Hirooka Yoshitaka 廣岡良隆

… Alternative Names

HIROOKA Yoshitaka 廣岡良隆

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Researcher Number	90284497
Other IDs
External Links
Affiliation (Current)	2024: 国際医療福祉大学, 医学研究科, 教授 2024: 国際医療福祉大学, 福岡保健医療学部, 教授
Affiliation (based on the past Project Information) *help	2024: 国際医療福祉大学, 福岡保健医療学部, 教授 2017 – 2022: 国際医療福祉大学, 福岡保健医療学部, 教授 2015 – 2016: 九州大学, 学内共同利用施設等, 教授 2015 – 2016: 九州大学, 循環器病未来医療研究センター, 教授 2015: 九州大学, 循環器病未来医療研究センター, 准教授 … More 2012 – 2014: 九州大学, 医学(系)研究科(研究院), 教授 2012: 九州大学, 医学研究院, 教授 2011: 九州大学, 大学院・医学研究院, 教授 2010: 九州大学, 病院, 講師 2004 – 2010: Kyushu University, Coronary Care Unit, Kyushu University Hospital, Assistant Professor, 大学病院, 講師 2005 – 2006: 九州大学, 病院・講師 2003: 九州大学, 医学部附属病院, 講師 2002: Kyushu University Hospital, Department of Cardiovascular Medicine, Assistant Professor, 医学部附属病院, 助手 2000 – 2001: Kyushu Univ, Dept of Cardiovasc Med, Assist Prof, 医学部・附属病院, 助手 1997 – 1999: 九州大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / Cardiovascular medicine / Kidney internal medicine Except Principal Investigator Circulatory organs internal medicine / Biomedical engineering/Biological material science / Basic Section 59010:Rehabilitation science-related / Physical pharmacy
Keywords	Principal Investigator 脳 / 交感神経系 / 血圧 / 心拍数 / 高血圧 / brain / sympathetic nervous system / blood pressure / 遺伝子 / heart rate … More / 循環器・高血圧 / 心不全 / 酸化ストレス / 一酸化窒素 / gene / 活性酸素 / hypertension / Rho-kinase / Rho / gene transfer / nitric oxide / 生理学 / 免疫系 / アンジオテンシンII / レニン・アンジオテンシン系 / 交感神経活動 / 神経体液性因子 / マイクロRNA / 血管内皮機能 / 心臓 / 免疫 / 炎症 / oxidative stress / reactive oxygen species / 交換神経系 / norepinephrine / Reactive oxygen species / ノルエピネフリン / signal transmission / シグナル伝達 / 遺伝子導入 / heart failure / angiotensin / 遺伝子導入法 / アンジオテンシン / 神経科学 / 薬剤反応性 / 生理活性 / 薬理学 / レニン-アンジオテンシン系 / レニンーアンジオテンシン系 / 慢性炎症 / レニン－アンジオテンシン系 / インスリン / メタボリックシンドローム / 肥満 / グルタミン酸受容体 / 延髄 / エンドセリン / 一酸化窒素合成酵素 … More Except Principal Investigator 慢性心不全 / 吸気筋トレーニング / 横隔膜 / Microcirculation / Rho-kinase / Cardiovascular diseases / Atherosclerosis / Nitric oxide / Hydrogen peroxide / Endothelium-derived hyperpolarizing factor / Endothelium-derived relaxing factors / eNOS欠損マウス / NOS欠損マウス / 内皮型NO合成酵素(eNOS) / 内皮由来弛緩因子 / 内皮由来過分極因子(EDHF) / 微小循環 / Rho-キナーゼ / 心血管病 / 動脈硬化 / 一酸化水素 / 過酸化水素 / 内皮由来過分極因子 / 内皮由来池緩因子 / バイオニック / 心不全 / 循環制御 / 自律神経制御 / 生体制御・治療 / 機能的磁気共鳴画像 / 交感神経 / 睡眠時無呼吸 / 酸化ストレス / 交感神経系 / 血圧 / 可視化 / 生体分子 / 生物物理 / 薬学 / 生体医工学 / 自動治療 / 脊髄損傷 / 血圧制御 / バイオニック医学 Less

慢性心不全患者の横隔膜機能低下スクリーニングツールと効果的なトレーニング法の開発
- Principal Investigator
  
  金子秀雄
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  International University of Health and Welfare
Development of novel risk stratification index in hypertensive patients: endothelial function and microRNAPrincipal Investigator
- Principal Investigator
  
  Hirooka Yoshitaka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  International University of Health and Welfare
Mechnistic elucidation and diagnostic development of autonomic nervous system and immunity network in hypertensionPrincipal Investigator
- Principal Investigator
  
  Hirooka Yoshitaka
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  International University of Health and Welfare
Sympathetic activation in heart failure: Elucidation of a novel framework and the control mechanismsPrincipal Investigator
- Principal Investigator
  
  Hirooka Yoshitaka
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
Novel aspects for the role and therapy of autonomic nervous system in pulmonary hypertension toward right ventricular heart failurePrincipal Investigator
- Principal Investigator
  
  HIROOKA Yoshitaka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
Explorations into development of autonomic neuromodulation system to treat refractory heart failure
- Principal Investigator
  
  Sunagawa Kenji
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kyushu University
Imaging study of redox status in vivo in oxidative stress-associateddisease model animals using OMRI
- Principal Investigator
  
  UTSUMI Hideo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyushu University
中枢性睡眠時無呼吸合併慢性心不全患者に対するfMRIを使用した延髄機能異常の解明
- Principal Investigator
  
  江島健一
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
Hypertension in metabolic syndrome : Mechanism involved in activation of the sympathetic nervous system and therapeutic approachPrincipal Investigator
- Principal Investigator
  
  HIROOKA Yoshitaka
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyushu University
Explorations into development of bionic baroreflex system to overcome arterial pressure dysregulation in patients with cervical cord injury
- Principal Investigator
  
  SUNAGAWA Kenji
- Project Period (FY)
  2006 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kyushu University
Role of Racl-derived reactive oxygen species in the vasomotor center of the brain in hypertensionPrincipal Investigator
- Principal Investigator
  
  HIROOKA Yoshitaka
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERCITY
Experimental and Clinical Studies on the Significance of Endothelium-Derived Hyperpolarizing Factor (EDHF)
- Principal Investigator
  
  SHIMOKAWA Hiroaki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tohoku University
  Kyushu University
Role of reactive oxygen species within the vasomotor center of the brain in hypertensionPrincipal Investigator
- Principal Investigator
  
  HIROOKA Yoshitaka
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY
Role of Rho-kinase within the brain in abnormality of regulation of sympathetic nervous system in hypertensionPrincipal Investigator
- Principal Investigator
  
