Murayama Norie 村山典惠

… Alternative Names

MURAYAMA Norie 村山典惠

村山典恵ムラヤマノリエ

村山典惠ムラヤマノリエ

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Researcher Number	90219949
External Links
Affiliation (Current)	2025: 昭和薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2010 – 2024: 昭和薬科大学, 薬学部, 講師 2007 – 2009: Showa Pharmaceutical University, Depf of Pharmacy, Assistant Professor 2006 – 2007: 昭和薬科大学, 薬学部, 助手 2006: Showa Pharmaceutical University, Assistant 2003 – 2005: 上智大学, 理工学部, 助手 … More 1997 – 1998: 慶應義塾大学, 医学部, 助手 1995: 慶應義塾大学, 医学部, 助手 1990 – 1992: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / 応用薬理学・医療系薬学 / Basic Section 47060:Clinical pharmacy-related / Anesthesiology/Resuscitation studies Except Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / 応用薬理学・医療系薬学 / Environmental pharmacy / General pharmacology / Neurochemistry/Neuropharmacology / General pharmacology
Keywords	Principal Investigator P450 / チトクロムP450 / BeWo細胞 / 肝細胞 / 薬物代謝酵素 / 酵素誘導 / HepaRG / 遺伝子多型 / CYP3A / 毒性評価 … More / 連結型培養手法 / 胎盤 / 共存培養 / 胎盤細胞 / 膜透過 / レナリドマイド / 胎盤透過性 / ヒト幹細胞 / 薬学 / 培地組成 / 培養時間 / iPS / 薬物透過性 / ips細胞 / ヒト肝由来HepaＲG cells / 初代培養肝細胞 / 3次元培養法 / iPS細胞 / 培養肝細胞 / 長期間維持培地 / サイトカイン / P4502D6 / HPLC / アルツハイマー治療薬 / 抗うつ薬 / アレル頻度 / P4503A422 / 抗精神薬 / CYP2D6 / CYP3A5 / 相互作用 / 向精神薬 / ミダゾラム水酸化活性 / 促進定数 / GSH / CYP3A4 / ヒト型モデルマウス / 協同性 / サリドマイド / 薬物相互作用 / CYP2B66 / 覚醒遅延 / CYP2B6 / プロポフォール / 麻酔学 / thyroid hormone / CAT assay / phenobarbital / 肝薬物代謝酵素 / 甲状腺ホルモン / DHEA / CAT / フェノバルビタール / CYP2B1 / hepatocyte / 胆汁酸 / BrMB / リトコール酸6β位水酸化 … More Except Principal Investigator フラビン含有酸素添加酵素 / サリドマイド / FMO / P450 / 代謝的活性化 / 薬物代謝酵素 / 酵素誘導 / 薬物代謝 / 不活性化 / アンペロメトリー / PKC / 開口分泌 / Cytochrome P-450 / チトクロームP-450 / 胎盤 / 遺伝子多型 / 薬物相互作用 / FMO3 / 甲状腺ホルモン / チトクロームP450 / パロキセチン / アトモキセチン / P450 2D6 / 相互作用予測 / S-ワルファリン / クマリン / アザムリン / チエニリン酸 / フラフィリン / ヒト肝細胞移植マウス / ポマリドミド / レナリドミド / 肝 / 生理学的薬物動態 / フタル酸エステル / レナリドマイド / ポマリドマイド / サル / CYP3A / Pronofol / Voriconazole / Thalidomide / Metabolic activation / CYP2B6 / Toxicity / 奇形 / 胎仔全培養 / ヒト型モデル動物 / CYP3A7 / ヒト型モデル / Tgマウス / CYP3A5 / 胎児毒性 / amperometric detection / dopamine release / neuron / exocytosis / 単一細胞 / ドパミンニューロン / アンペロメトリィー / ドパミン分泌 / ニューロン / Mvosin-V / Spatio-temporal regulation / Vesicle recruitment / Vesicle movement / Mvosin-ATPase / Exocvtosis / Chromaffin cell / SNARE複合体 / 開口キネティクス / ミオシン-V / 時空的調節 / 顆粒供給 / 顆粒運動 / ミオシン-ATPアーゼ / クロマフィン細胞 / P-450 mixture / Human drug metabolism / Gene expression / チトクロムP-450 / ヒト薬物代謝能 / 異所的発現 / チトクロームb_5 / 酵母内遺伝子発現 / ヒト肝 / Dexamethasone / HNF-4 / GRE / Growth hormone / Thyroid hormone / Hepatocyte / Phenobarbital / 初代培養肝細胞 / 単離肝細胞 / チトクロ-ムPー450 / トリヨードチロニン / フェノバルビタール誘導 / 肝核因子-4 / 遺伝子発現 / グルココルチコイド反応性エレメント / 成長ホルモン / フェノバルビタール / CYP3A4 / ヒト肝移植マウス / P450 3A / フラビン含有酸素添酵素 / 相互作用 / フラビン含有酸素添加酵素3 / グルタチオン付加体 / 反応性代謝物 / ヒト肝移植キメラマウス / ヒト型薬物代謝 / P450 3A4 / 体臭 / トリメチルアミン / 個人差 / 遺伝子活性化 Less

Functional analysis of flavin-containing monooxygenases using species differences and human polymorphisms in primary structures
- Principal Investigator
  
  清水万紀子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
遺伝的多型の定量的予測のための酵素不活化ヒト肝細胞移植マウスと動態モデリング開発
- Principal Investigator
  
  山崎浩史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
Prediction system of risk assessments by change the drug metabolism activity in placenta for pregnancyPrincipal Investigator
- Principal Investigator
  
  Murayama Norie
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
Roles of human cytochrome P450 1A2, 2C9, and 3A4/5 enzymes in drug oxidations mediated by metabolically inactivated human hepatocytes in previously transplanted chimeric mice
- Principal Investigator
  
  Yamazaki Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
Evaluation for pharmacokinetics of chemicals mediated by flavin-containing monooxygenases using humanized animal models
- Principal Investigator
  
  Shimizu Makiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
Relevance to bioactivation and toxicity of thalidomide, pomalidomide, and lenalidomide by human cytochrome P450 3A enzymes in cultured placental cells and humanized-liver mice
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Prediction system of risk assessments by change the drug metabolism activity in placenta for pregnancyPrincipal Investigator
- Principal Investigator
  
  MURAYAMA Norie
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Pharmacokinetics prediction of drugs in humans associated with flavin-containing monooxygenase dependent-oxygenations in livers and kidneys of animal models
- Principal Investigator
  
  SHIMIZU Makiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Evaluaion of Human Cytochrome P450 3A Enzymes in Hepatic and Placental Cells by Thalidomide and Relevance to Bioactivation
- Principal Investigator
  
  Yamazaki Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Drug oxygenations and interactions mediated by polymorphic flavin-containing monooxygenases
- Principal Investigator
  
  SHIMIZU Makiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
The most suitable administration of antidepressive drug to avoid risk of side effects in patientPrincipal Investigator
- Principal Investigator
  
  MURAYAMA Norie
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Thalidomide increases cytochrome P450 activity and drug metabolism in liver through direct activation of nuclear receptor CAR and PXR
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Drug interaction of thalidomide with midazolam and other compounds : heterotropic cooperativiy of human cyochrome P450Principal Investigator
- Principal Investigator
  
  MURAYAMA Norie
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Polymorphic drug-metabolizing enzymes of anesthetics agent propofol rekated to its infusion syndrome.Principal Investigator
- Principal Investigator
  
  MURAYAMA Norie
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Showa Pharmaceutical University
薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらす薬物相互作用と疾病の個人差
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Molecular mechanism of chemical-induced toxicity in fetal livers
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Showa Pharmaceutical University
Molecular mechanisms of exocytotic events in single ventral midbrain dopaminergic neurons : amprometric detection and characterization
- Principal Investigator
  
  SASAKAWA Nobuyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Sophia University
Molecular Mechanisms of Exocytotic Prpces and Its Spatio-temporal Regulation
- Principal Investigator
  
  KUMAKURA Konosuke
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Sophia University
フェノバルビタールによる肝薬物代謝酵素遺伝子の転写活性化機構の解明Principal Investigator
- Principal Investigator
  
  村山典恵
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Keio University
胆汁酸の代謝を行う新規P450分子種の解明Principal Investigator
- Principal Investigator
  
  村山典惠
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Keio University
甲状腺ホルモンによる肝P-450遺伝子の発現機構
- Principal Investigator
  
  YAMAZOE Yasushi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Keio University
Assessment of human drug metabolism by expression of cytochrome P-450 in yeasts.
- Principal Investigator
  
  KATO Ryuichi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Keio University
Regulation of expression of cytochrome P-450 by hormonal factor in primary cultured rat hepatocytes.
- Principal Investigator
  
  KATO Ryuichi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  Keio University

[Book] OECD Environment, Health and Safety Publications Series on Testing and Assessment no. 3312021
- Author(s)
  Ryohji Takano, Norie Murayama, Kana Horiuchi, Masato Kitajima, Masatoshi Kumamoto, Fumiaki Shono, Hiroshi Yamazaki
- Total Pages
  101
- Publisher
  OECD
- Data Source
  KAKENHI-PROJECT-20K07164
[Book] 臨床薬理研究進行財団2007
- Author(s)
  山崎浩史, 清水万紀子, 永島里美, 村山典恵
- Publisher
  薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらすアミン化合物酸化的代謝の個人差に関する臨床薬理学研究「臨床薬理の進歩No.29」
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Book] 臨床薬理研究進行財団(印刷中)2007
- Author(s)
  山崎浩史, 清水万紀子, 永島里美, 村山典恵
- Publisher
  薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらすアミン化合物酸化的代謝の個人差に関する臨床薬理学研究「臨床薬理の進歩No.29」
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4?16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database2023
- Author(s)
  Adachi Koichiro、Ohyama Katsuhiro、Tanaka Yoichi、Sato Tasuku、Murayama Norie、Shimizu Makiko、Saito Yoshiro、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 49 Pages: 100486-100486
- DOI
  10.1016/j.dmpk.2022.100486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07164
[Journal Article] Plasma concentration profiles for hepatotoxic pyrrolizidine alkaloid senkirkine in humans extrapolated from rat data sets using a simplified physiologically based pharmacokinetic model.2022
- Author(s)
  Kamiya, Y., Miura, T., Kato, A., Murayama, N., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Drug Metab Bioanal Lett
  
  Volume: 15 Issue: 1 Pages: 64-69
- DOI
  10.2174/1872312801666211220110055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07139
[Journal Article] Application of CYP1A2-Template System to Understand Metabolic Processes in the Safety Assessment2022
- Author(s)
  Norie Murayama,Takashi Yamada,Yasushi Yamazoe
- Journal Title
  
  Food Safety
  
  Volume: 10 Issue: 4 Pages: 129-139
- DOI
  10.14252/foodsafetyfscj.D-22-00008
- ISSN
  2187-8404
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07139
[Journal Article] Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies2022
- Author(s)
  Daisuke Ogiya, Norie Murayama, Yusuke Kamiya, Rie Saito, Sawako Shiraiwa, Rikio Suzuki, Shinichiro Machida, Kei Tazume, Kiyoshi Ando, Hiroshi Yamazaki
- Journal Title
  
