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TAKAYAMA Yoshinaga  高山 吉永

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… Alternative Names

高山 吉永  タカヤマ ヨシナガ

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Researcher Number 90245407
Other IDs
Affiliation (Current) 2025: 北里大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2016: 北里大学, 医学部, 講師
1994 – 2004: 北里大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Bacteriology (including Mycology) / General medical chemistry
Except Principal Investigator
Pediatrics / Pediatrics / Immunology
Keywords
Principal Investigator
補体 / セリンプロテアーゼ / RaRF / モノクロナル抗体 / ヌードマウス / 発毛誘導 / クローニング / PCR / MBL / コレクチン … More / 多型解析 / 遺伝子診断 / 遺伝子構造 / 分子生物学 / cDNA / ゲノム / MBP / 補体活性化 … More
Except Principal Investigator
CRTH2 genes / IL-10 / Fas ligand / Fas / functional IgE / Ra-reactive factor (RaRF) / CRISPR/Cas9 / モザイク / LOH / 髄芽腫 / PTCH1 / 遺伝子編集 / iPS細胞 / CRISPR/Cas9システム / 母斑基底細胞癌症候群 / DF-specific anergy of T cells / roxithromycin / apoptosis / mite-sensitive bronchiral asthma / IgE産生の抑制 / アポトーシス誘導Tリンパ球のクローン細胞 / 疾患感受性遺伝子 / アポトーシス誘導サイトカイン / ダニ抗原特異IgE産生B細胞株 / 小児気管支喘息 / CD47 / ダニ / 気管支喘息 / Th2細胞 / B細胞 / IgE / CRTH2 / Df-specific anergy of T cells / Roxithromycin / Apoptosis / mite-sensitive bronchial asthma / Hemimethylated DNA binding / Gel-shift Assay / DNA binding specificity / ETS family transcription factors / Developmental stage specific expression / T cell receptor / DNA結合 / T細胞レセプターγ鎖 / 転写因子 / ETSファミリー / ヘミメチル化DNAの結合 / ゲルシフト・アッセイ法 / DNA結合特異性 / Etsファミリー転写因子 / 発生段階特異的発現 / T細胞レセプター / gene diagnosis / mannan binding lectin (MBL) / gene analysis / complement activation / recurrent infectious / infirmative constitution / complement / Maunose binding protein (MBP) / Mannan binding protein (MBP) / 遺伝子診断 / Ra-reactive factor(RaRF) / Mannan binding lectin(MBL) / 遺伝子解析 / 補体活性化 / 易感染性体質 / 虚弱体質 / 補体 Less
  • Research Projects

    (8 results)
  • Research Products

    (10 results)
  • Co-Researchers

    (11 People)
  •  Basic studies toward CRISPR/Cas9-mediated cell therapy

    • Principal Investigator
      Miyashita Toshiyuki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kitasato University
  •  モノクロナル抗体が強制的に誘導するヌードマウス発毛メカニズムの解明Principal Investigator

    • Principal Investigator
      高山 吉永
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Kitasato University
  •  Analysis of new genes involved in allergic diseases

    • Principal Investigator
      NOMA Takeshi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kitasato University
  •  自然免疫に関わる新規ヒト血清コレクチンの探索Principal Investigator

    • Principal Investigator
      高山 吉永
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Kitasato University
  •  Study on the relationship of T-cell receptor y-chain rearrangement and ETSfamily transcription factors

    • Principal Investigator
      TAKAGAKI Yohtaroh
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      KITASATO UNIVERSITY
  •  補体活性化血清殺菌因子-RaRF-と易感染性体質との遺伝学的研究(遺伝子診断技術への応用)Principal Investigator

    • Principal Investigator
      高山 吉永
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Kitasato University
  •  Development of a rapid diagnosis system for the recurrent infectious constitutions.