  HIROOKA Yoshitaka
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
Clarification of central nervous system mechanism involved in activation of the sympathetic nervous system in heart failure.Principal Investigator
- Principal Investigator
  
  HIROOKA Yoshitaka
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY
中枢内一酸化窒素による血圧および交感神経活動の調整機序に関する研究Principal Investigator
- Principal Investigator
  
  廣岡良隆
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University

[Book] 腎疾患治療薬　update2021
- Author(s)
  廣岡良隆
- Total Pages
  817
- Publisher
  東京医学社
- Data Source
  KAKENHI-PROJECT-20K08431
[Book] 末梢循環調節．「心不全（第2版）」2018
- Author(s)
  廣岡良隆
- Total Pages
  718
- Publisher
  日本臨床社
- ISBN
- Data Source
  KAKENHI-PROJECT-17K09508
[Book] Oxidative Stress and Central Regulation of Blood Pressure in "Studies on Atherosclerosis"2017
- Author(s)
  Hirooka Y, Sunagawa K.
- Total Pages
  138
- Publisher
  Springer Sciences
- Data Source
  KAKENHI-PROJECT-24390198
[Book] Studies on Atherosclerosis2017
- Author(s)
  Hirooka Y, Sunagawa K (Edited by Rodriguez-Porcel M, Chade AR, Miller JD)
- Total Pages
  138
- Publisher
  The Humana Press
- ISBN
  9781489976918
- Data Source
  KAKENHI-PROJECT-17K09508
[Book] 中枢性血圧調節機構　「Annual Review 循環器 2016」（分担執筆）2016
- Author(s)
  廣岡良隆
- Total Pages
  286
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-24390198
[Book] Annual Review循環器20162016
- Author(s)
  廣岡　良隆
- Total Pages
  280
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-24390198
[Book] 血圧変動　エビデンス＆プラクティス2016
- Author(s)
  廣岡　良隆
- Total Pages
  215
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-24390198
[Book] 治療抵抗性高血圧に腎デナベーションは有効ではないのか？（SYMPLICITY IIIを受けて）．「EBM循環器疾患の治療　2015-2016」（分担執筆）2015
- Author(s)
  廣岡良隆
- Total Pages
  468
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-24390198
[Book] 二次性高血圧「高血圧診療Q&A 155」2014
- Author(s)
  廣岡良隆
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-24390198
[Book] Central and peripheral nervous system in “Nitric Oxide Synthase Inhibitors: From Animal Studies to Clinical Implications”, edited by Tunctan B.2013
- Author(s)
  Hirooka Y
- Total Pages
  286
- Publisher
  Transworld Research Network
- Data Source
  KAKENHI-PROJECT-24390198
[Book] Nitric Oxide Synthase Inhibitors : From Animal Studies to Clinical Implications2012
- Author(s)
  Hirooka Y
- Total Pages
  661
- Publisher
  Transworld Research Network(Central and peripheral nervous system)
- Data Source
  KAKENHI-PROJECT-24390198
[Book] II.血圧はどのように調節されているのか、どうして高血圧になるのか,中枢神経系・自律神経系調節「最新高血圧診療学」2010
- Author(s)
  廣岡良隆
- Publisher
  永井書店
- Data Source
  KAKENHI-PROJECT-19390231
[Book] 高血圧診療学(中枢神経系・自律神経系調節)2010
- Author(s)
  廣岡良隆
- Publisher
  永井書店
- Data Source
  KAKENHI-PROJECT-19390231
[Book] 高血圧における酸化ストレスとβ遮断薬「β遮断薬の全て:第3版」2009
- Author(s)
  伊藤浩司, 廣岡良隆
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-19390231
[Book] 高血圧における酸化ストレスとβ遮断薬「β遮断薬の全て : 第3版」2009
- Author(s)
  伊藤浩司, 廣岡良隆
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-19390231
[Book] Central Mechanisms of Cardiovascular Regulation(Role of nitric oxide and oxidative stress in the brain stem in cardiovascular regulation) (Edited by Kubo T and Kuwaki T)2007
- Author(s)
  Hirooka Y
- Publisher
  Transworld Research Network, Kerala, India(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590745
[Book] Role of nitric oxide and oxidative stress in the brainstem in cardiovascular regulation in "Central Mechanisms Cardiovascular Regulation"2007
- Author(s)
  Hirooka Y
- Publisher
  Transworld Research Network
- Data Source
  KAKENHI-PROJECT-19390231
[Book] 酸化ストレスと交感神経「酸化ストレスと心血管病」(横山光宏、藤田敏郎(編))2007
- Author(s)
  廣岡良隆
- Publisher
  日本医学出版
- Data Source
  KAKENHI-PROJECT-17590745
[Book] 5.神経体液性因子から知る3)交感神経はいかに働くか(筒井裕之(編)):「新・心臓病診療プラクティス6」心不全に挑む・患者を救う2005
- Author(s)
  廣岡良隆, 砂川賢二
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-17590745
[Book] アンジオテンシンIIと交感神経系(藤田敏郎(編)):ARBの新しい展開-臓器保護と降圧効果-2005
- Author(s)
  廣岡良隆
- Publisher
  日本医学出版
- Data Source
  KAKENHI-PROJECT-17590745
[Book] 交感神経抑制薬の展望(松尾壽之(編)):臨床分子内分泌学(2)-心血管内分泌代謝系(下)-2005
- Author(s)
  廣岡良隆, 下川宏明
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-17590745
[Book] Methods in Molecular Biology2004
- Author(s)
  Hirooka Y, Sakai K.
- Total Pages
  14
- Data Source
  KAKENHI-PROJECT-15590757
[Book] Methods in Molecular Biology2004
- Author(s)
  Hirooka Y, Sakai K.
- Total Pages
  14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590757
[Book] 抗酸化作用(荒川規矩(編)):高血圧-最新の研究動向-(上)
- Author(s)
  廣岡良隆, 砂川賢二
- Publisher
  日本臨牀社(印刷中)
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Age distribution and disease severity of COVID-19 patients continued to change in a time-dependent manner from May 2021 to April 2022 in the regional core hospital in Japan2023
- Author(s)
  Kawaura Futoshi、Kishi Takuya、Yamamoto Tadashi、Nakayama Shiki、Goto Taku、Tsurusawa Reimi、Katagiri Toshio、Yamanouchi Kohei、Matsuo Ayako、Kobayashi-Watanabe Naomi、Imamura Tomohiro、Hirooka Yoshitaka、Takagi Kuniyasu、Umemura Tsukuru、Fujimoto Kazuma、Hayashi Shinichiro、Takamori Ayako
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 17 Issue: 1 Pages: 60-65
- DOI
  10.5582/ddt.2022.01111
- ISSN
  1881-7831, 1881-784X
- Year and Date
  2023-02-28
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08431
[Journal Article] A Retrospective Analysis of Risk Factors for Mortality during Hemodialysis at a General Hospital That Treats Comprehensive Diseases2023
- Author(s)
  Kitajima Akira、Kishi Takuya、Yamanouchi Kohei、Hirooka Yoshitaka、Toda Shuji、Takamori Ayako、Fujimoto Kazuma、Kishi Chie、Tomiyoshi Yoshiyuki
- Journal Title
  
  Intern. Med.
  
