KOBAYASHI Hiroshi 小林博司

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KOBAYASHI H. 小林博司

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Researcher Number	90266619
Other IDs
External Links
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 東京慈恵会医科大学, 医学部, 教授 2012 – 2020: 東京慈恵会医科大学, 医学部, 准教授 2007 – 2011: 東京慈恵会医科大学, 医学部, 講師 2002: 慈恵医大, 医学部, 助手 1999 – 2001: 東京慈恵会医科大学, 医学部, 助手 1999: 東京慈恵会医科大学, 小児科学教室, 助手 1996 – 1998: 東京慈恵会医科大学, 医学部・小児科, 助手
Review Section/Research Field	Principal Investigator Pediatrics / Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Pediatrics / Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator 遺伝子治療 / GALC / クラッベ病 / Krabbe病 / 神経系初代培養細胞 / Sly病 / シュードタイプ / 遺伝子解析 / 人工知能 / 倫理委員会 … More / 二次的ゲノム変化 / データベース / ＡＩ / ファブリー病 / 予後予測因子 / CAGE / 循環器系合併症 / 次世代シークエンサー / AI / Fabry病 / iPS細胞を分化させて / 遺伝子編集 / 自家移植 / デバイス / ジンクフィンガー / 治療用デバイス / ムコ多糖症 / 遺伝子改変 / 神経系起源基細胞 / 神経細胞デバイス / 治療補助用デバイス / 神経系スフェア / ＭＰＳ / iPS細胞 / Ｋｒａｂｂｅ病 / ｚｉｎｃ　ｆｉｎｇｅｒ / Zinc Finger / GFP / レンチウイルス / レンチウイルスベクター / 先天異常学 / 遺伝 / バキュロウイルスシステム / バキュロウイルス / 筋芽細胞 / 肝脾臓細胞 / アデノウイルス / β-glucuronidase / ムコ多糖症VII型(Sly病) … More Except Principal Investigator 遺伝子治療 / ライソゾーム病 / 免疫寛容 / 酵素補充療法 / GM1ガングリオシドーシス / 抗体 / アデノ随伴ウイルスベクター / アデノウイルスベクター / AAV / MPS VII / gene therapy / Sly disease / Sly病 / beta-glucuronidase / レンチウイルスベクター / ポンペ病 / 抗CD3抗体 / ポンぺ病 / ファブリー病 / MPSII / ムコ多糖症II型 / 予防法の開発 / 網羅的解析 / 加齢性難聴 / 早期難聴発症モデル / 内耳障害 / 血液脳関門 / ガラクトシルセラミダーゼ / ＧＭ１ガングリオシドーシス / 造血幹細胞 / GM1ガングリオシド―シス / 先天代謝異常学 / 遺伝・先天異常学 / 先天代謝異常 / 先天代謝異常症 / 遺伝・先天異常 / lysosomal disorder / mutation / Twitcher マウス / Twitcherマウス / ミクログリア / Cytkine / Adenovirus Vector / Niemann-Pick Disease TypeC / Neural progenitor / Nieman-Pick病typeC / Niemann-Pick病type C / サイトカイン / レトロウイルス / β-galactosidase / Nieman-Pick病type C / Gene Therapy / MPSVII / アデノ随伴ウイルス / retrovirus / Macrophage / ムコ多糖症 / β-glucuronidase / Sly病(Sly disease) / 遺伝子導入 / Slyマウス / レトロウイルスベクター / マクロファージ / レンチウイルス / イズロン酸サルファターゼ / 骨質系 / 骨芽細胞 / Ｈｕｎｔｅｒ　ｓｙｎｄｒｏｍｅ / 骨代謝 / 病理 / 骨病変 / ムコ多糖症Ⅱ型 / 免疫寛容療法 / 経口投与 / ライソゾーム病蓄積症 / 制御性T細胞 / 免疫応答 / アナフィラキシー / ライソゾーム蓄積症 / 酵素補充湯療法 Less

血液脳関門を克服するGM1ガングリオシドーシスへの遺伝子治療法の開発
- Principal Investigator
  
  角皆季樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Jikei University School of Medicine
BBB通過型GALC発現AAVベクターはクラッベ病マウスの寿命延長効果を持つか
- Principal Investigator
  
