Miyata Masaaki 宮田昌明

… Alternative Names

MIYATA Masaaki 宮田昌明

宮田昌明ミヤタマサアキ

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Researcher Number	90239418
External Links
Affiliation (Current)	2025: 国立研究開発法人水産研究・教育機構, 水産大学校, 教授
Affiliation (based on the past Project Information) *help	2016 – 2023: 国立研究開発法人水産研究・教育機構, 水産大学校, 教授 2013: 独立行政法人水産大学校, その他部局等, 教授 2011 – 2012: 東北大学, 薬学研究科(研究院), 助教 2007 – 2012: 東北大学, 大学院・薬学研究科, 助教 2006: Tohoku University Grad. Sch. Pharm.Sci., Reserch Instructor, 大学院薬学研究科, 助手 1999 – 2005: 東北大学, 大学院・薬学研究科, 助手 1993 – 1994: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 59040:Nutrition science and health science-related / 応用薬理学・医療系薬学 / Eating habits / 医薬分子機能学 Except Principal Investigator Medical pharmacy / 応用薬理学・医療系薬学 / Biological pharmacy
Keywords	Principal Investigator 脂肪性肝疾患 / FXR / 胆汁酸 / タウリン / 消化管 / 脂質代謝 / コレステロール / bile acid / PCN / lithocholic acid … More / 細胞増殖 / 腸内細菌 / 発現調節 / marine food / dyslipidemia / intestine / TMAO / アルギン酸 / 水産機能成分 / selenoneine / hypercholesterolemia / FGF15/19 / taurine / NAFLD / トリメチルアミンオキサイド / 水産食品 / セレン / セレノネイン / 食品 / 農林水産物 / 魚油 / phospholipid / cholestasis / hepatotoxicity / microarray / lipid metabolism / リン脂質 / マイクロアレイ / probucol / 胆汁鬱滞 / 肝障害 / Knock-out mice / Epoxide hydrolase / Teratogenicity / Embryo fibroblast / Thalidomide / 遺伝子欠損マウス / ノックアウトマウス / ノックマウトマウス / エポキシドヒドロラーゼ / 催奇形性 / 胎児線維芽細胞 / サリドマイド / FXR欠損マウス / 糖代謝 / 細胞増殖作用 / FGF受容体 / FGF19受容体 / FGF19 / 消化管吸収 / アンピシリン / 二次胆汁酸 / 回腸胆汁酸吸収 / 抗菌薬 / ASBT / 分子多型 / 抗オリゴペプチド抗体 / CYP3A5 / CYP3A4 / 肝臓 / 薬物代謝酵素 … More Except Principal Investigator CYP3A4 / PXR / 核内受容体 / in vivo / Induction / レポーターアッセイ / flutamide / lithocholic acid / FXR / cholic acid / ampicillin / Sult2a / hepatotoxicity / nuclear receptor / cis-element / human / Adenovirus / P450 / CAR / 炎症 / 肝非実質細胞 / 薬剤性肝障害 / 転写調節 / 肝毒性 / 安全性学 / 医薬品情報 / 脂質代謝 / 肝障害 / 胆汁酸 / CYP3A / リトコール酸 / 毒性機序 / モデル動物 / TCPOBOP / induction / Lithocholic acid / Liver toxicity / Bile acid / 誘導 / human drug metabolism / stable expression / enzyme induction / cyt.P450 / スクリーニング / 安定発現株 / 誘導評価系 / インダクション / ヒト薬物代謝 / 安定発現 / 酵素誘導 / Nuclear Receptor / rat / CYP3A1 / Nuclear receptor / sis-element / 発がん性試験 / PPARα / 細胞増殖 / 肝化学発がん / マクロファージ / 炎症シグナル / 肝発がん / 細胞周期 / 動物試験代替法 / 抗菌薬 / 19 / FGF15 / CD36 / トリグリセリド / 腸内細菌 / FGF15/19 / グルタチオン / ME3738 / probucol / 脂質 / マイクロアレイ / xanthine oxidase / トキシコゲノミクス / フルタミド / コレステロール / Hepatotoxicity / sulfotransferase2A Less

Preventive mechanisms of dyslipidemia by bile acid-mediated gastrointestinal signal due to marine food componentsPrincipal Investigator
- Principal Investigator
  
  宮田昌明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Fisheries Research and Education Agency
A new dietary preventive strategy targeting regulation of gastrointestinal bile acid metabolism for fatty liver diseasePrincipal Investigator
- Principal Investigator
  
  Miyata Masaaki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Fisheries Research and Education Agency
The protection of fatty liver disease by fish-derived dietary habit targeted to intestinal bile acid controlPrincipal Investigator
- Principal Investigator
  
  Miyata Masaaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Fisheries Research and Education Agency
化学物質のヒトでの安全性評価のための核内受容体CARを介した肝発がん機構の解明
- Principal Investigator
  
  山添康
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Regulation of glucose and lipid metabolism through specific receptor-responsive FGF19 proteinPrincipal Investigator
- Principal Investigator
  
  MIYATA Masaaki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  National Fisheries University
  Tohoku University
Understanding of molecular mechanism and development of prediction system of drug- induced hepatotoxicity, focusing on the inflammation-associated nuclear receptors and cell-cell interactions.
- Principal Investigator
  
  YOSHINARI Kouichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Understanding of the mechanism for the nuclear receptor-mediated hepatotoxicity and establishment of the prediction and evaluation system for the toxicity.
- Principal Investigator
  
  YOSHINARI Kouichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Regulation of hepatic lipid metabolism through ileal bile acid-FGF signaling
- Principal Investigator
  
  YAMAZOE Yasushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Role of ileal bile acid absorption on regulation of serum cholesterol levelsPrincipal Investigator
- Principal Investigator
  
  MIYATA Masaaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Mechanisms for delayed organ toxicity induced by drug and prediction system using comprehensive analysis
- Principal Investigator
  
  YAMAZOE Yasushi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Mechanism for human-specific hepatotoxicity and development of prediction system
- Principal Investigator
  
  YAMAZOE Yasushi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Novel protective mechanisms for cholestatic hepatotoxicity-application to drug improving hepatic functionPrincipal Investigator
- Principal Investigator
  
  MIYATA Masaaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Bile acids, key compounds for the mechanistic analyses of hepatotoxicity, and nuclear receptor interaction
- Principal Investigator
  
