Ishii Yuji 石井祐次

… Alternative Names

ISHII Yuji 石井祐次

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Researcher Number	90253468
Other IDs
External Links
Affiliation (Current)	2022: 九州大学, 薬学研究院, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2022: 九州大学, 薬学研究院, 准教授 2013 – 2015: 九州大学, 薬学研究科(研究院), 准教授 2011: 九州大学, 大学院・薬学研究院, 准教授 2007 – 2011: Kyushu University, 薬学研究院, 准教授 2008 – 2009: Kyushu University, 大学院・薬学研究院, 准教授 … More 2004 – 2006: Kyushu University, Graduate School of Pharmaceutical Sciences, Associate Professor, 薬学研究院, 助教授 2003: 九州大学, 大学院・薬学研究院, 助教授 2001 – 2002: 筑波大学, 社会医学系, 講師 2000: 九州大学, 大学院・薬学研究院, 助手 1999: 九州大学, 大学院・薬学研究科, 助手 1995 – 1998: 九州大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Anesthesiology/Resuscitation studies / Hygiene / Environmental impact assessment / Environmental and hygienic pharmacy / Medium-sized Section 63:Environmental analyses and evaluation and related fields Except Principal Investigator Environmental pharmacy / Environmental pharmacy / Biological pharmacy / Anesthesiology/Resuscitation studies / 環境影響評価(含放射線生物学)
Keywords	Principal Investigator 薬物代謝 / UGT / モルヒネ / グルクロン酸抱合 / P450 / タンパク質間相互作用 / UDP-グルクロン酸転移酵素 / シトクロムP450 / 活性代謝物 / 肝臓 … More / グルクロン酸転移酵素 / polychlorinated biphenyl / dioxin / carbonic anhydrase / suppression / liver / CYP / 次世代影響 / 環境化学物質 / 薬学 / ヒト / グルクロン酸包合 / クローニング / モルモット / 脳 / phosphatase / gene regulation / apoptosis / Carbonic anhydrase / cDNA cloning / muscle / Ah-receptor / PCB / alcohol dehydrogenase / 薬物代謝学 / 活性化 / 個体差 / アデニンヌクレオチド / 機能的相互作用 / アデニン / 内因性低分子化合物 / タンパク質問相互作用 / 架橋 / 免疫沈降 / drug metabolism / adenine / protein-protein interaction / endogenous small compound / morphine / cross-linking / ダイオキシン / 発育障害 / 環境汚染物質 / 有害化学物質 / 環境 / フェノバルビタール / マウス / Ugt … More Except Principal Investigator UDP-glucuronosyltransferase / モルヒネ / morphine / 慢性中毒 / 介入研究 / cytochrome P450 / ダイオキシン / 胎児 / 性腺ステロイドホルモン / 脳下垂体ホルモン / 後世代影響 / ステロイドホルモン / 性未成熟 / インプリンティング / 下垂体 / 性腺刺激ホルモン / 視床下部 / メタボローム解析 / 胎児期特異性 / 性差 / 性行動障害 / 内分泌攪乱 / 性ステロイド合成酵素 / 亜鉛 / PCB / ラット / トリオースリン酸 / チロシンホスファターゼ / 炭酸脱水酵素 / アルコール脱水素酵素 / アルドラーゼ / ホメオスタシス / 亜鉛フィンガー / 転写調節因子 / cytosol / aldolase / rat / alcohol dehydrogenase / triose phosphate / tyrosine phosphatase / carbonic anhydrase / polychlorinated biphenyl / 鎮痛薬 / グルクロナイド / 活性代謝物 / UDP-グルクロン酸転移酵素 / cDNA / オリゴマー / モルモット / グルクロン酸転移酵素 / クローニング / 遺伝子発現 / ヒト / 肝臓 / グルクロン酸抱合 / 薬物代謝 / guinea pig / oligomer / protein interaction / active metabolite / morphine-6-glucuronide / morphine-3-glucuronide / 砒素の地下水汚染 / 角化症 / 色素沈着・脱失 / 砒素 / 慢性砒素中毒 / 井戸水中砒素 / 一酸化窒素 / 井地水中砒素 / ヒ素 / サイクリックGMP / 機能的相互作用 / Cytochrome P450 / UDP-Glucuronosyltransferase / RNAi / 免疫沈降 / 共発現 / Kinetics / functional protein-protein interaction Less

内外環境の破綻による次世代影響評価：発達障害と性未成熟の機構の検証と予防Principal Investigator
- Principal Investigator
  
  石井祐次
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Kyushu University
内外環境の攪乱による次世代影響評価：発達障害と性成熟障害のメカニズムの検証と予防Principal Investigator
- Principal Investigator
  
  石井祐次
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Environmental impact assessment
- Research Institution
  Kyushu University
Novel hypothesis for phenobarbital induction of drug metabolizing enzyme: Investigation of a model and a mechanismPrincipal Investigator
- Principal Investigator
  
  ISHII YUJI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Kyushu University
Basic study for appropriate use of clinical medicine: functional interaction of drug metabolizing enzymes and its significance in vivoPrincipal Investigator
- Principal Investigator
  
  Ishii Yuji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
Bas i s stud i es on the appropr i ate usage of c l i n i ca I med i c i ne : i so form specificity of the functional interaction between drug metabolizing enzymes and the individual differencesPrincipal Investigator
- Principal Investigator
  
  ISHII Yuji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
Dioxin-induced imprinting of sexual immaturity and its mechanism
- Principal Investigator
  
  YAMADA Hideyuki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Kyushu University
Basic Studies on the appropriate usage of clinical narcotics : the individual differences in the formation of morphine active metabolite which is not dependent on the genetic polymorphismPrincipal Investigator
- Principal Investigator
  
  ISHII Yuji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
Basic approach for good prescribing: Post-translational modulation of activities of drug-metabolizing enzymesPrincipal Investigator
- Principal Investigator
  
  ISHII Yuji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  KYUSHU UNIVERCITY
Evidence for functional interaction between phase I and phase II drug metabolizing enzymes
- Principal Investigator
  
  YAMADA Hideyuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Kyushu University
AhレセプターとC/EBPのクロストークを介した肝特異的遺伝子発現の抑制Principal Investigator
- Principal Investigator
  
  石井祐次
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hygiene
- Research Institution
  University of Tsukuba
内モンゴルの慢性砒素汚染地域での介入研究
- Principal Investigator
  
  下條信弘 (下条信弘)
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  University of Tsukuba
中国の慢性砒素汚染地域での介入研究:生体内NO産生変動と中毒症状軽減との関係
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Tsukuba
環境ホルモンコプラナーPCBによる細胞質チロシンホスファターゼの抑制メカニズムPrincipal Investigator
- Principal Investigator
  
  石井祐次
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hygiene
- Research Institution
  Kyushu University
モルヒネ活性代謝物生成に関わるグルクロン酸転移酵素の臓器分布についてPrincipal Investigator
- Principal Investigator
  