    • Principal Investigator
      MATUURA Nobuo
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pediatrics
    • Research Institution
      Kitasato University
  •  補体活性化血清殺菌因子-RaRF-と易感染性体質との遺伝学的研究Principal Investigator

    • Principal Investigator
      高山 吉永
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Kitasato University

All 2017 2016 2015 Other

All Journal Article Presentation

  • [Journal Article] Somatic mosaicism containing double mutations in PTCH1 revealed by generation of induced pluripotent stem cells from nevoid basal cell carcinoma syndrome.2017

    • Author(s)
      Ikemoto, Y., Takayama, Y., Fujii, K., Masuda, M., Kato, C., Hatsuse, H., Fujitani, K., Nagao, K., Kameyama, K., Ikehara, H., Toyoda, M., Umezawa, A. and Miyashita, T.
    • Journal Title

      Journal of Medical Genetics

      Volume: - Issue: 8 Pages: 579-584

    • DOI

      10.1136/jmedgenet-2016-104490

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461530, KAKENHI-PROJECT-15K19041, KAKENHI-PROJECT-15K09729, KAKENHI-PROJECT-16K09960, KAKENHI-PROJECT-17K10061
  • [Journal Article] Nevoid basal cell carcinoma syndrome caused by splicing mutations in the PTCH1 gene.2017

    • Author(s)
      Kato, C., Fujii, K., Arai, Y., Hatsuse, H., Nagao, K., Takayama, Y., Kameyama, K., Fujii, K., and Miyashita, T.
    • Journal Title

      Familial Cancer

      Volume: 16 Issue: 1 Pages: 131-138

    • DOI

      10.1007/s10689-016-9924-2

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461530, KAKENHI-PROJECT-16K09960
  • [Presentation] Gorlin症候群患者由来iPS細胞を用いた髄芽腫の作製2016

    • Author(s)
      池本 優、豊田 雅士、那須 道世、初瀬 洋美、長尾 和右、高山 吉永、亀山 孝三、梅澤 明弘、宮下 俊之
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26461530
  • [Presentation] Entire PTCH1 deletions detected in 9 families with nevoid basal cell carcinoma syndrome2016

    • Author(s)
      高山吉永、長尾一右、藤井克則、宮下俊之
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26461530
  • [Presentation] Establishment of the cell lines with a large genomic deletion by CRISPR/Cas9 system.2015

    • Author(s)
      長尾和右、高山吉永、宮下俊之
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26461530
  • [Presentation] CRISPR/Cas9システムを用いた2点同時切断による目的ゲノム領域除去細胞株の作製2015

    • Author(s)
      加藤千勢、長尾和右、初瀬洋美、高山吉永、亀山孝三、宮下俊之
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26461530
  • [Presentation] CRISPR/Cas9システムによる欠失導入効率の検討

    • Author(s)
      加藤千勢 高山吉永 亀山孝三 初瀬洋美 長尾和右 宮下俊之
    • Organizer
      第27回北里大学バイオサイエンスフォーラム
    • Place of Presentation
      北里大学(神奈川県相模原市)
    • Year and Date
      2014-08-21 – 2014-08-22
    • Data Source
      KAKENHI-PROJECT-26461530
  • [Presentation] CRISPR/Cas9システムを用いたSNPジェノタイプ転換の試み

    • Author(s)
      高山吉永 初瀬洋美 中島早耶 鈴木香織 加藤千勢 長尾和右 亀山孝三 宮下俊之
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-26461530
  • [Presentation] CRISPR/Cas9システムを用いた広域欠損ゲノムを有する細胞株の作製

    • Author(s)
      長尾和右 加藤千勢 初瀬洋美 高山吉永 亀山孝三 宮下俊之
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-26461530
  • [Presentation] CRISPR/Cas9システムを用いたソニックヘッジホッグシグナル伝達系構成遺伝子ノックアウト細胞株の作製

    • Author(s)
      長尾和右 高山吉永 宮下俊之
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26461530
  • 1.  MATUURA Nobuo (50002332)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  TAKAGAKI Yotaro (50281324)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  KAMEYAMA Kouzou (40214556)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 4.  TAKADA Fumio (90206764)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  OGUCHI Kouki (30133292)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  KOBAYASHI Kunihiko (60091451)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  NAKAJIMA Youichi (70050599)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SHINOHARA Nobukarta (20125933)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  NOMA Takeshi (60208387)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  Miyashita Toshiyuki (60174182)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 11.  NAGAO Kazuaki (60392487)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results

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