KOZAWA Osamu 小澤修

Researcher Number	90225417
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2016 – 2023: 岐阜大学, 大学院医学系研究科, 教授 2011 – 2015: 岐阜大学, 医学(系)研究科(研究院), 教授 2014: 岐阜大学, 大学院医学研究科, 教授 2013: 岐阜大学, 医学系研究科, 教授 2013: 岐阜大学, 大学院医学系研究科, 教授 … More 2012: 岐阜大学, 大学院・医学系研究科, 教授 2010 – 2011: 岐阜大学, 医学系研究科, 教授 2007 – 2010: Gifu University, 大学院・医学系研究科, 教授 2006: Gifu University, graduate School of Medicine, Professor, 大学院医学系研究科, 教授 2005: Gifu University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 2004 – 2005: Gifu Univ., School of Med.Pharmacol., Prof., 大学院・医学研究科, 教授 2002 – 2003: Gifu University, School of Medicine, Professor, 医学部, 教授 1997 – 2001: 岐阜大学, 医学部, 助教授 1999: School of Medicine, Gifu University, Associate Professor, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Metabolomics / Circulatory organs internal medicine / 内分泌・代謝学 Except Principal Investigator Orthopaedic surgery / Anesthesiology/Resuscitation studies / General pharmacology / Anesthesiology / Basic Section 56020:Orthopedics-related / Basic Section 53010:Gastroenterology-related … More / Basic Section 55050:Anesthesiology-related / General pharmacology / 応用薬理学・医療系薬学 / Gastroenterology / Laboratory medicine Less
Keywords	Principal Investigator ストレス蛋白質 / 肝細胞がん / 骨芽細胞 / fibrinolytic system / α2-antiplasmin / vascular endothelial growth factor / 線溶系因子 / heat shock protein / 転移 / 肝細胞癌 … More / HSP20 / 低分子量 / 増殖 / 細胞増殖 / マップキナーゼ / HSP27 / YAP / 細胞運動 / HSP22 / ストレスタンパク質 / knock out mouse / bone metabolism / osteoclasts / osteoblasts / 遺伝子欠損マウス / 骨代謝 / 破骨細胞 / acute coronary syndrome / 肺性心 / 急性冠症候群 / aggregation / vascular smooth muscle / platelet / 凝集 / 粘着 / 血管平滑筋 / 血小板 / sphingosine 1-phosphate / endothelin / prostaglandin / mitogen-activated protein kinase / protein kinase C / osteoblast / スフィンゴシン-1-リン酸 / エンドセリン / プロスタグランジン / プロテインキナーゼC / PI3キナーゼ / Ｂａｘ / アポトーシス / ＨＳＰ20 / JNK / 浸潤 / リン酸化 / Bax / ホスファチジルイノシトール3-キナーゼ / ストレス蛋白 / 低分子量ストレス蛋白質 / 肝がん細胞 / 肝臓学 / ポリフェノール / カテキン … More Except Principal Investigator 骨芽細胞 / 血小板 / VEGF / HSP27 / 血栓 / 線溶系 / 骨代謝 / サイトカイン / ストレス蛋白質 / 破骨細胞 / ノックアウトマウス / 骨粗鬆症 / 細胞内情報伝達 / 中枢神経保護 / osteoprotegerin / ストレスタンパク質 / 細胞運動 / TGF-β / heat shock protein / osteoblast / プラスミン / 線溶系因子 / MAPキナーゼ / FGF-2 / リン酸化 / 心血管 / GDNF / アストロサイト / Heat shock protein / ストレス / アポトーシス / 神経細胞死 / 網膜 / 細胞移動 / ケモカイン / TNF-α M-CSF / M-CSF / bFGF / oncostatin M / 骨マクロファージ / 肝癌 / 肝細胞癌 / 低分子量 / 鎮痛薬 / 骨リモデリング / 慢性疼痛 / 骨粗鬆症性 / 骨代謝調節因子 / RANKL / リモデリング / 骨粗鬆性腰痛 / 石灰化 / IGF-I / HSP70 / 遊走細胞 / MAP キナーゼ / PDGF / HSP90 / 細胞遊走 / 細胞増殖因子 / 熱ショックタンパク質 / 高分子量 / migration / PDGF-BB / HSP22 / molecular chaperone / crstallin / ischemia / cardiac myocytes / 凝固・線溶系 / 分子シャペロン / クリスタリン / 虚血 / 心筋 / ovariectomy / gene knockout mice / bone metabolism / fibrinolytic factor / osteoclast / 遺伝子ノックアウトマウス / 骨髄 / 卵巣除去手術 / Thrombosis / Ischemia / Regenerative medicine / Endothelial cell / Atherosclerosis / Plamsin / Remodeling / alpha2-antiplasmin / Plasmin / 血栓症 / 虚血疾患 / 再生医療 / 内皮細胞 / 動脈硬化 / Pulmonary embolism / Fibrinolysis / Deficient mice / α2-antiplasmin / Venous thrombosis / 線溶系阻害因子 / 肺塞栓 / アルファ2アンチプラスミン / 静脈血栓 / TUNEL method / retina / NMDA / apoptosis / transient ischemia / excitotoxin / neural damage / plasminogen activator / 遺伝子制御 / 海馬 / 興奮性アミノ酸 / 虚血-再灌流 / 神経障害 / Furosin / Glycated protein / Furancarboxylic acid / Flecainide / Ofloxacin / Hair Analysis / Drug use / Drug hazard / 母集団薬物動態 / ブプレノルフィン / コデイン / モルヒネ / フルクトースリジン / 疾病経過 / 薬害予防 / フロシン / 糖化蛋白質 / フランカルボン酸 / フレカイニド / オフロキサシン / 毛髪分析 / 服薬歴 / 薬害 / soluble CD40 ligand / Rac / thromboxane A2 / p44/p42 MAP kinase / 活性化第X因子 / p38 MAP kinase / スフィンゴシン1リン酸 / コラーゲン / 凝固系 / CD40 ligand / 可溶型 / PDGF-AB / 凝固因子 / グリア細胞 / interleukin-6 / interleukin-1β / STAT3 / cAMP / IL-6 / IL-1β / prostaglandin E2 / SAPK/JNK / p44/p42 MAPキナーゼ / オステオプレテジェリン / プロスタグランジンD2 / オステオプロテジェリン / プロスタグランジン / AMPキナーゼ / エネルギー代謝 / Osteocalcin / Osteoprotegerin / ＨＳＰ27 / 翻訳 / eIF4E / オステオカルシン / 凝固障害 / PAI-1 / アンチトロンビン / 全身性炎症反応症候群 / 侵害刺激 / ＰＡＩ-1 / トロンボポエチン / トロンボモジュリン / トロンビン / 線溶 / 綿溶 / 凝固 / ベンゾジアゼピン / PI3-kinase/Akt経路 / デクスメデトミジン / 全身麻酔薬 / EUS-FNA / Gemcitabine / 膵癌 / ストレス応答 / 糖尿病 / 視力障害 / 動脈血栓 / TUNEL染色 / DNA断片化 / 虚血-再潅流 Less

骨マクロファージと骨芽細胞の相互作用による骨代謝制御機構の分子基盤に関する研究
- Principal Investigator
  
  徳田治彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Center for Geriatrics and Gerontology
Identification of molecular target protein of small heat shock proteins and analysis of their functional regulatory system
- Principal Investigator
  
  Nishiwaki Rie
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Gifu University
Elucidation of the effect of analgesics on bone remodeling for osteoporotic pain and its molecular mechanism
- Principal Investigator
  
  Iida Hiroki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Gifu University
Roles of high molecular-weight heat shock proteins in bome metabolism, especially osteoblast functions
- Principal Investigator
  
  Tokuda Haruhiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Gifu University
Heat shock protein 22 (HSPB8) reduces the migration of hepatocellular carcinoma cells through the suppression of the phosphoinositide 3-kinase (PI3K)/AKT pathwayPrincipal Investigator
- Principal Investigator
  
  Kozawa Osamu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
The molecular target of heat shock protein in bone metabolism
- Principal Investigator
  
  Otsuka Takanobu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya City University
Roles of AMP-activated protein kinase in bone metabolism
- Principal Investigator
  
  TOKUDA HARUHIKO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Gifu University
neuroprotection by the maintenance of blood brain barrier
- Principal Investigator
  
  Tanabe Kumiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Gifu University
Cross-talk regulation by platelets, coagulation system and fibrinolysis system in response to sepsis
- Principal Investigator
  
  akamatsu shigeru
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Gifu University
Molecular targets of low-molecular-weight heat shock proteins in hepatocellular carcinoma cell proliferationPrincipal Investigator
- Principal Investigator
  
  KOZAWA Osamu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Role of low-molecular-weight heat shock protein and the molecular mechanism in bone metabolism
- Principal Investigator
  
  FUKUOKA Muneyoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya City University
The role of HSP27 in the anti-tumor action of gemcitabine for pancreatic cancer
- Principal Investigator
  
  YASUDA Ichiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Intracellular signaling of neuroprotection by general anesthetics
- Principal Investigator
  
  TANABE Kumiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Gifu University
Molecular mechanism of responses to stress in blood coagulation and fibrinolysis system
- Principal Investigator
  
  AKAMATSU Shigeru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Gifu University
Role of low-molecular-weight heat shock proteins and the molecular mechanism in hepatocellular carcinoma cell proliferationPrincipal Investigator
- Principal Investigator
  
  KOZAWA Osamu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Molecular mechanism of platelet hyper-aggregation in patients with type 2 diabetes and development of method for the diagnosis
- Principal Investigator
  
  TOKUDA Haruhiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Gifu University
Molecular mechanisms of neuroprotection in astrocytes
- Principal Investigator
  
  TANABE Kumiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Gifu University
Molecular mechanism of responses to stress in cardiovascular system
- Principal Investigator
  
  AKAMATSU Shigeru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Gifu University
Molecular mechanism of chaperone properties in bone metabolismPrincipal Investigator
- Principal Investigator
  
  KOZAWA Osamu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Gifu University
Investigation of the role of the fibrinolytic system in cardiac remodeling and its clinical relevance
- Principal Investigator
  
  AKAMATSU Shigeru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Gifu University
Investigation of the role of the fibrinolytic system in bone metabolismPrincipal Investigator
- Principal Investigator
  
  KOZAWA Osamu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Gifu University
Elucidation of roles of fibrinolytic system in bone turnover in vivo.
- Principal Investigator
  
  ISHISAKI Akira
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hokkaido University
  Gifu University
Identficatbn of roles and significance between plasmin and VEGF on regenerative medicine
- Principal Investigator
  
  MATSUNO Hiroyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Gifu University
Investigation of the role of the fibrinolytic system in isehemic diseasesPrincipal Investigator
- Principal Investigator
  
  KOZAWA Osamu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gifu University
ROLE OF ENDOGENOUS TISSUE TYPE PLASMINOGEN ACTIVATOR IN NEURONAL DAMAGES
- Principal Investigator
  
  NIWA Masayuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  GIFU UNIVERSITY
Investigation of pulmonary thromboembolism due to venous thrombus : pharmacological approach for development of new therapeutic drags.
- Principal Investigator
  
  MATSUNO Hiroyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Gifu University
網膜中心動脈の血栓性閉塞・溶解による新たな虚血再潅流モデルと薬理的神経細胞死制御
- Principal Investigator
  
  UEMATSU Tohihiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Gifu University
Investigation of p20, a heat shock protein, in platelet functionPrincipal Investigator
- Principal Investigator
  
  KOZAWA Osamu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Gifu University
APPLICATION OF HAIR ANALYSIS TO PREVENT DRUG HAZARDS
- Principal Investigator
  
  UEMATSU Toshihiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  GIFU UNIVERSITY
  Gifu University
Investigation of stress response in osteoblastsPrincipal Investigator
- Principal Investigator
  
  KOZAWA Osamu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Gifu University

[Journal Article] Oncostatin M enhances osteoprotegerin synthesis but reduces macrophage colony-stimulating factor synthesis in bFGF-stimulated osteoblast-like cells.2024
- Author(s)
  Hioki Tomoyuki、Tachi Junko、Ueda Kyohei、Matsushima-Nishiwaki Rie、Iida Hiroki、Kozawa Osamu、Tokuda Haruhiko
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 27 Issue: 1 Pages: 1-9
- DOI
  10.3892/etm.2023.12322
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09438
[Journal Article] Oncostatin M attenuates tumor necrosis factor-α-induced synthesis of macrophage-colony stimulating factor via suppression of Akt in osteoblasts.2023
- Author(s)
  Hioki T, Kuroyanagi G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
- Journal Title
  
  Connect. Tissue Res.
  
  Volume: 64 Issue: 2 Pages: 139-147
- DOI
  10.1080/03008207.2022.2109468
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09438, KAKENHI-PROJECT-19K18471
[Journal Article] Correlation between the complex of small heat shock proteins (HSPBs) and the progression in patients with hepatocellular carcinoma.2022
- Author(s)
  Matsushima-Nishiwaki R, Toyoda H, Maeda A, Kaneoka Y, Kumada T and Kozawa O.
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 732 Pages: 109461-109461
- DOI
  10.1016/j.abb.2022.109461
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08283
[Journal Article] SERMs (selective estrogen receptor modulator) acting as estrogen receptor β agonists in hepatocellular carcinoma cells, inhibit the transforming growth factor-α-induced migration via specific inhibition of AKT signaling pathway.2022
- Author(s)
  Matsushima-Nishiwaki R, Yamada N, Hattori Y, Hosokawa Y, Tachi J, Hori T and Kozawa O.
- Journal Title
  
  PLoS One.
  
  Volume: 17 Issue: 1 Pages: e0262485-e0262485
- DOI
  10.1371/journal.pone.0262485
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08283
[Journal Article] GLP-1 reduces the migration of hepatocellular carcinoma cells via suppression of the stress-activated protein kinase/c-Jun N-terminal kinase pathway.2021
- Author(s)
  Yamada N, Matsushima-Nishiwaki R, Kobayashi K, Tachi J and Kozawa O.
- Journal Title
  
  Arch Biochem Biophys.
  