  YAMAZOE Yasushi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
核内オーファンレセプターFXRによる脂質代謝調節の解明
- Principal Investigator
  
  YAMAZOE Yasushi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
Human characteristic mechanism of enzyme induction and the prediction
- Principal Investigator
  
  YAMAZOE Yasushi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tohoku University
In vivo Molecular Mechanism of Human CYP3A Induction Involved in Drug Interaction
- Principal Investigator
  
  NAGATA Kiyoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tohoku University
Analysis of mechanism for thalidomide-induced teratogenicity using knock-out micePrincipal Investigator
- Principal Investigator
  
  MIYATA Masaaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tohoku University
エピトープ特異性抗ヒトCYP3A抗体の作製とヒトにおける分子多型の解析Principal Investigator
- Principal Investigator
  
  宮田昌明
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Keio University
薬物代謝酵素遺伝子の肝特異的活性化機序の解析Principal Investigator
- Principal Investigator
  
  宮田昌明
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Keio University

[Journal Article] Trimethylamine N-oxide ameliorates hepatic damage including reduction of hepatic bile acids and cholesterol in Fxr-null mice2024
- Author(s)
  Masaaki Miyata, Kento Takeda, Sayuri Nagira, Yoshimasa Sugiura
- Journal Title
  
  International Journal of Food Sciences and Nutrition
  
  Volume: 4 Issue: 4 Pages: 385-395
- DOI
  10.1080/09637486.2024.2346765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K11743
[Journal Article] 食事成分による消化管の胆汁酸/FXRシグナルを介する脂質異常症の予防2022
- Author(s)
  宮田昌明
- Journal Title
  
  アグリバイオ
  
  Volume: 6 Pages: 1346-1349
- Data Source
  KAKENHI-PROJECT-19K11811
[Journal Article] Cholesterol-lowering effects of taurine through the reduction of ileal FXR signaling due to the alteration of ileal bile acid composition.2021
- Author(s)
  M. Miyata, T. Tanaka, K. Takahashi, A. Funaki and Y. Sugiura
- Journal Title
  
  Amino Acids
  
  Volume: 53 Issue: 10 Pages: 1523-1532
- DOI
  10.1007/s00726-021-03068-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K11811
[Journal Article] Selenoneine Ameliorates Hepatocellular Injury and Hepatic Steatosis in a Mouse Model of NAFLD2020
- Author(s)
  M. Miyata, K. Matsushita, R. Shindo, Y. Shimokawa, Y. Sugiura and M. Yamashita.
- Journal Title
  
  Nutrients
  
  Volume: 12 Issue: 6 Pages: 1898-1898
- DOI
  10.3390/nu12061898
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11811
[Journal Article] Taurine attenuates hepatic steatosis in a genetic model of fatty liver disease2020
- Author(s)
  Masaaki Miyata, Akihiro Funaki, Chiaki Fukuhara, Yukino Sumiya, Yoshimasa Sugiura
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 2 Pages: 87-94
- DOI
  10.2131/jts.45.87
- NAID
  130007798444
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07951, KAKENHI-PROJECT-19K11811
[Journal Article] Fish oil feeding reverses hepatomegaly and disrupted hepatic function due to the lack of FXR signaling2017
- Author(s)
  M. Miyata, K. Shinno, T. Kinoshita, Y. Kinoshita, Y. Sugiura,
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 42 Issue: 6 Pages: 671-681
- DOI
  10.2131/jts.42.671
- NAID
  130006206263
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00904
[Journal Article] SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells.2014
- Author(s)
  M. Miyata, T. Hata, Y. Yamazoe and K. Yoshinari
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 443 Issue: 2 Pages: 477-482
- DOI
  10.1016/j.bbrc.2013.11.126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659064
[Journal Article] SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells2014
- Author(s)
  M. Miyata, T. Hata, Y. Yamazoe and K. Yoshinari
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 443 Pages: 477-482
- Data Source
  KAKENHI-PROJECT-24659064
[Journal Article] Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.2013
- Author(s)
  Ryota Shizu, Satoshi Benoki, Yuki Numakura, Susumu Kodama, Masaaki Miyata, Yasushi Yamazoe, Kouichi Yoshinari
- Journal Title
  
  PLOS ONE
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390027
[Journal Article] Ileal apical sodium-dependent bile acid transporter protein levels are down-regulated through ubiquitin-dependent protein degradation induced by bile acids2013
- Author(s)
  M. Miyata, H. Yamakawa, K. Hayashi, H. Kuribayashi, Y. Yamazoe　and　K. Yoshinari
- Journal Title
  
  Euro. J. Pharmacol.
  
  Volume: 714 Issue: 1-3 Pages: 507-514
- DOI
  10.1016/j.ejphar.2013.06.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659064
[Journal Article] Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor -α (PPARα) is enhanced by pregnane X receptor (PXR) sctivation in mice2013
- Author(s)
  Shizu R, Benoki S, Numakura Y, SusumuKodama S, Miyata M, Yamazoe Y, Yoshinari K
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Issue: 4 Pages: e61802-e61802
- DOI
  10.1371/journal.pone.0061802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390027
[Journal Article] Enterobacteria-mediated deconjugation of taurocholic acid enhances ileal FXR signaling2012
- Author(s)
  H. Kuribayashi, M. Miyata, H. Yamakawa, K. Yoshinari and Y. Yamazoe
- Journal Title
  
  Eur. J. Pharmacol
  
  Volume: 697 Issue: 1-3 Pages: 132-138
- DOI
  10.1016/j.ejphar.2012.09.048
- Data Source
  KAKENHI-PROJECT-24659064
[Journal Article] 胆汁酸-FGF系による脂質代謝調節への腸管からのシグナル2012
- Author(s)
  宮田昌明、山添康
- Journal Title
  
  The Lipid
  
  Volume: 107
- Data Source
  KAKENHI-PROJECT-21390039
[Journal Article] Involvement of multiple elements in FXR-mediatedtranscriptional activation of FGF192012
- Author(s)
  M. Miyata, T. Hata, H. Yamakawa, T. Kagawa, K. Yoshinari and Y. Yamazoe
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume: 132 Issue: 1-2 Pages: 41-47
- DOI
  10.1016/j.jsbmb.2012.04.008
- Data Source
  KAKENHI-PROJECT-24659064
[Journal Article] 胆汁酸―FGF系による脂質代謝調節への腸管からのシグナル2012
- Author(s)
  宮田昌明、山添康
- Journal Title
  
