• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

WATANABE MARIKO  渡邉 真理子

ORCIDConnect your ORCID iD *help
… Alternative Names

WATANABE Mariko  渡邉 真理子

Less
Researcher Number 90270701
Affiliation (Current) 2025: 北里大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help 2019 – 2022: 北里大学, 医療衛生学部, 助教
2016 – 2017: 北里大学, 医療衛生学部, 助教
2014 – 2015: 北里大学, 大学病院, 臨時職員
2013: 北里大学, 大学病院, 研究技能員
2011 – 2013: 北里大学, 大学病院, その他
Review Section/Research Field
Principal Investigator
Human pathology / Basic Section 49020:Human pathology-related
Except Principal Investigator
Basic Section 49020:Human pathology-related
Keywords
Principal Investigator
EBウイルス / リンパ芽球様細胞株 (LCL) / CD30 / ホジキンリンパ腫 / LMP-1 / リンパ芽球様細胞株(LCL) / Epstein-Barr(EB)ウイルス / リンパ増殖性疾患 / リンパ芽球様細胞株 / RNA Sequence … More / CGH 法 / CD30L / Epstein-Barr ウイルス / CD30 ligand / RNAシークエンス / アレイCGH法 / LCL / ゲノム異常 / Epstein-Barr (EB) ウイルス / リンパ芽球様細胞株(LCL) / Epstein―Barr virus (EBV) / Hodgkinリンパ腫 / CD0 / EB ウイルス / Epstein-Barr virus (EBV) / 分子標的療法 / 細胞分化 / ニッチ / 癌幹細胞 … More
Except Principal Investigator
腫瘍化 / ゲノム異常 / chromosomal instability / flower cell / Tax / PD-L1 / PI3K / ROS / genomic instability / ATL / HTLV-1 / CD30 Less
  • Research Projects

    (4 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (5 People)
  •  Genomic instability and tumorigenesis by CD30 in HTLV-1-infected cells

    • Principal Investigator
      Horie Ryouichi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Kitasato University
  •  Genomic abnormalities by CD30 and their roles in the tumorigenic process of Epstein-Barr virus-infected cellsPrincipal Investigator

    • Principal Investigator
      WATANABE Mariko
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Kitasato University
  •  Analyses of molecular pathogenesis of Hodgkin lymphoma by transformation of B cells and humanized mice modelPrincipal Investigator

    • Principal Investigator
      WATANABE Mariko
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Kitasato University
  •  Analyses of molecular bases of cancer stem cells and their differentiation in Hodgkin lymphomaPrincipal Investigator

    • Principal Investigator
      WATANABE MARIKO
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Kitasato University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Patent

  • [Journal Article] Differentiation of Hodgkin lymphoma cells by reactive oxygen species and regulation by heme oxygenase‐1 through HIF‐1α2021

    • Author(s)
      Nakashima Makoto、Watanabe Mariko、Nakano Kazumi、Uchimaru Kaoru、Horie Ryouichi
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 6 Pages: 2542-2555

    • DOI

      10.1111/cas.14890

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K16580, KAKENHI-PROJECT-19K07442, KAKENHI-PROJECT-20K07379
  • [Journal Article] Jietacins, azoxy natural products, as novel NF-kB inhibitors: discovery, synthesis, biological activity, and mode of action2019

    • Author(s)
      Mariko Watanabe, Akihiro Sugawara, Yoshihiko Noguchi, Tomoyasu Hirose, Satoshi Omura, Toshiaki Sunazuka, Ryouichi Horie
    • Journal Title

      Eur. J. Med. Chem.

      Volume: 178 Pages: 636-647

    • DOI

      10.1016/j.ejmech.2019.05.079

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06586, KAKENHI-PROJECT-19K07442, KAKENHI-PROJECT-19K16318, KAKENHI-PROJECT-17K08728
  • [Journal Article] Trogocytosis of ligand-receptor complex and its intracellular transport in CD30 signalling.2018

    • Author(s)
      Nakashima M, Watanabe M, Uchimaru K, Horie R.
    • Journal Title

      Biol Cell.