  Volume: 703 Pages: 108851-108851
- DOI
  10.1016/j.abb.2021.108851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08283
[Journal Article] HSP90 inhibitors strengthen extracellular ATP-stimulated synthesis of interleukin-6 in osteoblasts: Amplification of p38 MAP kinase2021
- Author(s)
  Hioki T, Tokuda H, Nakashima D, Fujita K, Kawabata T, Sakai G, Kim W, Tachi J, Tanabe K, Matsushima-Nishiwaki R, Otsuka T, Iida H, Kozawa O
- Journal Title
  
  Cell Biochem Funct
  
  Volume: 39 Issue: 1 Pages: 88-97
- DOI
  10.1002/cbf.3566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09370
[Journal Article] Cellular Functions of Small Heat Shock Proteins (HSPB) in Hepatocellular Carcinoma.2021
- Author(s)
  Yamada N, Matsushima-Nishiwaki R, Kobayashi K, Takahata S, Toyoda H, Kumada T　and Kozawa O.
- Journal Title
  
  Curr Mol Med.
  
  Volume: 21 Issue: 10 Pages: 1-16
- DOI
  10.2174/1573405617666210204211252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08283
[Journal Article] Cigarette Smoking Cessation Temporarily Enhances the Release of Phosphorylated-HSP27 from Human Platelets2020
- Author(s)
  Onuma T, Iida M, Kito Y, Tanabe K, Kojima A, Nagase K, Uematsu K, Enomoto Y, Doi T, Tokuda H, Ogura S, Iwama T, Kozawa O, Iida H
- Journal Title
  
  Intern. Med.
  
  Volume: 59 Issue: 15 Pages: 1841-1847
- DOI
  10.2169/internalmedicine.4000-19
- NAID
  130007883877
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2020-08-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09370, KAKENHI-PROJECT-19K09410
[Journal Article] Olive polyphenol reduces the collagen-elicited release of phosphorylated HSP27 from human platelets.2020
- Author(s)
  Mizutani D, Onuma T, Tanabe K, Kojima A, Uematsu K, Nakashima D, Doi T, Enomoto Y, Matsushima-Nishiwaki R, Tokuda H, Ogura S, Iida H, Kozawa O, Iwama T.
- Journal Title
  
  Biosci Biotechnol Biochem.
  
  Volume: 34 Issue: 3 Pages: 5-28
- DOI
  10.1080/09168451.2019.1697196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09370, KAKENHI-PROJECT-19K09410, KAKENHI-PROJECT-17K11569
[Journal Article] Heat shock protein 70 positively regulates transforming growth factor-α-induced hepatocellular carcinoma cell migration via the AKT signaling pathway.2020
- Author(s)
  Kobayashi K, Matsushima-Nishiwaki R, Yamada N, Migita S, Hioki T, Mizutani D and Kozawa O.
- Journal Title
  
  Heliyon
  
  Volume: 6 Issue: 9 Pages: e05002-e05002
- DOI
  10.1016/j.heliyon.2020.e05002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08283
[Journal Article] Synergistic effect of collagen and CXCL12 in the low doses on human platelet activation2020
- Author(s)
  Nakashima D, Onuma T, Tanabe K, Kito Y, Uematsu K, Mizutani D, Enomoto Y, Tsujimoto M, Doi T, Matsushima-Nishiwaki R, Tokuda H, Ogura S, Iwama T, Kozawa O, Iida H.
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 10 Pages: e0241139-e0241139
- DOI
  10.1371/journal.pone.0241139
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09370, KAKENHI-PROJECT-19K09410
[Journal Article] Duloxetine strengthens osteoblast activation by prostaglandin E 1: Upregulation of p38 MAP kinase2020
- Author(s)
  Tachi J, Tokuda H, Onuma T, Yamaguchi S, Kim W, Hioki T, Matsushima-Nishiwaki R, Tanabe K, Kozawa O, Iida H
- Journal Title
  
  Prostaglandins Other Lipid Mediat
  
  Volume: 151 Pages: 106481-106481
- DOI
  10.1016/j.prostaglandins.2020.106481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09370
[Journal Article] Tramadol enhances PGF 2α-stimulated osteoprotegerin synthesis in osteoblasts2020
- Author(s)
  Kim W, Tanabe K, Kuroyanagi G, Matsushima-Nishiwaki R, Fujita K, Kawabata T, Sakai G, Tachi J, Hioki T, Nakashima D, Yamaguchi S, Otsuka T, Tokuda H, Kozawa O, Iida H
- Journal Title
  
  Heliyon
  
  Volume: 24 Issue: 8 Pages: e04779-e04779
- DOI
  10.1016/j.heliyon.2020.e04779
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09370, KAKENHI-PROJECT-19K18471
[Journal Article] Smoking cessation effects human platelet activation induce by collagen.2019
- Author(s)
  Kito Y, Iida M, Tanabe K, Onuma T, Tsujimoto M, Nagase K, Tokuda H, Iwama T, Kozawa O.
- Journal Title
  
  Exp Therap Med
  
  Volume: 18 Pages: 3809-3816
- DOI
  10.3892/etm.2019.8025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09370
[Journal Article] HSP90 inhibitors diminish PDGF-BB-induced migration of osteoblasts via suppression of p44/p42 MAP kinase2019
- Author(s)
  Kawabata T, Tokuda H, Fujita K, Matsushima-Nishiwaki R, Sakai G, Tachi J, Hioki T, Kim W, Iida H, Otsuka T, Kozawa O.
- Journal Title
  
  Biomed. Res.
  
  Volume: 40 Issue: 4 Pages: 169-178
- DOI
  10.2220/biomedres.40.169
- NAID
  130007689874
- ISSN
  0388-6107, 1880-313X
- Year and Date
  2019-08-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11002
[Journal Article] Enhancement by HSP90 inhibitor of PGD2-stimulated HSP27 induction in osteoblasts: Suppression of SAPK/JNK and p38 MAP kinase.2019
- Author(s)
  Kim W, Tokuda H, Kawabata T, Fujita K, Sakai G, Nakashima D, Tachi J, Kuroyanagi G, Matsushima-Nishiwaki R, Tanabe K, Otsuka T, Iida H, Kozawa O.
- Journal Title
  
  Prostaglandins Other Lipid Mediat
  
  Volume: 143 Pages: 106327-106327
- DOI
  10.1016/j.prostaglandins.2019.03.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09114, KAKENHI-PROJECT-19K09370, KAKENHI-PROJECT-19K18471, KAKENHI-PROJECT-17K11002
[Journal Article] HSP90 limits thrombin-stimulated IL-6 synthesis in osteoblast-like MC3T3-E1 cells: Regulation of p38 MAPK.2018
- Author(s)
  Fujita K, Otsuka T, Kawabata T, Kainuma S, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 42 Pages: 2185-2192
- DOI
  10.3892/ijmm.2018.3785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11002
[Journal Article] Repression of IGF-I-induced osteoblast migration by (-)-epigallocatechin gallate through p44/p42 MAP kinase signaling.2018
- Author(s)
  Kawabata T, Tokuda H, Sakai G, Fujita K, Matsushima-Nishiwaki R, Otsuka T, Kozawa O.
- Journal Title
  
  Biomed. Rep.
  
  Volume: 9 Pages: 318-326
- DOI
  10.3892/br.2018.1140
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11002
[Journal Article] HSP70 Inhibitors Reduce The Osteoblast Migration By Epidermal Growth Factor.2018
- Author(s)
  Kawabata T, Otsuka T, Fujita K, Sakai G, Kim W, Matsushima-Nishiwaki R, Kuroyanagi G, Kozawa O, Tokuda H.
- Journal Title
  
  Curr. Mol. Med.
  
  Volume: 18 Issue: 7 Pages: 486-495
- DOI
  10.2174/1566524019666181213112847
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11002, KAKENHI-PROJECT-17H07009
[Journal Article] HSP70 Inhibitor Suppresses IGF-I-Stimulated Migration of Osteoblasts through p44/p42 MAP Kinase.2018
- Author(s)
  Kawabata T, Tokuda H, Sakai G, Fujita K, Matsushima-Nishiwaki R, Kuroyanagi G, Otsuka T, Kozawa O.
- Journal Title
  
  Biomedicines.
  
  Volume: 6 Issue: 4 Pages: 109-109
- DOI
  10.3390/biomedicines6040109
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11002, KAKENHI-PROJECT-17H07009
[Journal Article] (-)-Epigallocatechin gallate but not chlorogenic acid suppresses EGF-stimulated migration of osteoblasts via attenuation of p38 MAPK activity.2018
- Author(s)
  Kawabata T, Otsuka T, Fujita K, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 42 Pages: 3149-3156
- DOI
  10.3892/ijmm.2018.3884
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11002
[Journal Article] Inhibitors of heat shock protein 90 augment endothelin-1-induced heat shock protein 27 through the SAPK/JNK signaling pathway in osteoblasts.2018
- Author(s)
  Fujita K, Otsuka T, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
- Journal Title
  
  Mol. Med. Rep.
  
  Volume: 17 Pages: 8542-8547
- DOI
  10.3892/mmr.2018.8878
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11002
[Journal Article] Association of HSP22 with mTOR in osteoblasts: regulation of TNF-α-stimulated IL-6 synthesis2018
- Author(s)
  Sakai Go、Tokuda Haruhiko、Yamamoto Naohiro、Matsushima-Nishiwaki Rie、Fujita Kazuhiko、Kawabata Tetsu、Kozawa Osamu、Otsuka Takanobu
- Journal Title
  
  FEBS Letters
  
  Volume: 592 Issue: 7 Pages: 1202-1210
- DOI
  10.1002/1873-3468.13028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10487, KAKENHI-PROJECT-17K11002
[Journal Article] Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.2018
- Author(s)
  Matsushima-Nishiwaki R, Yamada N, Fukuchi K, Kozawa O.
- Journal Title
  
  PLoS One.
  
  Volume: 13 Issue: 12 Pages: e0209050-e0209050
- DOI
  10.1371/journal.pone.0209050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09417, KAKENHI-PROJECT-16K09350
[Journal Article] Suppression by HSP90 inhibitors of BMP-4-stimulated osteoprotegerin synthesis in osteoblasts: Attenuation of p70 S6 kinase2017
- Author(s)
  Kawabata Tetsu、Otsuka Takanobu、Fujita Kazuhiko、Kainuma Shingo、Yamamoto Naohiro、Kuroyanagi Gen、Sakai Go、Matsushima-Nishiwaki Rie、Kozawa Osamu、Tokuda Haruhiko
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 16 Issue: 6 Pages: 8507-8512
- DOI
  10.3892/mmr.2017.7639
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10487
[Journal Article] HSP90 inhibitors potentiate PGF2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts2017
- Author(s)
  Fujita Kazuhiko、Tokuda Haruhiko、Kuroyanagi Gen、Yamamoto Naohiro、Kainuma Shingo、Kawabata Tetsu、Sakai Go、Matsushima-Nishiwaki Rie、Kozawa Osamu、Otsuka Takanobu
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 5 Pages: e0177878-e0177878
- DOI
  10.1371/journal.pone.0177878
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10487
[Journal Article] Heat shock protein 70 negatively regulates TGF-β-stimulated VEGF synthesis via p38 MAP kinase in osteoblasts.2017
- Author(s)
  Sakai G, Tokuda H, Fujita K, Kainuma S, Kawabata T, Matsushima-Nishiwaki R, Kozawa O, Otsuka T.
- Journal Title
  
  Cell. Physiol. Biochem.
  
  Volume: 44 Issue: 3 Pages: 1133-1145
- DOI
  10.1159/000485418
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11002, KAKENHI-PROJECT-15K10487
[Journal Article] Heat shock protein 22 (HSPB8) reduces the migration of hepatocellular carcinoma cells through the suppression of the phosphoinositide 3-kinase (PI3K)/AKT pathway.2017
- Author(s)
  Matsushima-Nishiwaki R, Toyoda H, Takamatsu R, Yasuda E, Okuda S, Maeda A, Kaneoka Y, Yoshimi N, Kumada T, Kozawa O.
- Journal Title
  
  Biochim. Biophys Acta-Mol. Basis Dis.
  
  Volume: 1863 Issue: 6 Pages: 1629-1639
- DOI
  10.1016/j.bbadis.2017.04.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09350
[Journal Article] Heat shock protein 27 (HSPB1) suppresses the PDGF-BB-induced migration of osteoblasts2017
- Author(s)
  Kainuma Shingo、Tokuda Haruhiko、Yamamoto Naohiro、Kuroyanagi Gen、Fujita Kazuhiko、Kawabata Tetsu、Sakai Go、Matsushima-Nishiwaki Rie、Kozawa Osamu、Otsuka Takanobu
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume: 40 Issue: 4 Pages: 1057-1066
- DOI
  10.3892/ijmm.2017.3119
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10487
[Journal Article] Factor Xa inhibitor suppresses the release of phosphorylated HSP27 from collagen-stimulated human platelets: inhibition of HSP27 phosphorylation via p44/p42 MAP kinase.2016
- Author(s)
  Tsujimoto M, Kuroyanagi G, Matsushima-Nishiwaki R, Kito Y, Enomoto Y, Iida H, Ogura S, Otsuka T, Tokuda H, Kozawa O and Iwama T.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 4 Pages: e0151907-e0151907
- DOI
  10.1371/journal.pone.0151907
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462335, KAKENHI-PROJECT-25460989, KAKENHI-PROJECT-16K09350
[Journal Article] Regulation by AMP-activated protein kinase of PGE2-induced osteoprotegerin synthesis in osteoblasts.2016
- Author(s)
  Kainuma S, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O and Tokuda H.
- Journal Title
  
  Mol Med Rep.
  