  The Lipid
  
  Volume: 23 Pages: 266-271
- URL
  http://med.m-review.co.jp/magazine/detaill/J07_23_3_46-51.html
- Data Source
  KAKENHI-PROJECT-24659064
[Journal Article] Involvement of multiple elements in FXR-mediated transcriptional activation of2012
- Author(s)
  M. Miyata, T. Hata, H. Yamakawa, T. Kagawa, K. Yoshinari, and Y Yamazoe
- Journal Title
  
  FGF19 J Steroid Biochem Mol Biol
- URL
  http://dx.doi.org/10.1016/j.jsbmb
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390039
[Journal Article] Enterobacteria modulate intestinal bile acid transport and homeostasis through apical sodium-dependent bile acid transporter (SLC10A2) expression2011
- Author(s)
  M.Miyata, H.Yamakawa, M.Hamatsu, H.Kuribayashi, Y.Takamatsu, Y.Yamazoe
- Journal Title
  
  J.Pharmacol.Exp.Ther. 336
  
  Pages: 188-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590137
[Journal Article] Amelioration of disrupted hepatic lipogenesis in Fxr-null mice by human FGF19 treatment2011
- Author(s)
  M Miyata, Y. Sakaida, H. Matsuzawa, K. Yoshinari and Y. Yamazoe
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: 34 Pages: 1885-1889
- URL
  http://dx.doi.org/10.1248/bpb.34.1885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390039
[Journal Article] Enterobacteria modulate intestinal bile acid transport and homeostasis through apical sodium-dependent bile acid transporter (SLC10A2) expression2011
- Author(s)
  M.Miyata, et al.
- Journal Title
  
  J.Pharmacol.Exp.Ther.
  
  Volume: 336 Pages: 188-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590137
[Journal Article] Enterobacteria modulate intestinal bile acid transport and homeostasis through apical sodium-dependent bile acid transporter (SLC10A2) expression2011
- Author(s)
  M.Miyata, et al.
- Journal Title
  
  J.Pharmacol.Exp.Ther.
  
  Volume: 336 Pages: 188-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390039
[Journal Article] Amelioration of disrupted hepatic lipogenesis in Fxr-null mice by human FGF19 treatment2011
- Author(s)
  M.Miyata, et al
- Journal Title
  
  Biol.Pharm.Bull
  
  Volume: 34 Pages: 1885-1889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390039
[Journal Article] Possible protective-role of pregnenolone-16α-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis.2010
- Author(s)
  M.Miyata, M.Nomoto, F.Sotodate, T.Mizuki, W.Hori, M.Nagayasu, S.Yokokawa, S.Ninomiya, Y.Yamazoe.
- Journal Title
  
  Eur.J.Pharmacol. 636
  
  Pages: 145-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590137
[Journal Article] Possible protective-role of pregnenolone-16α-carbonitrile in lithocholic acid-inducd hepatotoxicity through enhanced hepatic lipogenesis2010
- Author(s)
  M.Miyata, et al.
- Journal Title
  
  Fur.J.Pharmacol
  
  Volume: 636 Pages: 145-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390039
[Journal Article] Possible protcctive-role of pregnenolone-16α-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis.2010
- Author(s)
  M.Miyata, et al.
- Journal Title
  
  Eur.J.Pharmacol
  
  Volume: 636 Pages: 145-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590137
[Journal Article] Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed Fxr-null mice : FXR-independent suppression of intestinal bile acid absorption2009
- Author(s)
  M.Miyata, Y.Matsuda, M.Nomoto, Y.Takamatsu, N.Sato, M.Hamatsu, P.A.Dawson, F.J.Gonzalez, Y.Yamazoe.
- Journal Title
  
  Drug Metab.Dispos. 37
  
  Pages: 338-344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590137
[Journal Article] Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal FGF15 expression2009
- Author(s)
  M.Miyata, et al.
- Journal Title
  
  J.Pharmacol.Exp.Ther. 331
  
  Pages: 1079-1085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390039
[Journal Article] Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal FGF15 expression2009
- Author(s)
  M.Miyata, et al.
- Journal Title
  
  J.Pharmacol.Exp.Ther. 331
  
  Pages: 1079-1085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590137
[Journal Article] Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal FGF15 expression2009
- Author(s)
  M.Miyata, Y.Takamatsu, H.Kuribayashi, Y.Yamazoe.
- Journal Title
  
  J.Pharmacol.Exp.Ther. 331
  
  Pages: 1079-1085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590137
[Journal Article] Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal FGF15 expression2009
- Author(s)
  M. Miyata, Y. Takamatsu, H. Kuribayashi and Y. Yamazoe
- Journal Title
  
  J. Pharmacol. Exp. Ther
  
  Volume: 331 Pages: 1079-1085
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/20884752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390039
[Journal Article] Role of enzymatic N-hydroxylation and reduction in flutamide metabolite-induced livertoxicity2009
- Author(s)
  M. Ohbuchi, M. Miyata, D. Nagai, M. Shimada, K. Yoshinari and Y. Yamazoe
- Journal Title
  
  Drug Matab.Dispos. 37
  
  Pages: 97-105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390037
[Journal Article] Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed Fxr-null mice : FXR-independent suppression of intestinal bile acid absorption2009
- Author(s)
  M. Miyata, et.al.
- Journal Title
  
  Drug Metab. Dispos. 37
  
  Pages: 338-344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590137
[Journal Article] Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor2009
- Author(s)
  M. Nomoto, M. Miyata, S. Yin, Y. Kurata, M. Shimada, K. Yoshinari, F. J Gonzalez, K. Suzuki, S. Shibasaki, T. Kurosawa,and Y. Yamazoe
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages: 172-178
- NAID
  110007042166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390037
[Journal Article] PPARa gene expression is up-regulated by LXR and PXR activators in the small intestine.2008
- Author(s)
  J.Inoue, S.Satoh, M.Kita, M.Nakahara, S.Hachimura, M.Miyata, T.Nishimaki-Mogami, R.Sato
- Journal Title
  
  Biochem.Biophys.Res.Commun. 371
  
  Pages: 675-678
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590137
[Journal Article] ME3738 protects against lithocholic acid-induced hepatotoxicity, associated with enhancemnt in biliary bile acid and cholesterol output2007
- Author(s)
  M. Nomoto, M. Miyata, M Shimada, K. Yoshinari, F. J Gonzalez, S. Shibasaki, T. Kurosawa, Y. Shindo, Y. Yamazoe
- Journal Title
  
