医薬品分子設計 / 3'非翻訳領域 / カルシウム流 / クローニング / differential hybridization / ペンチレンテトラゾール / 柴胡桂枝湯加芍薬 / けいれん / てんかん … More Except Principal Investigator 低酸素 / 中性子捕捉療法 / 休止期腫瘍細胞 / 腫瘍内微小環境 / 転移 / TX-1877 / TX-2068 / イメージング / 分析科学 / ティラパザミン / 低温度温熱処置 / 腫瘍不均一性 / CBE値 / 放射線 / 外科 / 癌 / ケージド / 光制御 / ケージド化合物 / ケミカルバイオロジー / 放射線損傷からの回復現象 / 低酸素細胞毒 / 低酸素誘導因子 / 放射線障害からの回復現象 / 腫瘍不均一性, / p53 status / 化合物生物学的効果比 / ホウ素中性子捕捉療法 / 温熱治療 / 癌幹細胞性 / 遠隔転移抑制能 / 急性低酸素領域 / ピモニダゾール / 低グルコース環境 / メトフォルミン / HIF-1α / ゲノム編集技術 / 転移能抑制 / 局所腫瘍制御 / がん微小環境 / 線量率効果 / 硼素中性子捕捉療法 / 放射線治療生物学 / ゲノム改変操作 / 薬学 / 硫化水素 / 高感度化 / シグナル伝達 / 蛍光 / yeast / ambrosanolides / common chiral synthon / enzyme-catalyzed asymmctric hydrolysis / microbial asymmctric reduction / santanolides / cudesmanolides / alpha-methylene-gamma-lactone / プソイドグアイアノリド / オイデスマノリド / セスキテルペノイド / キラルシントン / 生物的不斉導入 / Rodotorula / Tricosporon / イースト菌 / 合成鍵中間体 / ambrosic acid / pulchellin C類 / Lipase Amano P / Hansenula anomala / オイデスマノイド / ambrosanoids / lipases / 11-dehydrosantanolides / Rhodotorula rubula / キラル合成素子 / 微生物学的不斉反応 / eudesmanoids / 酵母 / アンブロサノシド / サンタノリド / 共通キラ-ル鍵中間体 / 酵素的不斉加水分解 / オイデスマノイドセスキテルペン / 微生物的不斉還元 / αーメチレンーγーラクトン / Surgery / Metastasis / Anviogenesis / Sensitizer / Sensitivity / Hypoxia / Radiation / Colorectal cancer / 血管新生 / 増感剤 / 感受性 / 大腸癌 / N-Acetylgalactosamine / Hypoxia Orientation / Macrophage / Hypoxic Cell Radiosensitizer / TX-2073 / GcMAF / 貪食活性 / N-アセチルガラクトサミン / 低酸素指向性 / マクロファージ / 低酸素細胞放射線増感剤 / anticancer drug / molecular design / imnmnopotentiator / enzyme inhibitor / α-N-acetyl gahctosamintdase / がん細胞 / 制がん剤分子設計 / 阻害活性 / α-N-アセチルガラクトサミニダーゼ / 制がん剤 / 分子設計 / 免疫賦活剤 / 酵素阻害剤 / -N-アセチルガラクトサミニダーゼ / Misonidazole / Pharmacokinetics / Glutatione depletion / 2-Nitroimidazole / Hydroxamic acid / KIH-802 / Radiosensitizer / Hypoxic cell / 卵巣癌 / インビボ / がん / 非侵襲性 / 低侵襲性 / 高感度 / 化学発光 / サイクロデキストリン / インテグリンαvβ3受容体 / 中性子捕捉療法(BNCT) / L-para-boronophenylalanin-10B / sodium borocaptate-10B(BSH) / 中性子捕捉反応 / 加速炭素イオン線 / 分割ウォルトマニン投与 / ウォルトマニン / 酸素化休止期腫瘍細胞分画 / 急性低酸素細胞分画 / ベバシツマブ / 遠隔転移制御 / 腫瘍血管正常化現象 / 癌幹細胞 / 酸素化休止期腫瘍細胞 / 慢性低酸素 / 急性低酸素 / 膵臓癌 / 有機化学 / 鶏胚漿尿膜 / FTY720 / ポリイン / キラリティー / スワインソニン / ブレフェルジン / ナノアセンブリー / 構造-活性相関 / クロロキン / ピペラジン / 薬剤耐性 / マラリア / 生物学的応答修飾剤 / 分化誘導 / 放射線増感剤剤 / 低酸素性細胞 / BRM / differentiation / radiosensitizer / hypoxic cell Less

Therapeutic Strategies Targeting Iron Addiction for KRAS Mutation Refractory CancerPrincipal Investigator
- Principal Investigator
  
  永澤秀子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Gifu Pharmaceutical University
Drug Discovery Targeting Mitochondrial Iron Sulfur Protein MiNT, a Novel Molecular Target for Anti-Mitochondrial TherapyPrincipal Investigator
- Principal Investigator
  
  Hideko Nagasawa
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Gifu Pharmaceutical University
Interrelationship analysis of the characteristics of quiescent tumor cells with tumor heterogeneity and cancer stem cell nature, referring to application to cancer therapy
- Principal Investigator
  
  増永慎一郎
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Osaka Metropolitan University
  Osaka Prefecture University
  Kyoto University
タンパク質の非平衡状態構造解析を可能にするケミカル光制御法の開発
- Principal Investigator
  
  清中茂樹
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Nagoya University
Development of novel boron carrier utilizing amino acid transporters specific for glutamine addiction of cancer cellsPrincipal Investigator
- Principal Investigator
  
  Nagasawa Hideko
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Gifu Pharmaceutical University
Development of tumor-selective drug based on synthetic lethal strategy by overcoming oxidative stress tolerance of cancerPrincipal Investigator
- Principal Investigator
  
  Nagasawa Hideko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu Pharmaceutical University
Development of highly sensitive fluorescent probes with chain amplification of hydrogen sulfide signaling
- Principal Investigator
  
  Okuda Kensuke
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kobe Pharmaceutical University
  Gifu Pharmaceutical University
An attempt to achieve both controlling local tumors and repressing distant metastases through exploiting analytical findings concerning characteristics of intratumor microenvironment
- Principal Investigator
  
  Masunaga Shin-ichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kyoto University
Development of chemical drug delivery system using pepducin for boron carriers of BNCTPrincipal Investigator
- Principal Investigator
  
  Nagasawa Hideko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu Pharmaceutical University
Development of new treatment in ovarian cancer - HIF inhibitor to overcome the anti-angiogenic drug resistance
- Principal Investigator
  
  SUZUKI NORIKO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Gifu University
The study of drug development targeting the stress response in the tumor microenvironment for the treatment of refractory cancerPrincipal Investigator
- Principal Investigator
  
  HIDEKO Nagasawa
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu Pharmaceutical University
The development study of highly sensitive chemiluminescent probe for tumor hypoxia in vivo imaging
- Principal Investigator
  
  OKUDA Kensuke
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Gifu Pharmaceutical University
Exploration and exploit of intratumor microenvironment for both controlling local tumors and reducing distant metastatic potential
- Principal Investigator
  
  MASUNAGA Shin-ichiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kyoto University
Molecular design and chemical genetic approach of bio-probe for anti-angiogenic therapyPrincipal Investigator
- Principal Investigator
  
  NAGASAWA Hideko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu Pharmaceutical University
がん幹細胞のケミカルジェネティクスを指向する低酸素特異的蛍光バイオプローブの創製Principal Investigator
- Principal Investigator
  
  永澤秀子
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu Pharmaceutical University
Design and synthesis of active targeting boron carriers to tumor vascularization for boron neutron capture therapyPrincipal Investigator
- Principal Investigator
  
  NAGASAWA Hideko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu Pharmaceutical University
低酸素環境を標的とした膵臓癌に対する新たな治療法の開発
- Principal Investigator
  
  MIYAKE Kentaro
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokushima
Development of new chemoradiosensitizing method for colorectal cancer
- Principal Investigator
  
  NISHIOKA Masanori
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokushima
標的分子との空間的相互作用のコントロールを指向したナノアセンブリー薬剤の分子設計
- Principal Investigator
  
  HORI Hitoshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
Design of hypoxic cell radiosensitizer utilized for hypoxia orientation of macrophage
- Principal Investigator
  
  HORI Hitoshi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokushima
Molecular design of hypoxia-targeting anticancer drug.Principal Investigator
- Principal Investigator
  
  NAGASAWA Hideko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  The University of Tokushima
Molecular design of anticancer drug, α-NaGalase inhibitors for immunopotentiation
- Principal Investigator
  
  HORI Hitoshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokushima
マラリア原虫のクロロキン耐性を消去する薬剤の開発と作用機構に関する研究
- Principal Investigator
  
  竹内勤
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Keio University
新規生物活性物質探索系の構築をめざす柴胡桂枝湯の抗癲癇作用機構の逆転遺伝学的解析Principal Investigator
- Principal Investigator
  
  永沢秀子
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Keio University
生物学的応答修飾の機構を介する放射線抗腫瘍作用の化学的増感
- Principal Investigator
  
  INAYAMA Seiichi
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Keio University
放射線生物学的修飾物質の新規開発と実用化に関する研究
- Principal Investigator
  
  稲山誠一
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Keio University
Synthetic Studies of Cyclic Sesquiterpenoids Using Microbiologically Modified Chiral Synthons
- Principal Investigator
  
  INAYAMA Seiichi
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Keio University

