Kinoshita Kosaku 木下浩作

… Alternative Names

KINOSHITA Kosaku 木下浩作

木下浩作キノシタコウサク

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Researcher Number	90260968
Other IDs
External Links
Affiliation (Current)	2025: 日本大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 日本大学, 医学部, 教授 2016 – 2017: 日本大学, 医学部, 教授 2016: 日本大学, 医学部附属板橋病院, 教授 2006 – 2011: Nihon University, School of Medicine, Associate Professor, 医学部, 准教授 2006: 日本大学, 医学部, 助教授 2005: 日本大学, 医学部, 講師(専任扱) 1994: 日本大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Emergency medicine / Basic Section 55060:Emergency medicine-related / Cerebral neurosurgery Except Principal Investigator Basic Section 55060:Emergency medicine-related / Applied health science / Emergency medicine
Keywords	Principal Investigator サイトカイン / 敗血症 / 高血糖 / Tumor necrotic factor-alpha / 高温 / 二次性脳損傷 / 脳機能障害 / 転帰 / バイオマーカー / 脳萎縮 … More / 抗炎症作用 / 虚血再灌流傷害 / 5-アミノレブリン酸 / 抗炎症効果 / アミノレブリン酸 / Cytokine / Endothelial injury / Traumatic brain injury / Hyperglycemia / Lipopolysaccharide / 血管内皮障害 / 外傷 / 頭部外傷 / interleukin (IL)-8 / 炎症 / IL-6 / interleukin(IL)-8 / ヒト臍帯静脈血管内皮細胞 / 多臓器不全 / 糖 / lipopolysaccharide / 血管内皮細胞 / antagonist / cytochrome oxidase / excitatory amino acid / unilateral hemispheric swelling / acute subdural hematoma / ischemia / brain edema / trauma … More Except Principal Investigator 敗血症 / 自動瞳孔計 / 予後予測 / HRV / バイタルサイン / 分時換気量 / 自律神経反応 / ポータブル自動瞳孔計 / 重症敗血症 / 筋萎縮性側索硬化症（ALS） / 筋萎縮性側索硬化症（ALS / オレイン酸 / パルミトレイン酸 / 血漿遊離脂肪酸量 / 酸化型コエンザイムQ10の割合 / 遊離脂肪酸量 / 活性酸素 / ALS / 心肺停止救急患者 / プロサポシン / 尿酸 / 遊離脂肪酸 / コエンザイムQ10 / 酸化ストレス / mRNAの安定性 / interleukin (IL)-6 / interleukin (IL)-8 / 人臍帯血内皮細胞 / サイトカイン / 低温 / mRNA安定性 / IL-8 / LPS / 炎症 / 長期低温 / 内皮細胞 Less

自動瞳孔計を用いた敗血症患者の急性期自律神経反応解析と転帰予測
- Principal Investigator
  
  山口順子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Nihon University
Study for the mechanism of brain dysfunction in patient with post intensive care syndrome after sepsisPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Kosaku
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Nihon University
Anti-inflammatory effect of 5-aminolevulinic acid in patients with the sepsis and/or ischemic reperfusion injury.Principal Investigator
- Principal Investigator
  
  KINOSHITA Kosaku
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Nihon University
Age-dependent changes of risk factors determining the survival of patients
- Principal Investigator
  
  YAMAMOTO Yorihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo University of Technology
Anti-inflammatory effect of hyperthermia on endothelial cells-temperature dependency and systemic responsePrincipal Investigator
- Principal Investigator
  
  KINOSHITA Kosaku
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Nihon University
Implication for long-term hypothermia of degradation of cytokine mRNA in endothelial cells stimulated with lipopolysaccharides
- Principal Investigator
  
  SAKURAI Atsushi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Nihon University
Endothelial injury induce by hyperthermia Effect of hyperglycemic conditionPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Kosaku
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Nihon University
Interleukin-8 production from human umbilical vein endothelial cells during brief hyperglycemia : The effect of tumor necrotic factor alphaPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Kosaku
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Nihon University
急性硬膜下血腫におけるHemispheric Swellingの発生機序に関する研究-興奮性アミノ酸の関与と細胞エネルギー需要の亢進-Principal Investigator
- Principal Investigator
  
  木下浩作
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Nihon University

All 2023 2022 2021 2020 2017 2015 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] "The eyes are the windows of the soul": Portable automated pupillometry to monitor autonomic nervous activity in CO2 narcosis: A case report.2023
- Author(s)
  Yamaguchi J, Kinoshita K, Hosokawa T, Ihara S
- Journal Title
  
