higashi tatsuya 東達也

… Alternative Names

HIGASHI Tatuya 東達也

HIGASHI Tatsuya 東達也

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Researcher Number	90272963
Other IDs
External Links
Affiliation (Current)	2025: 東京理科大学, 薬学部薬学科, 教授
Affiliation (based on the past Project Information) *help	2016 – 2023: 東京理科大学, 薬学部薬学科, 教授 2011 – 2016: 東京理科大学, 薬学部, 教授 2013: 東京理科大学, 薬学部薬学科, 教授 2008 – 2010: 静岡県立大学, 薬学部, 准教授 2008: Kanazawa University, 薬学系, 准教授 … More 2007: Kanazawa University, Graduate School of Natural Science and Technology, Associate Professor 2004 – 2006: Kanazawa University, Graduate School of Natural Science and Technology, Associate Professor, 自然科学研究科, 助教授 2003: 金沢大学, 薬学部, 助教授 2002: 金沢大学, 薬学部, 講師 1996 – 1998: Fac.Pharm.Sci., Kanazawa Univ., 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Physical pharmacy / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Physical pharmacy Except Principal Investigator Laboratory medicine / Physical pharmacy / Urology / Basic Section 52010:General internal medicine-related / Physical pharmacy / Eating habits, studies on eating habits
Keywords	Principal Investigator 誘導体化 / 分析科学 / 臨床検査 / LC/ESI-MS/MS / 骨粗鬆症 / MS / LC-MS / エストラジオール / 原発性アルドステロン症 / ハイスループット … More / LC / バイオマーカー / 検出指向誘導体化 / 胆汁酸 / アンドロゲン / MS/MS断片化 / 母骨格特異イオン / 診断マーカー / 加齢男性性腺低下症候群 / ビタミンD / MSタグ / LC/MS / ステロイドホルモン / 検体・項目多重化 / ビタミンD欠乏症 / 25-ヒドロキシビタミンD3 / HPA軸 / アナログ/アイソトポログ / グルタル酸血症 / 副腎過形成症 / 17α-ヒドロキシプロゲステロン / ハイスループット化 / 多検体一括 / アイソトポログ / アナログ / 質量分析 / Antipsychotic agent / Rat brain / Stress / Derivatization / Neurosteroid / エタノール / 抗不安・鎮静作用 / GABA_A受容体 / コルチコイド / 神経活性アンドロゲン / 向精神病薬 / ラット脳 / ストレス / 神経ステロイド / ultramicro analysis / in vitro assay for bone metabolism / hydroxysteroid dehydrogenase / derivatization / C-3 epimerization / osteoporosis / vitamin D_3 / 中間体 / ヒドロキシステロイド脱水素酵素 / 電子捕獲APCI-MS / 破骨細胞 / 骨芽細胞 / キンギョウロコ / 24,25-ジヒドロキシビタミンD_3 / 超微量分析 / in vitro骨代謝アッセイ / ヒドキシステロイド脱水素酵素 / 3位異性化 / ビタミンD_3 / アロプレグナノロン / 向精神薬 / 重水素標識 / ESI増強 / 誘導体化試薬 / 創薬 / ビタミンD代謝物 / 精神・神経疾患 / LC/MS/MS / ESI増強重水素標識試薬 / 神経活性ステロイド / 先天性副腎過形成症 / s-cis-ジエン / ビシナルジオール / キラル分離 / 潜在的ビタミンD欠乏症 / LCHAD欠損症 / Smith-Lemli-Opitz症候群 / ESIラベル化 / 高感度 / 精密検査 / 多点分子認識 / 先天性代謝異常症 / 臨床応用 / 先天性副腎過形成 / 肝胆道系疾患 / 加齢男性性腺機能低下症候群 / バセドウ病 / チロキシン / プロゲステロン / カルボン酸 / LC-MS/MS / 高速液体クロマトグラフィー-タンデム質量分析 / 無侵襲 / ホルモン検査 / 唾液 … More Except Principal Investigator MS / LC-MS/MS / LC / 前立腺癌 / 臨床検査 / 同時定量 / Estrogen / Vitamin D / GC / エストロゲン / 再燃前立腺癌 / アンドロゲン / 再燃 / 間質細胞 / プロテオーム / 薬剤反応性 / 自動化 / Androgen / LC/MS/MS / ホルモン / 臨床化学 / 誘導体化 / ビタミンD代謝物 / inhibitor / mass-screening / deivatization-LC / dihydrotestosterone / testosterone / bio-marker / benign prostatic hyperplasia / prostate cancer / 誘導体化試薬 / 予後診断 / MSプローブ / エレクトロスプレーイオン化 / 電子捕獲型 / 阻害薬 / マススクリーニング / 誘導体化-LC / ジヒドロテストステロン / テストステロン / バイオマーカー / 前立腺肥大症 / Stress / Guaiacol estrogen / Classical estrogen / Oxosteroid / Neurosteroid / Brain / 増加 / ストレス / グアヤコールエストロゲン / クラシカルエストロゲン / オキソステロイド / ステロイドホルモン / 脳 / kit / radioreceptor assay / immunoaffinity chromatography / monoclonal antibody / polyclonal antidody / [C-11 alpha] hapten / osteoporosis / active form of vitamin D_3 / HPLC / イムノアフィニティークロマト / 特異抗体 / D代謝物 / キット化 / イムノアフィニティクロマトグラフィー / 前処理 / 血中濃度 / 活性型ビタミンD_3 / キツト化 / ラジオレセプターアッセイ / イムノアフィニティクマトグラフィー / モノクローナル抗体 / ポリクローナル抗体 / [C-11 α]ハプテン / 骨粗しょう症 / 活性化ビタミンD_3 / cDNA microarray / 微小環境 / ｱﾝﾄﾞﾛｹﾞﾝ / 共培養 / フラボノイド / SPARC / SOD3 / ミエロペルオキシダーゼ / 好中球 / オゾン酸化 / 分析科学 / 栄養学 / 炎症 / 脂質 / 生活習慣病 / コレステロール / TGFβ / パクリタキセル耐性 / CTEN / トラニラスト / DHEA Less

Development of derivatization method for producing analyte skeleton-containing product ion during MS/MS and its application to specific determination of low-molecular-weight diagnostic markersPrincipal Investigator
- Principal Investigator
  
  東達也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Tokyo University of Science
Development of enhanced throughput LC/MS assays of steroid hormones based on sample and analyte-multiplexingPrincipal Investigator
- Principal Investigator
  
  Higashi Tatsuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Tokyo University of Science
臨床検査応用を目指したLC-MS/MS定量測定法の開発と基盤技術の構築
- Principal Investigator
  
  佐藤守
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Chiba University
Development of derivatization procedures using reagent analogues and isotopologues for enhancing throughput of mass spectrometry-based clinical examinationsPrincipal Investigator
- Principal Investigator
  
  Higashi Tatsuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo University of Science
Development of the quantitative measurement methods by LC-MS/MS for clinical laboratory applications.
- Principal Investigator
  
  Satoh Mamoru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Chiba University
Development of LC-MS/MS-based accurate quantification methods for assessing serum vitamin D metabolites
- Principal Investigator
  
  ISHIGE Takayuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Laboratory medicine
- Research Institution
  Chiba University
Analysis of new-generation neurosteroids in brain by LC/MS/MS coupled to derivatization with ESI-enhancing and deuterium-labeling reagentsPrincipal Investigator
- Principal Investigator
  
  HIGASHI TATSUYA
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo University of Science
Solution of the molecular mechanism about proliferation / recurrence of the prostate cancer and the architecture of the comprehensive treatment strategy for he prostate cancer
- Principal Investigator
  
  NAMIKI Mikio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Development of multi-point recognizing derivatization procedures for reliable diagnoses of inborn errors of metabolismPrincipal Investigator
- Principal Investigator
  
  HIGASHI Tatsuya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo University of Science
Elucidations of the mechanisms for the formation of cholesterol-ozonolysis products in inflamed tissues, their biological activities and involvement in disease development
- Principal Investigator
  
  OHSHIMA Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  University of Shizuoka
The basic research for elucidation of molecular mechanism of the prostate cancer recurrence and the treatment strategy construction
- Principal Investigator
  
  NAMIKI Mikio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Development and application of determination methods of salivary hormones for noninvasive diagnosis of endocrine disordersPrincipal Investigator
- Principal Investigator
  
  HIGASHI Tatsuya
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kanazawa University
Trace charactethation of neurosteroids to develop a new antipsychotic agent targeting neurosteroidogenesisPrincipal Investigator
- Principal Investigator
  
  HIGASHI Tatsuya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kanazawa University
Development of bio-marker for diagnosing prostate cancer and its application
- Principal Investigator
  
  SHIMADA Kazutake
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kanazawa University
Analysis of C-3 epimerization mechanism in vitamin D_3 to develop a new osteoporosis drugPrincipal Investigator
- Principal Investigator
  
  HIGASHI Tatsuya
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kanazawa University
Analysis of Neurosteroids and Its Application to Development of Anti-dementia Medicine
- Principal Investigator
  
  SHIMADA Kazutake
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kanazawa University
Development of Diagnostic Reagent for Osteoporosis with Guidance of Vitamin D Metabolites
- Principal Investigator
  
  SHIMADA Kazutake
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kanazawa University

[Journal Article] Derivatization procedure of estradiol with a combination of MPDNP-F and 4-dimethylaminopyridine to generate product ion containing estradiol-skeleton for reliable determination of its serum/plasma concentrations by LC/ESI-MS/MS2024
- Author(s)
  Kaneko Honoka, Matsuoka Hiroki, Ishige Takayuki, Kobayashi Hironori, Higashi Tatsuya
- Journal Title
  
  Analytical and Bioanalytical Chemistry
  
  Volume: 416 Issue: 2 Pages: 597-608
- DOI
  10.1007/s00216-023-05069-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06070
[Journal Article] Application of 4-Diethylaminobenzoic Acid <i>N</i>-Succinimidyl Ester and Its Deuterated Isotopologue as Derivatization Reagents to Quantitative Analysis of γ-Aminobutyric Acid in Serum by LC/ESI-MS/MS2022
- Author(s)
  Mikami Yohei, Aizawa Mizuo, TodaA Ryoko, Ogawa Shoujiro, Nishimoto-Kusunose Shoichi, Ishige Takayuki, Higashi Tatsuya
- Journal Title
  
  CHROMATOGRAPHY
  
  Volume: 43 Issue: 2 Pages: 53-58
- DOI
  10.15583/jpchrom.2022.004
- ISSN
  1342-8284, 1348-3315
- Year and Date
  2022-06-20
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06990
[Journal Article] A method for determination of aldosterone concentrations of six adrenal venous serum samples during a single LC/ESI-MS/MS run using a sextet of Girard reagents2022
- Author(s)
  Ohta Arisa, Hobo Wataru, Ogawa Shoujiro, Sugiura Yuki, Nishikawa Tetsuo, Nishimoto Koshiro, Nishimoto-Kusunose Shoichi, Higashi Tatsuya
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis
  
  Volume: 207 Pages: 114423-114423
- DOI
  10.1016/j.jpba.2021.114423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06990
[Journal Article] An LC/ESI-MS/MS Method for Quantification of Hexanoylglycine in Three Different Urine Samples Within a Single Run Using Triplex 1-[(4- Diethylaminophenyl)carbonyl]piperazine Isotopologues2022
- Author(s)
  Hobo Wataru, Jo Akihiro, Koyagi Sae, Ogawa Shoujiro, Nishimoto-Kusunose Shoichi, Higashi Tatsuya
- Journal Title
  
  CHROMATOGRAPHY
  
  Volume: 43 Issue: 3 Pages: 111-117
- DOI
  10.15583/jpchrom.2022.010
- ISSN
  1342-8284, 1348-3315
- Year and Date
  2022-10-20
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06990
[Journal Article] An LC/MS/MS Method for Quantifying Testosterone and Dehydroepiandrosterone Sulfate in Four Different Serum Samples during a Single Run2021
- Author(s)
  Fujimura Shunsuke, Ito Takenori, Ogawa Shoujiro, Ishige Takayuki, Nishimoto-Kusunose Shoichi, Higashi Tatsuya
- Journal Title
  
  Anal. Sci.
  