[Book] 酸化ストレスの医学　28. 酸化ストレス適応応答を標的としたがん治療創薬2014
- Author(s)
  永澤秀子
- Total Pages
  456
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-24390029
[Book] ハイポキシアを標的とした抗癌剤(実験医学)2009
- Author(s)
  宇都義浩, 中田栄司, 永澤秀子, 堀均
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19590102
[Book] 低酸素標的薬2007
- Author(s)
  永澤秀子
- Publisher
  実験医学、用度者
- Data Source
  KAKENHI-PROJECT-19590102
[Book] 岐阜県病院薬剤師会雑誌2007
- Author(s)
  永澤秀子
- Publisher
  岐阜県病院薬剤師会
- Data Source
  KAKENHI-PROJECT-19590102
[Book] 実験医学2007
- Author(s)
  永澤秀子
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19590102
[Journal Article] Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress2023
- Author(s)
  Tsuji Mieko、Taira Haruno、Udagawa Taro、Aoki Tatsuya、Hirayama Tasuku、Nagasawa Hideko
- Journal Title
  
  Chemical Communications
  
  Volume: 69
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19H05778
[Journal Article] Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress2023
- Author(s)
  Tsuji Mieko、Taira Haruno、Udagawa Taro、Aoki Tatsuya、Hirayama Tasuku、Nagasawa Hideko
- Journal Title
  
  Chemical Communications
  
  Volume: 41 Issue: 44 Pages: 6706-6709
- DOI
  10.1039/d3cc01192e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19383
[Journal Article] Molecular Imaging of Labile Heme in Living Cells Using a Small Molecule Fluorescent Probe2022
- Author(s)
  Kawai Kanta、Hirayama Tasuku、Imai Haruka、Murakami Takanori、Inden Masatoshi、Hozumi Isao、Nagasawa Hideko
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 144 Issue: 9 Pages: 3793-3803
- DOI
  10.1021/jacs.1c08485
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05767, KAKENHI-PLANNED-19H05778, KAKENHI-PUBLICLY-20H05515, KAKENHI-PUBLICLY-22H04818
[Journal Article] Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment2021
- Author(s)
  Sakai Takayuki、Matsuo Yoshiyuki、Okuda Kensuke、Hirota Kiichi、Tsuji Mieko、Hirayama Tasuku、Nagasawa Hideko
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 4852-4852
- DOI
  10.1038/s41598-021-83708-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09339, KAKENHI-PROJECT-20K09210, KAKENHI-PROJECT-19H03352, KAKENHI-PROJECT-20H03776, KAKENHI-PROJECT-18K08877, KAKENHI-PROJECT-19K07035
[Journal Article] A Golgi-targeting fluorescent probe for labile Fe(ii) to reveal an abnormal cellular iron distribution induced by dysfunction of VPS352019
- Author(s)
  Hirayama Tasuku、Inden Masatoshi、Tsuboi Hitomi、Niwa Masato、Uchida Yasuhiro、Naka Yuki、Hozumi Isao、Nagasawa Hideko
- Journal Title
  
  Chemical Science
  
  Volume: 10 Issue: 5 Pages: 1514-1521
- DOI
  10.1039/c8sc04386h
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08311, KAKENHI-PROJECT-16H05102, KAKENHI-PROJECT-18H02110, KAKENHI-PROJECT-17K19207
[Journal Article] Design, Synthesis, and Evaluation of Lipopeptide Conjugates of Mercaptoundecahydrododecaborate for Boron Neutron Capture Therapy2019
- Author(s)
  Isono Aoi、Tsuji Mieko、Sanada Yu、Matsushita Akari、Masunaga Shinichiro、Hirayama Tasuku、Nagasawa Hideko
- Journal Title
  
  ChemMedChem
  
  Volume: 14 Issue: 8 Pages: 823-832
- DOI
  10.1002/cmdc.201800793
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05102, KAKENHI-PROJECT-15H04295, KAKENHI-PROJECT-19K08171
[Journal Article] Organelle-specific analysis of labile Fe(ii) during ferroptosis by using a cocktail of various colour organelle-targeted fluorescent probes2019
- Author(s)
  Hirayama Tasuku、Miki Ayaji、Nagasawa Hideko
- Journal Title
  
  Metallomics
  
  Volume: 11 Issue: 1 Pages: 111-117
- DOI
  10.1039/c8mt00212f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05102, KAKENHI-PROJECT-18H02110, KAKENHI-PROJECT-17K19207
[Journal Article] Effects of 2-(2-Chlorophenyl)ethylbiguanide on ERAD Component Expression in HT-29 Cells Under a Serum- and Glucose-Deprived Condition2019
- Author(s)
  Oh-hashi Kentaro、Matsumoto Shiori、Sakai Takayuki、Hirata Yoko、Okuda Kensuke、Nagasawa Hideko
- Journal Title
  
  Applied Biochemistry and Biotechnology
  
  Volume: － Issue: 4 Pages: 1009-1021
- DOI
  10.1007/s12010-019-02969-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05102, KAKENHI-PROJECT-15K07894, KAKENHI-PROJECT-17K19901
[Journal Article] A mitochondria-targeted fluorescent probe for selective detection of mitochondrial labile Fe(ii)2018
- Author(s)
  Hirayama Tasuku、Kadota Satoki、Niwa Masato、Nagasawa Hideko
- Journal Title
  
  Metallomics
  
  Volume: 10 Issue: 6 Pages: 794-801
- DOI
  10.1039/c8mt00049b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05102, KAKENHI-PROJECT-18H02110
[Journal Article] Abstract 2322: Ferroptosis induced by erastin in RAS mutant ovarian cancer cells2018
- Author(s)
  Takenaka Motoki、Suzuki Noriko、Mori Minako、Aoki Hitomi、Hirayama Tasuku、Nagasawa Hideko、Morishige Ken-ichirou
- Journal Title
  
  Cancer Research
  
  Volume: 78 Issue: 13_Supplement Pages: 2322-2322
- DOI
  10.1158/1538-7445.am2018-2322
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05102
[Journal Article] Fe(II) Ion Release during Endocytotic Uptake of Iron Visualized by a Membrane-Anchoring Fe(II) Fluorescent Probe2018
- Author(s)
  Niwa Masato、Hirayama Tasuku、Oomoto Ikumi、Wang Dan Ohtan、Nagasawa Hideko
- Journal Title
  
  ACS Chemical Biology
  
  Volume: - Issue: 7 Pages: 1853-1861
- DOI
  10.1021/acschembio.7b00939
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05102, KAKENHI-PROJECT-15J11637, KAKENHI-PUBLICLY-18H04740
[Journal Article] Iron regulatory protein 2 in ovarian endometrial cysts2017
- Author(s)
  Takenaka M., Suzuki N., Mori M., Hirayama T., Nagasawa H., and Morishige K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 印刷中 Issue: 4 Pages: 789-794
- DOI
  10.1016/j.bbrc.2017.04.115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05102
[Journal Article] Non-Thermal Plasma Induces a Stress Response in Mesothelioma Cells Resulting in Increased Endocytosis, Lysosome Biogenesis and Autophagy.2017
- Author(s)
  Shi. L., Ito, F., Wang, Y., Okazaki, Y., Tanaka, H., Mizuno, M., Hori. M., Hirayama, T., Nagasawa, H., Richardson, Des R, Toyokuni, S.
- Journal Title
  
  Free Radic. Biol. Med.
  
  Volume: 108 Pages: 904-917
- DOI
  10.1016/j.freeradbiomed.2017.04.368
- NAID
  120006343682
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05102, KAKENHI-PROJECT-15K08398, KAKENHI-PROJECT-16K15257
[Journal Article] Dietary iron restriction alleviates renal tubulointerstitial injury induced by protein overload in mice2017
- Author(s)
  Yasumasa Ikeda, Yuya Horinouchi, Hirofumi Hamano, Tasuku Hirayama, Seiji Kishi, Yuki Izawa-Ishizawa, Masaki Imanishi, Yoshito Zamami, Kenshi Takechi, Licht Miyamoto, Keisuke Ishizawa, Ken-ichi Aihara, Hideko Nagasawa, Koichiro Tsuchiya, and Toshiaki Tamaki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 10621-10621
- DOI
  10.1038/s41598-017-11089-0
- NAID
  120006534998
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08549, KAKENHI-PROJECT-16H05102, KAKENHI-PROJECT-15K01716, KAKENHI-PROJECT-15K07967, KAKENHI-PROJECT-16K16603, KAKENHI-PROJECT-16K18884
[Journal Article] Bismuth-rhodamine: a new red light-excitable photosensitizer2017
- Author(s)
  Tasuku Hirayama, Akari Mukaimine, Kenta Nishigaki, Hitomi Tsuboi, Shusaku Hirosawa, Kensuke Okuda, Masahiro Ebihara, and Hideko Nagasawa
- Journal Title
  
  Dalton Trans.
  
  Volume: 46 Issue: 46 Pages: 15991-15995
- DOI
  10.1039/c7dt03194g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07894, KAKENHI-PROJECT-16H05102
[Journal Article] Role of catalytic iron and oxidative stress in nitrofen-induced congenital diaphragmatic hernia and its amelioration by Saireito (TJ-114)2017
- Author(s)
  Hirako, S., Tsuda, H., Ito, F., Okazaki, Y., Hirayama, T., Nagasawa, H., Nakano, T., Imai, K., Kotani, T,. F., Kikkawa, Toyokuni, S.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 61 Issue: 3 Pages: 176-182
- DOI
  10.3164/jcbn.17-17
- NAID
  130006191919
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05102, KAKENHI-PROJECT-15K08398
[Journal Article] A universal fluorogenic switch for Fe(II) ion based on N-oxide chemistry permits the visualization of intracellular redox equilibrium shift towards labile iron in hypoxic tumor cells2017
- Author(s)
  Hirayama T., Tsuboi H., Niwa M., Miki A., Kadota S., Ikeshita Y., Okuda K., and Nagasawa H.
- Journal Title
  
  Chem Sci
  
  Volume: 印刷中 Issue: 7 Pages: 4858-4866
- DOI
  10.1039/c6sc05457a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05102, KAKENHI-PROJECT-15K07894, KAKENHI-PROJECT-15J11637
[Journal Article] Elucidating the rapid action of 2-(2-chlorophenyl)ethylbiguanide on HT-29 cells under a serum- and glucose-deprived condition.2017
- Author(s)
  154.Oh-Hashi K., Matsumoto S., Sakai T., Nomura Y., Okuda K., Nagasawa H., Hirata Y.
- Journal Title
  
  Cell Biol. Toxicol.
  