  Medicine（Baltimore）
  
  Volume: 102(19) Issue: 19 Pages: e33768-e33768
- DOI
  10.1097/md.0000000000033768
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09195
[Journal Article] Undernutrition Scored Using the CONUT Score with Hypoglycemic Status in ICU-Admitted Elderly Patients with Sepsis Shows Increased ICU Mortality2023
- Author(s)
  Junko Yamaguchi, Kosaku Kinoshita, Katsuhiro Nakagawa, Minori Mizuochi
- Journal Title
  
  Diagnostics
  
  Volume: 13 Issue: 4 Pages: 762-762
- DOI
  10.3390/diagnostics13040762
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09195
[Journal Article] Oxidative Stress and Abnormal Cholesterol Metabolism in Patients with Post-cardiac Arrest Syndrome2017
- Author(s)
  Nagase M, Sakurai A, Sugita A, Matsumoto N, Kubo A, Miyazaki Y, Kinoshita K, Yamamoto Y
- Journal Title
  
  J Clin Biochem Nutr
  
  Volume: -
- NAID
  130006038751
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26350915
[Journal Article] Changes caused by hypothermia in interleukin-8 mRNA stability in human endothelial cells stimulated by lipopolysaccharide2010
- Author(s)
  Atsushi Sakurai, Kosaku Kinoshita, Rikimaru Kogawa, Tsukasa Kuwana, Takashi Moriya, Akihiro Noda, Katsuhisa Tanjoh
- Journal Title
  
  Critical Care Medicine 37巻12号(suppl)
- Data Source
  KAKENHI-PROJECT-20592129
[Journal Article] Hyperglycemia Increases Lipopolysaccharide (LPS) induced Interleukin-8 (IL-8) Expression From Endothelial Cells2007
- Author(s)
  Noda A, Kinoshita K, Sakurai A, Utagawa A, Yoshida, Tanjoh K
- Journal Title
  
  Critical Care Medicine (supplement) 34
- Data Source
  KAKENHI-PROJECT-17591897
[Journal Article] Acceleration of chemokine production from endothelial cells in response to lipopolysaccharide in hyperglycemic condition.2006
- Author(s)
  Kinoshita K, Furukawa M, Ebihara T, Sakurai A, Noda A, Kitahata Y, Utagawa A, Tanjoh K
- Journal Title
  
  Acta Neurochir Suppl. 96
  
  Pages: 419-421
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591897
[Journal Article] Acceleration of chemokine production from endothelial cells in response to lipopolysaccharide in hyperglycemic condition.2006
- Author(s)
  Kinoshita K, Furukawa M, Ebihara T, Sakurai A, Noda A, Kitahata Y, Utagawa A, Tanjoh K:
- Journal Title
  
  Acta Neurochirurgica Supplement 96
  
  Pages: 419-421
- Data Source
  KAKENHI-PROJECT-17591897
[Journal Article] 脳損傷時の生体反応2006
- Author(s)
  木下浩作, 櫻井淳, 古川誠, 吉田省造, 北畑有司, 野田彰浩, 山口順子, 海老原貴之, 丹正勝久, 林成之
- Journal Title
  
  脳死脳蘇生 18
  
  Pages: 41-45
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591897
[Journal Article] 脳低温療法の適応と管理上の注意点2006
- Author(s)
  木下浩作
- Journal Title
  
  医学のあゆみ 216
  
  Pages: 193-197
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591897
[Journal Article] Interleukin-8 production from human umbilical vein endothelial cells during brief hyperglycemia : The effect of tumor necrotic factor alpha
- Author(s)
  Kinoshita K, Tanjoh, K, Noda A, Sakurai A, Yamaguchi J, Azuhata T, Utagawa, A, Moriya T
- Journal Title
  
  J Surg Res. (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591897
[Journal Article] Interleukin-8 production from human umbilical vein endothelial cells during brief hyperglycemia : The effect of tumor necrotic factor alpha
- Author(s)
  Kinoshita K, Tanjoh, K, Noda A, Sakurai A, Yamaguchi J, Azuhata T, Utagawa, A, Moriya T.
- Journal Title
  
  Journal of Surgical Research (In press)
- Data Source
  KAKENHI-PROJECT-17591897
[Journal Article] Interleukin-8 production from human umbilical vein endothelial cells during brief hyperglycemia : The effect of tumor necrotic factor alpha
- Author(s)
  Kinoshita K, Tanjoh, K, Noda A, Sakurai A, Yamaguchi J, Azuhata T, Utagawa, A, Moriya T.
- Journal Title
  