  Volume: 62 Issue: 8 Pages: 1117-1121
- DOI
  10.2169/internalmedicine.0040-22
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2023-04-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08431
[Journal Article] A Case of Spreading Retroperitoneal Fibrosis Effectively Treated with Steroid Therapy2023
- Author(s)
  Nakashima Fumiaki、Watanabe Tsukasa、Tomiyoshi Yoshiyuki、Ejima Kazuhisa、Ootsuka Takateru、Nojiri Junichi、Fujimoto Kazuma、Hirooka Yoshitaka
- Journal Title
  
  Int. Heart J.
  
  Volume: 64 Issue: 1 Pages: 109-113
- DOI
  10.1536/ihj.22-470
- ISSN
  1349-2365, 1349-3299
- Year and Date
  2023-03-31
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08431
[Journal Article] The Effects of Physical Activity Intensity, Blood Pressure, and Body Fat Percentage on Vascular Endothelial Function in Male University Students2022
- Author(s)
  濵地望、岡真一郎、森田正治、廣岡良隆
- Journal Title
  
  Physical Therapy Japan
  
  Volume: 49 Issue: 2 Pages: 124-130
- DOI
  10.15063/rigaku.12199
- NAID
  130008161862
- ISSN
  0289-3770, 2189-602X
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08431
[Journal Article] Transient receptor potential vanilloid 1-expressing cardiac afferent nerves may contribute to cardiac hypertrophy in accompany with an increased expression of brain-derived neurotrophic factor within nucleus tractus solitarius in a pressure overload model2022
- Author(s)
  Shibata Risa、Shinohara Keisuke、Ikeda Shota、Iyonaga Takeshi、Matsuura Taku、Kashihara Soichiro、Ito Koji、Kishi Takuya、Hirooka Yoshitaka、Tsutsui Hiroyuki
- Journal Title
  
  Clinical and Experimental Hypertension
  
  Volume: 44 Issue: 3 Pages: 249-257
- DOI
  10.1080/10641963.2022.2029470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08431
[Journal Article] Carpal tunnel syndrome as an early red-flag sign of ATTRwt amyloidosis2021
- Author(s)
  Maeda-Ogata S, Tahara N, Bekki M, Tahara A, Sugiyama Y, Honda A, Igata S, Abe T, Ueda M, Ando Y, Hirooka Y, Fukumoto Y.
- Journal Title
  
  J Nucl Cardiol
  
  Volume: ー Issue: 6 Pages: 3562-3563
- DOI
  10.1007/s12350-021-02584-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03565, KAKENHI-PROJECT-20K08431, KAKENHI-PROJECT-23K24245
[Journal Article] Serum High-Sensitivity C-Reactive Protein Levels and the Development of Atrial Fibrillation in a General Japanese Population　― The Hisayama Study ―2021
- Author(s)
  Yoshikawa Tomoko、Hata Jun、Sakata Satoko、Nagata Takuya、Hirakawa Yoichiro、Hirooka Yoshitaka、Tsutsui Hiroyuki、Kitazono Takanari、Ninomiya Toshiharu
- Journal Title
  
  Circ J
  
  Volume: 85 Issue: 8 Pages: 1365-1372
- DOI
  10.1253/circj.CJ-20-0751
- NAID
  130008066717
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2021-07-21
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10503, KAKENHI-PROJECT-20K08431
[Journal Article] Relationships between Vascular Endothelial Function and Physical Activity/Diastolic Blood Pressure in Male University Students2021
- Author(s)
  HAMACHI Nozomi、OKA Shinichiro、MORITA Masaharu、HIROOKA Yoshitaka
- Journal Title
  
  Rigakuryoho Kagaku
  
  Volume: 36 Issue: 2 Pages: 227-232
- DOI
  10.1589/rika.36.227
- NAID
  130008027770
- ISSN
  1341-1667, 2434-2807
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08431
[Journal Article] 高血圧の成因2020
- Author(s)
  廣岡良隆
- Journal Title
  
  日本臨牀
  
  Volume: 78 Pages: 197-203
- Data Source
  KAKENHI-PROJECT-20K08431
[Journal Article] 高血圧の成因2020
- Author(s)
  廣岡良隆
- Journal Title
  
  日本臨牀
  
  Volume: 78 Pages: 197-203
- Data Source
  KAKENHI-PROJECT-17K09508
[Journal Article] Sympathetic Activation in Hypertension: Importance of the Central Nervous System2020
- Author(s)
  Hirooka Yoshitaka
- Journal Title
  
  American Journal of Hypertension
  
  Volume: 33 Issue: 10 Pages: 914-926
- DOI
  10.1093/ajh/hpaa074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08431
[Journal Article] 高血圧における免疫系の役割2019
- Author(s)
  廣岡良隆
- Journal Title
  
  Medical Science Digest
  
  Volume: 45 Pages: 690-692
- Data Source
  KAKENHI-PROJECT-17K09508
[Journal Article] Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats via sympathetic activation2019
- Author(s)
  Iyonaga Takeshi、Shinohara Keisuke、Mastuura Taku、Hirooka Yoshitaka、Tsutsui Hiroyuki
- Journal Title
  
  Hypertension Research
  
  Volume: 43 Issue: 2 Pages: 99-110
- DOI
  10.1038/s41440-019-0333-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09508, KAKENHI-PROJECT-20K08431
[Journal Article] Hypoxia-inducible factor-1 α deletion in myeloid lineage attenuates hypoxia-induced pulmonary hypertension.2019
- Author(s)
  Kojima H, Tokunou T, Takahara Y, Sunagawa K, Hirooka Y, Ichiki T, Tsutsui H.
- Journal Title
  
  Physiological Reports
  
  Volume: 7 Issue: 7 Pages: e14025-e14025
- DOI
  10.14814/phy2.14025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09508, KAKENHI-PROJECT-18K08041
[Journal Article] Prior exposure to placental ischemia causes increased salt sensitivity of blood pressure via vasopressin production and secretion in postpartum rats.2019
- Author(s)
  Matsuura T, Shinohara K, Iyonaga T, Shibata R, Hirooka Y, Tsutsui H.
- Journal Title
  