  Volume: - Issue: 4 Pages: 1-12
- DOI
  10.1007/s10565-017-9410-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05102, KAKENHI-PROJECT-15K07894
[Journal Article] Chemical tools for detecting Fe ions2017
- Author(s)
  Hirayama T. and Nagasawa H.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 60 Issue: 1 Pages: 39-48
- DOI
  10.3164/jcbn.16-70
- NAID
  130005188906
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05102, KAKENHI-PROJECT-25702050
[Journal Article] Elucidation of a novel phenformin derivative on glucose-deprived stress responses in HT-29 cells2016
- Author(s)
  Oh-Hashi K., Irie N., Sakai T., Okuda K., Nagasawa H., Hirata Y., Kiuchi K.
- Journal Title
  
  Mol Cell Biochem
  
  Volume: 419 Issue: 1-2 Pages: 29-40
- DOI
  10.1007/s11010-016-2747-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05102
[Journal Article] In vivo retinal and choroidal hypoxia imaging using a novel activatable hypoxia-selective near-infrared fluorescent probe2016
- Author(s)
  Fukuda S, Okuda K, Kishino G, Hoshi S, Kawano I, Fukuda M, Yamashita T, Beheregaray S, Nagano M, Ohneda O, Nagasawa H, Oshika T
- Journal Title
  
  Graefes Arch Clin Exp Ophthalmol
  
  Volume: 254 Issue: 12 Pages: 2373-2385
- DOI
  10.1007/s00417-016-3476-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293353, KAKENHI-PROJECT-15K07894
[Journal Article] Solution-Phase Synthesis and Biological Evaluation of Triostin A and its Analogues2016
- Author(s)
  Kozo Hattori, Kota Koike, Kensuke Okuda, Tasuku Hirayama, Masahiro Ebihara, Mei Takenaka, Hideko Nagasawa
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 14 Issue: 6 Pages: 2090-2111
- DOI
  10.1039/c5ob02505b
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670059
[Journal Article] 低酸素をターゲットとした卵巣癌治療薬の展望2015
- Author(s)
  鈴木紀子、永澤秀子、水野智子、森重健一郎
- Journal Title
  
  産科と婦人科
  
  Volume: 82 Pages: 1106-1111
- Data Source
  KAKENHI-PROJECT-25462588
[Journal Article] Catalytic ferrous iron in amniotic fluid as a predictive marker of human maternal-fetal disorders2015
- Author(s)
  Hattori Y, Mukaide T, Jiang L, Kotani T, Tsuda H, Mano Y, Sumigama S, Hirayama T, Nagasawa H, Kikkawa F and Toyokuni S.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 56 Issue: 1 Pages: 57-63
- DOI
  10.3164/jcbn.14-82
- NAID
  130004704977
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24108008, KAKENHI-PROJECT-24390029
[Journal Article] The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe.2015
- Author(s)
  Takata S, Masuda T, Nakamura S, Kuchimaru T, Tsuruma K, Shimazawa M, Nagasawa H, Kizaka-Kondoh S, Hara H.
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 9898-9898
- DOI
  10.1038/srep09898
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25250012, KAKENHI-PROJECT-26670059
[Journal Article] The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stemcells in ovarian cancer2015
- Author(s)
  Nozawa-Suzuki N, Nagasawa H, Ohnishi K, Morishige K-I
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 457 Pages: 706-711
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25462588
[Journal Article] The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stem cells in ovarian cancer2015
- Author(s)
  Noriko Nozawa-Suzukia, Hideko Nagasawab, Ken Ohnishic, Ken-ichirou Morishigea
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 457 Issue: 4 Pages: 706-711
- DOI
  10.1016/j.bbrc.2015.01.053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390029, KAKENHI-PROJECT-26462519, KAKENHI-PROJECT-26670059
[Journal Article] Histological detection of catalytic ferrous iron with the selective turn-on fluorescent probe RhoNox-1 in a Fenton reaction-based rat renal carcinogenesis model.2014
- Author(s)
  Mukaide T, Hatori Y, Misawa N, Funahashi S, Jiang L, Hirayama T, Nagasawa H,Toyokuni S
- Journal Title
  
  Free Radic Res.
  
  Volume: 48 Issue: 9 Pages: 990-5
- DOI
  10.3109/10715762.2014.898844
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24108008, KAKENHI-PROJECT-24390029, KAKENHI-PROJECT-24390094, KAKENHI-PROJECT-25702050, KAKENHI-PROJECT-221S0001
[Journal Article] Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment2014
- Author(s)
  Narise K, Okuda K, Enomoto Y, Hirayama T, Nagasawa H
- Journal Title
  
  Drug Des. Devel. Ther.
  
  Volume: 8 Pages: 701-717
- DOI
  10.2147/dddt.s59679
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390029
[Journal Article] A new class of high-contrast Fe(II) selective fluorescent probes based on spirocyclized scaffolds for visualization of intracellular labile iron delivered by transferrin.2014
- Author(s)
  Niwa, M., Hirayama, T., Okuda, K., Nagasawa, H.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 12 Issue: 34 Pages: 6590-6597
- DOI
  10.1039/c4ob00935e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390029, KAKENHI-PROJECT-25702050
[Journal Article] The novel hypoxic cytotoxin, TX-2098 has antitumor effect in pancreatic cancer ; possible mechanism through inhibiting VEGF and hypoxia inducible factor-1a targeted gene expression2012
- Author(s)
  Kotaro Miyake, Hideko Nagasawa, Mitsuo Shimada
- Journal Title
  
  Exp. Cell. Res
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21390033
[Journal Article] Development of a Hypoxia-Selective Near-Infrared Fluorescent Probe for Non-invasive Tumor Imaging2012
- Author(s)
  Bahaa Gamal Mohamed Youssif, Kensuke Okuda, Hideko Nagasawa
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60 Issue: 3 Pages: 402-407
- DOI
  10.1248/cpb.60.402
- NAID
  130001852429
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390033, KAKENHI-PROJECT-22790042, KAKENHI-PLANNED-22112009
[Journal Article] Evaluating the Usefulness of a Novel 10B-Carrier Conjugated With Cyclic RGD Peptide in Boron Neutron Capture Therapy,S.-I2012
- Author(s)
  Masunaga,S. Kimura,T. Harada,K. Okuda,Y. Sakurai,H. Tanaka,et al
- Journal Title
  
  World J Oncol
  
  Volume: 3(3) Pages: 103-112
- DOI
  10.4021/wjon477w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22680044, KAKENHI-PROJECT-23300348, KAKENHI-PROJECT-24791361
[Journal Article] 2-Nitroimidazole-tricarbocyanine conjugate as a near-infrared fluorescent probe for in vivo imaging of tumor hypoxia2012
- Author(s)
  Kensuke Okuda, Hideko Nagasawa
- Journal Title
  
  Bioconjug. Chem
  
  Volume: 23(3) Pages: 324-329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390033
[Journal Article] Evaluating the usefulness of a novel 10B-carrier conjugated with cyclic RGD peptide in boron neutron capture therapy2012
- Author(s)
  Masunaga S, Kimura S, Harada T, Okuda K, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Maruhashi A, Nagasawa H, Ono K
- Journal Title
  
  World J Oncol
  
  Volume: (掲載確定)(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300348
[Journal Article] Drug discovery for targeting tumor microenvironment.2011
- Author(s)
  Nagasawa H.
- Journal Title
  
  J.Pharm.Sci
  
  Volume: 115 Pages: 446-452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390033
[Journal Article] Pathophysiological Response to Hypoxia - From the Molecular Mechanisms of Malady to Drug Discovery:Drug Discovery for Targeting the Tumor Microenvironment2011
- Author(s)
  Hideko Nagasawa
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 115 Issue: 4 Pages: 446-452
- DOI
  10.1254/jphs.10R25FM
- NAID
  10029893139
- ISSN
  1347-8613, 1347-8648
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390033
[Journal Article] Synthesis and evaluation of cyclic RGD-boron cluster conjugates to develop tumor-selective boron carriers for boron neutron capture therapy2011
- Author(s)
  Kimura S, Masunaga S, Harada T, Kawamura Y, Ueda S, Okuda K, Nagasawa H
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 19(5) Issue: 5 Pages: 1721-1728
- DOI
  10.1016/j.bmc.2011.01.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300348
[Journal Article] Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis2011
- Author(s)
  Hisanori Hattori, Kensuke Okuda, Hideko Nagasawa
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 19(18) Issue: 18 Pages: 5392-5401
- DOI
  10.1016/j.bmc.2011.07.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390033
[Journal Article] An Arylidene-Thiazolidinedione Derivative, GPU-4, without PPARγActivation, Reduces Retinal Neovascularization2011
- Author(s)
  Shinsuke Nakamura, Hideko Nagasawa, Hideaki Hara
- Journal Title
  
  Curr. Neurovasc. Res
  
  Volume: 8(1) Pages: 25-34
- URL
  http://www.benthamdirect.org/pages/b_viewarticle.php?articleID=3165504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390033
[Journal Article] Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II2010
- Author(s)
  Douglas A. Kuntz, Hideko Nagasawa, David R. Rose
- Journal Title
  