      Volume: 110 Issue: 5 Pages: 1-16

    • DOI

      10.1111/boc.201800002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26460439, KAKENHI-PROJECT-16H06277
  • [Journal Article] CD30 induces heat shock protein 90 and signal integration in classic Hodgkin lymphoma cells2017

    • Author(s)
      Watanabe M, Nakano K, Kadin ME, Higashihara M, Watanabe T, Horie R
    • Journal Title

      Am J Pathol

      Volume: 187 Issue: 1 Pages: 163-175

    • DOI

      10.1016/j.ajpath.2016.09.007

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460440, KAKENHI-PROJECT-26460439
  • [Journal Article] Brefeldin A exerts differential effects on anaplastic lymphoma kinase positive anaplastic large cell lymphoma and classical Hodgkin lymphoma cell lines2015

    • Author(s)
      Toda T, Watanabe M, Kawato J, Kadin ME, Higashihara M, Kunisada T, Umezawa K, and Horie R
    • Journal Title

      Br J Haematol

      Volume: in press

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460439
  • [Journal Article] Brefeldin A exerts differential effects on anaplastic lymphoma kinase positive anaplastic large cell lymphoma and Hodgkin lymphoma cell lines.2015

    • Author(s)
      T. Toda, M. Watanabe, J. Kawato, M. Higashihara, T. Kunisada, K. Umezawa and R. Horie
    • Journal Title

      British J. Haematology

      Volume: 170 Issue: 6 Pages: 837-846

    • DOI

      10.1111/bjh.13508

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26350975, KAKENHI-PROJECT-26460439, KAKENHI-PROJECT-26460440
  • [Journal Article] Combined inhibition of NF-κB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells2014

    • Author(s)
      Watanabe M, Umezawa K, Higashihara M, Horie R.
    • Journal Title

      Oncol Res

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590432
  • [Journal Article] Activation of Akt involves resistance to NF-κB inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells2014

    • Author(s)
      Togano T, Watanabe M, Itoh K, Umezawa K, Masuda N, Higashihara M, Horie R
    • Journal Title

      Lung Cancer

      Volume: 83 Issue: 2 Pages: 139-145

    • DOI

      10.1016/j.lungcan.2013.10.018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590432, KAKENHI-PROJECT-23590433
  • [Journal Article] Combined inhibition of NF-κB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells2014

    • Author(s)
      Watanabe M, Umezawa K, Higashihara M, Horie R
    • Journal Title

      Oncol Res.

      Volume: 21(4) Issue: 4 Pages: 173-80

    • DOI

      10.3727/096504014x13887748696707

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590432, KAKENHI-PROJECT-23590433
  • [Journal Article] Targeted Repression of Overexpressed CD30 Downregulates NF-κB and ERK1/2 Pathway in Hodgkin Lymphoma Cell Lines2012

    • Author(s)
      Watanabe M, Nakano K, Togano T, Nakashima M, Higashihara M, Kadin M.E., Watanabe, T, Horie R
    • Journal Title

      Oncol Res.

      Volume: 19(10-11) Pages: 463-9

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22715589

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590432
  • [Journal Article] Surface CD3 expression proceeds through both myosin regulatory light chain 9 (MYL9)-dependent and MYL9-independent pathways in Jurkat cells2012

    • Author(s)
      Aoki T, Miyazaki K, Katayama T, Watanabe M, Horie R, Danbara M, Higashihara M
    • Journal Title

      J Smooth Muscle Res.

      Volume: 48(5-6) Pages: 137-47

    • NAID

      10031151480

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/23538510

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590432
  • [Journal Article] Synergistic effect of 5-azacytidine and NF-κB inhibitor DHMEQ on apoptosis induction in myeloid leukemia cells2012

    • Author(s)
      Togano T, Nakashima M, Watanabe M,Umezawa K, Watanabe T, Higashihara M, Horie R
    • Journal Title

      Oncol Res.

      Volume: 20(12) Issue: 12 Pages: 571-7

    • DOI

      10.3727/096504013x13775486749371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590432, KAKENHI-PROJECT-23590433
  • [Journal Article] Ets-1 activates overexpression of JunB and CD30 in Hodgkin's lymphoma and anaplastic large-cell lymphoma2012

    • Author(s)
      Watanabe M, Itoh K, Togano T, Kadin ME, Watanabe T, Higashihara M, Horie R
    • Journal Title

      Am J Pathol

      Volume: 180(2) Issue: 2 Pages: 831-8

    • DOI

      10.1016/j.ajpath.2011.10.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590432, KAKENHI-PROJECT-23590433
  • [Journal Article] Surface CD3 expression proceeds through both myosin regulatory light chain 9 (MYL9)-dependent and MYL9-independent pathways in Jurkat cells.2012

    • Author(s)
      Aoki T, Miyazaki K, Katayama T, Watanabe M, Horie R, Danbara M, Higashihara M.
    • Journal Title

      J Smooth Muscle Res.

