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ADACHI Takehiko  足立 健彦

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… Alternative Names

足立 健彦  アダチ タケヒコ

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Researcher Number 90252428
Other IDs
External Links
Affiliation (Current) 2025: 公益財団法人田附興風会, 医学研究所北野病院 病態生理・薬理研究部, 研究員
Affiliation (based on the past Project Information) *help 2012 – 2020: 公益財団法人田附興風会, 医学研究所 第9研究部, 部長
2014: 公益財団法人田附興風会, 医学研究所第9研究部, 部長
2011: 公益財団法人田附興風会, 医学研究所・第9研究部, 部長
2011: 公益財団法人田附興風会, 医学研究所第9研究部, 部長
2010: 財団法人田附興風会, 医学研究所第9研究部, 部長 … More
2009: Tazuke Kofukai Medical Research Institute, 医学研究所 第9研究部, 部長
2008: Tazuke Kofukai Medical Research Institute, 医学研究所第9研究部, 部長
2008: Tazuke Kofukai Medical Research Institute, 第9研究部, 部長
2007: Tazuke Kofukai Medical Research Institute, 医学研究所 第3研究部, 研究主幹
2006: (財)田附興風会, 第三研究部, 研究主幹
2005: THE TAZUKE KOFUKAI, Medical Research Institute, 3^<rd> Division, Chief Researcher, 医学研究所第3研究部, 研究主幹
2003 – 2004: 財団法人田附興風会, 医学研究所・第3研究部, 研究主幹
2003: 財団法人田附興風会, 第三研究部, 研究主幹
2002 – 2003: 田附興風会, 第三研究部, 研究主幹
1997 – 1999: Kyoto Univ.Faculty of Medicine, Lecturer, 医学研究科, 講師
1995 – 1996: 京都大学, 医学研究科, 助手
1994: 京都大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies / Basic Section 55050:Anesthesiology-related / Anesthesiology
Except Principal Investigator
Anesthesiology/Resuscitation studies
Keywords
Principal Investigator
低酸素誘導性因子1 / HIF-1 / 肺障害 / 低酸素誘導性因子 / carrageenan / Wind Up / 遺伝子発現 / 水チャネル / タバコ / 肺胞上皮 … More / ストレス / 笑気 / 一酸化窒素 / CD39 / CD73 / 細胞間バリア機能 / interferonβ-1a / 急性呼吸窮迫症候群 / 急性肺傷害 / TXNIP / thioredoxin / 急性肺障害 / 敗血症 / 酸素環境 / gene expression / stress / perioperative period / hypoxia-inducible factor / 亜硝酸製剤 / 低酸素遺伝子応答 / オピオイド / 血管拡張薬 / 炎症 / シグナル伝達 / 局所麻酔薬 / 静脈麻酔薬 / 低酸素誘導性遺伝子応答 / 発現制御 / 生体分子 / 周術期 / Analgesia / Descending Inhibitory System / Dorsal Horn / Nitrous Oxide / Xenon / 下行性抑制系 / 脊髄後角 / 鎮痛 / 下行性抑制係 / 脊髄後角ニューロン / キセノン / Wide Dynamic Range Neuron / Spinal Cord / carageenan / 広作動域ニューロン / 脊髄 / 低酸素 / 肺胞炎症 / 肺水腫 / タイトジャンクション / 無気肺 / 低酸素誘導性遺伝子 / 周術期管理学 / 麻酔 / real time PCR / 培養細胞 / 時計遺伝子 / 概日リズム / 遺伝子 / 日内変動 / 体内時計 / 急性耐性 / ナロキソン / 体性交感神経反射電位 / 最小肺胞内濃度 / ハロセン … More
Except Principal Investigator
Anesthetics / Aggregation / Platelet / Liver Transplantation / 麻酔薬 / 凝集能 / 血小板 / 生体肝移植術 / wide dynamic range neuron / multi-unit activity / electroencephalogram / somatosensory evoked potentials / nitrous oxide / xenon / 笑気 / 中脳網様体多要素電気活動 / 広作動域ニューロン / 脊髄後角 / 体性感覚誘発電位 / 中脳網様体多要素神経活動 / 脳波 / 亜酸化窒素 / キセノン Less
  • Research Projects

    (13 results)
  • Research Products

    (23 results)
  • Co-Researchers

    (10 People)
  •  The crosstalk between hypoxic reaction system and IFNbeta-1a signal at the control of vascular endothelial barrier functionPrincipal Investigator