  Chem Bio Chem
  
  Volume: 11(5) Issue: 5 Pages: 673-80
- DOI
  10.1002/cbic.200900750
- Data Source
  KAKENHI-PROJECT-21390033
[Journal Article] Design of novel hypoxia-targeting IDO hybrid inhibitors conjugated with an unsubstituted L-TRP as an IDO affinity moiety2010
- Author(s)
  Hitomi Nakashima, Hideko Nagasawa, Hitoshi Hori
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 662 Pages: 415-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390033
[Journal Article] A chemical biosynthesis design for an antiatherosclerosis drug by acyclic tocopherol intermediate analogue based on "isoprenomics"2009
- Author(s)
  Yoshihiro Uto, Hideko Nagasawa, Hitoshi Hori
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 645 Pages: 109-14
- DOI
  10.1007/978-0-387-85998-9_17
- ISBN
  9780387859972, 9780387859989
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390033
[Journal Article] Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer2009
- Author(s)
  Kotaro Miyake, Hideko Nagasawa, Hitoshi Hori
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 64(5) Issue: 5 Pages: 885-92
- DOI
  10.1007/s00280-009-0937-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390033
[Journal Article] Copper-catalyzed synthesis of benzoxazoles via a regioselective C-H functionalization/C-O bond formation under an air atmosphere2009
- Author(s)
  Ueda S., Nagasawa H.
- Journal Title
  
  J. Org. Chem 74
  
  Pages: 4272-4277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590102
[Journal Article] Correlation between antiangiogenic activity and antioxidant activity of various components from propolis2009
- Author(s)
  Mok-Ryeon Ahn, Hideko Nagasawa, Toshiro Ohta
- Journal Title
  
  Mol. Nutr. Food Res
  
  Volume: 53(5) Issue: 5 Pages: 643-51
- DOI
  10.1002/mnfr.200800021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390033
[Journal Article] Facile Synthesis of 1, 2, 4-Triazoles via a Copper-Catalyzed Tandem Addition-Oxidative Cyclization2009
- Author(s)
  Satoshi Ueda, Hideko Nagasawa
- Journal Title
  
  J. Am. Chem
  
  Volume: 131(42) Issue: 42 Pages: 15080-1
- DOI
  10.1021/ja905056z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390033
[Journal Article] Significance of nitroimidazole compounds and hypoxia-induceble factor-1 for imaging tumor hypoxia2009
- Author(s)
  Kizaka-Kondoh S., Nagasawa H.
- Journal Title
  
  Cancer Science, 100 doi : 10.1111/j. 1349-7006. 2009. 01195. x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590102
[Journal Article] Copper-Catalyzed Synthesis of Benzoxazoles via a Regioselective C-H Functionalization/C-O Bond Formation under an Air Atmosphere2009
- Author(s)
  Satoshi Ueda, Hideko Nagasawa
- Journal Title
  
  J. Org. Chem
  
  Volume: 74(11) Issue: 11 Pages: 4272-7
- DOI
  10.1021/jo900513z
- Data Source
  KAKENHI-PROJECT-21390033
[Journal Article] Bretz W. ; Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis2008
- Author(s)
  Paulino N., Abreu S.R., Uto Y., Nagasawa H. Hori H. et.al.
- Journal Title
  
  European Journal of Pharmacology 587
  
  Pages: 296-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590102
[Journal Article] Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2, 3-dioxygenase inhibitors2008
- Author(s)
  Nakashima H., Uto Y., Nakata E., Nagasawa H. Hori H. et.al.
- Journal Title
  
  Bioorganic & Medicinal Chemistry 16
  
  Pages: 8661-8669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590102
[Journal Article] TX-2152 : a conformationally rigid and electron-rich diyne analogue of FTY720 with in vivo antiangiogenic activity2008
- Author(s)
  Nakayama S., Uto Y., Nagasawa H. Hori H. et.al.
- Journal Title
  
  Bioorganic & Medicinal Chemistry 16
  
  Pages: 7705-7714
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590102
[Journal Article] The novel hypoxic cellradiosensitizer, TX-1877 has antitumoractivity through suppression ofangiogenesis and inhibits liver metastasison xenograft model of pancreaticcancer2008
- Author(s)
  Miyake K., Uto Y., Nagasawa H. Hori H. et.al.
- Journal Title
  
  Cancer Letters 272
  
  Pages: 325-335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590102
[Journal Article] Dependency of the effect of a vascular disrupting agent on sensitivity to tirapazamine and gamma-ray inadiation upon the timing of its administration and tumor size,with reference to the effect on intratumor quiescent cells2007
- Author(s)
  Nagasawa Hideko
- Journal Title
  
  Cancer Res.Clin.Oncol. 133
  
  Pages: 47-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591590
[Journal Article] Design,synthesis and radiosensitizing activities of sugar-hybrid hypoxic cell radiosensitizers.2007
- Author(s)
  Nagasawa Hideko
- Journal Title
  
  Bioorganic & Medicinal Chemistry 16
  
  Pages: 675-682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591590
[Journal Article] The uselfulness of mild temperature hyperthemlia combined with continuous tirapazamine administration under reduced dose rate irradiation with gamma-rays2007
- Author(s)
  Nagasawa Hideko
- Journal Title
  
  International Journal of Hyperthermia 23
  
  Pages: 29-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591590
[Journal Article] Suppression of tumor-induced angiogenesis by Brazilian propolis:major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation2007
- Author(s)
  Nagasawa Hideko
- Journal Title
  
  Cancer Letters 252
  
  Pages: 235-243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591590
[Journal Article] Effect of Molecular Chirality and Side Chain Bulkiness on Angiogenesis of Haloacetylcarbamoy1-2-nitroimidazole Compounds.2007
- Author(s)
  Nagasawa Hideko
- Journal Title
  
  Anticancer Res 27
  
  Pages: 3693-3700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591590
[Journal Article] Dependency of the effect of a vascular disrupting agent on sensitivity to tirapazamine and gamma-ray irradiation upon the timing of its administration and tumor size, with reference to the effect on intratumor quiescent cells2007
- Author(s)
  Masunaga S., Nagasawa H. Uto Y., Hori H., Ono K.
- Journal Title
  
  J. Cancer Res. Clin. Oncol 133
  
  Pages: 47-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590102
[Journal Article] Design of hypoxia-targeting drugs as new cancer chemotherapeutics.2006
- Author(s)
  Hideko Nagasawa
- Journal Title
  
  Biological ＆ Pharmaceutical Bulletin 29・12
  
  Pages: 2335-2342
- Data Source
  KAKENHI-PROJECT-16659031
[Journal Article] Gc protein (vitamin D-binding protein) : Gc genotyping and GcMAF precursor activity2005
- Author(s)
  Hideko Nagasawa
- Journal Title
  
  Anticancer Research 25・6A
  
  Pages: 3689-3695
- Data Source
  KAKENHI-PROJECT-16659031
[Journal Article] Association of the Macrophage Activating Factor (MAF) Precursor Activity with Polymorphism in Vitamin D-binding Protein2004
- Author(s)
  Hideko Nagasawa
- Journal Title
  
  Anticancer Research 24・5c
  
  Pages: 3361-3366
- Data Source
  KAKENHI-PROJECT-16659031
[Journal Article] Association of the Macrophage Activating Factor (MAF) Precursor Activity with Polymorphism in Vitamin D-binding Protein.2004
- Author(s)
  Hideko Nagasawa
- Journal Title
  
  Anticancer Research 24
  
  Pages: 3361-3366
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370758
[Journal Article] Association of the Macrophage Activating Factor (MAF) Precursor Activity with Polymorphism in Vitamin D-binding Protein.2004
- Author(s)
  Hideko Nagasawa
- Journal Title
  
  Anticancer Research 24・5c
  
  Pages: 3361-3366
- Data Source
  KAKENHI-PROJECT-14370758
[Journal Article] Association of the Macrophage Activating Factor (MAF) Precursor Activity with Polymorphism in Vitamin D-binding Protein.2004
- Author(s)
  Hideko Nagasawa
- Journal Title
  
  Anticancer Research 24,5c
  
  Pages: 3361-3366
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370758
[Journal Article] Antiangiogenic hypoxic cytotoxin TX-402 inhibits hypoxia-inducible factor 1 signaling pathway.2003
- Author(s)
  Hideko Nagasawa
- Journal Title
  
  Anticancer Research 23,6a
  
  Pages: 4427-4434
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370758
[Journal Article] Antiangiogenic hypoxic cytotoxinTX-402 inhibits hypoxia-inducible factor 1 signaline pathway.2003
- Author(s)
  Hideko Nagasawa
- Journal Title
  
  Anticancer Research 23
  
  Pages: 4427-4434
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370758
[Journal Article] 低酸素性癌細胞を標的とする放射線増感剤/制癌剤の分子設計2002
- Author(s)
  永澤秀子
- Journal Title
  
