KOJIMA MASAKI 小島正樹

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KOJIMA Masaki 小島正樹

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Researcher Number	90277252
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Affiliation (Current)	2022: 東京薬科大学, 生命科学部, 教授
Affiliation (based on the past Project Information) *help	2015: 東京薬科大学, 生命科学部, 教授 2008 – 2011: 東京薬科大学, 生命科学部, 教授 2007: Iwate Medical University, School of Pharmacy, Associate Professor 2006: 東京薬科大学, 生命科学部, 助教授 2005: 東京薬科大学, 生命科学部, 講師 1996 – 2002: Tokyo University of Pharmacy and Life Science, Department of Life Science, Assis, 生命科学部, 助手
Review Section/Research Field	Principal Investigator Biophysics / Physical pharmacy Except Principal Investigator Structural biochemistry / Analytical chemistry / Biological pharmacy / Structural biochemistry / 応用微生物学・応用生物化学 / 医薬分子機能学 / Virology
Keywords	Principal Investigator リボヌクレアーゼT_1 / カルボキシメチル化 / NMR / シミュレーション / 分子動力学法 / 自由エネルギー摂動法 / 分子軌道法 / HIVプロテアーゼ / 変性 / X線溶液散乱 / フォールディング … More Except Principal Investigator … More Bacillus brevis / Fab / Brugia malayi / グルタチオントランスフェラーゼ / 融合遺伝子 / アスパラギン酸プロテアーゼ / システインプロテアーゼ / フィラリア / プロテアーゼ / 金属プロテアーゼ / 蛋白工学 / 部位特異的変異 / X線結晶構造解析 / 基質特異性 / チオレドキシン / グルタチオン / 触媒機構 / 抗体Fab断片 / シグナルペプチド / 単鎖抗体 / 分泌 / α-アミラーゼ / CH1ドメイン / パーキンソン病 / ドパミン / アミロイド / 生物物理 / α-synuclein / エンテロペプチダーゼ / ヘプシン / トリプシン / プロガストリン分解プロテアーゼ / Cryptic plasmid / 線虫 / Caenorhabditis elegans / RNAi / cDNA / filaria / ハロゲン化炭化水素 / 脱ハロゲン化 / グルタチオンS-トランスフェラーゼ / 活性部位残基 / 環境汚染物質 / タンパク質立体構造 / X線結晶解析 / 薬物代謝酵素 / 静電ポテンシャル / 分子動力学 / 生物学的分析 / a-synuclein / アミロイド線維 / オリゴマー中間体 / 高分子構造・物性 / 脳神経疾患 / 生理物理 / 分析化学 / タンパク質 / X線構造解析 / 蛋白質 / X線溶液散乱 / 分子動力学計算 / キチナーゼ / 酵素反応 / 糖鎖 / 分子認識 / アミロイド繊維化 / オリゴマー形成 / 胃・腸管系プロテアーゼ / VIP分解エンドペプチダーゼ / 胃トリプシン / ペプシノーゲン / α_2マクログラブリン / α_2マクログロブリン / プロリルエンドペプチダーゼ / αキモトリプシン / β-アミロイドペプチド / 細胞内トリプシン / プロセシング / 蛋白分解 / gastrointestinal proteinase / VIP-degrading endopeptidase / gastric trypsin / enteropeptidase / hepsin / pepsinogen / _2-macroglobulin / trypsin / フィラリア・プロテアーゼ / cDNAライブラリー / システイン・プロテアーゼ / クローニング / 塩基配列決定 / ヒト・フィラリア / ウシ・フィラリア / フィラリアプロテアーゼ / カテプシンロ / ガストリックシン / カテプシンS / カテプシンD / 塩基配列解析 / PCR / Filarial proteinase / cDNA Library / Aspartic proteinase / Cryteine proteinase / Cloning / Base sequence analysis / Human filaria / Bovine filaria / 脳・腸管系プロテアーゼ / CAAXモチーフ特異的プロテアーゼ / コロプシン / カテプシンE / 膜結合プロテアーゼ / カテプシンE遺伝子 / 膜結合性プロテアーゼ / セリンプロテアーゼ / CAAX-モチーフ特異的プロテアーゼ / α-キモトリプシン / Brain-gut proteinase / Progastrin-cleaving proteinase / CAAX-motif-specific proteinase / Hepsin / Colopsin / Cathepsin E / Membrane-bound proteinase / Proteinase / 分泌ベクター / cryptic plasmid / eryptic plasmid / 宿主ベクター系 / プロモーター / SD配列 / 抗体Fab′断片 / 分泌生産 / Secretion-vector / Single-chain antibody / ポストゲノム / 寄生虫 / 阻害剤 / nematode / protease / post genome / parasite / マレー系状虫 / 脱ユビチキン化プロテアーゼ / cDNAクローニング / 異宿主発現 / マレー糸状虫 / 組織内分布 / 抗体染色 / Aspartic protease / cysteine protease / metalloprotease / deubiquitinating enzyme / cDNA cloning / heterologous expression / アミロイド線維形成 / アルツハイマー病 / 家族性パーキンソン病 / α-シヌクレイン / 中間体 / NACP / amyloid fibrils / Alzheimer's disease / familial Parkinson's disease / intermediate / 遺伝子治療 / 腫瘍溶解性ウイルス療法 / ヘルペスウイルス / 抗体 / がん Less