      Volume: 48(5-6) Pages: 137-47

    • NAID

      10031151480

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590432
  • [Journal Article] Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB2012

    • Author(s)
      Takeiri, M., Horie, K., Takahashi, D., Watanabe, M., Horie, R., Simizu, S. & Umezawa, K
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 10 Issue: 15 Pages: 3053-3059

    • DOI

      10.1039/c2ob07104e

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-23590432, KAKENHI-PROJECT-23590433
  • [Journal Article] The side population, as a precursor of Hodgkin and Reed-Sternberg cells and a target for nuclear factor-κB inhibitors in Hodgkin's lymphoma2011

    • Author(s)
      Nakashima M, Ishii Y, Watanabe M, Togano T, Umezawa K, Higashihara M, Watanabe T, Horie R
    • Journal Title

      Cancer Sci

      Volume: 101(11) Issue: 11 Pages: 2490-6

    • DOI

      10.1111/j.1349-7006.2010.01693.x

    • NAID

      10027834044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590432, KAKENHI-PROJECT-23590433
  • [Journal Article] Re-appearance of hepatitis B virus following therapy with rituximab for lymphoma is not rare in Japanese patients with past hepatitis B virus infection2011

    • Author(s)
      Watanabe M, Shibuya A, Tsunoda Y, Danbara M, Ishii R, Ohsaka M, Takada J, Tanaka Y, Okuwaki Y, Minamino T, HidakaH, Nakazawa T, Horie R, Higashihara M, Koizumi W
    • Journal Title

      Liver Int.

      Volume: 31(3) Issue: 3 Pages: 340-7

    • DOI

      10.1111/j.1478-3231.2010.02417.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590432, KAKENHI-PROJECT-23590433
  • [Patent] 新規 NF-κB 阻害剤2017

    • Inventor(s)
      渡邉真理子 他6名
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-181123
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-26460439
  • [Presentation] CD30シグナルが誘導する染色体不安定性の促進機構2022

    • Author(s)
      中島誠,宇都宮與,渡邉俊樹,堀江良一,内丸薫
    • Organizer
      第81回日本癌学会学術総会 横浜
    • Data Source
      KAKENHI-PROJECT-20K07379
  • [Presentation] 成人T細胞白血病リンパ腫においてCD30シグナルは染色体不安定性を高める2021

    • Author(s)
      中島 誠、宇都宮與、渡邉俊樹、堀江 良一、内丸 薫
    • Organizer
      第83回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07379
  • [Presentation] ホジキンリンパ腫細胞のROSによる分化とHIF-1αを介したヘムオキシダーゼ1による分化制御2020

    • Author(s)
      中島 誠、渡邉 真理子、中野 和民、内丸 薫、堀江 良一
    • Organizer
      第82回日本血液学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K07379
  • [Presentation] 古典的 Hodgkin リンパ腫における CD30 を介した HSP90 誘導シグナル伝達制御機構の解析2017

    • Author(s)
      渡邉真理子、東原正明、堀江良一
    • Organizer
      第64回日本臨床検査医学会学術集会
    • Data Source
      KAKENHI-PROJECT-26460439
  • [Presentation] Internalization of ligand-receptor complex and its intracellular transport in CD30 signaling2017

    • Author(s)
      Makoto Nakashima, Mariko Watanabe, Kaoru Uchimaru, Ryouich Horie
    • Organizer
      第79回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-26460439
  • [Presentation] 古典的Hodgkinリンパ腫におけるCD30を介したHSP90誘導とシグナル統合機構の解析2016

    • Author(s)
      堀江良一、渡邉真理子、内丸薫、中野和民、Marsha ll E. Kadin、、渡邉俊樹、東原正明
    • Organizer
      第56回日本リンパ網内系学会
    • Place of Presentation
      ホテル日航熊本(熊本県熊本市)(誌上発表)
    • Year and Date
      2016-09-01
    • Data Source
      KAKENHI-PROJECT-26460439
  • [Presentation] 成人T細胞性白血病におけるCD30陽性集団に高倍数体細胞は出現する2016

    • Author(s)
      中島誠、矢持忠徳、渡邉真理子、内丸薫、宇都宮與、東原正明、渡 邉俊樹、堀江良一
    • Organizer
      第3回日本HTLV-1学会学術集会
    • Place of Presentation
      鹿児島県市町村自治会館(鹿児島県鹿児島市)
    • Year and Date
      2016-08-26
    • Data Source
      KAKENHI-PROJECT-26460439
  • [Presentation] The emergence of hyperploid cells in CD30+ subpopulation of adult T-cell leukemia.2016

    • Author(s)
      Makoto Nakashima, Tadanori Yamochi, Ma riko Watanabe, Atae Utsunomia, Masaaki Higashihara, Kaoru Uchimaru, Toshiki Watanabe, Ryouichi Horie
    • Organizer
      第78回日本血液学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-26460439
  • [Presentation] Differential effects of Brefeldin A on anaplastic large cell lymphoma and Hodgkin lymphoma2015