  J Surg Res. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591897
[Presentation] 敗血症患者の退院時転帰不良は低血圧の日数と相関する2022
- Author(s)
  井口梅文，中川勝寛，細川透，伊原慎吾，木下浩作
- Organizer
  第49回日本集中治療医学会
- Data Source
  KAKENHI-PROJECT-19K09425
[Presentation] 敗血症患者に認めた急性期頭部MRI異常の検討2022
- Author(s)
  細川透，中川勝寛，井口梅文，山口順子，木下浩作
- Organizer
  第49回日本集中治療医学会
- Data Source
  KAKENHI-PROJECT-19K09425
[Presentation] 敗血症患者の神経学的転帰悪化は低血圧の持続と相関する2022
- Author(s)
  井口梅文，中川勝寛，細川透，伊原慎吾，木下浩作
- Organizer
  第49回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09425
[Presentation] 小児における急性脳症と熱性痙攣重積症の早期鑑別が可能かポータブル自動瞳孔計による検討2022
- Author(s)
  細川透　山口順子　木下浩作
- Organizer
  第36回日本神経救急医学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09195
[Presentation] ポータブル自動瞳孔計による瞳孔反応測定値を用いた中毒診療の可能性2022
- Author(s)
  山口順子細川透伊原慎吾櫻井淳木下浩作
- Organizer
  第50回日本救急医学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09195
[Presentation] 敗血症患者に認めた急性期頭部MRI異常の検討2022
- Author(s)
  細川透，中川勝寛，井口梅文，山口順子，木下浩作
- Organizer
  第49回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09425
[Presentation] 敗血症患者に発生する急性期脳萎縮/脳室拡大と臨床的意義2021
- Author(s)
  細川透, 松岡俊, 井口梅文, 伊原慎吾, 桑名司, 山口順子, 木下浩作
- Organizer
  第48回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09425
[Presentation] 敗血症患者に発生する急性期脳萎縮/脳室拡大と臨床的意義2020
- Author(s)
  細川透, 松岡俊, 井口梅文, 伊原慎吾, 桑名司, 山口順子, 木下浩作
- Organizer
  第48回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09425
[Presentation] Oxidative stress and abnormal cholesterol metabolism in patients with sepsis2015
- Author(s)
  Nagase M, Yamaguchi J, Sakurai A, Kinoshita K, Yamamoto Y
- Organizer
  Joint Meeting of the Societies for Free Radical Research Australasia and Japan
- Place of Presentation
  Christchurch, New Zealand
- Year and Date
  2015-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350915
[Presentation] Post-inhibitory augmentation of cytokine production after a transient hyperthermia stimuli2011
- Author(s)
  Kinoshita K
- Organizer
  The 4^<th> International Hypothermia Symposium
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-21592315
[Presentation] 高温環境における血管内皮細胞サイトカイン産生能の低下とリバウンド効果2011
- Author(s)
  木下浩作, 古川力丸, 野田彰浩, 山口順子, 杉田篤紀, 古川誠, 雅楽川聡, 守谷俊, 櫻井淳, 丹正勝久
- Organizer
  第38回日本集中治療医学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21592315
[Presentation] Post-inhibitory augmentation of cytokine production after a transient hyperthermia stimuli2011
- Author(s)
  Kinoshita K, Kogawa R, Sakurai A, Yamaguchi J, Utagawa A, Kuwana T, Furukawa M, Moriya T, Sugita A, Tanjoh K
- Organizer
  The 4th International Hypothermia Symposium Tokyo
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-21592315
[Presentation] Rebound effect of cytokine production after a transient hyperthermia stimuli2010
- Author(s)
  木下浩作
- Organizer
  39^<th> Critical care congress
- Place of Presentation
  Miami, Florida
- Year and Date
  2010-01-11
- Data Source
  KAKENHI-PROJECT-21592315
[Presentation] Rebound effect of cytokine production after a transient hyperthermia stimuli2010
- Author(s)
  Kinoshita K, Sakurai A, Kogawa R, Kuwana T, Yamaguchi J, Furukawa M Sugita A, Mukoyama T, Utagawa A, Tanjoh K
- Organizer
  39th Critical care congress
- Place of Presentation
  Miami, Florida
- Data Source
  KAKENHI-PROJECT-21592315
[Presentation] 高温下における炎症性サイトカイン発現からみた高糖環境制御の重要性2009
- Author(s)
  雅楽川聡、木下浩作、野田彰浩、櫻井淳、丹正勝久
- Organizer
  第36回日本集中治療医学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19592100
[Presentation] Hyperthemia inhibits cytokine production by endothelial cells2009
- Author(s)
  Kinoshita K, Sakurai A, Mukoyama T, Noda A, Kogawa R, Yamaguchi J, Azuhata T, Utagawa A, Moriya T, Tanjoh K
- Organizer
  38th Critical care congress
- Place of Presentation
  Nashville, Tennessee
- Data Source
  KAKENHI-PROJECT-19592100
[Presentation] 高温環境における血管内皮細胞サイトカイン産生の変化2009
- Author(s)
  木下浩作, 櫻井淳, 野田彰浩, 雅楽川聡, 向山剛生, 古川力丸, 多田勝重, 千葉宣孝, 丹正勝久
- Organizer
  第37会日本救急医学会総会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-21592315
[Presentation] Hyperthemia inhibits cytokine production by endothelial cells.2009
- Author(s)
  Kinoshita K, Sakurai A, Mukoyama T, Noda A, Kogawa R, Yamaguchi J, Azuhata T, Utagawa A, Moriya T, Tanjoh K
- Organizer
  38^<th> Critical care congress
- Place of Presentation
  Nashville, Tennessee
- Data Source
  KAKENHI-PROJECT-19592100
[Presentation] Hyperthermia accelerates the production of Lipopolysaccharide (LPS) induced cytokine production from endothelial cells in a hyperglycemic condition2008
- Author(s)
  Kinoshita K, Sakurai A, Mukoyama T, Noda A, Kogawa R, Yamaguchi J, AzuhataT, Utagawa A, Moriya T, Tanjoh K
- Organizer
  37th Critical care congress
- Place of Presentation
  Hawaii, Honolulu
- Data Source
  KAKENHI-PROJECT-19592100
[Presentation] Hyperthermia accelerates the production of Lipopolysaccharide(LPS)induced cytokine production from endothelial cells in a hyperglycemic condition2008
- Author(s)
  Kosaku Kinoshita, Noda A, Sakurai A, et. al.
- Organizer
  37th Critical care congress
- Place of Presentation
  Hawaii, Honolulu
- Data Source
  KAKENHI-PROJECT-19592100
[Presentation] 高温環境下の炎症性サイトカイン発現に対する高糖環境制御の重要性2008
- Author(s)
  雅楽川聡、木下浩作、野田彰浩、櫻井淳、丹正勝久
- Organizer
  第36会日本救急医学会総
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19592100