  Volume: 4 Issue: 4 Pages: 3363-3369
- DOI
  10.3892/mmr.2016.4900
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462289, KAKENHI-PROJECT-26462309
[Journal Article] Thrombin Receptor-Activating Protein (TRAP)-Activated Akt Is Involved in the Release of Phosphorylated-HSP27 (HSPB1) from Platelets in DM Patients.2016
- Author(s)
  Tokuda H, Kuroyanagi G, Tsujimoto M, Matsushima-Nishiwaki R, Akamatsu S, Enomoto Y, Iida H, Otsuka T, Ogura S, Iwama T, Kojima K, Kozawa O.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 17 Issue: 5 Pages: 737-737
- DOI
  10.3390/ijms17050737
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462309, KAKENHI-PROJECT-26462335, KAKENHI-PROJECT-15K10509
[Journal Article] cAMP/PKA enhances interleukin-1β-induced interleukin-6 synthesis through STAT3 in glial cells2016
- Author(s)
  Tanabe K, Kozawa O, Iida H
- Journal Title
  
  Cell Signal
  
  Volume: 28 Issue: 1 Pages: 19-24
- DOI
  10.1016/j.cellsig.2015.10.009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462334
[Journal Article] Possible involvement of AMP-activated protein kinase in PGE1-induced synthesis of osteoprotegerin in osteoblasts.2016
- Author(s)
  Kainuma S, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O and Tokuda H.
- Journal Title
  
  Exp Ther Med.
  
  Volume: 5 Pages: 2042-2048
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462289
[Journal Article] Heat shock protein 22 (HSPB8) limits TGF-β-stimulated migration of osteoblasts.2016
- Author(s)
  Yamamoto N, Tokuda H, Kuroyanagi G, Kainuma S, Matsushima-Nishiwaki R, Fujita K, Kozawa O, Otsuka T.
- Journal Title
  
  Mol Cell Endocrinol
  
  Volume: 436 Pages: 1-9
- DOI
  10.1016/j.mce.2016.07.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462309, KAKENHI-PROJECT-15K10487
[Journal Article] AICAR reduces collagen-stimulated secretion of PDGF-AB and release of soluble CD40 ligand from human platelets: suppression of HSP27 phosphorylation via p44/p42 MAP kinase.2016
- Author(s)
  Tsujimoto M, Tokuda H, Kuroyanagi G, Yamamoto N, Kainuma S, Matsushima-Nishiwaki R, Onuma T, Iida Y, Kojima A, Sawada S, Doi T, Enomoto Y, Tanabe K, Akamatsu S, Iida H, Ogura S, Otsuka T, Kozawa O and Iwama T
- Journal Title
  
  Exp Ther Med.
  
  Volume: 12 Pages: 1107-1112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462335
[Journal Article] Resveratrol reduces prostaglandin E1-stimulated osteoprotegerin synthesis in osteoblasts: Suppression of stress-activated protein kinase/c-Jun N-terminal kinase.2015
- Author(s)
  Yamamoto N, Otsuka T, Kuroyanagi G, Kondo A, Kainuma S, Nakakami A, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
- Journal Title
  
  Prostaglandins Other Lipid Mediat.
  
  Volume: 116-117 Pages: 57-63
- DOI
  10.1016/j.prostaglandins.2015.01.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592273
[Journal Article] Heat shock protein 20 (HSPB6) regulates TNF-α-induced intracellular signaling pathway in human hepatocellular carcinoma cells.2015
- Author(s)
  Nagasawa T, Matsushima-Nishiwaki R, Yasuda E, Matsuura J, Toyoda H, Kaneoka Y, Kumada T, Kozawa O.
- Journal Title
  
  Arch Biochem Biophys.
  
  Volume: 565 Pages: 1-8
- DOI
  10.1016/j.abb.2014.10.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592273
[Journal Article] PGD2 stimulates osteoprotegerin synthesis via AMP-activated protein kinase in osteoblasts: regulation of ERK and SAPK/JNK.2015
- Author(s)
  Kainuma S, Tokuda H, Kuroyanagi G, Yamamoto N, Ohguchi R, Fujita K, Matsushima-Nishiwaki R, Kozawa O and Otsuka T.
- Journal Title
  
  Prostaglandins Leukot. Essent. Fatty Acids.
  
  Volume: 101 Pages: 23-29
- DOI
  10.1016/j.plefa.2015.08.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462289
[Journal Article] Rac limits TGF-β-induced VEGF synthesis in osteoblasts. Mol Cell Endocrinol.2015
- Author(s)
  Yamamoto N, Otsuka T, Kondo A, Matsushima-Nishiwaki R, Kuroyanagi G, Kozawa O, Tokuda H.
- Journal Title
  
  Mol Cell Endocrinol
  
  Volume: 405 Pages: 35-41
- DOI
  10.1016/j.mce.2015.02.002
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592272, KAKENHI-PROJECT-24592273
[Journal Article] Rho-kinase regulates human platelet activation induced by thromboxane A2 independently of p38 MAP kinase.2015
- Author(s)
  Iida Y, Doi T, Tokuda H, Matsushima-Nishiwaki R, Tsujimoto M, Kuroyanagi G, Yamamoto N, Enomoto Y, Tanabe K, Otsuka T, Iwama T, Ogura S, Kozawa O, Iida H.
- Journal Title
  
  Prostaglandins Leukot Essent Fatty Acids.
  
  Volume: 94 Pages: 73-81
- DOI
  10.1016/j.plefa.2014.11.006
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592273, KAKENHI-PROJECT-24592294, KAKENHI-PROJECT-26462334
[Journal Article] Regulation by heat shock protein 22 (HSPB8) of transforming growth factor-α-induced ovary cancer cell migration.2015
- Author(s)
  Suzuki M, Matsushima-Nishiwaki R, Kuroyanagi G, Suzuki N, Takamatsu R, Furui T, Yoshimi N, Kozawa O, Morishige K.
- Journal Title
  
  Arch Biochem Biophys.
  
  Volume: 571 Pages: 40-49
- DOI
  10.1016/j.abb.2015.02.030
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592273, KAKENHI-PROJECT-26462519
[Journal Article] αB-crystallin reduces ristocetin‑induced soluble CD40 ligand release in human platelets: Suppression of thromboxane A2 generation.2015
- Author(s)
  Tsujimoto M, Doi T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Iida Y, Enomoto Y, Iida H, Ogura S, Otsuka T, Tokuda H, Kozawa O, Iwama T.
- Journal Title
  
  Mol Med Rep.
  
  Volume: 12(1) Issue: 1 Pages: 357-362
- DOI
  10.3892/mmr.2015.3445
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592273
[Journal Article] Differential effects of intravenous anesthetics on PDGF-BB-induced vascular smooth muscle cell migration.2014
- Author(s)
  Iida M, Tanabe K, Kozawa O, Iida H.
- Journal Title
  
  Cell Physiol Biochem.
  
  Volume: 33(6) Issue: 6 Pages: 1827-1837
- DOI
  10.1159/000362961
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592273, KAKENHI-PROJECT-24592294, KAKENHI-PROJECT-26462334, KAKENHI-PROJECT-26861227
[Journal Article] Resveratrol inhibits BMP-4-stimulated VEGF synthesis in osteoblasts: suppression of S6 kinase.2014
- Author(s)
  Kondo A, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Mizutani J, Kozawa O, Tokuda H.
- Journal Title
  
  Int J Mol Med.
  
  Volume: 33(4) Issue: 4 Pages: 1013-1018
- DOI
  10.3892/ijmm.2014.1626
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592273, KAKENHI-PROJECT-26462309
[Journal Article] Dexmedetomidine suppresses interleukin-1β-induced interleukin-6 synthesis in rat glial cells.2014
- Author(s)
  Tanabe K, Matsushima-Nishiwaki R, Kozawa O, Iida H.
- Journal Title
  
  Int J Mol Med.
  
  Volume: 34(4) Issue: 4 Pages: 1032-1038
- DOI
  10.3892/ijmm.2014.1863
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592273, KAKENHI-PROJECT-24592294, KAKENHI-PROJECT-26462334
[Journal Article] Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts.2014
- Author(s)
  Kuroyanagi G, Mizutani J, Kondo A, Yamamoto N, Matsushima-Nishiwaki R, Otsuka T, Kozawa O, Tokuda H.
- Journal Title
  
  Prostaglandins Leukot Essent Fatty Acids.
  
  Volume: S0952-3278(14) Issue: 3 Pages: 72-76
- DOI
  10.1016/j.plefa.2014.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592273, KAKENHI-PROJECT-26462309
[Journal Article] Involvement of Rac in thromboxane A2-induced human platelet activation: Regulation of sCD40 ligand release and PDGF-AB secretion.2014
- Author(s)
  Kageyama Y, Doi T, Matsushima-Nishiwaki R, Iida Y, Akamatsu S, Kondo A, Kuroyanagi G, Yamamoto N, Mizutani J, Otsuka T, Tokuda H, Iida H, Kozawa O, Ogura S.
- Journal Title
  
  Mol Med Rep.
  
  Volume: 10(1) Issue: 1 Pages: 107-12
- DOI
  10.3892/mmr.2014.2143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592273, KAKENHI-PROJECT-24592294, KAKENHI-PROJECT-26462335
[Journal Article] Heat shock protein 20 (HSPB6) regulates apoptosis in human hepatocellular carcinoma cells: Direct association with Bax.2014
- Author(s)
  Nagasawa T, Matsushima-Nishiwaki R, Toyoda H, Matsuura J, Kumada T, Kozawa O.
- Journal Title
  
  Oncol Rep.
  
  Volume: 32(3) Issue: 3 Pages: 1291-1295
- DOI
  10.3892/or.2014.3278
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592273, KAKENHI-PROJECT-25460989
[Journal Article] Dexmedetomidine suppresses interleukin-1β-induced interleukin-6 synthesis in rat glial cells.2014
- Author(s)
  Tanabe K, Matsushima-Nishiwaki R, Kozawa O, Iida H
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume: In Press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592248
[Journal Article] Resveratrol suppresses prostaglandin F(2α)-induced osteoprotegerin synthesis in osteoblasts: inhibition of the MAP kinase signaling.2014
- Author(s)
  Kuroyanagi G, Tokuda H, Matsushima-Nishiwaki R, Kondo A, Mizutani J, Kozawa O, Otsuka T.
- Journal Title
  
  Arch Biochem Biophys.
  
  Volume: 542 Pages: 39-45
- DOI
  10.1016/j.abb.2013.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592273, KAKENHI-PROJECT-26462289
[Journal Article] Down-regulation by resveratrol of basic fibroblast growth factor-stimulated osteoprotegerin synthesis through suppression of Akt in osteoblasts.2014
- Author(s)
  Kuroyanagi G, Otsuka T, Yamamoto N, Matsushima-Nishiwaki R, Nakakami A, Mizutani J, Kozawa O, Tokuda H.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 15(10) Issue: 10 Pages: 17886-17900
- DOI
  10.3390/ijms151017886
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592273
[Journal Article] Dexmedetomidine suppresses interleukin-1β-induced interleukin-6 synthesis in rat glial cells2014
- Author(s)
  Tanabe K, Matsushima-Nishiwaki R, Kozawa O, Iida H
- Journal Title
  
  Int J Mol Med
  
  Volume: (In Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592248
[Journal Article] Involvement of Rac in thromboxane A2-induced human platelet activation : regulation of sCD40 ligand release and PDGF-AB secretion2014
- Author(s)
  Kageyama Y, Doi T, Matsushima-Nishiwaki R, Iida Y, Akamatsu S, Kondo A, Kuroyanagi G, Yamamoto N, Mizutani J, Otsuka T, Tokuda H, Iida H, Kozawa O and Ogura S
- Journal Title
  
  Mol. Med. Rep.
  
  Volume: 10 Pages: 107-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592249
[Journal Article] Down-regulation by resveratrol of basic fibroblast growth factor-stimulated osteoprotegerin synthesis through suppression of Akt in osteoblasts.2014
- Author(s)
  Kuroyanagi G, Otsuka T, Yamamoto N, Matsushima-Nishiwaki R, Nakakami A, Mizutani J, Kozawa O, Tokuda H.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 15 Issue: 5 Pages: 17886-900
- DOI
  10.3892/ijmm.2014.1934
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592272, KAKENHI-PROJECT-24592273
[Journal Article] (-)-Epigallocatechin gallate selectively inhibits adenosine diphosphate‑stimulated human platelet activation: suppression of heat shock protein 27 phosphorylation via p38 mitogen‑activated protein kinase.2014
- Author(s)
  Iida Y, Doi T, Matsushima-Nishiwaki R, Tokuda H, Ogura S, Kozawa O, Iida H.
- Journal Title
  
  Mol Med Rep.
  
  Volume: 10(3) Issue: 3 Pages: 1383-1388
- DOI
  10.3892/mmr.2014.2389
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592273, KAKENHI-PROJECT-24592294
[Journal Article] Rho-kinase limits BMP-4-stimulated osteocalcin synthesis in osteoblasts: regulation of the p38 MAP kinase pathway.2014
- Author(s)
  Kondo A, Tokuda H, Matsushima-Nishiwaki R, Kuroyanagi G, Yamamoto N, Mizutani J, Kozawa O, Otsuka T.
- Journal Title
  
  Life Sci.
  