  Eur.J.Pharmacol 574
  
  Pages: 192-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390037
[Journal Article] Chenodeoxycholic acid-mediated activation of the famesoid X receptor negatively regulates hydroxysteroid sulfotransferase2006
- Author(s)
  M.Miyata, Y.Matsuda, H.Tsuchiya, H.Kitada, T.Akase, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe
- Journal Title
  
  Drug Metab Pharmacokin. 21
  
  Pages: 322-330
- Data Source
  KAKENHI-PROJECT-17590114
[Journal Article] Chenodeoxycholic acid-mediated activation of the famesoid X receptor negatively regulates hydroxysteroid sulfotransferase2006
- Author(s)
  M.Miyata, Y.Matsuda, H.Tsuchiya, H.Kitada, T.Akase, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe
- Journal Title
  
  Drug Metab. Pharmacokin. 21
  
  Pages: 322-330
- Data Source
  KAKENHI-PROJECT-17390039
[Journal Article] Role for enhanced fecal excretion of bile acid, in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity2006
- Author(s)
  M.Miyata, H.Watase, W.Hori, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe
- Journal Title
  
  Xenobiotica 36
  
  Pages: 631-644
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590114
[Journal Article] Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase.2006
- Author(s)
  M.Miyata, Y.Matsuda, H.Tsuchiya, H.Kitada, T.Akase, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe.
- Journal Title
  
  Drug Metab. Pharmacokin 21
  
  Pages: 322-330
- NAID
  10018042954
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390039
[Journal Article] Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase.2006
- Author(s)
  M.Miyata, Y.Matsuda, H.Tsuchiya, H.Kitada, T.Akase, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe.
- Journal Title
  
  Drug Metab. Pharmacokin 21
  
  Pages: 322-330
- NAID
  10018042954
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590114
[Journal Article] Role for enhanced tecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity2006
- Author(s)
  M.Miyata, H.Watase, W.Hori, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe
- Journal Title
  
  Xenobiotica 36
  
  Pages: 631-644
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390039
[Journal Article] Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase2006
- Author(s)
  M.Miyata, Y.Matsuda, H.Tsuchiya, H.Kitada, T.Akase, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe
- Journal Title
  
  Drug Metab. Pharmacokin 21
  
  Pages: 322-330
- NAID
  10018042954
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390039
[Journal Article] Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase2006
- Author(s)
  M.Miyata, Y.Matsuda, H.Tsuchiya, H.Kitada, T.Akase, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe
- Journal Title
  
  Drug Metab. Pharmacokin 21
  
  Pages: 322-330
- NAID
  10018042954
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590114
[Journal Article] Role for enhanced fecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity2006
- Author(s)
  M.Miyata, H.Watase, W.Hori, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe
- Journal Title
  
  Xenobiotica 36
  
  Pages: 631-644
- Data Source
  KAKENHI-PROJECT-17590114
[Journal Article] Yamazoe Role for enhanced fecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity2006
- Author(s)
  M.Miyata, H.Watase, W.Hori, M.Shimada, K.Nagata, F.J.Gonzalez, Y.
- Journal Title
  
  Xenobiotica 36
  
  Pages: 631-644
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590114
[Journal Article] Role for enhanced fecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity2006
- Author(s)
  M.Miyata, H.Watase, W.Hori, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe
- Journal Title
  
  Xenobiotica 36
  
  Pages: 631-644
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390039
[Journal Article] Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids : a mechanism for protection against cholic acid-induced liver toxicity2005
- Author(s)
  M.Miyata
- Journal Title
  
  J.Pharmacol.Exp.Ther. 312
  
  Pages: 759-766
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390043
[Journal Article] Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids : a mechanism for protection against cholic acid-induced liver toxicity.2005
- Author(s)
  M.Miyata, A.Tozawa, H.Otsuka, T.Nakamura, K.Nagata, F.J.Gonzalez, Y.Yamazoe
- Journal Title
  
  J.Pharmacol.Exp.Ther. 312
  
  Pages: 759-766
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390043
[Journal Article] Regulation of drug transporter by fernesoid X receptor in mice.2004
- Author(s)
  T.Maeda, M.Miyata, T.Yotsumoto, D.Kobayashi, T.Nozawa, K.Toyama, F.J.Gonzalez, Y.Yamazoe, I.Tamai
- Journal Title
  
  Mol.Pharmaceutics 1
  
  Pages: 281-289
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390043
[Journal Article] 遺伝子欠損動物による薬物代謝酵素の機能解析2003
- Author(s)
  宮田昌明
- Journal Title
  
  薬学雑誌 123
  
  Pages: 569-576
- NAID
  110003614904
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390043
[Journal Article] Functional analysis of drug netabolizing enzymes using gene knockout animals.2003
- Author(s)
  M.Miyata
- Journal Title
  