1. SAKURAI Atsushi (40339320)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
2. 堀智志 (10811581)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 山口順子 (50570511)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. UTAGAWA Akira (70328730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. YAMAMOTO Yorihiro (60134475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 加柴美里 (80338186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 千葉宣孝 (30535175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 杉田篤紀 (70599745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IHARA Shingo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kinoshita Kosaku 木下 浩作

KINOSHITA Kosaku 木下 浩作

木下 浩作 キノシタ コウサク

Research Projects

Research Products

Co-Researchers

自動瞳孔計を用いた敗血症患者の急性期自律神経反応解析と転帰予測

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study for the mechanism of brain dysfunction in patient with post intensive care syndrome after sepsisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Anti-inflammatory effect of 5-aminolevulinic acid in patients with the sepsis and/or ischemic reperfusion injury.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Age-dependent changes of risk factors determining the survival of patients

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Anti-inflammatory effect of hyperthermia on endothelial cells-temperature dependency and systemic responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Implication for long-term hypothermia of degradation of cytokine mRNA in endothelial cells stimulated with lipopolysaccharides

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Endothelial injury induce by hyperthermia Effect of hyperglycemic conditionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interleukin-8 production from human umbilical vein endothelial cells during brief hyperglycemia : The effect of tumor necrotic factor alphaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

急性硬膜下血腫におけるHemispheric Swellingの発生機序に関する研究-興奮性アミノ酸の関与と細胞エネルギー需要の亢進-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] "The eyes are the windows of the soul": Portable automated pupillometry to monitor autonomic nervous activity in CO2 narcosis: A case report.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Undernutrition Scored Using the CONUT Score with Hypoglycemic Status in ICU-Admitted Elderly Patients with Sepsis Shows Increased ICU Mortality2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oxidative Stress and Abnormal Cholesterol Metabolism in Patients with Post-cardiac Arrest Syndrome2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Changes caused by hypothermia in interleukin-8 mRNA stability in human endothelial cells stimulated by lipopolysaccharide2010

Author(s)

Journal Title

Data Source

[Journal Article] Hyperglycemia Increases Lipopolysaccharide (LPS) induced Interleukin-8 (IL-8) Expression From Endothelial Cells2007

Kinoshita Kosaku 木下浩作

KINOSHITA Kosaku 木下浩作

木下浩作キノシタコウサク

[Presentation] 小児における急性脳症と熱性痙攣重積症の早期鑑別が可能かポータブル自動瞳孔計による検討2022