  Volume: 96(1-2) Issue: 1-2 Pages: 18-25
- DOI
  10.1016/j.lfs.2013.12.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592273
[Journal Article] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer2013
- Author(s)
  Osawa Y, Yasuda I, Kozawa O, et al.
- Journal Title
  
  J Clin Invest
  
  Volume: 123 Pages: 834-43
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] Tumor necrosis factor-αpromotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells2013
- Author(s)
  Osawa Y, Yasuda I, Kozawa O, et al.
- Journal Title
  
  PLoS One
  
  Volume: 8 Pages: 65251-65251
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] Thrombopoietin amplifies ADP-induced HSP27 phosphorylation in human platelets : importance of its pre-treatment2013
- Author(s)
  Cuong TN, Doi T, Matsushima-Nishiwaki R, Akamatsu S, Kuroyanagi G, Kondo A, Mizutani J, Wada I, Otsuka T, Tokuda H, Kozawa O and Ogura S
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 31 Pages: 1291-1297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592249
[Journal Article] Effect of antithrombin III on glycoprotein Ib/IX/V activation in human platelets : suppression of thromboxane A2 generation2013
- Author(s)
  Doi T, Tokuda H, Matsushima-Nishiwaki R, Cuong NT, Kageyama Y, Iida Y, Kondo A, Akamatsu S, Otsuka T, Iida H, Kozawa O and Ogura S
- Journal Title
  
  Prostaglandins Leukot. Essent. Fatty Acids
  
  Volume: 87 Pages: 57-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592249
[Journal Article] Thrombopoietin amplifies ADP-induced HSP27 phosphorylation in human platelets: importance of its pre-treatment.2013
- Author(s)
  Cuong TN, Doi T, Matsushima-Nishiwaki R, Akamatsu S, Kuroyanagi G, Kondo A, Mizutani J, Wada I, Otsuka T, Tokuda H, Kozawa O, Ogura S.
- Journal Title
  
  J. Mol. Med.
  
  Volume: 31 Issue: 6 Pages: 1291-1297
- DOI
  10.3892/ijmm.2013.1345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592249, KAKENHI-PROJECT-24592273
[Journal Article] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer．2013
- Author(s)
  Osawa Y,Saibara T et.al
- Journal Title
  
  Journal Clin Invest
  
  Volume: 123(2) Pages: 834-843
- DOI
  10.1172/jci65188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-23591013, KAKENHI-PROJECT-23790787, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-24890081, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-221S0001
[Journal Article] Rac regulates collagen-induced HSP27 phosphorylation via p44/p42 MAP kinase in human platelets2013
- Author(s)
  Kageyama Y, Doi T, Akamatsu S, Kuroyanagi G, Kondo A, Mizutani J, Otsuka T, Tokuda H, Kozawa O and Ogura S
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 32 Pages: 813-818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592249
[Journal Article] (-)-Epigallocatechin gallate amplifies interleukin-1-stimulated interleukin-6 synthesis in osteoblast-like MC3T3-E1 cells.2013
- Author(s)
  Kuroyanagi G, Otsuka T, Kondo A, Matsushima-Nishiwaki R, Mizutani J, Kozawa O, Tokuda H.
- Journal Title
  
  Biochimie.
  
  Volume: 95(10) Issue: 10 Pages: 1933-1938
- DOI
  10.1016/j.biochi.2013.07.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592273
[Journal Article] Tumor necrosis factor-α promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of　metalloproteinase-1 production in hepatic stellate cells．2013
- Author(s)
  Osawa Y,Saibara T et.al
- Journal Title
  
  PloS One
  
  Volume: 8（6） Issue: 6 Pages: e65251-e65251
- DOI
  10.1371/journal.pone.0065251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-23591013, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-24890270, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-221S0001
[Journal Article] Unphosphorylated HSP27 plays a suppressive role in FGF-2-stimulated VEGF release in osteoblasts.2013
- Author(s)
  Kondo A, Tokuda H, Matsushima-Nishiwaki R, Kato K, Kuroyanagi G, Mizutani J, Fukuoka M, Wada I, Kozawa O, Otsuka T.
- Journal Title
  
  Mol. Med. Rep.
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592273
[Journal Article] Rho-kinase negatively regulates thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.2013
- Author(s)
  Kondo A, Tokuda H, Kato K, Matsushima-Nishiwaki R, Kuroyanagi G, Mizutani J, Kozawa O, Otsuka T.
- Journal Title
  
  Biochimie
  
  Volume: 95 Issue: 4 Pages: 719-24
- DOI
  10.1016/j.biochi.2012.10.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592272, KAKENHI-PROJECT-24592273
[Journal Article] Direct association of heat shock protein 20 (HSPB6) with phosphoinositide 3-kinase (PI3K) in human hepatocellular carcinoma: regulation of the PI3K activity.2013
- Author(s)
  Matsushima-Nishiwaki R, Kumada T, Nagasawa T, Suzuki M, Yasuda E, Okuda S, Maeda A, Kaneoka Y, Toyoda H, Kozawa O.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 11 Pages: e78440-e78440
- DOI
  10.1371/journal.pone.0078440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460989
[Journal Article] AMP-activated protein kinase regulates thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.2013
- Author(s)
  Kondo A, Otsuka T, Kato K, Matsushima-Nishiwaki R, Kuroyanagi G, Mizutani J, Tokuda H, Kozawa O.
- Journal Title
  
  Int J Mol Med.
  
  Volume: 31(6) Issue: 6 Pages: 1457-62
- DOI
  10.3892/ijmm.2013.1349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592273
[Journal Article] Rac regulates collagen-induced HSP27 phosphorylation via p44/p42 MAP kinase in human platelets.2013
- Author(s)
  Kageyama Y, Doi T, Akamatsu S, Kuroyanagi G, Kondo A, Mizutani J, Otsuka T, Tokuda H, Kozawa O, Ogura S.
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 32 Issue: 4 Pages: 813-818
- DOI
  10.3892/ijmm.2013.1455
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592249, KAKENHI-PROJECT-24592273
[Journal Article] Inhibition of SAPK/JNK leads to enhanced IL-1-induced IL-6 synthesis in osteoblasts.2013
- Author(s)
  Kondo A, Otsuka T, Matsushima-Nishiwaki R, Kuroyanagi G, Mizutani J, Wada I, Kozawa O, Tokuda H.
- Journal Title
  
  Arch Biochem Biophys.
  
  Volume: 535(2) Issue: 2 Pages: 227-33
- DOI
  10.1016/j.abb.2013.04.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592273
[Journal Article] Unphosphorylated heat shock protein 27 suppresses fibroblast growth factor-2-stimulated vascular endothelial growth factor release in osteoblasts.2013
- Author(s)
  Kondo A, Tokuda H, Matsushima-Nishiwaki R, Kato K, Kuroyanagi G, Mizutani J, Fukuoka M, Wada I, Kozawa O, Otsuka T.
- Journal Title
  
  Mol Med Rep
  
  Volume: 8 Issue: 2 Pages: 691-695
- DOI
  10.3892/mmr.2013.1533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592272, KAKENHI-PROJECT-24592273
[Journal Article] AMP-activated protein kinase regulates PDGF-BB-stimulated interleukin-6 synthesis in osteoblasts: involvement of mitogen-activated protein kinases.2012
- Author(s)
  Kato K, Otsuka T, Kondo A, Matsushima-Nishiwaki R, Natsume H, Kozawa O, Tokuda H.
- Journal Title
  
  Life Sci.
  
  Volume: 90 Issue: 1-2 Pages: 71-76
- DOI
  10.1016/j.lfs.2011.10.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592273
[Journal Article] Significant correlation between the acceleration of platelet aggregation and phosphorylation of HSP27 at Ser-78 in diabetic patients2012
- Author(s)
  Tokuda H, Kato K, Kasahara S, Matsushima-Nishiwaki R, Mizuno T, Sakakibara S and Kozawa O
- Journal Title
  
  Int. J. Mol. Med
  
  Volume: 30 Pages: 1387-1395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592249
[Journal Article] Involvement of phosphatidylinositol 3-kinase/Akt on basic fibroblast growth factor-induced glial cell line-derived neurotrophic factor release from rat glioma cells2012
- Author(s)
  Tanabe K, Matsushima-Nishiwaki R, Iida M, Kozawa O, Iida H
- Journal Title
  
  Brain Res
  
  Volume: 1463 Pages: 21-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592248
[Journal Article] AMP-activated protein kinase inhibitor decreases prostaglandin F2α-stimulated interleukin-6 synthesis through p38 MAP kinase in osteoblasts.2012
- Author(s)
  Kondo A, Otsuka T, Kato K, Natsume H, Kuroyanagi G, Mizutani J, Ito Y, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 30 Issue: 6 Pages: 1487-1492
- DOI
  10.3892/ijmm.2012.1159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592273
[Journal Article] Wnt3a upregulates prostaglandin F2α-stimulated vascular endothelial growth factor　synthesis in osteoblasts.2012
- Author(s)
  Kondo A, Tokuda H, Mizutani J, Matsushima-Nishiwaki R, Kozawa O, Otsuka T.
- Journal Title
  
  Mol Med Report.
  
  Volume: 6 Issue: 2 Pages: 421-425
- DOI
  10.3892/mmr.2012.916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592272, KAKENHI-PROJECT-24592273
[Journal Article] Effect of antithrombin III on glycoprotein Ib/IX/V activation in human platelets: suppression of thromboxane A2 generation.2012
- Author(s)
  Doi T
- Journal Title
  
  Prostaglandins Leukot Essent Fatty Acids
  
  Volume: 87 Issue: 2-3 Pages: 57-62
- DOI
  10.1016/j.plefa.2012.05.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591705, KAKENHI-PROJECT-23592249, KAKENHI-PROJECT-24592294
[Journal Article] Cisplatin and ultra-violet-C synergistically down-regulate receptor tyrosine kinases in human colorectal cancer cells.2012
- Author(s)
  Kawaguchi J, Adachi S, Yasuda I, Yamauchi T, Nakashima M, Ohno T, Shimizu M, Yoshioka T, Itani M, Kozawa O and Moriwaki H.
- Journal Title
  
  Mol. Cancer.
  
  Volume: 11巻 Issue: 1 Pages: 45-45
- DOI
  10.1186/1476-4598-11-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726, KAKENHI-PROJECT-23591013, KAKENHI-PROJECT-24590939
[Journal Article] Involvement of phosphatidylinosiol 3-kinase/Akt on basic fibroblast growth factor-induced glial cell line-derived neurotrophic factor release from rat glioma cells.2012
- Author(s)
  Tanabe K
- Journal Title
  
  Brain Reseach.
  
  Volume: 1463 Pages: 21-29
- DOI
  10.1016/j.brainres.2012.04.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591705, KAKENHI-PROJECT-23592248, KAKENHI-PROJECT-24592294
[Journal Article] Cisplatin and ultra-violet-C synergistically down-regulate receptor tyrosine kinases in human colorectal cancer cells2012
- Author(s)
  Kawaguchi J, Adachi S, Yasuda I, Kozawa O, et al.
- Journal Title
  
  Mol Cancer
  
  Volume: 12
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] UVC irradiation suppresses platelet-derived growth factor-BB-induced migration in human pancreatic cancer cells2012
- Author(s)
  Kawaguchi J, Adachi S, Yasuda I, Kozawa O, et al.
- Journal Title
  
  Oncol Rep
  
  Volume: 27 Pages: 935-9
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] Involvement of AMP-activated protein kinase in thrombin-stimulated interleukin-6 synthesis in osteoblasts.2012
- Author(s)
  Tokuda H, Kato K, Natsume H, Kondo A, Kuroyanagi G, Matsushima-Nishiwaki R, Ito Y, Otsuka T, Kozawa O.
- Journal Title
  
  J. Mol. Endocrinol.
  
  Volume: 49 Issue: 1 Pages: 47-55
- DOI
  10.1530/jme-11-0165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592273
[Journal Article] UVC irradiation suppresses platelet-derived growth factor-BB-induced migration in human pancreatic cancer cells.2012
- Author(s)
  Kawaguchi J, Adachi S, Yasuda I, Yamauchi T, Yoshioka T, Itani M, Kozawa O and Moriwaki H.
- Journal Title
  
  Oncol. Rep.
  
  Volume: 27巻 Issue: 4 Pages: 935-939
- DOI
  10.3892/or.2011.1612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726, KAKENHI-PROJECT-23591013, KAKENHI-PROJECT-24590939
[Journal Article] Involvement of AMP-activated protein kinase in TGF-α-stimulated VEGF synthesis in osteoblasts.2012
- Author(s)
  Mizutani J, Tokuda H, Matsushima-Nishiwaki R, Kato K, Kondo A, Natsume H, Kozawa O, Otsuka T.
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 29 Issue: 4 Pages: 550-556
- DOI
  10.3892/ijmm.2012.893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592273
[Journal Article] Significant correlation between the acceleration of platelet aggregation and phosphorylation of HSP27 at Ser-78 in diabetic patients.2012
- Author(s)
  okuda H, Kato K, Kasahara S, Matsushima-Nishiwaki R, Mizuno T, Sakakibara S and Kozawa O.
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 30巻 Issue: 6 Pages: 1387-1395
- DOI
  10.3892/ijmm.2012.1146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] AMPK limits IL-1-stimulated IL-6 synthesis in osteoblasts: involvement of IκB/NF-κB pathway.2012
- Author(s)
  Kato K, Tokuda H, Matsushima-Nishiwaki R, Natsume H, Kondo A, Ito Y, Kozawa O,　Otsuka T.
- Journal Title
  
  Cell Signal
  
  Volume: 24 Issue: 8 Pages: 1706-1712
- DOI
  10.1016/j.cellsig.2012.04.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592272, KAKENHI-PROJECT-24592273
[Journal Article] cAMP regulates ADP-induced HSP27 phosphorylation in human platelets.2011
- Author(s)
  Enomoto Y, Adachi S, Doi T, Natsume H, Kato K, Matsushima-Nishiwaki R, Akamatsu S, Tokuda H, Yoshimura S, Otsuka T, Ogura S, Kozawa O and Iwama T.
- Journal Title
  
  Int. J. Mol. Med. 2011;27:695-700.
  
