USHIJIMA Toshikazu 牛島俊和

… Alternative Names

Researcher Number	90232818
Other IDs
Affiliation (Current)	2019: 国立研究開発法人国立がん研究センター, 研究所, 分野長
Affiliation (based on the past Project Information) *help	2015 – 2019: 国立研究開発法人国立がん研究センター, 研究所, 分野長 2015: 国立がん研究センター, エピゲノム解析分野, 分野長 2014: 国立がんセンター(研究所及び東病院臨床開発センター), 発がん研究部, 部長 2014: 独立行政法人国立がん研究センター, 研究所 2013 – 2014: 独立行政法人国立がん研究センター, その他部局等, その他 … More
Review Section/Research Field	Principal Investigator Biological Sciences / Tumor biology / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Biological Sciences / Neurosurgery / Urology / Gastroenterology / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator エピジェネティクス / MS-RDA / DNA methylation / 胃がん / Lysyl oxidase / CpGアイランド / DNAメチル化 / メチル化 / Gastric cancers / HRASLS … More Except Principal Investigator LOH / PhIP / 遺伝子変異 / Igf2 / aberrant crypt focus / TmR2 / RLGS / 遺伝子改変マスウ / 乳がん / suppressor / 突然変異スペクトル / 肝発癌 / 肝細胞癌 / 細胞分化 / Brca-1 / Brca-2 / IonTorrent / 発がん感受性 / エピゲノム異常 / 染色体 / データベース / APC / 病理形態学 / differential display / 遺伝子診断 / マウス / 発癌抑制 / 脳腫瘍 / 細胞周期 / oncogene / 相同組換え / 発生・分化 / 微生物学的モニタリング / 凍結保存 / L-1RA / HCV / Ion Torrent / グリオーマ / 連鎖解析 / トランスジェニック / MSMマウス / H.Pylori / DNAメチル化 / carcinogenesis / 骨髄異形成症候群 / 核酸 / mac25 / Apc / 遺伝子改変マウス / 染色体マッピング / 分子分類 / エピゲノム / 遺伝子変化 / coenzyume Q / 造血細胞 / 組織幹細胞 / ゲノム編集 / 発現制御 / ノックアウト / 前立腺 / 膠芽腫 / 遺伝学的モニタリング / PLGS / マイクロアレイ / ヘテロサイクリックアミン / p53 / ゲノム異常 / β-カテニン / iPS / microsatellite / genomic instability / β-catenin / エピジェネティクス / 前立腺発癌 / coenzyme Q / 神経芽腫 / リンパ球 / AID / mouse / コレステロール / 発ガン / TERT / 次世代シークエンス / 遺伝子 / PP2AB / MS-RDA / 発ガン抑制 / CGH / バイオテクノロジー / 遺伝子トラップ / 癌幹細胞 / メチル化 / マウス肝発癌 / 組織診断 / 炎症発癌 Less

iPS発がんモデルとゲノム編集スクリーニングによる神経芽腫エピゲノム療法開発Ongoing
- Principal Investigator
  
  上條岳彦
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Research Institute for Clinical Oncology, Saitama Cancer Center
lnc162によるDNA脱メチル化剤感受性増強の分子機構の解明Principal InvestigatorOngoing
- Principal Investigator
  
  牛島俊和
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Clarification of molecular mechanism of aberrant DNA methylation induction by chronic inflammationPrincipal Investigator
- Principal Investigator
  
  Ushijima Toshikazu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
Identification of novel prognostic markers for glioblastomas by means of next-generation sequencing-ased targeted resequencing
- Principal Investigator
  
  ICHIMURA Koichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  National Cancer Center Japan
  National Center of Neurology and Psychiatry
Global anallysis of genetic and epigenetic alterations during inflammation-associated gastrointestinal cancer development, and elucidation of its mechanism
- Principal Investigator
  
  CHIBA Tsutomu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Control of cell fate decision in the cells differentiating to multiple pathways in a step-by-step fashion
- Principal Investigator
  
  KITAMURA Toshio
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Integrated cancer research using in vivo models
- Principal Investigator
  
  YAMAMURA Kenichi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Identification of tumor suppressor genes in gastric cancers by genome-wide analysis of DNA methylation and its functional analysisPrincipal Investigator
- Principal Investigator
  
  USHIJIMA Toshikazu
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
酸化ストレスによる前立腺発癌の促進作用とその抑制に関する研究
- Principal Investigator
  
  本間之夫
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  The University of Tokyo
Identification of genes silenced in human gastric cancersPrincipal Investigator
- Principal Investigator
  