  Annals of Hematology
  
  Volume: 101 Issue: 9 Pages: 2013-2019
- DOI
  10.1007/s00277-022-04893-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17387, KAKENHI-PROJECT-20K07139
[Journal Article] Cytochrome P450 2J Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes2022
- Author(s)
  Uno Yasuhiro、Murayama Norie、Ijiri Moe、Kawaguchi Hiroaki、Yamato Osamu、Shiraishi Mitsuya、Asano Atsushi、Teraoka Hiroki、Mizukawa Hazuki、Nakayama Shouta M.M.、Ikenaka Yoshinori、Ishizuka Mayumi、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 50 Issue: 11 Pages: 1434-1441
- DOI
  10.1124/dmd.122.000930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20K07139
[Journal Article] Combined Risk Assessment of Food-derived Coumarin with in Silico Approaches2022
- Author(s)
 Yamada, T., Katsutani, N., Maruyama, T., Kawamura, T., Yamazaki, H., Murayama, N., Tong, W., Yamazoe, Y., and Hirose, A.
- Journal Title
 
 Food Safety
 
 Volume: 10 Issue: 3 Pages: 73-82
- DOI
 10.14252/foodsafetyfscj.D-21-00015
- ISSN
 2187-8404
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20K07139
[Journal Article] Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2´-, 3´-, 4´-, and 6-hydroxyflavanones by human cytochrome P450 enzymes.2021
- Author(s)
  Shimada, T., Nagayoshi, H., Murayama, N., Takenaka, S., Katahira, J., Kim, V., Kim, D., Komori, M., Yamazaki, H. ,Guengerich, F. P.
- Journal Title
  
  Xenobiotica
  
  Volume: 51 Issue: 2 Pages: 139-154
- DOI
  10.1080/00498254.2020.1836433
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07139
[Journal Article] Metabolic activation and deactivation of dietary-derived coumarin mediated by cytochrome P450 enzymes in rat and human liver preparations2021
- Author(s)
  Murayama, N., Yamazaki, H.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 8 Pages: 371-378
- DOI
  10.2131/jts.46.371
- NAID
  130008070939
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07139, KAKENHI-PROJECT-20K07164
[Journal Article] Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice2021
- Author(s)
  Miura Tomonori、Uehara Shotaro、Shimizu Makiko、Murayama Norie、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 11 Pages: 525-530
- DOI
  10.2131/jts.46.525
- NAID
  130008110376
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-20K06463, KAKENHI-PROJECT-20K07164
[Journal Article] Refined CYP2E1 Template; system to decipher the ligand-interactions2021
- Author(s)
  Yamazoe, Y., Murayama N., and Yoshinari, K.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 41 Pages: 1-12
- DOI
  10.1016/j.dmpk.2021.100413
- NAID
  210000188781
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07139
[Journal Article] Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models2021
- Author(s)
  Miura Tomonori、Kamiya Yusuke、Uehara Shotaro、Murayama Norie、Shimizu Makiko、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Xenobiotica
  
  Volume: － Issue: 6 Pages: 1-7
- DOI
  10.1080/00498254.2021.1908643
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16422, KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-20K07139
[Journal Article] Roles of cytochrome P450 2A6 in the oxidation of flavone, 4´-hydroxyflavone, and 4´-, 3´-, and 2´-methoxyflavones by human liver microsomes.2021
- Author(s)
  Nagayoshi, H., Murayama, N., Takenaka, S., Kim, V., Kim, D., Komori, M., Yamazaki, H., Guengerich, F. P., and Shimada, T.
- Journal Title
  
  Xenobiotica
  
  Volume: 51 Issue: 9 Pages: 995-1009
- DOI
  10.1080/00498254.2021.1950866
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07139
[Journal Article] Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity.2020
- Author(s)
  .Kamiya, Y., Takaku, H., Yamada, R., Akase, C., Abe, Y., Sekiguchi, Y., Murayama, N., Shimizu, M., Kitajima, M., Shono, F., Funatsu, K., and Yamazaki, H.
- Journal Title
  
  Toxicol. Rep.
  
  Volume: 149 Pages: 149-154
- DOI
  10.1016/j.toxrep.2020.01.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07139, KAKENHI-PROJECT-19K16422
[Journal Article] Different roles of human cytochrome P450 2C9 and 3A enzymes in diclofenac 4'- and 5-hydroxylations mediated by metabolically inactivated human hepatocytes in previously transplanted chimeric mice.2020
- Author(s)
  .Miura, T., Uehara, S., Shimizu, M., Murayama, N., Utoh, M., Suemizu, H., and Yamazaki, H.
- Journal Title
  
  Chem. Res. Toxicol.
  
  Volume: 33 Issue: 2 Pages: 634-639
- DOI
  10.1021/acs.chemrestox.9b00446
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07139, KAKENHI-PROJECT-20K07164
[Journal Article] Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential2020
- Author(s)
  Miura Tomonori、Shimizu Makiko、Uehara Shotaro、Yoshizawa Manae、Nakano Ayane、Yanagi Mayu、Kamiya Yusuke、Murayama Norie、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 33 Issue: 12 Pages: 3048-3053
- DOI
  10.1021/acs.chemrestox.0c00387
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07164, KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-19K16422
[Journal Article] Molecular characterization of functional UDP-glucuronosyltransferases 1A and 2B in common marmosets2020
- Author(s)
  Uno Yasuhiro、Uehara Shotaro、Inoue Takashi、Kawamura Shu、Murayama Norie、Nishikawa Miyu、Ikushiro Shinichi、Sasaki Erika、Yamazaki Hiroshi
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 172 Pages: 113748-113748
- DOI
  10.1016/j.bcp.2019.113748
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02159, KAKENHI-PROJECT-20K07139
[Journal Article] Genetic variants of UDP-glucuronosyltransferases 1A1, 1A6, and 1A9 in cynomolgus and rhesus macaques2020
- Author(s)
  Uno Yasuhiro、Mikami Takahiro、Tsukazaki Yasuko、Nakanishi Yasuharu、Murayama Norie、Ikushiro Shinichi、Tsusaki Hideshi、Yamazaki Hiroshi
- Journal Title
  
  Xenobiotica
  
  Volume: 51 Issue: 1 Pages: 115-121
- DOI
  10.1080/00498254.2020.1810367
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02159, KAKENHI-PROJECT-20K07139
[Journal Article] Preference for O-demethylation reactions in the oxidation of 2 -, 3 -, and 4 -methoxyflavones by human cytochrome P450 enzymes.2020
- Author(s)
  Nagayoshi, H., Murayama, N., Tsujino, M., Takenaka, S., Katahira, J., Kim, V., Kim, D., Komori, M., Yamazaki, H., Guengerich, F. P., and Shimada, T.
- Journal Title
  
  Xenobiotica
  
  Volume: 50 Issue: 10 Pages: 1158-1169
- DOI
  10.1080/00498254.2020.1759157
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07139
[Journal Article] Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model2020
- Author(s)
  47.Miura T, Kamiya Y, Hina S, Kobayashi Y, Murayama N, Shimizu M, Yamazaki H.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 11 Pages: 695-700
- DOI
  10.2131/jts.45.695
- NAID
  130007935150
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07139, KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-19K16422
[Journal Article] Interleukin-1β and Tumor Necrosis Factor-α Affect Cytochrome P450 Expression in Cynomolgus Macaque Hepatocytes2020
- Author(s)
  Yasuhiro Uno , Norie Murayama , Hiroshi Yamazaki
- Journal Title
  
  Drug metabolism and pharmacokinetiks
  
  Volume: -
- NAID
  50014558606
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08426
[Journal Article] Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model2020
- Author(s)
  Miura Tomonori、Uehara Shotaro、Shigeta Kazuki、Yoshizawa Manae、Kamiya Yusuke、Murayama Norie、Shimizu Makiko、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 34 Issue: 2 Pages: 522-528
- DOI
  10.1021/acs.chemrestox.0c00358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16422, KAKENHI-PROJECT-20K06463, KAKENHI-PROJECT-20K07164
[Journal Article] Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes2019
- Author(s)
  Nagayoshi, H. Murayama, N. Kakimoto, K. Tsujino, M. Takenaka, S. Katahira, J. Lim, Y. R. Kim, D. Yamazaki, H. Komori, M. Guengerich, F. P. Shimada, T.
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 32 Issue: 6 Pages: 1268-1280
- DOI
  10.1021/acs.chemrestox.9b00078
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425, KAKENHI-PROJECT-17K08426
[Journal Article] Molecular and Functional Characterization of N-Acetyltransferases NAT1 and NAT2 in Cynomolgus Macaque.2019
- Author(s)
  Uno Y, Murayama N, Yamazaki H.
- Journal Title
  
  Chem Res Toxicol.
  
  Volume: 31 Issue: 11 Pages: 1269-1276
- DOI
  10.1021/acs.chemrestox.8b00236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08426
[Journal Article] Steady-state human pharmacokinetics of monobutyl phthalate predicted by physiologically based pharmacokinetic modeling using single-dose data from humanized-liver mice orally administered with dibutyl phthalate2019
- Author(s)
  Miura, T. Uehara, S. Mizuno, S. Yoshizawa, M. Murayama, N. Kamiya, Y. Shimizu, M. Suemizu, H. Yamazaki, H.
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 32 Issue: 2 Pages: 333-340
- DOI
  10.1021/acs.chemrestox.8b00361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08425
[Journal Article] Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: potent inhibition by azelnidipine and manidipine2019
- Author(s)
  Noriaki Ikemura, Satoshi Yamaori, Chinatsu Kobayashi, Shinobu Kamijo, Norie Murayama, Hiroshi Yamazaki, Shigeru Ohmori
- Journal Title
  
  Chemico-Biological Interactions
  
  Volume: 306 Pages: 1-9
- DOI
  10.1016/j.cbi.2019.04.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07063, KAKENHI-PROJECT-17K08426
[Journal Article] Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone2018
- Author(s)
  Kakimoto Kensaku、Murayama Norie、Takenaka Shigeo、Nagayoshi Haruna、Lim Young-Ran、Kim Vitchan、Kim Donghak、Yamazaki Hiroshi、Komori Masayuki、Guengerich F. Peter、Shimada Tsutomu
- Journal Title
  
  Xenobiotica
  
  Volume: 48 Issue: 2 Pages: 1-12
- DOI
  10.1080/00498254.2018.1426133
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07770, KAKENHI-PROJECT-16K09119, KAKENHI-PROJECT-17K08426
[Journal Article] Chimeric mice with humanized liver as a model for testing organophosphate and carbamate pesticide exposure.2018
- Author(s)
  Suemizu, H., Kawai, K., Murayama, N., Nakamura, M., and Yamazaki, H.
- Journal Title
  
  Pest Manag.Sci.
  
