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Matsumoto Shigekiyo  松本 重清

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MATSUMOTO Shigekiyo  松本 重清

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Researcher Number 90274761
Other IDs
Affiliation (Current) 2025: 大分大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2011 – 2024: 大分大学, 医学部, 准教授
2010: 大分大学, 医学部, 講師
2008 – 2009: 大分大学, 医学部, 助教
2005: 大分大学, 医学部, 助手
2004: 大分大学, 脳・神経機能統御講座, 助手
2003: Oita University, Faculty of Medicine, Assistant Professor, 医学部, 助手
2002: 大分医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 55050:Anesthesiology-related / Anesthesiology / Anesthesiology/Resuscitation studies
Except Principal Investigator
Basic Section 55060:Emergency medicine-related / Basic Section 55050:Anesthesiology-related / Anesthesiology / Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies
Keywords
Principal Investigator
酸化ストレス / ビタミンC / 急性腎傷害 / 炎症反応 / 術後せん妄 / 電子スピン共鳴 / 敗血症 / アスコルビン酸 / 呼気中揮発性代謝産物 / 水晶振動子ガスセンサシステム … More / 呼気アンモニア / 炎症 / 周術期臓器傷害 / 呼気モニタリング / 術後合併症 / 臓器傷害 / 術中バイオマーカー / 臓器傷害早期予測 / 急性腎障害 / 周術期呼気バイオマーカー / 術後臓器障害 / アンモニア / 揮発性有機化合物 / 抗酸化療法 / 術後認知機能障害 / 周術期せん妄 / 全身性炎症反応 / 副腎機能 / 下垂体・副腎ホルモン / 副腎皮質・髄質ホルモン / 下垂体ホルモン / 敗血症性ショック / SMP30/GNLノックアウトマウス / コルチゾール / カテコラミン / 副腎皮質ホルモン / 副腎髄質ホルモン / 下垂体後葉ホルモン / ビタミン / ETS-GS / 副腎不全 / ヒドロキシルラジカル / 電子スピン共鳴法 / アスコルビン酸ラジカル / 脳分離体外循環 / 弓部大動脈置換術 / 脳虚血 / フリーラジカル … More
Except Principal Investigator
フリーラジカル / 抗酸化作用 / 酸化ストレス / 電子スピン共鳴 / ビタミンC / ラジカル消去能 / 電子スピン共鳴法 / 周術期合併症 / 電子スピン共鳴装置 / ラジカル消去作用 / 核磁気共鳴法 / スピン共鳴解析 / 抗酸化能 / 質量分析イメージング / 局所麻酔薬 / RT-PCR / reactive oxygen species / 重症熱性血小板減少症候群 / レミマゾラム / 認知機能傷害 / 光治療 / 認知機能障害 / 概日リズム / 光療法 / 敗血症 / 抗酸化物質 / 心停止 / 治療介入 / 心停止後症候群 / 酸化増強 / 抗酸化 / 局所麻酔 / TBARSアッセイ / ESR / NMR / スピンメタボロミクス / ラジカル / VCR/DMSO / 補充療法 / 救急患者 / 重症外傷 / 外傷 / μオピオイド受容体作動薬 / 術後認知機能障害 / remifentanil / レミフェンタニル / 脳エネルギー代謝 / 虚血-再灌流負荷 / スピン解析 / 虚血再灌流傷害 / Dexmedetomidine / フリーラジカル消去能 / NMRメタボロミクス / 高エネルギーリン酸 / 水溶性αリポ酸誘導体 / フリーラジカル消去作用 / local anesthetics / hemodynamics / Pnumoperitoneum / ADH / 循環動態 / 気腹 / 脳低体温療法 / 全脳虚血 Less
  • Research Projects

    (18 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (17 People)
  •  Breath ammonia detection predicts acute kidney injury and postoperative delirium earlier in the perioperative periodPrincipal Investigator

    • Principal Investigator
      松本 重清
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Oita University
  •  Oxidative stress control and Vitamin C replacement therapy for Severe Fever with Thrombocytopenia Syndrome

    • Principal Investigator
      竹中 隆一
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Oita University
  •  Anti-oxidative activity of Remimazolam

    • Principal Investigator
      徳丸 治
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Oita University
  •  周術期合併症に関する予測因子の基礎的検討-スピンメタボロミクスの臨床応用

    • Principal Investigator
      新宮 千尋
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Oita University
  •  Real-time monitoring of breath volatile organic compounds for early detection of perioperative organ injuryPrincipal Investigator

    • Principal Investigator
      MATSUMOTO SHIGEKIYO
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Oita University
  •  Are local anesthetics antioxidants or prooxidants?