Development of highly specific oncolytic herpes virus vectors by modification of two envelope glycoproteins
- Principal Investigator
  
  Uchida Hiroaki
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Virology
- Research Institution
  The University of Tokyo
アミロイド化初期段階におけるドパミンによるオリゴマー形式の高精度検出法の開発
- Principal Investigator
  
  田代櫻子
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Analytical chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Elucidation of structure and function relationship in multiple-domain chitinases probed by a combination of X-ray crystallography, solution scattering, and molecular dynamics simulation
- Principal Investigator
  
  NONAKA Takamasa
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Iwate Medical University
Studies of an early stage amyloid formation for Parkinson`s Disease casual protein.
- Principal Investigator
  
  TASHIRO Sakurako
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Analytical chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Development of high precision method to detect amyloid formation for Alzheimer's disease
- Principal Investigator
  
  TASHIRO Sakurako
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Analytical chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
フォールディング機構に基づくHIVプロテアーゼの不活性化Principal Investigator
- Principal Investigator
  
  小島正樹
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
バイオターゲティング素子としての抗体断片の高効率生産と構造機能解析
- Principal Investigator
  
  山形秀夫
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo University of Pharmacy and Life Science
バイオターゲティング素子としての抗体断片の高効率生産と構造機能解析
- Principal Investigator
  
  山形秀夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo University of Pharmacy and Life Science
Post-genome study on filarial proteases for development of inhibitors.
- Principal Investigator
  
  HIDESHI Inoue
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo University of Pharmacy and Life Science
Molecular Biological Studies on the Proteases and .Their Inhibifors of Filarial Parasites
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化
- Principal Investigator
  
  井上英史
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo University of Pharmacy and Life Science
バイオターゲッティング素子としての抗体断片の高効率生産と構造機能解析
- Principal Investigator
  
  YAMAGATA Hideo
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo University of Pharmacy and Life Science
チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化
- Principal Investigator
  
  井上英史
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Pharmacy and Life Science
Structural, Functional and Physiological Characterization of Novel Brain-Gut Proteinases
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
A systematic analysis of the effects of fine-structures of antibodies on microbial expression and secretion and construction of a general-purpose system for antibody production.
- Principal Investigator
  
  YAMAGATA Hideo
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Tokyo University of Pharmacy and Life Science
環境汚染物質の除去を目的としたハロゲン化炭素水素代謝酵素の蛋白工学的研究
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Pharmacy and Life Science
立体構造と蛋白工学的解析に基づくグルタチオン・トランスフェラーゼの機能発現機構
- Principal Investigator
  
  井上英史
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
リボヌクレアーゼT_1の構造・機能相関の物理化学的解析Principal Investigator
- Principal Investigator
  
  小島正樹
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Tokyo University of Pharmacy and Life Science
Studies on Filarial Proteinases and Their Inhibitors for Development of Filarial Drugs
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Systematic search for novel proteinases in gastrointestinal tract and studies on their physiological roles and structure/function
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2010 2008 2007 2005

All Journal Article Presentation

[Journal Article] Structure of full-length class I chitinase from rice revealed by X-ray crystallography and small-angle2010
- Author(s)
  Kezuka, Y., Kojima, M., Mizuno, R., Suzuki, K., Watanabe, T. & Nonaka, T
- Journal Title
  
  X-ray scattering Proteins
  
  Volume: 78 Pages: 2295-2305
- Data Source
  KAKENHI-PROJECT-21570119
[Journal Article] Characterization of Fibrillation Process of α-Synuclein at the initial stage2008
- Author(s)
  Tashiro, M., Kojima, M., Kihara, H., Kasai, K., Kamiyoshihara, T., Ueda, K., Shimotakahara, S
- Journal Title
  
  Biochem Biophys Res Commun 369
  
  Pages: 910-914
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17550085
[Journal Article] Characterization of Fibrillation Process of a-Synuclein at the initial stage2008
- Author(s)
  Tashiro M, Kojima M, Kihara, H., Kasai, K., Kamiyoshihara T, Ueda K, Shimotakahara S.
- Journal Title
  
  Biochem Biophys Res Commun (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17550085
[Journal Article] Characterization of Fibrillation Process of α-Synuclein at the initial stage2008
- Author(s)
  Tashiro M, Kojima M, Kihara, H., Kasai, K., Kamiyoshihara T, Ueda K, Shimotakahara S.
- Journal Title
  
  Biochem Biophys Res Commun 369
  
  Pages: 910-914
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17550085
[Journal Article] Characterization of fibrillation process of alpha-synuclein at the initial stage.2008
- Author(s)
  Tashiro M, Kojima M, Kihara H, Kasai K, Kamiyoshihara T, Ueda K, Shimotakahara S.
- Journal Title
  