  石井祐次
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyushu University
Studies on Narcotic UDP-Glucuronosyltransferases for effective and safty use in clinical application
- Principal Investigator
  
  OGURI Kazuta
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  KYUSHU UNIVERSITY
モルヒネ活性代謝物生成に関わるヒト肝グルクロン酸転移酵素のクローニングと発現Principal Investigator
- Principal Investigator
  
  石井祐次
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyushu University
REGULATION OF ZINC PROTEINS AND CELLULAR ZINC HOMEOSTASIS
- Principal Investigator
  
  OGURI Kazuta
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  FACULTY OF PHARMACEUTICAL SCIENCES,KYUSHU UNIVERSITY

[Book] Cytochrome P450-Dependent Change in UDP-Glucuronosyltransferase Function and Its Reverse Regulation. Chapter 18, in “The 50th Anniversary of Cytochrome P450 research”. Ed Yamazaki H.2014
- Author(s)
  Yuji Ishii, Yuu Miyauchi, Hideyuki Yamada
- Publisher
  Springer Japan, Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-25293039
[Book] Chapter 3) Cytochrome P450-depedent change in UDP-glucuronosyltransferase function and its reverse regulation, Part 5 "Drug Metabolism", in "Fifty Years of Cytochrome P450 Research"2014
- Author(s)
  Ishii Y, Miyauchi Y, Yamada H
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-25293039
[Journal Article] Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.2017
- Author(s)
  Kurita A, Miyauchi Y, Ikushiro S, Mackenzie PI, Yamada H, Ishii Y.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 361 Pages: 199-208
- DOI
  10.1124/jpet.117.240382
- NAID
  120006305614
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26292072, KAKENHI-PROJECT-16K15148
[Journal Article] Suppression of Cytochrome P450 3A4 Function by UDP-Glucuronosyltransferase 2B7 through a Protein-Protein Interaction: Cooperative Roles of the Cytosolic Carboxyl-Terminal Domain and the Luminal Anchoring Region2015
- Author(s)
  Miyauchi Y, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H, Ishii Y
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 88 Pages: 800-812
- DOI
  10.1124/mol.115.098582
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460195, KAKENHI-PROJECT-25293039
[Journal Article] Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants.2014
- Author(s)
  Ishii Y, Koba H, Kinoshita K, Oizaki T, Iwamoto Y, Takeda S, Miyauchi Y, Nishimura Y, Egoshi N, Taura F, Morimoto S, Ikushiro S, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 42 Pages: 229-238
- DOI
  10.1124/dmd.113.054833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293039, KAKENHI-PROJECT-25460195
[Journal Article] Modulation of UDP-glucuronosyltransferase by protein-protein association2010
- Author(s)
  Ishii Y, 他2名
- Journal Title
  
  Drug Metabolism Review 42
  
  Pages: 140-153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590164
[Journal Article] Activation of morphine glucuronidation by fatty acyl-CoAs and its plasticity : a comparative study in humans and rodents including chimeric micecarrying human liver.2010
- Author(s)
  Nurrochmad A, Ishii Y, 他xx名
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 25 Pages: 62-73
- NAID
  10027582853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590164
[Journal Article] Modulationof UDPglucuronosyltransferase Activity by Endogenous Compounds2010
- Author(s)
  Ishii Y, Nurrochmad A, Yamada H.
- Journal Title
  
  Drug Metab. Pharmacokinet
  
  Volume: 25 Pages: 134-148
- Data Source
  KAKENHI-PROJECT-21590164
[Journal Article] Modulation of UDP-glucuronosyltransferase activity by endogenous compounds2010
- Author(s)
  Ishii Y, Nurrochmad A, Yamada H
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 25 Pages: 134-148
- NAID
  10027582269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590164
[Journal Article] Modulation of UDPglucuronosyltransferase by ProteinProtein Association2010
- Author(s)
  Ishii Y, Takeda S, Yamada H.
- Journal Title
  
  Drug Metab. Rev
  
  Volume: 42 Pages: 140-153
- Data Source
  KAKENHI-PROJECT-21590164
[Journal Article] Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity : A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver2010
- Author(s)
  Nurrochmad A, Ishii Y, 他8名
- Journal Title
  
  Drug Metabolism and Pharmacokinetics (In press)
- NAID
  10027582853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590164
[Journal Article] Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity : A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver2010
- Author(s)
  Nurrochmad A, Ishii Y, Nakanoh H, Inoue T, Horie T, Sugihara K, Ohta S, Taketomi A, Maehara Y, Yamada H.
- Journal Title
  
  Drug Metab. Pharmacokinet.
  
  Volume: 25 Pages: 262-273
- NAID
  10027582853
- Data Source
  KAKENHI-PROJECT-21590164
[Journal Article] Modulation of UDP-glucuronosyltransferase activity by endogenous compounds2010
- Author(s)
  Ishii Y, 他2名
- Journal Title
  
  Drug Metabolism and Pharmacokinetics (In press)
- NAID
  10027582269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590164
[Journal Article] Maternal exposure to dioxin disrupts gonadotropin production in fetal rats and imprints defects in sexual behavior.2009
- Author(s)
  1 Takeda, T., Matsumoto, Y., Koga, T., Mutoh, J., Nishimura, Y., Shimazoe, T., Ishii, Y., Ishida, T., Yamada, H.
- Journal Title
  
  J. Pharmacol. Exp. Ther. 929
  
  Pages: 1091-1099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390034
[Journal Article] Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7 : evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interaction.2009
- Author(s)
  S. Takeda, Y, Ishii, 他
- Journal Title
  
  Molecular Pharmacology 75
  
  Pages: 956-964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590147
[Journal Article] Interaction of Cytochrome P450 3A4 and UDPGlucuronosyltransferase 2B7 : Evidence for Protein-Protein Association and Possible Involvement of CYP3A4 J-Helix in the Interaction2009
- Author(s)
  Takeda S, Ishii Y, Iwanaga M, Nurrochmad A, Ito Y, Mackenzie PI, Nagata K, Yamazoe Y, Oguri K, Yamada H
- Journal Title
  
  Mol Pharmacol.(corresponding author) 75(4)
  
  Pages: 956-964
- Data Source
  KAKENHI-PROJECT-19590147
[Journal Article] Protein-protein interactions between rat hepatic cytochromes P450(P450s) and UDP-glucuronosyltransferases (UGTs):evidence for the functionally active UGT in P450-UGT complex2007
- Author(s)
  Ishii, et. al.
- Journal Title
  
  Drug Metab.Pharmacokinet 22
  
  Pages: 367-376
- NAID
  10019806746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590147
[Journal Article] Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase:structure-effect relationships and evidence for an allosteric mechanism2007
- Author(s)
  Nishimura, et. al.(Corresponding author:Ishii Y)
- Journal Title
  