  Volume: 74 Issue: 6 Pages: 1424-1430
- DOI
  10.1002/ps.4825
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08426
[Journal Article] Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies2018
- Author(s)
  Shimura, K., Ishii, Y., Takada, M., Uno, Y., Utoh, M., Iwasaki, K., and Yamazaki, H.
- Journal Title
  
  Biopharm. Drug Dispos.
  
  Volume: 39 Issue: 2 Pages: 115-121
- DOI
  10.1002/bdd.2115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425, KAKENHI-PROJECT-17K08426
[Journal Article] Cytochrome P450-dependent drug oxidation activities in commercially available hepatocytes derived from human induced pluripotent stem cells cultured for 3 weeks2018
- Author(s)
  Ｍｕｒａｙａｍａ　Ｎ，　ａｎｄ　Ｙａｍａｚａｋｉ　ｈ．
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 43 Issue: 4 Pages: 241-245
- DOI
  10.2131/jts.43.241
- NAID
  130006627486
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08426, KAKENHI-PROJECT-17K08425
[Journal Article] Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA2018
- Author(s)
  Murayama Norie、Suemizu Hiroshi、Uehara Shotaro、Kusama Takashi、Mitsui Marina、Kamiya Yusuke、Shimizu Makiko、Guengerich F. Peter、Yamazaki Hiroshi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 43 Issue: 6 Pages: 369-375
- DOI
  10.2131/jts.43.369
- NAID
  130007384441
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425, KAKENHI-PROJECT-17K08426
[Journal Article] Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques.2018
- Author(s)
  Uno, Y., Takahira, R., Murayama, N., Ishii, Y., Ikenaka, Y., Ishizuka, M., Yamazaki, H., and Ikushiro, S.
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 155 Pages: 172-181
- DOI
  10.1016/j.bcp.2018.06.027
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08426, KAKENHI-PROJECT-18H04132, KAKENHI-PROJECT-18H02159, KAKENHI-PROJECT-17K20038
[Journal Article] Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity2017
- Author(s)
  Murayama Norie、Kazuki Yasuhiro、Satoh Daisuke、Arata Kazuya、Harada Tasuku、Shibata Norio、Guengerich F. Peter、Yamazaki Hiroshi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 42 Issue: 3 Pages: 343-348
- DOI
  10.2131/jts.42.343
- NAID
  130006865647
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425, KAKENHI-PROJECT-17K08426
[Journal Article] Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity2017
- Author(s)
  Murayama, N., Kazuki, Y., Satoh, D., Arata, K., Harada, T., Shibata, N., Guengerich, F. P., and Yamazaki, H
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 42
- NAID
  130006865647
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460206
[Journal Article] Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).2015
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Murayama, N., Shimizu, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 43 Issue: 5 Pages: 735-742
- DOI
  10.1124/dmd.115.063594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18934, KAKENHI-PROJECT-25460198
[Journal Article] Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients.2015
- Author(s)
  Okubo M, Murayama N, Miura J, Chiba Y, Yamazaki H.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 93 Issue: 1 Pages: 104-109
- DOI
  10.1016/j.bcp.2014.11.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Regioselective hydroxylation of steroid hormones by human cytochromes P450.2015
- Author(s)
  Niwa T, Murayama N, Imagawa Y, Yamazaki H.
- Journal Title
  
  Drug Metab Rev.
  
  Volume: 13 Pages: 1-22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Human HepaRG cells can be cultured in hanging-drop plates for cytochrome P450 induction and function assays2015
- Author(s)
  Murayama, N., Usui, T., Slawny, N., Chesne, C., and Yamazaki, H
- Journal Title
  
  Drug Metab.Lett.
  
  Volume: 28 Issue: 1 Pages: 268-278
- DOI
  10.2174/1872312809666150119104806
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460206
[Journal Article] Human HepaRG Cells can be Cultured in Hanging-Drop Plates for Cytochrome P450 Induction and Function Assays.2015
- Author(s)
  Murayama N, Usui T, Slawny N, Chesne; C, Yamazaki H.
- Journal Title
  
  Drug Metab Lett
  
  Volume: 42 Issue: 9 Pages: 111-112
- DOI
  10.1124/dmd.114.059220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling2015
- Author(s)
  Miyaguchi,T.; Suemizu,H.; Shimizu,M.; Shida,S.; Nishiyama,S.; Takano,R.; Murayama,N.; Yamazaki,H.
- Journal Title
  
  Regul.Toxicol.Pharmacol.
  
  Volume: 72 Issue: 1 Pages: 71-76
- DOI
  10.1016/j.yrtph.2015.03.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460206
[Journal Article] Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing.2014
- Author(s)
  Shimizu M, Iwano S, Uno Y, Uehara S, Inoue T, Murayama N, Onodera J, Sasaki E, Yamazaki H.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 6 Pages: e100936-e100936
- DOI
  10.1371/journal.pone.0100936
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes p4502014
- Author(s)
  Yajima K, Uno Y, Murayama N, Uehara S, Shimizu M, Nakamura C, Iwasaki K, Utoh M, Yamazaki H
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 42 Issue: 5 Pages: 867-871
- DOI
  10.1124/dmd.113.056804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of pregnane X receptor2014
- Author(s)
  Murayama, N., van Beuningen, R., Suemizu, H., Guguen-Guillouzo, C., Shibata, N., Yajima, K., Utoh, M., Shimizu, M., Chesne, C., Nakamura, M., Guengerich, F. P., Houtman, R., and Yamazaki, H
- Journal Title
  
  Chem.Res.Toxicol
  
  Volume: 27 Issue: 2 Pages: 304-307
- DOI
  10.1021/tx4004374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200, KAKENHI-PROJECT-24590211, KAKENHI-PROJECT-26460206
[Journal Article] CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes2013
- Author(s)
  Okubo M, Murayama N, Shimizu M, Shimada T, Guengerich FP, Yamazaki H
- Journal Title
  
  J Toxicol Sci.
  
  Volume: 38 Pages: 349-354
- NAID
  10031158900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline2013
- Author(s)
  Utoh M, Murayama N, Uno Y, Onose Y, Hosaka S, Fujino H, Shimizu M, Iwasaki K, Yamazaki H
- Journal Title
  
  Xenobiotica
  
  Volume: 43 Issue: 12 Pages: 1037-1042
- DOI
  10.3109/00498254.2013.793874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Systematic identification and characterization of glutathione S-transferases in cynomolgus macaque2013
- Author(s)
  Uno Y, Murayama N, Kunori M, Yamazaki H
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 86 Issue: 5 Pages: 679-690
- DOI
  10.1016/j.bcp.2013.06.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling2013
- Author(s)
  Tsukada, A., Suemizu, H., Murayama, N., Takano, R., Shimizu, M., Nakamura, M., and Yamazaki, H
- Journal Title
  
  Regul.Toxicol.Pharmacol
  
  Volume: 65 Issue: 3 Pages: 316-324
- DOI
  10.1016/j.yrtph.2013.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200
[Journal Article] The CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes2013
- Author(s)
 Okubo, M., Murayama, N., Shimizu, M., Shimada, T., Guengerich, F. P., and Yamazaki, H.
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 38 Issue: 3 Pages: 349-354
- DOI
 10.2131/jts.38.349
- NAID
 10031158900
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23590200
[Journal Article] Metabolic activation of polycyclic aromatic hydrocarbons and aryl and heterocyclic amines by human cytochromes P450 2A13 and 2A62013
- Author(s)
  Shimada T, Murayama N, Yamazaki H, Tanaka K, Takenaka S, Komori M, Kim D, Guengerich FP
- Journal Title
  
  Chem Res Toxicol.
  
  Volume: 26 Issue: 4 Pages: 529-537
- DOI
  10.1021/tx3004906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] In vivo drug interactions of the teratogen thalidomide with midazolam: Heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice2013
- Author(s)
  Yamazaki, H., Suemizu, H., Murayama, N., Utoh, M., Shibata, N., Nakamura, M., and Guengerich, F. P.
- Journal Title
  
  Chem.Res.Toxicol.
  
  Volume: 26 Issue: 3 Pages: 486-489
- DOI
  10.1021/tx400008g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200, KAKENHI-PROJECT-24590211
[Journal Article] Characterization of microsomal glutathione S-transferases MGST1, MGST2, and MGST3 in cynomolgus macaque2013
- Author(s)
  Uno Y, Murayama N, Kunori M, Yamazaki H.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 41 Issue: 9 Pages: 1621-1625
- DOI
  10.1124/dmd.113.052977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] CYP2C76 Non-synonymous Variants in Cynomolgus and Rhesus Macaques2012
- Author(s)
 Uehara S, Murayama N, Yamazaki H, Uno Y
- Journal Title
 
 Drug Metabolism and Pharmacokinetics
 
 Volume: 27 Issue: 3 Pages: 344-348
- DOI
 10.2133/dmpk.DMPK-11-NT-118
- NAID
 130004463249
- ISSN
 1347-4367, 1880-0920
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-24590211
[Journal Article] Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs.2012
- Author(s)
  Mogi M, Toda A, Iwasaki K, Kusumoto S, Takehara H, Shimizu M, Murayama N, Izumi H, Utoh M, Yamazaki H.
- Journal Title
  
  J Toxicol Sci.
  
  Volume: 37 Pages: 1157-116
- NAID
  10031126020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] A rapid multiplex PCR assay that can reliably discriminate the cytochrome P450 2D6 whole-gene deletion allele from 2D6*10 alleles.2012
- Author(s)
  Okubo, M., Murayama, N., Miura, J., Shimizu, M., and Yamazakik, H
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 413 Issue: 19-20 Pages: 1675-1677
- DOI
  10.1016/j.cca.2012.05.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200, KAKENHI-PROJECT-24590211
[Journal Article] Binding of Diverse Environmental Chemicals with Human Cytochromes P450 2A13, 2A6, and 1B1 and Enzyme Inhibition2012
- Author(s)
  Shimada T, Kim D, Murayama N, Tanaka K, Takenaka S, Nagy LD, Folkman LM, Foroozesh MK, Komori M, Yamazaki H, Guengerich FP
- Journal Title
  
  Chem Res Toxicol.
  
  Volume: 26 Issue: 4 Pages: 517-523
- DOI
  10.1021/tx300492j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs2012
- Author(s)
  Mogi, M., Toda, A., Iwasaki, K., Kusumoto, S., Takahara, H., Shimizu, M., Murayama, N., Izumi, H., Utoh, M., and Yamazaki, H.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 37 Issue: 6 Pages: 1157-1164
- DOI
  10.2131/jts.37.1157
- NAID
  130004447016
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200
[Journal Article] Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation2012
- Author(s)
  Hosoi, Y., Uno, Y., Murayama, N., Fujino, H., Shukuya, M., Iwasaki, K., Shimizu, M., Utoh, M., and Yamazaki, H.
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 84 Issue: 12 Pages: 1691-1695
- DOI
  10.1016/j.bcp.2012.09.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200, KAKENHI-PROJECT-24590211
[Journal Article] Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants.2011
- Author(s)
  Akiyoshi, T.Saito, T., Murase, S., Miyazaki, M.Murayama, N.Yamazaki, H., Guengerich, F.P., Nakamura, K., Yamamoto, K., Ohtani, H
- Journal Title
  
  Drug Metab.Dispos.
  
