Saijo Masafumi 西條将文

… Alternative Names

SAIJO Masafumi 西條将文

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Researcher Number	90221986
Other IDs
External Links
Affiliation (Current)	2025: 大阪大学, 大学院生命機能研究科, 准教授
Affiliation (based on the past Project Information) *help	2022: 大阪大学, 大学院生命機能研究科, 准教授 2020 – 2021: 大阪大学, 生命機能研究科, 准教授 2015 – 2017: 大阪大学, 生命機能研究科, 准教授 2014: 大阪大学, 大学院生命機能研究科, 准教授 2009: 大阪大学, 大学院・生命機能研究科, 准教授 … More 2007: 大阪大学, 大学院・生命機能研究科, 准教授 2006: 大阪大学, 大学院生命機能研究科, 助教授 2003 – 2005: 大阪大学, 大学院・生命機能研究科, 助教授 2002: 助教授 2001: Institute for Molecular and Cellular Biology, Osaka University, Division of Cellular Genetics, Associate Professor, 細胞生体工学センター, 助教授 1994 – 2000: 大阪大学, 細胞生体工学センター, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / Risk sciences of radiation and chemicals / Molecular biology Except Principal Investigator Human genetics / Functional biochemistry / Human genetics / Biological Sciences
Keywords	Principal Investigator ヌクレオチド除去修復 / XPA / 色素性乾皮症 / RPA / 蛋白質間相互作用 / 皮膚癌 / two-hybrid system / ERCC1 / 紫外線 / 紫外線高感受性症候群 … More / コケイン症候群 / dermo-1 / RLGS / UVSSA / CSB / CSA / ゲノム / DNA修復 / UV / SUMO化 / ユビキチン化 / 遺伝子欠損マウス / TFIIH / GTP結合モチーフ / two-hydrid system / プラスミド・シャッフリング / DNA結合 / DNA除去修復 … More Except Principal Investigator 色素性乾皮症 / DNA修復 / 遺伝子ターゲティング / 転写 / ノックアウトマウス / コケイン症候群 / xeroderma pigmentosum / DNA repair / Cockayne syndrome / gene targeting / 紫外線 / 転写と共役した修復 / ヌクレオチド除去修復 / transcription / RPA / Znフィンガー / 核移行 / GTPase / ミスマッチ修復 / アポトーシス / 小脳発育 / 蛋白質複合体 / RNAポリメラーゼII / スプライシング / 微小核融合法 / cerebellum / neurodysfunction / UV-irradiation / nuclear matrix / 紫外線皮膚発癌 / skin cancer / ultraviolet light / microinjection / NMR / 皮膚癌 / 基本転写 / 遺伝子ターゲッティング / RLGS / 皮膚発癌 / 遺伝疾患 / photoreactivation / ultraviolet / Yeast homolog / knockout mice / two hybrid system / エンドヌクレアーゼ / DNA結合能 / 2ハイブリドシステム / 酵母ホモログ / αハイブリドシステム / p53 gene / carcinogenesis / knock-out mouse / Zn-finger / DNA binding / DNA結合ドメイン / p53遺伝子 / 発がん / DNA結合 / 遺伝子発現 / 転写伸長 / 遺伝子発現制御 / 遺伝情報発現 / 微小核融合 / 酸化的DNA損傷 / UV^s症候群 / TFIIS / ホルモンレセプター / CAK / TFIIH / XPG / ユビキチン・リガーゼ / 色素性幹皮症 / ホルモン受容体 / ユビキチン化 / CGH array / XPD / ユビキチンリガーゼ / 小脳失調 / 核マトリクス / ダブルノックアウトマウス / WD40リピート / ユビキチン / DNA損傷 / siRNA / ユビキンチンリガーゼ / 紫外線高感受性症候群 Less

Functional analysis of Cockayne syndrome proteins in transcription-coupled nucleotide excision repairPrincipal Investigator
- Principal Investigator
  