  USHIJIMA Toshikazu
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center
Abnormalities in maintenance of methylation and carcinogenesis.Principal Investigator
- Principal Investigator
  
  USHIJIMA Toshikazu
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  National Cancer Center Resaerch Institute Carcinogenesis
マウス肝発癌の初期遺伝子変化
- Principal Investigator
  
  小川勝洋
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Asahikawa Medical College
環境発がん物質の遺伝子変異特性
- Principal Investigator
  
  長尾美奈子
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
発がん過程における遺伝子変異
- Principal Investigator
  
  長尾美奈子
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
マウスを中心とする遺伝子レベルの発癌の研究
- Principal Investigator
  
  北川知行
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
ヘテロサイクリックアミン誘発実験動物腫瘍における遺伝子変化
- Principal Investigator
  
  長尾美奈子
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

All 2017 2016 2015 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001

All Journal Article Presentation

[Journal Article] Epigenetic impact of infection on carcinogenesis: mechanisms and applications2016
- Author(s)
  Hattori N, Ushijima T
- Journal Title
  
  Genome Medicine
  
  Volume: 8 Pages: 10-10
- DOI
  10.1186/s13073-016-0267-2
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04302, KAKENHI-PROJECT-15K18420
[Journal Article] Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer2015
- Author(s)
  Yoda Y, Takeshima H, Niwa T, Kim JG, Ando T, Kushima R, Sugiyama T, Katai H, Noshiro H, Ushijima T
- Journal Title
  
  Gastric Cancer
  
  Volume: 18 Pages: 65-76
- DOI
  10.1007/s10120-014-0348-0
- Open Access / Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04302
[Journal Article] Inflammatory processes triggered by H. pylori infection cause aberrant DNA methylation in gastric epithelial cells.2010
- Author(s)
  Niwa T, Tsukamoto T, Toyoda T, Mori A, Tanaka H, Maekita T, Ichinose M, Tatematsu M, Ushijima T.
- Journal Title
  
  Cancer Res 70
  
  Pages: 1430-1440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] RUNX3 expression correlates with chief cell differentiation in human gastric cancers.2009
- Author(s)
  Ogasawara N, Tsukamoto T, Mizoshita T, Inada KI, Ban H, Kondo S, Takasu S, Ushijima T, Ito K, ItoY, Ichinose M, Ogawa T, Joh T, Tatematsu M.
- Journal Title
  
  Histol Histopathol 24
  
  Pages: 31-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] Methylationsensitive representational difference analysis (MS-RDA).2009
- Author(s)
  Ushijima T, Yamashita S.
- Journal Title
  
  Methods Mol Biol 507
  
  Pages: 117-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] RUNX3 expression correlates with chief cell differentiation in human gastric cancers.2009
- Author(s)
  Ogasawara, N., Tsukamoto, T., Mizoshita, T., Inada, KI., Ban, H., Kondo, S., Takasu, S., Ushijima, T., Ito, K., Ito, Y., Ichinose, M., Ogawa, T., Joh, T., and Tatematsu, M.
- Journal Title
  
  Histol Histopathol 24
  
  Pages: 31-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradication.2009
- Author(s)
  Nakajima T, Enomoto S, Yamashita S, Ando T, Nakanishi Y, Nakazawa K, Oda I, Gotoda T, Ushijima T.
- Journal Title
  
  J Gastroenterol 45
  
  Pages: 37-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect.2009
- Author(s)
  Ando T, Yoshida T, Enomoto S, Asada K, Tatematsu M, Ichinose M, Sugiyama T, Ushijima T.
- Journal Title
  
  Int J Cancer 124
  
  Pages: 2367-2374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae.2009
- Author(s)
  Nakajima, T., Yamashita, S., Maekita, T., Niwa, T., Nakazawa, K., and Ushijima, T.
- Journal Title
  
  Int J Cancer 124
  
  Pages: 905-910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae.2009
- Author(s)
  Nakajima T, Yamashita S, Maekita T, Niwa T, Nakazawa K, Ushijima T.
- Journal Title
  
  Int J Cancer 124
  
  Pages: 905-910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] Epigenetic field for cancerization.2007
- Author(s)
  Ushijima T.
- Journal Title
  
  J Biochem Mol Biol 40
  
  Pages: 142-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] Epigenetic field for cancerization.2007
- Author(s)
  Ushijima, T.
- Journal Title
  