    • Principal Investigator
      Adachi Takehiko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      The Tazuke Kofukai
  •  The role of cellular redox system in inflammatory disorders of acute lung injuryPrincipal Investigator

    • Principal Investigator
      ADACHI Takehiko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      The Tazuke Kofukai
  •  The impact of HIF-1 activation on respiratory epithelium during hypoxic insults.Principal Investigator

    • Principal Investigator
      ADACHI Takehiko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      The Tazuke Kofukai
  •  Cell biological analysis of the effect of hypoxia-induced gene expressions on progression of pulmonary alveolar inflammationPrincipal Investigator

    • Principal Investigator
      ADACHI Takehiko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      公益財団法人田附興風会
      Tazuke Kofukai Medical Research Institute
  •  Cellular and molecular biological analysis of hypoxia-inducible genetic responses in lung epithelial cellsPrincipal Investigator

    • Principal Investigator
      ADACHI Takehiko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Tazuke Kofukai Medical Research Institute
  •  体内時計に麻酔あるいは全身性ストレスが与える影響の検討Principal Investigator

    • Principal Investigator
      足立 健彦
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Tazuke Kofukai Medical Research Institute
  •  The effect of perioperatively used drugs on the HIF-1 activation and its downstream gene expressions.Principal Investigator

    • Principal Investigator
      ADACHI Takehiko
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      THE TAZUKE KOFUKAI
  •  Platelet aggregation changes during liver transplantation surgery

    • Principal Investigator
      HIRAKATA Hideo
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      KYOTO UNIVERSITY
  •  Electrophysiological study on the antinociceptive effect of xenon.Principal Investigator

    • Principal Investigator
      ADACHI Takehiko
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      KYOTO UNIVERSITY
  •  The electrophysiological studies in the action of xenon on the central nervous system

    • Principal Investigator
      MURAKAWA Masahiro
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Fukushima Medical College
      Kyoto University
  •  The effect of inhalation anesthetic on wind up phenomenon of spinal dorsal horn neuronsPrincipal Investigator

    • Principal Investigator
      ADACHI Takehiko
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      KYOTO UNIVERSITY
  •  体性交感神経A-及びC-反射電位に及ぼす笑気の影響に関する研究Principal Investigator

    • Principal Investigator
      足立 健彦
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kyoto University
  •  一酸化窒素合成酵素阻害薬によるハロセン最小肺胞内濃度の低下の機序に関する研究Principal Investigator

    • Principal Investigator
      足立 健彦
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kyoto University

All 2020 2018 2017 2015 2013 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

  • [Journal Article] Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner2018

    • Author(s)
      Sumi Chisato、Okamoto Akihisa、Tanaka Hiromasa、Nishi Kenichiro、Kusunoki Munenori、Shoji Tomohiro、Uba Takeo、Matsuo Yoshiyuki、Adachi Takehiko、Hayashi Jun-Ichi、Takenaga Keizo、Hirota Kiichi
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 2 Pages: e0192796-e0192796

    • DOI

      10.1371/journal.pone.0192796

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10594, KAKENHI-PROJECT-16K10974, KAKENHI-PROJECT-16K10975, KAKENHI-PROJECT-15K10551, KAKENHI-PROJECT-16K15682, KAKENHI-PROJECT-18K08877, KAKENHI-PROJECT-18K16501
  • [Journal Article] Suppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity2018

    • Author(s)
      Sumi Chisato、Okamoto Akihisa、Tanaka Hiromasa、Kusunoki Munenori、Shoji Tomohiro、Uba Takeo、Adachi Takehiko、Iwai Teppei、Nishi Kenichiro、Harada Hiroshi、Bono Hidemasa、Matsuo Yoshiyuki、Hirota Kiichi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 8987-8987

    • DOI

      10.1038/s41598-018-27220-8

    • NAID

      120006539570

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08874, KAKENHI-PROJECT-18K08877, KAKENHI-PROJECT-18K16501, KAKENHI-PROJECT-16K10974, KAKENHI-PROJECT-16K10975
  • [Journal Article] Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1.2015

    • Author(s)
      Suzuki K, Sato Y, Kai S, Nishi K, Adachi T, Matsuo Y, Hirota K.
    • Journal Title

      PeerJ.