    • Principal Investigator
      Kitano Takaaki
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Oita University
  •  Assessment of oxidative stress and therapeutic intervention in cases of cardiac arrest and Post-Cardiac Arrest Syndrome

    • Principal Investigator
      重光 修
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Oita University
  •  Light elicited circadian re-entrainment as a treatment for post-sepsis cognitive impairment

    • Principal Investigator
      小山 淑正
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Oita University
  •  Antioxidative activity of remifentanil: Does remifentanil directly scavenge free radicals?

    • Principal Investigator
      Tokumaru Osamu
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Oita University
  •  Establishment of additional Vitamin C therapy for the suppression of oxidative stress from patients with severe traumatic injury

    • Principal Investigator
      Takenaka Ryuichi
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Oita University
  •  Antioxidative effect of dexmedetomidine by spin resonance analysis

    • Principal Investigator
      Kitano Takaaki
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Oita University
  •  Antioxidative therapy for prevention of postoperative delirium and cognitive dysfunctionPrincipal Investigator

    • Principal Investigator
      Matsumoto Shigekiyo
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Oita University
  •  Antioxidative and neuroprotective activity of alpha-lipoic acid derivatives: spin resonance analyses

    • Principal Investigator
      Tokumaru Osamu
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Oita University
  •  A new endocrinological mechanism of septic shock and vitamin C supplementation in septic shock under real-time vitamin C monitoring with electron spin resonance spectroscopyPrincipal Investigator

    • Principal Investigator
      Matsumoto Shigekiyo
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Oita University
  •  A new strategy for adrenal insufficiency in septic shock: a new antioxdant ETS-GSPrincipal Investigator

    • Principal Investigator
      MATSUMOTO Shigekiyo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Oita University
  •  Assessing the severity of patients in therapeutic hypothermia for brain -ESR study-

    • Principal Investigator
      SHINGU Chihiro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Oita University
  •  血中フリーラジカルの経時的変化による脳虚血の検出:電子スピン共鳴法を用いた検討Principal Investigator

    • Principal Investigator
      松本 重清
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Oita University
      大分医科大学
  •  Effect of. local anesthetics on cerebral and abdominal organ injury during pneumoperitoneum

    • Principal Investigator
      YOSHITAKE Shigenori
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Oita University (Faculty of Medicine)

All 2023 2022 2021 2020 2019 2017 2016 2010

All Journal Article Presentation

  • [Journal Article] The dose-response relationships of the direct scavenging activity of amide-based local anesthetics against multiple free radicals2023

    • Author(s)
      Sato Yukiko, Matsumoto Shigekiyo, Ogata Kazue, Kira Bacal, Nakatake Misato, Kitano Takaaki, Tokumaru Osamu
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 73 Issue: 1 Pages: 16-23

    • DOI

      10.3164/jcbn.22-131

    • ISSN
      0912-0009, 1880-5086
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09329, KAKENHI-PROJECT-22K09073, KAKENHI-PROJECT-20K09249
  • [Journal Article] Real-time monitoring of vitamin C levels in trauma patients by electron-spin resonance spectrometry2023

    • Author(s)
      Takenaka Ryuichi、Matsumoto Shigekiyo、Nureki Shinichi、Wada Shinsuke、Oyama Yoshimasa、Sakamoto Teruo、Kitano Takaaki、Shigemitsu Osamu
    • Journal Title

      BMC Emergency Medicine

      Volume: 23 Issue: 1

    • DOI

      10.1186/s12873-023-00857-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09437
  • [Journal Article] Dose-dependent scavenging activity of the ultra-short-acting β1-blocker landiolol against specific free radicals2022

    • Author(s)
      Matsumoto Shigekiyo、Tokumaru Osamu、Ogata Kazue、Kuribayashi Yoshihide、Oyama Yoshimasa、Shingu Chihiro、Yokoi Isao、Kitano Takaaki
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 71 Issue: 3 Pages: 185-190

    • DOI

      10.3164/jcbn.21-157

    • ISSN
      0912-0009, 1880-5086
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09249, KAKENHI-PROJECT-22K09073, KAKENHI-PROJECT-19K09329
  • [Journal Article] Direct free radical scavenging effects of water-soluble HMG-CoA reductase inhibitors2019