  Volume: 27 Pages: 695-700
- NAID
  120006341953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592249
[Journal Article] Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells2011
- Author(s)
  Tanabe K, Kozawa O, Iida H
- Journal Title
  
  Journal of Neuroinflammmation
  
  Volume: 8 Issue: 1 Pages: 68-68
- DOI
  10.1186/1742-2094-8-68
- NAID
  120006341957
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591970, KAKENHI-PROJECT-22591705, KAKENHI-PROJECT-23592248
[Journal Article] cAMP regulates ADP-induced HSP27 phosphorylation in human platelets2011
- Author(s)
  Enomoto Y, Adachi S, Doi T, Natsume H, Kato K, Matsushima-Nishiwaki R, Akamatsu S, Tokuda H, Yoshimura S, Otsuka T, Ogura S, Kozawa O and Iwama T
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 27 Pages: 695-700
- NAID
  120006341953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592249
[Journal Article] Ultra-violet irradiation induces apoptosis via mitochondrial pathway in pancreatic cancer cells2011
- Author(s)
  Yamauchi T, Adachi S, Yasuda I, Kozawa O, et al.
- Journal Title
  
  Int J Oncol
  
  Volume: 39 Pages: 1375-1380
- NAID
  120006341977
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] Role of HSP27 in tumor necrosis factor-α-stimulated interleukin-6 synthesis in osteoblasts.2011
- Author(s)
  Kato K, Tokuda H, Mizutani J, Adachi S, Matsushima-Nishiwaki R, Natsume H, Kozawa O and Otsuka T .
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 28巻 Pages: 887-893
- DOI
  10.3892/ijmm.2011.762
- NAID
  120006341975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Regulation by heat shock protein 27 ofosteocalcin synthesis in osteoblasts.2011
- Author(s)
  Kato K, Adachi S, Matsushima-Nishiwaki R, Minamitani C,Natsume H, Katagiri Y, Hirose Y, Mizutani J, Tokuda H, Kozawa O and Otsuka T.
- Journal Title
  
  Endocrinology.
  
  Volume: 152巻 Issue: 5 Pages: 1872-1882
- DOI
  10.1210/en.2010-1062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Rho-kinase inhibitor upregulates migration by altering focal adhesion formation via the Akt pathway in colon cancer cells2011
- Author(s)
  Adachi S, Yasuda I, Kozawa O, et al.
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 650 Pages: 145-150
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] UV-C irradiation induces downregulation of EGF receptor via phosphorylation at serine 1046/1047 in human pancreatic cancer cells.2011
- Author(s)
  Yamauchi T, Adachi S, Yasuda I, Nakashima M, Kawaguchi J, Nishii Y, Yoshioka T, Okano Y, Hirose Y, Kozawa O, Moriwaki H.
- Journal Title
  
  Radiation Res
  
  Volume: 176 Pages: 565-574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] Rho-kinase inhibitor upregulates migration by altering focal adhesion formation via the Akt pathway in colon cancer cells.2011
- Author(s)
  Adachi S, Yasuda I, Nakashima M, Yamauchi T, Yoshioka T, Okano Y, Moriwaki H and Kozawa O.
- Journal Title
  
  Eur. J. Pharmacol.
  
  Volume: 650巻 Issue: 1 Pages: 145-150
- DOI
  10.1016/j.ejphar.2010.10.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Role of heat shock protein 27 in transforming growth factor-β-stimulatedvascular endothelial growth factor release in osteoblasts.2011
- Author(s)
  Kato K, Tokuda H, Adachi S, Matsushima-Nishiwaki R, Yamauchi J, Natsume H, Minamitani C, Mizutani J,Otsuka T and Kozawa O.
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 27巻 Issue: 3 Pages: 423-428
- DOI
  10.3892/ijmm.2011.595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Suppression by heat shock protein 20 of hepatocellular carcinoma cell proliferation via inhibition of the mitogen-activated protein kinases and Akt pathways.2011
- Author(s)
  Matsushima-Nishiwaki R, Adachi S,Yoshioka T, Yasuda E, Yamagishi Y, Matsuura J, Muko M, Iwamura R, NodaT, Toyoda H, Kaneoka Y, Okano Y, Kumada T and Kozawa O.
- Journal Title
  
  J. Cell. Biochem.
  
  Volume: 112巻 Issue: 11 Pages: 3430-3439
- DOI
  10.1002/jcb.23270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Rho-kinase inhibitor upregulates migration by altering focal adhesion formation via the Akt pathway in colon cancer cells.2011
- Author(s)
  Adachi S, Yasuda I, Nakashima M, Yamauchi T, Yoshioka T, Okano Y, Moriwaki H, Kozawa O.
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 650 Pages: 145-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] UV-C irradiation induces downregulation of EGF receptor via phosphorylation at Serine 1046/1047 in human pancreatic cancer cells2011
- Author(s)
  Yamauchi T, Adachi S, Yasuda I, Kozawa O, et al.
- Journal Title
  
  Radiat Res
  
  Volume: 176 Pages: 565-574
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] UV-C irradiation induces downregulationof EGF receptors via phosphorylation at serine 1046/1047 in human pancreatic cancer cells.2011
- Author(s)
  Yamauchi T, Adachi S, Yasuda I, Nakashima M, Kawaguchi J, Nishii Y, Yoshioka T, Okano Y, Hirose Y, Kozawa O and Moriwaki H.
- Journal Title
  
  Radiat. Res.
  
  Volume: 176巻 Pages: 565-574
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21692654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor2011
- Author(s)
  Adachi S, Yasuda I, Kozawa O, et al.
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 26178-26187
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells.2011
- Author(s)
  Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Hanamatsu T,Yoshioka T , Okano Y, Hirose Y, Kozawa O and Moriwaki H.
- Journal Title
  
  Mol. Cancer.
  
  Volume: 10巻 Pages: 79-79
- NAID
  120006341951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells2011
- Author(s)
  Nakashima M, Adachi S, Yasuda I, Kozawa O, et al.
- Journal Title
  
  Molecular Cancer
  
  Volume: 10 Pages: 79-79
- NAID
  120006341951
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] Ultra-violet irradiation induces apoptosis via mitochondrial pathway in pancreatic cancer cells.2011
- Author(s)
  Yamauchi T, Adachi S, Yasuda I, Nakashima M, Kawaguchi J, Yoshioka T,Hirose Y, Kozawa O and Moriwaki H.
- Journal Title
  
  Int. J. Oncol.
  
  Volume: 39巻 Pages: 1375-1380
- DOI
  10.3892/ijo.2011.1188
- NAID
  120006341977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Ultraviolet enhances the sensitivity of pancreatic cancer cells to gemcitabine by activation of 5' AMP-activated protein kinase2011
- Author(s)
  Adachi S, Yasuda I, Kawaguchi J, Yamauchi T, Nakashima M, Itani M, Nakamura M, Yoshioka T, Moriwaki H, Kozawa O
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 414 Pages: 53-59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells.2011
- Author(s)
  Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Itani M, Yoshioka T, Matsushima-Nishiwaki R, Hirose Y, Kozawa O, Moriwaki H.
- Journal Title
  
  Cancer Lett
  
  Volume: 313 Pages: 218-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] cAMP regulates ADP-induced HSP27 phosphorylation in human platelets.2011
- Author(s)
  Enomoto Y, Adachi S, Doi T, Natsume H, Kato K, Matsushima-Nishiwaki R, Akamatsu S, Tokuda H, Yoshimura S, Otsuka T, Ogura S, Kozawa O and Iwama T .
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 27巻 Issue: 5 Pages: 695-700
- DOI
  10.3892/ijmm.2011.637
- NAID
  120006341953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells.2011
- Author(s)
  Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Hanamatsu T, Yoshioka T, Okano Y, Hirose Y, Kozawa O, Moriwaki H.
- Journal Title
  
  Mol Cancer
  
  Volume: 10 Pages: 79-79
- NAID
  120006341951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells.2011
- Author(s)
  Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Itani M, Yoshioka T, Matsushima-Nishiwaki R, Hirose Y, Kozawa O and Moriwaki H.
- Journal Title
  
  Cancer Lett.
  
  Volume: 313巻 Issue: 2 Pages: 218-225
- DOI
  10.1016/j.canlet.2011.09.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Ultra-violet irradiation induces apoptosis via mitochondrial pathway in pancreatic cancer cells.2011
- Author(s)
  Yamauchi T, Adachi S, Yasuda I, Nakashima M, Kawaguchi J, Yoshioka T, Hirose Y, Kozawa O, Moriwaki H.
- Journal Title
  
  Int J Oncol
  
  Volume: 39 Pages: 1375-1380
- NAID
  120006341977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor.2011
- Author(s)
  Adachi S, Yasuda I, Nakashima M, Yamauchi T, Kawaguchi J, Shimizu M, Itani M, Nakamura M, Nishii Y, Yoshioka T, Hirose Y, Okano Y, Moriwaki H and Kozawa O.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286巻 Issue: 29 Pages: 26178-26187
- DOI
  10.1074/jbc.m111.240630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells2011
- Author(s)
  Nakashima M, Adachi S, Yasuda I, Kozawa O, et al.
- Journal Title
  
  Cancer Lett
  
  Volume: 313 Pages: 218-225
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] Ultraviolet enhances the sensitivity of pancreatic cancer cells to gemcitabine by activation of 5' AMP-activated protein kinase2011
- Author(s)
  Adachi S, Yasuda I, Kozawa O, et al.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 414 Pages: 53-59
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] Ultraviolet enhances the sensitivity of pancreatic cancer cells to gemcitabine byactivation of 5' AMP-activated protein kinase.2011
- Author(s)
  Adachi S, Yasuda I, Kawaguchi J, Yamauchi T, Nakashima M, Itani M, Nakamura M, Yoshioka T, Moriwaki H and Kozawa O.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 414巻 Issue: 1 Pages: 53-59
- DOI
  10.1016/j.bbrc.2011.09.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor.2011
- Author(s)
  Adachi S, Yasuda I, Nakashima M, Yamauchi T, Kawaguchi J, Shimizu M, Itani M, Nakamura M, Nishii Y, Yoshioka T, Hirose Y, Okano Y, Moriwaki H, Kozawa O.
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 26178-26187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591013
[Journal Article] Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells2011
- Author(s)
  Tanabe K, Kozawa O, Iida H
- Journal Title
  
  J Neuroinflammation
  
  Volume: 8 Pages: 68-68
- NAID
  120006341957
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592248
[Journal Article] Mechanism of collagen-induced release of 5-HT, PDGF-AB and sCD40L from human platelets : role of HSP27 phosphorylation via p44/p42 MAPK.2010
- Author(s)
  Kato H, Adachi S, Doi T, Matsushima-Nishiwaki R, Minamitani C, Akamatsu S, Enomoto Y, Tokuda H, Otsuka T, Iwama T, Kozawa O, Ogura S.
- Journal Title
  
  Thromb.Res. 126
  
  Pages: 39-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591825
[Journal Article] Mechanisms of tumor necrosis factor-α-induced interleukin-6 synthesis in glioma cells.2010
- Author(s)
  Tanabe K, Matsushima-Nishiwaki R, Yamaguchi S, Iida H, Dohi S, Kozawa O
- Journal Title
  
  J Neuroinflammation 7
  
  Pages: 16-16
- NAID
  120006341942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591798
[Journal Article] Thromboxane A_2 promotes soluble CD40 ligand release from human platelets.2010
- Author(s)
  Enomoto Y, Adachi S, Matsushima-Nishiwaki R, Doi T, Niwa M, Akamatsu S, Tokuda H, Ogura S, Yoshimura S, Iwama T, Kozawa O.
- Journal Title
  
  Atherosclerosis 209
  
  Pages: 415-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Antithrombin III reduces collagen-stimulated granule secretion of PDGF-AB and the release of soluble CD40 ligand from human platelets.2010
- Author(s)
  Doi T, Adachi S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Natsume H, Kato K, Mizutani J, Otsuka T, Tokuda H, Akamatsu S, Iwama T, Kozawa O, Ogura S.
- Journal Title
  
  Int.J.Mol.Med. 26
  
  Pages: 387-392
- NAID
  120006341935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Rho-kinase regulates prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts.2010
- Author(s)
  Kato K, Tokuda H, Natsume H, Adachi S, Matsushima-Nishiwaki R, Minamitani C, Mizutani J, Kozawa O and Otsuka T.
- Journal Title
  
  Exp. Ther. Med.
  
  Volume: 1巻 Pages: 579-583
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/22993579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Antithrombin III reduces collagen-stimulated granule secretion of PDGF-AB and the release of soluble CD40 ligand from human platelets.2010
- Author(s)
  Doi T, Adachi S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Natsume H, Kato K, Mizutani J, Otsuka T, Tokuda H, Akamatsu S, Iwama T, Kozawa O, Ogura S.
- Journal Title
  
  Int.J.Mol.Med. 26
  
  Pages: 387-392
- NAID
  120006341935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591825
[Journal Article] Mechanism of collagen-induced release of 5-HT, PDGF-AB and sCD4OL from human platelets : role of HSP27 phosphorylation via p44/p42 MAPK.2010
- Author(s)
  Kato H, Adachi S, Doi T, Matsushima-Nishiwaki R, Minamitani C, Akamatsu S, Enomoto Y, Tokuda H, Otsuka T, Iwama T, Kozawa O, Ogura S.
- Journal Title
  
  Thromb.Res. 126
  
  Pages: 39-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Raloxifene enhances spontaneous microaggregation of platelets through up-regulation of p44/p42 MAP kinase : a case report.2010
- Author(s)
  Tokuda H, Harada A, Adachi S, Matsushima-Nishiwaki R, Natsume H, Minamitani C, Mizutani J, Otsuka T, Kozawa O.
- Journal Title
  
  Osteoporosis Int. 21
  
  Pages: 189-193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Mechanism of collagen-induced release of 5-HT, PDGF-AB and sCD40L from human platelets: role of HSP27 phosphorylation via p44/p42 MAPK.2010
- Author(s)
  Kato H, Adachi S, Doi T, Matsushima-Nishiwaki R, Minamitani C,Akamatsu S, Enomoto Y, Tokuda H,OtsukaT, Iwama T, Kozawa O and Ogura S.
- Journal Title
  
  Thromb. Res.
  
  Volume: 12巻 Issue: 1 Pages: 39-43
- DOI
  10.1016/j.thromres.2009.12.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] HSP90 inhibitors induce down-regulation of EGF receptor via p38 MAPK-mediated phosphorylation at Ser1046/7 in human pancreatic cancer cells.2010
- Author(s)
  Adachi S, Yasuda I, Natsume H, Nakashima M, Moriwaki H and Kozawa O.
- Journal Title
  
  Oncol. Rep.
  