  Biochim Biophys.Acta 1770
  
  Pages: 1557-1566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590147
[Journal Article] Proteinprotein interactions between rat hepatic cytochromes P450 (P450s) and UDPglucuronosyltransferases (UGTs) : Evidence for the functionally active UGT in P450-UGT complex2007
- Author(s)
  Ishii Y, Iwanaga M., Nishimura Y, Takeda S, Ikushiro, S., Nagata K, Yamazoe Y, Mackenzie PI, and Yamada, H.
- Journal Title
  
  Drug Metab. Pharmacokinet. 22(5)
  
  Pages: 367-376
- NAID
  10019806746
- Data Source
  KAKENHI-PROJECT-19590147
[Journal Article] Inhibitory effects of adenine nucleotides and related substances on UDPglucuronosyltransferase : structure-effect relationships and evidence for an allosteric mechanism2007
- Author(s)
  Nishimura Y, Maeda S, Ikushiro, S., Mackenzie PI, Ishii Y, and Yamada, H.
- Journal Title
  
  Biochim. Biophys. Acta(corresponding author) 1770(11)
  
  Pages: 1557-1566
- Data Source
  KAKENHI-PROJECT-19590147
[Journal Article] Inhibition of UDP-glucuronosyltransferase 2B7-catalyzed morphine glucuronidation by ketoconazole : Dual mechanisms involving a novel non-competitive mode.2006
- Author(s)
  Takeda S, Kitajima Y.Ishii Y.Nishimura Y, et al.
- Journal Title
  
  Drug Metab.Dispos. 34
  
  Pages: 1277-1282
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590128
[Journal Article] Inhibition of UDP-glucuronosyltransferase 2B7-catalyzed morphine glucuronidation by ketoconazole : Dual mechanisms involving a novel non-competitive mode.2006
- Author(s)
  Takeda S, Kitajima, Y, Ishii Y, Nishimura Y, 外4名
- Journal Title
  
  Drug Metab. Dispos. 34
  
  Pages: 1277-1282
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590128
[Journal Article] Fatty acyl-CoA as an endogenous activator of UDP-glucuronosyltransferases.2006
- Author(s)
  Okamura, K, Ishii.Y., 他3名(corresponding author)
- Journal Title
  
  Biochem. Biophys. Res. Commun. 345
- Data Source
  KAKENHI-PROJECT-17590128
[Journal Article] Fatty acyl-CoA as an endogenous activator of UDP-glucuronosyltransferases.2006
- Author(s)
  Okamura K, Ishii Y (corresponding author) et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 345
  
  Pages: 1649-1656
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590128
[Journal Article] Inhibition of UDP-glucuronosyltransferase 2B7-catalyzed morphine glucuronidation by ketoconazole : Dual mechanisms involving a novel non-competitive mode.2006
- Author(s)
  Takeda S, Kitajima, Y, Ishii Y, Nishimura Y, 他4名
- Journal Title
  
  Drug Metab. Dispos. 34
- Data Source
  KAKENHI-PROJECT-17590128
[Journal Article] Fatty acyl-CoA as an endogenous activator of UDP-glucuronosyltransferases.2006
- Author(s)
  Okamura, K, Ishii.Y., 外3名(corresponding author)
- Journal Title
  
  Biochem. Biophys. Res. Commun. 345
  
  Pages: 1649-1656
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590128
[Journal Article] Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro : differential effects of CYP1A2,CYP2C9 and CYP3A4.2005
- Author(s)
  Takeda S, Ishii Y, et al.
- Journal Title
  
  Biol.Pharm, Bull. 28
  
  Pages: 2026-2027
- NAID
  110003666390
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590128
[Journal Article] Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro : differential effects of CYP1A2, CYP2C9 and CYP3A4.2005
- Author(s)
  Takeda S, Ishii Y, 他5名
- Journal Title
  
  Biological and Pharmaceutical Bulletin 28(10)
  
  Pages: 2026-2027
- NAID
  110003666390
- Data Source
  KAKENHI-PROJECT-17590128
[Journal Article] Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450 : Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Morphine by CYP3A4.2005
- Author(s)
  Takeda S., Ishii Y., Iwanaga M., Mackenzie P.I., Nagata K., Yamazoe Y., Oguri K., Yamada H.
- Journal Title
  
  Mol Pharmacol 67
  
  Pages: 665-672
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370765
[Journal Article] Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro : differential effects of CYP1A2, CYP2C9 and CYP3A4.2005
- Author(s)
  Takeda S, Ishii Y, 他5名
- Journal Title
  
  Biol. Pharm. Bull. 28(10)
  
  Pages: 2026-2027
- NAID
  110003666390
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590128
[Journal Article] Cytochrome P450 1A1 (CYP1A1) inhibitor α-naphthoflavone interferes with UDP-glucuronosyltransferase (UGT) activity in intact but not in permeabilized hepatic microsomes from 3-methylcholanthrene-treated rats : possible involvement of UGT-P450 interactions.2004
- Author(s)
  Taura K, Naito E, Ishii Y, Mori M, Oguri K, Yamada H
- Journal Title
  