  Saijo Masafumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Osaka University
Elucidation of molecular mechanism of transcription-coupled nucleotide excision repairPrincipal Investigator
- Principal Investigator
  
  SAIJO Masafumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Osaka University
Analyses of nucleotide excision repair factors in the regulation of gene expression
- Principal Investigator
  
  NARITA Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
Molecular genetic analysis of cellular response to transcription-blocking DNA damage and its defective disorders
- Principal Investigator
  
  TANAKA Kiyoji
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Human genetics
- Research Institution
  Osaka University
転写とヌクレオチド除去修復機構を共役する新規蛋白質複合体の解析
- Principal Investigator
  
  TANAKA Kiyoji
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
DNA修復におけるXPAの機能と紫外線誘発皮膚発癌に伴う遺伝子変化の解析Principal Investigator
- Principal Investigator
  
  西條将文
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
Molecular genetics of human diseases with defect in transcription and DNA repair
- Principal Investigator
  
  TANAKA Kiyoji
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human genetics
- Research Institution
  Osaka University
DNA修復におけるXPA蛋白質の機能とその欠損による紫外線誘発皮膚発癌の解析Principal Investigator
- Principal Investigator
  
  西條将文
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
DNA除去修復におけるXPA蛋白質の機能解析Principal Investigator
- Principal Investigator
  
  西條将文
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
ヌクレオチド除去修復におけるXPA蛋白質の機能解析Principal Investigator
- Principal Investigator
  
  西條将文
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
新規XPA結合蛋白質の解析Principal Investigator
- Principal Investigator
  
  西條将文
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Osaka University
Molecular biology of nucleotide excision repair-deficient diseases
- Principal Investigator
  
  TANAK Kiyoji
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human genetics
- Research Institution
  Osaka University
DNA除去修復におけるXPA蛋白質の機能解析Principal Investigator
- Principal Investigator
  
  西條将文
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Molecular Dissection of Human DNA Excision Repair Genes
- Principal Investigator
  
  TANAKA Kiyoji
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Osaka University
DNA除去修復における色素性乾皮症蛋白の相互作用の解析Principal Investigator
- Principal Investigator
  
  西條将文
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Analysis of DNA repair functions of xeroderma pigmentosum gene
- Principal Investigator
  
  TANAKA Kiyoji
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Human genetics
- Research Institution
  Osaka University

All 2022 2018 2017 2016 2015 2010 2009 2008 2007 2004 Other

All Journal Article Presentation

[Journal Article] Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair2022
- Author(s)
  Sakasai Ryo、Wakasugi Mitsuo、Matsui Tadashi、Sunatani Yumi、Saijo Masafumi、Matsunaga Tsukasa、Iwabuchi Kuniyoshi
- Journal Title
  
  DNA Repair
  
  Volume: 113 Pages: 103318-103318
- DOI
  10.1016/j.dnarep.2022.103318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K12319, KAKENHI-PROJECT-19H04265, KAKENHI-PROJECT-20K06543, KAKENHI-PROJECT-21K12245
[Journal Article] Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP72018
- Author(s)
  Higa Mitsuru、Tanaka Kiyoji、Saijo Masafumi
- Journal Title
  
  The FEBS Journal
  
  Volume: 285 Issue: 5 Pages: 965-976
- DOI
  10.1111/febs.14382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02820
[Journal Article] Generation of splice switching oligonucleotides targeting the Cockayne syndrome group B gene product in order to change the diseased cell state.2018
- Author(s)
  Sin Yoosil、Makimura Futaba、 Saijo Masafumi、Obika Satoshi
- Journal Title
  
  Biochemical and Biophysicai Research Communications
  
  Volume: ー
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02820
[Journal Article] DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing.2017
- Author(s)
  Philamer C. Calses, Kiranjit K. Dhillon, Nyka Tucker, Yong Chi, Jen-wei Huang, Masaoki Kawasumi, Paul Nghiem, Yemin Wang, Bruce E. Clurman, Celine Jacquemont, Philip R. Gafken, Kaoru Sugasawa, Masafumi Saijo, Toshiyasu Taniguchi
- Journal Title
  
