SUGIYAMA Yasuyuki 杉山保幸

Researcher Number	90211309
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2005: Gifu University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 2004: 岐阜大学, 大学院・医学研究科, 助教授 2003: 岐阜大学, 医学部, 助教授 2003: 岐阜大学, 医学部附属病院, 助教授 2002: 岐阜大学, 医学部附属病院, 講師 … More 2000 – 2001: 岐阜大学, 医学部・附属病院, 講師 1993 – 1999: 岐阜大学, 医学部, 助手 1991: Gifu University School of Medicine, Second Dpt. of Surgery Research Assistant, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Digestive surgery / General surgery Except Principal Investigator General surgery / Digestive surgery
Keywords	Principal Investigator 消化器癌 / 癌免疫療法 / 樹状細胞 / Activated lymphocyte transfusion / Cancer immunotherapy / Gastroenterological cancer / Antigen presentation / Dendritic cell / 活性化リンパ球移入療法 / 抗原呈示機能 / 抗原提示機能 … More Except Principal Investigator … More Aurora-C (HsAIRK3) / Aurora-A (HsAIRK1) / Colorectal Adenoma / Colorectal Cancer / PLK1 / Centrosome Kinase / assay system / CEA / 好中球 / Colorectal cancer / Centrosomal kinase / Aurora-B(HsAIRK2) / Centrosomal Kinase / Nek2 / SAK / PLK3 / PLK2 / Aurora-C / Aurora-A / Aurora-C(HsAIRK3) / Aurora-A(HsAIRK1) / TNF-α / IL-10 / IL-8 / interleukin-6 / CLP / RP3 / neuropenia / 高度侵襲 / ラット敗血症モデル / SIRS / ラット敗血病モデル / 抗好中球抗体 / サイトカイン / phosphatidylinositol phospholipase C / gastric cancer / irrigation cytology / peritoneal dissemination / PIPLC / 診断 / PIPCL / PI-PLC / 胃癌 / 腹腔洗浄細胞診 / 腹膜播種 / signal transduction / hepatocyte growth factor / serum obtained from 70% hepatecomized rats / hepatocyte proliferating factor / serum senstized with freezing-thawing hepatic tissue / 初代培養肝細胞 / Ca oscillation / 脾内移植肝細胞 / ラット肝凍結融解処理感作血清 / 大網内再移植 / 脾内移植 / 血漿包理法 / 細胞内シグナル伝達 / HGF様因子 / 細胞内情報伝達機構 / 肝細胞増殖因子 / 70%肝切除血清 / 肝細胞増殖促進因子 / 凍結融解処理肝組織感作血清 / Peritoneal carcinomatosis / Immunotherapy / Chemiluminescence / Cytostatic activity / Antitumor effects / Neutrophils / Ok-432 / G csp / KW2228 / G-CSF / 細胞障害活性(cytostatic活性) / 抗腫瘍作用 / 好中球貧食能(CL活性) / 腹腔内遊出好中球(PEN) / OK-432刺激好中球 / OKー432とGーCSF併用投与 / 好中球貧食能 / 好中球の抗腫瘍活性 / 腹腔内遊出細胞(PEC) / 好中球数増殖法 / 担癌生体 / Winn中和試験 / Chemiluminescence活性 / 抗腫瘍活性 / GーCSF / OKー432 / 癌性腹膜炎 / p53遺伝子 / 抗癌剤感受性試験 / apoptosis Less

新しく開発したコラーゲンゲル法を用いたアポトーシスによる抗癌剤感受性試験の試み
- Principal Investigator
  
  川口順敬
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Gifu University
Augmentation of the ability of antigen presentation by peripheral blood dendritic cells derived from gastroenterological cancer patientsPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yasuyuki
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Gifu University
Analysis of expression for HsAIRK and PLK family genes, that regulate chromosome segregation in mitosis, in tumors
- Principal Investigator
  
  OSADA Shinji
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Gifu University
担癌生体末梢血中の樹状細胞の抗原提示機能の評価方法の開発Principal Investigator
- Principal Investigator
  
  杉山保幸
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Gifu University
Studies of neutrophil depleting therapy against overproduction of cytokines in sepsis or end stage of cancer using monoclonal anti neutrophil antibody (RP3)
- Principal Investigator
  
  UMEMOTO Takao
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  GIFU UNIVERSITY SCHOOL OF MEDICINE
Production of new method on peritoncal-irrigation cytology by use of releasing method of carcinoembryonic antigen by phosphatidylinositol phospholipase C
- Principal Investigator
  
  KUNIEDA Katsuyuki
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Gifu University School of Medicine
The hepatocyte proliferating activity of the serum sensitized with freezing-thawing hepatic tissue was examined by mean of intrasplenic transplantation with hepatocytes and characterization of sensitized serum was investigated in terms of the function as hepatocyte growth factor.
- Principal Investigator
  
  KATO Motohisa
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Gifu University
Studies on potentiative effects of antitumor activity by OK-432 activated Neutrophils in combination with CSF
- Principal Investigator
  
  SAJI Shigetoyo
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Gifu University School of Medicine

All 2006 2005 2004 2003 2002

All Journal Article Book

[Book] これだけは知っておきたい癌の免疫化学療法2005
- Author(s)
  杉山保幸
- Publisher
  医薬ジャーナル社(大阪)
- Data Source
  KAKENHI-PROJECT-14370382
[Journal Article] 切除不能進行消化器癌に対する凍結治療の有用性2006
- Author(s)
  杉山保幸, 長田真二他
- Journal Title
  
  消化器科 42・2
  
  Pages: 178-185
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370382
[Journal Article] Therapeutic effect of cryoablation against advanced digestive cancer2006
- Author(s)
  Yasuyuki Sugiyama, Shinji Osada, Kazuya Yamaguchi, Narutoshi Nagao, Takao Takahashi, Kouji Matsui, Chihiro Tanaka, Fumio Sakashita, Naoki Okumura, Yasuharu Tokuyama
- Journal Title
  
  Gastroenterology 42(2)
  
  Pages: 178-185
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370382
[Journal Article] Current status and feasibility of immunotherapy against malignant disease2004
- Author(s)
  Yasuyuki Sugiyama
- Journal Title
  
  The Journal of Therapy 86(7)
  
  Pages: 2201-2205
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370382
[Journal Article] Expression of p53 protein as a predictor of the response to 5-fluorouracil and cisplatin chemotherapy in human gastrointestinal cancer cell lines evaluated with apoptosis by use of thin layer collagen gel2004
- Author(s)
  Matsuhashi N, Saio M, Matsuo A, Sugiyama Y, et al.
- Journal Title
  
  Int J Oncol 24
  
  Pages: 807-813
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370382
[Journal Article] 低用量化学療法による免疫賦活2004
- Author(s)
  杉山保幸, 松橋延壽他
- Journal Title
  
  G.I.Research 12・5
  
  Pages: 408-413
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370382
[Journal Article] 癌免疫療法の現状と展望2004
- Author(s)
  杉山保幸
- Journal Title
  
  治療 86・7
  
  Pages: 2201-2205
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370382
[Journal Article] 低用量化学療法による免疫賦活2004
- Author(s)
  杉山保幸, 長尾成敏, 他9名
- Journal Title
  
  G.I.Research 12・5
  
  Pages: 408-413
- Data Source
  KAKENHI-PROJECT-14370382
[Journal Article] Expression of p53 protein as a predictor of the response to 5-fluorouracil and cisplatin chemotherapy in human gastrointestinal cancer cell lines evaluated with apoptosis by use of thin layer collagen gel.2004
- Author(s)
  Matsuhashi N, Saio M, Matsuo A, Sugiyama Y, Saji S
- Journal Title
  
  Int J Oncol 24
  
  Pages: 807-813
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370382
[Journal Article] Immunopotentiation by low-dose chemotherapy2004
- Author(s)
  Yasuyuki Sugiyama, Nobuhisa Matsuhashi, Kouji Matsui, Takami Fukui, Syhuntaro Honda, Shigeru Mori, Narutoshi Nagao, Kazuya Yamaguchi, Shinji Osada, Kazuhiro Ishihara, Yoshihiro Kawaguchi
- Journal Title
  
  G.I.Research 12(5)
  
  Pages: 408-413
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370382
[Journal Article] Study on the Relationship between Positive Aurora Family Expression and Clinico-pathological of Patients with Colorectal Cancer2003
- Author(s)
  Nagata T, Takahashi T, Sugiyama Y, Saji S
- Journal Title
  
  Journal of Japanese College of Surgeons 28(1)
  
  Pages: 51-58
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571188
[Journal Article] ヒト大腸癌における細胞周期関連遺伝子Polo-like kinase(Plk)1およびPlk3の発見に関する検討2003
- Author(s)
  加藤浩樹, 高橋孝夫, 杉山保幸, 國枝克行, 佐治重豊
- Journal Title
  
  日本外科系連合学会誌 28
  
  Pages: 59-67
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571188
[Journal Article] Mitotic Kinases, Polo-like Kinase (Plk)1 and Plk3 the expressions in human colorectal cancers2003
- Author(s)
  Kato H, Takahashi T, Sugiyama Y, Kunieda K, Saji S
- Journal Title
  
  Journal of Japanese College of Surgeons 28(1)
  
  Pages: 59-67
- NAID
  10010511103
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571188
[Journal Article] Polo-like kinase 1 (PLK1) is overexpressed in primary colorectl cancers.2003
- Author(s)
  Takahashi T, Sano B, Nagata T, Kato H, Sugiyama Y, Kunieda K, Kimura M, Okano Y, Saji S
- Journal Title
  
  Cancer Sci 94(2)
  
  Pages: 148-152
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571188
[Journal Article] 大腸癌における細胞周期関連遺伝子Aurora Familyの発見および臨床病理学的因子に関する検討2003
- Author(s)
  永田高康, 高橋孝夫, 杉山保幸, 佐治重豊
- Journal Title
  
  日本外科系連合学会誌 28
  
  Pages: 51-58
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571188
[Journal Article] 腫瘍抗原処理法別にみた樹状細胞のパルス法と細胞傷害活性増強効果について2003
- Author(s)
  本多俊太郎, 長尾成敏, 杉山保幸他
- Journal Title
  
  日本外科系連合学会誌 28・1
  
  Pages: 29-36
- NAID
  10010511015
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370382
[Journal Article] Polo-like kinase 1(PLK1) is overexpressed in primary colorectl cancers.2003
- Author(s)
  Takahashi T, Sano B, Nagata T, Kato H, Sugiyama Y, Kunieda K, Kimura M, Okano Y, Saji S
- Journal Title
  
  Cancer Sci. 94
  
  Pages: 148-152
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571188
[Journal Article] Augmentative effects on cytotoxic activity of human dendritic cells pulsed with variously treated tumor antigen2003
- Author(s)
  Shuntaro Honda, Narutoshi Nagao, Yasuyuki Sugiyama, Shigetoyo Saji
- Journal Title
  
  J Japanese College of Surgeons 28(1)
  
  Pages: 29-36
- NAID
  10010511015
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370382
[Journal Article] Significance of mixed dendritic cell and tumor cell culture using GM-CSF and TNF-a for augmentation for activated killer cells for adoptive immunotherapy.2002
- Author(s)
  Nagao N., Sugiyama Y., Kato M., Honda S., Yamamoto M., Osada S., Saji S.
- Journal Title
  
  Biotherapy 16(6)
  
  Pages: 612-622
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370382
[Journal Article] Significance of mixed dendritic cell and tumor cell culture using GM-CSF and TNF-a for augmentation for activated killer cells for adoptive immunotherapy2002
- Author(s)
  Nagao N., Sugiyama Y, et al.
- Journal Title
  
  Biotherapy 16・6
  
  Pages: 612-622
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370382

1. SAJI Shigetoyo (80021400)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. UMEMOTO Takao (40223614)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. NAGAO Narutoshi (80334944)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. 川口順敬 (50252135)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MIYA Kiichi (10190729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. AZUMA Shuuji (90167908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KATO Motohisa (20224545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKAO Hiroshi (50144035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KUNIEDA Katsuyuki (60186418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KAWAI Masahiko (80283307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TAKAHASHI Takao (90332684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. OSADA Shinji (80332683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 種村広巳 (60092946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 吉田明彦 (90210674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 辻恭嗣 (20262769)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SUGIYAMA Yasuyuki 杉山 保幸

Research Projects

Research Products

Co-Researchers

新しく開発したコラーゲンゲル法を用いたアポトーシスによる抗癌剤感受性試験の試み

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Augmentation of the ability of antigen presentation by peripheral blood dendritic cells derived from gastroenterological cancer patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of expression for HsAIRK and PLK family genes, that regulate chromosome segregation in mitosis, in tumors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

担癌生体末梢血中の樹状細胞の抗原提示機能の評価方法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies of neutrophil depleting therapy against overproduction of cytokines in sepsis or end stage of cancer using monoclonal anti neutrophil antibody (RP3)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Production of new method on peritoncal-irrigation cytology by use of releasing method of carcinoembryonic antigen by phosphatidylinositol phospholipase C

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The hepatocyte proliferating activity of the serum sensitized with freezing-thawing hepatic tissue was examined by mean of intrasplenic transplantation with hepatocytes and characterization of sensitized serum was investigated in terms of the function as hepatocyte growth factor.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on potentiative effects of antitumor activity by OK-432 activated Neutrophils in combination with CSF

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] これだけは知っておきたい癌の免疫化学療法2005

Author(s)

Publisher

Data Source

[Journal Article] 切除不能進行消化器癌に対する凍結治療の有用性2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Therapeutic effect of cryoablation against advanced digestive cancer2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Current status and feasibility of immunotherapy against malignant disease2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Expression of p53 protein as a predictor of the response to 5-fluorouracil and cisplatin chemotherapy in human gastrointestinal cancer cell lines evaluated with apoptosis by use of thin layer collagen gel2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] 低用量化学療法による免疫賦活2004

Author(s)

Journal Title

Description

SUGIYAMA Yasuyuki 杉山保幸