  Biol Pharm Bull 27
  
  Pages: 56-60
- NAID
  110003608618
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370765
[Presentation] Comprehensive characterization of mouse hepatic UDPglucuronosyltransferases: Major participation of Ugt2b34 in acetaminophen glucuronidation2018
- Author(s)
  Ryohei Yamashita, Ayumi Kurita, Yuu Miyauchi, Shinichi Ikushiro, Peter I Mackenzie, Yoshitaka Tanaka, Yuji Ishii
- Organizer
  2018 International Meeting on 22nd MDO (The International symposium on microsomes and Drug Oxidations) and 33rd JSSX (The Japanese Society of Study for Xenobiotics)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15148
[Presentation] Comprehensive characterization of mouse hepatic UDP-glucuronosyltransferases: major participation of Ugt1a1 in SN-38 glucuronidation2017
- Author(s)
  Kohei Yamashita, Ayumi Kurita, Yuu Miyauchi, Shin’ichi Ikushiro, Peter I. Mackenzie, Yuji Ishii
- Organizer
  日本薬物動態学会第32年会
- Data Source
  KAKENHI-PROJECT-16K15148
[Presentation] UDP-グルクロン酸転移酵素 1A7の208番目のアミノ酸の役割：シトクロムP450 3A4 との機能的相互作用2016
- Author(s)
  江越菜月, 木下亨佑, 古葉弘樹、生城真一, 永田　清, 山添　康, Peter I. Mackenzie, 山田英之, 石井祐次
- Organizer
  日本薬学会第 136 年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] Functional interaction of UDP-glucuronosyltransferases and cytochrome P450 3A4: the domain of UGT involved in the interaction2016
- Author(s)
  Yuji Ishii
- Organizer
  21st International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  米国カリフォルニア州デービス
- Year and Date
  2016-10-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] マウス肝の全UDP-グルクロン酸転移酵素分子種の包括的特性評価2016
- Author(s)
  栗田歩実, 宮内優, Mackenzie, P.I., 山田英之, 石井祐次
- Organizer
  第33回日本薬学会九州支部大会
- Place of Presentation
  鹿児島市
- Year and Date
  2016-12-03
- Data Source
  KAKENHI-PROJECT-16K15148
[Presentation] Mutual Modulation of UDP-Glucuronosyltransferases and Cytochrome P450 3A4: Domains Involved in the Functional and Physical Interactions2016
- Author(s)
  Yujii Ishii
- Organizer
  11th International ISSX meeting
- Place of Presentation
  韓国プサン
- Year and Date
  2016-06-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] Protein-protein interaction of cytochrome P450 (CYP) 3A4 and UDP-glucuronosyltransferase (UGT) 1A7: the involvement of 208th residue of UGT1A7 in the functional interaction and evidence for the physical interaction in living cells by fluorescent resonance energy transfer (FRET) analysis。2016
- Author(s)
  Egoshi N, Kinoshita K, Koba H, Takeda T, Ikushiro S, Nagata K, Yamazoe Y, Peter I Mackenzie, Yamada H, Ishii Y
- Organizer
  55th Annual Meeting of the Society of Toxicology
- Place of Presentation
  米国ルイジアナ州ニューオリンズ
- Year and Date
  2016-03-14
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] Comprehensive characterization of mouse hepatic UDP-glucuronosyltransferases belonging to 2B subfamily: major participation of Ugt2b36 in morphine and diclofenac glucuronidation.2016
- Author(s)
  Ayumi Kurita, Yuu Miyauchi, Peter I. Mackenzie, Hideyuki Yamada, Yuji Ishii
- Organizer
  日本薬物動態学会第31年会
- Place of Presentation
  松本市
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K15148
[Presentation] Protein-protein interaction of cytochrome P450 (CYP) 3A4 and UDP-glucuronosyltransferase (UGT) 1A7 in living cells: functional interaction and fluorescent resonance energy transfer (FRET) analysis.2015
- Author(s)
  Natsuki Egoshi，Kousuke Kinoshita, Hiroki Koba, Shin-ichi Ikushiro，Kiyoshi Nagata，Yasushi Yamazoe，Peter I. Mackenzie，Hideyuki Yamada，Yuji Ishii.
- Organizer
  30th Annual Meeting of the Japanese Society for the Study of Xenobiotics.
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] Comprehensive characterization of mouse hepatic UDP-glucuronosyltransferases belonging to the 2b subfamily involved in morphine and estradiol glucuronidation.2015
- Author(s)
  Ayumi Kurita, Yuu Miyauchi, Peter I. Mackenzie, Hideyuki Yamada, and Yuji Ishii.
- Organizer
  30th Annual Meeting of the Japanese Society for the Study of Xenobiotics.
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] Domains of UDP-glucuronosyltransferase serve in the functional interaction with cytochrome P450 3A4.2015
- Author(s)
  Yuji Ishii, Yuu Miyauchi, Natsuki Egoshi, Hideyuki Yamada
- Organizer
  19th International Conference of Cytochrome P450
- Place of Presentation
  東京
- Year and Date
  2015-06-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] シトクロムP450 3A4 とUDP-グルクロン酸転移酵素1A7の相互作用 : 機能的タンパク質間相互作用および物理的連携の解析.2015
- Author(s)
  江越菜月, 木下亨佑, 古葉弘樹、生城真一, 永田　清, 山添　康, Peter I. Mackenzie, 山田英之, 石井祐次
- Organizer
  第32回日本薬学会九州支部大会
- Place of Presentation
  宮崎県延岡市
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] UDP-グルクロン酸転移酵素( UGT)1A7 の W208R 変異がシトクロム P450 3A4 による UGT1A7 機能の調節に及ぼす影響2014
- Author(s)
  江越菜月、石井祐次、木下亨佑、古葉弘樹、生城真一、永田清、山添康、Peter I. Mackenzie、山田英之
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市　熊本大学
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] UDP-Glucuronosyltransfera se 2B7 の小胞体局在における内腔側ドメインの重要性2014
- Author(s)
  木村天、宮内　優、廣田有子、田中嘉孝、マッケンジー, ピーター、山田英之、石井祐次
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市　熊本大学
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] UDP-グルクロン酸転移酵素 (UGT) との相互作用によるシトクロム P450 3A4 機能の変化 : UGT2B7 内腔側ドメインと cytosolic tail の協調による CYP3A4 の抑制2014
- Author(s)
  宮内優、石井祐次、永田清、山添康、マッケンジー・ピーター、山田英之
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市　熊本大学
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] Suppression of cytochrome P450 3A4 activity by UDP-glucuronosyltransferase 2B7: Crucial role of the length of UGT2B7 cytosolic tail in the suppression2013
- Author(s)
  Yuu Miyauchi, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Hideyuki Yamada, Yuji Ishii
- Organizer
  28th Annual meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  東京　タワーホール船堀
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] CYTOCHROME P450 3A4 RESTORES THE CATALYTIC PROPERTY OF UDP-GLUCURONOSYLTRANSFERASE 1A1*6, ONE OF THE ALLELIC VARIANTS WHICH ARE CONCERNED FOR CAUSING GILBERT SYNDROME2013
- Author(s)
  Kousuke Kinoshita, Toshiya Oizaki, Yuki Iwamoto, Yuu Miyauchi, Shin-ichi Ikushiro, Yasushi Yamazoe, Kiyoshi Nagata, Peter I. Mackenzie, Hideyuki Yamada, and Yuji Ishii
- Organizer
  28th Annual meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  東京　タワーホール船堀
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] UDP-グルクロン酸転移酵素との相互作用によるシトクロム P450 3A4 活性の抑制2013
- Author(s)
  宮内　優、永田　清、山添　康、Peter I. Mackenzie、山田　英之、石井祐次
- Organizer
  P450, UGT, SULT研究会
- Place of Presentation
  宮崎市シーガイヤコテージヒムカ
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] INCONSEQUENTIAL ROLE OF C-TERMINAL DOUBLE LYSINE MOTIF IN THE RETENTION OF UDP-GLUCURONOSYLTRANSFERASE 2B7 ON THE ENDOPLASMIC RETICULUM2013
- Author(s)
  Sora Kimura, Yuu Miyauchi, Peter I. Mackenzie, Hideyuki Yamada, Yuji Ishii
- Organizer
  28th Annual meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  東京　タワーホール船堀
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] UDP-Glucuronosyltransferase 2B3 (UGT2B3)への糖鎖の導入がcytochrome P450 3A依存的なUGT調節作用に及ぼす影響.2013
- Author(s)
  中村達郎, 宮内　優, 武田知起, 山添　康, 永田　清, マッケンジーピーター, 山田英之, 石井祐次
- Organizer
  第30回日本薬学会九州支部大会
- Place of Presentation
  長崎県佐世保市　長崎国際大学
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] モノテルペノイドアルコール類によるモルヒネUDP-グルクロン酸転移酵素の阻害2012
- Author(s)
  飯田直子、石井祐次、宮内優、マッケンジー・ピーター、山田英之
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] モノテルペノイドアルコール類によるモルヒネUDP一グルクロン酸転移酵素の阻害2012
- Author(s)
  飯田直子、石井祐次、宮内優、マッケンジー・ピーター、山田英之
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] 異種薬物代謝酵素間相互作用による代謝制御:UDP-glucuronosyltransferase1A9および2B7によるcytochrome P450 3A4活性の調節2011
- Author(s)
  宮内優、石井祐次、追崎俊也、永田清、山添康、Peter I.Mackenzie、山田英之
- Organizer
  第28回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] 生体内化合物によるUDP一グルクロン酸転移酵素活性の制御2011
- Author(s)
  安貴愛、石井祐次、西村嘉雄、山田英之
- Organizer
  第28回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] 麻薬の代謝とその変動要因2011
- Author(s)
  石井祐次,山田英之
- Organizer
  日本法中毒学会第30年会
- Place of Presentation
  長崎
- Year and Date
  2011-06-10
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Toshiya Oizaki, Yasushi Yamazoe, Kiyoshi Nagata, Peter I. Mackenzie, HideyukiYamada, Hetero-Oligomerization of UDP-Glucuronosyltransferases and CytochroP4so450 3A4 : Analysis by Fluorescence Resonance Energy Transfer(FRET) and Modulation of CYPsA43A4 acti2011
- Author(s)
  Yuu Miyauchi, Yuji Ishii
- Organizer
  26th Annual Meeting oSociety for the Study of Xenobiotics
- Place of Presentation
  Hiroshima
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Yuu Miyauchi, Hideyuki Yamada, Protein猶rotein Interaction of Cytochrome P450 and UDP宥lucuronosyltransferase2011
- Author(s)
  Yuji Ishii
- Organizer
  Alteration of P450 activity by UGT. 4th Asian猶acific ISSX meeting
- Place of Presentation
  Tainan, Taiwan
- Year and Date
  2011-04-24
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Alteration in UDP-Glucuronosyltransferase Function by Endogenous Substances with Low Molecular Weight2011
- Author(s)
  Yuji Ishii, Arief Nurrochmad, Yoshio Nishimura, Kie An, Naoko Iida, Hideyuki Yamada
- Organizer
  26th Annual meeting of Japanese Society for the study of Xenobiotics
- Place of Presentation
  広島(招待講演)
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Inhibitory Effect of Adenine-Related Compounds on UDP-Glucuronosyltransferase Activity in Human Liver Microsomes2011
- Author(s)
  Kie An, Yoshio Nishimura, Yuji Ishii, Hideyuki Yamada
- Organizer
  26th Annual meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  広島
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] and Hideyuki Yamada, Inhibitory Effect of AdenineRelated Compounds on UDPGlucuronosyltransferase Activity in Human Liver Microsomes2011
- Author(s)
  Kie An, Yoshio Nishimura, Yuji Ishii
- Organizer
  26th Annual Meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  Hiroshima
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Effect of Cytochrome P450 3A4 on the Function of UDP-Glucuronosyltransferase 1A3 : Alteration of Affinity toward UDP-Glucuronic acid2011
- Author(s)
  Kousuke Kinoshita, Yuji Ishii, Yuu Miyauchi, Toshiya Oizaki, Shin-ichi Ikushiro, Yasushi Yamazoe, Kiyoshi Nagata, Peter I.Mackenzie, Hideyuki Yamada
- Organizer
  26th Annual meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  広島
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Yuu Miyauchi, Toshiya Oizaki, Shin-ichi Ikushiro, Yasushi Yamazoe, Kiyoshi Nagata, Peter I. Mackenzie and Hideyuki Yamada, Effect of Cytochrome P4so 3A4 on the Functionof UDP-Glucuronosyltransferase 1A3 : Alteration of Affinity toward UDP-Glucuronic Acid2011
- Author(s)
  Kousuke Kinoshita, Yuji Ishii
- Organizer
  26th Annual Meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  Hiroshima
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Protein-Protein Interaction of Cytochrome P450 and UDP-Glucuronosyltransferase : Alteration of P450 activity by UGT2011
- Author(s)
  Yuji Ishii, Yuu Miyauchi, Hideyuki Yamada
- Organizer
  4th Asian-Pacific ISSX meeting 2011
- Place of Presentation
  Tainan, Taiwan(招待講演)
- Year and Date
  2011-04-24
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] 生体内化合物によるUDP-グルクロン酸転移酵素活性の制御2011
- Author(s)
  安貴愛、石井祐次、西村嘉雄、山田英之
- Organizer
  第28回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] 麻薬の代謝とその変動要因2011
- Author(s)
  石井祐次, 山田英之
- Organizer
  日本法中毒学会第30年会
- Place of Presentation
  長崎(招待講演)
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Hetero-Oligomerization of UDP-Glucuronosyltransferases and Cytochrome P450 3A4 : Analysis by Fluorescence Resonance Energy Transfer (FRET) and Modulation of CYP3A4 activity by UGTs2011
- Author(s)
  Yuu Miyauchi, Yuji Ishii, Toshiya Oizaki, Yasushi Yamazoe, Kiyoshi Nagata, Peter I.Mackenzie, Hideyuki Yamada
- Organizer
  26th Annual meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  広島
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] アデニン関連化合物によるUDP一グルクロン酸転移酵素活性の阻害作用:界面活性剤およびpore-forming peptideアラメチシン処理での比較2011
- Author(s)
  安貴愛、西村嘉雄、石井祐次、山田英之
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Ariel Nurrochmad, Yoshio Nishimura, Kie An, Naoko Iida, Hideyuki Yamada, Alteration in UDPGlucuronosyltransferase Function by Endogenous Substances with Low Molecular Weight2011
- Author(s)
  Yuji Ishii
- Organizer
  26th Annual Meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  Hiroshima
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Toshiya Oizaki, Arielf Nurrochmad, Shin-ichi Ikushiro, Yasushi Yamazoe, Kiyoshi Nagata, Peter I. Mackenzie and Hideyuki Yamada, Comparison ofCatalytic Properties BetweenHuman UDPGlucuronosyltransferase 1A7* 3, an Allelic Variant, and its Wild-type 1A7* 12010
- Author(s)
  Hiroki Koba, Yuji Ishii
- Organizer
  25th Annual Meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  Ohmiya, Saitama
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] UDP一グルクロン酸転移酵素1A7の遺伝的多型と触媒活性:シトクロムP4450 3A4共発現による影響2010
- Author(s)
  古葉弘樹、石井祐次、追崎俊也、竹田修三、生城真一、永田清、山添康、Peter I. Mackenzie、山田英之
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Comparison of catalytic properties between human UDP-glucuronosyltransferase 1A7^*3, an allelic variant and its wild-type 1A7^*12010
- Author(s)
  Hiroki Koba, Yuji Ishii, Toshiya Oizaki, Arief Nurrochmad, Shin-ichi Ikushiro, Yasushi Yamazoe, Kiyoshi Nagata, Peter I.Mackenzie, Hideyuki Yamada
- Organizer
  25th Amnual meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  大宮市
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] UDP-グルクロン酸転移酵素1A7の遺伝的多型と触媒活性:シトクロムP450 3A4 共発現による影響2010
- Author(s)
  古葉弘樹、石井祐次、追崎俊也、竹田修三、生城真一、永田清、山添康、Peter I.Mackenzie、山田英之
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎市
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Modulation of cytochrome P450 activity by UDP-glucuronosyltransferase : major human UGT isoforms, UGT2B7, 1A1, 1A6 and 1A9 enhance CYP3A4-catalyzed oxidation.2010
- Author(s)
  Yuu Miyauchi, Yuji Ishii, Hideyuki Yamada, Japanese Society for the Study of Xenobiotics
- Organizer
  25th Annual meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  大宮市
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Protein-rotein Association of Cytochrome P4so and UDP宥lucuronosyltransferase : Its Relevance to Enzyme Function2010
- Author(s)
  Yuji Ishii
- Organizer
  25th Annual meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  Ohmiya, Saitama
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] UGT-CYP protein interactions : role of conjugating enzymes in modulating oxidative enzyme activity2010
- Author(s)
  Yuji Ishii
- Organizer
  ASPET 2010 Annual Meeting at EB2010
- Place of Presentation
  米国カリフォルニア州アナハイム(招待講演)
- Year and Date
  2010-04-28
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] UGT-CYP Protein Interactions : Role of Conjugating Enzymes in Modulating Oxidative Enzyme Activity. American Society for Pharmacology and Experimental2010
- Author(s)
  Yuji Ishii
- Organizer
  Therapeutics 2010 Annual Meeting at Experimental Biology
- Place of Presentation
  Anaheim, California, U. S. A.
- Year and Date
  2010-04-28
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Protein-protein association of cytochrome P450 and UDP-glucuronosyltransferase : Its relevance to enzyme function2010
- Author(s)
  Yuji Ishii
- Organizer
  25th Annual meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  大宮市(招待講演)
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Arielf Nurrochmad, Akinobu Taketomi, Yoshihiko Maehara and Hideyuki Yamada, Activation of Morphine Glucuronidation by Fatty Acyl-CoA : Enhanced Incorporation of UDPGlucuronic Acid into the Endoplasmic Reticulum2009
- Author(s)
  Yuji Ishii
- Organizer
  24th Annual Meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  Kyoto
- Year and Date
  2009-11-26
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] モルヒネUDP-グルクロン酸転移酵素の脂肪酸アシルCoA による活性化 : 活性化作用に肝臓の凍結融解が及ぼす影響2009
- Author(s)
  Arief Nurrochamd, 石井祐次, 中能ひとみ, 武冨紹信, 前原喜彦, 山田英之
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] 脂肪酸アシルCoAによるモルヒネグルクロン酸抱合の活性化2009
- Author(s)
  石井祐次
- Organizer
  UGT研究会2009
- Place of Presentation
  静岡
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Cytochrome P450 3A4 enhances UDP-glucuronosyltransferase 1A9-catalyzed glucuronidation of SN-38, an active metabolite of irinotecan2009
- Author(s)
  Ishii Y, Iwamoto Y., 他10名
- Organizer
  The 3rd Asian-Pacific Regional ISSX Meeting
- Place of Presentation
  タイ王国バンコク市
- Year and Date
  2009-05-10
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] ダイオキシンによるラット胎児脳下垂体luteinizing hormone合成系の障害:培養脳下垂体を用いた機構解析.2009
- Author(s)
  武田知起, 石井祐次, 石田卓巳, 山田英之
- Organizer
  日本薬学会第129年会
- Data Source
  KAKENHI-PROJECT-19390034
[Presentation] ダイオキシンによる胎児・性ホルモン合成失調の分子機構.2009
- Author(s)
  山田英之, 武田知起, 古賀貴之, 石井祐次, 石田卓巳
- Organizer
  第2回博多シンポジウム:内・外環境と生物応答
- Data Source
  KAKENHI-PROJECT-19390034
[Presentation] A reduction by TCDD in the expression of gonadotropin subunits: its perinatal age-specificity and the mechanism.2009
- Author(s)
  Takeda, T., Fujii, M., Ishii, Y., Ishida, T., Yamada, H.
- Organizer
  HORIBA/CDBIM Symposium: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-19390034
[Presentation] ACTIVATION OF MORPHINE GLUCURONIDATION BY FATTY ACYL-COA : ENHANCED INCORPORATION OF UDP-GLUCURONIC ACID I NTO THE ENDOPLASMIC RETICULUM2009
- Author(s)
  Ishii Y, Nurrochmad, A, 他3名
- Organizer
  24th Annual meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  京都市
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] ット脳下垂体luteinizing hormoneの刺激合成に対するダイオキシンの影響とその胎児特異性.2009
- Author(s)
  武田知起, 藤井美彩紀, 石井祐次, 石田卓巳, 山田英之
- Organizer
  フォーラム2009:衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-19390034
[Presentation] Yuki Iwamoto, Toshiya Oizaki, Arielf Nurrochmad, Yoshio Nishimura, Shin' ichi Ikushiro, Futoshi Taura, Satoshi Morimoto, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Hideyuki Yamada. CytochromeP4so0 3A4 Enhances2009
- Author(s)
  Yuji Ishii
- Organizer
  UDP-lucuronosyltransferase 1A9-Catalyzed Glucuronidation of SN-s88, an Active Metabolite of Irinotecan. Abstract of papers,# 150, The 3rd Asian-Pacific Regional ISSX Meeting
- Place of Presentation
  Bangkok, Thailand, Drug Metab
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Arielf Nurrochmad,山田英之,脂肪酸および脂肪酸CoAがモルヒネグルクロン酸抱合活性に及ぼす影響2009
- Author(s)
  石井祐次
- Organizer
  日本法中毒学会第28年会
- Place of Presentation
  金沢
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] UDP-グルクロン酸転移酵素1A1, 1A6 および1A9 機能にシトクロムP450 3A4 同時発現が及ぼす影響(28P-am068)2009
- Author(s)
  石井祐次, 岩本有樹, 追崎俊也, AriefNurrochamd, 西村嘉雄, 生城真一, 田浦太志, 森元聡, 永田清, 山添康, PeterI. Mackenzie, 山田英之
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] 脂肪酸および脂肪酸CoAがモルヒネグルクロン酸抱合活性に及ぼす影響2009
- Author(s)
  石井祐次, Arief Nurrochmad, 山田英之
- Organizer
  日本法中毒学会第28年会
- Place of Presentation
  金沢市
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Alteration of UDP宥lucuronosyltransferase Activity by CytochromeP4so0 3A42009
- Author(s)
  Yuji Ishii
- Organizer
  Environmental Stimuli and Biological Responses
- Place of Presentation
  Fukuoka
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-21590164
[Presentation] Decrease in the microsomal concentration of inhibitory adenine nucleotides is one possible mechanism of the 'Latency' of UDPglucuronosyltransferase2008
- Author(s)
  Yuji Ishii, Yoshio Nishimura, Hideyuki Yamada
- Organizer
  23^<rd> Annual meeting of Japanese Society for the Study of Xenobiotics(Vol. 23)
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] Activation of morphine UDP-glucuronosyltransferases by fatty acyl-CoAs in human and rat2008
- Author(s)
  Arief Nurrochmad, Yuji Ishii, Hitomi Nakanoh, Akinobu Taketomi, Yoshihiko Maehara, Hideyuki Yamada
- Organizer
  23^<rd> Annual meeting of Japanese Society for the Study of Xenobiotics(Vol. 23)
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] Fatty Acyl-CoAs Activate Morphine UDPGlucuronosyltransferases2008
- Author(s)
  Arief Nurrochmad, Yuji Ishii, Hitomi Nakanoh, Akinobu Taketomi, Yoshihiko Maehara and Hideyuki Yamada
- Organizer
  17^<th> International Symposium on Microsomesand Drug Oxidations
- Place of Presentation
  Saratoga, NY
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] ダイオキシンによる胎児特異的な性ホルモン合成障害の機構:成獣への脳室内投与による検討.2008
- Author(s)
  松本悠揮, 武田知起, 古賀貴之, 石井祐次, 石田卓巳, 山田英之
- Organizer
  フォーラム2008:衛生薬学・環境トキシコロジー
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19390034
[Presentation] Cytochrome P450 3A4 enhances UDPglucuronosyltransferase 1A-catalyzed glucuronidation of 3-hydroxybenzo[a]pyrene : One possible determinant of individual susceptibility to cancer risk from exposure to benzo[a]pyrene2008
- Author(s)
  Yuji Ishii, Toshiya Oizaki, Shuso Takeda, Yoshio Nishimura, Shin'ichi Ikushiro, Futoshi Taura, Satoshi Morimoto, Akinobu Taketomi, Yoshihiko Maehara, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Hideyuki Yamada
- Organizer
  12^<th>UDPGlucuronosyltransferase and glucuronidation workshop
- Place of Presentation
  Quebec,Canada
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] UDP-グルクロン酸転移酵素の活性調節因子としてのアデニンヌクレオチド : 小胞体内腔濃度とその変動2008
- Author(s)
  石井祐次, 西村嘉雄, 前田真吾, 上里祥代, 山田英之
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] シトクロムP450 3A4 とUDP-グルクロン酸転移酵素1A サブファミリーとの機能的相互作用2008
- Author(s)
  追崎俊也, 石井祐次, 竹田修三, 西村嘉雄, 田浦太志, 森元聡, 生城真一, Peter I.Mackenzie, 永田清, 山添康, 山田英之
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] ダイオキシン曝露による雌雄特異的性行動異常:胎仔期の黄体形成ホルモン障害を起点とする機構と性差.2008
- Author(s)
  武田知起, 武藤純平, 竹藤順子, 西村嘉雄, 古賀貴之, 松本悠揮, 石井佑次, 石田卓巳, 山田英之
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19390034
[Presentation] 内因性低分子化合物によるUDP-グルクロン酸転移酵素活性の調節2008
- Author(s)
  石井祐次
- Organizer
  平成20年P450勉強会-UGT研究会(合同開催)
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] Cytochrome P450 3A4 enhances UDP-glucuronosyltransferase 1A-catalyzed glucuronidation of 3-hydroxybenzo[a]pyrene : One possible determinant of individual susceptibility to cancer risk from exposure to benzo[a]pyrene.2008
- Author(s)
  Y, Ishii, 他
- Organizer
  12^<th> UDP-Glucuronosyltransferase and glucur onidation workshop
- Place of Presentation
  Quebec, Canada
- Year and Date
  2008-07-26
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] シトクロムP450 3A4 とUDP-グルクロン酸転移酵素の機能的相互作用 : UGT 分子種特異性2008
- Author(s)
  岩本有樹, 追崎俊也, Arief Nurrochamd, 竹田修三, 西村嘉雄, 生城真一, 田浦太志, 森元聡, 永田清, 山添康, Peter I.Mackenzie, 石井祐次, 山田英之
- Organizer
  第25日本薬学会九州支部大会
- Place of Presentation
  延岡
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] 肝小胞体内腔のアデニンヌクレオチドによるUDP-グルクロン酸転移酵素活性の調節の可能性(J.Health Sci. 53, s-113 (2007))2007
- Author(s)
  西村嘉雄, 前田真吾, 上里祥代, 生城真一, Peter I. Mackenzie, 石井祐次, 山田英之
- Organizer
  フォーラム2007 : 衛生薬学・環境トキシコロジー
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] Interaction of Cytochrome P450 3A4 and UDP-Glucuronosyltransferase 2B7:Posible Involvement of a Region Located in the J-Helix of CYP3A4 in the Interaction2007
- Author(s)
  Ishii, et. al.
- Organizer
  International ISSX
- Place of Presentation
  Sendai, Japan
- Year and Date
  2007-10-12
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] グルクロン酸抱合反応の内因性調節因子に関する研究 : 肝小胞体内腔のアデニンヌクレオチドによる抑制とその機構2007
- Author(s)
  西村嘉雄, 前田真吾, 上里祥代, 生城真一, Peter I. Mackenzie, 石井祐次, 山田英之
- Organizer
  第24日本薬学会九州支部大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] ダイオキシンによるラット胎仔性ホルモン生合成系の障害と雌雄特異的性行動異常について.2007
- Author(s)
  武田知起, 武藤純平, 竹藤順子, 西村嘉雄, 古賀貴之, 松本悠揮, 石井祐次, 石田卓巳, 山田英之
- Organizer
  フォーラム2007:衛生薬学・環境トキシコロジー
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19390034
[Presentation] TCDD母体曝露によるラット胎仔性ホルモン生合成への影響:LHを介する機構.2007
- Author(s)
  武田知起, 武藤純平, 竹藤順子, 石井祐次, 石田卓巳, 山田英之
- Organizer
  日本薬学会第1 27年会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-19390034
[Presentation] シトクロムP450 3A4 (CYP3A4)とUGT1Aサブファミリーの相互作用について(J. Health Sci.53, s-224 (2007))2007
- Author(s)
  追崎俊也, 竹田修三, 西村嘉雄, 田浦太志, 森元聡, 生城真一, Peter I. Mackenzie,, 永田清, 山添康, 石井祐次, 山田英之
- Organizer
  フォーラム2007 : 衛生薬学・環境トキシコロジー
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] Activation of Morphine UDPGlucuronosyltransferase by Fatty Acyl-CoAs. Abstracts of papers (Drug Metab. Rev. 39, 261-262(2007))2007
- Author(s)
  Arief Nurrochmad, Yuji Ishii, and Hideyuki Yamada
- Organizer
  8^<th> International ISSX meeting
- Place of Presentation
  Sendai, Japan
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] シトクロムP450 3A4 とUGT1A サブファミリーとのタンパク質間相互作用2007
- Author(s)
  追崎俊也, 竹田修三, 西村嘉雄, 田浦太志, 森元聡, 生城真一, Peter I. Mackenzie, 永田清, 山添康, 石井祐次, 山田英之
- Organizer
  第24日本薬学会九州支部大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] シトクロムP450 3A4(CYP3A4)とUDP-グルクロン酸転移酵素2B7 の相互作用に関与するCYP3A4 の領域とその役割(J.Toxicol. Sci. S92)2007
- Author(s)
  石井祐次、竹田修三、アリフヌロクマド、Peter I Mackenzie、永田清、山添康、小栗一太、山田英之
- Organizer
  第34回日本トキシコロジー学会学術年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] CytochromeP450とUDPGlucuronosyltransferase2B7の機能的相互作用について2007
- Author(s)
  石井祐次
- Organizer
  P450勉強会-UGT 研究会
- Place of Presentation
  富山(合同開催)
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] Interaction of Cytochrome P450 3A4 and UDPGlucuronosyltransferase 2B7 : Possible Involvement of a Region Located in the JHelix of CYP3A4 in the Interaction. Abstracts of papers(Drug Metab. Rev. 39, 301-302(2007))2007
- Author(s)
  Yuji Ishii, Shuso Takeda, Arief Nurrochmad, Yuki Iwamoto, Yuji Ito, Peter I. Mackenzie, Kiyoshi Nagata, Yasushi Yamazoe, Kazuta Oguri, and Hideyuki Yamada
- Organizer
  8^<th> International ISSX meeting
- Place of Presentation
  Sendai, Japan
- Data Source
  KAKENHI-PROJECT-19590147
[Presentation] Domains of UDP-glucuronosyltransferase serve in the functional interaction with cytochrome P450 3A4
- Author(s)
  Ishii Y, Miyauchi Y, Yamada H
- Organizer
  19th International Conference on Cytochrome P450
- Place of Presentation
  東京
- Year and Date
  2015-06-12 – 2015-06-15
- Invited
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] UDP-Glucuronosyltransferase 2B3 への N 型糖鎖付加配列導入が機能に及ぼす影響
- Author(s)
  山口奈穂, 中村達郎, 宮内優, 武田知起, マッケンジーピーター, 山田英之, 石井祐次
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] Functional interactions between cytochrome P450 and UDP-glucuronosyltransferase: a new insight into the inter-individual variation of drug metabolism.
- Author(s)
  Ishii Y, Miyauchi Y, Yamada H
- Organizer
  20th International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  スツットガルト, ドイツ
- Year and Date
  2014-05-18 – 2014-05-22
- Invited
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] Functional interaction between UDP-glucuronosyltransferase 2B3 (UGT2B3) and cytochrome P450 3A1 (CYP3A1): introduction of an N-glycosylation site to UGT2B3 alters the sensitivity of UGT2B3 to CYP3A1-dependent modulation
- Author(s)
  Nakamura T, Yamaguchi N, Miyauchi Y, Yamazoe Y, Nagata K, Mackenzie PI, Yamada H, Ishii Y
- Organizer
  12th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
- Place of Presentation
  京都
- Year and Date
  2014-09-24 – 2014-09-28
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] シトクロムP450 3A4 (CYP3A4)とUDP-グルクロン酸転移酵素 (UGT)の機能的相互作用: CYP3A4はUGT1A7遺伝的多型依存的にUGT機能を変動させる
- Author(s)
  江越菜月, 石井祐次, 木下亨佑, 古葉弘樹, 生城真一, 永田　清, 山添康, Peter I. Mackenzie, 山田英之
- Organizer
  フォーラム2014: 衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] シトクロム P450 3A4 による UDP-グルクロン酸転移酵素 1A7 バリアントの機能変動:W208R 変異は補酵素親和性の低下に関与しない
- Author(s)
  江越菜月, 木下亨佑, 古葉弘樹, 生城真一, 永田清, 山添康, マッケンジーピーター, 山田英之, 石井祐次
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25293039
[Presentation] Suppression of cytochrome P450 3A4 activity by UDP-glucuronosyltransferase (UGT) 2B7: the role of charged residue(s) in the cytosolic tail of UGT2B7.
- Author(s)
  Miyauchi Y, Ishii Y, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H
- Organizer
  19th North American ISSX/29th JSSX meeting
- Place of Presentation
  サンフランシスコ, 米国
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25293039

1. YAMADA Hideyuki (40142351)

# of Collaborated Projects: 3 results

# of Collaborated Products: 36 results
2. OGURI Kazuta (70037589)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 下條信弘 (00080622)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 山内博 (90081661)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 熊谷嘉人 (00250100)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 吉田貴彦 (90200998)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 相川浩幸 (40102850)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 宮内優 (50799947)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
9. ISHIDA Takumi (10301342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
10. 廣田有子 (50588259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Hidaka Kyoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 生城真一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 永田清

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Ishii Yuji 石井 祐次

ISHII Yuji 石井 祐次

Research Projects

Research Products

Co-Researchers

内外環境の破綻による次世代影響評価：発達障害と性未成熟の機構の検証と予防Principal Investigator

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Review Section

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内外環境の攪乱による次世代影響評価：発達障害と性成熟障害のメカニズムの検証と予防Principal Investigator

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Novel hypothesis for phenobarbital induction of drug metabolizing enzyme: Investigation of a model and a mechanismPrincipal Investigator

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Basic study for appropriate use of clinical medicine: functional interaction of drug metabolizing enzymes and its significance in vivoPrincipal Investigator

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Bas i s stud i es on the appropr i ate usage of c l i n i ca I med i c i ne : i so form specificity of the functional interaction between drug metabolizing enzymes and the individual differencesPrincipal Investigator

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Dioxin-induced imprinting of sexual immaturity and its mechanism

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Basic Studies on the appropriate usage of clinical narcotics : the individual differences in the formation of morphine active metabolite which is not dependent on the genetic polymorphismPrincipal Investigator

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Basic approach for good prescribing: Post-translational modulation of activities of drug-metabolizing enzymesPrincipal Investigator

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Evidence for functional interaction between phase I and phase II drug metabolizing enzymes

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AhレセプターとC/EBPのクロストークを介した肝特異的遺伝子発現の抑制Principal Investigator

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内モンゴルの慢性砒素汚染地域での介入研究

Principal Investigator

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中国の慢性砒素汚染地域での介入研究:生体内NO産生変動と中毒症状軽減との関係

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環境ホルモンコプラナーPCBによる細胞質チロシンホスファターゼの抑制メカニズムPrincipal Investigator

Principal Investigator

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Ishii Yuji 石井祐次

ISHII Yuji 石井祐次