  Journal of Biochemistxy and Molecular Biology 40
  
  Pages: 142-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] Cyclin D1 overexpression in N-methyl-N'-nitro-Nnitrosoguanidine- induced rat gastric adenocarcinomas.2007
- Author(s)
  Takasu S, TsukamotoT, Ushijima T, Yamashita S, Ogasawara N, Ban H, Yanai T, Masegi T, Tatematsu M.
- Journal Title
  
  Exp Toxicol Pathol 59
  
  Pages: 171-175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] Epigenetic field for cancerization.2007
- Author(s)
  Ushijima, T.
- Journal Title
  
  Journal of Biochemistry and Molecular Biology 40(2)
  
  Pages: 142-150
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] Lack of association between CpG island methylator phenotype in human gastric cancers and methylation in their background non-cancerous gastric mucosae.2007
- Author(s)
  Enomoto S, Maekita T, Tsukamoto T, Nakajima T, Nakazawa K, Tatematsu M, Ichinose M, Ushijima T.
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1853-1861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] Larger numbers of silenced genes in cancer cell lines with increased de novo methylation of scattered CpG sites.2007
- Author(s)
  Moriguchi K, Yamashita S, Tsujino Y, Tatematsu M, Ushijima T.
- Journal Title
  
  Cancer Lett 249
  
  Pages: 178-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] Genome-wide profiling of promoter methylation in human.2006
- Author(s)
  Hatada I, Fukasawa M, Kimura M, Morita S, Yamada K, Yoshikawa T, Yamanaka S, Endo C, Sakurada A, Sato M, Kondo T, Horii A, Ushijima T, Sasaki H.
- Journal Title
  
  Oncogene 25
  
  Pages: 3059-3064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory.2006
- Author(s)
  Murayama A, Sakura K, Nakama M, Yasuzawa-Tanaka K, Fujita E, Tateishi Y, Wang Y, Ushijima T, Baba T, Shibuya K, Shibuya A, Kawabe Y, Yanagisawa J.
- Journal Title
  
  EMBO J 25
  
  Pages: 1081-1092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.2006
- Author(s)
  Yamashita S, Tsujino Y, Moriguchi K, Tatematsu M, Ushijima T.
- Journal Title
  
  Cancer Sci 97
  
  Pages: 64-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] Decreased fidelity in replicating CpG methylation patterns in cancer cells.2005
- Author(s)
  Ushijima, T.他
- Journal Title
  
  Cancer Res. 65
  
  Pages: 11-17
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] Detection and interpretation of altered methylation in cancer cells.2005
- Author(s)
  Ushijima, T.
- Journal Title
  
  Nat.Reviews Cancer 5
  
  Pages: 223-231
- Data Source
  KAKENHI-PROJECT-12213150
[Journal Article] Decreased fidelity in replicating CpG methylation patterns in cancer cells.2005
- Author(s)
  Ushijima T, Watanabe N, Shimizu K, Miyamoto K, Sugimura T, Kaneda A.
- Journal Title
  
  Cancer Res 65
  
  Pages: 11-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013090
[Journal Article] Decreased expression of the seven ARP2/3 complex genes in human gastric cancers.2004
- Author(s)
  Kaneda, A, Kaminishi, M, Sugimura, T, Ushijima, T.
- Journal Title
  
  Cancer Lett 212
  
  Pages: 203-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213150
[Journal Article] Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation.2004
- Author(s)
  Kaneda, A, Tsukamoto, T, Takamura-Enya, T, Watanabe, N, Kaminishi, M, Sugimura, T, Tatematsu, M, Ushijima, T.
- Journal Title
  
  Cancer Sci 95
  
  Pages: 58-64
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213150
[Journal Article] Focus on gastric cancer.2004
- Author(s)
  Ushijima, T., Sasako, M.
- Journal Title
  
  Cancer Cell 5
  
  Pages: 121-125
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12213150
[Journal Article] Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.2004
- Author(s)
  Kaneda, A, Wakazono, K, Tsukamoto, T, Watanabe, N, Yagi, Y, Tatematsu, M, Kaminishi, M, Sugimura, T, Ushijima, T.
- Journal Title
  
  Cancer Res 64
  
  Pages: 6410-5
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213150
[Journal Article] Focus on gastric cancer.2004
- Author(s)
  Ushijima, T, Sasako, M.
- Journal Title
  
  Cancer Cell 5
  
  Pages: 121-5
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213150
[Journal Article] Methylation-sensitive representational difference analysis and its application to cancer research.2003
- Author(s)
  Kaneda, A, Takai, D, Kaminishi, M, Okochi, E, Ushijima, T.
- Journal Title
  