  Cell Reports
  
  Volume: 19 Issue: 1 Pages: 162-174
- DOI
  10.1016/j.celrep.2017.03.021
- NAID
  120006360182
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02820, KAKENHI-PUBLICLY-16H01311, KAKENHI-PROJECT-16H06307
[Journal Article] The C-terminal Region and SUMOylation of Cockayne Syndrome Group B Protein Play Critical Roles in Transcription-coupled Nucleotide Excision Repair.2016
- Author(s)
  Yooksil Sin,Kiyoji Tanaka, Masafumi Saijo
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Issue: 3 Pages: 1387-1397
- DOI
  10.1074/jbc.m115.683235
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02820
[Journal Article] Stabilization of Ultraviolet (UV)-stimulated Scaffold Protein A by Interaction with Ubiquitin-specific Peptidase 7 Is Essential for Transcription-coupled Nucleotide Excision Repair.2016
- Author(s)
  Mitsuru Higa, Xue Zhang, Kiyoji Tanaka, Masafumi Saijo
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Issue: 26 Pages: 13771-13779
- DOI
  10.1074/jbc.m116.724658
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02820
[Journal Article] Regulation of Transcription Elongation by the XPG-TFIIH Complex Is Implicated in Cockayne Syndrome.2015
- Author(s)
  Takashi Narita, Keiko Narita, Arato Takedachi, Masafumi Saijo, Kiyoji Tanaka
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 35 Issue: 18 Pages: 3178-3188
- DOI
  10.1128/mcb.01401-14
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02820
[Journal Article] The DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku, and contributes to the recruitment of XPA.2010
- Author(s)
  Arato Takedachi, Masafumi Saijo, Kiyoji Tanaka
- Journal Title
  
  Molecular and Cellular Biology 30
  
  Pages: 2708-2723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109006
[Journal Article] Isolation of XAB2 complex involved in pre-mRNA splicing, transcription and transcription-coupled repair.2008
- Author(s)
  Isao Kuraoka, Shinsuke Ito, Tadashi Wada, Mika Hayashida, Lily Lee, Masafumi Saijo, Yoshimichi Nakatsu, Megumi Matsumoto, Tsukasa Matsunaga, Hiroshi Handa, Jun Qin, Yoshihiro Nakatani, Kiyoji Tanaka.
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 940-950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109006
[Journal Article] Functional TFIIH is required for UV-induced translocation of CSA to nuclear matrix.2007
- Author(s)
  Masafumi Saijo, et. al.
- Journal Title
  
  Molecular and Cellular Biology 27
  
  Pages: 2538-2547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109006
[Journal Article] Functional TFIIH is required for UV-induced translocation of CSA to nuclear matrix.2007
- Author(s)
  Masafumi Saijo
- Journal Title
  
  Molecular and Cellular Biology (印刷中)
- Data Source
  KAKENHI-PROJECT-17109006
[Journal Article] Functional TFIIH is required for UV-induced translocation of CSA to nuclear matrix.2007
- Author(s)
  Masafumi Saijo, Tamami Hirai, Akiko Ogawa, Aki Kobayashi, Shinya Kamiuchui, Kiyoji Tanaka
- Journal Title
  
  Molecular and Cellular Biology 27
  
  Pages: 2538-2547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109006
[Journal Article] Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1 and TFIIH.2004
- Author(s)
  Masafumi Saijo., Toshiro Matsuda., Isao Kuraoka, Kiyoii Tanaka.
- Journal Title
  
  Biochemical and Biophysical Research Communications 321
  
  Pages: 815-822
- Data Source
  KAKENHI-PROJECT-12143203
[Journal Article] UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.
- Author(s)
  Kaoru Sugasawa, Yuki Okuda, Masafumi Saijo, Ryotaro Nishi, Noriyuki Matsuda, Gilbert Chu, Toshio Mori, Shigenori Iwai, Keiji Tanaka, Kiyoji Tanaka, Fumio Hanaoka.
- Journal Title
  