  放射線生物研究 37
  
  Pages: 359-375
- NAID
  40005643855
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370758
[Patent] 】抗腫瘍効果を有する化合物及びその製造方法2019
- Inventor(s)
  永澤秀子、平山祐、小池晃太
- Industrial Property Rights Holder
  永澤秀子、平山祐、小池晃太
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-222124
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16H05102
[Patent] 低酸素関連眼疾患のインビボ用診断薬及び治療用組成物2014
- Inventor(s)
  福田慎一、大鹿哲郎、永澤秀子、奥田健介
- Industrial Property Rights Holder
  福田慎一、大鹿哲郎、永澤秀子、奥田健介
- Industrial Property Rights Type
  特許
- Filing Date
  2014-09-30
- Data Source
  KAKENHI-PROJECT-24590054
[Patent] 低酸素関連眼疾患のインビボ用診断薬及び治療用組成物2014
- Inventor(s)
  福田　慎一、大鹿　哲郎、永澤　秀子、奥田　健介
- Industrial Property Rights Holder
  福田　慎一、大鹿　哲郎、永澤　秀子、奥田　健介
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-200397
- Filing Date
  2014-09-30
- Data Source
  KAKENHI-PROJECT-24390029
[Patent] 低酸素領域イメージング用近赤外蛍光プローブ2009
- Inventor(s)
  永澤秀子奥田健介
- Industrial Property Rights Holder
  岐阜市
- Industrial Property Number
  2009-050992
- Filing Date
  2009-03-04
- Data Source
  KAKENHI-PROJECT-20011009
[Presentation] ミトコンドリア放出型光ケージドペルオキシド化合物の開発研究2023
- Author(s)
  辻美恵子、平山祐、永澤秀子
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K19383
[Presentation] Equisetin誘導体合成における熱または酵素的Diels-Alder反応によるデカリン形成の立体化学制御2023
- Author(s)
  狩谷拓実、長谷川颯人、辻美恵子、平山祐、加藤直樹、永野真吾、永澤秀子
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PLANNED-19H05778
[Presentation] Development of photocaged peroxides for the control of oxidative stress in mitochondria2023
- Author(s)
  Mieko Tsuji, Haruno Taira, Tasuku Hirayama, Hideko Nagasawa
- Organizer
  Future Drug Discovery Empowered by Chemical Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19383
[Presentation] 腫瘍特異的なアミノ酸輸送系を利用する中性子捕捉療法のための新規ホウ素キャリアの開発2023
- Author(s)
  新津明穂、山本凌大、真田悠生、渡邉翼、増永慎一郎、辻美恵子、平山佑、永澤秀子
- Organizer
  日本薬学会第143年会（札幌）
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] CD44v陽性治療抵抗性子宮頸癌の酸化ストレス耐性の抑制による化学療法増感2022
- Author(s)
  永澤秀子、森美奈子、辻美恵子、平山祐、森重健一郎
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K19383
[Presentation] ヘム選択的蛍光プローブを用いたヘム排出機構およびフェロトーシスにおけるヘム変動の解析2022
- Author(s)
  河合寛太、平山祐、位田雅俊、村上貴規、辻美恵子、永澤秀子
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PLANNED-19H05778
[Presentation] ホウ素中性子捕捉療法のためのLAT-1 輸送基質を模倣したホウ素キャリアの開発2022
- Author(s)
  永澤秀子、新津明穂、真田悠生、辻美恵子、平山祐、増永慎一郎
- Organizer
  第50回放射線による制癌シンポジウム（札幌）
- Invited
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] アミノ酸トランスポーターを標的とする新規ホウ素キャリアの開発2021
- Author(s)
  松下明香里、辻美恵子、真田裕生、平山祐、増永慎一郎、永澤秀子
- Organizer
  京大複合研第55回学術講演会
- Data Source
  KAKENHI-PROJECT-19H03352
[Presentation] 中性子捕捉療法のための10B－ホウ素クラスター含有アミノ酸誘導体の開発2021
- Author(s)
  松下明香里、辻美恵子、平山祐、永澤秀子
- Organizer
  日本薬学会大141年会
- Data Source
  KAKENHI-PROJECT-19H03352
[Presentation] 光刺激細胞内酸化ストレス誘導化合物の開発研究2021
- Author(s)
  辻美恵子、青木達也、平良遥乃、並木進、平山祐、永澤秀子
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PLANNED-19H05778
[Presentation] 細胞膜を標的とした光ケージド過酸化物の開発2021
- Author(s)
  青木達也、辻美恵子、平良遥乃、平山祐、永澤秀子
- Organizer
  日本酸化ストレス学会東海支部第９回学術集会
- Data Source
  KAKENHI-PLANNED-19H05778
[Presentation] 中性子捕捉療法のためのアミノ酸トランスポーターを標的とするホウ素キャリアの開発(Development of boron carrier targeting amino acid transporters for boron neutron capture therapy)2020
- Author(s)
  松下明香里、永澤秀子、平山祐、増永慎一郎
- Organizer
  第79回日本癌学会学術大会（広島）
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] 腫瘍で高発現するトランスポーターを標的とする中性子捕捉療法のためのホウ素キャリアの開発2020
- Author(s)
  松下明香里、辻美恵子、平山祐、永澤秀子
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19H03352
[Presentation] Development of novel bicyclic octadepsipeptids with potent antitumor and antiangiogenic and HIF-1 inhibitory activities2020
- Author(s)
  松下明香里、平山祐、増永慎一郎、永澤秀子
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03352
[Presentation] 細胞内で機能する光解除型TBHPケージド化合物の開発2019
- Author(s)
  〇青木達也、辻美恵子、渡辺航、平良遥乃、平山祐、永澤秀子
- Organizer
  日本酸化ストレス学会東海支部第8回学術集会
- Data Source
  KAKENHI-PLANNED-19H05778
[Presentation] Bismuth-rhodamine誘導体の合成法の確立と光物性制御に関する基礎的研究2019
- Author(s)
  向峯　あかり、平山　祐、辻　美恵子、永澤　秀子
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] Structure-activity relationship study of biguanide derivatives for tumor microenvironment modulator2019
- Author(s)
  Takayuki Sakai, Kentaro Oh-hashi, Yoshiyuki Matsuo, Kiichi. Hirota, Kensuke Okuda, Tasuku Hirayama, Hideko Nagasawa
- Organizer
  第11回日米癌合同会議（11th AACR JCA Joint Conference)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 核局在型二価鉄検出プローブの開発研究2019
- Author(s)
  早舩　花奈、平山　祐、辻　美恵子、永澤　秀子
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] がん微小環境モジュレーターの創出をめざす創薬研究2019
- Author(s)
  永澤秀子、境崇行、小池晃太、奥田健介、平山祐、辻美恵子
- Organizer
  日本薬学会第139年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 細胞内酸化ストレス制御を目指した光解除型ケージドTBHP化合物の開発2019
- Author(s)
  〇辻美恵子、渡辺航、青木達也、平山祐、永澤秀子
- Organizer
  第14回年会日本ケミカルバイオロジー学会
- Data Source
  KAKENHI-PLANNED-19H05778
[Presentation] Structure-activity relationship study of biguanide derivatives for tumor microenvironment modulator2019
- Author(s)
  Takayuki Sakai, Kentaro Oh-hashi, Yoshiyuki Matsuo, Kiichi Hirota, Kensuke Okuda, Tasuku Hirayama, Hideko Nagasawa
- Organizer
  11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research Biology to Precision Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07894
[Presentation] Structure-activity relationship study of quinomycin antibiotics focusing on cross-bridge structures of bicyclic depsipeptides to develop HIF-1 inhibiting antitumor agent2019
- Author(s)
  Hideko Nagasawa, Kota Koike, Masahiro Ebihara, Tasuku Hirayama, Mieko Tsuji
- Organizer
  第11回日米癌合同会議（11th AACR JCA Joint Conference)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 血清およびグルコース欠乏状態での小胞体関連分解因子におけるフェンホルミン誘導体の効果に関する研究2018
- Author(s)
  大橋憲太郎, 松本詩織, 境崇行, 平田洋子, 奥田健介, 永澤秀子
- Organizer
  第24回癌治療増感研究会 in 雲仙
- Data Source
  KAKENHI-PROJECT-15K07894
[Presentation] BNCTのための細胞膜透過性ホウ素クラスターの開発2018
- Author(s)
  永澤秀子
- Organizer
  平成30年度京都大学複合原子力科学研究所専門研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] Hemoglobin-related molecules injure blood-brain barrier via iron accumulation2018
- Author(s)
  Takahiko Imai, Sena Iwata, Tasuku Hirayama, Hideko Nagasawa, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara
- Organizer
  第18回国際薬理学・臨床薬理学会議（WCP2018）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 血清およびグルコース欠乏状態での小胞体関連分解因子におけるフェンホルミン誘導体の効果に関する研究2018
- Author(s)
  大橋憲太郎, 松本詩織, 境崇行, 平田洋子, 奥田健介, 永澤秀子
- Organizer
  第24回癌治療増感研究会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] ホウ素中性子捕捉療法（BNCT）のための細胞膜透過性ホウ素クラスターの開発2018
- Author(s)
  永澤秀子、平山祐、
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 細胞内酸化ストレス制御のための光解除型ケージドTBHP化合物の開発2018
- Author(s)
  辻美恵子、渡辺航、青木達也、平山祐、永澤秀子
- Organizer
  日本酸化ストレス学会東海支部第７回学術集会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] フェノキシルラジカルの反応性に基づく鉄関連タンパク修飾剤の開発2018
- Author(s)
  深谷忠徳、平山祐、永澤秀子
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] エキノマイシンの架橋構造に着目した新規抗腫瘍剤/HIF-1阻害剤の開発2018
- Author(s)
  永澤秀子，小池晃太，海老原昌弘，平山祐，辻美恵子
- Organizer
  第16回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 細胞膜アンカリング型二価鉄イオン蛍光プローブによるトランスフェリン誘導型鉄取り込みのリアルタイム可視化2018
- Author(s)
  丹羽正人、平山祐、大本育美、王丹、永澤秀子
- Organizer
  第12回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] Development And Biological Evaluation Of Echinomycin Analogues For Antitumor Drug2018
- Author(s)
  Kota Koike, Masahiro Ebihara, Tasuku Hirayama, Mieko Tsuji, Hideko Nagasawa
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 遊離ヘムを選択的に検出可能なレシオ型蛍光プローブの開発2018
- Author(s)
  丹羽正人、平山祐、永澤秀子
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 生体内の鉄(II)イオン検出を指向した19F-MRIプローブ分子の開発2018
- Author(s)
  鈴木萌恵、平山祐、柳沢大治郎、遠山育夫、永澤秀子
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 鉄制御分子の創出を目指した二価鉄イオン蛍光プローブによるハイスループットスクリーニング2018
- Author(s)
  廣澤舟作、丹羽正人、平山祐、永澤秀子
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 細胞膜アンカリング型蛍光プローブによるエンドサイトーシス鉄取込過程におけるエンドソーム内二価鉄イオンの検出2018
- Author(s)
  平山祐、丹羽正人、永澤秀子、
- Organizer
  第71回日本酸化ストレス学会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 架橋構造に注目したキノマイシン系抗生物質の構造展開と生物活性評価2018
- Author(s)
  小池晃太，海老原昌弘，平山祐，辻美恵子，永澤秀子
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 二価鉄検出蛍光プローブの多色展開2017
- Author(s)
  ○平山祐、坪井ひとみ、丹羽正人、永澤秀子
- Organizer
  日本酸化ストレス学会東海支部　第5回学術集会
- Place of Presentation
  名古屋
- Year and Date
  2017-02-18
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] Pepducinを基盤とするホウ素捕捉療法のための膜透過性ホウ素キャリアの開発2017
- Author(s)
  磯野蒼、増永慎一郎、平山祐、辻美恵子、永澤秀子
- Organizer
  第35回メディシナルケミストリーシンポジウム(名古屋大)
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] がん微小環境を標的とする創薬研究2017
- Author(s)
  永澤　秀子
- Organizer
  第19回癌治療増感研究シンポジウム
- Place of Presentation
  奈良
- Year and Date
  2017-02-03
- Invited
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 細胞中での拡散性を高めた鉄 (II) イオン蛍光プローブの開発2017
- Author(s)
  ○丹羽正人 , 平山祐 , 奥田健介 , 永澤秀子
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 低グルコース選択毒性を示す新規ビグアニド系抗腫瘍薬のエネルギー代謝に対する作用2017
- Author(s)
  境崇行、辻美恵子、平山祐、奥田健介、永澤秀子
- Organizer
  第１５回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] がん微小環境における低栄養ストレス応答を標的とするビグアニド誘導体の創薬研究2017
- Author(s)
  境崇行, 辻美恵子, 平山祐, 奥田健介, 永澤秀子
- Organizer
  第３５回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 腫瘍のストレス環境適応機構に着目した新たな抗腫瘍薬の創薬スクリーニング2017
- Author(s)
  永澤　秀子