      Volume: 3 Pages: 1498-1498

    • DOI

      10.7717/peerj.1498

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10551, KAKENHI-PROJECT-15K20063, KAKENHI-PROJECT-26670693, KAKENHI-PROJECT-26860697
  • [Journal Article] General Anesthetics Inhibit LPS-Induced IL-1beta Expression in Glial Cells.2013

    • Author(s)
      Tanaka T, Kai S, Matsuyama T, Adachi T, Fukuda K, Hirota K.
    • Journal Title

      PLoS ONE.

      Volume: 8 Issue: 12 Pages: 82930-82930

    • DOI

      10.1371/journal.pone.0082930

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592322, KAKENHI-PROJECT-24592336, KAKENHI-PROJECT-24659695, KAKENHI-PROJECT-25462432
  • [Journal Article] Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions.2013

    • Author(s)
      Suzuki K, Nishi K, Takabuchi S, Kai S, Matsuyama T, Kurosawa S, Adachi T, Maruyama T, Fukuda K, Hirota K.
    • Journal Title

      PeerJ.

      Volume: 1 Pages: 220-220

    • DOI

      10.7717/peerj.220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592322, KAKENHI-PROJECT-24592336, KAKENHI-PROJECT-24659695, KAKENHI-PROJECT-25462395, KAKENHI-PROJECT-25462457
  • [Journal Article] General anesthetics inhibit erythropoietin induction under hypoxic conditions in the mouse brain.2011

    • Author(s)
      田中具治、甲斐慎一、小山智弘、大条紘樹、足立健彦、福田和彦、広田喜一
    • Journal Title

      PLoS One

      Volume: 6 Issue: 12 Pages: 29378-29378

    • DOI

      10.1371/journal.pone.0029378

    • NAID

      120003726125

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249081, KAKENHI-PROJECT-21591992, KAKENHI-PROJECT-22390298, KAKENHI-PROJECT-22659282, KAKENHI-PROJECT-22659283
  • [Journal Article] Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a μ-opioid receptor-dependent manner.2011

    • Author(s)
      大条紘樹、甲斐慎一、田中具治、若松拓彦、岸本俊、鈴木堅悟、原田浩、高淵聡史、足立健彦、福田和彦、広田喜一
    • Journal Title

      Eur J Pharmacol

      Volume: 667 Issue: 1-3 Pages: 144-152

    • DOI

      10.1016/j.ejphar.2011.06.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249081, KAKENHI-PROJECT-21591992, KAKENHI-PROJECT-22390298, KAKENHI-PROJECT-22659282, KAKENHI-PROJECT-22659283, KAKENHI-PROJECT-22791428, KAKENHI-PROJECT-22791429
  • [Journal Article] Persisting mild hypothermia suppresses hypoxia-inducible factor-1alpha protein synthesis and hypoxia-inducible factor-1-mediated gene expression.2010

    • Author(s)
      田中具治、若松拓彦、大条紘樹、小田聖子、甲斐慎一、足立健彦、木坂(近藤)科江、福田和彦、広田喜一
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 298 Issue: 3 Pages: 661-671

    • DOI

      10.1152/ajpregu.00732.2009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249081, KAKENHI-PROJECT-21591992, KAKENHI-PROJECT-22390298, KAKENHI-PROJECT-22659283
  • [Journal Article] The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular cells2009

    • Author(s)
      Oda S, Oda T, Takabuchi S, Nishi K, Wakamatsu T, Tanaka T, Adachi T, Fukuda K, Nohara R, Hirota K
    • Journal Title

      Eur J Pharmacol 606

      Pages: 130-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Journal Article] The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular cells2009

    • Author(s)
      Oda, S., Oda, T., Takabuchi, S., Nishi, K., Wakamatsu, T., Tanaka, T., Adachi, T., Fukuda, K., Nohara, R., and Hirota, K.
    • Journal Title

      Eur J Pharmacol

      Volume: 606 Issue: 1-3 Pages: 130-136

    • DOI

      10.1016/j.ejphar.2009.01.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591992
  • [Journal Article] n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems2008

    • Author(s)
      Kimura M, Takabuchi S, Tanaka T, Murata M, Nishi K, Oda S, Oda T, Kanai M, Fukuda K, Kizaka-Kondoh S, Adachi T, Takabayashi A, Semenza GL, Hirota K
    • Journal Title

