Hokari Ryota 穂苅量太

… Alternative Names

穂苅量太ホカリリョウタ

穂刈量太ホカリリョウタ

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Researcher Number	90255464
Other IDs	https://orcid.org/0000-0002-8511-2540
Affiliation (Current)	2025: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 内科学, 教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 内科学, 教授 2016: 防衛医科大学, 内科学講座, 教授 1998: 慶應義塾大学, 医学部, 助手 1996 – 1997: 慶應義塾大学, 医学部, 内科助手
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Basic Section 38050:Food sciences-related / Gastroenterology
Keywords	Principal Investigator 生体顕微鏡 / リンパ管 / アクリジンオレンジ / パイエル板 / 局所注入 / バイエル板 / 流出機構 / リンパ球 / リンパ官 / ICAM-1 … More / 接着分子 / 血流速度 / shear rate / 腫瘍血管 / 腸間膜 / 腹膜播種 / 白血球 / 大腸癌 … More Except Principal Investigator 炎症性腸疾患 / 腸管炎症 / 腸内細菌叢 / 腸内細菌 / 乳化剤 / 抗炎症性サイトカイン / Th17細胞 / 炎症性サイトカイン / 消化器内科 / av/b8インテグリン / 活性化型TGF-b / 乳酸菌 / Treg細胞 / 制御性T細胞 / 樹状細胞 / 抗炎症作用 / プロバイオティクス / 発酵食品 Less

Analysis of mechanism for dietary emulsifying agents caused intestinal inflammatory
- Principal Investigator
  
  Kurihara Chie
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  National Defense Medical College
The mechanism of action of strong anti-inflammatory effects in novel Lactobacillus probiotic strains isolated from Japanese "Funazushi"
- Principal Investigator
  
  Okada Yoshikiyo
- Project Period (FY)
  2011 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  National Defense Medical College
腸リンパ装置におけるリンパ球の遊出(emigration)機構の解明Principal Investigator
- Principal Investigator
  
  穂苅量太 (穂刈量太)
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
大腸癌腸間膜播種モデルにおける腫瘍血管内皮ーリンパ球相互反応の生体観察Principal Investigator
- Principal Investigator
  
  穂苅量太
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] リンパ球マイグレーションを変化させる管腔内因子2022
- Author(s)
  東山正明, 澁谷尚希, 塙芳典, 古橋廣崇, 栗原千枝, 穂苅量太
- Journal Title
  
  リンパ学
  
  Volume: 45(2) Pages: 100-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05875
[Journal Article] Protective Effect of Luminal Uric acid Against Indomethacin-induced Enteropathy: Role of Antioxidant Effect and Gut Microbiota2021
- Author(s)
  Wada A; Higashiyama M.; Kurihara C.; Ito S.; Tanemoto R.; Mizoguchi A.; Nishii S.;Inaba K.; Sugihara N.; Hanawa .Y; Horiuchi K.; Shibuya N.; Akiyama M.; Okada Y.; Watanabe C.; Komoto S.; Tomita K.; Takei F.; Hokari R.
- Journal Title
  
  Digestive Diseases and Sciences.
  
  Volume: in press Issue: 1 Pages: 121-133
- DOI
  10.1007/s10620-021-06848-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05534, KAKENHI-PROJECT-19K05875, KAKENHI-PROJECT-18K07924
[Journal Article] Acesulfame potassium induces dysbiosis and intestinal injury with enhanced lymphocyte migration to intestinal mucosa2021
- Author(s)
  Hanawa Yoshinori、Higashiyama Masaaki、Kurihara Chie、Tanemoto Rina、Ito Suguru、Mizoguchi Akinori、Nishii Shin、Wada Akinori、Inaba Kenichi、Sugihara Nao、Horiuchi Kazuki、Okada Yoshikiyo、Narimatsu Kazuyuki、Komoto Shunsuke、Tomita Kengo、Hokari Ryota
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 36 Issue: 11 Pages: 3140-3148
- DOI
  10.1111/jgh.15654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05875
[Journal Article] Intestinal inflammations increase efflux of innate lymphoid cells from the intestinal mucosa to the mesenteric lymph nodes through lymph-collecting ducts2021
- Author(s)
  Kazuki Horiuchi, Masaaki Higashiyama, Chie Kurihara, Kouji Matsumura, Rina Tanemoto, Suguru Ito, Akinori Mizoguchi, Shin Nishii, Akinori Wada, Kenichi Inaba, Nao Sugihara, Yoshinori Hanawa, Kengo Tomita, Ryota Hokari
- Journal Title
  