  樋口孝
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Jikei University School of Medicine
早期難聴発症モデルにおける内耳障害の病態メカニズムの解明と予防法の開発
- Principal Investigator
  
  中澤宝
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Jikei University School of Medicine
ヒト型受容体介在性トランスサイトーシスを利用したライソゾーム病遺伝子治療法の開発
- Principal Investigator
  
  松島小貴
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Jikei University School of Medicine
Hematopoietic stem cell gene therapy using engineered enzyme with high penetrating ability for mucopolysaccharidosis type II
- Principal Investigator
  
  SHIMADA Yohta
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Jikei University School of Medicine
Development of Hematopoietic Stem Targeted Gene Therapy for GM1-gangliosidosis
- Principal Investigator
  
  Ohashi Toya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Jikei University School of Medicine
Integrated database construction of Fabry disease using artificial intelligence / next generation sequencerPrincipal Investigator
- Principal Investigator
  
  Kobayashi Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Jikei University School of Medicine
Development of efficient enzyme replacement therapy for lysosomal storage disease with immune modulation
- Principal Investigator
  
  Ohashi Toya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Preparation of device for mucopolysaccharidosis treatment using iPS cells and gene modification systemPrincipal Investigator
- Principal Investigator
  
  Kobayashi Hiroshi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Analysis of the Pathophysiological Mechanism of Bone Lesion in Mucopolysaccharidosis Mouse Model ; Its Natural History and Therapeutic Effect
- Principal Investigator
  
  Ida Hiroyuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Development of effective treatment by immune tolerance induction in enzyme replacement therapy for lysosomal storage diseases
- Principal Investigator
  
  OHASHI TOYA
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Gene Therapy for the Krabbe disease using zinc finger nuclease systemPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Hiroshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Anti-CD3 antibody induced immune tolerance to infused enzyme in enzyme replacement therapy for lysosomal storage disease
- Principal Investigator
  
  ETO Yoshikatsu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Lentiviral vector mediated gene therapy for Krabbe diseasePrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Immune tolerance induction in enzyme replacement therapy for lysosomal storage diseases
- Principal Investigator
  
  ETO Yoshikatsu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
シュードタイプ・バキュウロウイルスベクターを用いたSly病マウスの遺伝子治療Principal Investigator
- Principal Investigator
  
  小林博司
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
シュードタイプ・バキュウロウイルスベクターを用いたSly病マウスの遺伝子治療Principal Investigator
- Principal Investigator
  
  小林博司
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Gene Therapy for Sly disease using AAV vector.
- Principal Investigator
  
  OHASHI Touya
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
Treatment for congenital metabolic disorder with brain dysfunction.
- Principal Investigator
  
  TOKORO Toshiharu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
Gene therapy for Krabbe disease with microglial cells derived from brain
- Principal Investigator
  
  GOMIBUCHI Ichizou
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
Gene therapy for Sly disease
- Principal Investigator
  
  OHASHI T.
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
筋肉細胞を標的としたリソゾーム蓄積症の遺伝子治療の開発Principal Investigator
- Principal Investigator
  
  小林博司
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine

All 2023 2022 2021 2017 2016 2014 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Patent

[Journal Article] A novel preclinical model of mucopolysaccharidosis type II for developing human hematopoietic stem cell gene therapy2023
- Author(s)
  Shimada Y, Ishii N, Higuchi T, Goto M, Ohashi T, Kobayashi H
- Journal Title
  
  Gene Therapy
  
  Volume: 30 Issue: 3-4 Pages: 288-296
- DOI
  10.1038/s41434-022-00357-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08262
[Journal Article] Pathology of the First Autopsy Case Diagnosed as Mucolipidosis type III alpha/beta Suggesting Autophagic Dysfunction2011
- Author(s)
  Kobayashi H, Eto Y, et al
- Journal Title
  
  Mol Genet Metab
  
  Volume: 102 Pages: 170-175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591333
[Journal Article] Minimum requirement of donor cells to reduce the glycolipid storage following bone marrow transplantation in a murine model of Fabry disease2011
- Author(s)
  Yokoi T, Kobayashi H, Shimada Y, Eto Y, Ishige N, Kitagawa T, Otsu M, Nakauchi H, Ida H, Ohashi T
- Journal Title
  