  Yakugaku Zasshi 123
  
  Pages: 569-576
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390043
[Journal Article] Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity.2003
- Author(s)
  H.Kitada, M.Miyata, T.Nakamura, A.Tozawa, W.Honma, M.Shimada, K.Nagata, C.J.Sinai, G.L.Guo, F.J.Gonzalez, Y.Yamazoe
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 17838-17844
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390043
[Presentation] トリメチルアミンオキサイドの摂取が脂質代謝異常マウスの脂質レベルに与える影響2023
- Author(s)
  宮田昌明、柳楽小百合，武田賢斗，杉浦義正
- Organizer
  日本農芸化学会中四国支部講演会
- Data Source
  KAKENHI-PROJECT-22K11743
[Presentation] 小腸胆汁酸組成の変動に起因する小腸FXRシグナルの減弱を介するタウリンのコレステロール低下作用2022
- Author(s)
  宮田昌明、田中知幸、高橋一帆、舩木萌浩、杉浦義正
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-19K11811
[Presentation] 魚介類のセレン源であるセレノネインの肝脂質代謝への影響2022
- Author(s)
  松下功暉、進藤龍之介、杉浦義正、世古卓也、山下倫明、宮田昌明
- Organizer
  日本農芸化学会中四国支部講演会
- Data Source
  KAKENHI-PROJECT-19K11811
[Presentation] 魚のセレン源のセレノネインは脂肪性肝疾患モデルマウスの肝障害と脂肪肝を軽減する2021
- Author(s)
  宮田昌明、進藤龍之介、下川祐太朗、杉浦義正、山下倫明、宮田昌明
- Organizer
  日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-19K11811
[Presentation] 魚介類のセレン源であるセレノネイン摂取は脂肪性肝疾患モデルマウスの病態を改善させる2020
- Author(s)
  宮田昌明、進藤龍之介、松下功輝、上田裕香子、杉浦義正、山下倫明
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-19K11811
[Presentation] 脂肪性肝疾患モデルマウスにおけるセレノネイン摂取の肝機能への影響2019
- Author(s)
  宮田昌明、進藤龍之介、杉浦義正、山下倫明
- Organizer
  令和元年度日本水産学会秋季大会
- Data Source
  KAKENHI-PROJECT-19K11811
[Presentation] タウリンのコレステロール低下作用におけるFXRシグナルの役割2019
- Author(s)
  宮田昌明、高橋一帆、田中知幸、杉浦義正
- Organizer
  日本農芸化学会中四国支部第５６回講演会
- Data Source
  KAKENHI-PROJECT-19K11811
[Presentation] タウリン摂取によるマウスCyp7a1遺伝子の発現上昇機序2018
- Author(s)
  舩木萌浩，住屋佑希乃、福原千晶、杉浦義正、宮田昌明
- Organizer
  日本農芸化学会中四国支部第50回記念講演会
- Data Source
  KAKENHI-PROJECT-16K00904
[Presentation] タウリン摂取によるFXRシグナルと胆汁酸動態の調節2018
- Author(s)
  宮田昌明、舩木萌浩、江口昌志、住屋佑希乃、杉浦義正
- Organizer
  日本農芸化学会2018年大会
- Data Source
  KAKENHI-PROJECT-16K00904
[Presentation] 脂肪性肝疾患モデルへのタウリン摂取の影響2018
- Author(s)
  宮田昌明、舩木萌浩、福原千晶、住屋佑希乃、杉浦義正
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-16K00904
[Presentation] タウリンによるマウスFXRシグナルと胆汁酸代謝動態の調節2018
- Author(s)
  宮田昌明、舩木萌浩、住屋由紀乃、福原千晶、杉浦義正
- Organizer
  第４５回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-16K00904
[Presentation] Influence of high-dose taurine treatment in fatty liver disease models2017
- Author(s)
  A. Funaki, C. Fukuhara, Y. Sumiya, S. Yoahimasa, M. Miyata
- Organizer
  Symposium between National Fisheries University and Pukyong Natinal University
- Data Source
  KAKENHI-PROJECT-16K00904
[Presentation] タウリンによる肝機能改善作用の解析-リトコール酸誘発性肝障害の防御-2017
- Author(s)
  舩木萌浩、杉浦義正、宮田昌明
- Organizer
  日本農芸化学会中四国支部　第48回講演会
- Data Source
  KAKENHI-PROJECT-16K00904
[Presentation] 魚油摂取による脂肪性肝疾患モデルであるFxr欠損マウスの肝機能改善作用2016
- Author(s)
  宮田昌明、新野耕平、杉浦義正
- Organizer
  平成28年度日本水産学会秋季大会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-16K00904
[Presentation] Fish oil treatment improves hepatic function in Fxr-null mice2016
- Author(s)
  Shinno K ,Sugiura Y, and Miyata M
- Organizer
  2017 Joint Internatioal Symposium between PNU and NFU
- Place of Presentation
  Shimonoseki
- Data Source
  KAKENHI-PROJECT-16K00904
[Presentation] SREBP-2はヒト消化管由来細胞でFGF19のFXR依存的な転写を負に調節する2014
- Author(s)
  宮田昌明、畑竜也、山添康、吉成浩一
- Organizer
  日本農芸化学会2014年会
- Place of Presentation
  東京
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-24659064
[Presentation] SREBP-2はヒト消化管由来細胞でFGF19のFXR依存的な転写を負に調節する2014
- Author(s)
  宮田昌明、畑竜也、山添康、吉成浩一
- Organizer
  日本農芸化学会　2014年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659064
[Presentation] LS174T細胞のFXRシグナルは活性型SREBP2により抑制的に調節される2013
- Author(s)
  宮田昌明、畑竜也、山添康、吉成浩一
- Organizer
  日本薬学会第133回年会
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24659064
[Presentation] 腸内細菌による胆汁酸代謝変換は回腸の胆汁酸吸収輸送担体の発現を制御する2013
- Author(s)
  宮田昌明、山川泰輝、林謙次郎、吉成浩一、山添康
- Organizer
  2013年度日本農芸化学会合同広島大会
- Place of Presentation
  広島
- Year and Date
  2013-09-06
- Data Source
  KAKENHI-PROJECT-24659064
[Presentation] 腸内細菌による胆汁酸代謝変換は回腸の胆汁酸吸収輸送担体の発現を制御する2013
- Author(s)
  宮田昌明、山川泰輝、林　謙次郎、吉成浩一、山添　康
- Organizer
  2013年度　日本農芸化学会　合同広島大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24659064
[Presentation] 消化管FGF15/19シグナルによる肝機能の調節薬物代謝・分子毒性学2013
- Author(s)
  宮田昌明
- Organizer
  仙台セミナーー基礎研究から創薬・臨床へー
- Place of Presentation
  仙台
- Year and Date
  2013-02-16
- Data Source
  KAKENHI-PROJECT-24659064
[Presentation] FGF19は非アルコール性脂肪性肝疾患モデルFxr欠損マウスの病態を改善する2013
- Author(s)
  宮田　昌明,松澤　瞳,境田　裕美,山添　康,吉成　浩一
- Organizer
  2013　環境トキシコロジーフォーラム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24659064
[Presentation] FGF19は非アルコール性脂肪性肝疾患モデルFxr欠損マウスの病態を改善する2013
- Author(s)
  宮田昌明, 松澤瞳, 境田裕美, 山添康, 吉成浩一
- Organizer
  2013環境トキシコロジーフォーラム
- Place of Presentation
  福岡
- Year and Date
  2013-09-14
- Data Source
  KAKENHI-PROJECT-24659064
[Presentation] Antibacterial drug treatment causes enhanced levels of hepatic bile acid through alteration of ileal bile acid transporter expression2012
- Author(s)
  M. Miyata, H. Yamakawa, Y. Yamazoe
- Organizer
  The 6^<th> International Congress of Asian Society of Toxicology
- Place of Presentation
  Sendai, Japan
- Year and Date
  2012-07-20
- Data Source
  KAKENHI-PROJECT-24659064
[Presentation] 腸内細菌による胆汁酸の代謝変換がユビキチン/ライソゾーム分解系を介する回腸Asbtの抑制的な発現調節に関与する2012
- Author(s)
  宮田昌明、山川泰輝、林謙次郎、吉成浩一、山添康
- Organizer
  第27回日本薬物動態学会
- Place of Presentation
  東京
- Year and Date
  2012-11-22
- Data Source
  KAKENHI-PROJECT-24659064
[Presentation] 肝胆汁酸合成の抑制に関与するマウス回腸FGF15発現の新規調節機序2012
- Author(s)
  栗林秀明、宮田昌明、山川泰輝、吉成浩一、山添康
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Year and Date
  2012-07-17
- Data Source
  KAKENHI-PROJECT-24659064
[Presentation] 回腸胆汁酸トランスポーターASBTの発現は腸内細菌代謝型胆汁酸シグナルに依存したユビキチン/タンパク質分解系で負に調節される2012
- Author(s)
  宮田昌明、山川泰輝、林謙次郎、山添康
- Organizer
  第34回胆汁酸研究会
- Place of Presentation
  名古屋
- Year and Date
  2012-12-01
- Data Source
  KAKENHI-PROJECT-24659064
[Presentation] 腸内細菌による胆汁酸代謝を介する回腸Asbtの発現調節2012