  Volume: 23巻 Pages: 1709-1714
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/?term=kozawa+HSP90+2010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Phosphorylation status of heat shock protein 27 regulates the interleukin-1β-induced interleukin-6 synthesis in C6 glioma cells.2010
- Author(s)
  Tanabe K, Matsushima-Nishiwaki R, Dohi S, Kozawa O
- Journal Title
  
  Neuroscience 170
  
  Pages: 1028-1034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591798
[Journal Article] Thromboxane A_2 promotes soluble CD40 ligand release from human platelets.2010
- Author(s)
  Enomoto Y, Adachi S, Matsushima-Nishiwaki R, Doi T, Niwa M, Akamatsu S, Tokuda H, Ogura S, Yoshimura S, Iwama T, Kozawa O.
- Journal Title
  
  Atherosclerosis 209
  
  Pages: 415-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591825
[Journal Article] Evaluation for clinicalutility of glypican-3 (GPC3), measured by a commercially available ELISA kit with GPC3 antibody,as aserological andhistological marker forhepatocellular carcinoma.2010
- Author(s)
  Yasuda E, Kumada T, Toyoda H, Kaneoka Y, Maeda A, Okuda S, YoshimiN and Kozawa O.
- Journal Title
  
  Hepatol. Res.
  
  Volume: 40巻 Issue: 5 Pages: 477-485
- DOI
  10.1111/j.1872-034x.2010.00624.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Antithrombin III reduces collagen-stimulated granule secretion of PDGF-AB and the release of soluble CD40 ligand from human platelets.2010
- Author(s)
  Doi T, Adachi S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Natsume H, Kato K, Mizutani J, Otsuka T, Tokuda H, Akamatsu S, Iwama T, Kozawa O and Ogura S.
- Journal Title
  
  Int. J. Mol. Med.
  
  Volume: 26巻 Pages: 387-392
- NAID
  120006341935
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/20664955
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Phosphorylation status of heat shock protein 27 regulates the interleukin-1β-induced interleukin-6 synthesis in C6 glioma cells.2010
- Author(s)
  Tanabe K, Matsushima-Nishiwaki R,Dohi S and Kozawa O.
- Journal Title
  
  Neuroscience.
  
  Volume: 170巻 Issue: 4 Pages: 1028-1034
- DOI
  10.1016/j.neuroscience.2010.08.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590726
[Journal Article] Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts2009
- Author(s)
  Minamitani C, Otsuka T, Takai S, Matsushima Nishiwaki R, Adachi S, Hanai Y, Mizutani J, Tokuda H, Kozawa O.
- Journal Title
  
  Int. J. Mol. Med. 24
  
  Pages: 77-82
- NAID
  120006340793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] αB-crystallin extracellularly suppresses ADP-induced granule secretion from human platelets.2009
- Author(s)
  Enomoto Y, Adachi S, Matsushima-Nishiwaki R, Niwa M, Tokuda H, Akamatsu S, Doi T, Kato H, Yoshimura S, Ogura S, Iwama T, Kozawa O.
- Journal Title
  
  FEBS Lett. 583
  
  Pages: 2464-2468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591825
[Journal Article] Antithrombin III suppresses ADP-induced platelet granule secretion : inhibition of HSP27 phosphorylation.2009
- Author(s)
  Doi T, Adachi S, Takai S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Minamitani C, Otsuka T, Tokuda H, Akamatsu S, Iwama T, Kozawa O, Ogura S.
- Journal Title
  
  Arch.Biochem.Biophys. 489
  
  Pages: 62-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591825
[Journal Article] Mechanisms of interleukin-1β-induced GDNF release from rat glioma cells.2009
- Author(s)
  Tanabe K, Nishimura K, Dohi S, Kozawa O
- Journal Title
  
  Brain Res. 1274
  
  Pages: 11-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591798
[Journal Article] αB-crystallin extracellularly suppresses ADP-induced granule secretion from human platelets.2009
- Author(s)
  Enomoto Y, Adachi S, Matsushima-Nishiwaki R, Niwa M, Tokuda H, Akamatsu S, Doi T, Kato H, Yoshimura S, Ogura S, Iwama T, Kozawa O.
- Journal Title
  
  FEBS Lett. 583
  
  Pages: 2464-2468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Rho-kinase inhibitors decrease TGF-β-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts2009
- Author(s)
  Kuno M, Takai S, Matsushima-Nishiwaki R, Minamitani C, Mizutani J, Otsuka T, Harada A, Adachi S, Kozawa O, Tokuda H.
- Journal Title
  
  Bicohem. Pharmacol 77
  
  Pages: 196-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Level of collagen-induced p38 MAP kinase activation is a biomarker of platelet hyper-aggregation in patients with diabetes mellitus.2009
- Author(s)
  Hanai Y, Adachi S, Yasuda I, Takai S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Akamatsu S, Sakakibara S, Ogura S, Iwama T, Kozawa O, Tokuda H.
- Journal Title
  
  Life Sci. 85
  
  Pages: 386-394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591825
[Journal Article] Level of collagen-induced p38 MAP kinase activation is a biomarker of platelet hyper-aggregation in patients with diabetes mellitus.2009
- Author(s)
  Hanai Y, Adachi S, Yasuda I, Takai S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Akamatsu S, Sakakibara S, Ogura S, Iwama T, Kozawa O, Tokuda H.
- Journal Title
  
  Life Sci. 85
  
  Pages: 386-394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts2009
- Author(s)
  Yamauchi J, Takai S, Matsushima-Nishiwaki R, Adachi S, Minamitani C, Natsume H, Mizutani J, Otsuka T, Takeda J, Harada A, Kozawa O, Tokuda H.
- Journal Title
  
  Int. J. Mol. Med. 23
  
  Pages: 267-272
- NAID
  120006340794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Involvement of Rho-kinase in tumor necrosis factor-α-induced interleukin-6 release from C6 glioma cells.2009
- Author(s)
  Yamaguchi S, Tanabe K, Takai S, Matsushima-Nishiwaki R, Adachi S, Iida H, Kozawa O, Dohi S
- Journal Title
  
  Neurochem Int. 55
  
  Pages: 438-445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591798
[Journal Article] Antithrombin III suppresses ADP-induced platelet granule secretion : inhibition of HSP27 phosphorylation.2009
- Author(s)
  Doi T, Adachi S, Takai S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Minamitani C, Otsuka T, Tokuda H, Akamatsu S, Iwama T, Kozawa O, Ogura S.
- Journal Title
  
  Arch.Biochem.Biophys. 489
  
  Pages: 62-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] Function of Rho-kinase in prostaglandin D_2-induced interleukin-6 synthesis in osteoblasts2008
- Author(s)
  Tokuda H, Takai S, Matsushima-Nishiwaki R, Hanai Y, Adachi S, Minamitani C, Mizutani J, Otsuka T, Kozawa O
- Journal Title
  
  Prostaglandins Leukot. Essent. Fatty Acids 79
  
  Pages: 41-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] (-)-Epigallocatechin gallate reduces transforming growth factor β-stimulated HSP27 induction through the suppression of stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.2008
- Author(s)
  Hayashi K, Kozawa O, et. al.
- Journal Title
  
  Life Sci. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] (-)-Epigallocatechin gallate reduces platelet-derived growth factor BB-stimulated interleukin-6 synthesis in osteoblasts : suppression of SAPK/JNK2008
- Author(s)
  Takai S, Matsushima-Nishiwaki R, Adachi S, Natsume H, Minamitani C, Mizutani J, Otsuka T, Tokuda H, Kozawa O
- Journal Title
  
  Mediators Inflamm 2008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] (-)-Epigallocatechin gallate inhibits basic fibroblast growth factor induced interleukin-6 synthesis in osteoblasts2008
- Author(s)
  Tokuda H, Takai S, Hanai Y, Matsushima-Nishiwaki R, Yamauchi J, Harada A, Hosoi T, Ohta T, Kozawa O.
- Journal Title
  
  Horm. Metab. Res. 40
  
  Pages: 674-678
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] α_2 Adrenoreceptor agonist regulates protein kinase C-induced heat shock protein 27 phosphorylation in C6 glioma cells.2008
- Author(s)
  Tanabe K, Takai S, Matsushima-Nishiwaki R, Kato K, Dohi S, Kozawa O
- Journal Title
  
  J Neurochem. 106
  
  Pages: 519-528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591798
[Journal Article] A case of raloxifene-induced acceleration of platelet aggregation2008
- Author(s)
  Minamitani C, Takai S, Matsushima-Nishiwaki R, Hanai Y, Otsuka T, Kozawa O, Tokuda H.
- Journal Title
  
  Internal Med. 47
  
  Pages: 1523-1528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Involvement of Rho-kinase in prostaglandin F2α stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts2008
- Author(s)
  Minamitani C, Otsuka T, Takai S, Matsushima Nishiwaki R, Adachi S, Hanai Y, Mizutani J, Tokuda H, Kozawa O.
- Journal Title
  
  Mol. Cell. Endocrinol 291
  
  Pages: 27-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion.2008
- Author(s)
  Kato H, Takai S, Matsushima-Nishiwaki R, Adachi S, Minamitani C, Otsuka T, Tokuda H, Akamatsu S, Doi T, Ogura S, Kozawa O.
- Journal Title
  
  Arch.Biochem.Biophys. 475
  
  Pages: 80-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591825
[Journal Article] Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts2008
- Author(s)
  Tokuda H, Takai S, Hanai Y, Harada A, Matsushima Nishiwaki R, Kato H, Ogura S, Kozawa O.
- Journal Title
  
  J. Bone Miner. Metab. 26
  
  Pages: 335-341
- NAID
  10024458639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] A case of raloxifene-induced acceleration of platelet aggregation.2008
- Author(s)
  Minamitani C, Takai S, Matsushima-Nishiwaki R, Hanai Y, Otsuka T, Kozawa O, Tokuda H.
- Journal Title
  
  Internal Med. 47
  
  Pages: 1523-1528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion.2008
- Author(s)
  Kato H, Takai S, Matsushima-Nishiwaki R, Adachi S, Minamitani C, Otsuka T, Tokuda H, Akamatsu S, Doi T, Ogura S, Kozawa O.
- Journal Title
  
  Arch.Biochem.Biophys. 475
  
  Pages: 80-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] p70 S6 kinase negatively regulates FGF-2-stimulated IL-6 synthesis in osteoblasts: function at a point downstream from protein kinase C2008
- Author(s)
  Takai S, Hanai Y, Matushima-Nishiwaki R, Minamitani C, Otsuka T, Tokuda H, Kozawa O.
- Journal Title
  
  J. Endocrinol 197
  
  Pages: 131-137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] (-)-Epigallocatechin gallate reduces transforming growth factor β stimulated HSP27 induction through the suppression of stress activated protein kinase/c-Jun N-terminal kinase in osteoblasts2008
- Author(s)
  Hayashi K, Takai S, Matsushima-Nishiwaki R, Hanai Y, Kato K, Tokuda H, Kozawa O.
- Journal Title
  
  Life Sci. 82
  
  Pages: 1012-1017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] (-)-Epigallocatechin gallate inhibits prostaglandin D_2-stimulated HSP27 induction via suppression of the p44/p42 MAP kinase pathway in osteoblasts2007
- Author(s)
  Yamauchi J, Takai S, Matsushima-Nishiwaki R, Hanai Y, Doi T, Kato H, Ogura S, Kato K, Tokuda H, Kozawa O.
- Journal Title
  
  Prostaglandins Leukot. Essent. Fatty Acids 77
  
  Pages: 173-179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] (-)-Epigallocatechin gallate inhibits prostaglandin D_2-stimulated HSP27 induction via suppression of the p44/p42 MAP kinase pathway in osteoblasts.2007
- Author(s)
  Yamauchi J, Kozawa O, et. al.
- Journal Title
  
  Prostaglandins Leukot. Essent. Fatty Acids 77
  
  Pages: 173-179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Platelet-derived growth factor-BB amplifies PGF_<2α>-induced VEGF synthesis in osteoblasts: function of phosphatidylinositol 3-kinase2007
- Author(s)
  Tokuda H, Takai S, Hanai Y, Harada A, Matsushima-Nishiwaki R, Akamatsu S, Ohta T, Kozawa O
- Journal Title
  
  Prostaglandins Leukot. Essent. Fatty Acids. 77
  
  Pages: 187-193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Negative regulation by p70 S6 kinase of FGF-2-stimulated VEGF release through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts2007
- Author(s)
  Takai S, Tokuda H, Hanai Y, Harada A, Yasuda E, Matsushima-Nishiwaki R, Kato H, Ogura S, Ohta T, Kozawa O
- Journal Title
  
  J. Bone Miner. Res. 22
  
  Pages: 337-346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] (-)-Epigallocatechin gallate enhances prostaglandin F_<2α>-induced VEGF synthesis via up-regulating SAPK/JNK activation in osteoblasts2007
- Author(s)
  Tokuda H, Takai S, Matsushima-Nishiwaki R, Akamatsu S, Hanai Y, Hosoi T, Harada A, Ohta T, Kozawa O.
- Journal Title
  
  J. Cell. Biochem 100
  
  Pages: 1146-1153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Activation of phosphatidylinositol 3-kinase/Akt limits FGF-2-induced VEGF release in osteoblasts2007
- Author(s)
  Takai S, Tokuda H, Hanai Y, Kozawa O.
- Journal Title
  
  Mol. Cell. Endocrinol 267
  
  Pages: 46-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] (-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation2007
- Author(s)
  Tokuda H, Takai S, Hanai Y, Matsushima-Nishiwaki R, Hosoi T, Harada A, Ohta T, Kozawa O.
- Journal Title
  
  FEBS Lett. 581
  
  Pages: 1311-1316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Rho-kinase regulates endothelin-1-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts2007
- Author(s)
  Tokuda H, Hanai Y, Matsushima-Nishiwaki R, Yamauchi J, Doi T, Harada A, Takai S, Kozawa O.
- Journal Title
  