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長﨑
- Year and Date
  2017-03-15
- Invited
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] がん微小環境のエネルギー代謝を標的とするがん治療薬の開発2017
- Author(s)
  境崇行、平山祐、辻美恵子、永澤秀子
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] Design and synthesis of new membrane permeable boron carriers for BNCT based on the pepducin technology2017
- Author(s)
  Aoi Isono, Shinichiro Masunaga, Tasuku Hirayama, Mieko Tsuji, Hideko Nagasawa
- Organizer
  The 9th Young Researchers' BNCT Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] Development of a membrane anchoring Fe(II) fluorescent probe2017
- Author(s)
  Masato Niwa, Tasuku Hirayama, Hideko Nagasawa
- Organizer
  The Second A3 Roundtable Meeting on Chemical Probe
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 酸化ストレス・イメージング～がん細胞のストレス耐性評価に基づく新しい治療法の開発～2017
- Author(s)
  永澤秀子
- Organizer
  第４２９回【医学研究の基礎を語り合う集い】シリーズ・神経機能研究の最前線　No. ５４
- Invited
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] トリオスチンＡの架橋構造に着目した構造展開と生物活性に関する検討2017
- Author(s)
  小池晃太、海老原昌弘、平山祐、辻美恵子、永澤秀子
- Organizer
  第48回中部化学関係学協会支部連合秋季大会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 光線力学療法への応用を目指した新規含ビスマス光増感剤Bi-Rhodamineの開発2017
- Author(s)
  向峯あかり、平山祐、口丸高弘、近藤科江、永澤秀子
- Organizer
  第１５回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] Elucidation of a novel phenformin derivative on the glucose-deprived stress response in HT29 cells.2017
- Author(s)
  Shiori Matsumoto, Takayuki Sakai, Kensuke Okuda, Hideko Nagasawa, Yoko Hirata, Kentaro Oh-hashi
- Organizer
  第４０回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 二価鉄イオン蛍光プローブの構造最適化とハイスループットアッセイへの展開2017
- Author(s)
  平山祐、丹羽正人、廣澤舟作、永澤秀子
- Organizer
  第11回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 生体内硫化水素検出を目指した19F-MRIプローブの開発2017
- Author(s)
  奥田健介、占文虎、平山祐、永澤秀子
- Organizer
  第19回癌治療増感研究シンポジウム
- Place of Presentation
  奈良県文化会館（奈良県・奈良市）
- Year and Date
  2017-02-03
- Data Source
  KAKENHI-PROJECT-15K07894
[Presentation] Pepducinを基盤とするホウ素捕捉療法のための膜透過性ホウ素キャリアの開発2017
- Author(s)
  磯野蒼、増永慎一郎、平山祐、辻美恵子、永澤秀子
- Organizer
  第３５回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] ヒト結腸癌細胞株 HT29 におけるグルコース欠乏性ストレス応答に対する新規フェンホルミン誘導体の効果に関する研究2017
- Author(s)
  松本詩織、入江菜央、境　崇行、奥田健介、永澤秀子、木内一壽、平田洋子、大橋憲太郎
- Organizer
  第８１回日本生化学会中部支部例会、シンポジウム
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] Stractural modification and biological evaluation of quinomycin class cyclic depsipeptides to develop antitumor agents targeting the tumor microenvironment2017
- Author(s)
  Hideko Nagasawa, Kota Koike, Kozo Hattori, Kensuke Okuda, Tasuku Hirayama
- Organizer
  26th French-Japanese Symposium on Medicinal & Fine Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] がん微小環境標的ビグアニド誘導体の創薬研究2017
- Author(s)
  ○境　崇行、平山　祐、奥田　健介、永澤　秀子
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] Design and synthesis of new membrane permeable boron carriers for BNCT based on the pepducin technology.2017
- Author(s)
  Aoi Isono, Shinichiro Masunaga, Tasuku Hirayama, Mieko Tsuji, Hideko Nagasawa.
- Organizer
  9th Young Researchers' BNCT Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] 二価鉄蛍光プローブの開発とがん細胞における鉄動態解析への応用2017
- Author(s)
  平山祐 , 丹羽正人, ○永澤秀子
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Invited
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 細胞質中での拡散性を示す鉄(II)イオン蛍光プローブの開発とその応用2017
- Author(s)
  丹羽正人、平山祐、永澤秀子
- Organizer
  第３５回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] Triostin A の新規類縁体合成と生物活性評価2016
- Author(s)
  ○小池　晃太、服部　幸三、平山　祐、奥田　健介、永澤　秀子
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] Design, synthesis and biological evaluation of Triostin A and its analogues2016
- Author(s)
  ○Kota Koike, Tasuku Hirayama, Kensuke Okuda, Hideko Nagasawa
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] ペプデュシン送達システムを基盤とする膜透過性ホウ素キャリアの開発2016
- Author(s)
  ○永澤　秀子、磯野蒼、平山祐、奥田　健介、増永　慎一郎
- Organizer
  第54回日本放射線腫瘍学会生物部会学術大会
- Place of Presentation
  大阪
- Year and Date
  2016-07-16
- Invited
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] A color series of fluorescent probes for detection of labile iron in living cells2016
- Author(s)
  ○Tasuku Hirayama, Hitomi Tsuboi, Masato Niwa, Hideko Nagasawa
- Organizer
  8th Asian Biological Inorganic Chemistry Conference（AsBIC8）
- Place of Presentation
  オークランド
- Year and Date
  2016-12-04
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] Development of a plasma membrane-anchoring Fe(II) probe based on N-oxide chemistry2016
- Author(s)
  ○Masato Niwa, Tasuku Hirayama, Hideko Nagasawa
- Organizer
  8th Asian Biological Inorganic Chemistry Conference（AsBIC8）
- Place of Presentation
  オークランド
- Year and Date
  2016-12-04
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] ミトコンドリア局在型二価鉄蛍光プローブを使った鉄依存的細胞死の解析2016
- Author(s)
  ○平山祐、奥田健介、永澤秀子
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 二価鉄蛍光プローブによる ferroptosis の鉄動態解析2016
- Author(s)
  ○三木　彩路、平山　祐、永澤　秀子
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2016
- Place of Presentation
  岐阜
- Year and Date
  2016-10-30
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] ホウ素中性子捕捉療法のためのペプデュシンを基盤とする膜透過性ホウ素キャリアの開発2016
- Author(s)
  磯野　蒼、寺嶋　宏朗、平山　祐、奥田　健介、永澤　秀子
- Organizer
  日本薬学会　第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670059
[Presentation] Triostin A の実用的液相合成法の確立及び新規類縁体合成と生物活性評価2016
- Author(s)
  服部　幸三、小池　晃太、奥田　健介、平山　祐、永澤　秀子
- Organizer
  日本薬学会　第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26670059
[Presentation] がん微小環境を標的とする抗腫瘍性抗生物質 Triostin A 及び種々の環状デプシペプチド誘導体の設計・合成および生物活性評価2016
- Author(s)
  奥田健介、服部幸三、小池晃太、平山祐、永澤秀子
- Organizer
  第18回癌治療増感研究シンポジウム
- Place of Presentation
  奈良県文化会館
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PROJECT-26670059
[Presentation] 細胞膜上に局在する鉄(II)イオン検出蛍光プローブの開発2016
- Author(s)
  ○丹羽　正人、平山　祐、奥田　健介、永澤　秀子
- Organizer
  第11回日本ケミカルバイオロジー学会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 新規近赤外蛍光BRETアクセプターの開発2016
- Author(s)
  向峯あかり、奥田健介、平山祐、永澤秀子
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜　（神奈川県・横浜市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K07894
[Presentation] Molecular imaging of iron metabolism during ferroptosis with a novel mitochondria-targeting fluorescent probe2016
- Author(s)
  Tasuku Hirayama, Masato Niwa, Satoki Kadota, Ayaji Miki, Kensuke Okuda, ○Hideko Nagasawa
- Organizer
  2016 World Molecular Imaging Congress
- Place of Presentation
  ニューヨーク
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 細胞小器官選択的蛍光プローブによる鉄依存的細胞死における鉄動態解明2016
- Author(s)
  ○平山祐、三木彩路、丹羽正人、永澤秀子
- Organizer
  第１０回バイオ関連化学シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-16H05102
[Presentation] 環状デプシペプチドtriostin A及びその立体異性体の合成とコンフォメーション解析2015
- Author(s)
  小池晃太、服部幸三、阿部尚仁、奥田健介、平山祐、田中稔幸、大山雅義、永澤秀子
- Organizer
  第61回日本薬学会東海支部総会・大会
- Place of Presentation
  名古屋市立大学
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-26670059
[Presentation] Design and synthesis of new boron carriers based on pepducin chemistry and evaluation of their subcellular distribution2015
- Author(s)
  Aoi Isono, Hiroaki Terashima, Shin-ichiro Masunaga, Tasuku Hirayama, Kensuke Okuda, Hideko Nagasawa
- Organizer
  PACIFICHEM2015
- Place of Presentation
  Hawaii Convention Center
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670059
[Presentation] Design, synthesis, and biological evaluation of cyclic depsipeptides as chemical probes for study of the tumor microenvironment2015
- Author(s)
  Kozo Hattori, Kota Koike, Kensuke Okuda, Tasuku Hirayama, Hideko Nagasawa
- Organizer
  PACIFICHEM2015
- Place of Presentation
  Hawaii Convention Center
- Year and Date
  2015-12-15
- Data Source
  KAKENHI-PROJECT-26670059
[Presentation] Solution-phase Syntheses and Conformational Studies of Antitumor Bicyclic Octadepsipeptides, Triostin A and Its New Diastereomers2015
- Author(s)
  Kozo Hattori, Kota Koike, Naohito Abe, Kensuke Okuda, Tasuku Hirayama, Toshiyuki Tanaka Masayoshi Oyama, Hideko Nagasawa
- Organizer
  ISPSA2015
- Place of Presentation
  徳島文理大学
- Year and Date
  2015-08-30
- Data Source
  KAKENHI-PROJECT-26670059
[Presentation] 近赤外蛍光を有する新規BRETアクセプターの開発2015
- Author(s)
  向峯あかり、奥田健介、平山祐、永澤秀子
- Organizer
  創薬懇話会2015 in 徳島
- Place of Presentation
  グランドエクシブ鳴門　ザ・ロッジ　（徳島県・鳴門市）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-15K07894
[Presentation] DT40細胞のDNA修復欠損細胞パネルを用いた酸素濃度に依存したチラパラザミンのDNA損傷誘発と細胞致死効果の解析2015
- Author(s)
  森脇隆仁，岡本紗季，笹沼博之，永澤秀子，武田俊一，増永慎一郎，田野恵三
- Organizer
  第68回日本酸化ストレス学会学術集会
- Place of Presentation
  鹿児島県民交流センター、（鹿児島県、鹿児島市）
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] Design, synthesis and fluorescence imaging of new membrane permeable boron carrier based on the pepducin chemistry2015
- Author(s)
  Aoi Isono, Hiroaki Terashima, Kensuke Okuda, Tasuku Hirayama, Hideko Nagasawa
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  国立京都国際会館
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670059
[Presentation] 抗腫瘍性抗生物質Triostin A及び種々の環状デプシペプチド誘導体の液相合成2015
- Author(s)
  服部幸三，小池晃太，奥田健介，平山祐，永澤秀子
- Organizer
  第41回反応と合成の進歩シンポジウム
- Place of Presentation
  近畿大学
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-26670059
[Presentation] BRETを介する生物発光イメージングのためのアクセプター近赤外蛍光分子の開発2015
- Author(s)
  向峯あかり、奥田健介、平山祐、永澤秀子