  J Gene Med
  
  Volume: 13 Issue: 5 Pages: 262-8
- DOI
  10.1002/jgm.1566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591333, KAKENHI-PROJECT-23659533
[Journal Article] Oral administration of recombinant human acid alpha -glucosidase reduces specific antibody formation against enzyme in mouse2011
- Author(s)
  Ohashi T, Iizuka S, Shimada Y, Eto Y, Ida H, Hachimura S, Kobayashi H
- Journal Title
  
  Mol Genet Metab
  
  Volume: 103 Pages: 98-100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591333
[Journal Article] Neonatal gene transfer using lentiviral vector for murine Pompe disease : long term expression and glycogen reduction.2010
- Author(s)
  Kyosen OS, Iizuka S, Kobayashi H, Kimura T, Fukuda T, Shen JS, Shimada Y, Ida H, Eto Y
- Journal Title
  
  Gene Therapy
  
  Volume: 17 Pages: 521-530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591333
[Journal Article] Non-invasive high-risk screening for Fabry disease hemizygotesand heterozygotes.2008
- Author(s)
  Kitagawa T, Suzuki K, Ishige N, Ohashi T, Kobayashi M, Eto Y, Tanaka A, Odaka H, Owada M.
- Journal Title
  
  Pediatr Nephrol. 23
  
  Pages: 461-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591223
[Journal Article] Clinical manifestations and natural history of Japanese heterozygous females with Fabry disease.2008
- Author(s)
  Kobayashi M, Ohashi T, Sakuma M, Ida H, Eto Y.
- Journal Title
  