  Volume: 39 Pages: 74-728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants2011
- Author(s)
  Akiyoshi, T. Saito, T., Murase, S., Miyazaki, M. Murayama, N., Yamazaki, H., Guengerich, F. P., Nakamura, K., Yamamoto, K., and Ohtani, H
- Journal Title
  
  Drug Metab. Dispos
  
  Volume: 39 Issue: 4 Pages: 724-728
- DOI
  10.1124/dmd.110.036780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177, KAKENHI-PROJECT-23590200
[Journal Article] Human liver enzymes responsible for metabolic elimination of tyramine, a vasopressor agent from daily food2011
- Author(s)
  Niwa, T., Murayama, N., Umeyama, H., Shimizu, M., and Yamazaki, H
- Journal Title
  
  Drug Metab. Lett
  
  Volume: 5 Pages: 216-219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] CYP2G2, pseudogenized in human, is expressed in nasal mucosa of cynomolgus monkey and encodes a functional drug-metabolizing2011
- Author(s)
  Uno Y, Uehara, S., Murayama, N., Yamazaki, H.
- Journal Title
  
  Drug Metab.Dispos.
  
  Volume: 39 Issue: 4 Pages: 717-723
- DOI
  10.1124/dmd.110.036574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system.2011
- Author(s)
  Nakamura, K., Mizutani, R., Sanbe, A., Enosawa, S., Kasahara, M., Nakagawa, A., Ejiri, Y., Murayama, N., Miyamoto, Y., Torii, T., Kusakawa, S., Yamauchi, J., Fukuda, M., Yamazaki, H., Tanoue.A.
- Journal Title
  
  J.Biosci.Bioeng
  
  Volume: 111 Pages: 78-84
- NAID
  110008440354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Human liver enzymes responsible for metabolic elimination of tyramine, a vasopressor agent from daily food2011
- Author(s)
  Niwa, T., Murayama, N., Umeyama, H., Shimizu, M., Yamazaki, H.
- Journal Title
  
  Drug Metab.Lett
  
  Volume: 5 Pages: 216-219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Individual Differences in Pharmacokinetics and Pharmacodynamics of Anesthetic Agent Propofol with Regard to CYP2B6 and UGT1A9 Genotype and Patient Age2011
- Author(s)
  Kansaku, F, Kumai, T., Sasaki, K., Yukozuka, M., Shimizu, M., Tateda, T., Murayama, N., Kobayashi, S., Yamazaki, H.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 26 Issue: 5 Pages: 532-537
- DOI
  10.2133/dmpk.DMPK-11-RG-039
- NAID
  130004463217
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177, KAKENHI-PROJECT-23790200
[Journal Article] Comparison of cytochrome P450 2D6 and variants in terms of drug oxidation rates and substrate inhibition2011
- Author(s)
  Niwa T, Murayama N, Yamazaki H
- Journal Title
  
  Curr Drug Metab
  
  Volume: 12 Pages: 412-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Species d ifference between cynomolgus monkeys and humans on cytochromes P450 2D and 3A-dependent drug oxidation activities in liver microsomes2011
- Author(s)
  Emoto, C., Iwasaki, K., Koizumi, R., Utoh, M., Murayama, N., Uno Y., and Yamazaki, H
- Journal Title
  
  J. Health Sci
  
  Volume: 57 Pages: 164-170
- NAID
  130000663115
- URL
  http://dx.doi.org/10.1248/jhs.57.164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Individual differences in pharmacokinetics and pharmacodynamics of anesthetic agent propofol with regard to CYP2B6 and UGT1A9 genotype and patient age2011
- Author(s)
  Kansaku F, Kumai T, Sasaki K, Yokozuka M, Shimizu M, Tateda T, Murayama N, Kobayashi S, Yamazaki H
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 26 Pages: 532-7
- NAID
  130004463217
- URL
  http://dx.doi.org/10.2133/dmpk.DMPK-11-RG-039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system2011
- Author(s)
  Nakamura, K., Mizutani, R., Sanbe, A., Enosawa, S., Kasahara, M., Nakagawa, A., Ejiri, Y., Murayama, N., Miyamoto, Y., Torii, T., Kusakawa, S., Yamauchi, J., Fukuda, M., Yamazaki, H., and Tanoue. A
- Journal Title
  
  J. Biosci. Bioeng
  
  Volume: 111 Pages: 78-84
- NAID
  110008440354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Immunochemical detection of cytoclirome P450 enzymes in liver microsomes of 27 cynomolgus monkeys2011
- Author(s)
  Uehara, S., Murayama, N., Nakanishi, Y., Zeldin, D.C., Yamazaki, H., Uno, Y.
- Journal Title
  
  J.Pharmacol.Exp.Ther
  
  Volume: 339 Issue: 2 Pages: 654-661
- DOI
  10.1124/jpet.111.185009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Species difference between cynomolgus monkeys and humans on cytochromes P450 2D and 3A-dependent drug oxidation activities in liver microsomes.2011
- Author(s)
  Emoto, C., Iwasaki, K., Koizumi, R., Utoh, M., Murayama, N., Uno Y., Yamazaki, H.
- Journal Title
  
  J.Health Sci.
  
  Volume: 57 Pages: 164-170
- NAID
  130000663115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Sorafenib and sunitinib, two anti-cancer drugs, inhibit CYP3A4-and activate CYP3A5-mediated midazolam 1' hydroxylation2011
- Author(s)
  Sugiyama, M., Fujita, K., Murayama, N., Akiyama, Y., Yamazaki, H., and Sasaki, Y
- Journal Title
  
  Drug Metab. Dispos
  
  Volume: 39 Issue: 5 Pages: 757-762
- DOI
  10.1124/dmd.110.037853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Stereoselectivity of human cytochrome p450 in metabolic and inhibitory activities2011
- Author(s)
  Niwa T, Murayama N, Yamazaki H
- Journal Title
  
  Curr Drug Metab
  
  Volume: 12 Pages: 549-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Mechanism-based inhibition of cytochrome P450 (CYP) 2A6 by chalepensin in recombinant systems, in human liver microsomes and mice in vivo2011
- Author(s)
  Ueng, Y.-F., Chen, C.-C., Chung, Y.-T, Liu, T.-Y., Chang, Y.-P., Lo, W.-S., Murayama, N., Yamazaki, H., Soucek, P., Chau, G.-Y., Chi, C.-W., Chen, R.-M., Li D.T.
- Journal Title
  
  Brit.J.Pharmacol.
  
  Volume: 163 Issue: 6 Pages: 1250-1262
- DOI
  10.1111/j.1476-5381.2011.01341.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177, KAKENHI-PROJECT-23590200
[Journal Article] Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate.2010
- Author(s)
  Chowdhury, G.., Murayama, N., Okada, Y., Uno, Y., Shimizu, M., Shibata, N., Guengerich, F.P., Yamazaki, H.
- Journal Title
  
  Chem.Res.Toxicol.
  
  Volume: 23 Pages: 1018-1024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling2010
- Author(s)
  Takano R, Murayama N, Horiuchi K, Kitajima M, Kumamoto M, Shono F, Yamazaki H
- Journal Title
  
  Regul Toxicol Pharmacol
  
  Volume: 58 Pages: 252-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate2010
- Author(s)
  Chowdhury, G., Murayama, N., Okada, Y., Uno, Y., Shimizu, M., Shibata, N., Guengerich, F. P., and Yamazaki, H
- Journal Title
  
  Chem. Res. Toxicol
  
  Volume: 23 Pages: 1018-1024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives2010
- Author(s)
  Shimada, T., Tanaka, K., Takenaka, T., Murayama, N., Martin, M. V., Foroozesh, M. K. Yamazaki, H., Guengerich, F. P, and Komori. M
- Journal Title
  
  Chem. Res. Toxicol.
  
  Volume: 23 Issue: 12 Pages: 1921-1935
- DOI
  10.1021/tx100286d
- NAID
  130004639911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Comparison of cytochrome P450 3A enzymes in cynomolgus monkeys and humans2010
- Author(s)
  Iwasaki, K., Murayama, N., Koizumi, R., Uno, Y., Yamazaki, H.
- Journal Title
  
  Drug Metab.Pharmacokinet. (印刷中)
- NAID
  10027583437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Blood concentrations of 1, 4-dioxane in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling.2010
- Author(s)
  Takano, R., Murayama, N., Horiuchi, K., Kitajima, M., Shono F., Yamazaki, H..
- Journal Title
  
  J.Health Sci.
  
  Volume: 56 Pages: 557-565
- NAID
  130000425091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies2009
- Author(s)
  Murayama, N., Kaneko, N., Horiuchi, K., Ohyama, K., Shimizu, M., Ito, K., Yamazaki, H
- Journal Title
  
  Drug Metab.Pharmacokinet. 24
  
  Pages: 404-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity : A structure-function relationship study2009
- Author(s)
  Shimada, T., Tanaka, K.Takenaka, S.Foroozesh, M.K., Murayama, N., Yamazaki, H., Guengerich, F.P., Komori, M.Murayama, N., Kaneko, N., Horiuchi, K., Ohyama, K., Shimizu, M., Ito, K., Yamazaki, H
- Journal Title
  
  Chem.Res.Toxicol. 22
  
  Pages: 1325-1333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Effects of histidine-tag on recombinant human cytochrome P450 3A5 catalytic activity in reconstitution systems2009
- Author(s)
  Emoto, C., Murayama, N., Wakiya, S., Yamazaki, H.
- Journal Title
  
  Drug Metab.Lett.t. 3
  
  Pages: 207-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Oxidation of endobiotics mediated by xenobiotic-metabolizing forms of human cytochrome P4502009
- Author(s)
  Niwa, T., Murayama, N., Yamazaki, H.
- Journal Title
  
  Curr.Drug Metab. 10
  
  Pages: 700-712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug discovery stage: The impact of plasma and microsomal binding2009
- Author(s)
  Chie Emoto, Norie Murayama Rostami-Hodjegan, A. and Hiroshi Yamazaki
- Journal Title
  
  Xenobiotica 39
  
  Pages: 227-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug discovery stage : The impact of plasma and microsomal binding2009
- Author(s)
  Emoto, C., Murayama, N. Rostami-Hodjegan, A., Yamazaki, H
- Journal Title
  
  Xenobiotica 39
  
  Pages: 227-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug discovery stage : The impact of plasma and microsomal binding2009
- Author(s)
  Emoto, C., Murayama, N.Rostami-Hodjegan, A., Yamazaki, H.
- Journal Title
  
  Xenobiotica 39
  
  Pages: 227-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Comparison of kinetic parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A52008
- Author(s)
  Niwa, T., Murayama, N., Emoto, C., and Yamazaki, H
- Journal Title
  