  Ann N Y Acad Sci 983
  
  Pages: 131-41
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213150
[Journal Article] Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers.2002
- Author(s)
  Kaneda, A, Kaminishi, M, Nakanishi, Y, Sugimura, T, Ushijima, T.
- Journal Title
  
  Int J Cancer 100
  
  Pages: 57-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213150
[Journal Article] Identification of silencing of nine genes in human gastric cancers.2002
- Author(s)
  Kaneda, A, Kaminishi, M, Yanagihara, K, Sugimura, T, Ushijima, T.
- Journal Title
  
  Cancer Res 62
  
  Pages: 6645-50
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213150
[Journal Article] Silencing of HTR1B and reduced expression of EDN1 in human lung cancers, revealed by methylation-sensitive representational difference analysis.2001
- Author(s)
  Takai, D, Yagi, Y, Wakazono, K, Ohishi, N, Morita, Y, Sugimura, T, Ushijima, T.
- Journal Title
  
  Oncogene 20
  
  Pages: 7505-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213150
[Presentation] Vicious combination of dysregulated methylation machineries induced by chronic inflammation2017
- Author(s)
  竹島　秀幸、丹羽　透、山下　聡、牛島　俊和
- Organizer
  The 72nd Fujihara Seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] 炎症の悪い組み合わせは、DNA メチル化関連因子の制御異常を引き起こす2017
- Author(s)
  竹島　秀幸、丹羽　透、山下　聡、牛島　俊和
- Organizer
  第40回日本分子生物学会年会・第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] エピジェネティック治療の重要性とさらなる応用拡大2017
- Author(s)
  牛島　俊和
- Organizer
  第15回日本臨床腫瘍学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] Induction of an epigenetic field involving epithelial and stromal cells by chronic inflammation2017
- Author(s)
  牛島　俊和、竹島　秀幸、前田　将宏
- Organizer
  The 72nd Fujihara Seminar
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] 組織におけるエピゲノム傷害の程度は、発がん要因への曝露期間により決まる2017
- Author(s)
  竹島　秀幸、丹羽　透、豊田　武士、山下　聡、牛島　俊和
- Organizer
  第11回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] Methylation burden and gastric cancer2017
- Author(s)
  牛島　俊和
- Organizer
  The 12th International Gastric Cancer Congress (IGCC)
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] Induction of an epigenetic field involving epithelial and stromal cells by chronic inflammation2017
- Author(s)
  牛島　俊和
- Organizer
  France Japan Epigenetics Workshop 2017
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] 一件正常な細胞でのDNAメチル化異常の蓄積とがん発症2017
- Author(s)
  牛島　俊和
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-24
- Invited
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] 慢性炎症により誘発されるDNAメチル化装置制御異常の悪い組み合わせ2017
- Author(s)
  竹島　秀幸、丹羽　透、山下　聡、若林　美香、牛島　俊和
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] Molecular mechanism of gastric carcinogenesis: for precision risk diagnosis and epigenetic therapy2017
- Author(s)
  牛島　俊和
- Organizer
  The 12th International Gastric Cancer Congress (IGCC)
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] Vicious combination of dysregulated methylation machineries induced by chronic inflammation2017
- Author(s)
  竹島　秀幸、丹羽　透、山下　聡、牛島　俊和
- Organizer
  12th Asian Epigenomics Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] 性炎症による疾患におけるエピジェネティック異常の重要な役割2016
- Author(s)
  牛島　俊和
- Organizer
  第10回日本エピジェネティクス研究会年会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Year and Date
  2016-05-19
- Invited
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] Field cancerization now gains ground2016
- Author(s)
  牛島　俊和
- Organizer
  第102回日本消化器病学会総会（第5回国際交流フォーラム）
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-04-21
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] 慢性炎症によるTet遺伝子の発現抑制と異常DNAメチル化誘発2015
- Author(s)
  竹島秀幸, 丹羽透, 若林美香, 山下聡, 牛島俊和
- Organizer
  第30回発癌病理研究会
- Place of Presentation
  オリビアン小豆島（香川県小豆郡）
- Year and Date
  2015-08-26
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] Mechanisms of formation of epigenetic cancerization field by chronic inflammation2015
- Author(s)
  Ushijima T
- Organizer
  GRL Korea-Japan Epigenome Medicine Meeting 2015
- Place of Presentation
  ダブルツリーbyヒルトン那覇（沖縄県那覇市）
- Year and Date
  2015-05-17
- Data Source
  KAKENHI-PROJECT-15H04302
[Presentation] The presence of strong target gene specificity in induction of DNA methylation, and its mechanisms.2009
- Author(s)
  Ushijima T.
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] The presence of strong target gene specificity in induction of DNA methylation, and its mechanisms.2009
- Author(s)
  Ushijima, T.
- Organizer
  Epigenetics in Development and Diseases Conference : 4th Asian Epigenomics Meeting.
- Place of Presentation
  Singapore
- Year and Date
  2009-08-25
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] The presence of strong target gene specificity in induction of DNA methylation, and its mechanisms.2009
- Author(s)
  Ushijima T.
- Organizer
  Epigenetics in Development and Diseases Conference: 4th Asian Epigenomics Meeting.
- Place of Presentation
  Singapore
- Year and Date
  2009-08-25
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] Instructive induction of aberrant DNA methylation, and epigenomic analysis of its underlying mechanisms.2009
- Author(s)
  Ushijima T.
- Organizer
  Epigenetics 2009 Australian Scientific Meeting.
- Place of Presentation
  Melbourne
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] The presence of strong target gene specificity in induction of DNA methylation, and its mechanisms.2009
- Author(s)
  Ushijima, T.
- Organizer
  第68回日本癌学会学術総会International Session
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-17012017