  Biochem Biophys Res Commun. 369(3)
  
  Pages: 910-914
- Data Source
  KAKENHI-PROJECT-20550083
[Journal Article] Observation of multiple intermediates in alpha-synuclein fibril formation by singular value decomposition analysis2007
- Author(s)
  Kamiyoshihara, T., Kojima, M., Ueda, K., Tashiro, M., Shimotakahara, S
- Journal Title
  
  Biochem Biophys Res Commun 355(2)
  
  Pages: 398-403
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17550085
[Journal Article] Obseration of multiple intermediates in alpha-synuclein fibril formation by singular value decomposition analysis2007
- Author(s)
  Kamiyoshihara T, Kojima M, Ueda K, Tashiro M, Shimotakahara S.
- Journal Title
  
  Biochem Biophys Res Commun 355
  
  Pages: 398-403
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17550085
[Journal Article] Observation of multiple intermediates in alpha-synuclein fibril formation by singular value decomposition analysis2007
- Author(s)
  Kamiyoshihara T, Kojima M, Ueda K, Tashiro M, Shimotakahara S.
- Journal Title
  
  Biochem Biophys Res Commun 355
  
  Pages: 398-403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17550085
[Presentation] パーキンソン病原因タンパク質α-synucleinの初期段階アミロイド形成機構の解明2008
- Author(s)
  笠井恒希,田代充,小島正樹,木原裕,上田健治,上吉原智晃,田代(下高原)櫻子
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20550083
[Presentation] パーキンソン病原因タンパク質a-synucleinの初期段階アミロイド形成機構の解明2008
- Author(s)
  笠井恒希, 田代充, 小島正樹, 木原裕, 上田健治, 上吉原智晃, 田代(下高原)櫻子
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20550083
[Presentation] パーキンソン病原因タンパク質alpha-synucleinのアミロイド線維形成の解析2007
- Author(s)
  田代充・田代桜子・上吉原智晃・小島正樹・上田健冶
- Organizer
  第68回分析化学討論会
- Place of Presentation
  宇都宮大学峰キャンパス
- Year and Date
  2007-05-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17550085
[Presentation] パーキンソン病原因タンパク質a-synucleinのアミロイド線維形成の解析2007
- Author(s)
  田代櫻子, 上吉原智晃, 小島正樹, 上田健治, 田代充
- Organizer
  日本薬学会第129年会
- Place of Presentation
  富山
- Year and Date
  2007-03-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17550085
[Presentation] Study of amyloid formation mechanism using alpha-synuclein from Parkinson's disease2007
- Author(s)
  Shimotakahara, Tashiro, S., Kamiyoshihara, T., Kojima, M., Ueda, K., Tashiro, M.
- Organizer
  129th Annual Pharmacy Society Meeting
- Place of Presentation
  Toyama, Japan
- Year and Date
  2007-03-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17550085
[Presentation] Analysis of amyloid formation mechanism using alpha-synuclein from Parkinson's disease2007
- Author(s)
  Tashiro, M., Shimotakahara, Tashiro, S., Kamiyoshihara, T., Kojima, M., Ueda, K
- Organizer
  68th Analytical Chemistry Forum
- Place of Presentation
  University of Utsunomiya, Japan
- Year and Date
  2007-05-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17550085
[Presentation] パーキンソン病関連タンパク質a-synucleinにおけるアミロイド形成機構の解明2005
- Author(s)
  上吉原智晃, 小島正樹, 宮本怜, 上田健治, 田代充, 神藤季三郎, 下高原桜子
- Organizer
  第28回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2005-12-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17550085
[Presentation] Analysis of amyloid formation mechanism using alpha-synuclein from Parkinson's disease2005
- Author(s)
  Kamiyoshihara, T., Kojima, M., Miyamoto, R., Ueda, K., Tashiro, M., Shindo, H., Shimotkahara, S
- Organizer
  28th Annual Molecular Biology Society Meeting
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2005-12-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17550085

1. INOUE Hideshi (20184765)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. TAKAHASHI Kenji (70011533)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
3. YAMAGATA Hideo (20023468)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. OHTA Toshihiro (10266893)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. TASHIRO Sakurako (40328555)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
6. TASHIRO Mitsuru (40315750)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
7. NONAKA Takamasa (30242457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. KEZUKA Yuichiro (50397163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. NISHII Wataru (30287461)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. UDAKA Shigezo (70023463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Uchida Hiroaki (20401250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TAHARA HIDEAKI (70322071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IWASA Susumu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SENARCTH Dis

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. R.WEERAPPULI ウィーラプリアール

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ATHAUDA Sena

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ATHOUDA Senarath B.P.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. WINALASIRI Weerappuli R.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. DISSONAYAKE Senarath

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SENARATH Dis

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. WEELAPPULI R

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. SENARATH B.P

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. DISSANAYAKE セナラッツ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. WIMALASIRI W

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. DISSANAYAKE セナラッツ.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOJIMA MASAKI 小島 正樹

KOJIMA Masaki 小島 正樹

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KOJIMA MASAKI 小島正樹

KOJIMA Masaki 小島正樹