  Current Drug Metabolism 9
  
  Pages: 20-32
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Comparison of kinetic parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A52008
- Author(s)
  Niwa, T., Murayama, N., Emoto, C., and Yamazaki, H
- Journal Title
  
  Current Drug Metabolism 9
  
  Pages: 20-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Effects of enzyme sources on midazolam 1'-hydroxylation activity catalyzed by recombinant cytochrome P450 3A4 in combination with NADPH-cytochrome P450 reductase.2008
- Author(s)
  Emoto, C., Murayama, N., Yamazaki, H.
- Journal Title
  
  Drug Metab. Lett. 2
  
  Pages: 190-192
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in Inhibiting catalytic activity2008
- Author(s)
  Shimada, T. Murayama, N., Tanaka, K., Takenaka, S., Imai, Y., Hopkins, E., Foroozesh, M. K., Al worth, W. L., Yamazaki, H., Guengerich, F. P, Komori, M
- Journal Title
  
  Chem. Res Toxicol 21
  
  Pages: 2313-2323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Heterotropic cooperativity in oxidation mediated by cytochrome P4502008
- Author(s)
  Niwa, T., Murayama, N., and Yamazaki, H
- Journal Title
  
  Curr.Drug Metab. 9
  
  Pages: 453-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Comparison of kinetic parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A52008
- Author(s)
  Niwa, T., Murayama, N., Emoto, C., and Yamazaki.H
- Journal Title
  
  Current Drug Metabolism 9
  
  Pages: 20-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effects of enzyme sources on midazolam 1'-hydroxylation activity catalyzed by recombinant cytochrome P450 3A4 in combination with NADPH- cyto- chrome P450 reductase2008
- Author(s)
  Chie Emoto, Norie Murayama, and Hiroshi Yamazaki
- Journal Title
  
  Drug Metab.Lett., 2
  
  Pages: 190-192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors.2007
- Author(s)
  Shimada, T., Murayama, N., Okuda, K., Funae, Y., Yamazaki, H., Guengerich, F.P
- Journal Title
  
  Chem.Res.Toxicol 20
  
  Pages: 489-496
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3(FMO3) on N- and S-oxygenation activities2007
- Author(s)
  Shimada, T., Murayama, N., Okuda, K., Funae, Y., Yamazaki, H., and Guengerich, F.P.
- Journal Title
  
  Chem.Res.Toxicol. 20
  
  Pages: 489-496
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Roles of CYP3A4 and CYP2C19 in methylhydroxylated and N-oxidized metabolite for mation from voriconazole,a new anti-fungal agent,in human liver microsomes.2007
- Author(s)
  Murayama, N., Imai, N., Nakane, T., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Biochem.Pharmacol. 73
  
  Pages: 2020-2026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Genein a Japanese Cohort2007
- Author(s)
  Shimizu, M.Tomioka, S., Murayama, N.and Yamazaki, H.
- Journal Title
  
  Drug Metab.Pharmacokinet. 22
  
  Pages: 61-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3(FMO3)on N- and S-oxygenation activities2007
- Author(s)
  Shimizu, M., Yano, H., Nagashima, S., Murayama, N., Zhang, J., Cashman, J.R. and Yamazaki, H
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 328-330
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors.2007
- Author(s)
  Shimada, T., Murayama, N., Okuda, K., Funae, Y., Yamazaki, H., Guengerich, F.P
- Journal Title
  
  Chem. Res. Toxicol., 20
  
  Pages: 489-496
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Different mechanisms for inhibition of human cytochromes P450 1A1,1A2,and IBl by polycyclic aromatic inhibitors.2007
- Author(s)
  Shimada, T., Murayama, N., Okuda, K., Funae, Y., Yamazaki.H., and Guengerich, F.P.
- Journal Title
  
  Chem.Res.Toxicol. 20
  
  Pages: 489-496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Involvement of human cytochrome P450 2B6 in the ω- and 4-hydroxylation of the anesthetic agent propofol2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M., Guengerich, F.P., and Yamazaki, H.
- Journal Title
  
  Current Drug Metabolism 37
  
  Pages: 717-724
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Involvement of human cytochrome P450 2B6 in the □-and 4-hydroxylation of the a nesthetic agent propofol.2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M., Guengerich, F.P., and Yamazaki, H.
- Journal Title
  
  Xenobiotica 37
  
  Pages: 717-724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Involvement of human cytochrome P450 2B6 in the ω- and 4-hydroxylation of the anesthetic agent propofol2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M., Guengerich, F.P., Yamazaki, H
- Journal Title
  
  Xenobiotica 37
  
  Pages: 717-724
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3(FMO3) on N- and S-oxygenation activities2007
- Author(s)
  Shimizu, M., Yano, H., Nagashima, S., Murayama, N., Zhang, J., Cashman, J.R. Yamazaki, H
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 328-330
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3(FMO3)on N-and S-oxygenation activities2007
- Author(s)
  Shimizu, M., Yano, H., Nagashima, S.Murayama, N., Zhang, J., Cashman, J.R.and Yamazaki, H
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 328-330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Gene in a Japanese Cohort2007
- Author(s)
  Shimizu, M., Tomioka, S., Murayama, N. and Yamazaki, H.
- Journal Title
  
  Drug Metab.Pharmacokinet. 22
  
  Pages: 61-64
- NAID
  10018733032
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Roles of CYP3A4 and CYP2C19 in methylhydroxylated and N-oxidized metabolite formation from voriconazole,a new anti-fungal agent,in humanlive rmicrosomes.2007
- Author(s)
  Murayama, N., Imai, N., Nakane, T., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Biochem.Pharmacol 73
  
  Pages: 2020-2026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3 (FMO3) on N-and S-oxygenation activities2007
- Author(s)
  Shimizu, M., Yano, H., Nagashima, S.Murayama, N., Zhang, J., Cashman, J.R. and Yamazaki, H
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 328-330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Roles of CYP3A4 and CYP2C19 in methylhydroxylated and N-oxidized metabolite for mation from voriconazole,a new anti-fungal agent,in human liver microsomes2007
- Author(s)
  Murayama, N., Imai, N., Nakane, T., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Biochem.Pharmacol. 73
  
  Pages: 2020-2026
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Different mechanisms for inhibition of human cytochromes P450 1A1,1A2,and 1B1 by polycyclic aromatic inhibitors2007
- Author(s)
  Shimada, T., Murayama, N., Okuda, K., Funae, Y., Yamazaki, H., and Guengerich, F.P
- Journal Title
  
  Chem.Res.Toxicol. 20
  
  Pages: 489-496
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Gene in a Japanese Cohort2007
- Author(s)
  Shimizu, M.Tbmioka, S., Murayama, N. and Yamazaki, H.
- Journal Title
  
  Drug Metab.Pharmacokinet. 22
  
  Pages: 61-64
- NAID
  10018733032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Roles of CYP3A4 and CYP2C19 in methylhydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes2007
- Author(s)
  Murayama, N., Imai, N., Nakane, T., Shimizu, M., Yamazaki, H
- Journal Title
  
  Biochem.Pharmacol 73
  
  Pages: 2020-2026
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Guengerich, F.P., and Yamazaki, H. Involvement of human cytochrome P450 2B6 in the omega- and 4-hydroxylation of the anesthetic agent propofol2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M
- Journal Title
  
  Xenobiotica 37
  
  Pages: 717-724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] lnvolvement of human cytochrome P450 2B6 in the ω-and 4-hydroxylation of the anesthetic agent propofol.2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M., Guengerich, F.P., and Yamazaki, H.
- Journal Title
  
  Current Drug Metabolism 37
  
  Pages: 717-724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Amperometric detection and characterization of exocytotic events in single ventral midbrain dopaminergic neuron.2006
- Author(s)
  Yamada, S., Sekiguti, M., Murayama, N., Sasakawa, N., Kumakura, K.
- Journal Title
  
  J.Pharmacol.Sci.supplement I 100
  
  Pages: 194-194
- Data Source
  KAKENHI-PROJECT-16590205
[Journal Article] Effects of epigallocatechin-3 gallate, a green tea catechin, on the regulatory mechanisms of exocytosis in adrenal chromaffin cells.2006
- Author(s)
  Murayama, N., Otsuka, A., Sasakawa, N., Kumakura, K.
- Journal Title
  
  J.Pharmacol.Sci.supplement I 100
  
  Pages: 158-158
- Data Source
  KAKENHI-PROJECT-16590205
[Journal Article] Effects of epigallocatechin-3 gallate, a green tea catechin, on the regulatory mechanisms of exocytosis in adrenal chromaffin cells2006
- Author(s)
  Norie Murayama
- Journal Title
  
  J.Pharmacol.Sci., 100(Suppl.1),
  
  Pages: 158-158
- Data Source
  KAKENHI-PROJECT-15200030
[Journal Article] Rat cytochrome P450 2C11 in liver microsomes involved in oxidation of anesthetic agent propofol and deactivated by prior treatment with propofol2006
- Author(s)
  Yamazaki, H., Shimizu, M., Nagashima, T., Minoshima, M., Murayama, N., Drug Metab.Dispos.
- Journal Title
  
  Drug Metab. Dispos 34
  
  Pages: 1803-1805
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effects of epigallocatechin-3 gallate, a green tea catechin,on the regulatory mechanisms of exocytosis in adrenal chromaffin cells2006
- Author(s)
  Murayama, N., et. al.
- Journal Title
  
  J.Pharmacol.Sci., supplement I 100
  
  Pages: 158-158
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590205
[Journal Article] Rat cytochrome P450 2C11 in liver microsomes involved in oxidation of anesthetic agent propofol and deactivated by prior treatment with propofol2006
- Author(s)
  Yamazaki, H., Shimizu, M., Nagashima, T., Minoshima, M. and Murayama, N. Drug Metab.Dispos.
- Journal Title
  
  Drug Metab.Dispos 34
  
  Pages: 1803-1805
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Amperometric detection and characterization of exocytotic events in single ventral midbrain dopaminergic neuron.2006
- Author(s)
  Yamada, S., Sekiguti, M., Murayama, N., Sasakawa N. Kumakura, K.
- Journal Title
  
  J. Pharmacol. Sci., supplement I 100
  
  Pages: 194-194
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590205
[Journal Article] Effects of epigallocatechin-3 gallate, a green tea catechin, on the regulatory mechanisms of exocytosis in adrenal chromaffin cells.2006
- Author(s)
  Murayama, N., Otsuka, A., Sasakawa, N., Kumakura, K.
- Journal Title
  
  J. Pharmacol. Sci., supplement I 100
  
  Pages: 158-158
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590205
[Journal Article] Characterization of exocytotic events from single PC12 cells : Amerometric studies in native PC12h, DA-loadedPC12h cell and bovine adrenal chromaffin cells2005
- Author(s)
  Sasakawa N, Murayama N, Kumakura K.
- Journal Title
  
  Mol.Cell.Neurobiol. (in press)
- Data Source
  KAKENHI-PROJECT-16590205
[Journal Article] Characterization of a single exocytotic event in digitonin-permeabilized adrenal chromaffin cells.2005
- Author(s)
  Sasakawa N, Murayama N, Kumakura K.
- Journal Title
  