  J Inherit Metab Dis. Jan 21(Online Report)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591223
[Journal Article] Administration of anti-CD3 antibodies modulates the immune response to an infusion of alpha-glucosidase in mice
- Author(s)
  Toya Ohashi, Sayoko Iizuka, Yohta Shimada, Takashi Higuchi, Yoshikatsu Eto, Hiroyuki Ida, Hiroshi Kobayashi
- Volume
  (投稿中)
- Data Source
  KAKENHI-PROJECT-21591333
[Patent] 中枢神経系疾患の治療のための、核酸分子、ベクター、組換え細胞及び薬剤2022
- Inventor(s)
  木下正文、高木春奈、薗田啓之、嶋田洋太、小林博司、他
- Industrial Property Rights Holder
  JCRファーマ株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-110492
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-19K08262
[Presentation] 血液脳関門通過型酵素を発現するAAVによるGM1ガングリオシドーシスの遺伝子治療.2023
- Author(s)
  松島小貴, 飯塚佐代子, 木下正文, 高木春奈, 飯塚俊輔, 樋口孝, 嶋田洋太, 薗田啓之, 大橋十也, 小林博司.
- Organizer
  第64回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07808
[Presentation] 血液脳関門通過型酵素発現AAVによるライソゾーム病中枢神経症状に対する遺伝子治療.2023
- Author(s)
  松島小貴, 飯塚佐代子, 木下正文, 高木春奈, 飯塚俊輔, 大月孝太, 今給黎厚志, 樋口孝, 嶋田洋太, 薗田啓之, 大橋十也, 小林博司.
- Organizer
  第29回日本遺伝子細胞治療学会学術集会.
- Data Source
  KAKENHI-PROJECT-21K07808
[Presentation] Gene therapy for GM1 gangliosidosis mediated by AAV vector carrying BBB-penetrable enzyme.2023
- Author(s)
  Saki Matsushima, Sayoko Iizuka, Masafumi Kinoshita, Haruna Takagi, Shunsuke Iizuka, Kota Ohtsuki, Atsushi Imakiire, Shinichiro Okamoto, Takashi Nagashima, Takashi Higuchi, Yohta Shimada, Hiroyuki Hioki, Hiroyuki Sonoda, Ayako M. Watabe, Toya Ohashi, Hiroshi Kobayashi.
- Organizer
  American Society of Gene and Cell Therapy 26th Annual meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07808
[Presentation] Application of a novel murine model of mucopolysaccharidosis type II for developing human hematopoietic stem cell gene therapy2022
- Author(s)
  Shimada Y, Ishii N, Higuchi T, Goto M, Ohashi T, Kobayashi H
- Organizer
  25th Annual Meeting of The American Society of Gene and Cell Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08262
[Presentation] Gene therapy for GM1 gangliosidosis mediated by AAV vector carrying BBB-penetrable enzyme.2022
- Author(s)
  Matsushima S, Iizuka S, Kinoshita M, Takagi H, Nagashima T, Shimada Y, Sonoda H, Watabe M. A, Ohashi T, Kobayashi H.
- Organizer
  第63回日本先天代謝異常学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07808
[Presentation] 中枢神経移行型酵素を搭載したAAVによるGM1ガングリオシドーシスへの遺伝子治療2022
- Author(s)
  松島小貴、飯塚佐代子、木村文香、嶋田洋太、角皆季樹、木下正文、高木春奈、飯塚俊輔、大月孝太、今給黎厚志、樋口孝、薗田啓之、大橋十也、小林博司
- Organizer
  第28回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07808
[Presentation] Analysis of human hematopoietic stem cell gene therapy using mucopolysaccharidosis type II mice2021
- Author(s)
  Shimada Y, Ishii N, Higuchi T, Ohashi T, Kobayashi H
- Organizer
  第62回日本先天代謝異常学会
- Data Source
  KAKENHI-PROJECT-19K08262
[Presentation] MPS II型もdルマウス脳病変における、免疫寛容導入療法併用大量酵素補充療法の効果2017
- Author(s)
  横井健太郎、横井貴之、嶋田洋太、樋口孝、小林博司、大橋十也、井田博幸
- Organizer
  日本先天代謝異常学会
- Data Source
  KAKENHI-PROJECT-15K09600
[Presentation] ムコ多糖症モデルマウスの骨病変の分子・病理学的解析2017
- Author(s)
  和田美穂、小林博司、斎藤充、井田博幸　など
- Organizer
  第121回　日本小児科学会
- Place of Presentation
  東京
- Year and Date
  2017-04-14
- Data Source
  KAKENHI-PROJECT-26461533
[Presentation] Gene Therapy and Gene Editing for Lysosomal Storage diseases2017
- Author(s)
  小林博司、飯塚佐代子、有賀賢典、福田隆浩、嶋田洋太、樋口孝、岩本武夫、Katherine Ponder, Mark Haskns, 大橋十也
- Organizer
  The 23rd Annual Meeting of Japan Society of Gene and Cell Therapy
- Data Source
  KAKENHI-PROJECT-15K09601
[Presentation] Gene Therapy and Gene Editing for Lysosomal Storage Disease2017
- Author(s)
  小林博司
- Organizer
  第17回日本遺伝子細胞治療学会
- Place of Presentation
  岡山
- Year and Date
  2017-07-20
- Data Source
  KAKENHI-PROJECT-15K09601
[Presentation] ムコ多糖症モデルマウスの骨病変の病理・分子生物学的解析2016
- Author(s)
  和田美穂、小林博司、斎藤充、井田博幸　など
- Organizer
  第５８回　日本先天代謝異常学会
- Place of Presentation
  東京
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-26461533
[Presentation] Lentiviral Mediated Gene Therapy & Zinc Finger Nucrease Mediated Gene Editing for Krabbe disease2016
- Author(s)
  小林博司
- Organizer
  第16回日本遺伝子細胞治療学会
- Place of Presentation
  東京
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-15K09601
[Presentation] GENE THERAPY FOR KRABBE DISEASE USING THE SYSTEM OF LENTIVIRAL VECTOR AND ZINC FINGER NUCLEASE2014
- Author(s)
  Hiroshi Kobayashi, Masamichi Ariga, Yohei Sato, Taichi Wakabayashi, Yota Shimada, Takashi Higuchi, Sayoko Iizuka, Yoshikatsu Eto, Toya Ohashi
- Organizer
  日本遺伝子治療学会
- Place of Presentation
  東京慈恵会医科大学講堂
- Data Source
  KAKENHI-PROJECT-24591527
[Presentation] PO-76. Recombinant lentivirus mediated gene therapy for neonatal mouse model of Krabbe disease2012
- Author(s)
  Kobayashi H., Shimada Y., Ariga M., Izuka S., Sato Y., Iwamoto T., Fukuda T., Eto Y., Ohashi T.
- Organizer
  日本遺伝子治療学会
- Place of Presentation
  熊本テルサ
- Data Source
  KAKENHI-PROJECT-24591527
[Presentation] Anti-CD3 antibody reduces antibody formation and prevents lethal hypersensitivity reaction in enzyme replacement therapy for murinelysosomal storage diseases2011