- Organizer
  第６１回　日本薬学会東海支部大会
- Place of Presentation
  名古屋市立大学　（愛知県・名古屋市）
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-15K07894
[Presentation] Characteristics of Differential Cytotoxicity Profile of Tirapazamine between Normoxia and Hypoxia.2015
- Author(s)
  Moriwaki T, Okamoto S, Sasanuma H, Nagasawa H, Takeda S, Masunaga S, Tano K.
- Organizer
  The 15th International Congress of Radiation Research (ICRR)
- Place of Presentation
  国立京都国際会館（京都府、京都市）
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] 腫瘍低酸素イメージングを目指した低酸素応答性化学発光プローブの開発研究2014
- Author(s)
  奥田健介、坂享、平山祐、永澤秀子
- Organizer
  日本薬学会年会第１３４年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590054
[Presentation] 酸化ストレスにおける鉄(II)イオンを検出する蛍光プローブ分子の開発2014
- Author(s)
  平山祐、丹羽正人、門田聡基、今村知子、奥田健介、原英彰、永澤秀子
- Organizer
  第87回日本薬理学会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] 低酸素イメージングを目指す化学発光プローブの開発研究2014
- Author(s)
  奥田　健介、坂享、平山祐、永澤秀子
- Organizer
  第2回低酸素研究会
- Place of Presentation
  早稲田大学先端生命科学センター
- Year and Date
  2014-07-26
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] 卵巣癌細胞スフェロイドモデルにおける低酸素領域の形成とTX-402の効果の検討2014
- Author(s)
  鈴木　紀子、池下　幸恵、形部　智世、大西　健、永澤　秀子、森重　健一郎
- Organizer
  第13回日本婦人科がん分子標的研究会学術集会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] がん微小環境におけるストレス応答を標的とするビグアニド誘導体の構造活性相関2014
- Author(s)
  奥田健介、成瀬康介、境崇行、平山祐、永澤秀子
- Organizer
  第20回癌治療増感研究会
- Place of Presentation
  高知県民文化ホール
- Year and Date
  2014-06-07
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] がん微小環境における低酸素・低栄養ストレス応答を標的とする創薬化学研究2014
- Author(s)
  奥田健介、成瀬康介、境崇行、平山祐、永澤秀子
- Organizer
  第16回癌治療増感研究シンポジウム
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] 低酸素イメージングを目指す化学発光プローブの開発研究2014
- Author(s)
  奥田健介、坂享、平山祐、永澤秀子
- Organizer
  第２回低酸素研究会
- Place of Presentation
  東京
- Year and Date
  2014-07-26
- Data Source
  KAKENHI-PROJECT-24590054
[Presentation] s/nの向上を目指した低酸素応答性近赤外蛍光プローブの開発に関する検討2014
- Author(s)
  西野正人、奥田健介、河野樹、平山祐、永澤秀子
- Organizer
  第６０回日本薬学会東海支部大会
- Place of Presentation
  鈴鹿
- Year and Date
  2014-07-05
- Data Source
  KAKENHI-PROJECT-24590054
[Presentation] s/nの向上を目指した低酸素応答性近赤外蛍光プローブの開発に関する検討2014
- Author(s)
  西野正人、奥田健介、河野樹、平山祐、永澤秀子
- Organizer
  第60回日本薬学会東海支部総会・大会2014
- Place of Presentation
  鈴鹿医療科学大学白子キャンパス
- Year and Date
  2014-07-05
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] 細胞内における鉄(II)イオンを可視化する蛍光プローブ分子の開発2014
- Author(s)
  平山祐・丹羽正人・門田聡基・奥田健介・永澤秀子
- Organizer
  第38回日本鉄バイオサイエンス学会学術集会
- Place of Presentation
  仙台国際センター
- Year and Date
  2014-06-07
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] 卵巣癌細胞スフェロイドモデルにおける低酸素領域の形成とTX-402の効果の検討2013
- Author(s)
  鈴木　紀子、池下　幸恵、形部　智世、大西　健、永澤　秀子、森重　健一郎
- Organizer
  第11回がんとハイポキシア研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] Drug development targeting the adaptive responses of tumor cells to hypoxia and nutrition deprivation in tumor microenvironment2013
- Author(s)
  Narise, K., Okuda, K., Sakai, T., Hirayama, T., Nagasawa, H.,
- Organizer
  9th AFMC International Medicinal Chemistry Symosium
- Place of Presentation
  Taipei
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] 腫瘍低酸素イメージングを目指した低酸応答性化学発光プローブの開発研究2013
- Author(s)
  奥田健介、坂享、平山祐、永澤秀子
- Organizer
  第３１回メディシナルケミストリーシンポジウム
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24590054
[Presentation] がん微小環境における低酸素・低栄養ストレス応答を標的とする創薬化学研究2013
- Author(s)
  成瀬康介、　奥田健介、　永澤秀子
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] 低酸素部位における鉄代謝変動に関する分子イメージング研究2013
- Author(s)
  池下幸恵、形部智世、平山　祐、鈴木紀子、奥田健介、永澤秀子
- Organizer
  第11回がんとハイポキシア研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] 腫瘍低酸素イメージングを目指した低酸素応答性化学発光プローブの開発研究2013
- Author(s)
  坂享、奥田健介、平山祐、永澤秀子
- Organizer
  第４３回複素環化学討論会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24590054
[Presentation] Symthesis and evaluation of cyclic RGD-boron cluster conjugates as a novel ^<10>B-carrier for boron neutron capture therapy2012
- Author(s)
  Nagasawa H, Kimura S, Masunaga S., et al
- Organizer
  At the 15th International Congress on Neutron Capture Therapy
- Place of Presentation
  Tsukuba, Japan
- Data Source
  KAKENHI-PROJECT-23300348
[Presentation] がん微小環境を標的とする創薬研究2012
- Author(s)
  永澤秀子
- Organizer
  第18回国際癌治療増感研究会
- Place of Presentation
  大阪大学銀杏会館(大阪府)
- Year and Date
  2012-06-09
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] 低酸素・低栄養を特徴とするがん微小環境を標的としたブラジル産グリーンプロポリスの創薬化学研究2012
- Author(s)
  永澤秀子
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州市西日本総合展示場(福岡)
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] がん微小環境モジュレータの創製を目指す創薬研究2011
- Author(s)
  永澤秀子
- Organizer
  第9回がんとハイポキシア研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390033
[Presentation] 低酸素がん微小環境を標的とする創薬研究2011
- Author(s)
  永澤秀子
- Organizer
  第15回酸素ダイナミクス研究会
- Place of Presentation
  佐賀
- Data Source
  KAKENHI-PROJECT-21390033
[Presentation] 非侵襲的低酸素イメージングを目指す近赤外蛍光プローブの開発2009
- Author(s)
  永澤秀子
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテルクレメント徳島
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-20011009
[Presentation] 交差共役ケトン骨格を有する抗腫瘍性血管新生阻害剤の構造活性相関2009
- Author(s)
  三原法秀, 林慧, 岡部泰之, 上田聡,奥田健介, 永澤秀子, 宇都義浩, 堀均
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590102
[Presentation] Development of new tumor targeting 10B-carrier : Boron cluster-cyclic RGD pentapeptide conjugates for boron neutron capture therapy2009
- Author(s)
  Kimura S., Inaba Y., Kawamura Y., Masunaga S., Ueda S., Okuda K., Nagasawa H.
- Organizer
  AACR 2009
- Place of Presentation
  Colorado Denver
- Data Source
  KAKENHI-PROJECT-19590102
[Presentation] 低酸素応答を標的としたブラジル産プロポリスの成分探索2009
- Author(s)
  服部久範, 野田美奈絵, 上田聡, 奥田健介, 永澤秀子
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590102
[Presentation] 低酸素イメージングを目指す近赤外蛍光バイオプローブの開発2009
- Author(s)
  岡部泰之, 奥田健介, Bahaa YOUSSIF, 近藤科江, 上田聡, 永澤秀子
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590102
[Presentation] チアゾリジンジオン骨格を有する新規選択的血管新生阻害剤GPU-4の開発2009
- Author(s)
  林慧, 三原法秀, 岡部泰之, 上田聡, 奥田健介, 永澤秀子, 加来田博貴, 松永望, 原英彰
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590102
[Presentation] 低酸素領域を可視化する新規近赤外蛍光プローブの分子設計2009
- Author(s)
  奥田健介, 岡部泰之, 上田聡, 永澤秀子, 近藤科江
- Organizer
  第11回がん治療増感研究シンポジウム
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-19590102
[Presentation] Design, synthesis, and biological evaluation of cyclic imide derivatives as new potent angiogenesis inhibitors2008
- Author(s)
  Nagasawa H., Hayashi K., Okabe Y., Suto T., Mihara N., Ueda S., Kakuta H.
- Organizer
  AACR 2008
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-19590102
[Presentation] 環状イミド構造を有する新規血管新生阻害剤の分子設計2008
- Author(s)
  永澤秀子
- Organizer
  第14回国際癌治療増感研究会
- Place of Presentation
  鈴鹿
- Data Source
  KAKENHI-PROJECT-20011009
[Presentation] チアゾリジンジオン骨格を有する新規選択的血管新生阻害剤の開発2008
- Author(s)
  永澤秀子, 林慧, 三原法秀, 岡部泰之,上田聡, 奥田健介, 加来田博貴, 松永望, 原英彰
- Organizer
  第6回がんとハイポキシア研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-19590102
[Presentation] 環状イミド構造を有する新規血管新生阻害剤の分子設計2008
- Author(s)
  永澤秀子
- Organizer
  第14回国際癌治療増感研究会
- Place of Presentation
  鈴鹿
- Data Source
  KAKENHI-PROJECT-19590102
[Presentation] 細胞膜局在型二価鉄イオン蛍光プローブの開発とその応用
- Author(s)
  丹羽正人、平山祐、奥田健介、永澤秀子
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] Development of a cell-penetrating boron cluster for boron neutron capture therapy
- Author(s)
  Aoi Isono, Kensuke Okuda, Tasuku Hirayama, Hideko Nagasawa
- Organizer
  第73回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26670059
[Presentation] Arylidenethiazolidinedione骨格を基盤とする血管新生阻害剤の開発
- Author(s)
  奥田健介、重面雄紀、竹中芽衣、成瀬康介、平山祐、永澤秀子
- Organizer
  第19回癌治療増感研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] 二価鉄イオン選択的蛍光プローブの開発と低酸素腫瘍細胞における鉄イオンの挙動解明
- Author(s)
  平山祐・形部智世・池下幸恵・奥田健介・永澤秀子
- Organizer
  第12回がんとハイポキシア研究会
- Place of Presentation
  ホテルマリターレ創世佐賀
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] The development study of hypoxia responsive chemiluminescent probe for tumor hypoxia imaging
- Author(s)
  Kensuke Okuda, Toru Ban, Tasuku Hirayama, and Hideko Nagasawa
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-24590054
[Presentation] 低酸素・低栄養ストレス応答を標的とする創薬研究
- Author(s)
  成瀬康介、奥田健介、竹中芽衣、永澤秀子
- Organizer
  第1回低酸素研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] HIF-1/UPR阻害作用および血管新生阻害作用を有する新規がん微小環境モジュレーターGPU-539の開発
- Author(s)
  境　　崇行・成瀬　康介・奥田　健介・永澤　秀子
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台市情報・産業プラザ
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] 生体還元により活性化されるFRET蛍光プローブの開発とPepducin膜透過機構のライブセルイメージング解析
- Author(s)
  辻美恵子、磯野蒼、平山祐、奥田健介、永澤秀子
- Organizer
  第8回日本分子イメージング学会学術大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] Development of direct Intra-cellular drug delivery system based on lipidated peptides, pepducins
- Author(s)
  Nagasawa H.
- Organizer
  第5回日台三者BNCT学術交流会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] 新規PARP 阻害剤の開発を目指すTruce-Smiles転位反応を利用したヘテロ五員環縮合[2,3-c]isoquinoline類の合成
- Author(s)
  奥田健介、豊福優太、平山祐、永澤秀子
- Organizer
  第17回癌治療増感研究シンポジウム
- Place of Presentation
  奈良県文化会館小ホール
- Year and Date
  2015-02-06 – 2015-02-07
- Data Source
  KAKENHI-PROJECT-24390029
[Presentation] ビグアニド系がん微小環境モジュレーターの標的分子解明を目指すアフィニティプローブの開発
- Author(s)
  境　崇行、奥田　健介、竹本　安那、平山　祐、永澤　秀子
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24390029

