kobayashi takashi 小林孝志

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KOBAYASHI Takashi 小林孝志

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Researcher Number	90234830
Other IDs
Affiliation (Current)	2025: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 皮膚科学, 准教授
Affiliation (based on the past Project Information) *help	2003 – 2006: 千葉大学, 医学部附属病院, 講師 2001 – 2002: 千葉大学, 大学院・医学研究院, 助手 1999 – 2000: 千葉大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Dermatology / Dermatology
Keywords	Principal Investigator MMP-9 / 分化 / ケラチノサイト / decoy oligonucleotide / RNA interference / leptomycin B / involucrin / caspase / matrix metalloproteinase / TIMP-2 … More / Toxic epidermal necrolysis / Leptomycin B / KRE-M9 / Fibroblast / Keratinocyte / Differentiation / Apoptosis / Matrix metalloproteinase-9 / 線維芽細胞 / アポトーシス / 転写因子 / inflammation / gelatinase / 創傷治癒 / 角化 / 炎症 / ジェラティネイス / HT1080 cell / TPA responsive element / TIMP-1 / MMP-2 / マトリックスメタロプロテイネイス / RNAi / UVB / 紫外線 / DRF-1 / 中毒性表皮壊死症 / レプトマシシンB / HT1080細胞 / マトリックスメタロプロテイネイス-9 / In situ zymography / HT-1080 cell / Transcription factor / matrix metalloproteinase-9 / マトリックスメタロプロテアーゼ / In situザイモグラフ法 / HT-1080細胞 / マトリックスメタロプロテアーゼ-9 / glucose-6-phosphatase / ワンハイブリッド法 / インボルクリン / matrix metalloproteinase 9 Less

Basic study for the treatment of inflammatory skin diseases using the regulation of gelatinolytic activities.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Takashi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
BASIC STUDY FOR THE TREATMENT OF SKIN DISEASES USING THE REGULATION OF MATRIX METALLOPROTEINASE-9 EXPRESSIONPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Takashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  CHIBA UNIVERSITY
ANALYSIS FOR THE MODULATION OF MATRIX METALLOPROTEINASE-9 EXPRESSION IN APOPTOSISPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Takashi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  CHIBA UNIVERSITY
ヒトケラチノサイトの分化制御転写因子遺伝子のクローニングとその発現についての検討Principal Investigator
- Principal Investigator
  
  小林孝志
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University

All 2005 2004 2003

All Journal Article Book

[Book] 遺伝子医学MOOK 第1巻再生医療へのブレイクスルーその技術革新と今後の方向性内天然分解酵素2004
- Author(s)
  小林孝志
- Total Pages
  6
- Publisher
  メディカルドゥ
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591169
[Book] 遺伝子医学MOOK 第1巻再生医療へのブレイクスルー-その技術革新と今後の方向性内天然分解酵素2004
- Author(s)
  小林孝志
- Total Pages
  6
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] Laminin α 3LG4 module induces keratinocyte migration : Involvement of matrix metalloproteinase-9.2005
- Author(s)
  Momota Y., Suzuki N., Kasuya Y., Kobayashi T., Mizoguchi M.et al.
- Journal Title
  
  J. Recept. Sig. Transd. 25
  
  Pages: 1-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591158
[Journal Article] Leptomycin B reduces matrix metalloproteinase-9 expression and suppresses cutaneous inflammation.2005
- Author(s)
  Kobayashi T., Shinkai H.
- Journal Title
  
  J. Invest. Dermatol. 124
  
  Pages: 331-337
- NAID
  40006752039
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591158
[Journal Article] Leptomycin B redices matrix metalloproteinase-9 expression and suppresses cutaneous inflammation.2005
- Author(s)
  Kobayashi T., Shinkai H.
- Journal Title
  
  J. Invest. Dermatol. 124
  
  Pages: 331-337
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591158
[Journal Article] Lamininα3LG4 module induces keratinocyte migration : Involvement of matrix metalloproteinase-9.2005
- Author(s)
  Momota Y., Suzuki N., Kasuya Y., Kobayashi T., Mizoguchi M., et al.
- Journal Title
  
  J. Recept. Sig. Transd. 25
  
  Pages: 1-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591158
[Journal Article] Leptomycin B reduces matrix metalloproteinase-9 expression and suppresses cutaneous inflammation.2005
- Author(s)
  Kobayashi T., Shinkai H.
- Journal Title
  
  J Invest Dermatol 124
  
  Pages: 331-337
- NAID
  40006752039
- Data Source
  KAKENHI-PROJECT-17591158
[Journal Article] Leptomycin B reduces matrix metalloproteinase-9 expression and suppresses cutaneous inflammation.2005
- Author(s)
  Kobayashi T., Shinkai H.
- Journal Title
  
  J Invest Dermatol 124
  
  Pages: 331-337
- NAID
  40006752039
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] MMP-9 and TIMP-1 assays in keratinocyte cultures.2004
- Author(s)
  Kobayashi T.
- Journal Title
  
  Methods Mol Biol 289
  
  Pages: 201-208
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] Matrix metalloproteinase 9 expression is coordinary modulated by the KRE-M9 and 12-o-tetradecanoyl-phorbol-13-acetate responsive elements.2004
- Author(s)
  Kobayashi T., Kishimoto J., et al.
- Journal Title
  
  J Invest Dermatol 122
  
  Pages: 278-285
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] MMP-9 and TIMP-1 assays in ketratinocyte cultures2004
- Author(s)
  Kobayashi T.
- Journal Title
  