  Biochem. Biophys. Res. Commun 362
  
  Pages: 799-804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] Limitation by p70 S6 kinase of PDGF-BB-induced IL-6 synthesis in osteoblast-like MC3T3-E1 cells2007
- Author(s)
  Takai S, Tokuda H, Hanai Y, Kozawa O.
- Journal Title
  
  Metabolism 56
  
  Pages: 476-483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591042
[Journal Article] PPAR-γ ligands up-regulate basic fibroblast growth factor-induced VEGF release through amplifying SAPK/JNK activation in osteoblasts.2005
- Author(s)
  Yasuda E, Tokuda H, Ishisaki A, Kozawa O, et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 236
  
  Pages: 59-66
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] Possible involvement of phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells.2005
- Author(s)
  Suga H, Nakajima K, Shu E, Kanno Y, Hirade K, Ishisaki A, Matsuno H, Tanabe K, Akamatsu S, Kato K, Oiso Y, Kozawa O
- Journal Title
  
  Arch. Biochem. Biophys. 438
  
  Pages: 137-145
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591623
[Journal Article] SAPK/JNK plays a role in transforming growth factor-β-induced VEGF synthesis in osteoblasts.2005
- Author(s)
  Kanno Y, Ishisaki A, Yoshida M, Tokuda H, Kozawa O et al.
- Journal Title
  
  Horm.Meta.Res. 37
  
  Pages: 140-145
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] Midazolam suppresses thrombin-induced heat shock protein 27 phosphorylation through inhibition of p38 mitogen-activated protein kinase in cardiac myocytes.2005
- Author(s)
  Tanabe K, Akamatsu S, Suga H, Takai S, Kato K, Dohi S, Kozawa O
- Journal Title
  
  J. Cell. Biochem. 96
  
  Pages: 56-64
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591623
[Journal Article] Adenylyl cyclase-cAMP system inhibits thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.2005
- Author(s)
  Kanno Y, Ishisaki A, Yoshida M, Tokuda H, Kozawa O, et al.
- Journal Title
  
  Mol. Cell. Endocrinol. 229
  
  Pages: 75-82
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] Possible involvement of phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells.2005
- Author(s)
  Suga H, Nakajima K, Shu E, Kanno Y, Hirade K, Ishisaki A, Matsuno H, Tanabe K, Akamatsu S, Kato K, Oiso Y, Kozawa O
- Journal Title
  
  Arch. Biochem. Biophys 438
  
  Pages: 137-145
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591623
[Journal Article] SAPK/JNK plays a role in transforming growth factor-β-induced VEGF synthesis in osteoblasts.2005
- Author(s)
  Kanno Y, Ishisaki A, Yoshida M, Tokuda H, Kozawa O, et al.
- Journal Title
  
  Horm. Meta. Res. 37
  
  Pages: 140-145
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] PPAR-γ ligands up-regulate basic fibroblast growth factor-induced VEGF release through amplifying SAPK/JNK activation in osteoblasts.2005
- Author(s)
  Yasuda E, Tokuda H, Ishisaki A, Kozawa O et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 328
  
  Pages: 137-143
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] αB-crystallin is phosphorylated during myocardial infarction : involvement of platelet-derived growth factor-BB.2005
- Author(s)
  Shu E, Matsuno H, Akamatsu S, Kanno Y, Suga H, Nakajima K, Ishisaki A, Kato K, Kitajima Y, Kozawa O
- Journal Title
  
  Arch. Biochem. Biophys. 438
  
  Pages: 111-118
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591623
[Journal Article] Methotrexate suppresses inflammatory agonists-induced interleukin-6 synthesis in osteoblasts.2005
- Author(s)
  Yoshida M, Ishisaki A, Tokuda H, Shimizu K, Kozawa O, et al.
- Journal Title
  
  J. Rheumatology 32
  
  Pages: 787-795
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] Methotrexate suppresses inflammatory agonists-induced interleukin-6 synthesis in osteoblasts.2005
- Author(s)
  Yoshida M, Ishisaki A, Tokuda H, Shimizu K, Kozawa O et al.
- Journal Title
  
  J.Rheumatology 32
  
  Pages: 787-795
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] PPAR-γ ligands up-regulate basic fibroblast growth factor-induced VEGF release through amplifying SAPK/JNK activation in osteoblasts.2005
- Author(s)
  Yasuda E, Tokuda H, Ishisaki A, Hirade K, Kanno Y, Hanai Y, Nakamura N, Noda T, Katagiri Y, Kozawa O
- Journal Title
  
  Biochem.Biophys Res.Commun. 328
  
  Pages: 137-143
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] Methotrexate suppresses inflammatory agonists-induced interleukin-6 synthesis in osteoblasts.2005
- Author(s)
  Yoshida M, Kanno Y, Ishisaki A, Tokuda H, Hirade K, Nakajima K, Katagiri Y, Shimizu K, Kozawa O.
- Journal Title
  
  J.Rheumatology 32
  
  Pages: 787-795
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] Tiludronate inhibits prostaglandin F_<2α>-induced vascular endothelial growth factor synthesis in osteoblasts.2005
- Author(s)
  Yoshida M, Tokuda H, Ishisaki A, Shimizu K, Kozawa O et al.
- Journal Title
  
  Mol.Cell.Endocrinol. 236
  
  Pages: 59-66
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] Adenylyl cyclase-cAMP system inhibits thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.2005
- Author(s)
  Kanno Y, Ishisaki A, Yoshida M, Tokuda H, Kozawa O et al.
- Journal Title
  
  Mol.Cell Endocrinol. 229
  
  Pages: 75-82
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] SAPK/JNK plays a role in transforming growth factor-β-induced VEGF synthesis in osteoblasts.2005
- Author(s)
  Kanno Y, Ishisaki A, Yoshida M, Tokuda H, Numata O, Kozawa O.
- Journal Title
  
  Horm.Metab.Res. 37
  
  Pages: 140-145
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] Tiludronate inhibits prostaglandin F_<2α>-induced vascular endothelial growth factor synthesis in osteoblasts.2005
- Author(s)
  Yoshida M, Tokuda H, Ishisaki A, Kanno Y, Harada A, Shimizu K, Kozawa O
- Journal Title
  
  Mol.Cell.Endocrinol. 236
  
  Pages: 59-66
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] Tiludronate inhibits prostaglandin F_<2α>-induced vascular endothelial growth factor synthesis in osteoblasts.2005
- Author(s)
  Yoshida M, Tokuda H, Ishisaki A, Shimizu K, Kozawa O, et al.
- Journal Title
  
  Mol. Cell. Endocrinol. 236
  
  Pages: 59-66
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] αB-crystallin is phosphorylated during myocardial infarction : involvement of platelet-derived growth factor-BB.2005
- Author(s)
  Shu E, Matsuno H, Akamatsu S, Kanno Y, Suga H, Nakajima K, Ishisaki A, Kato K, Kitajima Y, Kozawa O
- Journal Title
  
  Arch.Biochem.Biophys. 438
  
  Pages: 111-118
- Data Source
  KAKENHI-PROJECT-17591623
[Journal Article] Adenylyl cyclase-cAMP system inhibits thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.2005
- Author(s)
  Kanno Y, Ishisaki A, Yoshida M, Nakajima K, Tokuda H, Numata O, Kozawa O.
- Journal Title
  
  Mol.Cell.Endocrinol. 229
  
  Pages: 75-82
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590873
[Journal Article] Effect of a synthetic matrix metalloproteinase inhibitor (ONO-4817) on neointima formation in hypercholesterolemic hamsters.2004
- Author(s)
  Matsuno H, Ishisaki A, Nakajima K, Kozawa O.
- Journal Title
  
  J Cardiovasc Pharmacol. 44
  
  Pages: 57-65
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590223
[Journal Article] A peptide isolated from alpha B-crystallin is a novel and potent inhibitor of platelet aggregation via dual prevention of PAR-1 and GPIb/V/IX.2003
- Author(s)
  Matsuno H, Ishisaki A, Nakajima K, Kato K, Kozawa O.
- Journal Title
  
  J.Thromb Haemost. 1
  
  Pages: 2636-2642
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590223
[Journal Article] Simvastatin enhances the regeneration of endothelial cells via VEGF secretion in injured arteries.2003
- Author(s)
  Matsuno H, Takei M, Hayashi H, Nakajima K, Ishisaki A, Kozawa O.
- Journal Title
  
  J Cardiovasc Pharmacol. 43
  
  Pages: 333-340
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590223
[Journal Article] Alpha2-antiplasmin plays a significant role in acute pulmonary embolism.2003
- Author(s)
  Matsuno H, Okada K, Ueshima S, Matsuo O, Kozawa O
- Journal Title
  
  J Thromb Haemost. 1
  
  Pages: 1734-1739
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590223
[Journal Article] A peptide isolated from alpha B-crystallin is a novel and potent inhibitor of platelet aggregation via dual prevention of PAR-1 and GPIb/V/IX.2003
- Author(s)
  Matsuno H, Ishisaki A, Nakajima K, Kato K, Kozawa O.
- Journal Title
  
  J Thromb Haemost. 1
  
  Pages: 2636-2642
- Data Source
  KAKENHI-PROJECT-15590223
[Journal Article] cAMP regulates ADP-induced HSP27 phosphorylation in human platelets.
- Author(s)
  Enomoto Y, Adachi S, Doi T, Natsume H, Kato K, Matsushima-Nishiwaki R, Akamatsu S, Tokuda H, Yoshimura S, Otsuka T, Ogura S, Kozawa O, Iwama T.
- Journal Title
  
  Int.J.Mol.Med. in press
- NAID
  120006341953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591825
[Journal Article] cAMP regulates ADP-induced HSP27 phosphorylation in human platelets.
- Author(s)
  Enomoto Y, Adachi S, Doi T, Natsume H, Kato K, Matsushima-Nishiwaki R, Akamatsu S, Tokuda H, Yoshimura S, Otsuka T, Ogura S, Kozawa O, Iwama T.
- Journal Title
  
  Int.J.Mol.Med. in press
- NAID
  120006341953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590565
[Journal Article] (-)-Epigallocatechin gallate selectively inhibits ADP-stimulated human platelet activation : suppression of HSP27 phosphorylation via p38 MAP kinase
- Author(s)
  Iida Y, Doi T, Matsushima-Nishiwaki R, Tokuda H, Ogura S, Kozawa O and Iida H
- Journal Title
  