1. HORI Hitoshi (90119008)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. MASUNAGA Shin-ichiro (80238914)

# of Collaborated Projects: 6 results

# of Collaborated Products: 13 results
3. OKUDA Kensuke (00311796)

# of Collaborated Projects: 5 results

# of Collaborated Products: 34 results
4. HIRAYAMA Tasuku (10600207)

# of Collaborated Projects: 5 results

# of Collaborated Products: 74 results
5. UTO Yoshihiro (20304553)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. 辻美恵子 (40709721)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
7. INAYAMA Seiichi (30051030)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. UEDA Satoshi (50453056)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
9. TANO Keizo (00183468)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
10. MIYAKE Kentaro (20403727)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. MORISHIGE Kenichiro (90283788)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
12. NISHIOKA Masanori (50398020)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 伊東久夫 (20095574)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 柴田徹一 (70051513)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 真田悠生 (50738656)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
16. HARA Hideaki (20381717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. KONDO Shinae (40314182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. SUZUKI NORIKO (40642096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. MIZUNO TOMOKO (60444262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. SOMA Genichiro (00158990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. OHKURA Tamiko (20051740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KAWAMATA Takeshi (80051530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. TAKAGI akira (00758980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 竹内勤 (00051847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 野崎智義 (60198588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 小林正規 (70112688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 島田光生 (10216070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 光藤健司 (70303641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 清中茂樹 (90422980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 古田寿昭 (90231571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. TAKEDA Shun-ichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
32. IKEDA Yasumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. SHI Lei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. INDEN Masatoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. TANAKA Hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 廣田喜一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 松尾禎之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 石澤有紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 今西正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 豊國伸哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 近藤玄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 保住功

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 大鹿哲郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGASAWA Hideko 永澤 秀子

永沢 秀子 ナガサワ ヒデコ

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Therapeutic Strategies Targeting Iron Addiction for KRAS Mutation Refractory CancerPrincipal Investigator

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Drug Discovery Targeting Mitochondrial Iron Sulfur Protein MiNT, a Novel Molecular Target for Anti-Mitochondrial TherapyPrincipal Investigator

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Development of novel boron carrier utilizing amino acid transporters specific for glutamine addiction of cancer cellsPrincipal Investigator

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Development of tumor-selective drug based on synthetic lethal strategy by overcoming oxidative stress tolerance of cancerPrincipal Investigator

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Development of chemical drug delivery system using pepducin for boron carriers of BNCTPrincipal Investigator

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The study of drug development targeting the stress response in the tumor microenvironment for the treatment of refractory cancerPrincipal Investigator

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Molecular design and chemical genetic approach of bio-probe for anti-angiogenic therapyPrincipal Investigator

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NAGASAWA Hideko 永澤秀子

永沢秀子ナガサワヒデコ