  Volume: advpub Issue: 0 Pages: 167-173
- DOI
  10.2116/analsci.21P268
- NAID
  130008095460
- ISSN
  0910-6340, 1348-2246
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06990, KAKENHI-PROJECT-20K16513
[Journal Article] Derivatization‐based quadruplex LC/ESI?MS/MS method for high throughput quantification of serum dehydroepiandrosterone sulfate2020
- Author(s)
  Aso Saki、Ogawa Shoujiro、Nishimoto‐Kusunose Shoichi、Satoh Mamoru、Ishige Takayuki、Nomura Fumio、Higashi Tatsuya
- Journal Title
  
  Biomedical Chromatography
  
  Volume: 35 Issue: 4
- DOI
  10.1002/bmc.5027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16513, KAKENHI-PROJECT-20K06990, KAKENHI-PROJECT-21K06506
[Journal Article] Quantitative MALDI-MS/MS assay for serum cortisol through charged derivatization2020
- Author(s)
  Nakamura Masahiro、Moritsuna Marina、Yuda Keita、Fujimura Shunsuke、Sugiura Yuki、Shimma Shuichi、Nishimoto Koshiro、Nishikawa Tetsuo、Suematsu Makoto、Ogawa Shoujiro、Higashi Tatsuya
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis
  
  Volume: 178 Pages: 112912-112912
- DOI
  10.1016/j.jpba.2019.112912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06145, KAKENHI-PROJECT-17K08250, KAKENHI-PROJECT-17K15435, KAKENHI-PROJECT-18K09205
[Journal Article] Enhancing LC/ESI-MS/MS Throughput for Plasma Bile Acid Assay by Derivatization-based Sample-Multiplexing2020
- Author(s)
  Jo Akihiro，Koyagi Sae，Hobo Wataru，Otani Saori，Ogawa Shoujiro，Higashi Tatsuya
- Journal Title
  
  Anal. Sci.
  
  Volume: 36 Issue: 9 Pages: 1099-1104
- DOI
  10.2116/analsci.20P082
- NAID
  130007898806
- ISSN
  0910-6340, 1348-2246
- Year and Date
  2020-09-10
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06990
[Journal Article] Derivatization-based sample-multiplexing for enhancing throughput in liquid chromatography/tandem mass spectrometry quantification of metabolites: an overview2020
- Author(s)
  Higashi Tatsuya，Ogawa Shoujiro
- Journal Title
  
  Journal of Chromatography A
  
  Volume: 1634 Pages: 461679-461679
- DOI
  10.1016/j.chroma.2020.461679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06990
[Journal Article] Sample-multiplexing by derivatization using multiple analogous reagents for enhancing throughput in LC/ESI-MS/MS assay of steroids: Plasma 17α-hydroxyprogesterone as an example2020
- Author(s)
  Kamemura Miki，Yokota Mai，Ogawa Shoujiro，Sugiura Takahiro，Higashi Tatsuya
- Journal Title
  
  Journal of Chromatography B
  
  Volume: 1146 Pages: 122117-122117
- DOI
  10.1016/j.jchromb.2020.122117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06990
[Journal Article] (S)-1-(1-Methylpyridin-2-yl)-3-aminopiperidine as a novel derivatization reagent capable of enantiomeric separation and enhanced ESI-MS/MS detection for chiral carboxylic acids2019
- Author(s)
  Matsumoto Takaaki，Sato Maho，Yamazaki Wataru，Ogawa Shoujiro，Higashi Tatsuya
- Journal Title
  
  Microchemical Journal
  
  Volume: 146 Pages: 25-33
- DOI
  10.1016/j.microc.2018.12.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08250
[Journal Article] Identification of conjugation positions of urinary glucuronidated vitamin D 3 metabolites by LC/ESI‐MS/MS after conversion to MS/MS‐fragmentable derivatives2019
- Author(s)
  Yoshimura Yusuke、Hibi Ryuichiro、Nakata Akiho、Togashi Moeka、Ogawa Shoujiro、Ishige Takayuki、Satoh Mamoru、Nomura Fumio、Higashi Tatsuya
- Journal Title
  
  Biomedical Chromatography
  
  Volume: - Issue: 7
- DOI
  10.1002/bmc.4538
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15768, KAKENHI-PROJECT-17K08250, KAKENHI-PROJECT-17KT0124, KAKENHI-PROJECT-18K07462, KAKENHI-PROJECT-17K15435
[Journal Article] A Method for Quantification of Tetrahydroglucocorticoid Glucuronides in Human Urine by LC/MS/MS with Isotope-coded Derivatization2018
- Author(s)
  Matsumoto Takaaki, Yamazaki Wataru, Jo Akihiro, Ogawa Shoujiro, Mitamura Kuniko, Ikegawa Shigeo, Higashi Tatsuya
- Journal Title
  
  Anal. Sci.
  
  Volume: 34 Issue: 9 Pages: 1003-1009
- DOI
  10.2116/analsci.18SCP02
- NAID
  130007474713
- ISSN
  0910-6340, 1348-2246
- Year and Date
  2018-09-10
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08250
[Journal Article] A method for determination of aldosterone in adrenal tributary venous serum by derivatization using Girard P reagent isotopologues followed by LC/ESI-MS/MS2018
- Author(s)
  Higashi Tatsuya, Akaishi Miho, Yokota Mai, Suzuki Tatsunori, Ogawa Shoujiro, Sugiura Yuki, Nishikawa Tetsuo, Nishimoto Koshiro, Suematsu Makoto
- Journal Title
  
  Journal of Chromatography B
  
  Volume: 1092 Pages: 106-113
- DOI
  10.1016/j.jchromb.2018.06.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08250, KAKENHI-PROJECT-18K09205, KAKENHI-PROJECT-15K10650
[Journal Article] Aldosterone and 18-oxocortisol coaccumulation in aldosterone-producing lesions2018
- Author(s)
  Sugiura Yuki, Takeo Emi, Shimma Shuichi, Yokota Mai, Higashi Tatsuya, Seki Tsugio, Mizuno Yosuke, Oya Mototsugu Kosaka Takeo, Omura Masao, Nishikawa Tetsuo, Suematsu Makoto, Nishimoto Koshiro
- Journal Title
  
  Hypertension
  
  Volume: 72 Issue: 6 Pages: 1345-1354
- DOI
  10.1161/hypertensionaha.118.11243
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08250, KAKENHI-PROJECT-18K09205, KAKENHI-PROJECT-16H06145, KAKENHI-PROJECT-18J20250, KAKENHI-PROJECT-15K10650
[Journal Article] Isotope-coded derivatization based LC/ESI-MS/MS methods using a pair of novel reagents for quantification of hydroxycinnamic acids and hydroxybenzoic acids in fermented brown rice product2017
- Author(s)
  Ogawa Shoujiro, Takafuji Kiriko, Tsubuku Sumi, Horie Yukiko, Ikegawa Shigeo, Higashi Tatsuya
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis
  
  Volume: 142 Pages: 162-170
- DOI
  10.1016/j.jpba.2017.04.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08250, KAKENHI-PROJECT-17K15435
[Journal Article] Improved sensitivity of serum/plasma 1α,25-dihydroxyvitamin D quantification by DAPTAD derivatization2017
- Author(s)
  Ishige Takayuki, Satoh Mamoru, Ogawa Shoujiro, Nishimura Motoi, Matsushita Kazuyuki, Higashi Tatsuya, Nomura Fumio
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 473 Pages: 173-179
- DOI
  10.1016/j.cca.2017.08.033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08250, KAKENHI-PROJECT-17K09004, KAKENHI-PROJECT-17KT0124, KAKENHI-PROJECT-17K15435, KAKENHI-PROJECT-17K15768, KAKENHI-PROJECT-15K08610, KAKENHI-PROJECT-15K08611
[Journal Article] Enhancing analysis throughput, sensitivity and specificity in LC/ESI-MS/MS assay of plasma 25-hydroxyvitamin D3 by derivatization with triplex DAPTAD isotopologues2017
- Author(s)
  S. Ogawa, H. Kittaka, A. Nakata, M. Satoh, F. Nomura, T. Higashi
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis
  
  Volume: 136 Pages: 126-133
- DOI
  10.1016/j.jpba.2016.11.030
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460043, KAKENHI-PROJECT-26460505, KAKENHI-PROJECT-15K08610, KAKENHI-PROJECT-17K08250
[Journal Article] Application of Cookson-type reagents for biomedical HPLC and LC/MS analyses: a brief overview2017
- Author(s)
  T. Higashi, K. Shimada
- Journal Title
  
  Biomedical Chromatography
  
  Volume: 31 Issue: 1
- DOI
  10.1002/bmc.3808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460043
[Journal Article] Unconjugated bile acids in rat brain: Analytical method based on LC/ESI-MS/MS with chemical derivatization and estimation of their origin by comparison to serum levels2017
- Author(s)
  Higashi Tatsuya, Watanabe Shui, Tomaru Koki, Yamazaki Wataru, Yoshizawa Kazumi, Ogawa Shoujiro, Nagao Hidenori, Minato Kouichi, Maekawa Masamitsu, Mano Nariyasu
- Journal Title
  
  Steroids
  
  Volume: 125 Pages: 107-113
- DOI
  10.1016/j.steroids.2017.07.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08250
[Journal Article] Development and validation of the simultaneous measurement of four vitamin D metabolites in serum by LC-MS/MS for clinical laboratory applications2016
- Author(s)
  Mamoru Satoh, Takayuki Ishige, Shoujiro Ogawa, Motoi Nishimura, Kazuyuki Matsushita, Tatsuya Higashi, Fumio Nomura
- Journal Title
  