- Author(s)
  宮田昌明, 他3名
- Organizer
  日本薬学会第132回年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 抗菌薬投与による肝内胆汁酸レベルの上昇の機序―回腸胆汁酸吸収トランスポーター発現の解析2012
- Author(s)
  宮田昌明、山川泰輝、山添康
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Year and Date
  2012-07-17
- Data Source
  KAKENHI-PROJECT-24659064
[Presentation] Role of bile acid conjugation/deconjugation for ileal fibroblast growth factor 15 expression in mice2011
- Author(s)
  Hideaki Kuribayashi, Hiroki Yamakawa, Masaaki Miyata and Yasushi Yamazoe
- Organizer
  4th Asia-Pacific Regional ISSX Meeting
- Place of Presentation
  Tainan, Taiwan
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 肝内胆汁酸レベルの抑制に関与するヒト回腸FGF19の転写調節機序2011
- Author(s)
  畑竜也、宮田昌明、吉成浩一、山添康
- Organizer
  第38回日本トキシコロジー学会
- Place of Presentation
  横浜
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 胆汁酸動態の調節因子であるヒト回腸FGF19は複数のFXR応答領域を介して転写調節される2011
- Author(s)
  宮田昌明、畑竜也、加川建弘、山添康
- Organizer
  第33回胆汁酸研究会
- Place of Presentation
  大阪
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 新規胆汁酸-FXR応答配列を介したヒトFGF19遺伝子の転写活性化2011
- Author(s)
  畑竜也、宮田昌明、吉成浩一、山添康
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 胆汁酸代謝を介する腸内細菌による回腸エンドクラインホルモンFGF15の発現調節2011
- Author(s)
  宮田昌明, 他3名
- Organizer
  第131回日本薬学会年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] 胆汁うつ滞モデルのリトコール酸誘発性肝障害と脂肪酸代謝2011
- Author(s)
  宮田昌明, 他1名
- Organizer
  第38回日本トキシコロジー学会
- Place of Presentation
  横浜(招待講演)
- Year and Date
  2011-07-12
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] Fxr欠損マウスにおいてFGF19は肝脂質レベルを低下させる2011
- Author(s)
  松澤瞳、境田裕美、宮田昌明, 山添康
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 胆汁酸代謝を介する腸内細菌による回腸エンドクラインホルモンFGF15の発現調節2011
- Author(s)
  宮田昌明、栗林秀明、山川泰輝、山添康
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 抗菌薬投与による肝内胆汁酸レベルの上昇の機序-回腸分泌FGF15発現の解析2011
- Author(s)
  宮田昌明、栗林秀明、山川泰輝、山添康
- Organizer
  第38回日本トキシコロジー学会
- Place of Presentation
  横浜
- Year and Date
  2011-07-12
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 肝胆汁酸合成の調節における腸内細菌によるアミノ酸抱合型コール酸の脱抱合の役割2011
- Author(s)
  宮田昌明, 他3名
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 腸内細菌による胆汁酸脱抱合は、回腸FGF15発現誘導に関与し、肝胆汁酸合成を抑制する2011
- Author(s)
  栗林秀明、宮田昌明、山川泰輝、山添康
- Organizer
  第10回次世代を担う若手ファーマバイオフォーラム
- Place of Presentation
  仙台
- Year and Date
  2011-10-09
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] Fxr欠損マウスにおいてFGF19は肝脂質レベルを低下させる2011
- Author(s)
  松澤瞳、境田裕美、宮田昌明, 山添康
- Organizer
  第50回日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2011-10-30
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] Enterobacteria modulate intestinal bile acid transport and homeostasis through apical sodium-dependent bile acid transporter expression2011
- Author(s)
  Masaaki Miyata, 他4名
- Organizer
  4^<th> Asia-Pacific Regional ISSX Meeting
- Place of Presentation
  Tainan, Taiwan
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 胆汁酸代謝を介する腸内細菌による同腸エンドクラインホルモンFGF15の発現調節2011
- Author(s)
  宮田昌明, 他3名
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] マウス回腸におけるFGF15発現調節に対する胆汁酸抱合2010
- Author(s)
  栗林秀明、山川泰輝、宮田昌明、山添康
- Organizer
  脱抱合の役割第32回胆汁酸研究会
- Place of Presentation
  仙台
- Year and Date
  2010-11-06
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] Enterobacteria alter bile acid homeostasis through FXR-FGF15/19 system 18th Microsomal Drug Oxidation2010
- Author(s)
  Yasushi Yamazoe, Yuki Takamatsu, Hideaki Kuribayashi, Hiroki Yamakawa and Masaaki Miyata
- Place of Presentation
  Beijin, Chaina
- Year and Date
  2010-05-18
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 抗菌薬投与は胆汁酸トランスポーター、合成酵素の発現亢進を介して胆汁酸ホメオスタシスを変動させる2010
- Author(s)
  宮田昌明、山川泰輝、栗林秀明、濱津真由美、高松裕樹、山添康
- Organizer
  第25回日本薬物動態学会
- Place of Presentation
  大宮
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] 腸内細菌は回腸ASBT 発現を介して消化管の胆汁酸吸収を調節する2010
- Author(s)
  山川泰輝、宮田昌明、栗林秀明、高松裕樹、濱津真由美、山添康
- Organizer
  第25回日本薬物動態学会
- Place of Presentation
  大宮
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] 腸内細菌は胆汁酸代謝を介した回腸ASBT発現抑制により宿主の胆汁酸吸収を制御する2010
- Author(s)
  山川泰輝、栗林秀明、宮田昌明、山添康
- Organizer
  第32回胆汁酸研究会
- Place of Presentation
  仙台
- Year and Date
  2010-11-06
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal FGF15 expression2010
- Author(s)
  Masaaki Miyata, 他3名
- Organizer
  2010 Experimental Biology
- Place of Presentation
  Anaheim, USA
- Year and Date
  2010-04-26
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] アンピシリン投与はマウス回腸の胆汁酸吸収トランスポータータンパク含量を増加させ、糞中胆汁酸排泄を低下させる2010
- Author(s)
  宮田昌明、山川泰輝、濱津真由美、高松裕樹、山添康
- Organizer
  日本薬学会第130回年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal FGF 15 expression.2010
- Author(s)
  Masaaki Miyata, 他3名
- Organizer
  2010 Experlmental Biology
- Place of Presentation
  Anaheim, USA
- Year and Date
  2010-04-26
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] 抗菌薬による腸内細菌叢の変動は回腸胆汁酸吸収トランスポーターASBTの発現上昇に関与する2010
- Author(s)
  宮田昌明、山川泰輝、栗林秀明、濱津真由美、山添康
- Organizer
  第37回日本トキシコロジー学会年会
- Place of Presentation
  宜野湾
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] 抗菌薬投与は胆汁酸トランスポーター、合成酵素の発現亢進を介して胆汁酸ホメオスタシスを変動させる2010
- Author(s)
  宮田昌明、山川泰輝、栗林秀明、濱津真由美、高松裕樹、山添康
- Organizer
  第25回日本薬物動態学会
- Place of Presentation
  大宮
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] FGf15/19は脂肪肝/高脂血症モデルのFxr欠損マウスの肝脂質レベルを低下させる2010
- Author(s)
  宮田昌明、境田裕美、松澤瞳、山添康
- Organizer
  フォーラム2010衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 腸内細菌は、消化管におけるFGF15の発現に関与し、肝脂質代謝を変動させる2010
- Author(s)
  栗林秀明、山川泰輝、高松裕樹、宮田昌明、山添康
- Organizer
  日本薬学会第130回年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] Administration of ampicillin increases ileal Asbt protein amounts resulting in reduction of fecal bile acid excretion in mice.2010
- Author(s)
  山添康, 高松裕樹, 濱津真由美, 宮田昌明
- Organizer
  2010 Experimental Biology
- Place of Presentation
  Anaheim USA
- Year and Date
  2010-04-27
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] Enterobacteria alter bile acid homeostasis through FXR-FGF15/19 system2010