  Microcirculation
  
  Volume: - Issue: 5
- DOI
  10.1111/micc.12694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05875, KAKENHI-PROJECT-18K07924
[Journal Article] Dietary emulsifier polysorbate‐80‐induced small‐intestinal vulnerability to indomethacin‐induced lesions via dysbiosis2019
- Author(s)
  Furuhashi Hirotaka、Higashiyama Masaaki、Okada Yoshikiyo、Kurihara Chie、Wada Akinori、Horiuchi Kazuki、Hanawa Yoshinori、Mizoguchi Akinori、Nishii Shin、Inaba Kenichi、Sugihara Nao、Watanabe Chikako、Komoto Shunsuke、Tomita Kengo、Miura Soichiro、Hokari Ryota
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 35 Issue: 1 Pages: 110-117
- DOI
  10.1111/jgh.14808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05875
[Presentation] THE IMPACT OF DIETARY EMULSIFIERS ON CHANGES OF MOUSE GUT MICROBIOTA AND INCREASED INTESTINAL PERMEABILITY DEPENDS ON HYDROPHILIC-LIPOPHILIC BALANCE2023
- Author(s)
  Chie Kurihara, Masaaki Higashiyama, Yuta Yoshidome, Hiroyuki Tahara, Kana Ayaki, Hiroyuki Nishimura, Akira Tomioka, Suguru Ito, Rina Tanemoto, Yoshikiyo Okada, Kazuyuki Narimatsu, Shunsuke Komoto, Kengo Tomita, Ryota Hokari
- Organizer
  Digestive Disease Week 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05875
[Presentation] 食品添加物として用いられる微量の乳化剤が腸粘膜バリアに与える影響について2021
- Author(s)
  穂苅量太
- Organizer
  第48回日本潰瘍学会
- Data Source
  KAKENHI-PROJECT-19K05875
[Presentation] Efficacy of Granulocyte and Monocyte Adsorptive Apheresis Treatment is Correlated with Colonic Mucosal Expression of Th17-asociated Cytokines in Ulcerative Colitis2020
- Author(s)
  Chie Kurihara, Toshihide Ohmor, iKenichi Inaba, Nao Sugihara, Yoshinori Hanawa, Kazuki Horiuchi, Ryota Hokari
- Organizer
  Digestive Disease Week 2020,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05875
[Presentation] Analysis of dietary emulsifier leading to change diversity of the gut microbiota and increased intestinal permeability2020
- Author(s)
  Chie Kurihara, Akinori Wada, Hirotaka Furuhashi, Masaaki Higashiyama, Ryota Hokari
- Organizer
  The 8th Annual Meeting of Asian Organization for Crohn's and Colitis (AOCC2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05875
[Presentation] DEOXYCHOLIC ACID ENHANCES INTESTINAL LYMPHOCYTE MIGRATION TO VASCULAR ENDOTHELIUM BY DIRECT INCREASE IN EXPRESSIONS OF ICAM-I AND VCAM-1 THROUGH SPHINGOSINE-1-PHOSPHATE RECEPTOR 22020
- Author(s)
  Naoki Shibuya, Masaaki Higashiyama, Shin Nishii, Akinori Mizoguchi, Chie Kurihara, Ryota Hokari
- Organizer
  Digestive Disease Week 2020,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05875
[Presentation] Higher TNFα and MIP-1β expression in pretreatment colonic mucosa have potential to predict of achieving mucosal healing by GMA therapy in ulcerative colitis patients2019
- Author(s)
  Chie Kurihara, Toshihide Ohmori, Hirotaka Furuhashi, IKenichi naba ,Nao Sugihara, Yoshinori Hanawa, Kazuki Horiuchi, Akinori Wada, Shin Nishii, Akinori Mizoguchi, Yoshikiyo Okada, Naoki Shibuya, Hideaki Hozumi, Masaaki Higashiyama, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita ,Ryota Hokari
- Organizer
  Digestive Disease Week 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05875
[Presentation] DISTINCTIVE SUBPOPULATION OF INNATE LYMPHOID CELLS EFFLUXED FROM INTESTINAL MUCOSA BY DIFFERENT INTESTINAL INFLAMMATIONS2019