  Anal Bioanal Chem
  
  Volume: 408 Issue: 27 Pages: 7617-7627
- DOI
  10.1007/s00216-016-9821-4
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H06096, KAKENHI-PROJECT-26460043, KAKENHI-PROJECT-26460505, KAKENHI-PROJECT-26460667, KAKENHI-PROJECT-15K08610, KAKENHI-PROJECT-15K08611
[Journal Article] Isotope-coded ESI-enhancing derivatization reagents for differential analysis, quantification and profiling of metabolites in biological samples by LC/MS: a review2016
- Author(s)
  T. Higashi, S. Ogawa
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis
  
  Volume: 130 Pages: 181-193
- DOI
  10.1016/j.jpba.2016.04.033
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460043
[Journal Article] Methods for differential and quantitative analyses of brain neurosteroid levels by LC/MS/MS with ESI-enhancing and isotope-coded derivatization2016
- Author(s)
  T. Higashi, N. Aiba, T. Tanaka, K. Yoshizawa, S. Ogawa
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis
  
  Volume: 117 Pages: 155-162
- DOI
  10.1016/j.jpba.2015.08.040
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460043, KAKENHI-PROJECT-26860027
[Journal Article] A Method for Simultaneous Determination of 25-Hydroxyvitamin D<sub>3</sub> and Its 3-Sulfate in Newborn Plasma by LC/ESI-MS/MS after Derivatization with a Proton-Affinitive Cookson-Type Reagent2016
- Author(s)
  T. Higashi, M. Yokota, A. Goto, S. Ogawa, K. Komatsu, T. Sugiura, M. Satoｈ, F. Nomura
- Journal Title
  
  Mass Spectrometry
  
  Volume: 5 Issue: 2 Pages: S0051-S0051
- DOI
  10.5702/massspectrometry.S0051
- NAID
  130005263499
- ISSN
  2186-5116, 2187-137X
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460043, KAKENHI-PROJECT-26460505, KAKENHI-PROJECT-15K08610
[Journal Article] Methods for determination of fingernail steroids by LC/MS/MS and differences in their contents between right and left hands2016
- Author(s)
  T. Higashi, K. Yamagata, Y. Kato, Y. Ogawa, K. Takano, Y. Nakaaze, T. Iriyama, J. Z. Min, S. Ogawa
- Journal Title
  
  Steroids
  
  Volume: 109 Pages: 60-65
- DOI
  10.1016/j.steroids.2016.02.013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460043, KAKENHI-PROJECT-26860027, KAKENHI-PROJECT-26713021
[Journal Article] Comparative evaluation of new Cookson-type reagents for LC/ESI-MS/MS assay of 25-hydroxyvitamin D3 in neonatal blood samples2016
- Author(s)
  S. Ogawa, H. Kittaka, K. Shinoda, S. Ooki, A. Nakata, T. Higashi
- Journal Title
  
  Biomedical Chromatography
  
  Volume: 30 Issue: 6 Pages: 938-945
- DOI
  10.1002/bmc.3633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460043
[Journal Article] Chemical derivatization for enhancing sensitivity during LC/ESI-MS/MS quantification of steroids in biological samples: a review2016
- Author(s)
  T. Higashi, S. Ogawa
- Journal Title
  
  Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 162 Pages: 57-69
- DOI
  10.1016/j.jsbmb.2015.10.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460043
[Journal Article] Assessment of Vitamin D Metabolism by LC-MS/MS2015
- Author(s)
  Ishige T, Satoh M, Ogawa S, Nishimura M, Higashi T, Nomura F.
- Journal Title
  
  Rinsho Byori
  
  Volume: 63 Pages: 457-464
- NAID
  40020474101
- Data Source
  KAKENHI-PROJECT-15H06096
[Journal Article] Assessment of Vitamin D Metabolism by LC-MS/MS.2015
- Author(s)
  Ishige T, Satoh M, Ogawa S, Nishimura M, Higashi T, Nomura F.
- Journal Title
  
  Rinsho Byori.
  
  Volume: 63(4) Pages: 457-464
- NAID
  40020474101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08610
[Journal Article] Analysis of urinary vitamin D3 metabolites by liquid chromatography/tandem mass spectrometry with ESI-enhancing and stable isotope-coded derivatization2014
- Author(s)
  S. Ogawa, S. Ooki, K. Shinoda, T. Higashi
- Journal Title
  
  Analytical and Bioanalytical Chemistry
  
  Volume: 406 Issue: 26 Pages: 6647-6654
- DOI
  10.1007/s00216-014-8095-y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460043
[Journal Article] (S)-1-(4-Dimethylaminophenyl- carbonyl)-3-aminopyrrolidine : A derivatization reagent for enantiomeric separation and sensitive detection of chiral carboxylic acids by LC/ESI-MS/MS2013
- Author(s)
  S. Ogawa, H. Tadokoro, M. Sato, T. Hanawa, T. Higashi
- Journal Title
  
  Journal of Chromatography B
  
  Volume: 940 Pages: 7-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590046
[Journal Article] 低分子化合物のソフトイオン化MSにおける検出指向誘導体化2013
- Author(s)
  東達也,小川祥二郎
- Journal Title
  
  ぶんせき
  
  Volume: 2013 Pages: 422-428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590046
[Journal Article] (S)-1-(4-Dimethylaminophenylcarbonyl)-3-aminopyrrolidine: A derivatization reagent for enantiomeric separation and sensitive detection of chiral carboxylic acids by LC/ESI-MS/MS2013
- Author(s)
  S. Ogawa, H. Tadokoro, M. Sato, T. Hanawa, T. Higashi
- Journal Title
  
  Journal of Chromatography B
  
  Volume: 940 Pages: 7-14
- DOI
  10.1016/j.jchromb.2013.09.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590046
[Journal Article] LC/MS/MS of Steroids Having Vicinal Diol as Electrospray-Active Boronates2013
- Author(s)
  T. Higashi, K. Kawasaki, N. Matsumoto, S. Ogawa
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 61 Issue: 3 Pages: 326-332
- DOI
  10.1248/cpb.c12-00979
- NAID
  130003360741
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590046, KAKENHI-PROJECT-23590209
[Journal Article] LC/MS/MS of steroids having vicinal diol as electrospray-active boronates2013
- Author(s)
  T. Higashi, K. Kawasaki, N. Matsumoto, S. Ogawa
- Journal Title
  
  Chemical & Pharmaceutical Bulletin
  
  Volume: 61 Pages: 422-428
- NAID
  130003360741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590046
[Journal Article] A novel Cookson-type reagent for enhancing sensitivity and specificity in assessment of infant vitamin D status using liquid chromatography/tandem mass spectrometry2013
- Author(s)
  S. Ogawa, S. Ooki, M. Morohashi, K. Yamagata, T. Higashi
- Journal Title
  
  Rapid Communication in Mass Spectrometry
  
  Volume: 27 Pages: 2453-2460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590046
[Journal Article] A highly sensitive LC-ESI-MS/MS method for the quantification of cholesterol ozonolysis products secosterol-A and secosterol-B after derivatization with 2-hydrazino-1-methylpyridine2011
- Author(s)
  Tomono S, Miyoshi N, Ito M, Higashi T, Ohshima H
- Journal Title
  
  J. Chromatogr. B
  
  Volume: 879 Issue: 26 Pages: 2802-2802
- DOI
  10.1016/j.jchromb.2011.08.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280, KAKENHI-PROJECT-21680052, KAKENHI-PROJECT-23650486
[Journal Article] Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway.2011
- Author(s)
  Tomono S, Miyoshi N, Shiokawa H, Iwabuchi T, Aratani Y, Higashi T, Nukaya H, Ohshima H.
- Journal Title
  
  J.Lipid Res.
  
  Volume: 52 Pages: 87-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway2011
- Author(s)
  Tomono S, Miyoshi N, Shiokawa H, Iwabuchi T, Aratani Y, Higashi T, Nukaya H, Ohshima H
- Journal Title
  
  J. Lipid Res.
  
  Volume: 52 Issue: 1 Pages: 87-97
- DOI
  10.1194/jlr.m006775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Simple and practical derivatization procedure for enhanced detection of carboxylic acids in liquid chromatography-electrospray ionization-tandem mass spectrometry2010
- Author(s)
  T. Higashi, T. Ichikawa, S. Inagaki, J.Z. Min, T. Fukushima, T. Toyo'oka
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis 52
  
  Pages: 809-818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590034
[Journal Article] Salivary chenodeoxycholic acid and its glycine-conjugate : their determination method using LC-MS/MS and variation of their concentrations with increased saliva flow rate2010
- Author(s)
  T. Higashi, Y. Shibayama, T. Ichikawa, K. Ito, T. Toyo'oka, K. Shimada, K. Mitamura, S. Ikegawa, H. Chiba
- Journal Title
  
  Steroids 75
  
  Pages: 338-345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590034
[Journal Article] Simple and practical derivatization procedure for enhanced detection of carboxylic acids in liquid chromatography-electrospray ionization-tandem mass spectrometry2010
- Author(s)
  T.Higashi, T.Ichikawa, S.Inagaki, J.Z.Min, T.Fukushima, T.Toyo'oka
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis
  
  Volume: 52 Pages: 809-818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590034
[Journal Article] Salivary chenodeoxycholic acid and its glycine-conjugate : their determination method using LC-MS/MS and variation of their concentrations with increased saliva flow rate2010
- Author(s)
  T.Higashi, Y.Shibayama, T.Ichikawa, K.Ito, T.Toyo'oka, K.Shimada, K.Mitamura, S.Ikegawa, H.Chiba
- Journal Title
  
  Steroids
  
  Volume: 75 Pages: 338-345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590034
[Journal Article] Simultaneous determination of salivary testosterone and dehydroepiandrosterone using LC-MS/MS : method development and evaluation of applicability for diagnosis and medication for late-onset hypogonadism2009
- Author(s)
  Y. Shibayama, T. Higashi, K. Shimada, A. Odani, A. Mizokami, H. Konaka, E. Koh, M. Namiki
- Journal Title
  
  Journal of Chromatography B 877
  
  Pages: 2615-2623
- NAID
  10028022490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590034
[Journal Article] Simultaneous determination of salivary testosterone and dehydroepiandrosterone using LC-MS/MS : method development and evaluation of applicability for diagnosis and medication for late-onset hypogonadism2009
- Author(s)
  Y.Shibayama, T.Higashi, K.Shimada, A.Odani, A.Mizokami, H.Konaka, E.Koh, M.Namiki
- Journal Title
  
  Journal of Chromatography B 877
  
  Pages: 2615-2623
- NAID
  10028022490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590034
[Journal Article] Liquid chromatography-tandem mass spectrometric method for determination of salivary 25-hydroxyvitamin D_3 : a noninvasive tool for the assessment of vitamin D status2008
- Author(s)
  T. Higashi, Y. Shibayama, M. Fuji, K. Shimada
- Journal Title
  
  Analytical and Bioanalytical Chemistry 391
  
  Pages: 229-238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590034
[Journal Article] Liquid chromatography-tandem mass spectrometric method for determination ofsalivary 17α-hydroxyprogesterone : A noninvasive tool for evaluating efficacy ofhormone replacement therapy in congenital adrenal hyperplasia2008
- Author(s)
  Y. Shibayama, T. Higashi, K. Shimada, Kashimada, T. Onishi, M. Ono, K. Miyai, S. Mizutani
- Journal Title
  
  Journal of Chromatography B 867
  
  Pages: 49-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590034
[Journal Article] Studies on neurosteroids XXII. Liquid chromatography-tandem mass spectrometric method for profiling rat brain 3-oxo-4-ene-neuroactive steroids2008
- Author(s)
  T. Higashi, A. Nagahama, Y. Mukai, K. Shimada
- Journal Title
  
  Biomedical Chromatography 22
  
  Pages: 34-43
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Studies on neurosteroids XXII. Liquid chromatography-tandem mass spectrometric method for profiling rat brain 3-oxo-4-ene-neuroactive steroids2008
- Author(s)
  T. Higashi, A. Nagahama, Y. Mukai, K. Shimada
- Journal Title
  
  Biomedical Chromatography 22(1)
  
  Pages: 34-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Liquid chromatography-tandem mass spectrometric method for detennination of salivary 25-hydroxyvitamin D_3 : a noninvasive tool for assessment of vitamin D status2008
- Author(s)
  T. Higashi, Y Shibayama, M. Fuji, K. Shimada
- Journal Title
  
  Analytical and Bioanalytical Chemistry 391
  
  Pages: 229-238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590034
[Journal Article] Liquid chromatography.tandem mass spectrometric method for determination of salivary 17 α-hydroxyprogesterone : A noninvasive tool for evaluating efficacy of hormone replacement therapy in congenital adrenal hyperplasia2008
- Author(s)
  Y. Shibayama, T. Higashi, K. Shimada, K. Kashimada, T. Onishi, M. Ono, K. Miyai, S. Mizutani
- Journal Title
  
  Journal of Chromatography B 867
  
  Pages: 49-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590034
[Journal Article] Studies on neurosteroids XXIII. Analysis of tetrahydrocorticosterone isomers in the brain of rat exposed to immobilization using LC-MS2007
- Author(s)
  T. Higashi, H. Yokoi, H. Maekubo, A. Honda, K. Shimada
- Journal Title
  
  Steroids 72(13)
  
  Pages: 865-874
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Alternative procedure for charged derivatization to enhance detection responses of steroids in electrospray ionization-MS2007
- Author(s)
  T. Higashi, T. Nishio, N. Hayashi, K. Shimada
- Journal Title
  
  Chemical & Pharmaceutical Bulletin 55
  
  Pages: 662-665
- NAID
  110006241837
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Studies on neurosteroids XIX.Liquid chromatography-tandem mass spectrometric method for simultaneous determination of 5α-reduced pregnane-type neurosteroids in rat brain and serum2007
- Author(s)
  Tatsuya Higashi, Akihiko Nagahama, Norihiro Otomi, Kazutake Shimada
- Journal Title
  
  Journal of Chromatography B 848・2
  
  Pages: 188-199
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Studies on neurosteroids XXIII. Analysis of tetrahydrocorticosterone isomers in the brain of rat exposed to immobilization using LC-MS2007
- Author(s)
  T. Higashi, H. Yokoi, H. Maekubo, A. Honda, K. Shimada
- Journal Title
  
  Steroids 72
  
  Pages: 865-874
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Development and application of electrospray-active derivatization reagents for hydroxysteroids2007
- Author(s)
  T. Nishio, T. Higashi, A. Funaishi, J. Tanaka, K. Shimada
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis 44
  
  Pages: 786-795
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Studies on neurosteroids XIX. Development and validation of liquid chromatography-tandem mass spectrometric method for determination of 5α-reduced pregnane-type neurosteroids in rat brain and serum2007
- Author(s)
  T. Higashi, A. Nagahama, N. Otomi, K. Shimada
- Journal Title
  
  Journal of Chromatography B 48
  
  Pages: 188-199
- NAID
  10025793632
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Alternative procedure for charged derivatization to enhance detection responses of steroids in electrospray ionization-MS2007
- Author(s)
  T. Higashi, T. Nishio, N. Hayashi, K. Shimada
- Journal Title
  
  Chemical & Pharmaceutical Bulletin 55(4)
  
  Pages: 662-665
- NAID
  110006241837
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Studies on neurosteroids XIX. Development and validation of liquid chromatography-tandem mass spectrometric method for determination of 5α-reduced pregnane-type neurosteroids in rat brain and serum2007
- Author(s)
  T. Higashi, A. Nagahama, N. Otomi, K. Shimada
- Journal Title
  
  Journal of Chromatography B 848(2)
  
  Pages: 188-199
- NAID
  10025793632
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Development and application of electrospray-active derivatization reagents for hydroxysteroids2007
- Author(s)
  T. Nishio, T. Higashi, A. Funaishi, J. Tanaka, K. Shimada
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis 44(3)
  
  Pages: 786-795
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Studies on neurosteroids XXI : An improved liquid chromatography-tandem mass spectrometric method for determination of 5α-androstane-3α,17β-diol in rat brains2007
- Author(s)
  T. Higashi, T. Nishio, H. Yokoi, Y. Ninomiya, K. Shimada
- Journal Title
  
  Analytical Science 23(8)
  
  Pages: 1015-1019
- NAID
  10019747846
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Studies on neurosteroids XXIII.Analysis of tetrahydrocorticosterone isomers in the brain of rat exposed to immobilization using LC-MS2007
- Author(s)
  T. Higashi, H. Yokoi, H. Maekubo, A. Honda, K. Shimada
- Journal Title
  
  Steroids 72
  
  Pages: 865-874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Studies on neurosteroids XXI: An improved liquid chromatography-tandem mass spectrometric method for determination of 5α-androstane-3α,17β-diol in rat brains2007
- Author(s)
  T. Higashi, T. Nishio, H. Yokoi, Y. Ninomiya, K. Shimada
- Journal Title
  
  Analytical Sciences 23
  
  Pages: 1015-1019
- NAID
  10019747846
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Studies on neurosteroids XXI: An improved liquid chromatography-tandem mass spectrometric method for determination of 5α-androstane-3α, 17β-diol in rat brains2007
- Author(s)
  T. Higashi, T. Nishio, H. Yokoi, Y. Ninomiya, K. Shimada
- Journal Title
  
  Analytical Sciences 23
  
  Pages: 1015-1019
- NAID
  10019747846
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Studies on neurosteroids XVIII.LC-MS analysis of changes in rat brain and serum testosterone levels induced by immobilization stress and ethanol administration2006
- Author(s)
  T. Higashi, Y. Ninomiya, N. Iwaki, A. Yamauchi, N. Takayama, K. Shimada
- Journal Title
  
  Steroids 71(7)
  
  Pages: 609-617
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Studies on neurosteroids XVIII. LC-MS analysis of changes in rat brain and serum testosterone levels induced by immobilization stress and ethanol administration2006
- Author(s)
  T. Higashi, Y. Ninomiya, N. Iwaki, A. Yamauchi, N. Takayama, K. Shimada
- Journal Title
  
  Steroids 71
  
  Pages: 609-617
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Studies on neurosteroids XVIII. LC-MS analysis of changes in rat brain and serum testosterone levels induced by immobilization stress and ethanol administration2006
- Author(s)
  Tatsuya Higashi, Yasuaki Ninomiya, Naoko Iwaki, Akinori Yamauchi, Naoki Takayama, Kazutake Shimada
- Journal Title
  
  Steroids 71・7
  
  Pages: 609-617
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Trace determination of steroids causing age-related diseases using LC/MS combined with detection-oriented derivatization2006
- Author(s)
  T. Higashi
- Journal Title
  
  Chemical & Pharmaceutical Bulletin 54
  
  Pages: 1479-1485
- NAID
  110004836466
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Trace determination of steroids causing age-related diseases using LC/MS combined with detection oriented derivatization2006
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Chemical ＆ Pharmaceutical Bulletin 54・11
  
  Pages: 1479-1485
- NAID
  110004836466
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Trace determination of steroids causing age-related diseases using LC/MS combined with detection-oriented derivatization2006
- Author(s)
  T. Higashi
- Journal Title
  
  Chemical & Pharmaceutical Bulk in 54(11)
  
  Pages: 1479-1485
- NAID
  110004836466
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Journal Article] Enzymatic conversion of 3ss-hydroxy-5-ene-steroids and their sulfates to 3-oxo-4-ene-steroids for increasing sensitivity in LC-APCI-MS2005
- Author(s)
  Tatsuya Higashi et al.
- Journal Title
  
  J.Pharm.Biomed.Anal. 39(3-4)
  
  Pages: 718-723
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390011
[Journal Article] Determination of prostatic androgens in 10 mg of tissue using liquid chromatography-tandem mass spectrometry with charged derivatization2005
- Author(s)
  Tatsuya Higashi et al.
- Journal Title
  
  Anal.Bioanal.Chem. 382(4)
  
  Pages: 1035-1043
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390011
[Journal Article] Enzymatic conversion of 3ss-hydroxy-5-ene-steroids and their sulfates to 3-oxo-4-ene-steroids for increasing sensitivity in LC-APCI-MS2005
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  J.Pharm.Biomed.Anal. 39(3-4)
  
  Pages: 718-723
- Data Source
  KAKENHI-PROJECT-15390011
[Journal Article] Determination of prostatic androgens in 10 mg of tissue using liquid chromatography-tandem mass spectrometry with charged derivatization2005
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Anal.Bioanal.Chem. 382(4)
  
  Pages: 1035-1043
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390011
[Journal Article] Determination of prostatic androgens in 10 mg tissue using liquid chromatography-tandem mass spectrometry with charged derivatization2005
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Anal.Bioanal.Chem. 382(4)
  
  Pages: 1035-1043
- Data Source
  KAKENHI-PROJECT-15390011
[Journal Article] Enzymatic conversion of 3β-hydroxy-5-ene-steroids and their sulfates to 3-oxo-4-ene-steroids for increasing sensitivity in LC-APCI-MS2005
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  J.Pharm.Biomed.Anal. 39(3-4)
  
  Pages: 718-723
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390011
[Journal Article] Derivatization of neutral steroids to enhance their detection characteristics in liquid chromatography-mass spectrometry2004
- Author(s)
  Tatsuya Higashi, Kazutake Shimdada
- Journal Title
  
  Anal.Bioanal.Chem. 378(4)
  
  Pages: 875-882
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390011
[Journal Article] 2-Hydrazino-I-methylpyridine : a highly sensitive derivatization reagent for oxostreoids in liquid chromatography-electrospray ionization-mass spectrometry.2004
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  J.Chromatogr.B (In press)
- Data Source
  KAKENHI-PROJECT-15390011
[Journal Article] Analysis of C-3 epimerization in (24R)-24,25-dihydroxyvitamin D_3 catalyzed by hydroxysteroid dehydrogenase2004
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis 36(3)
  
  Pages: 429-436
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572030
[Journal Article] Prostate cancer and metabolic analysis of androgens2004
- Author(s)
  Tatsuya Higashi et al.
- Journal Title
  
  Rinshoukagaku 33(4)
  
  Pages: 177-182
- NAID
  10014070714
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390011
[Journal Article] Analysis of C-3 epimerization in (24R)-24,25-dihydroxyvitamin D_3 catalyzed by hydroxysteroid dehydrogenase2004
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis 36-3
  
  Pages: 429-436
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572030
[Journal Article] High-performance liquid chromatography/electron capture atmospheric pressure chemical ionization-mass spectrometric determination of biologically active steroids2004
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Bunseki Kagaku 53-7
  
  Pages: 645-655
- NAID
  110002905410
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572030
[Journal Article] Derivatization of neutral steroids to enhance their detection charact-eristics in liquid chromatography/mass spectrometry2004
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Anal.Bioanal.Chem. 378(4)
  
  Pages: 875-882
- Data Source
  KAKENHI-PROJECT-15390011
[Journal Article] 2-Hydrazino-1-methylpyridine : a highly sensitive derivatization reagent for oxosteroids in liquid chromatography-electrospray ionization-mass spectrometry2004
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  J.Chromatogr.B 825(2)
  
  Pages: 214-222
- NAID
  10016977958
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390011
[Journal Article] 前立腺癌とアンドロゲンの代謝分析2004
- Author(s)
  東達也
- Journal Title
  
  臨床化学 33(4)
  
  Pages: 177-182
- NAID
  10014070714
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390011
[Journal Article] 2-Hydrazino-1-methyl-pyridine : a highly sensitive derivatization reagent for oxosteroids in liquid chromatography-electrospray ionization-mass spectrometry2004
- Author(s)
  Tatsuya Higashi et al.
- Journal Title
  
  J.Chromtaogr.B 825(2)
  
  Pages: 214-222
- NAID
  10016977958
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390011
[Journal Article] 電子捕獲大気圧化学イオン化を利用する生理活性ステロイドの高速液体クロマトグラフィー/質量分析2004
- Author(s)
  東達也
- Journal Title
  
  分析化学 53(7)
  
  Pages: 645-655
- NAID
  110002905410
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572030
[Journal Article] Derivatization of neutral steroids to enhance their detection characteristics in liquid chromatography-mass spectrometry2004
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Anal.Bioanal.Chem. 378(4)
  
  Pages: 875-882
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390011
[Journal Article] Application of 4-(4-nitrophenyl)-1,2,4-triazoline-3,5-dione to analysis of 25-hydroxyvitamin D_3 in human plasma by liquid chromatography/electron capture atmospheric pressure chemical ionization-mass spectrometry2003
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Analytical Sciences 19-6
  
  Pages: 941-943
- NAID
  80015993364
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572030
[Journal Article] Application of 4-(4-nitrophenyl)-1,2,4-triazoline-3,5-dione to analysis of 25-hydroxyvitamin D_3 in human plasma by liquid chromatography/electron capture atmospheric pressure chemical ionization-mass spectrometry2003
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Analytical Sciences 19(6)
  
  Pages: 941-943
- NAID
  80015993364
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572030
[Journal Article] Electron-capturing derivatization of neutral steroids for increasing sensitivity in liquid chromatography/negative atmospheric pressure chemical ionization-mass spectrometry2002
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Analytical Science 18(12)
  
  Pages: 1301-1307
- NAID
  10011309621
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572030
[Journal Article] Liquid chromatography-mass spectrometric method combined with derivatization for determination of 1α-hydroxyvitamin D_3 in human plasma2002
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Journal of Chromatography B 772-2
  
  Pages: 229-238
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572030
[Journal Article] Electron-capturing derivatization of neutral steroids for increasing sensitivity in liquid chromatography/negative atmospheric pressure chemical ionization-mass spectrometry2002
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Analytical Sciences 18-12
  
  Pages: 1301-1307
- NAID
  10011309621
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572030
[Journal Article] Characterization of urinary metabolites of vitamin D_3 in man under physiological conditions using liquid chromatography-tandem mass spectrometry2002
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Journal of Pharmaceutical and Biomedical. Analysis 29(5)
  
  Pages: 947-955
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572030
[Journal Article] Characterization of urinary metabolites of vitamin D_3 in man under physiological conditions using liquid chromatography-tandem mass spectrometry2002
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis 29-5
  
  Pages: 947-955
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572030
[Journal Article] Liquid chromatography-mass spectrometric method combined with derivatization for determination of 1α-hydroxyvitamin D_3 in human plasma2002
- Author(s)
  Tatsuya Higashi
- Journal Title
  
  Journal of Chromatography B 772(2)
  
  Pages: 229-238
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572030
[Journal Article] Development and validation of stable-isotope dilution liquid chromatography-tandem mass spectrometric method for determination of salivary progesterone
- Author(s)
  T. Higashi, K. Ito, M. Narushima, T. Sugiura, S. Inagaki, J.Z. Min, T. Toyo'oka
- Journal Title
  
  Biomed.Chromatogr. 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590034
[Journal Article] Development and validation of stable-isotope dilution liquid chromatography-tandem mass spectrometric method for determination of salivary progesterone
- Author(s)
  T.Higashi, K.Ito, M.Narushima, T.Sugiura, S.Inagaki, J.Z.Min, T.Toyo'oka
- Journal Title
  
  Biomedical Chromatography
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590034
[Journal Article] Stable isotope-dilution liquid chromatography/tandem mass spectrometric method for determination of thyroxine in saliva
- Author(s)
  T.Higashi, T.Ichikawa, S.Inagaki, J.Z.Min, T.Toyo'oka, C.Shimizu, S.Nagai, H.Chiba, S.Ikegawa
- Journal Title
  
  Journal of Chromatography B
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590034
[Journal Article] Stable isotopedilution liquid chromatography/tandem mass spectrometric method for determination of thyroxine in saliva
- Author(s)
  T. Higashi, T. Ichikawa, C. Shimizu, S. Nagai, S. Inagaki, J.Z. Min, H. Chiba, S. Ikegawa, T. Toyo'oka
- Journal Title
  
  J.Chromatogr.B 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590034
[Patent] DERIVATIZATION METHOD, MASS SPECTROMETRY METHOD, DERIVATIZATION REAGENT, AND DERIVATIZATION REAGENT KIT FOR ESTROGEN2023
- Inventor(s)
  東　達也，滝脇正貴，高橋康司，福沢世傑
- Industrial Property Rights Holder
  学校法人東京理科大学，日本電子株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-23K06070
[Patent] DERIVATIZATION METHOD, MASS SPECTROMETRY METHOD, DERIVATIZATION REAGENT, AND DERIVATIZATION REAGENT KIT FOR ESTROGEN2023
- Inventor(s)
  東　達也，滝脇正貴，高橋康司，福沢世傑
- Industrial Property Rights Holder
  学校法人東京理科大学，日本電子株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-23K06070
[Patent] DERIVATIZATION METHOD, MASS SPECTROMETRY METHOD, DERIVATIZATION REAGENT, AND DERIVATIZATION REAGENT KIT FOR ESTROGEN2023
- Inventor(s)
  東　達也，滝脇正貴，高橋康司，福沢世傑
- Industrial Property Rights Holder
  学校法人東京理科大学，日本電子株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-23K06070
[Patent] Method for derivatizing an s-cis-diene compound, derivatization reagent kit, and method for analyzing an s-cis-diene compound2017
- Inventor(s)
  Higashi Tatusya,Ogawa Shoujiro
- Industrial Property Rights Holder
  Higashi Tatusya,Ogawa Shoujiro
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-17K08250
[Patent] METHOD FOR DERIVATIZING AN S-CIS-DIENE COMPOUND, DERIVATIZATION REAGENT KIT, AND METHOD FOR ANALYZING AN S-CIS-DIENE COMPOUND2017
- Inventor(s)
  Higashi Tatsuya他4名
- Industrial Property Rights Holder
  Higashi Tatsuya他4名
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Acquisition Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17K08250
[Patent] ステロイド性生体内微量物質の測定方法2003
- Inventor(s)
  東達也
- Industrial Property Rights Holder
  帝国臓器製薬
- Filing Date
  2003-02-27
- Acquisition Date
  2005-06-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390011
[Presentation] エストラジオールの骨格由来の特異的プロダクトイオンを生成する誘導体化法とそれを用いた血中エストラジオールのLC/ESI-MS/MS定量法の開発2024
- Author(s)
  松岡大暉，金子穂野香，小林弘典，石毛崇之，東　達也
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06070
[Presentation] ステロイドのLC/ESI-MS/MS用誘導体化試薬の開発2023
- Author(s)
  東　達也
- Organizer
  日本医用マススペクトル学会第8回東部会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06070
[Presentation] LC/ESI-MS/MS によるラット脳内非抱合型胆汁酸の一斉分析法の開発と由来解析2023
- Author(s)
  渋谷斗磨，佐藤安里，楠瀬翔一，東　達也
- Organizer
  第34回クロマトグラフィー科学会議
- Data Source
  KAKENHI-PROJECT-23K06070
[Presentation] エストラジオール骨格を含む特異的プロダクトイオンを生成する誘導体化法とそれを用いた血中エストラジオールの高精度LC/ESI-MS/MS定量法2023
- Author(s)
  金子穂野香，松岡大暉，野津吉友，小林弘典，石毛崇之，東　達也
- Organizer
  第48回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-23K06070
[Presentation] 6種のGirard試薬を用いた副腎静脈血清中アルドステロンの6検体一括LC/ESI-MS/MS定量法の開発2021
- Author(s)
  太田有紗，帆保　航，水元優花，楠瀬翔一，小川祥二郎，杉浦悠毅，西本紘嗣郎，東　達也
- Organizer
  第46回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-20K06990
[Presentation] DEAPPZアイソトポログ誘導体化による尿中hexanoylglycineの3検体一括LC/ESI-MS/MS定量法の開発2021
- Author(s)
  帆保　航，城　彰宏，小八木冴，小川祥二郎，楠瀬翔一，東　達也
- Organizer
  第33回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-20K06990
[Presentation] DEAPPZアイソトポログを用いるhexanoylglycineの尿3検体一括LC/ESI-MS/MS定量法2021
- Author(s)
  帆保　航，城　彰宏，小八木冴，小川祥二郎，楠瀬翔一，東　達也
- Organizer
  第32回クロマトグラフィー科学会議
- Data Source
  KAKENHI-PROJECT-20K06990
[Presentation] Enhancing sensitivity, specificity and analysis throughput for LC/ESI-MS/MS assessment of vitamin D status by derivatization with DAPTAD2021
- Author(s)
  Tatsuya Higashi
- Organizer
  31st International Symposium on Pharmaceutical and Biomedical Analysis (PBA2021)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06990
[Presentation] Girard試薬アナログ及びアイソトポログを用いた血清中DHEASの4検体一括LC/MS/MS定量2020
- Author(s)
  東　達也，麻生早希，小川祥二郎，佐藤　守，石毛崇之，野村文夫
- Organizer
  日本臨床化学会第60回年次学術集会
- Data Source
  KAKENHI-PROJECT-20K06990
[Presentation] 6種のGirard型試薬を用いた副腎静脈血清中アルドステロンの6検体一括LC/ESI-MS/MS定量法の開発2020
- Author(s)
  帆保　航，小八木　冴，太田有紗，楠瀬翔一，小川祥二郎，杉浦悠毅，東　達也
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K06990
[Presentation] 4種のGirard型試薬を用いた血漿中17α-hydroxyprogesteroneの4検体一括LC/ESI-MS/MS定量法2020
- Author(s)
  亀村美樹，小川祥二郎，東　達也
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] 2種のGirard試薬とそれらのアイソトポログを用いる血清中アンドロゲンの4検体一活LC/ESI-MS/MS定量法の開発2020
- Author(s)
  藤村俊輔，伊藤孟徳，小川祥二郎，東　達也
- Organizer
  第31回クロマトグラフィー科学会議
- Data Source
  KAKENHI-PROJECT-20K06990
[Presentation] 新規LC/ESI-MS/MS定量法による3種の麹のエルゴチオネイン含量測定2019
- Author(s)
  堀江裕紀子，後藤綺花，今村梨子，伊藤麻里，池川繁男，小川祥二郎，東　達也
- Organizer
  第71回生物工学会大会
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] Development of LC/ESI-MS/MS method combined with derivatization for determination of L-ergothioneine in Aspergillus oryzae-fermented products of rice and rice bran2019
- Author(s)
  Yukiko Horie, Ayaka Goto, Riko Imamura, Mari Itoh, Shigeo Ikegawa, Shoujiro Ogawa, Tatsuya Higashi
- Organizer
  HPLC Kyoto - The 49th International Symposium on High Performance Liquid Phase Separations and Related Techniques
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] DAPTAD誘導体化：LC/MSによる新生児のビタミンD供給状態評価の質を向上させる2019
- Author(s)
  東　達也
- Organizer
  日本分析化学会中部支部　静岡地区講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] 荷電誘導体化を用いた血清中cortisolのMALDI-MS/MS定量法の開発2019
- Author(s)
  藤村俊輔，森綱茉里奈，中村将大，小川祥二郎，杉浦悠毅，新間秀一，東　達也
- Organizer
  第32回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] 誘導体化－LC/ESI-MS/MSによる麹中エルゴチオネイン定量法の開発2019
- Author(s)
  堀江裕紀子，後藤綺花，今村梨子，伊藤麻里，池川繁男，小川祥二郎，東　達也
- Organizer
  日本分析化学会第68年会
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] MPAPp：光学活性カルボン酸のLC/ESI-MS/MS用荷電誘導体化試薬の開発と評価2019
- Author(s)
  松本孝彬，小川祥二郎，東　達也
- Organizer
  第26回クロマトグラフィーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] 質量分析による主要なビタミンD代謝物の一斉定量への挑戦2019
- Author(s)
  石毛崇之，佐藤　守，小川祥二郎，西村　基，川崎健治，松下一之，東　達也，野村文夫
- Organizer
  日本臨床化学会第59回年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] 化学的手法とLC/ESI-MS/MSを組み合わせた，尿中グルクロン酸抱合型ビタミンD3代謝物の同定2019
- Author(s)
  吉村友佑，冨樫萌香，小川祥二郎，東　達也
- Organizer
  日本臨床化学会第59回年次学術集会
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] MALDI/TOF-MS(/MS)によるステロイド定量法の開発2018
- Author(s)
  中村将大，森綱茉里奈，湯田啓太，堀江裕紀子，小川祥二郎，杉浦悠毅，東　達也
- Organizer
  第31回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] 4種のGirard試薬アナログを用いた誘導体化によるステロイドのハイスループットLC/ESI-MS/MS定量法の開発2018
- Author(s)
  亀村美樹，横田麻衣，小川祥二郎，東　達也
- Organizer
  第43回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] DAPPZアイソトポログ誘導体化による胆汁酸のハイスループットLC/ESI-MS/MS定量法の開発2018
- Author(s)
  城　彰宏，大谷沙織，小川祥二郎，東　達也
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] Girard試薬Pアイソトポログを用いた副腎静脈血清中アルドステロンのLC/ESI-MS/MS定量法2018
- Author(s)
  赤石美帆，横田麻衣，小川祥二郎，杉浦悠毅，西川哲男，西本紘嗣郎，東　達也
- Organizer
  第43回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] LC/MS/MSによる血清/血漿1α,25-ジヒドロキシビタミンD定量および分析前変動要因の評価2018
- Author(s)
  石毛崇之，佐藤　守，小川祥二郎，西村　基，松下一之，東　達也，野村文夫
- Organizer
  第43回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] DAPPZアイソトポログを用いる血漿中胆汁酸の3検体一括LC/ESI-MS/MS定量法の開発2018
- Author(s)
  城　彰宏，大谷彩織，小川祥二郎，東　達也
- Organizer
  第29回クロマトグラフィー科学会議
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] Girard 試薬アナログを用いるステロイドのハイスループットLC/ESI-MS/MS定量法の開発2018
- Author(s)
  亀村美樹，横田麻衣，小川祥二郎，東　達也
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] 光学活性カルボン酸のLC/ESI-MS/MS用新規荷電誘導体化試薬の開発2017
- Author(s)
  松本孝彬，山崎　航，戸田量子，小川祥二郎，東　達也
- Organizer
  第30回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] ICD-LC/ESI-MS/MSによる尿中テトラヒドロコルチコステロイドグルクロニドの定量法の開発2017
- Author(s)
  松本孝彬，山崎　航，小川祥二郎，三田村邦子，池川繁男，東　達也
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] DAPTAD誘導体化－LC/ESI-MS/MSによる尿中グルクロン酸抱合型ビタミンD3代謝物の分析2017
- Author(s)
  小川祥二郎，中田彬穂，日比隆一郎，吉村友佑，橘高宏貴，東　達也
- Organizer
  第30回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] Girard P試薬アイソトポログを用いるsAVS試料中アルドステロンのLC/ESI-MS/MS定量2017
- Author(s)
  赤石美帆，横田麻衣，杉浦悠毅，西本紘嗣郎，小川祥二郎，東　達也
- Organizer
  第24回クロマトグラフィーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] MALDI/TOF-MS(/MS)による血漿中DHEAS及びコルチゾール定量の試み2017
- Author(s)
  中村将大，湯田啓太，小川祥二郎，杉浦悠毅，新間秀一，東　達也
- Organizer
  第42回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] 誘導体化LC/ESI-MS/MSを用いるコレステロール代謝物の網羅的分析系の構築2017
- Author(s)
  河俣圭太，前川正充，三枝大輔，小川祥二郎，東　達也，山口浩明，眞野成康
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] 誘導体化試薬アイソトポログを利用する低分子化合物のLC/ESI-MS/MS定量2017
- Author(s)
  東　達也
- Organizer
  第24回クロマトグラフィーシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] 誘導体化LC/ESI-MS/MSを用いるコレステロール代謝物の網羅的分析法の検討2017
- Author(s)
  前川正充，河俣圭太，三枝大輔，小川祥二郎，東　達也，山口浩明，眞野成康
- Organizer
  第28回日本臨床化学会東北支部総会
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] 誘導体化－LC/ESI-MS/MSによる尿中グルクロン酸抱合型ビタミンD3代謝物の同定及び定量2017
- Author(s)
  小川祥二郎，中田彬穂，日比隆一郎，吉村友佑，橘高宏貴，東　達也
- Organizer
  第42回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] 誘導体化LC/ESI-MS/MSによるコレステロール代謝物の網羅的分析法に関する基礎的検討2017
- Author(s)
  前川正充，河俣圭太，三枝大輔，小川祥二郎，東　達也，山口浩明，眞野成康
- Organizer
  第28回クロマトグラフィー科学会議
- Data Source
  KAKENHI-PROJECT-17K08250
[Presentation] 種々のCookson型試薬による7-dehydrocholesterol誘導体のプロトン親和力とESI-MS感度との関係2017
- Author(s)
  小川祥二郎，渡部ひとみ，茶谷　仁，島田洋輔，坪郷　哲，後藤　了，東　達也
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] DAPTADアイソトポログを用いた血漿中25-hydroxyvitamin D3の高感度・ハイスループットLC/ESI-MS/MS分析法の開発2016
- Author(s)
  橘高宏貴，中田彬穂，小川祥二郎，東　達也
- Organizer
  第29回バイオメディカル分析科学シンポジウム
- Place of Presentation
  京都大学桂キャンパス（京都府）
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] Development and validation of simultaneous measurements of four vitamin D metabolites in serum by LC-MS/MS for Clinical laboratory2016
- Author(s)
  Satoh M, Ishige T, Ogawa S, Nishimura M, Matsushita K, Higashi T, Nomura F.
- Organizer
  The Official 68th AACC Annual Scientific Meeting & Clinical Lab Expo
- Place of Presentation
  Philadelphia（アメリカ）
- Year and Date
  2016-07-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08610
[Presentation] Cookson型誘導体化試薬のESI-MS/MS分析における感度向上能と量子計算に基づくプロトン親和力との関係2016
- Author(s)
  小川祥二郎，渡部ひとみ，茶谷　仁，島田洋輔，恒岡弥生，後藤　了，東　達也
- Organizer
  日本分析化学会第65年会
- Place of Presentation
  北海道大学工学部（北海道）
- Year and Date
  2016-09-16
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] 誘導体化－LC/ESI-MS/MSによる新生児ビタミンD欠乏症の精密診断法の開発2016
- Author(s)
  東　達也
- Organizer
  第64回質量分析総合討論会
- Place of Presentation
  ホテル阪急エキスポパーク（大阪府）
- Year and Date
  2016-05-19
- Invited
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] ESI増強誘導体化試薬を用いるラット脳内胆汁酸のLC/MS/MS定量2016
- Author(s)
  小川祥二郎, 都丸晃輝, 渡辺趣衣, 眞野成康，東　達也
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] 非侵襲ステロイド検査試料としての爪の有用性2016
- Author(s)
  小川祥二郎，高野　香，中畔勇太郎，閔　俊哲，東　達也
- Organizer
  第29回バイオメディカル分析科学シンポジウム
- Place of Presentation
  京都大学桂キャンパス（京都府）
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] LC/ESI-MS/MSを用いた新生児血漿中25-hydroxyvitamin D3及びその硫酸抱合体の同時定量2016
- Author(s)
  横田麻衣，後藤彩佳，小川祥二郎，小松賢司，杉浦崇浩，東　達也
- Organizer
  日本分析化学会第65年会
- Place of Presentation
  北海道大学工学部（北海道）
- Year and Date
  2016-09-14
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] LC/MS/MS の臨床検査応用 ― ビタミン D 代謝物測定を基盤に ―2015
- Author(s)
  佐藤守, 石毛崇之, 小川祥二郎, 西村基, 松下一之, 東達也, 野村文夫
- Organizer
  JHUPO 第13回大会
- Place of Presentation
  くまもと森都心プラザ（熊本県熊本市）
- Year and Date
  2015-07-13
- Data Source
  KAKENHI-PROJECT-15K08610
[Presentation] ESI増強重水素試薬を用いる脳内神経活性ステロイドのレベル変動解析2015
- Author(s)
  相葉尚人, 田中智哉, 大和　遼, 吉澤一巳, 小川祥二郎, 東　達也
- Organizer
  第26回クロマトグラフィー科学会議
- Place of Presentation
  九州大学医系キャンパス　コラボステーション（福岡県）
- Year and Date
  2015-11-11
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] カルボン酸用ESI活性誘導体化試薬の開発と生体試料分析への応用2015
- Author(s)
  都丸晃輝, 小川祥二郎, 渡辺趣衣, 眞野成康，東　達也
- Organizer
  第26回クロマトグラフィー科学会議
- Place of Presentation
  九州大学医系キャンパス　コラボステーション（福岡県）
- Year and Date
  2015-11-11
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] LC/MS/MSの臨床検査応用 - ビタミンD代謝物測定を基盤に -2015
- Author(s)
  佐藤守, 石毛崇之, 小川祥二郎, 西村基, 松下一之, 東達也, 野村文夫
- Organizer
  日本臨床検査自動化学会第47回大会
- Place of Presentation
  パシフィコ横浜 (神奈川県･横浜市)
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15H06096
[Presentation] LC/MS/MSの臨床検査応用 - ビタミンD代謝物測定を基盤に -2015
- Author(s)
  佐藤守, 石毛崇之, 小川祥二郎, 西村基, 松下一之, 東達也, 野村文夫
- Organizer
  第40回日本医用マススペクトル学会年会
- Place of Presentation
  アクトシティ浜松コングレスセンター (静岡県･浜松市)
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-15H06096
[Presentation] ステロイド検査試料としての爪の評価：左右の手の爪中ステロイドの含量差2015
- Author(s)
  小川祥二郎，加藤由那，高野　香，中畔勇太郎，山形憲一郎，閔　俊哲，東　達也
- Organizer
  第40回日本医用マススペクトル学会年会
- Place of Presentation
  アクトシティ浜松（静岡県）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] LC/MS/MSの臨床検査応用 ―ビタミンD代謝物測定を基盤に―2015
- Author(s)
  佐藤守, 石毛崇之, 小川祥二郎, 西村基, 松下一之, 東達也, 野村文夫
- Organizer
  第 40回日本医用マススペクトル学会年会
- Place of Presentation
  アクトシティ浜松　コングレスセンター（静岡県浜松市）
- Year and Date
  2015-09-16
- Data Source
  KAKENHI-PROJECT-15K08610
[Presentation] ESI活性重水素標識試薬を用いるラット脳内神経活性ステロイド分析法の開発2015
- Author(s)
  相葉尚人，田中智哉，小川祥二郎，東　達也
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸サンボーホール（兵庫県）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] カルボン酸用新規ESI増強重水素標識試薬の合成とLCにおける同位体効果の評価2015
- Author(s)
  小川祥二郎，高藤季里子，堀江裕紀子，池川繁男，東　達也
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸サンボーホール（兵庫県）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] ESI増強重水素標識Cookson型試薬を用いる尿中ビタミンD_3代謝物のLC/MS/MS定量法の開発2014
- Author(s)
  小川祥二郎,大木智,篠田健太,東達也
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] 低分子化合物のLC/ESI-MS/MS用誘導体化：検出感度の向上と構造微小差の弁別2014
- Author(s)
  東　達也
- Organizer
  第39回日本医用マススペクトル学会年会
- Place of Presentation
  三井ガーデンホテル千葉（千葉県）
- Year and Date
  2014-10-16
- Invited
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] ESI増強重水素標識試薬を用いた尿中ビタミンD3代謝物のLC/MS/MS分析法の開発2014
- Author(s)
  大木　智，篠田健太，小川祥二郎，東　達也
- Organizer
  第39回日本医用マススペクトル学会年会
- Place of Presentation
  三井ガーデンホテル千葉（千葉県）
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-26460043
[Presentation] プロトン親和性ボロン酸を用いたビシナルジオールステロイドの高感度LC/ESIMS/MS2013
- Author(s)
  川﨑勝己,松本奈宜砂,小川祥二郎,東達也
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] ESI増強誘導体化試薬を用いる低分子化合物の高感度LC/MS/MS2013
- Author(s)
  東達也
- Organizer
  第2回千葉医用マススペクトロメトリー研究会
- Place of Presentation
  千葉
- Year and Date
  2013-12-10
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] 唾液中低分子バイオマーカーのLC/MS/MS2013
- Author(s)
  東達也
- Organizer
  第60回日本臨床検査医学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2013-11-01
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] 光学活性カルボン酸のLC/ESI-MS/MS用新規誘導体化試薬の開発と唾液中NSAIDs分析への応用2013
- Author(s)
  田所弘晃,佐藤真帆,小川祥二郎,東達也
- Organizer
  第24回クロマトグラフィー科学会議
- Place of Presentation
  東京
- Year and Date
  2013-11-12
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] 新規Cookson型試薬の開発と新生児DBS中25-ヒドロキシビタミンD_3測定への応用2013
- Author(s)
  大木智,篠田健太,諸橋美里,小川祥二郎,東達也
- Organizer
  第26回バイオメディカル分析科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2013-08-02
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] 1-DAPAP:光学活性カルボン酸のLC/ESI-MS/MS用新規誘導体化試薬の開発2013
- Author(s)
  田所弘晃,佐藤真帆,小川祥二郎,東達也
- Organizer
  第11回次世代を担う若手のためのフィジカル・ファーマフォーラム
- Place of Presentation
  静岡
- Year and Date
  2013-08-29
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] 誘導体化-LC/ESI-MS/MSによる低分子バイオマーカーのトレースキャラクタリゼーション2012
- Author(s)
  東達也
- Organizer
  第52回日本臨床化学会年次学術集会
- Place of Presentation
  盛岡
- Year and Date
  2012-09-08
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] 微量ステロイドバイオマーカーのLC-ESI/MS/MSにおける環状誘導体化の有用性2012
- Author(s)
  川﨑勝己,松本奈宜砂,小川祥二郎,東達也
- Organizer
  日本分析化学会第61年会
- Place of Presentation
  金沢
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] Secosterol型コレステロール酸化物の生体内生成機構と生理活性2011
- Author(s)
  三好規之、伴野勧、瀬盈伶、東達也、荒谷康昭、大島寛史
- Organizer
  第64回日本酸化ストレス学会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] 同位体希釈LC-ESI-MS/MSによる唾液中チロキシン定量法の開発2010
- Author(s)
  市川拓也, 東達也, 稲垣真輔, 閔俊哲, 豊岡利正
- Organizer
  第21回クロマトグラフィー科学会議
- Place of Presentation
  西宮
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-20590034
[Presentation] 乳がんのリスクマーカーとしての尿中のカテコールエストロゲン-DNA付加体の分析2010
- Author(s)
  戸井口恭子、三好規之、東達也、糠谷東雄、高橋智、若林敬二、大島寛史
- Organizer
  第39回日本環境変異原学会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Liquid chromatography-mass spectrometric assays of salivary hormones and related compounds2010
- Author(s)
  東達也, 島田和武, 豊岡利正
- Organizer
  The 12^<th> Asia-Pacific Congress of Clinical Biochemistry
- Place of Presentation
  Seoul
- Year and Date
  2010-10-05
- Data Source
  KAKENHI-PROJECT-20590034
[Presentation] 臨床・栄養化学上重要なカルボン酸の簡便なLC-ESI-MS/MS用検出指向誘導体化法の開発2010
- Author(s)
  市川拓也, 東達也, 稲垣真輔, 閔俊哲, 福島健, 豊岡利正
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20590034
[Presentation] アセトアルデヒドを消去する食品及び食品成分の探索2010
- Author(s)
  鈴木啓子、三好規之、糠谷東雄、大島寛史
- Organizer
  第54回日本食品科学工学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Secosterol型コレステロール酸化物のLC-MS/MSによる高感度検出法の開発2010
- Author(s)
  三好規之、伊藤萌、伴野勧、東達也、大島寛史
- Organizer
  第63回日本酸化ストレス学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] カルボン酸のESI-MS/MS用検出指向誘導体化法の開発と唾液分析への応用2010
- Author(s)
  市川拓也, 東達也, 稲垣真輔, 閔俊哲, 豊岡利正
- Organizer
  第17回クロマトグラフィーシンポジウム
- Place of Presentation
  広島
- Year and Date
  2010-06-05
- Data Source
  KAKENHI-PROJECT-20590034
[Presentation] Secosterol型コレステロール酸化物のLC-MS/MSによる高感度検出法の開発2010
- Author(s)
  三好規之, 伊藤萌, 伴野勧, 東達也, 大島寛史
- Organizer
  第63回日本酸化ストレス学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] 唾液中アンドロゲンのLC-MS定量法の開発とそれを用いる無侵襲LOH症候群診断の試み2009
- Author(s)
  東達也, 柴山優人, 島田和武, 豊岡利正
- Organizer
  第22回バイオメディカル分析科学シンポジウム
- Place of Presentation
  各務原
- Year and Date
  2009-07-16
- Data Source
  KAKENHI-PROJECT-20590034
[Presentation] 唾液中胆汁酸:LC-ESI-MS/MS定量法と唾液分泌量亢進に伴う濃度変動2009
- Author(s)
  東達也, 柴山優人, 島田和武, 三田村邦子, 池川繁男, 豊岡利正
- Organizer
  第34回日本医用マススペクトル学会年会
- Place of Presentation
  東大阪
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-20590034
[Presentation] LOH症候群の無侵襲診断・治療効果モニタリングを目指した唾液中アンドロゲンのLC-ESI-MS/MSによる定量2009
- Author(s)
  柴山優人, 東達也, 島田和武, 小谷明, 溝上敦, 小中弘之, 高栄哲, 並木幹夫
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-20590034
[Presentation] 唾液中17a-hydroxyprogesteroneのLC-MS/MS定量法の開発とCAHにおける治療効果モニタリングへの適用2008
- Author(s)
  柴山優人, 東達也, 島田和武, 鹿島田健一, 大西寿和
- Organizer
  第21回バイオメディカル分析科学シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2008-08-07
- Data Source
  KAKENHI-PROJECT-20590034
[Presentation] 唾液中17α-hydroxyprogesteroneのLC-MS/MS定量法の開発とCAHにおける治療効果モニタリングへの適用2008
- Author(s)
  柴山優人, 東達也, 島田和武, 鹿島田健一, 大西寿和
- Organizer
  第21回バイオメディカル分析科学シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2008-08-07
- Data Source
  KAKENHI-PROJECT-20590034
[Presentation] LC-ESI-MS/MSによるラット脳内神経活性アンドロゲンの定量2008
- Author(s)
  名倉由希子, 東達也, 横井宏之, 島田和武
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] 唾液を用いる無侵襲ホルモン検査法の開発2008
- Author(s)
  東達也
- Organizer
  第33回日本医用マススペクトル学会年会
- Place of Presentation
  東京
- Year and Date
  2008-09-25
- Data Source
  KAKENHI-PROJECT-20590034
[Presentation] LC-ESI-MSIMSによるラット脳内神経活性アンドロゲンの定量2008
- Author(s)
  名倉由希子, 東達也, 横井宏之, 島田和武
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] Determination of neuroactive androgens in rat brains using LC-ESI-MS/MS2008
- Author(s)
  Y. Nagura, T. Higashi, H. Yokoi, K. Shimada
- Organizer
  128th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Yokohama
- Year and Date
  2008-03-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] LC/電子捕獲APCI-MSによるラット脳内corticosterone代謝物の同定2007
- Author(s)
  横井宏之, 東達也, 島田和武
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] Detection and characterization of corticosterone metabolites in rat brains using LC-electron capture APCI-MS2007
- Author(s)
  H. Yokoi, T. Higashi, K. Shimada
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Toyama
- Year and Date
  2007-03-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] 拘束ストレスによるラット脳内及び血清中testosterone及び5α-dihydrotestosteroneレベルの変動解析2007
- Author(s)
  二ノ宮康昭, 東達也, 島田和武
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] ステロイドのcharged derivatizationを補完するESI-MS用検出指向誘導体化2007
- Author(s)
  西尾忠, 東達也, 林法子, 島田和武
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] LC-MSによるストレス負荷ラット脳内tetrahydrocorticosteroneの同定及び定量2007
- Author(s)
  横井宏之, 東達也, 島田和武
- Organizer
  日本分析化学会第56年会
- Place of Presentation
  徳島
- Year and Date
  2007-09-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] Analysis of stress-induced changes in rat brain neuroactive steroid levels using LC/MS coupled with derivatization2007
- Author(s)
  T. Higashi, A. Nagahama, Y. Ninomiya, K. Shimada
- Organizer
  4th International Meeting on Steroid and Nervous System
- Place of Presentation
  Turin
- Year and Date
  2007-02-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] ピリジル基の導入及びニトロフェニルヒドラゾン形成に基づくステロイドのESI-MS用高感度検出法の開発2007
- Author(s)
  西尾忠, 東達也, 島田和武
- Organizer
  第68回分析化学討論会
- Place of Presentation
  宇都宮
- Year and Date
  2007-05-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] Analysis of stress-induced changes in rat brain neuroactive steroid levels using LC/MS coupled with derivatization2007
- Author(s)
  T. Higashi, A. Nagahama, Y. Ninomiya, K. Shimada
- Organizer
  4th International Meeting on Steroid and Nervous System
- Place of Presentation
  Turin, Italy
- Year and Date
  2007-02-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] Analysis of influence of immobilization stress on rat brain and serum testosterone and 5α-dihydrotestosterone levels2007
- Author(s)
  Y. Ninomiya, T. Higashi, K. Shimada
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Toyama
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] Alternative procedure for charged derivatization to enhance detection responses of steroids in ESI-MS2007
- Author(s)
  T. Nishio, I. Higashi, N. Hayashi, K. Shimada
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Toyama
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] Characterization and determination of tetrahydrocorticosterone isomers in brain of rats exposed to immobilization using LC-MS2007
- Author(s)
  H. Yokoi, T. Higashi, K. Shimada
- Organizer
  56th Annual Meeting of the Japan Society for Analytical Chemistry
- Place of Presentation
  Tokushima
- Year and Date
  2007-09-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] Procedures for increasing detection responses of steroids in ESI-MS based on introduction of pyridyl group and formation of nitrophenylhydrazone2007
- Author(s)
  T. Nishio, T. Higashi, K. Shimada
- Organizer
  68th Symposium on Analytical Chemistry
- Place of Presentation
  Utsunomiya
- Year and Date
  2007-05-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] ステロイドの水酸基を標的としたLC/ESI-MS用誘導体化試薬の開発2006
- Author(s)
  西尾忠, 田中淳, 東達也, 島田和武
- Organizer
  第63回北陸質量分析談話会
- Place of Presentation
  金沢
- Year and Date
  2006-11-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] LC/MSによるGABA作動性神経活性ステロイドの定量法の開発2006
- Author(s)
  長濱彰宏, 東達也, 島田和武
- Organizer
  第19回バイオメディカル分析科学シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2006-08-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] Development of highly sensitive derivatization reagents for hydroxy group of steroids in LC/ESI-MS2006
- Author(s)
  T. Nishio, T. Higashi, K. Shimada
- Organizer
  19th Symposium of Biomedical-Analytical Sciences
- Place of Presentation
  Fukuoka
- Year and Date
  2006-08-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] Development of derivatization reagents to enhance detection responses of hydroxysteroids in LC/ESI-MS2006
- Author(s)
  T. Nishio, J. Tanaka, T. Higashi, K. Shimada
- Organizer
  63th Hokuriku-Area Colloquium on Mass Spectrometry
- Place of Presentation
  Kanazawa
- Year and Date
  2006-11-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] Determination of 5α-reduced pregnane-type neurosactive steroids in rat brains and serum using LC/MS/MS2006
- Author(s)
  A. Nagahama, T. Higashi, K. Shimada
- Organizer
  115th Meeting of Hokuriu Branch of the Pharmaceutical Society of Japan
- Place of Presentation
  Toyama
- Year and Date
  2006-11-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] LC/MS/MSによるラット脳内及び血清中5α-還元型プレグナン神経活性ステロイドの定量2006
- Author(s)
  長濱彰宏, 東達也, 島田和武
- Organizer
  日本薬学会北陸支部第115回例会
- Place of Presentation
  富山
- Year and Date
  2006-11-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] ステロイドの水酸基をターゲットとしたLC/ESI-MS用高感度誘導体化試薬の開発2006
- Author(s)
  西尾忠, 東達也, 島田和武
- Organizer
  第19回バイオメディカル分析科学シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2006-08-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] Simultaneous determination of GABAergic neuroactive steroids in rat brain and serum using LC/MS2006
- Author(s)
  A. Nagahama, T. Higashi, K. Shimada
- Organizer
  19th Symposium of Biomedical-Analytical Sciences
- Place of Presentation
  Fukuoka
- Year and Date
  2006-08-02
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590031
[Presentation] 新規Cookson型試薬の開発と新生児DBS中25-ヒドロキシビタミンD3測定への応用
- Author(s)
  大木　智，篠田健太，諸橋美里，小川祥二郎，東　達也
- Organizer
  第26回バイオメディカル分析科学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] 光学活性カルボン酸のLC/ESI-MS/MS用新規誘導体化試薬の開発と唾液中NSAIDs分析への応用
- Author(s)
  田所弘晃，佐藤真帆，小川祥二郎，東　達也
- Organizer
  第24回クロマトグラフィー科学会議
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] 微量ステロイドバイオマーカーのLC-ESI/MS/MSにおける環状誘導体化の有用性
- Author(s)
  川崎勝己，松本奈宜砂，小川祥二郎，東　達也
- Organizer
  日本分析化学会第61年会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] 1-DAPAP：光学活性カルボン酸のLC/ESI-MS/MS用新規誘導体化試薬の開発
- Author(s)
  田所弘晃，佐藤真帆，小川祥二郎，東　達也
- Organizer
  第11回次世代を担う若手のためのフィジカル・ファーマフォーラム
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] プロトン親和性ボロン酸を用いたビシナルジオールステロイドの高感度LC/ESIMS/MS
- Author(s)
  川崎勝己，松本奈宜砂，小川祥二郎，東　達也
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] ESI増強誘導体化試薬を用いる低分子化合物の高感度LC/MS/MS
- Author(s)
  東　達也
- Organizer
  第2回千葉医用マススペクトロメトリー研究会
- Place of Presentation
  千葉
- Invited
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] 誘導体化－LC/ESI-MS/MSによる低分子バイオマーカーのトレースキャラクタリゼーション
- Author(s)
  東　達也
- Organizer
  第52回日本臨床化学会年次学術集会
- Place of Presentation
  盛岡
- Invited
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] 唾液中低分子バイオマーカーのLC/MS/MS
- Author(s)
  東　達也
- Organizer
  第60回日本臨床検査医学会学術集会
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PROJECT-23590046
[Presentation] ESI増強重水素標識Cookson型試薬を用いる尿中ビタミンD3代謝物のLC/MS/MS定量法の開発
- Author(s)
  小川祥二郎，大木　智，篠田健太，東　達也
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23590046