- Author(s)
  Ohashi T, Iizuka S, Shimada Y, Eto Y, Ida H, Kobayashi H
- Organizer
  11th International Symposium on Lysosomal Storage Diseases
- Place of Presentation
  Madrid
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] Anti-CD3 antibody reduces antibody formation and prevents lethal hypersensitivity reaction in enzyme replacement therapy for Pompe disease in mouse2011
- Author(s)
  Ohashi T, Iizuka S, Shimada Y, Ida H, Eto Y, Kobayashi H
- Organizer
  Annual Symposium of the Society for the Study of Inborn Errors of Metabolism
- Place of Presentation
  Geneva, Switzerland
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] Anti-CD3 antibody reduces antibody formation and prevents lethal hypersensitivitv reaction in enzyme replacement therapy for murinelysosomal storage diseases2011
- Author(s)
  Ohashi T, Iizuka S, Shimada Y, Eto Y, Ida H, Kobayashi H
- Organizer
  11th International Symposium on Lysosomal Storage Diseases
- Place of Presentation
  Madrid, Spain(招待講演)
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] ライソゾーム病酵素補充療法における酵素製剤に対する免疫反応に関する研究2011
- Author(s)
  大橋十也、飯塚佐代子、嶋田洋太、樋口孝、井田博幸、衛藤義勝、小林博司
- Organizer
  第53回日本先天代謝異常学会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] 日本人Fabry病家系の遺伝子変異についての研究遺伝子変異と臨床病型について2010
- Author(s)
  小林正久、大橋十也、井田博幸、衞藤義勝
- Organizer
  日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] MPSII型Knockoutマウスでの脳室内酵素治療に関する研究2010
- Author(s)
  樋口孝、清水寛美、河越しほ、福田隆浩、小林博司、井田博幸、大橋十也、平戸徹、西野勝哉、衞藤義勝
- Organizer
  日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] 抗CD3抗体によるポンペ病酵素補充療法での酵素製剤に対する免疫寛容導入2010
- Author(s)
  大橋十也, 飯塚佐代子, 衛藤義勝, 嶋田洋太, 井田博幸, 小林博司
- Organizer
  第52回日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] 濾紙血を用いたPompe病スクリーニング法の有用性と問題点2010
- Author(s)
  清水寛美、嶋田洋太、若林太一、小林博司、大橋十也、井田博幸、川井充、衞藤義勝
- Organizer
  日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] ポンペ病細胞におけるオートファジー活性化の分子機序2010
- Author(s)
  嶋田洋太、西山由梨佳、小林博司、衞藤義勝、井田博幸、大橋十也
- Organizer
  日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] レンチウイルスベクターシステムを用いたクラッベ病の遺伝子治療2010
- Author(s)
  小林博司, ほか
- Organizer
  第113回日本小児科学会
- Place of Presentation
  盛岡
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-20591233
[Presentation]2010
- Author(s)
  Kobayashi H., Ariga M., et al.
- Organizer
  16^<th> Japanese Society of Gen and Cell Therapy.
- Place of Presentation
  Tochigi., Japan
- Year and Date
  2010-07-01
- Data Source
  KAKENHI-PROJECT-20591233
[Presentation] 新生児MPS VIIマウスへの遺伝子治療におけるレンチウイルスベクタの長期発現2010
- Author(s)
  有賀賢典、小林博司、飯塚佐代子、金城栄子、清水寛美、衞藤義勝、大橋十也、井田博幸
- Organizer
  日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] ファブリ病モデルマウスに対する骨髄移植におけるキメリズムの決定2010
- Author(s)
  横井貴之、小林博司、衞藤義勝、石毛信之、北川照男、大津真、中内啓光、大橋十也、井田博幸
- Organizer
  日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation]2010
- Author(s)
  小林博司、有賀賢典, ほか
- Organizer
  第113回日本小児科学会
- Place of Presentation
  盛岡
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-20591233
[Presentation] Neonatal Gene Therapy for the mouse model of Krabbe Disease.2010
- Author(s)
  Kobayashi_H., Ariga M., et al.
- Organizer
  16^<th> Japanese Society of Gene and Cell Therapy
- Place of Presentation
  Tochigi, Japan
- Year and Date
  2010-07-01
- Data Source
  KAKENHI-PROJECT-20591233
[Presentation] Immune tolerance induction in enzyme replacement therapy for Pompe disease by anti-CD3 antibody and oral enzyme administration2009
- Author(s)
  Ohashi T, Iizuka S, Kobayashi H, Shimada Y, Eto Y, Ida Y
- Organizer
  The 3th Internationl Symposium of Lysosomal Storage Diseases
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] Pompe病の酵素補充療法における酵素製剤に対する免疫寛容導入2009
- Author(s)
  大橋十也、飯塚佐代子、嶋田洋太, 小林博司, 衞藤義勝, 井田博幸
- Organizer
  第51回日本先天代謝異常学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] Immune tolerance induction in enzyme replacement therapy for Pompe disease by anti-CD3 antibody and oral enzyme administration.2009
- Author(s)
  Ohashi T, lizuka S, Kobayashi H, Shimada Y, Eto Y, Ida H.
- Organizer
  The 3^<th> Internationl Symposium of Lysosomal Storage Diseases.
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] GeneTherapy for Krabbe disease using the system of lentiviral vector and zinc finger nuclease
- Author(s)
  Hiroshi Kobayashi、Masamichi Ariga, Yohei Sato, Taichi Wakabayashi, Yota Shimada et al.
- Organizer
  第20回　日本遺伝子治療学会
- Place of Presentation
  東京都、慈恵医大講堂
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-24591527
[Presentation] Gene Therapy for Krabbe Disease Using the System of Lentiviral Vector and Zinc Finger Nucrease
- Author(s)
  Hiroshi Kobayashi
- Organizer
  The 4th Asian Congress For Inherited Metabolic Diseases
- Place of Presentation
  台北市　EICC
- Year and Date
  2015-03-19 – 2015-03-22
- Data Source
  KAKENHI-PROJECT-24591527
[Presentation] 免疫寛容導入による効果的ポンペ病酵素補充療法の開発
- Author(s)
  大橋十也　嶋田洋太　樋口孝　飯塚佐代子　井田博幸　衞藤義勝　小林博司
- Organizer
  第56回日本先天代謝異常学会
- Place of Presentation
  仙台
- Year and Date
  2014-11-13 – 2014-11-15
- Data Source
  KAKENHI-PROJECT-24591526