[Presentation] The presence of strong target gene specificity in induction of DNA methylation, and its mechanisms.2009
- Author(s)
  Ushijima T.
- Organizer
  18th Cancer Research Institute cancer symposium on "DNA and Histone Methylation in Cancer".
- Place of Presentation
  Seoul
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] Instructive induction of aberrant DNA methylation, and epigenomic analysis of its underlying mechanisms.2009
- Author(s)
  Ushijima T.
- Organizer
  第32回日本分子生物学会年会シンポジウム
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] DNA methylation induction by Helicobacter pylori infection in human gastric mucosae and target gene specificity.2008
- Author(s)
  Nakajima T, Yamashita S, Maekita T, Niwa T, Nakazawa K, Ushijima T.
- Organizer
  67th JCA meeting.
- Place of Presentation
  Nagoya
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] Expression and methylation changes of APC 1A and 1B in gastric carcinogenesis.2008
- Author(s)
  Hosoya, K., Yamashita, S., Ando, T., Nakajima, T., Nakanishi, Y., Itoh, F., and Ushijima, T.
- Organizer
  67^<th> JCA meeting
- Place of Presentation
  Nagoya
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] DNA methylation induction by Helicobacter pylori infection in human gastric mucosae and target gene specificity.2008
- Author(s)
  Nakajima, T., Yamashita, S., Maekita, T., Niwa, T., Nakazawa, K., and Ushijima, T.
- Organizer
  67^<th> JCA meeting
- Place of Presentation
  Nagoya
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] Expression and methylation changes of APC 1A and 1B in gastric carcinogenesis.2008
- Author(s)
  Hosoya K, Yamashita S, Ando T, Nakajima T, Nakanishi Y, Itoh F, Ushijima T.
- Organizer
  67th JCA meeting.
- Place of Presentation
  Nagoya
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] Epigenetic field for cancerization2007
- Author(s)
  Ushijima, T.
- Organizer
  11th German-Japan Cancer Research Workshop
- Place of Presentation
  Kyoto (Japan) Kvoto Garden Palace
- Year and Date
  2007-11-29
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] DNA methylation as a marker for the past and future2007
- Author(s)
  Ushijima, T.
- Organizer
  The New Zealand Society for Oncology Conference
- Place of Presentation
  Dunedin (NewZealand) Dunedin Centre
- Year and Date
  2007-05-11
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] Environment-epigenome interaction2007
- Author(s)
  Ushijima, T.
- Organizer
  Symposium by Asian Network of Epigenomics
- Place of Presentation
  Osaka (Japan) Institute for Protein Research
- Year and Date
  2007-06-14
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] Epigenetic field defect for gastric cancers2007
- Author(s)
  Ushijima, T.
- Organizer
  Gordon Research Conference
- Place of Presentation
  Lucca (Italy) Il Ciocco
- Year and Date
  2007-05-22
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] 神経芽腫の強力予後因子としてのDNAメチル化2007
- Author(s)
  牛島俊和
- Organizer
  小児癌学会・小児血液学会シンポジウム
- Place of Presentation
  宮城県仙台市仙台国際センター
- Year and Date
  2007-12-15
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] Epigenetic field defect for gastric cancers, and its use as a cancer risk marker.2007
- Author(s)
  Ushijima T, Nakajima T.
- Organizer
  The 11th Annual Meeting of Taiwan Cooperative Oncology Group.
- Place of Presentation
  Taipei
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] Epigenetic field defect for gastric cancers.2007
- Author(s)
  Ushijima T, Nakajima T, Enomoto S.
- Organizer
  Gordon Research Conference.
- Place of Presentation
  Il Ciocco
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] Epigenetic field defect for gastric cancers, and its use as a cancer riskmarker2007
- Author(s)
  Ushijima, T.
- Organizer
  The llth Annual Meeting of Taiwan Cooperative Oncology Group
- Place of Presentation
  Taipei (Taiwan) Howard International House
- Year and Date
  2007-12-02
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] エピジェネティクスからみた多段階発がん2007
- Author(s)
  牛島俊和
- Organizer
  日本エピジェネティクス研究会
- Place of Presentation
  大阪府吹田市大阪大学コンベンションセンター
- Year and Date
  2007-06-16
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] Epigenetics in Cancers and Polyclonal Disorders2007
- Author(s)
  牛島俊和
- Organizer
  日本薬物動態学会ビジョンシンポジウム
- Place of Presentation
  東京都港区共立薬科大学
- Year and Date
  2007-07-19
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] エピジェネティックな発がんの場2007
- Author(s)
  牛島俊和
- Organizer
  日本癌学会66回総会シンポジウム
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] DNA methylation induction by Helicobacter pylori, and use as a cancer risk marker2007
- Author(s)
  Ushijima, T.
- Organizer
  The 19th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Conference
- Place of Presentation
  Seoul(Korea)COEX Center
- Year and Date
  2007-05-29
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] A chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.2006
- Author(s)
  Yamashita S, Tsujino Y, Moriguchi K, Tatematsu M, Ushijima T.
- Organizer
  Annual Meeting of American Association for Cancer Research.
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] Helicobacter pyloriによる胃粘膜でのDNAメチル化異常誘発2006
- Author(s)
  牛島俊和
- Organizer
  日本分子生物学会2006フォーラム
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] エピジェネティックな異常の起源と加速Helicobacter pyloriによるDNAメチル化異常誘発とCpGアイランド特異性2006
- Author(s)
  牛島俊和
- Organizer
  日本癌学会65回総会シンポジウム
- Data Source
  KAKENHI-PROJECT-17013090
[Presentation] ヘリコバクター・ピロリ感染による異常dnaメチル化の高度の蓄積2005
- Author(s)
  前北隆雄、中沢和之、中島健、三原真美、清水靖仁、杉村隆、斉藤大三、一瀬雅夫、牛島俊和
- Organizer
  第64回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17013090