    • Author(s)
      堀江良一、戸田崇史、渡邉真理子、河戸淳仁、Marshall E. Kadin、梅澤一夫、東原正明
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      石川県・金沢市
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-26460439
  • [Presentation] ALK陽性未分化大細胞型リンパ腫と古典的Hodgkinリンパ腫細胞株に対して異なる感受性を示す薬剤の探索とBrefeldin Aの同定2015

    • Author(s)
      堀江良一、戸田崇史、渡邉真理子、河戸淳仁、梅澤一夫、東原正明
    • Organizer
      第54回日本リンパ網内系学会総会
    • Place of Presentation
      岡山県・岡山市
    • Year and Date
      2015-06-21
    • Data Source
      KAKENHI-PROJECT-26460439
  • [Presentation] Hodgkinリンパ腫と未分化大細胞型リンパ腫におけるCD30過剰発現機構の解析2013

    • Author(s)
      堀江良一, 渡邉真理子, 伊藤金次, 栂野富輝, KADIN Marshall E, 渡邉俊樹, 東原正明
    • Organizer
      第53回日本リンパ網内系学会総会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23590432
  • [Presentation] CD30 repression triggers global gene responses and anti-proliferative effects in Hodgkin lymphoma2013

    • Author(s)
      堀江良一, 渡邉真理子, 中野和民, 栂野富輝, Marshall E. Kadin, 渡邉俊樹, 東原正明
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2013-10-12
    • Data Source
      KAKENHI-PROJECT-23590432
  • [Presentation] The function of small RNAs conjugated in exosome in inflammatory niche of EBV positive lymphoma2012

    • Author(s)
      Ai Kotani, Jen Lu, Toshiki Watanabe, Ryoichi Horie, Kiyoshi Ando, Naoya Nakamura
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2012-10-20
    • Data Source
      KAKENHI-PROJECT-23590432
  • [Presentation] Molecular mechanisms of CD30 overexpression in Hodgkin’s lymphoma and anaplastic large-cell lymphoma2012

    • Author(s)
      Ryouichi Horie, Mariko Watanabe, Kinji Itoh, Tomiteru Togano, Marshall E. Kadin, Toshiki Watanabe, Masaaki Higashihara
    • Organizer
      日本血液学会 第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23590432
  • [Presentation] Hodgkinリンパ腫と未分化大細胞性リンパ腫におけるCD30過剰発現機構の解析2012

    • Author(s)
      堀江良一, 渡邉真理子, 伊藤金次, 栂野富輝, Kdin E Marshall, 渡邉俊樹, 東原正明
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2012-10-21
    • Data Source
      KAKENHI-PROJECT-23590432
  • [Presentation] EBV陽性リンパ腫微小環境における分泌性EBVコードmiRNA2011

    • Author(s)
      井上優希, 中村直哉, 阿部幸一郎, 豊嶋孝恵, 堀江良一, 渡邉俊樹, 安藤潔, 幸谷愛
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Data Source
      KAKENHI-PROJECT-23590432
  • [Presentation] Side populationはHodgkin,Reed‐Sternberg細胞の前駆細胞集団でNF‐κB阻害薬DHMEQの標的となる。2011

    • Author(s)
      堀江良一, 中島誠, 石井有実子, 渡邉真理子, 栂野富輝, 渡邉俊樹, 梅澤一夫, 東原正明
    • Organizer
      第51回日本リンパ網内系学会総会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23590432
  • [Presentation] Hodgkinリンパ腫の前駆細胞における分子基盤の解析と分子標的療法の基礎的検討2011

    • Author(s)
      堀江良一, 中島誠, 渡邉真理子, 栂野冨輝, 梅澤一夫, 渡邉俊樹, 東原正明
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Data Source
      KAKENHI-PROJECT-23590432
  • [Presentation] Hodgkinリンパ腫の前駆細胞における分子基盤の解析と分子標的療法の基礎的検討2011

    • Author(s)
      堀江良一、中島誠、渡邉真理子、栂野冨輝、梅澤一夫、渡邉俊樹、東原正明
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-23590432
  • [Presentation] CD30 repression triggers global gene responses and anti-proliferative effects in Hodgkin lymphoma

    • Author(s)
      堀江良一、渡邉真理子、中野和民、栂野富輝、Marshall E. Kadin、渡邉俊樹、東原正明
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23590432
  • [Presentation] Hodgkinリンパ腫と未分化大細胞型リンパ腫におけるCD30過剰発現機構の解析

    • Author(s)
      堀江良一、渡邉真理子、伊藤金次、栂野富輝、KADIN Marshall E、渡邉俊樹、東原正明
    • Organizer
      第53回日本リンパ網内系学会総会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23590432
  • 1.  HORIE Ryouichi (80229228)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 34 results
  • 2.  中島 誠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  廣瀬 友靖
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  清水 史郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  梅沢 一夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi