Yasuda Motoaki 安田元昭

… Alternative Names

YASUDA Motoaki 安田元昭

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Researcher Number	90239765
Other IDs
External Links
Affiliation (Current)	2023: 北海道大学, 歯学研究院, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2022: 北海道大学, 歯学研究院, 准教授 2016 – 2017: 北海道大学, 歯学研究科, 准教授 2011 – 2015: 北海道大学, 歯学研究科(研究院), 准教授 2014: 北海道大学, 大学院歯学研究科, 准教授 2007 – 2012: Hokkaido University, Graduate School of Dentistry, Associate Professor … More 2006: Hokkaido Univ., Grad. Sch. of Dent. Med, Asso. Prof., 大学院歯学研究科, 助教授 2005: 北海道大学, 大学院・歯学部研究科, 助教授 2001 – 2005: Hokkaido Univ. Grad. School of Dent. Med. Asso. Prof., 大学院・歯学研究科, 助教授 2003: Hokkaido University, Hokkaido University, Graduate shool of Dentai medicine, assisant professor 2000: Hokkaido Univ., Graduate School of Dental Medicine, Inst., 大学院・歯学研究科, 助手 1993 – 1999: 北海道大学, 歯学部, 助手 1994 – 1995: 北海道大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator 病態科学系歯学(含放射線系歯学) / Basic Section 57060:Surgical dentistry-related / Pathobiological dentistry/Dental radiology / Morphological basic dentistry Except Principal Investigator Surgical dentistry / Surgical dentistry / Radiation science / 補綴理工系歯学 / 補綴理工系歯学 / Morphological basic dentistry … More / 病態科学系歯学(含放射線系歯学) / Prosthetic dentistry / Basic Section 57060:Surgical dentistry-related / Pathobiological dentistry/Dental radiology / Morphological basic dentistry / Radiation science Less
Keywords	Principal Investigator 口腔がん / DNA array / アデノウイルス / アポトーシス / 非翻訳領域 / DNAアレイ / HPV / Radiation / Apoptosis / 自然免疫 … More / 放射線感受性 / ヒトパピローマウイルス / 幹細胞 / オートファジー / がん幹細胞 / ＵＴＲ / tripartite leader / adenovirus / UTR / AU rich element / RNA結合タンパク質 / 翻訳促進 / Hu　タンパク質 / Transcription factor / Innate immune / Adenovirus / TLR / 転写因子 / cell removal system / apoptosis / radiation / QSRP-11 / MRC5 / QRSP-11 / 移植腫瘍 / 細胞除去機構 / 放射線 / Bangladesh / Baccal cancer / 分子疫学 / メンブレンアレイ / バングラデッシュ / バングラディッシュ / 頬粘膜がん / Caspase / 放射線照射 / がん抑制遺伝子 / 炎症 / 口腔発がん / ARE / NF-kB / 実験腫瘍学 / growth factor / 口腔扁平上皮がん / ミトコンドリア / HGF / カルボケラチン / P53 / nm23 / 口腔癌 … More Except Principal Investigator E1AF / p53 / 骨芽細胞 / アデノウイルス / apoptosis / アポトーシス / E4orf6 / チタン / 溶解 / 腫瘍 / osteoblast / 遺伝子導入 / マクロファージ / MMP / repopulation / 生体適合性 / 骨髄細胞 / カーボンナノチューブ / オステオポンチン / BMP / デキサメサゾン / 口腔扁平上皮がん / 腫瘍溶解ウイルス / ARE-mRNA / ATF5 / CD14 / Dectin-1 / DC-SIGN / FSL-1 / Toll-like receptor / 口腔がん / Bnip3 / オステオカルシン / 細胞周期 / p21 / osteopontin / gene transfection / HGF / Ad12E1A / 放射線 / 放射線治療 / デンタルインプラント / インプラント / オッセオインテグレーション / 骨形成 / 生体材料 / 細胞形態 / irradiation / 放射線生物学 / ポリ乳酸 / 表面修飾 / b-FGF / 遺伝子発現 / DNAマイクロチップ / 骨髄幹細胞 / GM-CSF / AU-rich element / センサー / GFP / トランスレーショナルリサーチ / 癌 / transcription factor / radiosensitivity / 転写因子 / 放射線感受性 / Th2 response / phagocytosis / TLR2 / 大腸菌由来LPS / リポペプチドFSL-1 / 微生物貪食 / Th2応答 / Toll様受容体(TLR) / 細菌貧食 / osteogenesis / macrophage / biocompatibilit / bulk material / cell culture / scaffold / carbon nanotubes / 濾過膜 / 骨再生 / GBR / DNAマイクロアレイ / 表面処理 / カーボンナノファイバー / 固化体 / 細胞培養 / スキャホールド / radiation therapy / cancer invasion / cell cycle / DNA array / 癌浸潤 / Leucine-rich repeats / lipopeoteins / lipopeptides / Toll-like receptor 2 / Toll様受容体 / ペプチドグリカン / ロイシンリッチリピート / リポタンパク質 / リポペプチド / Toll様受容体2 / ets oncogene / Gene therapy / Protein-protein interaction / Invasion and metastasis / Immortalization / Oral carcinoma / 転移 / 浸潤 / TIMP / Etsがん遺伝子 / 遺伝子治療 / タンパク相互作用 / 浸潤転移 / 細胞不死化 / Transmembrane domain / Apoptosis / 膜貫通ドメイン / osseointegration / bone marrow cell / dental implant / daibetes / osteonectin / 細胞接着能 / インプテント / 細胞接着強度 / 細胞接着率 / 糖尿病 / オステオネクチン / promoter activity / adenvirus vector / 転写調節領域 / survivin / プロモーター活性 / アデノウイルスベクター / immediate implant / cancellous bone / CM-chitin / β-TCP / calcium phosphate cement / 多孔質 / 骨補填材 / 抜歯即時インプラント / 海綿骨 / CMキチン / β-三リン酸カルシウム / リン酸カルシウムセメント / cell cycle regulation / 細胞周期調節 / cytokine / Clinicopatogical finding / Sjogren's syndrome / シェーグレン症候群 / サイトカイン / 唾液腺障害 / シェーグレン症候 / adhesive activity / biomaterials / α-3リン酸カルシウム / ハイドロキシアパタイト / 骨芽細胞様細胞 / 接着能 / Lymph node metastasis / VEGF / Oral squamous cell carcinoma / ets transcription factor E1AF / リンパ節転移 / 血管内皮細胞増殖因子 / 細胞外基質分解酵素 / 転写因子E1AF / 転写調節 / アデノウィルスベクター / E1AFプロモーター / ウイルスベクター / DNA microarray / RNAサブトラクション法 / yeast two hybrid / ets がん遺伝子 / EIAF / 結合タンパク / etsがん遺伝子群転写因子 / DNAチップ / GENETICINSTABILITY / DNE REPAIR / P53 GENE / BETEL QUID / PRECANCEROUSLESION / ORAL SCC / スリランカ / 遺伝子変異 / 口腔癌 / 遺伝子の不安定性 / 遺伝子の修復 / p53遺伝子 / 噛みタバコ / 前癌病変 / 口腔扁平上皮癌 / Cadherin Molecule / Morphorogic preservation / Cell adhesion / Radiation / カドヘリン / 形態温存 / 細胞接着因子 / HIF/alpha / 低酸素 / translation / trascription / HIF-1a / HIF / UTR / 骨改造 / 骨関連タンパク / 免疫組織化学 / 即時インプラント / リモデリング / 咬合 / マイクロアレイ / 組織化学 / 即時埋入 / 咬合負荷 / グロースファクター / カーボンナノホーン / 陽極酸化チタン / 3次元スキャホールド / 構造変化 / 長期安定性 / カーボンナノ物質 / スタチン / カーボンナノマテリアル / 免疫細胞 / ビスホスフォネート / 免疫 / 顎骨壊死 / ビスホスホネート / 細胞運動 / TGFB-1 / Radiotherapy / cell movement / cancer stem cell / radiation / HIF1-alpha / mitosis / p16 / 炎症反応 / 初期接着 / コラーゲン / 三次元スキャホールド / アルカリフォスファターゼ / 歯根膜再生 / XII型コラーゲン / RNA / 幹細胞 / 歯根膜 / フォリスタチン / 浸潤・転移 / ラフトカルチャー / マトリックスメタロプロテアーゼ / フローサイトメトリー / インテグリン / 歯周疾患 / ダウン症候群 Less

Development of oncolytic virus that induces tumor immunity for oral cancers
- Principal Investigator
  
  東野史裕
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Hokkaido Information University
難治性口腔がんに有効な腫瘍溶解ウイルスの開発Principal Investigator
- Principal Investigator
  
  安田元昭
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Hokkaido University
Oncolytic virus targeting oral cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  YASUDA MOTOAKI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Hokkaido University
Applied of RNA stabilization system-based oncolytic virus to oral cancer
- Principal Investigator
  
  Higashino Fumihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hokkaido University
Analysis of comprehensive gene regulation systems in oral cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  YASUDA MOTOAKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Hokkaido University
Development of cancer sensor by utilizing oncolytic virus
- Principal Investigator
  
  Higashino Fumihiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Hokkaido University
がん細胞は自身の生存をかけ放射線域を逃れるべく上皮間葉移行をなしうるか
- Principal Investigator
  
  西岡健
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Investigation of mechanism on obstruction of osseointegration caused by micro movement by occlusion
- Principal Investigator
  
  ATSURO Yokoyama
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Prosthetic dentistry
- Research Institution
  Hokkaido University
Development of new oncolytic adenovirus
- Principal Investigator
  
  Higashino Fumihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Hokkaido University
Reconstruction of Jaw Bone with 3 dimension scaffold treated by functionalized carbon nano-material
- Principal Investigator
  
  YOKOYAMA Atsuro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Prosthetic dentistry
- Research Institution
  Hokkaido University
Cross-talk between innate-immunological responses and oral oncogenesis.Principal Investigator
- Principal Investigator
  
  YASUDA Motoaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Hokkaido University
Immunological approaches to the mechanisms of bisphosphonate-related osteonecrosis of the jaw
- Principal Investigator
  
  DEYAMA Yoshiaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hokkaido University
The secret of radiation-surviving cell : multidisciplinary approach to eradicate cancer
- Principal Investigator
  
  NISHIOKA Takeshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Oral Tissue Reconstruction with 3D Scaffolds and Surface Modification Using Carbon Nanotubes
- Principal Investigator
  
  YOKOYAMA Atsuro
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Hokkaido University
Radiation-induced highly-malignant cancer cells: the mechanism and how to deal with it
- Principal Investigator
  
  NISHIOKA Takeshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Cross-talk between viral. infection and bacterial infection in oral regionPrincipal Investigator
- Principal Investigator
  
  YASUDA Motoaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hokkaido University
Roles of Toll-like receptors in bacterial phagocytosis
- Principal Investigator
  
  SHIBATA Ken-ichiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Hokkaido University
Molecular Mechanisms and Visualization of Radiation-induced tumor cell repopulation
- Principal Investigator
  
  NISHIOKA Takeshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  HOKKAIDO UNIVERSITY
Development of regenerative therapy for jaw bone using scaffold with carbon nanotubes.
- Principal Investigator
  
  YOKOYAMA Atsuro
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Hokkaido University
歯根膜再生・人工歯根膜開発を目的とした歯根膜幹細胞の分化における遺伝子発現の解明-DNAマイクロチップを用いた歯根膜幹細胞の遺伝子発現の検索-
- Principal Investigator
  
  横山敦郎
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  補綴理工系歯学
- Research Institution
  Hokkaido University
Studies on recognition mechanism of oral microbes-derived lipopeptides by Toll-like receptors
- Principal Investigator
  
  SHIBATA Ken-ichiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hokkaido University
骨芽細胞への分化で発現する遺伝子の導入細胞を用いた顎骨再生療法の開発
- Principal Investigator
  
  KAWASAKI Takao
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Hokkaido University
Research on factors involved in prognosis of oral carcinoma.
- Principal Investigator
  
  SHINDOH Masanobu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  HOKKAIDO UNIVERSITY
The removal system at irradiated apoptotic cellsPrincipal Investigator
- Principal Investigator
  
  YASUDA Motoaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Hokkaido Universty
With the aim of expansion of the application of dental implants for the aged person and the patient who have systemic disease : the development of dental implants combined with the cell tranfected gene of bone related protein
- Principal Investigator
  
  YOKOYAMA Atsuro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Hokkaido University
Induction of apoptosis in oral squamous cell carcinoma by activating caspase
- Principal Investigator
  
  TOTSUKA Yasunori
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hokkaido University
Molecular etiological study on buccal carcinogenesis in BangladeshPrincipal Investigator
- Principal Investigator
  
  YASUDA Motoaki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Hokkaido University
Analyses of relation between cytokine production, apoptosis and clinicopathological findings in Sjogren's syndrom patients
- Principal Investigator
  
  HIROSHI Fukkuda
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hokkaido University
The role of E1AF, an ets-oncogene family tranascription factor in cell cycle regulation.
- Principal Investigator
  
  TOTSUKA Yasunori
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hokkaido University
With the aim of early convalescence of the occlusal function in the immediate implant after tooth extraction :
- Principal Investigator
  
  YOKOYAMA Atsuro
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  HOKKAIDO UNIVERSITY
Caspase cascades which activated by ionizing irradiationPrincipal Investigator
- Principal Investigator
  
  YASUDA Motoaki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Hokkaido University
Gene therapy for oral squamous cell carcinoma targeting tumor specific promoter activation
- Principal Investigator
  
  SHINDOH Masanobu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Hokkaido University
An atempt of gene therapy for oral squamous cell carcinoma
- Principal Investigator
  
  SHINDOH Masanobu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hokkaido University
Relationship between expression of E1AF and histological malignancies of oral squamous cell carcinoma
- Principal Investigator
  
  ONO Mitsunobu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  HOKKAIDO UNIVERSITY
Effects on gene expression of bone and cell-adhesive proteins by biomaterials
- Principal Investigator
  
  YOKOYAMA Atsuro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Hokkaido University
口腔偏平上皮がんの放射線感受性に関与する遺伝子の同定Principal Investigator
- Principal Investigator
  
  安田元昭
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Hokkaido University
Identification of targetgenes of E1AF using two hybrid system
- Principal Investigator
  
  SHINDO Masanobu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  HOKKAIDO UNIVERSITY
ABNORMALITIES IN DNA REPAIR AND GENOMIC IMPRINTING IN ORAL PRECANCEROUS LESIONS.
- Principal Investigator
  
  CHIBA Itsuo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  HOKKAIDO UNIVERSITY
ダウン症候群児の歯周疾患発症における細胞接着因子の役割
- Principal Investigator
  
  工藤真幸
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Hokkaido University
ラフトカルチャーによる口腔がんの浸潤・転移活性の評価と転写因子E1A-Fとの関連
- Principal Investigator
  
  SHINDO Masanobu
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hokkaido University
HPV E6/E7遺伝子とapoptosisに関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  安田元昭
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Hokkaido University
Molecular biology of morphological preservation of radiotherapy
- Principal Investigator
  
  SHIRATO Hiroki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  HOKKAIDO UNIVERSITY
口腔扁平上皮癌の放射線感受性に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  安田元昭
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Hokkaido University

[Journal Article] Conditionally Replicative Adenovirus Controlled by the Stabilization System of AU-Rich Elements Containing mRNA2020
- Author(s)
  Mikawa Yohei、Towfik Alam Mohammad、Hossain Elora、Yanagawa-Matsuda Aya、Kitamura Tetsuya、Yasuda Motoaki、Habiba Umma、Ahmed Ishraque、Kitagawa Yoshimasa、Shindoh Masanobu、Higashino Fumihiro
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 5 Pages: 1205-1205
- DOI
  10.3390/cancers12051205
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10326, KAKENHI-PROJECT-20K09900, KAKENHI-PROJECT-17H04401, KAKENHI-PROJECT-18K09737, KAKENHI-PROJECT-19K19221
[Journal Article] 口腔扁平上皮がん細胞におけるELAVL2の発現2020
- Author(s)
  畑中知之、三河洋平、東野史裕、鄭漢忠、安田元昭
- Journal Title
  
  北海道歯学雑誌
  
  Volume: 40 Pages: 79-86
- NAID
  120006826284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04401
[Journal Article] Advantages of Using Paclitaxel in Combination with Oncolytic Adenovirus Utilizing RNA Destabilization Mechanism2020
- Author(s)
  Hossain Elora、Habiba Umma、Yanagawa-Matsuda Aya、Alam Arefin、Ahmed Ishraque、Towfik Alam Mohammad、Yasuda Motoaki、Higashino Fumihiro
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 5 Pages: 1210-1210
- DOI
  10.3390/cancers12051210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09900, KAKENHI-PROJECT-17H04401, KAKENHI-PROJECT-19K19221
[Journal Article] The neural ELAVL protein HuB enhances endogenous proto-oncogene activation.2019
- Author(s)
  Hatanaka T, Higashino F, Tei K, Yasuda M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 517(2) Issue: 2 Pages: 38-45
- DOI
  10.1016/j.bbrc.2019.07.089
- NAID
  120006886034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09737, KAKENHI-PROJECT-17K11660, KAKENHI-PROJECT-17H04401
[Journal Article] Oncolytic potential of an E4-deficient adenovirus that can recognize the stabilization of AU-rich element containing mRNA in cancer cells.2018
- Author(s)
  Yanagawa-Matsuda A, Mikawa Y, Habiba U, Kitamura T, Yasuda M, Towfik-Alam M, Kitagawa Y, Minowa K, Shindoh M, Higashino F
- Journal Title
  
  Oncol Rep.
  
  Volume: 41(2) Pages: 954-960
- DOI
  10.3892/or.2018.6865
- NAID
  120006709288
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09737, KAKENHI-PROJECT-17F17123
[Journal Article] Involvement of UTR-dependent gene expression in the maintenance of cancer stem cell like phenotypes.2015
- Author(s)
  Yasuda M, Hatanaka T, Shirato H, Nishioka T
- Journal Title
  
  Oncology Letters
  
  Volume: 10 Issue: 5 Pages: 3171-3176
- DOI
  10.3892/ol.2015.3688
- NAID
  120005714778
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K11064
[Journal Article] Activating Transcription Factor 5 Enhances Radioresistance and Malignancy in Cancer Cells2014
- Author(s)
  S. Ishihara, M. Yasuda, A. Ishizu, M. Ishikawa, H. Shirato, H. Haga
- Journal Title
  
  Oncotarget
  
  Volume: 09 Jul Issue: 1 Pages: 1-8
- DOI
  10.1007/s10616-014-9766-4
- NAID
  120005613573
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390285, KAKENHI-PUBLICLY-25127701, KAKENHI-PROJECT-25287106, KAKENHI-PROJECT-26430104
[Journal Article] Cell type-specific reciprocal regulation of HIF1A gene expression is dependent on 5'-and 3'-UTRs2014
- Author(s)
  Yasuda M, Hatanaka T, Shirato H, Nishioka T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 16;447(4) Issue: 4 Pages: 638-643
- DOI
  10.1016/j.bbrc.2014.04.058
- NAID
  120006803963
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390285
[Journal Article] Lung cancer cells that survive ionizing radiation show increased integrin α2β1- and EGFR-dependent invasiveness2013
- Author(s)
  Xue Li, Seiichiro Ishihara, Motoaki Yasuda, Takeshi Nishioka, Takeomi Mizutani, Masayori Ishikawa, Kazushige Kawabata, Hiroki Shirato, Hisashi Haga
- Journal Title
  
  PLoS One
  
  Volume: 8(8) Issue: 8 Pages: 1-12
- DOI
  10.1371/journal.pone.0070905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770167, KAKENHI-PUBLICLY-24106502, KAKENHI-PROJECT-24390285, KAKENHI-PROJECT-25287106
[Journal Article] Irradiation-tolerant lung cancer cells acquire invasive ability dependent on dephosphorylation of the myosin regulatory light chain2013
- Author(s)
  Ishihara S, Yasuda M, Nishioka T, Mizutani T, Kawabata K, Shirato H, Haga H
- Journal Title
  
  FEBS Lett
  
  Volume: 587(6) Issue: 6 Pages: 732-736
- DOI
  10.1016/j.febslet.2013.01.055
- NAID
  120005228631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249065, KAKENHI-PROJECT-23651099, KAKENHI-PROJECT-23770167, KAKENHI-PROJECT-24370069, KAKENHI-PROJECT-24390285
[Journal Article] Radiation-induced cancer cell repopulation : a possible mechanism implied by experiments using transplantable mouse-derived sarcoma cell line.2011
- Author(s)
  Nishioka T, Yasuda M, Takeshima T, Haga H, Miyai Y, Shibata K, Yamazaki R, Shirato H, Teduka M, Date H.
- Journal Title
  
  Cell Struct Funct. 36
  
  Pages: 13-20
- NAID
  40019163767
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390319
[Journal Article] Integrin betal-dependent invasive migration of irradiation-tolerant human lung adenocarcinoma cells in 3D collagen matrix.2010
- Author(s)
  Ishihara S, Haga H, Yasuda M, Mizutani T, Kawabata K, Shirato H, Nishioka T.
- Journal Title
  
  Biochem Biophys Res. 396
  
  Pages: 651-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390319
[Journal Article] Superselective high-dose cisplatin infusion with concomitant radiotherapy in patients with advanced cancer of the nasal cavity and paranasal sinuses : a single institution experience.2009
- Author(s)
  Tsutsumi K, Tsuda M, Yazawa N, Nakamura H, Ishihara S, Haga H, Yasuda M, Yamazaki R, Shirato H, Kawaguchi H, Nishioka T
- Journal Title
  
  Cell Structure and Function 34
  
  Pages: 86-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390319
[Journal Article] The diacylated lipopeptide FSL-1 enhances phagocytosis of bacteria by macrophages through Toll-like receptor 2-mediated signaling pathway2007
- Author(s)
  Mae M, Iyori M, Yasuda M, Shamsul H, Kataoka H, Hasebe A, Kiura K, Totsuka Y, Shibata K
- Journal Title
  
  FEMS Immunology and Medical Microbiology 49
  
  Pages: 398-409
- NAID
  120002451616
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390498
[Journal Article] The diacylated lipopeptide FSL-1 enhances phagocytosis of bacteria by macrophages through Toll-like receptor 2-mediated signaling pathway.2007
- Author(s)
  Mae M, Iyori M, Yasuda M, Shamsul H, Kataoka H, Hasebe A, Kiura K, Totsuka Y, Shibata K.
- Journal Title
  
  FEMS Immunol. Med. Microbiol 49
  
  Pages: 398-409
- NAID
  120002451616
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390498
[Journal Article] Roles of N-linked glycans in the recognition of microbial lipopeptides and lipoproteins by TLR22006
- Author(s)
  Kataoka H., Yasuda M., Iyori M., Kiura K., Narita M., Nakata T., Shibata K.
- Journal Title
  
  Cellular Microbiology 8
  
  Pages: 1199-1207
- NAID
  120000955850
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390498
[Journal Article] CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex2006
- Author(s)
  T.Nakata, M.Yasuda, M.Fujita, H.Kataoka, K.Kiura, H.Sano, K.Shibata
- Journal Title
  
  Cellular Microbiology 8
  
  Pages: 1899-1909
- NAID
  120000955848
- Data Source
  KAKENHI-PROJECT-17390498
[Journal Article] The diacylated lipopeptide FSL-1 induces TLR2-mediated Th2 responses.2006
- Author(s)
  K.Kiura, H.Kataoka, M.Yasuda, N.Inoue, K.Shibata*.
- Journal Title
  
  FEMS Immunol. Med. Microbiol 48
  
  Pages: 44-55
- NAID
  120002451618
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390498
[Journal Article] The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through TLR22006
- Author(s)
  Kiura K., Kataoka H., Nakata T., Into T., Yasuda M., Akira S., Inoue N., Shibata K.
- Journal Title
  
  FEMS Immunology and Medical Microbiology 46
  
  Pages: 78-84
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390498
[Journal Article] CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex.2006
- Author(s)
  T.Nakata, M.Yasuda, M.Fujita, H.Kataoka, K.Kiura, H.Sano, K.Shibata*.
- Journal Title
  
  Cell. Microbiol 8
  
  Pages: 1899-1909
- NAID
  120000955848
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390498
[Journal Article] X-ray irradiation altered chemosensitivity of a p53-null non-small cell lung cancer cell line.2006
- Author(s)
  Tsutsumi K, Yasuda M, Nishioka T
- Journal Title
  
  Cell Struct Funct 31
  
  Pages: 47-52
- NAID
  130004053855
- Data Source
  KAKENHI-PROJECT-18390325
[Journal Article] CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex2006
- Author(s)
  Nakata, M.Yasuda, M.Fujita, H.Kataoka, K.Kiura, H.Sano, K.Shibata^*
- Journal Title
  
  Cellular Microbiology 8
  
  Pages: 1899-1909
- NAID
  120000955848
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390498
[Journal Article] The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through TLR2.2006
- Author(s)
  Kiura K., Kataoka H., Nakata T., Into T., Yasuda M.Akira S., Inoue N., Shibata K.
- Journal Title
  
  FEMS Immunol. Med. Microbiol 46
  
  Pages: 78-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390498
[Journal Article] Reduced Transactivation Activity of P53 and Repressed CDK Inhibitor Observed in Sub-clone That Survived 10Gy Irradiation : Possible Mechanism of Radiation-Induced Cancer Cell Repopulation.2006
- Author(s)
  Nishioka T, Yasuda M, Shirato H
- Journal Title
  
  Int J Radiat Oncol Biol Phys 66(S)
  
  Pages: 586-587
- Data Source
  KAKENHI-PROJECT-18390325
[Journal Article] The diacylated lipopeptide FSL-1 induces TLR2-mediated Th2 responses2006
- Author(s)
  K.Kiura, H.Kataoka, M.Yasuda, N.Inoue, K.Shibata
- Journal Title
  