1. OGAWA Katsuhiro (50045514)

# of Collaborated Projects: 3 results

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2. 長尾美奈子 (40100151)

# of Collaborated Projects: 3 results

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3. ASADA Kiyoshi (50311410)

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6. YAMAMURA Kenichi (90115197)

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7. YAMADA Gen (80174712)

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8. ARAKI Kimi (90211705)

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9. ITOH Toshio (20106644)

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10. KATOH Hideki (30142053)

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11. NAKAGATA Naomi (30159058)

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13. OBATA Yuichi (30177290)

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14. YAMAZAKI Yukiko (00239956)

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24. KITAMURA Toshio (20282527)

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25. KAWAMOTO Hiroshi (00343228)

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28. MIYAJIMA Atsushi (50135232)

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37. NARITA Yoshitaka (40392344)

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38. 北川知行 (50085619)

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57. 堺隆一 (40215603)

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USHIJIMA Toshikazu 牛島 俊和

牛島 俊和 ウシジマ トシカズ

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iPS発がんモデルとゲノム編集スクリーニングによる神経芽腫エピゲノム療法開発Ongoing

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lnc162によるDNA脱メチル化剤感受性増強の分子機構の解明Principal InvestigatorOngoing

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Clarification of molecular mechanism of aberrant DNA methylation induction by chronic inflammationPrincipal Investigator

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Identification of tumor suppressor genes in gastric cancers by genome-wide analysis of DNA methylation and its functional analysisPrincipal Investigator

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Identification of genes silenced in human gastric cancersPrincipal Investigator

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Abnormalities in maintenance of methylation and carcinogenesis.Principal Investigator

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USHIJIMA Toshikazu 牛島俊和

牛島俊和ウシジマトシカズ