  Mol. Med. Rep.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592249
[Presentation] GLP-1 reduces the migration of hepatocellular carcinoma cells via suppression of the c-Jun N-terminal kinase pathway2021
- Author(s)
  Rie Matsushima-Nishiwaki, Noriko Yamada, Osamu Kozawa
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08283
[Presentation] ケルセチンは、HGFまたはTGF-αによって刺激されたHCC細胞遊走を抑制する：AKTシグナル伝達経路の減衰2020
- Author(s)
  山田紀子、西脇　理英、小澤　修
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08283
[Presentation] HSP90 inhibitor enhances PGD2-stimulated HSP27 induction in osteoblasts.2019
- Author(s)
  Kim W, Nakashima D, Tachi J, Tanabe K, Kozawa O, Iida H.
- Organizer
  American Soceity of Anesthesiologists 2019 Annual Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09370
[Presentation] Smoking cessation enhances platelet aggregation via the release of HSP27 from human platelets stimulated by collagen.2019
- Author(s)
  Onuma T, Kito Y, Iida M, Tanabe K, Kozawa O, Iida H.
- Organizer
  Euroanaesthesia 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09370
[Presentation] HSP90 inhibitors strengthen extracellular ATP-stimulated synthesis of interleukin-6 in osteoblasts: amplification of p38 MAP kinase.2019
- Author(s)
  Nakashima D, Kin W, Tachi J, Tanabe K, Kozawa O, Iida H.
- Organizer
  American Soceity of Anesthesiologists 2019 Annual Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09370
[Presentation] ResveratrolはSAPK/JNKおよびAktを阻害しepidermal growth factor (EGF) による骨芽細胞の遊走を抑制する2018
- Author(s)
  川端　哲、徳田治彦、藤田和彦、酒井　剛、大塚聖視、小澤　修、大塚隆信
- Organizer
  第20回日本骨粗鬆症学会
- Data Source
  KAKENHI-PROJECT-17K11002
[Presentation] 骨芽細胞においてストレス蛋白質(HSP)90阻害剤はプロスタグランジンF2α(PGF)F2αによるインターロイキン(IL)-6産生を増強する－p38 mitogen-activated protein kinase(MAPK) 経路の関与－2018
- Author(s)
  徳田治彦、藤田和彦、原田　敦、新飯田俊平、小澤　修
- Organizer
  第60回日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11002
[Presentation] HSP22はPI3K/AKT経路を阻害し肝癌細胞の遊走を抑制する2018
- Author(s)
  西脇理英、吉見直己、小澤　修
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09350
[Presentation] 骨芽細胞においてHSP90の阻害剤はPGF2αによるインターロイキン(IL)-6の産生を促進する2018
- Author(s)
  藤田和彦、徳田治彦、川端　哲、酒井　剛、小澤　修
- Organizer
  第20回日本骨粗鬆症学会
- Data Source
  KAKENHI-PROJECT-17K11002
[Presentation] 骨芽細胞においてHSP70はTGF-βによるVEGF産生をp38 MAP Kinaseを介して抑制的に制御する2018
- Author(s)
  酒井　剛、徳田治彦、藤田和彦、川端　哲、小澤　修
- Organizer
  第20回日本骨粗鬆症学会
- Data Source
  KAKENHI-PROJECT-17K11002
[Presentation] 骨芽細胞においてHSP22はTNF-αによるIL-6産生をmTORを介して抑制する2018
- Author(s)
  酒井　剛、徳田治彦、小澤　修
- Organizer
  第91回日本生化学会
- Data Source
  KAKENHI-PROJECT-17K11002
[Presentation] Sphigosine-1-phosphate suppresses collagen-induced human platelet activation.2016
- Author(s)
  Onuma T, Tanabe K, Kozawa O, Iida H.
- Organizer
  Anesthesiology 2016 Annual Meeting
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-26462335
[Presentation] Phosphorylated HSP20 (HSPB8) regulates TNF-α-induced migration and invasion of hepatocellular carcinoma cells. TNF-α刺激による肝癌細胞遊走および浸潤のリン酸化HSP20 (HSPB8) による抑制2016
- Author(s)
  西脇理英、豊田秀徳、熊田　卓、小澤　修
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K09350
[Presentation] 血小板の炎症誘導作用におけるRacの役割2016
- Author(s)
  土井智章、陰山康成、小澤　修、小倉真治
- Organizer
  第31回日本Shock学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-26462335
[Presentation] The role of Rac in human platelets: An analysis of the molecular mechanism underlying Rac-effects on the activation2016
- Author(s)
  Doi Tomoaki、Kozawa Osamu、Kageyama Yasunari、Ogura Shinji
- Organizer
  Thirty-eight Annual Conference on Shock
- Place of Presentation
  Denver, USA
- Year and Date
  2016-06-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462335
[Presentation] 脳の中のheat shock protein2015
- Author(s)
  田辺久美子、小澤　修、飯田宏樹
- Organizer
  日本麻酔科学会第62回学術集会
- Place of Presentation
  神戸
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-26462334
[Presentation] 血小板機能におけるRacの役割：抗炎症作用の分子機序解析2014
- Author(s)
  土井智章、陰山康成、小澤　修、小倉真治
- Organizer
  第29回日本Shock学会
- Place of Presentation
  松山
- Year and Date
  2014-05-17
- Data Source
  KAKENHI-PROJECT-26462335
[Presentation] 骨芽細胞においてPho-kinaseはthyroid hormoneによるosteocalcin産生を抑制的に制御する2013
- Author(s)
  近藤章、加藤賢治、黒柳元、山本尚洋、水谷潤、徳田治彦、小澤修、大塚隆信
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張メッセ国際会議場(千葉)
- Data Source
  KAKENHI-PROJECT-24592273
[Presentation] 骨芽細胞においてカテキンはinterleulin-1(IL-1)によるIL-6生産を促進的に制御している2013
- Author(s)
  黒柳元、近藤章、水谷潤、西脇理英、徳田治彦、小澤修、大塚隆信
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張メッセ国際会議場(千葉)
- Data Source
  KAKENHI-PROJECT-24592273
[Presentation] アンチトロンビンIIIの血小板に対する抗炎症作用の基礎的解析2013
- Author(s)
  土井智章、小澤修、加藤久晶、小倉真治
- Organizer
  第40回日本集中治療医学会学術集会
- Place of Presentation
  松本
- Year and Date
  2013-02-28
- Data Source
  KAKENHI-PROJECT-23592249
[Presentation] 肝がんとｽﾄﾚｽ蛋白質（HSP:Heat Shock Protein):特に低分子量HSPとの関連において2013
- Author(s)
  小澤　修
- Organizer
  第7回日本肝がん分子標的治療研究会
- Place of Presentation
  岐阜県岐阜市じゅうろくプラザ
- Invited
- Data Source
  KAKENHI-PROJECT-22590726
[Presentation] Analysis of the anti-inflammatory effects of antithrombin III on human blood2013
- Author(s)
  Doi T, Kozawa O, Ogura S
- Organizer
  Thirty-Sixth Annual Conference on Shock
- Place of Presentation
  San Diego、USA
- Year and Date
  2013-06-04
- Data Source
  KAKENHI-PROJECT-23592249
[Presentation] 骨芽細胞においてSAPK/JNKはinterleukin-1によるinterleukin-6生産を抑制的に制御している2013
- Author(s)
  山本尚洋、加藤賢治、近藤章、黒柳元、水谷潤、徳田治彦、小澤修、大塚隆信
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張メッセ国際会議場(千葉)
- Data Source
  KAKENHI-PROJECT-24592273
[Presentation] 肝がんとストレス蛋白質(HSP:HeatShockProtein):特に低分子量 HSP との関連において2013
- Author(s)
  小澤修
- Organizer
  第7回日本肝がん分子標的治療研究会教育講演
- Place of Presentation
  岐阜
- Year and Date
  2013-01-19
- Data Source
  KAKENHI-PROJECT-22590726
[Presentation] Analysis of the anti-inflammatory effects of antithrombin III on human blood2013
- Author(s)
  Doi T、Kozawa O、Ogura S
- Organizer
  Thirty-sixth Annual Conference on Shock
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23592249
[Presentation] アンチトロンビンIIIの血小板に対する抗炎症作用の基礎的解析2012
- Author(s)
  土井智章、小澤修、小倉真治
- Organizer
  第40回日本救急医学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2012-11-13
- Data Source
  KAKENHI-PROJECT-23592249
[Presentation] ゲムシタビン作用機序における HSP27 リン酸化の役割2012
- Author(s)
  中島賢憲、足立政治、安田一朗、河口順二、山内貴裕、森脇久隆、小澤修
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-21
- Data Source
  KAKENHI-PROJECT-22590726
[Presentation] Analysis of the anti-inflammatory effects of antithrombin III on human platelets2012
- Author(s)
  Doi T、Kozawa O、Enomoto Y、Ogura S
- Organizer
  Thirty-Fifth Annual Conference on Shock
- Place of Presentation
  Florida,USA
- Year and Date
  2012-06-12
- Data Source
  KAKENHI-PROJECT-23592249
[Presentation] 骨代謝とストレス蛋白質 (HSP) :特に骨芽細胞における低分子量 HSP27 において2012
- Author(s)
  小澤修
- Organizer
  第27回日本整形外科学会基礎学術集会ランチョンセミナー
- Place of Presentation
  名古屋
- Year and Date
  2012-10-27
- Data Source
  KAKENHI-PROJECT-22590726
[Presentation] 膵がん細胞に対する短波長紫外線(UV-C)とゲムシタビン併用による腫瘍増殖抑制およびアポトーシス誘導効果2012
- Author(s)
  山内貴裕、足立政治、安田一朗、小澤修ら
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-19
- Data Source
  KAKENHI-PROJECT-23591013
[Presentation] アンチトロンビンIII (AT-III)の血小板に対する抗炎症作用の解析2012
- Author(s)
  土井智章、小澤修、榎本由貴子、小倉真治
- Organizer
  第39回日本集中治療医学会学術集会
- Place of Presentation
  幕張
- Year and Date
  2012-02-28
- Data Source
  KAKENHI-PROJECT-23592249
[Presentation] ゲムシタビン作用機序におけるHSP27リン酸化の役割2012
- Author(s)
  中島賢憲、足立政治、安田一朗、小澤修ら
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-21
- Data Source
  KAKENHI-PROJECT-23591013
[Presentation] Molecular mechanism of antithrombin III in the anti-inflammatory effects on human platelets2011
- Author(s)
  Doi T, Adachi S, Kato H, Kozawa O, Ogura S
- Organizer
  Thirty-Fourth Annual Conference on Shock
- Place of Presentation
  Norfolk、USA
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-23592249
[Presentation] アンチトロンビン皿の血小板に対する抗炎症作用の解析2011
- Author(s)
  土井智章、小澤修、加藤久晶、足立政治、小倉真治
- Organizer
  第38回日本集中治療医学会学術集会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2011-02-26
- Data Source
  KAKENHI-PROJECT-20590565
[Presentation] アンチトロンビンIIIの血小板に対する抗炎症作用の解析2011
- Author(s)
  土井智章, 小澤修, 加藤久晶, 足立政治, 小倉真治
- Organizer
  第38回日本集中治療医学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2011-02-26
- Data Source
  KAKENHI-PROJECT-20591825
[Presentation] 膵がんの細胞増殖能におけるRho- kinaseの役割2011
- Author(s)
  足立政治、安田一朗、小澤修ら
- Organizer
  第42回日本膵臓学会大会
- Place of Presentation
  弘前
- Year and Date
  2011-07-30
- Data Source
  KAKENHI-PROJECT-23591013
[Presentation] 骨芽細胞における HSP27 によるオステオカルシン産生制御2011
- Author(s)
  加藤賢治、南谷千帆、夏目英雄、近藤章、水谷潤、小澤修、大塚隆信
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  前橋
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-22590726
[Presentation] アンチトロンビンIIIの血小板に対する抗炎症作用の解析2011
- Author(s)
  土井智章、小澤修、加藤久晶、足立政治、小倉真治
- Organizer
  第38回日本集中治療医学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2011-02-24
- Data Source
  KAKENHI-PROJECT-23592249
[Presentation] Heat shock protein 90 inhibitors as a possible new candidate for the treatment of human pancreatic cancer2010
- Author(s)
  Seiji Adachi, Ichiro Yasuda, Masanori Nakashima, Takahiro Yamauchi, Hisataka Moriwaki and Osamu Kozawa.
- Organizer
  2010 国際膵臓学会
- Place of Presentation
  福岡
- Year and Date
  2010-07-11
- Data Source
  KAKENHI-PROJECT-22590726
[Presentation] Analysis of new molecular mechanisms and the anti-inflammatory effects of antithrombin III in human platelets.2010
- Author(s)
  Tomoaki Doi, Seiji Adachi, Hisaaki Kato, Osamu Kozawa, Shinji Ogura
- Organizer
  Thirty-Third Annual Conference on Shock
- Place of Presentation
  Portland, Oregon, U.S.A.
- Year and Date
  2010-06-13
- Data Source
  KAKENHI-PROJECT-20590565
[Presentation] Analysis of new molecular mechanisms and the anti-inflammatory effect s of antithrombin III in human platelets.2010
- Author(s)
  土井智章, 足立政治, 加藤久晶, 小澤修, 小倉真治
- Organizer
  Thirty-Third Annual Conference on Shock.
- Place of Presentation
  Portland, Oregon, U.S.A.
- Year and Date
  2010-06-13
- Data Source
  KAKENHI-PROJECT-20591825
[Presentation] Heat shock protein 90 阻害剤の膵がん治療への応用2010
- Author(s)
  足立政治、安田一朗、中島賢憲、山内貴裕、森脇久隆、小澤修
- Organizer
  第52回日本消化器病学会大会
- Place of Presentation
  横浜
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-22590726
[Presentation] 骨芽細胞における transforming growth factor-β(TGF-β)による heat shock protein 27 (HSP27)誘導に対する Rho-kinase の役割2010
- Author(s)
  南谷千帆、小澤修、徳田治彦、夏目英雄、加藤賢治、水谷潤、福岡宗良、大塚隆信
- Organizer
  第25回日本整形外科学会基礎学術集会
- Place of Presentation
  京都
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-22590726
[Presentation] アンチトロンビンIIIの新たな分子作用機序の解析:抗炎症作用2009
- Author(s)
  土井智章、小澤修、加藤久品、足立政治、小倉真治
- Organizer
  第24回日本shock学会総会
- Place of Presentation
  石川県金沢市
- Year and Date
  2009-05-30
- Data Source
  KAKENHI-PROJECT-20590565
[Presentation] 血小板におけるアンチトロンビンIIIの新たな分子作用機序の解析:抗炎症作用2009
- Author(s)
  土井智章, 小澤修, 加藤久晶, 足立政治, 小倉真治
- Organizer
  第24回日本shock学会総会
- Place of Presentation
  金沢
- Year and Date
  2009-05-30
- Data Source
  KAKENHI-PROJECT-20591825
[Presentation] 血栓形成機序と抗血小板薬の作用機序2008
- Author(s)
  小澤修
- Organizer
  第16回日本集中治療医学会東海北陸地方会
- Place of Presentation
  岐阜
- Year and Date
  2008-07-05
- Data Source
  KAKENHI-PROJECT-20591825
[Presentation] 骨芽細胞においてRho-kinaseはBMP-4によるosteocalcin産生を抑制的に制御している
- Author(s)
  山本尚洋、近藤章、黒柳元、貝沼慎悟、水谷潤、徳田治彦、小澤修、大塚隆信
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  城山観光ホテル（鹿児島）
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24592273
[Presentation] 骨芽細胞においてresveratrolはPGF2αによるosteoprotegerin産生を抑制する
- Author(s)
  貝沼慎悟、黒柳元、近藤章、山本尚洋、水谷潤、徳田治彦、小澤修、大塚隆信
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  城山観光ホテル（鹿児島）
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24592273

1. MATSUNO Hiroyuki (40273148)

# of Collaborated Projects: 8 results

# of Collaborated Products: 5 results
2. UEMATSU Tohihiko (50151832)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. TOKUDA Haruhiko (10397325)

# of Collaborated Projects: 5 results

# of Collaborated Products: 46 results
4. AKAMATSU Shigeru (20167828)

# of Collaborated Projects: 5 results

# of Collaborated Products: 22 results
5. NIWA Masayuki (40156146)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. TANABE Kumiko (30402209)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
7. NISHIWAKI Rie (90734202)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
8. ADACHI Seiji (50467205)

# of Collaborated Projects: 2 results

# of Collaborated Products: 40 results
9. YASUDA Ichiro (00377673)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
10. MIZUTANI Jun (70326156)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
11. OTSUKA Takanobu (10185316)

# of Collaborated Projects: 2 results

# of Collaborated Products: 34 results
12. ISHISAKI Akira (20356439)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
13. NAKAJIMA Keiichi (70362150)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
14. FUKUOKA Muneyoshi (80285204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. OOSAWA Yosuke (60447787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. DOHI Shuji (40155627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. Iida Hiroki (30159561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
18. 高井信治 (60402153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 鈴木伸幸 (50551230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 高井光治 (70402196)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. IIDA Mami

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 西原利治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. 黒柳元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOZAWA Osamu 小澤 修

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Heat shock protein 22 (HSPB8) reduces the migration of hepatocellular carcinoma cells through the suppression of the phosphoinositide 3-kinase (PI3K)/AKT pathwayPrincipal Investigator

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Molecular targets of low-molecular-weight heat shock proteins in hepatocellular carcinoma cell proliferationPrincipal Investigator

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Role of low-molecular-weight heat shock proteins and the molecular mechanism in hepatocellular carcinoma cell proliferationPrincipal Investigator

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KOZAWA Osamu 小澤修