1. Satoh Mamoru (20401002)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
2. SHIMADA Kazutake (90004605)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. OGAWA Shoujiro (30546271)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
4. NOMURA Fumio (80164739)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
5. NISHIMURA Motoi (80400969)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
6. Ishige Takayuki (30757315)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
7. NAMIKI Mikio (70155985)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MIZOKAMI Atsushi (50248580)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. MITAMURA Kuniko (70242526)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. HONMA Seijiro

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. KYO Satoru (50272969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OHSHIMA Hiroshi (80433209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
13. MIYOSHI Noriyuki (70438191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
14. GODA Toshinao (70195923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NUKAYA Haruo (00094342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
16. KADONO Yoshifumi (10397218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MIWA Sotarou (80507070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KOBAYASHI Norihiro (90205477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Sangai Takafumi (00375685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 松下一之 (90344994)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. OGURA Masaru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. SUGIURA Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

higashi tatsuya 東 達也

HIGASHI Tatuya 東 達也

HIGASHI Tatsuya 東 達也

Research Projects

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Development of derivatization method for producing analyte skeleton-containing product ion during MS/MS and its application to specific determination of low-molecular-weight diagnostic markersPrincipal Investigator

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Development of enhanced throughput LC/MS assays of steroid hormones based on sample and analyte-multiplexingPrincipal Investigator

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Development of derivatization procedures using reagent analogues and isotopologues for enhancing throughput of mass spectrometry-based clinical examinationsPrincipal Investigator

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Analysis of new-generation neurosteroids in brain by LC/MS/MS coupled to derivatization with ESI-enhancing and deuterium-labeling reagentsPrincipal Investigator

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Development of multi-point recognizing derivatization procedures for reliable diagnoses of inborn errors of metabolismPrincipal Investigator

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Development and application of determination methods of salivary hormones for noninvasive diagnosis of endocrine disordersPrincipal Investigator

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Trace charactethation of neurosteroids to develop a new antipsychotic agent targeting neurosteroidogenesisPrincipal Investigator

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higashi tatsuya 東達也

HIGASHI Tatuya 東達也

HIGASHI Tatsuya 東達也