1. OHASHI TOYA (60160595)

# of Collaborated Projects: 10 results

# of Collaborated Products: 6 results
2. SHIMADA Yohta (20560824)

# of Collaborated Projects: 9 results

# of Collaborated Products: 13 results
3. ETO Yoshikatsu (50056909)

# of Collaborated Projects: 7 results

# of Collaborated Products: 22 results
4. HIGUCHI Takashi (30595327)

# of Collaborated Projects: 7 results

# of Collaborated Products: 6 results
5. Ida Hiroyuki (90167255)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
6. 岩澤京子 (10301524)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 松島小貴 (80451871)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. KOBAYASHI Masahisa (20312019)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
9. TAJIMA Asako (00328337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KIMURA Takahiro (00307430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAWAI Toshinao (20328305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MAEDA Kazuhiro (50548849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TOKORO Toshiharu (40112841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ONO Tsuneya (60147288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. GOMIBUCHI Ichizou (50205621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 齋藤充 (50301528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 横井健太郎 (20459655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 渡部文子 (00334277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 福田隆浩 (60228913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 中澤宝 (40892245)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 三瓶紗弥香 (20622301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 高橋恵里沙 (20875546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 櫻井結華 (50307427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 宇田川友克 (60328292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 角皆季樹 (60816635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. WADA Miho

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
27. KONDO Saki

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
28. 斉藤充

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

KOBAYASHI Hiroshi 小林 博司

KOBAYASHI H. 小林 博司

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Integrated database construction of Fabry disease using artificial intelligence / next generation sequencerPrincipal Investigator

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Preparation of device for mucopolysaccharidosis treatment using iPS cells and gene modification systemPrincipal Investigator

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Gene Therapy for the Krabbe disease using zinc finger nuclease systemPrincipal Investigator

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Lentiviral vector mediated gene therapy for Krabbe diseasePrincipal Investigator

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KOBAYASHI Hiroshi 小林博司

KOBAYASHI H. 小林博司