- Author(s)
  山添康, 高松裕樹, 栗林秀明, 山川泰輝, 宮田昌明
- Organizer
  Microsomal Drug Oxidation
- Place of Presentation
  Beijin, Chaina
- Year and Date
  2010-05-18
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal FGF15 expression2010
- Author(s)
  Masaaki Miyata, Yuki Takamatsu, Hideaki Kuribayashi and Yasushi Yamazoe
- Organizer
  2010 Experimental Biology
- Place of Presentation
  Anaheim USA
- Year and Date
  2010-04-27
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 前立腺癌治療薬flutamide誘発肝障害の機序 : N-水酸化代謝物とGSH2009
- Author(s)
  大渕雅人、宮田昌明、長井大地、山添康
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19390037
[Presentation] FGF19は高脂血症モデルFXR欠損型マウスにおいて肝の脂質動態を変動させる2009
- Author(s)
  境田裕美、宮田昌明、山添康
- Organizer
  第24回日本薬物動態学会
- Place of Presentation
  京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 腸内細菌ーFGF系による肝胆汁酸レベルの調節2009
- Author(s)
  宮田昌明、高松裕樹、山添康
- Organizer
  第36回日本トキシコロジー学会年会
- Place of Presentation
  盛岡
- Year and Date
  2009-07-08
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] 消化管FGF15の発現変動と胆汁酸組成2009
- Author(s)
  宮田昌明, 他4名
- Organizer
  第31回胆汁酸研究会
- Place of Presentation
  東京
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] FGF19は高脂血症モデルFxr欠損型マウスにおける肝の脂質動態を変動させる2009
- Author(s)
  境田裕美、宮田昌明、山添康
- Organizer
  第48回日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] アンピシリン投与による肝内胆汁酸濃度上昇における消化管と肝臓の寄与2009
- Author(s)
  濱津真由美、高松裕樹、宮田昌明、山添康
- Organizer
  第48回日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] 前立腺癌治療薬flutamide誘発肝障害の機序 : N-水酸化代謝物とGSH2009
- Author(s)
  宮田昌明(他3名)
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19390037
[Presentation] 消化管FGF15の発現変動と胆汁酸組成2009
- Author(s)
  宮田昌明、栗林秀明、山川泰輝、高松裕樹、山添康
- Organizer
  第31回胆汁酸研究会
- Place of Presentation
  東京
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 腸内細菌-FGF系による肝胆汁酸レベルの調節2009
- Author(s)
  宮田昌明, 他2名
- Organizer
  第36回日本トキシコロジー学会年会
- Place of Presentation
  盛岡
- Year and Date
  2009-07-08
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] 腸内細菌-FGF系による肝胆汁酸レベルの調節2009
- Author(s)
  宮田昌明、高松裕樹、山添康
- Organizer
  第36回日本トキシコロジー学会年会
- Place of Presentation
  盛岡
- Year and Date
  2009-07-08
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 抗菌薬の投与は回腸FGF15の発現低下を介して一次胆汁酸合成を増加させる2009
- Author(s)
  宮田昌明, 他3名
- Organizer
  第24回日本薬物動態学会
- Place of Presentation
  京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] 抗菌薬の投与は回腸FGF15の発現低下を介して一次胆汁酸合成を増加させる2009
- Author(s)
  宮田昌明、高松裕樹、栗林秀明、山添康
- Organizer
  第24回日本薬物動態学会
- Place of Presentation
  京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] farnesoid Xreceptor(FXR)の欠損は、肝内胆汁酸濃度の上昇を引き起こし、酸化ストレスの生成を促進する2008
- Author(s)
  野本眞博、宮田昌明、山添康
- Organizer
  第35回日本トキシコロジー学会学術年会
- Place of Presentation
  東京
- Year and Date
  2008-06-26
- Data Source
  KAKENHI-PROJECT-19390037
[Presentation] 核内受容体farnesoid X receptor(FXR)の欠損は、肝内胆汁酸濃度の上昇を引き起こし酸化ストレスの生成を促進する2008
- Author(s)
  宮田昌明、野本眞博、山添康
- Organizer
  第37日本環境変異原学会
- Place of Presentation
  沖縄
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-19390037
[Presentation] 抗菌薬投与による肝内胆汁酸濃度の上昇と回腸FGF15の発現抑制2008
- Author(s)
  宮田昌明(他2名)
- Organizer
  第30回胆汁酸研究会
- Place of Presentation
  広島
- Year and Date
  2008-10-18
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] リトコール酸誘発肝障害の防御機序における生体内リン脂質2008
- Author(s)
  外舘史祥、宮田昌明、山添康
- Organizer
  第47回日本薬学会東北支部会
- Place of Presentation
  盛岡
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-19390037
[Presentation] 前立腺癌治療薬flutamide誘発肝障害の機序 : N-水酸化代謝物とGSH2008
- Author(s)
  宮田昌明、大渕雅人、長井大地、山添康
- Organizer
  第35回日本トキシコロジー学会学術年会
- Place of Presentation
  東京
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-19390037
[Presentation] アンピシリン併用により生ずるコール酸誘発肝障害と胆汁酸動態2008
- Author(s)
  高松裕樹、宮田昌明、山添康
- Organizer
  第35回日本トキシコロジー学会学術年会
- Place of Presentation
  東京
- Year and Date
  2008-06-26
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] 前立腺癌治療薬flutamide誘発肝障害の機序 : N-水酸化代謝物とGSH2008
- Author(s)
  宮田昌明(他3名)
- Organizer
  第35回日本トキシコロジー学会
- Place of Presentation
  東京
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-19390037
[Presentation] 核内受容体FXRの欠損は、肝内胆汁酸濃度の上昇を引き起こし、酸化ストレスの生成を促進する2008
- Author(s)
  宮田昌明(他2名)
- Organizer
  第5回東日本胆汁酸研究会
- Place of Presentation
  東京
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] 抗生物質投与による肝内胆汁酸濃度上昇とその機序2008
- Author(s)
  高松裕樹、宮田昌明,山添康
- Organizer
  第47回日本薬学会東北支部会
- Place of Presentation
  盛岡
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] 脂質とFXR control2008
- Author(s)
  宮田昌明(他3名)
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-20590137
[Presentation] 網羅的遺伝子発現解析からのコール酸誘発肝障害2007
- Author(s)
  宮田昌明、野本眞博、松田良樹、小原有弘、横川伸也、二宮真一、山添康
- Organizer
  第34回日本トキシコロジー学会学術年会
- Place of Presentation
  東京
- Year and Date
  2007-06-29
- Data Source
  KAKENHI-PROJECT-19390037
[Presentation] コール酸誘発肝障害モデルにおけるME3738の有効性-酸化ストレスの防御因子と胆汁中コレステロール及び胆汁酸排泄促進2007
- Author(s)
  野本眞博、宮田昌明、黒沢亨、山添康
- Organizer
  第34回日本トキシコロジー学会学術年会
- Place of Presentation
  東京
- Year and Date
  2007-06-29
- Data Source
  KAKENHI-PROJECT-19390037
[Presentation] Involvements of N-hydroxylation of flutamde metabolite and hepatic GSH depletion in flutamide-induced hepatotoxicity2007
- Author(s)
  M. Ohbuchi, M. Miyata, D. Nagai, M. Shimada, K. Yoshinari and Y. Yamazoe
- Organizer
  8^<th> ISSX meeting
- Place of Presentation
  Sendai
- Year and Date
  2007-10-10
- Data Source
  KAKENHI-PROJECT-19390037
[Presentation] ME3738 mediated enhancement of biliary cholesterol excretion at high hepatic bile acid levels stimulates biliary bile acid excretion without altering liver Bsep protein levels2007
- Author(s)
  M. Nomoto, M. Miyata, T. Kurosawa and Y. Yamazoe
- Organizer
  8^<th> ISSX meeting
- Place of Presentation
  Sendai
- Year and Date
  2007-10-10
- Data Source
  KAKENHI-PROJECT-19390037
[Presentation] 消化管FGF15/19シグナルによる肝機能の調節
- Author(s)
  宮田昌明
- Organizer
  薬物代謝・分子毒性学仙台セミナーー基礎研究から創薬・臨床へー
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-24659064