  Journal of Hypertension
  
  Volume: in press Issue: 8 Pages: 1657-1667
- DOI
  10.1097/hjh.0000000000002091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09508
[Journal Article] Proteinase-activated Receptor 1 Antagonism Ameliorates Experimental Pulmonary Hypertension.2018
- Author(s)
  Kuwabara Y, Tanaka-Ishikawa M, Abe K, Hirano M, Hirooka Y, Tsutsui H, Sunagawa K, Hirano K.
- Journal Title
  
  Cardiovascular Research
  
  Volume: in press Issue: 8 Pages: 1357-1368
- DOI
  10.1093/cvr/cvy284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09508, KAKENHI-PROJECT-17K09591, KAKENHI-PROJECT-16K09518
[Journal Article] High central blood pressure is associated with incident cardiovascular events in treated hypertensives: the ABC-J II Study.2018
- Author(s)
  Eguchi K, Miyashita H, Takenaka T, Tabara Y, Tomiyama H, Dohi Y, Hashimoto J, Ohkubo T, Ohta Y, Hirooka Y, Kohara K, Ito S, Kawano Y, Sunagawa K, Takazawa K, Yamashina A, Shimada K.
- Journal Title
  
  Hypertension Research
  
  Volume: 41 Issue: 11 Pages: 947-956
- DOI
  10.1038/s41440-018-0075-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09508, KAKENHI-PROJECT-16K15419, KAKENHI-PROJECT-17H04123
[Journal Article] 高血圧・心不全における交感神経活性化及び機序解明の進歩2018
- Author(s)
  廣岡良隆
- Journal Title
  
  自律神経
  
  Volume: 55 Pages: 1-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09508
[Journal Article] 腎デナベーション．2018
- Author(s)
  廣岡良隆
- Journal Title
  
  Current Therapy
  
  Volume: 36 Pages: 77-81
- Data Source
  KAKENHI-PROJECT-17K09508
[Journal Article] Olemsartan combined with renal denervation reduces blood pressure in association with sympatho-inhibitory aned aldosterone-reducing effects in hypertensive mice with chronic kidney disease.2018
- Author(s)
  Nishihara M, Takesue K, Hirooka Y
- Journal Title
  
  Clinical and Experimental Hypertension
  
  Volume: 40 Issue: 3 Pages: 211-219
- DOI
  10.1080/10641963.2018.1465075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09508, KAKENHI-PROJECT-17K16010
[Journal Article] Activation of microglia within paraventricular nucleus of hypothalamus in NOT involved in maintenance of established hypertension.2017
- Author(s)
  Takesue K, Kishi T, Hirooka Y, Sunagawa K.
- Journal Title
  
  J Cardiol
  
  Volume: 69 Pages: 84-88
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390198
[Journal Article] Renal denervation enhances GABA-ergic input into the PVN leading to blood pressure lowering in chronic kidney disease.2017
- Author(s)
  Nishihara M, Takesue K, Hirooka Y.
- Journal Title
  
  Auton Neurosci
  
  Volume: 204 Pages: 88-97
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390198
[Journal Article] Arterial pressure　labiality　is　improved　by　sodium-glucose　cotransporter　2　inhibitor　in　streptozocin-induced diabetic rats.2017
- Author(s)
  Yoshikawa T, Kishi T, Sahinohara K, Takesue K, Shibata R, Inoguchi T, Sunagawa K, Tsutsui H, Hirooka Y.
- Journal Title
  
  Hypertens Res
  
  Volume: 印刷中 Issue: 7 Pages: 646-651
- DOI
  10.1038/hr.2017.14
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390198, KAKENHI-PROJECT-17K09508
[Journal Article] 拡張期血圧：その規定因子，下げかた，下げ過ぎの危険．2017
- Author(s)
  廣岡良隆
- Journal Title
  
  Medical Practice
  
  Volume: 34 Pages: 1295-1300
- Data Source
  KAKENHI-PROJECT-17K09508
[Journal Article] 本態性高血圧の成因としての交感神経系．2016
- Author(s)
  廣岡　良隆
- Journal Title
  
  血圧
  
  Volume: 26 Pages: 403-407
- Data Source
  KAKENHI-PROJECT-24390198
[Journal Article] 高血圧のカテーテル・デバイス治療の現状と未来．2016
- Author(s)
  廣岡　良隆
- Journal Title
  
  Pharama Medica
  
  Volume: 34 Pages: 47-52
- Data Source
  KAKENHI-PROJECT-24390198
[Journal Article] Haemodynamic unloading reverses occlusive vascular lesions in severe pulmonary hypertension.2016
- Author(s)
  Abe K, Shinoda M, Tanaka M, Kuwabara Y, Yoshida K, Hirooka Y, McMurtry IF, Oka M, Sunagawa K.
- Journal Title
  
  Cardiovasc Res.
  
  Volume: In Press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23220013
[Journal Article] Activation of microglia within paraventricular nucleus of hypothalamus is NOT involved in maintenance of established hypertension.2016
- Author(s)
  Takesue K, Kishi T, Hirooka Y, Sunagawa K.
- Journal Title
  
  J Cardiol.
  
  Volume: In Press Issue: 1 Pages: 84-88
- DOI
  10.1016/j.jjcc.2016.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24390198
[Journal Article] Decreased proportion of Foxp3+CD4+ regulatory T cells contributes to the development of hypertension in genetically hypertensive rats.2015
- Author(s)
  Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
- Journal Title
  
  Journal of Hypertension
  
  Volume: 33 Issue: 4 Pages: 773-783
- DOI
  10.1097/hjh.0000000000000469
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390198, KAKENHI-PROJECT-23220013
[Journal Article] Combining irbesartan and trichlormethiazide enhances blood pressure reduction via inhibition of sympathetic activity without adverse effects on metabolism in hypertensive rats with metabolic syndrome.2015
- Author(s)
  Nishihara M, Hirooka Y, Sunagawa K.
- Journal Title
  
  Clin Exp Hypertens.
  
  Volume: 37 Issue: 1 Pages: 33-38
- DOI
  10.3109/10641963.2014.897719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24390198
[Journal Article] Circulating angiotensin II deteriorates left ventricular function with sympathoexcitation via brain angiotensin II receptor.2015
- Author(s)
  Shinohara K, Kishi T, Hirooka Y, Sunagawa K.
- Journal Title
  
  Physiol Rep.
  