    • Author(s)
      Umeda Ryohei、Takanari Hiroki、Ogata Kazue、Matsumoto Shigekiyo、Kitano Takaaki、Ono Katsushige、Tokumaru Osamu
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 64 Issue: 1 Pages: 20-26

    • DOI

      10.3164/jcbn.18-48

    • NAID

      130007542260

    • ISSN
      0912-0009, 1880-5086
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11087, KAKENHI-PROJECT-16H05238, KAKENHI-PROJECT-15K10515, KAKENHI-PROJECT-16K09964, KAKENHI-PROJECT-19H04443
  • [Journal Article] An Electron Spin Resonance Study for Real-time Detection of Ascorbyl Free Radicals After Addition of Dimethyl Sulfoxide in Murine Hippocampus or Plasma During Kainic Acid-Induced Seizures2010

    • Author(s)
      Matsumoto S, Shingu C, Koga H, Hagiwara S, Iwasaka H, Noguchi T, Yokoi I
    • Journal Title

      Neurochemical Research (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591808
  • [Journal Article] An Electron Spin Resonance Study for Real-time Detection of Ascorbyl Free Radicals After Addition of Dimethyl Sulfoxide in Murine Hippocampus or Plasma During Kainic Acid-Induced Seizures.2010

    • Author(s)
      Matsumoto S, Shingu C, Koga H, Hagiwara S, Iwasaka H, Noguchi T, Yokoi I.
    • Journal Title

      Neurochem Res. 35(7)

      Pages: 1010-1016

    • Data Source
      KAKENHI-PROJECT-20591808
  • [Journal Article] The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury : an electron spin resonance study2010

    • Author(s)
      Matsumoto S, Shingu C, Koga H, Hidaka S, Goto K, Hagiwara S, Iwasaka H, Noguchi T, Yokoi I.
    • Journal Title

      Journal of Trauma 68

      Pages: 796-801

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591808
  • [Journal Article] The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury : an electron spin study.2010

    • Author(s)
      Matsumoto S, Shingu C, Koga H, Hidaka S, Goto K, Hagiwara S, Iwasaka H, Noguchi T, Yokoi I.
    • Journal Title

      Journal of Trauma 68

      Pages: 796-801

    • Data Source
      KAKENHI-PROJECT-20591808
  • [Presentation] アミド型局所麻酔薬のフリーラジカル消去活性の評価2023

    • Author(s)
      佐藤祐貴子,松本重清,尾方和枝,中武聖,栗林由英,北野敬明,徳丸治
    • Organizer
      第76回日本酸化ストレス学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K09073
  • [Presentation] アミド型局所麻酔薬のフリーラジカル消去活性の評価2023

    • Author(s)
      佐藤祐貴子,松本重清,尾方和枝,中武聖,栗林由英,北野敬明,徳丸治
    • Organizer
      第76回日本酸化ストレス学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K09249
  • [Presentation] Antioxidative activity of remifentanil as a direct free radical scavenger2022

    • Author(s)
      Osamu Tokumaru, Leon Yamasaki, Kazue Ogata, Shigekiyo Matsumoto, Takaaki Kitano
    • Organizer
      第96回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K09249
  • [Presentation] 波長別LED全身照射が概日リズムや酸化ストレスに及ぼす影響2022

    • Author(s)
      小山淑正、小坂麻里子、尾方和枝、松本重清、北野敬明
    • Organizer
      第36回日本Shock学会総会
    • Data Source
      KAKENHI-PROJECT-20H03783
  • [Presentation] 待機的心臓・大血管手術における術後譫妄と炎症および酸化ストレスの関連ー新規予防戦略の提案ー2022

    • Author(s)
      栗林由英,松本重清,小山淑正,日高正剛,新宮千尋,北野敬明
    • Organizer
      日本麻酔科学会第69回学術集会
    • Data Source
      KAKENHI-PROJECT-17K11088
  • [Presentation] Antioxidative activity of remifentanil as a direct free radical scavenger2022

    • Author(s)
      Osamu Tokumaru, Leon Yamasaki, Kazue Ogata, Shigekiyo Matsumoto, Takaaki Kitano
    • Organizer
      第96回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K09329
  • [Presentation] Antioxidative activity of remifentanil as a direct free radical scavenger2022