- Author(s)
  Kazuki Horiuchi, Masaaki Higashiyama, Koji Matsumura, Hiroshi Ohno, Shin Nishii, Akinori Mizoguchi, Kenichi Inaba, Nao Sugihara, Yoshinori Hanawa, Akinori Wada, Hirotaka Furuhashi, Naoki Shibuya, Chie Kurihara, Yoshikiyo Okada, Hideaki Hozumi, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita, Ryota Hokari
- Organizer
  Digestive Disease Week 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05875
[Presentation] 乳化剤が腸管自然リンパ球に及ぼす影響の検討2019
- Author(s)
  堀内和樹、東山正明、西井慎、溝口明範、因幡健一、杉原奈央、塙芳典、和田晃典、古橋廣崇、澁谷尚希、栗原千枝、岡田義清、渡辺知佳子、高本俊介、冨田謙吾、穂苅量太
- Organizer
  第43回日本リンパ学会総会
- Data Source
  KAKENHI-PROJECT-19K05875
[Presentation] 伝統的発酵食品中に存在するプロバイオティクスの大腸炎治療への応用とその作用機序2014
- Author(s)
  岡田義清、都築義和、安武優一、丸田紘史、好川謙一、冨田謙吾、栗原千枝、高本俊介、渡辺知佳子、永尾重昭、三浦総一郎、穂苅量太
- Organizer
  第45回日本消化吸収学会総会
- Place of Presentation
  東京
- Year and Date
  2014-11-22
- Data Source
  KAKENHI-PROJECT-23590954
[Presentation] ふなずし由来新規ラクトバシラス属菌が有する強力な大腸炎抑制の作用機序2013
- Author(s)
  岡田義清、都築義和、佐藤宏和、成松和幸、安武優一、穂苅量太、冨田謙吾、栗原千枝、高本俊介、渡辺知佳子、永尾重昭、三浦総一郎
- Organizer
  第50回日本消化器免疫学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590954
[Presentation] Probiotics isolated from Funazushi modulates NK-1R expression in colonic epithelial cells in vitro and attenuated DSS-induced colitis.2013
- Author(s)
  Yoshikiyo Okada, Yoshikazu Tsuzuki, Hirokazu Sato, Kazuyuki Narimatsu, Yuichi Yasutake, Ryota Hokari, Kengo Tomita, Chie Kurihara, Shunsuke Komoto, Chikako Watanabe, Atsushi Kawaguchi, Shigeaki Nagao, Soichiro Miura
- Organizer
  Falk Symposium 188
- Place of Presentation
  ドイツ、シュツットガルト
- Data Source
  KAKENHI-PROJECT-23590954
[Presentation] A novel vegetable-derived probiotics (VDP) exerts a therapeutic effect on DSS induced colitis possibly mediated by IL-27 producing CD11c+ dendritic cells.2012
- Author(s)
  Yoshikiyo Okada, Yoshikazu Tsuzuki, Ryota Hokari, Chie Kurihara, Shunsuke Komoto, Chikako Watanabe, Kengo Tomita, Atsushi Kawaguchi, Shigeaki Nagao and Soichiro Miura
- Organizer
  米国消化器病学会週間(DDW2012)
- Place of Presentation
  米国サンディエゴ
- Data Source
  KAKENHI-PROJECT-23590954
[Presentation] A novel vegetable-derived probiotics (VDP) modulates proinflammatory cytokines and substance P expression on colonic tissue and attenuated DSS-induced colitis.2011
- Author(s)
  Yoshikiyo Okada, Yoshikazu Tsuzuki, Ryota Hokari, Soichiro Miura et al.
- Organizer
  米国消化器病学会週間(DDW2011)
- Place of Presentation
  米国シカゴ
- Data Source
  KAKENHI-PROJECT-23590954
[Presentation] A novel probiotics isolated from Japanese "Funazushi" potently exerts a therapeutic effect on DSS-induced colitis
- Author(s)
  Yoshikiyo Okada, Yoshikazu Tsuzuki, Hirokazu Sato, Kazuyuki Narimatsu, Yuichi Yasutake, Koji Maruta, Kengo Tomita, Chikako Watanabe, Shunsuke Komoto, Chie Kurihara, Shingo Usui, Shigeaki Nagao, Soichiro Miura and Ryota Hokari
- Organizer
  第56回日本消化器病学会大会(JDDW2014)
- Place of Presentation
  神戸
- Year and Date
  2014-10-23 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-23590954
[Presentation] 伝統的発酵食品由来プロバイオティクスのDSS腸炎に対する抗炎症作用の検討
- Author(s)
  岡田義清、都築義和、安武優一、丸田紘史、好川謙一、冨田謙吾、栗原千枝、高本俊介、渡辺知佳子、永尾重昭、三浦総一郎、穂苅量太
- Organizer
  第11回日本消化管学会総会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-02-13 – 2015-02-14
- Data Source
  KAKENHI-PROJECT-23590954