  Volume: 3 Issue: 8 Pages: e12514-e12514
- DOI
  10.14814/phy2.12514
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24390198
[Journal Article] Negative acute hemodynamic response to balloon pulmonary angioplasty does not predicate the long-term outcome in patients with chronic thromboembolic pulmonary hypertension.2015
- Author(s)
  Hosokawa K, Abe K, Oi K, Mukai Y, Hirooka Y, Sunagawa K.
- Journal Title
  
  International Journal of Cardiology
  
  Volume: 188 Pages: 81-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659393
[Journal Article] Brain Angiotensin II Type 1 Receptor Blockade Improves Dairy Blood Pressure Variability via Sympathoinhibition in Hypertensive Rats.2015
- Author(s)
  Kishi T, Hirooka Y, Sunagawa K.
- Journal Title
  
  Int J Hypertens.
  
  Volume: 2015 Pages: 759629-759629
- DOI
  10.1155/2015/759629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013
[Journal Article] Tropomyosin-Related Kinase B in Hippocampus of Obesity-Induced Hypertensive Rats2015
- Author(s)
  Kishi T, Hirooka Y, Nagayama T, Isegawa K, Katsuki M, Takesue K, Sunagawa K.
- Journal Title
  
  Int. Heart J.
  
  Volume: 56 Issue: 1 Pages: 110-115
- DOI
  10.1536/ihj.14-168
- NAID
  130004941290
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013
[Journal Article] Blockade of brain angiotensin II type 1 receptor inhibits the development of atrial fibrillation in hypertensive rats.2015
- Author(s)
  Nagayama T, Hirooka Y, Kishi T, Mukai Y, Inoue S, Takase S, Takemoto M, Chishaki A, Sunagawa K.
- Journal Title
  
  American Journal of Hypertension
  
  Volume: 28 Issue: 4 Pages: 444-451
- DOI
  10.1093/ajh/hpu196
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390198
[Journal Article] Cardiac sympathetic afferent stimulation induces salt-sensitive sympathoexcitation through hypothalamic epithelial Na+ channel activation.2015
- Author(s)
  Ito K, Hirooka Y, Sunagawa K
- Journal Title
  
  Am J Physiol Heart Circ Physiol
  
  Volume: 308 Issue: 5 Pages: H530-H539
- DOI
  10.1152/ajpheart.00586.2014
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461112, KAKENHI-PROJECT-23220013
[Journal Article] Duration of electrically induced atrial fibrillation is augmented by high voltage of stimulus with higher blood pressure in hypertensive rats.2014
- Author(s)
  Nagayama T, Hirooka Y, Chishaki A, Takemoto M, Mukai Y, Inoue S, Kishi T, Sunagawa K.
- Journal Title
  
  Int J Hypertens.
  
  Volume: 2014 Pages: 980505-980505
- DOI
  10.1155/2014/980505
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24390198, KAKENHI-PROJECT-26670957
[Journal Article] Telmisartan reduces mortality and left ventricular hypertrophy with sympathoinhibition in rats with hypertension and heart failure.2014
- Author(s)
  Kishi T, Hirooka Y, Sunagawa K.
- Journal Title
  
  Am J Hypertens.
  
  Volume: 27 Issue: 2 Pages: 260-267
- DOI
  10.1093/ajh/hpt188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24390198
[Journal Article] Benefit of azilsartan on blood pressure elevation around rest-to-active phase in spontaneously hypertensive rats.2014
- Author(s)
  Isegawa K, Hirooka Y, Kishi T, Yasukawa K, Utsumi H, Sunagawa K.
- Journal Title
  
  Clin Exp Hypertens.
  
  Volume: 37 Issue: 1 Pages: 45-50
- DOI
  10.3109/10641963.2014.897721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24390198
[Journal Article] Combining irbesartan and trichlormethiazide enhances blood pressure reduction via inhibition of sympathetic activity without adverse effects on metabolism in hypertensive rats with metabolic syndrome.2014
- Author(s)
  Nishihara M, Hirooka Y, Sunagawa K.
- Journal Title
  
  Clin Exp Hypertens
  
  Volume: In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013
[Journal Article] 今後期待される肺高血圧症治療薬の展望．2014
- Author(s)
  阿部弘太郎、廣岡良隆、砂川賢二
- Journal Title
  
  呼吸器内科
  
  Volume: 26 Pages: 300-304
- NAID
  40020251438
- Data Source
  KAKENHI-PROJECT-24659393
[Journal Article] Central neuregulin-1/ErbB signaling modulates cardiac function via sympathetic activity in pressure overload-induced heart failure2014
- Author(s)
  Matsukawa R, Hirooka Y, Ito K, Honda N, Sunagawa K.
- Journal Title
  
  J Hypertens.
  
  Volume: 32 Issue: 4 Pages: 817-825
- DOI
  10.1097/hjh.0000000000000072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013
[Journal Article] Angiotensin II type 1 receptor expression in astrocytes is upregulated leading to increased mortality in mice with myocardial infarction-induced heart failure.2014
- Author(s)
  Isegawa K, Hirooka Y, Katsuki M, Kishi T, Sunagawa K.
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 307 Issue: 10 Pages: H1448-H1455
- DOI
  10.1152/ajpheart.00462.2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24390198, KAKENHI-PROJECT-24591058
[Journal Article] Corticosterone-activated mineralocorticoid receptor contributes to salt-induced sympathoexcitation in pressure overload mice.2014
- Author(s)
  Ito K, Hirooka Y, Sunagawa K.
- Journal Title
  
  Clin Exp Hypertens.
  
  Volume: 36 Issue: 8 Pages: 550-556
- DOI
  10.3109/10641963.2014.881841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24390198
[Journal Article] Novel dual endothelin receptor antagonist macitentan reverses severe pulmonary arterial hypertension in rats.2014
- Author(s)
  Kunita-Takanezawa M, Abe K, Hirooka Y, Kuwabara Y, Hirano K, Oka M, Sunagawa K.
- Journal Title
  
  J Cardiovasc Pharmacol.
  
  Volume: 64 Issue: 5 Pages: 473-80
- DOI
  10.1097/fjc.0000000000000141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24659393, KAKENHI-PROJECT-26461146
[Journal Article] Central neuregulin-1/ErbB signaling modulates cardiac function via sympathetic activity in pressure overload-induced heart failure.2014
- Author(s)
  Matsukawa R, Hirooka Y, Ito K,　Honda N, Sunagawa K.
- Journal Title
  
  Journal of Hypertension
  
  Volume: 32 Pages: 817-825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390198
[Journal Article] Partially silencing brain toll-like receptor 4 prevents in part left ventricular remodeling with sympathoinhibition in rats with myocardial infarction-induced heart failure.2013
- Author(s)
  Ogawa K, Hirooka Y, Kishi T, Ide T, Sunagawa K.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 7 Pages: e69053-e69053
- DOI
  10.1371/journal.pone.0069053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24390198
[Journal Article] Mineralocorticoid receptors/epithelial Na(+) channels in the choroid plexus are involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats.2013
- Author(s)
  Nakano M, Hirooka Y, Matsukawa R, Ito K, Sunagawa K.
- Journal Title
  
  Hypertens Res.
  
