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OHKUBO Tadayasu  大久保 忠恭

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… Alternative Names

大久保 忠泰  オオクボ タダヤス

大久保 忠恭  オオクボ タダヤス

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Researcher Number 90272997
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2014: 大阪大学, 薬学研究科(研究院), 教授
2008: 大阪大学, 薬学部, 准教授
2007: Osaka University, 薬学研究科, 准教授
2001 – 2006: 大阪大学, 薬学研究科, 助教授
2005: Osaka University, Graduate School of Pharmaceutical Sciences, Associate Professor, 大学院・薬学研究科, 助教授
1996 – 1998: 北陸先端科学技術大学院大学, 新素材センター, 助教授
1996: 北陸先端科学技術大学院大学, 新素材センター
Review Section/Research Field
Principal Investigator
Structural biochemistry / Biological Sciences / Physical pharmacy
Except Principal Investigator
Physical pharmacy / 医薬分子機能学 / Environmental chemistry / Biophysics / Biological Sciences
Keywords
Principal Investigator
NMR / Ada蛋白質 / 2次構造 / 多次元NMR / ^<15>N-^1H HMQ^C / プロスタグランジンD合成酵素 / EF-G複合体モデル / リボソーム / ドメイン運動 / X線結晶構造解析 … More / RRF / 新規抗菌物質 / リボソーム再生 / 結合エントロピー / ^<15>N核の緩和時間 / レチノイン酸結合 / 多層的変性中間体 / 低濃度変性剤 / 準安定状態 / リポカリン型プロスタグランジンD合成酵素 / DNA結合部位 / 大腸菌Adaタンパク質 / 転写制御 / 機能スイッチ / 金属配位 / DNA修復 … More
Except Principal Investigator
NMR / RRF / 炭酸脱水酵素 / 分子間相互作用 / 水和 / トリプルヘリックス構造 / hydration / partial molar volume / entropy / enthalpy / 4-fluoroproline / 4-hydroxyproline / triple helical structure / collagen model peptides / トリプルヘリックス / コラーゲンモデルペブチド / フルオロプロリン / ヒドロキシプロリン / 部分モル体積 / エントロピー / エンタルピー / 4-フルオロプロリン / 4-ヒドロキシプロリン / コラーゲンモデルペプチド / Drug design / Antibiotics / Interaction / Ribosome / ドラッグデザイン / 抗菌剤 / 相互作用 / リボソーム / CCS / CCS / ナクレイン / 固体炭酸 / 二酸化炭素 / 地球温暖化 / バイオミメティクス / 構造機能相関 / 触媒機構 / MM / QM / プロトン移動 / 反応機構 / 触媒 / 互変異性 / ヒスチジン / 機能 / 酵素 / タンパク質 / 立体構造 / 超分子 / 熱安定性 / 解離会合平衡 / コラーゲン様ドメイン / 多量体形成 / アディポネクチン Less
  • Research Projects

    (11 results)
  • Research Products

    (9 results)
  • Co-Researchers

    (10 People)
  •  Development of Biomimetic System using Carbonic Anhydrase Incorporated into CO2 Capture and Storage - Transformation of CO2 to Solid Bicarbonate -

    • Principal Investigator
      SHIMAHARA Hideto
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental chemistry
    • Research Institution
      Japan Advanced Institute of Science and Technology
  •  NMR and MM Analysis of Tautomerization of His64 Coupled to Ionization of Zinc-bound Solvent during Proton Transfer in Carbonic Anhydrase

    • Principal Investigator
      SHIMAHARA Hideto
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biophysics
    • Research Institution
      Japan Advanced Institute of Science and Technology
  •  リボソーム-RRF複合体の立体構造にもとづく機能解明と創薬への応用Principal Investigator

    • Principal Investigator
      大久保 忠恭
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  アディポネクチンの超分子構造・相互作用解析

    • Principal Investigator
      KOBAYASHI Yuji
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University of Pharmaceutical Sciences
      Osaka University
  •  Investigation of the Stabilizing Mechanism of Collagen

    • Principal Investigator
      KOBAYASHI Yuji
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Osaka University of Pharmaceutical Sciences
      Osaka University
  •  The development of NMR methods for drug discovery targeting on ribosome recycling.

    • Principal Investigator
      KOBAYASHI Yuji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      Osaka University
  •  プロスタグランジンD合成酵素の変性剤による準安定状態の解明Principal Investigator

    • Principal Investigator
      大久保 忠恭
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Physical pharmacy
    • Research Institution
      Osaka University
  •  大腸菌Ada蛋白質-DNA複合体の立体構造解析と認識機構Principal Investigator

    • Principal Investigator
      大久保 忠恭
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Japan Advanced Institute of Science and Technology
  •  DNA修復蛋白質Adaの転写制御スイッチ機構の解明と亜鉛原子の役割Principal Investigator

    • Principal Investigator
      大久保 忠恭
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Japan Advanced Institute of Science and Technology
  •  大腸菌Ada蛋白質-DNA複合体の立体構造解析と認識機構Principal Investigator

    • Principal Investigator
      大久保 忠恭
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Japan Advanced Institute of Science and Technology
  •  プロスタグランジンD合成酵素の立体構造決定と反応機構の解明Principal Investigator

    • Principal Investigator
      大久保 忠泰 (大久保 忠恭)
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      Japan Advanced Institute of Science and Technology

All 2013 2012 2008 2007

All Journal Article Presentation Book

  • [Book] Chromosome Nanoscience and Technology (Ed. Fukui K. and Ushiki T.)2007

    • Author(s)
      Ohkubo, T., et. al.
    • Publisher
      Structure and Interactions of the Imitation SWI-Type Chromatin-Remodeling Complex, ATP-Dependent Chromatin-Assembly Factor
    • Data Source
      KAKENHI-PROJECT-18054021
  • [Journal Article] An Approach to Water Molecule Dynamics Associated with Motion of Catalytic Moiety2013

    • Author(s)
      Hideto Shimahara*, Kimikazu Sugimori, Muhmad Koyimatu, Hidemi Nagao, Tadayasu Ohkubo, and Yuji Kobayashi
    • Journal Title

      AIP Conf. Proc.

      Volume: 1518 Pages: 610-613

    • DOI

      10.1063/1.4794643

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24550173
  • [Journal Article] Tautomerism of histidine 64 associated with proton transfer in catalysis of Carbonic Anhydrase2008

    • Author(s)
      島原秀登, 吉田卓也, 水上卓, 中沢隆, 長尾秀実, 大久保忠恭, 小林祐次, (他2名, 1番目)
    • Journal Title

      FASEB Journal 22巻

    • Data Source
      KAKENHI-PROJECT-19770128
  • [Journal Article] Tautomerism of histidine 64 associated with proton-transfer in catalysis of carbonic anhydrase2007

    • Author(s)
      島原秀登, 吉田卓也, 中沢隆, 大久保忠恭, 小林祐次, (他10名,1番目)
    • Journal Title

      J Biol Chem 282巻

      Pages: 9646-56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19770128
  • [Presentation] An Approach to Water Molecule Dynamics Associated with Motion of Catalytic Moiety2012

    • Author(s)
      Hideto Shimahara, Kimikazu Sugimori, Muhmad Koyimatu, Hidemi Nagao, Tadayasu Ohkubo, and Yuji Kobayashi
    • Organizer
      The 4th International Symposium on Slow Dynamics in Complex Systems
    • Place of Presentation
      Sendai
    • Data Source
      KAKENHI-PROJECT-24550173
  • [Presentation] 溶液NMR法を用いた炭酸脱水酵素の亜鉛結合水のpKaの決定―H/D交換によるHis-溶媒接触の可能性―2012

    • Author(s)
      島原秀登,杉森公一,Koyimatu Muhamad,吉田卓也,長尾秀実,中澤隆,大久保忠恭,小林祐次
    • Organizer
      第12回蛋白質科学会年会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-24550173
  • [Presentation] Hydrogen-bonding Network and His64 in Carbonic Anhydrase,炭酸脱水酵素の水素結合ネットワークとHis62012

    • Author(s)
      Muhamad Koyimatu,島原秀登,杉森公一,岩山将士,杉森哲也,川口一朋,齊藤大明,吉田卓也,中沢隆,大久保忠恭,小林祐次,長尾秀実
    • Organizer
      第6回分子科学討論会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24550173
  • [Presentation] NMR Approach to His-64 Involved in Proton-Transfer Mechanism in Catalysis of Carbonic Anhydrase2007

    • Author(s)
      島原秀登, Shimahara, H., Yoshida, T., Nakazawa, T., Ohkubo, T., & Kobayashi, Y.
    • Organizer
      12th European Conference on the Spectroscopy of Biological Molecules
    • Place of Presentation
      Paris, France
    • Data Source
      KAKENHI-PROJECT-19770128
  • [Presentation] リポカリン型プロスタグランジンD合成酵素の溶液構造とリガンド結合様式2007

    • Author(s)
      大久保忠恭
    • Organizer
      特定領域研究「生体超分子の構造形成と機能制御の原子
    • Place of Presentation
      静岡県熱海市ホテルニューア
    • Year and Date
      2007-07-11
    • Data Source
      KAKENHI-PROJECT-18054021
  • 1.  KOBAYASHI Yuji (20127228)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 7 results
  • 2.  YOSHIDA Takuya (00294116)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 3.  SHIMAHARA Hideto (40313704)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 4.  NAGAO Hidemi (30291892)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 5.  SUGIMORI Kimikazu (40581632)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 6.  NAKAZAWA Takashi (30175492)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  SAKIYAMA Fumio (40029947)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MIZUKAMI Taku (50270955)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  NISHI Yoshinori (70397727)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  裏出 良博 (10201360)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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