1. Okada Yoshikiyo (90531137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. Miura Soichiro (50138012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. Tsuzuki Yoshikazu (10236929)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. Kurihara Chie (90532515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
5. 武井史恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hokari Ryota 穂苅 量太

穂苅 量太 ホカリ リョウタ

穂刈 量太 ホカリ リョウタ

Research Projects

Research Products

Co-Researchers

Analysis of mechanism for dietary emulsifying agents caused intestinal inflammatory

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of action of strong anti-inflammatory effects in novel Lactobacillus probiotic strains isolated from Japanese "Funazushi"

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腸リンパ装置におけるリンパ球の遊出(emigration)機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

大腸癌腸間膜播種モデルにおける腫瘍血管内皮ーリンパ球相互反応の生体観察Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] リンパ球マイグレーションを変化させる管腔内因子2022

Author(s)

Journal Title

Data Source

[Journal Article] Protective Effect of Luminal Uric acid Against Indomethacin-induced Enteropathy: Role of Antioxidant Effect and Gut Microbiota2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acesulfame potassium induces dysbiosis and intestinal injury with enhanced lymphocyte migration to intestinal mucosa2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intestinal inflammations increase efflux of innate lymphoid cells from the intestinal mucosa to the mesenteric lymph nodes through lymph-collecting ducts2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dietary emulsifier polysorbate‐80‐induced small‐intestinal vulnerability to indomethacin‐induced lesions via dysbiosis2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] THE IMPACT OF DIETARY EMULSIFIERS ON CHANGES OF MOUSE GUT MICROBIOTA AND INCREASED INTESTINAL PERMEABILITY DEPENDS ON HYDROPHILIC-LIPOPHILIC BALANCE2023

Author(s)

Organizer

Data Source

[Presentation] 食品添加物として用いられる微量の乳化剤が腸粘膜バリアに与える影響について2021

Author(s)

Organizer

Data Source

[Presentation] Efficacy of Granulocyte and Monocyte Adsorptive Apheresis Treatment is Correlated with Colonic Mucosal Expression of Th17-asociated Cytokines in Ulcerative Colitis2020

Author(s)

Organizer

Data Source

[Presentation] Analysis of dietary emulsifier leading to change diversity of the gut microbiota and increased intestinal permeability2020

Author(s)

Organizer

Data Source

[Presentation] DEOXYCHOLIC ACID ENHANCES INTESTINAL LYMPHOCYTE MIGRATION TO VASCULAR ENDOTHELIUM BY DIRECT INCREASE IN EXPRESSIONS OF ICAM-I AND VCAM-1 THROUGH SPHINGOSINE-1-PHOSPHATE RECEPTOR 22020

Author(s)

Organizer

Data Source

[Presentation] Higher TNFα and MIP-1β expression in pretreatment colonic mucosa have potential to predict of achieving mucosal healing by GMA therapy in ulcerative colitis patients2019

Author(s)

Organizer

Data Source

[Presentation] DISTINCTIVE SUBPOPULATION OF INNATE LYMPHOID CELLS EFFLUXED FROM INTESTINAL MUCOSA BY DIFFERENT INTESTINAL INFLAMMATIONS2019

Author(s)

Hokari Ryota 穂苅量太

穂苅量太ホカリリョウタ

穂刈量太ホカリリョウタ