  Methods Mol Biol 289
  
  Pages: 201-208
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] Role of matrix metalloproteinse-9 expression on the cutaneous inflammation : Possible treatment by leptomycin B application2004
- Author(s)
  Kobayashi T.
- Journal Title
  
  Inflammation and Regeneration(in Japanese) 24-5
  
  Pages: 578-583
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] Matrix metalloproteinase 9 expression is coordinately modulated by the KRE-M9 and 12-o-tetradecanoyl-phorbol-13-acetate responsive elements.2004
- Author(s)
  Kobayashi T., Kishimoto J., et al.
- Journal Title
  
  J Invest Dermatol 122・2
  
  Pages: 278-285
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] Matrix metalloproteinase 9 expression is coordinated modulated by the KRE-M9 and 12-o-decanoyl-phorbol-13-acetate responsive elements.2004
- Author(s)
  Kobayashi T., Kishimoto J., Hattori S., Wachi H., Shinkai H., Burgeson RE.
- Journal Title
  
  J.Invest.Dermatol. 122
  
  Pages: 278-285
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] MMP-9 and TIMP-1 assays in keratinocyte cultures.2004
- Author(s)
  Kobayashi T.
- Journal Title
  
  Methods Mol.Biol. 289
  
  Pages: 201-208
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] 皮膚の炎症性疾患におけるmatrix metalloproteinase-9の役割-Leptomycin B投与による治療の可能性について-2004
- Author(s)
  小林孝志
- Journal Title
  
  炎症・再生 24
  
  Pages: 578-583
- NAID
  10026498599
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] In situ detection of gelatinolytic activity in skin specimens of squamous cellcarcinoma : Probable role in dyskeratosis and tumor invasion.2003
- Author(s)
  Kobayashi T.
- Journal Title
  
  Dermatology 206-3
  
  Pages: 281-283
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] Induction of matrix metalloproteinase-9 secretion from human keratinocytes in culture by ultraviolet B irradiation.2003
- Author(s)
  Onoue S., Kobayashi T., Takemoto Y., Sasaki I., Shinkai H.
- Journal Title
  
  J.Dermatol.Sci. 33
  
  Pages: 105-111
- NAID
  10012661657
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] Matrix metalloproteinases-2 and -9 are secreted from human fibroblasts.2003
- Author(s)
  Kobayashi T., Hattori S., et al.
- Journal Title
  
  Acta Derm Venerol 83
  
  Pages: 105-107
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] Induction of matrix metalloproteinase-9 secretion from human keratinocytes in culture by ultraviolet B irradiation.2003
- Author(s)
  Onoue S., Kobayashi T., et al.
- Journal Title
  
  J Dermatol Sci 33
  
  Pages: 105-111
- NAID
  10012661657
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] In situ detection of gelatinolytic activity in skin specimens of squamous cell carcinoma : Probable role in dyskeratosis and tumor invasion.2003
- Author(s)
  Kobayashi T.
- Journal Title
  
  Dermatology 206
  
  Pages: 281-283
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591169
[Journal Article] Matrix metalloproteinases-2 and -9 are secreted from human fibroblasts.2003
- Author(s)
  Kobayashi T., Hattori S., Shinkai H.
- Journal Title
  
  Acta Derm.Venereol. 83-2
  
  Pages: 105-107
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591169

1. WACHI Hiroshi (50318614)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results

kobayashi takashi 小林 孝志

KOBAYASHI Takashi 小林 孝志

Research Projects

Research Products

Co-Researchers

Basic study for the treatment of inflammatory skin diseases using the regulation of gelatinolytic activities.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

BASIC STUDY FOR THE TREATMENT OF SKIN DISEASES USING THE REGULATION OF MATRIX METALLOPROTEINASE-9 EXPRESSIONPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ANALYSIS FOR THE MODULATION OF MATRIX METALLOPROTEINASE-9 EXPRESSION IN APOPTOSISPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒトケラチノサイトの分化制御転写因子遺伝子のクローニングとその発現についての検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 遺伝子医学MOOK 第1巻 再生医療へのブレイクスルーその技術革新と今後の方向性 内 天然分解酵素2004

Author(s)

Total Pages

Publisher

Description

Data Source

[Book] 遺伝子医学MOOK 第1巻 再生医療へのブレイクスルー-その技術革新と今後の方向性 内 天然分解酵素2004

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Laminin α 3LG4 module induces keratinocyte migration : Involvement of matrix metalloproteinase-9.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Leptomycin B reduces matrix metalloproteinase-9 expression and suppresses cutaneous inflammation.2005

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Leptomycin B redices matrix metalloproteinase-9 expression and suppresses cutaneous inflammation.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Lamininα3LG4 module induces keratinocyte migration : Involvement of matrix metalloproteinase-9.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Leptomycin B reduces matrix metalloproteinase-9 expression and suppresses cutaneous inflammation.2005

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Leptomycin B reduces matrix metalloproteinase-9 expression and suppresses cutaneous inflammation.2005

Author(s)

Journal Title

NAID

Data Source

[Journal Article] MMP-9 and TIMP-1 assays in keratinocyte cultures.2004

Author(s)

Journal Title

Data Source

[Journal Article] Matrix metalloproteinase 9 expression is coordinary modulated by the KRE-M9 and 12-o-tetradecanoyl-phorbol-13-acetate responsive elements.2004

Author(s)

Journal Title

Description

Data Source

kobayashi takashi 小林孝志

KOBAYASHI Takashi 小林孝志

[Book] 遺伝子医学MOOK 第1巻再生医療へのブレイクスルーその技術革新と今後の方向性内天然分解酵素2004

[Book] 遺伝子医学MOOK 第1巻再生医療へのブレイクスルー-その技術革新と今後の方向性内天然分解酵素2004