  FEMS Immunology and Medical Microbiology 48
  
  Pages: 44-55
- NAID
  120002451618
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390498
[Journal Article] Roles of N-linked glycans in the recognition of microbial lipopeptides and lipoproteins by TLR2.2006
- Author(s)
  Kataoka H., Yasuda M., Iyori M., Kiura K., Narita M., Nakata T., Shibata K.
- Journal Title
  
  Cell Microbiol 8
  
  Pages: 1199-1207
- NAID
  120000955850
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390498
[Journal Article] Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappaB activation.2004
- Author(s)
  T Into, K Kiura, M Yasuda, H Kataoka, N Inoue, A Hasebe, K Takeda, S Akira, K Shibata.
- Journal Title
  
  Cell Microbiol 6(2)
  
  Pages: 187-199
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390549
[Journal Article] Stimulation of human Toll-like receptor(TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappaB activation2004
- Author(s)
  T.Into, K.Kiura, M.Yasuda, H.Kataoka, N.Inoue, A.Hasebe, K.Takeda, S.Akira, K.Shibata
- Journal Title
  
  Cellular Microbiology 6(2)
  
  Pages: 187-199
- Data Source
  KAKENHI-PROJECT-15390549
[Journal Article] Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by Toll-like receptors 2 and 6.2004
- Author(s)
  T Okusawa, M Fujita, J Nakamura, T Into, M Yasuda, A Yoshimura, Y Hara, A Hasebe, DT Golenbock, M Morita, Y Kuroki, T Ogawa, K Shibata.
- Journal Title
  
  Infect Immun 72(3)
  
  Pages: 1657-1665
- NAID
  120002451624
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390549
[Journal Article] Involvement of leucine residues at positions 107,112 and 115 in a leucine-rich repeat motif of human Toll-like receptor 2 in the recognition of diacylated lipoproteins and lipopeptides and Staphylococcus aureus peptidoglycans.2003
- Author(s)
  M Fujita, T Into, M Yasuda, T Okusawa, S Hamahira, Y Kuroki, A Eto, T Nisizawa, M Morita, K Shibata.
- Journal Title
  
  J Immunol. 171
  
  Pages: 3675-3683
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390549
[Journal Article] The comprehensive detection system for human papillomavirus.2003
- Author(s)
  Yasuda M
- Journal Title
  
  Seminar of virus infection Vol.5
  
  Pages: 14-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13576026
[Journal Article] 口腔粘膜におけるヒトパピローマウイルス感染とウイルスゲノムの網羅的検出法2003
- Author(s)
  安田元昭
- Journal Title
  
  ウイルス感染症セミナー第5号
  
  Pages: 13-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13576026
[Journal Article] Involvement of leucine residues at positions 107,112 and 115 in a leucine-rich repeat motif of human Toll-like receptor 2 in the recognition of diacylated lipoproteins and liopeptides and Staphylococcus aureus peptidoglycans2003
- Author(s)
  M.Fujita, T.Into, M.Yasuda, T.Okusawa, S.Hamahira, Y.Kuroki, A.Eto, T.Nisizawa, M.Morita, K.Shibata.
- Journal Title
  
  Journal of Immunology 171
  
  Pages: 3675-3683
- Data Source
  KAKENHI-PROJECT-15390549
[Presentation] A novel role for E4 orf4 in the translation of late adenovirus mRNA2018
- Author(s)
  Motoaki Yasuda, Fumihiro Higashino
- Organizer
  ＲＮＡ学会
- Data Source
  KAKENHI-PROJECT-18K09737
[Presentation] HuBによるHuR核外輸送と腫瘍悪性化2016
- Author(s)
  畑中知之・安田元昭
- Organizer
  北大・部局横断シンポジウム
- Place of Presentation
  北海道大学医学部学友会館フラテホール
- Year and Date
  2016-03-07
- Data Source
  KAKENHI-PROJECT-15K11064
[Presentation] アデノウイルスE4orf4による後期遺伝子の新規翻訳活性化機構2016
- Author(s)
  安田元昭
- Organizer
  第６４回日本ウイルス学会学術集会
- Place of Presentation
  札幌コンベンションセンター（札幌）
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-15K11064
[Presentation] RNA結合タンパク質HuBによる口腔扁平上皮がんの分化制御2015
- Author(s)
  畑中知之・安田元昭・三河洋平・東野史裕・進藤正信・鄭　漢忠
- Organizer
  第60回日本口腔外科学会総会・学術大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K11064
[Presentation] アデノウイルスの感染によるP-Bodiesの変化はARE-mRNAを安定化する2014
- Author(s)
  松田彩、東野史裕、黒嶋雄志、安田元昭、北村哲也、進藤正信
- Organizer
  第25回日本臨床口腔病理学会総会・学術大会
- Place of Presentation
  メディアシップ日報ホール（新潟県新潟市）
- Year and Date
  2014-08-27
- Data Source
  KAKENHI-PROJECT-25670840
[Presentation] X-Ray Irradiation Induces Mitophagy and Cancer Metabolic Reprogramming2014
- Author(s)
  T. Nishioka, H. Shirato M. Yasuda
- Organizer
  ASTRO (American Society for Radiation Oncology), 55th Annual meeting
- Place of Presentation
  サンフランシスコ
- Year and Date
  2014-09-15
- Data Source
  KAKENHI-PROJECT-24390285
[Presentation] HIF-1 post transcriptional regulation by means of 5'UTR.2012
- Author(s)
  Takeshi Nishioka,Motoaki YasudaHiroki Shirato
- Organizer
  日本癌学会総会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-22592081
[Presentation] HIF-1alpha post transcriptional mRNA regulation under normoxia2012
- Author(s)
  Takeshi Nishioka, Motoaki Yasuda , Hiroki Shirato
- Organizer
  the significance of UTRs
- Place of Presentation
  国際がんセミナー北海道大学医学部フラテ会館
- Data Source
  KAKENHI-PROJECT-22592081
[Presentation] DNAがんウイルスは自然免疫応答を抑制する2007
- Author(s)
  安田元昭
- Organizer
  第49回歯科基礎医学会学術大会・総会
- Place of Presentation
  札幌市北大学術交流会館
- Year and Date
  2007-08-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591994
[Presentation] HIF-1alpha Post Transcriptional mRNA Regulation Under Normoxia
- Author(s)
  Takeshi Nishioka, Hiroki Shirato, Motoaki Yasuda
- Organizer
  アメリカ放射線腫瘍学会
- Place of Presentation
  アトランタ　Georgia World Congress Center
- Data Source
  KAKENHI-PROJECT-24390285

1. HIGASHINO Fumihiro (50301891)

# of Collaborated Projects: 23 results

# of Collaborated Products: 8 results
2. SHINDO Masanobu (20162802)

# of Collaborated Projects: 21 results

# of Collaborated Products: 1 results
3. YOKOYAMA Atsuro (20210627)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
4. KOBAYASH Masandu (80241321)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. TOTSUKA Yasunori (00109456)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
6. KAWASAKI Takao (90002229)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. YAMAMOTO Satoru (10344524)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. NISHIOKA Takeshi (80271659)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
9. HAGA Hisahi (00292045)

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10. HOMMA Akiniro (30312359)

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13. SHIBATA Ken-ichiro (50145265)

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# of Collaborated Products: 16 results
14. 北村哲也 (00451451)

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15. TUTSMI Kaori (80344505)

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16. SATO Yoshinori (30374995)

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17. KUROKI Yoshio (70161784)

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24. YUDASAKA Masako (70159226)

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25. AMIZUKA Norio (30242431)

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26. SHIRATO Hiroki (20187537)

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27. MORIUCHI Tetsuya (20174394)

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28. YOSHIDA Koichi (60117653)

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29. ONO Mitsunobu (50281829)

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30. HIROSHI Fukkuda (30001019)

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31. ICHIZO Kobayashi (70170305)

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32. CHIHIRO Sugiura (30312375)

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33. TEI Kanchu (80180066)

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34. OHIRO Yoichi (40301915)

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35. NAKADA Kunihiro (00301010)

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36. HORIUCHI Rumi (10374274)

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37. 工藤真幸 (10164500)

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38. 藤永恵 (10045338)

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39. 武島嗣英 (10360950)

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# of Collaborated Products: 0 results
40. 澤田幸治 (80111128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 松田彩 (60514312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
42. NAKASU Masanori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. YAMAMOTO Akiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. HANAWA Takao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 水谷武臣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 西尾禎治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 水田正弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yasuda Motoaki 安田 元昭

YASUDA Motoaki 安田 元昭

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難治性口腔がんに有効な腫瘍溶解ウイルスの開発Principal Investigator

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Oncolytic virus targeting oral cancer stem cellsPrincipal Investigator

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Analysis of comprehensive gene regulation systems in oral cancer stem cellsPrincipal Investigator

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Cross-talk between innate-immunological responses and oral oncogenesis.Principal Investigator

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Yasuda Motoaki 安田元昭

YASUDA Motoaki 安田元昭