  Volume: 36 Issue: 3 Pages: 277-284
- DOI
  10.1038/hr.2012.174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24390198
[Journal Article] Potential clinical application of recently discovered brain mechanisms involved in hypertension.2013
- Author(s)
  Hirooka Y, Kishi T, Ito K, Sunagawa K.
- Journal Title
  
  Hypertension
  
  Volume: 62 Pages: 995-1002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390198
[Journal Article] 特発性肺動脈性肺高血圧症はどんな病気2013
- Author(s)
  阿部弘太郎、廣岡良隆、砂川賢二
- Journal Title
  
  Heart View
  
  Volume: 17 Pages: 24-29
- Data Source
  KAKENHI-PROJECT-24659393
[Journal Article] Brain sigma-1 receptor stimulation improves mental disorder and cardiac function in mice with myocardial infarction.2013
- Author(s)
  Ito K, Hirooka Y, Sunagawa K.
- Journal Title
  
  J Cardiovasc Pharmacol.
  
  Volume: 62 Issue: 2 Pages: 222-228
- DOI
  10.1097/fjc.0b013e3182970b15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013
[Journal Article] Moxonidine-induced central sympathoinhibition improves prognosis in rats with hypertensive heart failure.2013
- Author(s)
  Honda N, Hirooka Y, Ito K, Matsukawa R, Shinohara K, Kishi T, Yasukawa K, Utsumi H, Sunagawa K.
- Journal Title
  
  J Hypertens
  
  Volume: 31 Issue: 11 Pages: 2300-2308
- DOI
  10.1097/hjh.0b013e328364a2a1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24390198, KAKENHI-PROJECT-25253005
[Journal Article] Role of hypothalamic angiotensin type 1 receptors in pressure overload-induced mineralocorticoid receptor activation and salt-induced sympathoexcitation.2013
- Author(s)
  Ito K, Hirooka Y, Nakano M, Honda N, Matsukawa R, Sunagawa K.
- Journal Title
  
  Hypertens Res.
  
  Volume: 36 Issue: 6 Pages: 513-519
- DOI
  10.1038/hr.2012.221
- NAID
  10031189655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24390198
[Journal Article] Inhibition of neuregulin-1/ErbB signaling in the rostral ventrolateral medulla leads to hypertension through reduced nitric oxide synthesis.2013
- Author(s)
  Matsukawa R, Hirooka Y, Ito K, Sunagawa K.
- Journal Title
  
  Am J Hypertens
  
  Volume: 26 Issue: 1 Pages: 51-57
- DOI
  10.1093/ajh/hps005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24390198
[Journal Article] チロシンキナーゼ阻害薬の肺高血圧症治療薬としての展望2013
- Author(s)
  阿部弘太郎、廣岡良隆、砂川賢二
- Journal Title
  
  循環器内科
  
  Volume: 74 Pages: 615-619
- NAID
  40019933697
- Data Source
  KAKENHI-PROJECT-24659393
[Journal Article] 肺高血圧症の成因2013
- Author(s)
  阿部弘太郎、廣岡良隆、砂川賢二
- Journal Title
  
  呼吸と循環
  
  Volume: 61 Pages: 1097-1103
- Data Source
  KAKENHI-PROJECT-24659393
[Journal Article] Potential clinical application of recently discovered brain mechanisms involved in hypertension.2013
- Author(s)
  Hirooka Y, Kishi T, Ito K, Sunagawa K.
- Journal Title
  
  Hypertension.
  
  Volume: 62 Issue: 6 Pages: 995-1002
- DOI
  10.1161/hypertensionaha.113.00801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013
[Journal Article] Combination therapy of olmesartan and azelnidipine inhibits sympathetic activity associated with reducing oxidative stress in the brain of hypertensive rats.2012
- Author(s)
  Shinohara K, Hirooka Y, Ogawa K, Kishi T, Yasukawa K, Utsumi H, Sunagawa K.
- Journal Title
  
  Clin Exp Hypertens
  
  Volume: 34(6) Issue: 6 Pages: 456-62
- DOI
  10.3109/10641963.2012.666603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003, KAKENHI-PROJECT-23220013
[Journal Article] Reduction of Nitric Oxide-Mediated γ-Amino Butyric Acid Release in Rostral Ventrolateral Medulla Is Involved in Superoxide-Induced Sympathoexcitation of Hypertensive Rats2012
- Author(s)
  Shinohara K, Hirooka Y, et al.
- Journal Title
  
  Circ J
  
  Volume: 76 Issue: 12 Pages: 2814-2821
- DOI
  10.1253/circj.CJ-12-0399
- NAID
  10031126053
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390198
[Journal Article] Central mechanisms of abnormal sympathoexcitation in chronic heart failure2012
- Author(s)
  Kishi T, Hirooka Y, et al.
- Journal Title
  
  Cardiovascular Research and Practice
  
  Volume: 2012 Pages: 847172-847172
- DOI
  10.1155/2012/847172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390198
[Journal Article] Oxidative stress in the rostral ventrolateral medulla modulates excitatory and inhibitory inputs in spontaneously hypertensive rats.2012
- Author(s)
  Nishihara M, Hirooka Y, Matsukawa R, Kishi T, Sunagawa K.
- Journal Title
  
  J Hypertens
  
  Volume: 30(1) Issue: 1 Pages: 97-106
- DOI
  10.1097/hjh.0b013e32834e1df4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003, KAKENHI-PROJECT-23220013
[Journal Article] Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension.2011
- Author(s)
  Hirooka Y, et al.
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol
  
  Volume: 300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension.2011
- Author(s)
  Hirooka Y., et al
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol
  
  Volume: 300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension2011
- Author(s)
  Hirooka Y, et al
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol.
  