1. YAMAZOE Yasushi (00112699)

# of Collaborated Projects: 8 results

# of Collaborated Products: 46 results
2. YOSHINARI Kouichi (60343399)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
3. NAGATA Kiyoshi (80189133)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
4. FURUKAWA Masayuki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 児玉進 (20621460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. GONZALEZ F. J.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Miyata Masaaki 宮田 昌明

MIYATA Masaaki 宮田 昌明

宮田 昌明 ミヤタ マサアキ

Research Projects

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Co-Researchers

Preventive mechanisms of dyslipidemia by bile acid-mediated gastrointestinal signal due to marine food componentsPrincipal Investigator

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A new dietary preventive strategy targeting regulation of gastrointestinal bile acid metabolism for fatty liver diseasePrincipal Investigator

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The protection of fatty liver disease by fish-derived dietary habit targeted to intestinal bile acid controlPrincipal Investigator

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Principal Investigator

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Regulation of glucose and lipid metabolism through specific receptor-responsive FGF19 proteinPrincipal Investigator

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Principal Investigator

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Role of ileal bile acid absorption on regulation of serum cholesterol levelsPrincipal Investigator

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Novel protective mechanisms for cholestatic hepatotoxicity-application to drug improving hepatic functionPrincipal Investigator

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Miyata Masaaki 宮田昌明

MIYATA Masaaki 宮田昌明

宮田昌明ミヤタマサアキ