      Biochem J 411

      Pages: 97-105

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Journal Article] LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner2008

    • Author(s)
      Nishi K, Oda T, Takabuchi S, Oda S, Fukuda K, Adachi T, Semenza GL, Shingu K, Hirota K
    • Journal Title

      Antioxid Redox Signal 10

      Pages: 983-96

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Journal Article] Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner2008

    • Author(s)
      Oda S, Oda T, Nishi K, Takabuchi S, Wakamatsu T, Tanaka T, Adachi T, Fukuda K, Semenza GL, Hirota K
    • Journal Title

      PLoS ONE 3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Journal Article] Exhaled carbon monoxide levels change in relation to inspiredoxygen fraction during general anesthesia2007

    • Author(s)
      Takehiko Adachi,
    • Journal Title

      Anesthesia and Analgesia 105

      Pages: 696-699

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Journal Article] Exhaled carbon monoxide levels change in relation to inspired oxygen fraction during general anesthesia2007

    • Author(s)
      Adachi T, Hirota K, Hara T, Sasaki Y, Hara Y
    • Journal Title

      Anesth Analg 105

      Pages: 696-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Journal Article] Activation of hypoxia-inducible factor 1 during macrophage differentiation2006

    • Author(s)
      Oda, T., Adachi, T et al.
    • Journal Title

      Am J Physiol Cell Physiol, (In press)

    • Data Source
      KAKENHI-PROJECT-15390481
  • [Journal Article] Opioid receptor stimulation does not affect cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 1 in cultured cell lines2005

    • Author(s)
      Takabuchi, S., Adachi, T.et al.
    • Journal Title

      J Anesth 19

      Pages: 263-265

    • NAID

      10016650659

    • Data Source
      KAKENHI-PROJECT-15390481
  • [Journal Article] The effect of local anesthetics on the cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 1.2005

    • Author(s)
      Nishi, K., Adachi, T.et al.
    • Journal Title

      J.Anesth 19

      Pages: 54-59

    • NAID

      10014428952

    • Data Source
      KAKENHI-PROJECT-15390481
  • [Presentation] インターフェロンβ1-aはCD73の発現を制御しLPSによる肺血管透過性亢進を改善する2020

    • Author(s)
      松川志乃、甲斐慎一、松尾禎之、足立健彦、福田和彦、広田喜一
    • Organizer
      第47回日本集中治療医学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K08877
  • [Presentation] HIF-1-Mediated Suppression of Mitochondria Electron Transport Chain Function Confers _Resistance to Lidocaine-induced Cell Death2017

    • Author(s)
      SHINICHI KAI, Kiichi Hirota, Chisato Sumi, Akihisa Okamoto, Kenichiro Nishi, Munenori Kusunoki, Yoshiyuki Matsuo, Takehiko Adachi
    • Organizer
      American Society of Anesthesiology 2017 annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10551
  • [Presentation] Isoflurane selectively inhibits the activation of hypoxia-inducible factor 2 and the induction of erythropoietin under hypoxic conditions in mouse brain2011

    • Author(s)
      Kiichi Hirota, Tomoharu Tanaka, Shinichi Kai, Tomohiro Koyama, Hiroki Daijo, Kengo Suzuki, Takehiko Adachi, Kazuhiko Fukuda
    • Organizer
      2011 Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      2011-10-16
    • Data Source
      KAKENHI-PROJECT-21591992
  • [Presentation] The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular endothelial and smooth muscle cells2008

    • Author(s)
      Takehiko Adachi, Seiko Oda, Satoshi Takabuchi , Kenichiro Nishi, Kiichi Hirota
    • Organizer
      2008Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      Orland
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Presentation] The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular endothelial and smooth muscle cells2008

    • Author(s)
      足立健彦
    • Organizer
      2008アメリカ麻酔科学会
    • Place of Presentation
      オーランド
    • Year and Date
      2008-10-20
    • Data Source
      KAKENHI-PROJECT-19591827
  • 1.  HIROTA Kiichi (00283606)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 2.  MIYAZAKI Yoshiya (10324625)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  MURAKAWA Masahiro (90182112)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  NAKAO Shinichi (10207714)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  HIRAKATA Hideo (70271509)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  SASAKI Yukiko (70301744)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  廣田 喜一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 14 results
  • 8.  福田 和彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 9.  竹永 啓三
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  岩井 鉄平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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