  Cell (in press.)
- Data Source
  KAKENHI-PROJECT-12143203
[Presentation] 転写を阻害するDNA損傷を除去する仕組み：転写と共役したヌクレオチド除去修復に関与する因子の機能解析2018
- Author(s)
  西條将文
- Organizer
  第６回　バイオシグナル研究会（神戸大学）
- Data Source
  KAKENHI-PROJECT-15H02820
[Presentation] UVSSAユビキチン化の阻害はUSP7からの解離で引き起こされた転写と共役したヌクレオチド除去修復の欠損を抑制する2017
- Author(s)
  比嘉光、田中亀代次、西條将文
- Organizer
  第40回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15H02820
[Presentation] USP7との結合によるUVSSAの安定性は転写と共役したヌクレオチド除去修復において必須である2016
- Author(s)
  比嘉光、Zhang Xue、田中亀代次、西條将文
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H02820
[Presentation] 紫外線DNA損傷とSUMO-Ubi系、そして病態2016
- Author(s)
  西條　将文
- Organizer
  第13回SUMO研究会
- Place of Presentation
  関西学院大学大阪梅田キャンパス（大阪府大阪市）
- Year and Date
  2016-01-22
- Data Source
  KAKENHI-PROJECT-15H02820
[Presentation] 転写と共役した修復におけるCSBタンパク質の機能にはC末端領域とSUMO化が必要である2015
- Author(s)
  申　育實、田中　亀代次、西條　将文
- Organizer
  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H02820
[Presentation] Novel function of nucleotide excision repair factor and its relevance to xeroderma pigmentosum and Cockayne syndrome.2009
- Author(s)
  Kiyoji Tanaka, Shinsuke Ito, Katsuyoshi Horibata, Takashi Narita, Masafumi Saijo
- Organizer
  10th International Conference on Environmental Mutagens
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-17109006

1. TANAKA Kiyoji (80144450)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
2. NAKATSU Yoshimichi (00207820)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. TAKEUCHI Seiji (10304065)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KURAOKA Isao (60335396)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. NARITA Takashi (50437399)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. HORIBATA Katsuyoshi (40402995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. OHKUMA Yoshiaki (70192515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YASUI Akira (60191110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HANAOKA Fumio (50012670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 吉野雅文 (00346149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. WOOD Richard D

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HOEIJMAKERS ヤン

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HOEIJMAKERS Jan H.J

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HOEIJMAKERS ヤンエイチジェイ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HOEIJMARKERS ジェイ.エイチ.ジ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 若杉光生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 松永司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saijo Masafumi 西條 将文

SAIJO Masafumi 西條 将文

Research Projects

Research Products

Co-Researchers

Functional analysis of Cockayne syndrome proteins in transcription-coupled nucleotide excision repairPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanism of transcription-coupled nucleotide excision repairPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of nucleotide excision repair factors in the regulation of gene expression

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular genetic analysis of cellular response to transcription-blocking DNA damage and its defective disorders

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

転写とヌクレオチド除去修復機構を共役する新規蛋白質複合体の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DNA修復におけるXPAの機能と紫外線誘発皮膚発癌に伴う遺伝子変化の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Molecular genetics of human diseases with defect in transcription and DNA repair

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNA修復におけるXPA蛋白質の機能とその欠損による紫外線誘発皮膚発癌の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

DNA除去修復におけるXPA蛋白質の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ヌクレオチド除去修復におけるXPA蛋白質の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

新規XPA結合蛋白質の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular biology of nucleotide excision repair-deficient diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNA除去修復におけるXPA蛋白質の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Molecular Dissection of Human DNA Excision Repair Genes

Principal Investigator

Saijo Masafumi 西條将文

SAIJO Masafumi 西條将文