    • Author(s)
      Osamu Tokumaru, Leon Yamasaki, Kazue Ogata, Shigekiyo Matsumoto, Takaaki Kitano
    • Organizer
      第96回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-22K09073
  • [Presentation] 待機的心臓・大血管手術における高齢者術後譫妄には酸化ストレスが関与するー電子スピン共鳴(ESR)装置を用いた検討ー2021

    • Author(s)
      栗林由英、松本重清、小山淑正、北野敬明
    • Organizer
      第33回日本老年麻酔学会
    • Data Source
      KAKENHI-PROJECT-17K11088
  • [Presentation] Antioxidative activity of ketamineas a direct radical scavenger2021

    • Author(s)
      Tokumaru O, Ozaki Y, Kawano T, Ogata K, Eshima N, Matsumoto S, Kitano T
    • Organizer
      第95回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K09329
  • [Presentation] 心臓・大血管疾患に対する待機的手術における術後譫妄とビタミンCの関連ー電子スピン共鳴装置を用いた検討ー2021

    • Author(s)
      栗林由英、松本重清、小山淑正、新宮千尋、尾方和枝、北野敬明
    • Organizer
      日本麻酔科学会第68回学術集会
    • Data Source
      KAKENHI-PROJECT-17K11088
  • [Presentation] Serum Vitamin C Levels were decreased in Severe Emergency Patients2020

    • Author(s)
      Ryuichi Takenaka、Nureki Shinichi、Kiyoshige Matsumoto、Osamu Shigemitsu
    • Organizer
      40th ISICEM/Web発表
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09437
  • [Presentation] Serum Vitamin C Levels were decreased in Severe Emergency Patients2020

    • Author(s)
      ①Ryuichi Takenaka、Nureki Shinichi、Kiyoshige Matsumoto、Osamu Shigemitsu
    • Organizer
      40th ISICEM(国際救急集中治療会議)/Web発表
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09290
  • [Presentation] Antioxidative activity of dexmedetomidine as a direct free radical scavenger2019

    • Author(s)
      Kazue O, Yoshida K, Matsumoto S, Shingu C, Kitano T, Tokumaru O
    • Organizer
      第93回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-17K11087
  • [Presentation] 電子スピン共鳴法によるデクスメデトミジンのフリーラジカル消去能の検討2019

    • Author(s)
      西田太一, 徳丸治, 松本重清, 内野哲哉, 新宮千尋, 北野敬明
    • Organizer
      日本麻酔科学会
    • Data Source
      KAKENHI-PROJECT-17K11087
  • [Presentation] Direct observation of ascorbyl free radicals (vitamin C radicals) in blood of perioperative animals2017

    • Author(s)
      Osamu Tokumaru, Shigekiyo Matsumoto, Takayuki Mizoguchi, Takayuki Kawashima, Kazue Ogata, Shinji Miyamoto, Takaaki Kitano
    • Organizer
      第95回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-17K11087
  • [Presentation] Direct observation of ascorbyl free radicals (vitamin C radicals) in blood of perioperative animals2017

    • Author(s)
      Osamu Tokumaru, Shigekiyo Matsumoto, Takayuki Mizoguchi, Takayuki Kawashima, Kazue Ogata, Shinji Miyamoto, Takaaki Kitano
    • Organizer
      第95回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-15K10515
  • [Presentation] 周術期の血液から検出されるアスコルビン酸フリーラジカルについて2016

    • Author(s)
      徳丸治,松本重清,岡本啓太郎,溝口貴之,尾方和枝.北野敬明
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台国際センター会議棟(宮城県・仙台市)
    • Year and Date
      2016-08-30
    • Data Source
      KAKENHI-PROJECT-15K10515
  • 1.  Tokumaru Osamu (40360151)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 11 results
  • 2.  SHINGU Chihiro (30295191)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 6 results
  • 3.  Kitano Takaaki (20211196)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 11 results
  • 4.  Takenaka Ryuichi (90457606)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 5.  江島 伸興 (20203630)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  重光 修 (40215968)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 7.  濡木 真一 (50423702)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 8.  安部 隆三 (30375795)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  李 丞祐 (60326460)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  YOKOI Isao (80150366)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 11.  NOGUCHI Takayuki (90156183)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 12.  YOSHITAKE Shigenori (10200974)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  西田 育弘 (90172668)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  小山 淑正 (40468012)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  穴井 博文 (20291544)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  KOGA Hironori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  ISHIGAMI Akihito
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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