  J.Pharmacol.Sci.Supplement I 97
  
  Pages: 169-169
- Data Source
  KAKENHI-PROJECT-16590205
[Journal Article] A single exocytotic event in digitonin-permeabilized adrenal chromaffin cells.2005
- Author(s)
  Sasakawa, N., Murayama, N., Kumakura, K.
- Journal Title
  
  Bull. Japanese Soci. Neurochem. 44
  
  Pages: 209-209
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590205
[Journal Article] Characterization of exocytotic events from single PC12 cells : Amerometric studies in native PC12h, DA-loadedPC12h cell and bovine adrenal chromaffin cells2005
- Author(s)
  Sasakawa, N., Murayama, N., Kumakura, K.
- Journal Title
  
  Mol.Cell.Neurobiol. 25
  
  Pages: 777-787
- Data Source
  KAKENHI-PROJECT-16590205
[Journal Article] Spatio-Temporal regulation of Neurotransmitter release by PKC ; studies in adrenal chromaffin cells.2005
- Author(s)
  Kumakura, K., Sasakawa, N., Murayama, N., Ohara-Imaizumi, M.
- Journal Title
  
  Crit. Rev, in Neurobiol. 16
  
  Pages: 173-179
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590205
[Journal Article] Characterization of exocytotic events from single PC12 cells : Amperometric studies in native PC12h. DA-loaded PC12h and adrenal chromaffin cells.2005
- Author(s)
  Sasakawa, N., Murayama, N. and Kumakura K.
- Journal Title
  
  Cell, and Mol. Neurobiol. 25
  
  Pages: 777-787
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590205
[Journal Article] A single exocytotic event in digitonin-permeabilized adrenal chromaffin cells.2005
- Author(s)
  Sasakawa, N., Murayama, N., Kumakura, K.
- Journal Title
  
  Bull.Japanese Soci.Neurochem. 44
  
  Pages: 209-209
- Data Source
  KAKENHI-PROJECT-16590205
[Journal Article] Characterization of exocytotic events from single PC12 cells : Amperometric studies in native PS12h, DA-loaded PC12h and bovine adrenal chromaffin cells2005
- Author(s)
  N., Sasakawa, N., Murayama, K., Kumakura
- Journal Title
  
  Cell Mol. Neurobiol 25
  
  Pages: 774-787
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Journal Article] Spatio-temporal regulation of neurotransmitter release by PKC ; studies in adrenal chromaffin cells.2004
- Author(s)
  Kumakura K, Sasakawa N, Murayama N, Ohara-Imaizumi M.
- Journal Title
  
  Crit.Rev.Neurobiol. 16
  
  Pages: 173-179
- Data Source
  KAKENHI-PROJECT-16590205
[Journal Article] Spatio-temporal regulation of neurotransmitter release by PKC ; studies in adrenal chromaffin cells2004
- Author(s)
  K, . Kumakura, N., Sasakawa, N., Murayama, M., Ohara-Imaizumi
- Journal Title
  
  Critical Reviews in Neurobiol 16
  
  Pages: 169-175
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Journal Article] Characteristic regulation of exocytotoic events by PKC isoforms in single adrenal chromaffin cells.2004
- Author(s)
  Sasakawa N, Murayama N, Kumakura K
- Journal Title
  
  J.Pharmacol.Sci.supplement I 94
  
  Pages: 191-191
- Data Source
  KAKENHI-PROJECT-16590205
[Journal Article] Comparison of kinetic 2008. parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A5
- Author(s)
  Niwa, T., Murayama, N., Emoto, C., Yamazaki, H.
- Journal Title
  
  Current Drug Metabolism 9
  
  Pages: 20-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] 簡易生理学的薬物動態モデルによるチトクロム P450 3A4/5 遺伝子多型患者でのアトルバスタチンおよびカルバマゼピン血中動態予測2023
- Author(s)
  佐藤翼、安達昂一郎、村山典恵、清水万紀子、田中庸一、斎藤嘉朗、山崎浩史
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] イヌ肝と小腸に発現するチトクロム4503A分子種の同定とそれらの機能解析2022
- Author(s)
  村山典恵、野田優太朗、軸屋志織、宇野泰広、山崎浩史現するチトクロム4503A分子種の同定とそれらの機能解析
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07139
[Presentation] 物質のヒト体内動態を規定する生理学的薬物動態モデル重要パラメータの予測と消化管吸収性推定の精緻化2022
- Author(s)
  神矢佑輔、佐藤翼、森國紗帆、内海正義、三浦智徳、村山典恵、清水万紀子、半田健太郎、北島正人、庄野文章、山崎浩史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07139
[Presentation] 物質のヒト体内動態を規定する生理学的薬物動態モデル重要パラメータの予測と消化管吸収性推定の精緻化2022
- Author(s)
  神矢佑輔、佐藤翼、森國紗帆、内海正義、三浦智徳、村山典恵、清水万紀子、半田健太郎、北島正人、庄野文章、山崎浩史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] CYP2C19の代謝キネティクスにおける*23変異アレルの影響とその基質間差の要因2021
- Author(s)
  渡辺大智、粟田祐作、秋好健志、関博行、今岡鮎子、村山典恵、山崎浩史、下地みゆき、中村克徳、大谷壽一
- Organizer
  医療薬学フォーラム
- Data Source
  KAKENHI-PROJECT-20K07139
[Presentation] Roles of human Cytochrome P450 enzymes in drug oxidation: Comparison of in vitro and in vivo system results2019
- Author(s)
  Hiroshi Yamazaki and Norie Murayama
- Organizer
  21th International Conference on Cytochrome P450
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] Functional and Molecular Characterization of UDP-glucuronosyltransferase 1A Enzymes in Common Marmosets2019
- Author(s)
  Norie Murayama, Shotaro Uehara, Shu Kawamura, Miyu Nishikawa, Shinichi Ikushiro, Yasuhiro Uno, and Hiroshi Yamazaki
- Organizer
  第34回日本薬物動態学会
- Data Source
  KAKENHI-PROJECT-17K08426
[Presentation] Cytochrome P450 3A Enzyme-dependent Thalidomide Toxicity and Inducibility in Cultured Human Placental Cells2018
- Author(s)
  Norie Murayama, F. Peter Guengerich, and Hiroshi Yamazaki
- Organizer
  22nd North American ISSX Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08426
[Presentation] Activities of UDP-glucuronosyltransferase 1A/2B Enzymes in Marmoset Liver Microsomes: Comparison with Cynomolgus Macaques and Humans2018
- Author(s)
  Norie Murayama, Shotaro Uehara, Yu Ishii, Shunsuke Onozeki, Shu Kawamura, Shinichi Ikushiro, Yasuhiro Uno, Hiroshi Yamazaki
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08426
[Presentation] 化学物質の肝毒性評価を目指した生理学的薬物動態モデルを用いたラット体内動態予測2018
- Author(s)
  村山典恵、岩崎美友、小林由惟、大西潮、吉沢愛映、水野紗和、中里真悠子、中村仁美、
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K08426
[Presentation] サリドマイドは核内レセプターを介してヒト肝薬物代謝酵素を誘導する2014
- Author(s)
  村山典恵、矢島加奈子、Christophe Chesné、Rene Houtman、山崎浩史
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学　黒髪キャンパス、他　（熊本市）
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] 抗うつ薬ミルタザピンの代謝消失に影響を与える因子2014
- Author(s)
  大久保真穂、村山典恵、三浦淳、千葉泰二、山崎浩史
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学　黒髪キャンパス、他　（熊本市）
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] Function of Thalidomide for Potential Inducer of Drug Metabolizing Enzymes in Human Livers2013
- Author(s)
  Norie Murayama, Hiroshi Suemizu, Kanako Yajima, Masahiro Utoh, Christiane Guguen-Guillouzo, Christophe Chesné, René Houtman, Rinie van Beuningen, Norio Shibata, Masato Nakamura, and Hiroshi Yamazaki
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Westin Harbour Castle Hotel (Tronto, Canada)
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] ヒト及びサル肝P450に認められるワルファリン代謝の立体選択性2013
- Author(s)
  村山典恵、宇野泰広、細井祥生、岩崎一秀、清水万紀子、鵜藤雅裕、山崎浩史
- Organizer
  日本学学会第133年会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] P4503A4タンパク発現量および薬物代謝酵素活性におよぼすCYP3A4:22遺伝子多型の影響2013
- Author(s)
  大久保真穂、村山典恵、清水万紀子、山崎浩史
- Organizer
  日本学学会第133年会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] Function of Thalidomide for Potential Inducer of Drug Metabolizing Enzymes in Human Livers2013
- Author(s)
  Norie Murayama, Hiroshi Suemizu, Kanako Yajima, Masahiro Utoh, Masato Nakamura, and Hiroshi Yamazaki
- Organizer
  28th JSSX Annual Metting
- Place of Presentation
  タワーホール船堀　（江戸川区）
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] チオカルバメート系除草剤モリネートの代謝消失における種差の検討2012
- Author(s)
  村山典恵、山下真直、塚田藍、末水洋志、中村雅登、高野良治、清水万紀子、山崎浩史
- Organizer
  日本薬学会第132回年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Induction of cytochrome P450 3A enzymes by thalidomide in human hepatic cells2012
- Author(s)
  Norie Murayama, Kanako Yajima Masahiro Utho, and Hiroshi Yamazaki
- Organizer
  JSSX
- Place of Presentation
  タワーホール船堀(千葉)
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] チオカルバメート系除草剤モリネートの代謝消失における種差の検討2012
- Author(s)
  村山典恵、山下真直、塚田藍、高野良治、末水洋志、中村雅登、清水万紀子、山崎浩史
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌市・北海道大学・高等教育推進機構
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] 肝試料画分を考慮した化学物質のヒト生理学的薬物動態モデルの精緻化2011
- Author(s)
  村山典恵、國兼絵里子、塚田藍、高野良治、北島正人、清水万紀子、池田敏彦、山崎浩史
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Drug Interaction of Thalidomide with Midazolam in Human Hepatoma Cell Line System with Differentiated HepaRG Cryopreserved2011
- Author(s)
 Norie Murayama, Kanako Yajima, Makiko Shimizu, Masahiro Utoh, Hiroshi Yamazaki
- Organizer
 17^<th> Notth America ISSX Meeting
- Place of Presentation
 Atranta, USA, Hotel Hirtone
- Year and Date
 2011-10-17
- Data Source
 KAKENHI-PROJECT-21590177
[Presentation] Drug metabolism in human hepatomacell line system with differentiated HepaRG cryopreserved2011
- Author(s)
  Norie Murayama, Kanako Yajima, Makiko Shimizu, Masahiro Utoh, and Hiroshi Yamazaki
- Organizer
  26th JSSX Annual Meeting
- Place of Presentation
  広島
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Drug Metabolism In Human Hepatoma Cell Line System with Differentiated HepaRG Cryopresorved2011
- Author(s)
  Norie Murayama, Kanako Yajima, Makiko Shimizu, Masahiro Utoh, Hiroshi Yamazaki
- Organizer
  JSSX
- Place of Presentation
  広島市・国際会議場
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] 肝試料画分を考慮した化学物質のヒト生理学的薬物動態モデルの精緻化2011
- Author(s)
  村山典恵、國兼絵里子、塚田藍、高野良治、北島正人、清水万紀子、山崎浩史
- Organizer
  日本薬学会第131年会
- Place of Presentation
  要旨集上にて発表
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Drug interactions of thalidomide with midazolam in human hepatoma cell line system with differentiated HepaRG cryopreserved2011
- Author(s)
  Norie Murayama, Kanako Yajima, Makiko Shimizu, Masahiro Utoh, and Hiroshi Yamazaki
- Organizer
  17 th North American regional ISSX meeting
- Place of Presentation
  Atlanta, USA
- Year and Date
  2011-10-18
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Individual differences in pharmacokinetics and pharmacodynamics of anesthetic agent propofol in patients genotyped for CYP2B6 and UGT1A92010
- Author(s)
  Hiroshi Yamazaki, Toshio Kumai, Kuniharu Sasaki, Makito Yokozuka, Makiko Shimizu, Tadashi Tateda, Norie Murayama and Shinichi Kobayashi
- Organizer
  ISSX Workshop on Genetic Polymorphisms in Drug Disposition
- Place of Presentation
  Indianapolis, USA
- Year and Date
  2010-04-11
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] ヒトと実験動物間で認められる薬物代謝酵素機能の種差2010
- Author(s)
  村山典恵, 今村裕樹, 大久保真穂, 國兼絵里子, 松本史彦, 小野瀬優維, 佐々木国玄, 清水万紀子, 山崎浩史
- Organizer
  日本薬学会第130回総会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] An improved method to assess internal radiation exposure in humans using in vivo and in vitro animal pharmacokinetic data2010
- Author(s)
  Toshihiko Ikeda, Norie Murayama and Hiroshi Yamazaki
- Organizer
  25th JSSX Annual Meeting
- Place of Presentation
  埼玉
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Impact of genetic polymorphism of the CYP3A5 appeared in the metabolism of and inhibition by voriconazoke in a Japanese population2009
- Author(s)
  村山典恵, 清水万紀子, 山崎浩史
- Organizer
  日本薬物動態学会
- Place of Presentation
  京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Impact of cytochrome p450 3A5 expression in human livers on drug interactions of anti-fungal agents with midazolam2009
- Author(s)
  村山典恵, 中本美那子, 清水万紀子, 山崎浩史
- Organizer
  16th International Conference on Cytochrome P450 ～Biochemistry, Biophysics, Biotechnology～
- Place of Presentation
  沖縄
- Year and Date
  2009-06-21
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] アゾール系抗真菌薬の阻害効果とCYP3A5遺伝子多型との関連性2009
- Author(s)
  村山典恵、中本実那子、岡田雄介、清水万紀子、山崎浩史
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] INDIVIDUAL DIFFERENCES OF OXIDATIVE METABOLISM OF MEDICINES AND THEIR CLINICAL SIGNIFICANCE2008
- Author(s)
  Hiroshi Yamazaki, ^a Dimitrios Zonios, ^b Makiko Shimizu, ^a John Bennett, ^b Norie Murayama
- Organizer
  Pan-Pacific International Partnership Conference on Pharm aceutical and Life Sciences The 4th US-Japan Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] レポーターアッセイを用いたFMO3遺伝子の転写調節機構2008
- Author(s)
  清水万紀子, 永島里美, 村山典恵, 山崎浩史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒト肝チトクロームP450触媒活性に及ぼすサリドマイドの影響2008
- Author(s)
  村山典恵, 柳田千裕, 清水万紀子, 山崎浩史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Inhibitory effects of thalidomide on human liver microsomal Cytochrome P450-mediated drug oxidation activities2008
- Author(s)
  Norie, Murayama, Chihiro, Yanagida, Makiko, Shimizu, Hiroshi, Yamazaki
- Organizer
  128th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] INDIVIDUAL DIFFERENCES OF OXIDATIVE METABOLISM OF MEDICINES AND THEIR CLINICAL SIGNIFICANCE2008
- Author(s)
  Hiroshi, Yamazaki, Dimitrios, Zonios, Makiko, Shimizu, John, Bennett, Node, Murayama
- Organizer
  Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences The 4th US-Japan Joint Conference
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Individual differences of levels of voriconazole and its oxidative metabolites in patients2008
- Author(s)
  Node, Murayama, Dimitrios, Zonios, Makiko, Shimizu, John, Bennett, Hiroshi, Yamazaki
- Organizer
  128th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] INDIVIDUAL DIFFERENCES O FOXIDATIVEME TABOLISM OF MEDICINES AND THEIR CLINICAL SIGNIFICANCE2008
- Author(s)
  Hiroshi Yamazaki, ^a DimitriosZonios, ^b MakikoShimizu, ^a JohnBennett, ^b NorieMurayama
- Organizer
  Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences The 4th US-Japan Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒト肝チトクロームP450触媒活性に及ぼすサリドマイドの影響2008
- Author(s)
  永島里美, 清水万紀子, 村山典恵, 山崎浩史
- Organizer
  目本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒト肝におけるフラビン含有モノオキシゲナーゼ3発現量の個人差の解析2008
- Author(s)
  永島里美, 清水万紀子, 村山典恵, 山崎浩史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒト肝チトクロームP450触媒活性に及ぼすサリドマイドの影響2008
- Author(s)
  村山典恵、柳田千裕、清水万紀子、山崎浩史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] 抗真菌薬ボリコナゾールの酸化的代謝物生成の個人差について2008
- Author(s)
  山崎浩史, 清水万紀子, 村山典恵
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] INDIVIDUAL DIFFERENCES OF OXIDATIVE METABOLISM OF MEDICINES AND THEIR CLINICAL SIGNIFICANCE2008
- Author(s)
  Hiroshi Yamazaki, a Dimitrios Zonios, b Makiko Shimizu, a John Bennett, b Norie Murayama
- Organizer
  Pan-Pacific International Partnership Conference on Pharm aceutical and Life Sciences The 4th US-Japan Joint Conference
- Place of Presentation
  名古屋
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒト肝チトクロムP450による全身麻酔薬プロポフォールの代謝について2008
- Author(s)
  中本実那子、村山典恵、簑島正樹、清水万紀子、山崎浩史
- Organizer
  医療薬学フォーラム2008 第16回クリニカルファーマシーシンポジウム
- Place of Presentation
  船橋
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] ヒト肝チトクロムP450による全身性麻酔薬プロポフォールの代謝について2008
- Author(s)
  中本実那子, 村山典恵, 簑島正樹, 清水万紀子, 山崎浩史
- Organizer
  医療薬学フォーラム2008
- Place of Presentation
  船橋
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Analysis of transcriptional regulation of the human flavin-containing monooxygenase 3(FMO3) gene using the reporter assay Individual differences of flavin-containing monooxygenase S(FMO3) expression levels in human livers2008
- Author(s)
  Makiko, Shimizu, Satomi, Nagashima, Norie, Murayama, Hiroshi, Yamazaki
- Organizer
  128th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Voriconazole methyl hydroxylation and N-oxidation catalyzed by CYP3A4 and CYP2C19 in human liver microsomes2008
- Author(s)
  Hiroshi, Yamazaki, Node, Murayama, Naoko, Imai, Takahisa, Nakane, Makiko, Shimizu
- Organizer
  128th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] 全身性麻酔薬プロポフォールの酸化的代謝における個人差2008
- Author(s)
  中本実那子、村山典恵、神作文康、柏田雅也、簑島正樹、清水万紀子、山崎浩史
- Organizer
  第29回日本臨床薬理学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] アゾール系抗真菌薬の薬物酸化的代謝に及ぼす影響2008
- Author(s)
  中本実那子、村山典恵、清水万紀子、山崎浩史
- Organizer
  第56回聖マリアンナ医学会学術集会
- Place of Presentation
  川崎
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] "Micromini" Pigs as a Possible New Animal Model For Humans in Non-Clinical Study2008
- Author(s)
 Norie Murayama, Naoki Kaneko, Kana Horiuchi, Makiko Shimizu, Katzuhiko Ito, and Hiroshi Yamazaki
- Organizer
 23^<rd> JSSX Annual Meeting
- Place of Presentation
 熊本
- Data Source
 KAKENHI-PROJECT-19591819
[Presentation] Genetic Polymorphism of the Flavin-Containing Monooxygenase 3(FMO3) Associatedwith Trimethylaminuria in a Japanese Cohort2007
- Author(s)
  Makiko Shimizu, Satomi Nagashima, Norie Murayama and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Oxygenation Activities of the Flavin-Containing Monooxygenase 3(FMO3) Variants Found in Japanese2007
- Author(s)
  Satomi Nagashima, Makiko Shimizu, Hiroshi Yano, Norie Murayama, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Metabolic pathway of anesthesic drug propofol in human liver microsomes2007
- Author(s)
  Node, Murayama, Masaki, Minoshima, Naoko, Imai, Makiko, Shimizu, Hiroshi, Yamazaki
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] 薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらすアミン化合物酸化的代謝の個人差に関する臨床薬理学研究2007
- Author(s)
  山崎浩史, 清水万紀子, 永島里美, 村山典恵
- Organizer
  第28回日本臨床薬理学会年会
- Place of Presentation
  栃木
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Voriconazole methyl hydroxylation and N-oxidation catalyzed by CYP3A4 and CYP2C19 in human liver microsomes2007
- Author(s)
  Hiroshi Yamazaki, Norie Murayama, Naoko Imai, Takahisa Nakane, Makiko Shimizu
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Inhibitory effects of epigallocatechin-3 gallate on the exocytosis in adrenal chromaffin cells2007
- Author(s)
  Norie Murayama
- Organizer
  49回日本神経化学会大会
- Place of Presentation
  名古屋
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] Genetic polymorphism of the flavin-containing monooxygenase 3(FMO3) associated with trimethylaminuria in a Japanese Cohort2007
- Author(s)
  Makiko, Shimizu, Satomi, Nagashima, Node, Murayama, Hiroshi, Yamazaki
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] 全身性プロポフォールの覚醒遅延に関するヒト肝薬物代謝酵素の検討2007
- Author(s)
  村山典恵、簑島正樹、今井直子、清水万紀子、山崎浩史
- Organizer
  第127会日本薬学年会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Voriconazole methyl hydroxylation and N-oxidation catalyzed by CYP3A4 and CYP2C19 in human liver microsomes2007
- Author(s)
  Hiroshi Yamazaki, Norie Murayama, Naoko Imai, Takahisa Nakane, Makiko Shimizu
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Omega- and 4-Hydroxylation of the Anesthetic Agent Propofol Catalyzed by Human Liver Microsomal Cytochrome P450 2B62007
- Author(s)
  Norie Murayama , Masaki Minoshima, Makiko Shimizu, F.Peter Guengerich, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Guengerich, and Hiroshi Yamazaki Omega- and 4-Hydroxylation of the Anesthetic Agent Propofol Catalyzed by Human Liver Microsomal Cytochrome P450 2B62007
- Author(s)
  Node, Murayama, Masaki, Minoshima, Makiko, Shimizu, F., Peter
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Omega-and 4-Hydroxylation of the Anesthetic Agent Propofol Catalyzed by Human Liver Microsomal Cytochrome P450 2B62007
- Author(s)
  Norie Murayama, Masaki Minoshima, Makiko Shimizu, F.Peter Guengerich, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Omega- and 4-Hydroxylation of theAnesthetic Agent Propofol Catalyzed by HumanLiver Microsomal Cytochrome P450 2B62007
- Author(s)
  Norie Murayama, Masaki Minoshima, Makiko Shimizu, F.Peter Guengerich, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Omega- and 4-Hydroxylation of the Anesthetic Agent Propofol Catalyzed by Human Liver Microsomal Cytochrome P450 2B62007
- Author(s)
  Norie Murayama, Masaki Minoshima, Makiko Shimizu, F.Peter Guengerich, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Genetic Polymorphism of the Flavin-Containing Monooxygenase 3(FMO3)Associated with Trimethylaminuria in a Japanese Cohort2007
- Author(s)
  Makiko Shimizu, Satomi Nagashima, Norie Murayama and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Characterization of exocytotic events in ventral midbrain dopaminergic neurons2006
- Author(s)
  Konosuke, Kumakura, Satoshi, Yamada, Mizuki, Sekiguchi, Norie, Murayama, Nobuyuki, Sasakawa
- Organizer
  The 49th Annual Meeting of The Japanese Society for Neurochemistry
- Place of Presentation
  Nagoya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] Trafficking for exocytosis ; Imaging studies in the chromaffin cell2006
- Author(s)
  K., Kumakura, N., Sasakawa, N., Murayama, M., Murakami, A., Riva
- Organizer
  13th International Symposium on Chromaffin Cell Biology
- Place of Presentation
  Pucon, Chile
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] Inhibitory effects of epigallocatechin-3 gallate on the exocytosis in adrenal chromaffin cells2006
- Author(s)
  Norie, Murayama, Atuko, Otuka, Mitunori, Hayashi, Nobuyuki, Sasakawa, Konosuke, Kumakura
- Organizer
  The 49th Annual Meeting of The Japanese Society for Neurochemistry
- Place of Presentation
  Nagoya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] Effects of epigallocatechin-3 gallate, a green tea catechin, on the regulatory mechanisms of exocytosis in adrenal chromaffin cells. J2006
- Author(s)
  Norie, Murayama, Atuko, Otuka, Nobuyuki, Sasakawa, Konosuke, Kumakura
- Organizer
  The 79th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] Effects of epigallocatechin-3 gallate,a green tea catechin,on the regulatory mechanisms of exocytosis in adrenal chromaffin cells2006
- Author(s)
  Norie Murayama
- Organizer
  第79回日本薬理学会年会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] Rat Cytochrome P450 2C11 Involved in Oxidation of Anesthetic Drug Propofol and Deactivated by Propofol in Liver Microsomes2006
- Author(s)
  Hiroshi, Yamazaki, Makiko, Shimizu, Takashi, Nagashima, Masaki, Minoshima, Node, Murayama
- Organizer
  21st JSSX meeting
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Amperometric detection and characterization of exocytotic events in single ventral midbrain dopaminergic neurons2006
- Author(s)
  Satoshi, Yamada, Mizuki, Sekiguchi, Norie, Murayama, Nobuyuki, Sasakawa, Konosuke, Kumakura
- Organizer
  The 79th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] Characterization of a single exoxcytotic event in digitonin-permeabilized adrenal chromaffin cells2005
- Author(s)
  Nobuyuki, Sasakawa, Norie, Murayama, Konosuke, Kumakura
- Organizer
  The 78th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] A single exoxcytotic event in digitonin-permeabilized adrenal chromaffin cells2005
- Author(s)
  Nobuyuki, Sasakawa, Norie, Murayama, Konosuke, Kumakura
- Organizer
  The 48th Annual Meeting of The Japanese Society for Neurochemistry
- Place of Presentation
  Fukuoka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] (2003)Amperometric detection and characterization of exocytosis from single PC12h cells2004
- Author(s)
  Nobuyuki, Sasakawa, Norie, Murayama, Konosuke, Kumakura
- Organizer
  The 46th Annual Meeting of The Japanese Society for Neurochemistry
- Place of Presentation
  Niigata
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] Tempo-spatial regulation of the vesicle dynamics by PKC in adrenal chromaffin cells2004
- Author(s)
  Konosuke, Kumakura, Nobuyuki, Sasakawa, Norie, Murayama
- Organizer
  The 47th Annual Meeting of The Japanese Society for Neurochemistry
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] A high efficient transfecdtion method for chromaffin cells2004
- Author(s)
  Norie, Murayama, Nobuyuki, Sasakawa, Natsue, Yoshimura, Konosuke, Kumakura
- Organizer
  The 46th Annual Meeting of The Japanese Society for Neurochemistry
- Place of Presentation
  Niigata
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] Characteristic regulation of exocytotic eventsnby PKC isoforms in single adrenal chromaffin cells2004
- Author(s)
  Nobuyuki, Sasakawa, Norie, Murayama, Konosuke, Kumakura
- Organizer
  The 77th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] Tempo-spatial regulation of exocytotic events by protein kinase C in adrenal chromaffin cells2004
- Author(s)
  K., Kumakura, N., Saakawa, S., Hosaka, M., Hayashi, N., Murayama
- Organizer
  The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry
- Place of Presentation
  Hong Kong
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] Regulation of exocytotic events by protein kinase C isoform in single adrenal chromaffin cells2004
- Author(s)
  Nobuyuki, Sasakawa, Norie, Murayama, Konosuke, Kumakura
- Organizer
  The 47th Annual Meeting of The Japanese Society for Neurochemistry
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] Kumakura(2003)Effects of Shiga Toxin on Exocytotic Event in Single Adrenal Chromaffin Cells2004
- Author(s)
  Nobuyuki, Sasakawa, Kiyotaka, Nishikawa, Norie, Murayama, Yumiko, Satoh, Yasuhiro Natori, Konosuke
- Organizer
  The 76th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  Fukuoka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] A high efficient transfecdtion method for chromaffin cells2003
- Author(s)
  Norie Murayama
- Organizer
  第46回日本神経化学会大会
- Place of Presentation
  新潟
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15200030
[Presentation] レボカルニチン投与時の透析患者におけるトリメチルアミンおよびN-酸化体の体内動態の検討
- Author(s)
  小泉綾乃、清水万紀子、若林あかり、村山典恵、小篠榮、山崎浩史
- Organizer
  第66回聖マリアンナ医科大学医学会学術集会
- Place of Presentation
  聖マリアンナ医科大学　(神奈川県川崎市)
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] 抗精神病薬オランザピン投与日本人患者における血漿中薬物濃度の個人差
- Author(s)
  大久保真穂、成田桃子、村山典恵、森田翔子、中村浩也、清水万紀子、秋元洋一、後藤晶子、○山崎浩史
- Organizer
  日本薬学会第135 回年会
- Place of Presentation
  神戸学院大学,兵庫医療大学(神戸市）
- Year and Date
  2015-03-25 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] 抗精神病薬リスペリドン投与日本人患者における血漿中薬物濃度の個人差
- Author(s)
  ○大久保真穂1、村山典恵1、森田翔子1、森亜沙美1、倉林優貴1、秋元洋一2、後藤晶子2、山崎浩史
- Organizer
  日本薬学会第135 回年会
- Place of Presentation
  神戸学院大学,兵庫医療大学(神戸市）
- Year and Date
  2015-03-25 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] ヒトフラビン含有酸素添加酵素3が関与する薬物相互作用
- Author(s)
  清水万紀子、佐藤歩、石井有紀、白石有紗、村山典恵、山崎浩史
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館　(熊本県)
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] Effects of CYP2D6 and CYP3A5 genotypes and co-administrated drugs on the metabolic clearance of antidepressant mirtazapine
- Author(s)
  ○Maho Okubo, Norie Murayama, Jun Miura, Yasuji Chiba and Hiroshi Yamazaki
- Organizer
  19th North American ISSX Meeting / 29th JSSX Meeting
- Place of Presentation
  Hilton San Francisco, San Francisco, California, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] Roles of Auto-Induction of Human P450 3A Enzymes Involved in The Teratogenicity of Thalidomide
- Author(s)
  ○Norie Murayama, Hiroshi Suemizu , Christophe Chesné, Norio Shibata,F. Peter Guengerich, Hiroshi Yamazaki
- Organizer
  19th North American ISSX Meeting / 29th JSSX Meeting
- Place of Presentation
  Hilton San Francisco, San Francisco, California, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] サリドマイドによるヒトP450酵素自己誘導機構の要因
- Author(s)
  ○村山典恵、矢島加奈子、柴田哲男、鵜藤雅裕、山崎浩史
- Organizer
  日本薬学会第135 回年会
- Place of Presentation
  神戸学院大学、兵庫医療大学(神戸市）
- Year and Date
  2015-03-25 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24590211

1. YAMAZAKI Hiroshi (30191274)

# of Collaborated Projects: 16 results

# of Collaborated Products: 168 results
2. SHIMIZU Makiko (90307075)

# of Collaborated Projects: 16 results

# of Collaborated Products: 98 results
3. YAMAZOE Yasushi (00112699)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KATO Ryuichi (40112685)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAGATA Miki (10196488)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NAGATA Kiyoshi (80189133)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KUMAKURA Konosuke (70129790)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
8. SASAKAWA Nobuyuki (20187107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
9. 岩野俊介 (80374560)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 宇野泰広 (90372276)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. 鎌滝哲也 (00009177)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. YAZUMORI Toshio (70182350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 青山隆彦 (70384633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MIYADO Shinji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 甲斐文夫

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 竹中重雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 上原正太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 生城真一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 西川美宇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 扇屋大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 神矢佑輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 山折大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Murayama Norie 村山 典惠

MURAYAMA Norie 村山 典惠

村山 典恵 ムラヤマ ノリエ

村山 典惠 ムラヤマ ノリエ

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Prediction system of risk assessments by change the drug metabolism activity in placenta for pregnancyPrincipal Investigator

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Prediction system of risk assessments by change the drug metabolism activity in placenta for pregnancyPrincipal Investigator

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The most suitable administration of antidepressive drug to avoid risk of side effects in patientPrincipal Investigator

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Drug interaction of thalidomide with midazolam and other compounds : heterotropic cooperativiy of human cyochrome P450Principal Investigator

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Polymorphic drug-metabolizing enzymes of anesthetics agent propofol rekated to its infusion syndrome.Principal Investigator

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Murayama Norie 村山典惠

MURAYAMA Norie 村山典惠

村山典恵ムラヤマノリエ

村山典惠ムラヤマノリエ