  Volume: 300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18100006
[Journal Article] Oxidative stress in the cardiovascular center has a pivotal role in the sympathetic activation in hypertension.2011
- Author(s)
  Hirooka Y.
- Journal Title
  
  Hypertens Res 34
  
  Pages: 407-412
- NAID
  10031163191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Oxidative stress in the cazdiovascular center has a pivotal role in the sympathetic activation in hypertension.2011
- Author(s)
  Hirooka Y
- Journal Title
  
  Hypertension Research
  
  Volume: 34(In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Caloric restriction inhibits sympathetic nerve activity via anti-oxidant effect in the rostral ventrolateral medulla of obesity-induced hypertensive rats.2011
- Author(s)
  Kishi T, Hirooka Y, et al
- Journal Title
  
  Clin Exp Hypertens (in press).
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension.2011
- Author(s)
  Hirooka Y, Kishi T, Sakai K, Takeshita A, Sunagawa K.
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol. 300
- Data Source
  KAKENHI-PROJECT-18100006
[Journal Article] Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension2011
- Author(s)
  Hirooka Y, et al
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol
  
  Volume: 300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013
[Journal Article] Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension2011
- Author(s)
  Hirooka Y, Kishi T, Sakai K, Takeshita A, Sunagawa K.,
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol.
  
  Volume: 300 Issue: 4 Pages: R818-R826
- DOI
  10.1152/ajpregu.00426.2010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension.2011
- Author(s)
  Hirooka Y, Kishi T, et al
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol 300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Blockade of mineralocorticoid receptors improves salt-induced left-ventricular systolic dysfunction through attenuation of enhanced sympathetic drive in mice with pressure overload.2010
- Author(s)
  Ito K, Hirooka Y, Sunagawa K.
- Journal Title
  
  J Hypertens. 28
  
  Pages: 1449-1458
- Data Source
  KAKENHI-PROJECT-18100006
[Journal Article] Blockade of mineralocorticoid receptors improves salt-induced left-ventricular systolic dysfunction through attenuation of enhanced sympathetic drive in mice with pressure overload.2010
- Author(s)
  Ito K, Hirooka Y, Sunagawa K.
- Journal Title
  
  J Hypertens 28
  
  Pages: 1449-1458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Angiotensin II type 1 receptor-activated caspase-3 through ras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats2010
- Author(s)
  Kishi T, Hirooka Y, et al(3名・2番目)
- Journal Title
  
  Hypertension 55
  
  Pages: 291-297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Angiotensin II type 1 receptor-activated caspase-3 through ras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats.2010
- Author(s)
  Kishi T, Hirooka Y, Konno S, Ogawa K, Sunagawa K.
- Journal Title
  
  Hypertension. 55
  
  Pages: 291-297
- Data Source
  KAKENHI-PROJECT-18100006
[Journal Article] Oxidative stress and central cardiovascular regulation-Pathogenesis of hypertension and therapeutic aspects-.2010
- Author(s)
  Hirooka Y, Kishi T, et al
- Journal Title
  
  Circ J 74
  
  Pages: 827-835
- NAID
  10026473063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Blockade of mineralocorticoid receptors improves salt-induced left-ventricular systolic dysfunction through attenuation of enhanced sympathetic drive in mice with pressure overload.2010
- Author(s)
  Ito K, Hirooka Y, Sunagawa K
- Journal Title
  
  J Hypertens.
  
  Volume: 28 Pages: 1449-1458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18100006
[Journal Article] Sympathoinhibition induced by centrally administered atorvastatin is associated with alteration of NAD(P)H and Mn superoxide dismutase activity in rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats2010
- Author(s)
  Kishi T, Hirooka Y, et al(2名・2番目)
- Journal Title
  
  J Cardiovasc Pharmacol 55
  
  Pages: 184-190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Oxidative stress and central cardiovascular regulation.-Pathogenesis of hypertension and therapeutic aspects.2010
- Author(s)
  Hirooka Y, et al
- Journal Title
  
  Circ J
  
  Volume: 74 Pages: 827-835
- NAID
  10026473063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18100006
[Journal Article] Sympathoinhibition induced by centrally administered atorvastatin is associated with alteration of NAD(P)H oxidase and Mn superoxide dismutase activity in rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.2010
- Author(s)
  Kishi T, Hirooka Y, et al
- Journal Title
  
  J Cardiovasc Pharmacol 55
  
  Pages: 184-190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Angiotensin II type 1 receptor-activated caspase-3 through ras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats.2010
- Author(s)
  Kishi T, Hirooka Y, et al
- Journal Title
  
  Hypertension 55
  
  Pages: 291-297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Olmesartan reduces oxidative stress in the brain of stroke-prone spontaneously hypertensive rats assessed by an in vivo ESR method2009
- Author(s)
  Hirooka Y, Kishi T, Utsumi H, et al(3名・2番目)
- Journal Title
  
  Hypertens Res 32
  
  Pages: 1091-1096
- NAID
  10026124882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Role of inducible nitric oxide synthase in rostral ventrolateral medulla in blood pressure regulation in spontaneously hypertensive rats.2009
- Author(s)
  Kimura Y, Hirooka Y, Kishi T, et al
- Journal Title
  
  Clin Exp Hypertens 31
  
  Pages: 281-286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Acquisition of Brain Na Sensitivity Contributes to Salt-Induced Sympathoexcitation and Cardiac Dysfunction in Mice With Pressure Overload.2009
- Author(s)
  Ito K, Hirooka Y, Sunagawa K.
- Journal Title
  
  Circ Res. 104
  
  Pages: 1004-1011
- Data Source
  KAKENHI-PROJECT-18100006
[Journal Article] Acquisition of Brain Na Sensitivity Contributes to Salt-Induced Sympathoexcitation and Cardiac Dysfunction in Mice With Pressure Overload2009
- Author(s)
  Ito K, Hirooka Y, Sunagawa K.
- Journal Title
  
  Circ Res (In press)
- Data Source
  KAKENHI-PROJECT-18100006
[Journal Article] Acquisition of brain Na sensitivity contributes to salt-induced sympathoexcitation and cardiac dysfunction in mice with pressure overload.2009
- Author(s)
  Ito K, Hirooka Y, Sunagawa K.
- Journal Title
  
  Circ Res 104
  
  Pages: 1004-1011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Olmesartan reduces oxidative stress in the brain of stroke-prone spontaneously hypertensive rats assessed by an in vivo ESR method.2009
- Author(s)
  Araki S, Hirooka Y, Kishi T, Utsumi H, et al
- Journal Title
  
  Hypertens Res 32
  
  Pages: 1091-1096
- NAID
  10026124882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Cilnidipine inhibits the sympathetic nerve activity and improves baroreflex sensitivity in patients with hypertension.2009
- Author(s)
  Kishi T, Hirooka Y, et al
- Journal Title
  
  Clin Exp Hypertens 31
  
  Pages: 241-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction.2008
- Author(s)
  Tsutsumi T, Ide T, Yamato M, Kudou W, Andou M, Hirooka Y, Utsumi H, Tsutsui H, Sunagawa K.
- Journal Title
  
  Cardiovasc Res. 77
  
  Pages: 713-721
- Data Source
  KAKENHI-PROJECT-18100006
[Journal Article] High salt intake enhances blood pressure increase during development of hypertension via oxidative stress in rostral ventrolateral medulla of spontaneously hypertensive rats2008
- Author(s)
  Hirooka Y, Kishi T, et al(4名・2番目)
- Journal Title
  
  Hypertens Res 31
  
  Pages: 2075-2083
- NAID
  10024828267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Effects of valsartan or amlodipine on endothelial function and oxidative stress after one year follow-up in patients with essential hypertension.2008
- Author(s)
  Hirooka Y, et al
- Journal Title
  
  Clin Exp Hypertens. 30
  
  Pages: 267-276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18100006
[Journal Article] Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction2008
- Author(s)
  Tsutsumi T, Ide T, Yamato M, Kudou W, Andou M, Hirooka Y, Utsumi H, Tsutsui H, Sunagawa K.
- Journal Title
  
  Cardiovasc Res. 77
  
  Pages: 713-721
- Data Source
  KAKENHI-PROJECT-18100006
[Journal Article] Mitochondria-derived reactive oxygen species mediate sympathoexcitation induced by angiotensin II in the rostarl ventrolateral medulla2008
- Author(s)
  Hirooka Y, Kishi T, Ide T, et al(5名・2番目)
- Journal Title
  
  J Hypertens 26
  
  Pages: 2176-2184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] High salt intake enhances blood pressure increase during development of hypertension via oxidative stress in rostarl ventrolateral medulla of spontaneously hypertensive rats.2008
- Author(s)
  Koga Y, Hirooka Y, Kishi T, et al
- Journal Title
  
  Hypertens Res 31
  
  Pages: 2075-2083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Azelnidipine decreases sympathetic nerve activity via antioxidant effect in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.2008
- Author(s)
  Konno S, Hirooka Y, Kishi T, et al
- Journal Title
  
  J Cardiovasc Pharmacol 52
  
  Pages: 555-560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Mitochondria-derived reactive oxygen species mediate sympathoexcitation induced by angiotensin II in the rostral ventrolateral medulla.2008
- Author(s)
  Nozoe M, Hirooka Y, Kishi T, Ide T, et al.
- Journal Title
  
  J Hypertens 26
  
  Pages: 2176-2184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Atorvastatin reduces oxidative stress in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats2008
- Author(s)
  Kishi T, Hirooka Y, Shimokawa H, Takeshita A, Sunaeawa K
- Journal Title
  
  Clinical and Experimental Hypertension 33
  
  Pages: 3-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Role of reactive oxygen species in brainstem in neural mechanisms of hypertension.2008
- Author(s)
  Hirooka Y.
- Journal Title
  
  Auton Neurosci 142
  
  Pages: 20-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Inhibition of Racl-derived reactive oxygen species in nucleus tractus solitarius decreases blood pressure and heart rate in stroke-pronespontaneously hypertensive rats2007
- Author(s)
  Nozoe M, Hirooka Y, Koga Y, Kishi T, Engelhardt JF, Sunagawa K
- Journal Title
  
  Hypertension 50
  
  Pages: 62-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Pressor response induced by central angiotensin II is mediated by activation of Rho/Rho-kinase pathway via ATI receptors.2007
- Author(s)
  Sagara Y, Hirooka Y, (他4名)
- Journal Title
  
  Journal of Hypertension 25(2)
  
  Pages: 399-406
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Role of nitric oxide and oxidative stress in the brain stem in cardiovascular regulation2007
- Author(s)
  Hirooka Y.
- Journal Title
  
  Central Mechanisms of Cardiovascular Regulation(Edited by Kubo T and Kuwaki T)(Transworld Research Network, Kerala, India) (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Inhibition of Racl-derived reactive oxygen species in nucleus tractus solitarius decreases blood pressure and heart rate in stroke-prone spontaneously hypertensive rats.2007
- Author(s)
  Nozoe M, Hirooka Y, Koga Y, Sagara Y, Kishi T, Engelhardt JF, Sunagawa K.
- Journal Title
  
  Hypertension. 50 (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Pressor response induced by central angiotensin II is mediated by activation of Rho/Rho-kinase pathway via AT1 receptors.2007
- Author(s)
  Sagara Y, Hirooka Y, Nozoe M, Ito K, Kimura Y, Sunagawa K.
- Journal Title
  
  Journal of Hypertension. 25(2)
  
  Pages: 399-406
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Inhibition of Racl-derived reactive oxygen species in nucleus tractus solitarius decreases blood pressure and heart rate in stroke-prone spontaneously hypertensive rats.2007
- Author(s)
  Nozoe M, Hirooka Y, (他5名)
- Journal Title
  
  Hypertension 50(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Pressor response induced by central angiotensin II is mediated by activation of Rho/Rho-kinase pathway via AT1 receptors.2007
- Author(s)
  Sagara Y, Hirooka Y, (他4名)
- Journal Title
  
  Journal of Hypertension 25(2)
  
  Pages: 399-406
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Role of nitric oxide and oxidative stress2007
- Author(s)
  Hirooka Y
- Journal Title
  
  the brainstem in cardiovascularregulation in"Central Mechanisms of Cardiovascular Regulation", Transworld Research Network
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Long-acting calcium channel blocker, azelnidipine, increases endothelial nitric oxide synthase in the brain and inhibits sympathetic nerve activity.2007
- Author(s)
  Kimura Y, Hirooka Y, Sagara Y, Sunagawa K.
- Journal Title
  
  Clinical and Experimental Hypertension. 29(1)
  
  Pages: 13-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Transworld Research Network, Kerala, India (図書、出版社です)2007
- Author(s)
  Hirooka Y
- Journal Title
  
  Role of nitric oxide and oxidative stress in the brain stem in cardiovascular regulation 「 Central Mechani sms of Cardiovascular Regulation」 Edited by Kubo T and Kuwaki T (In press)
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Long-acting calcium channel blocker, azelnidipine, increases endothelial nitric oxide synthase in the brain and inhibits sympathetic nerve activity.2007
- Author(s)
  Kimura Y, Hirooka Y, (他2名)
- Journal Title
  
  Clinical and Experimental Hypertension 29(1)
  
  Pages: 13-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Amlodipine-induced reduction of oxidative stress in the brain is associated with sympatho-inhibitory effects in stroke-prone spontaneously hypertensive rats.2006
- Author(s)
  Hirooka Y, Kimura Y, Nozoe M, Sagara Y, Ito K, Sunagawa K.
- Journal Title
  
  Hypertens Res. 29
  
  Pages: 49-56
- NAID
  10018060825
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Localized gene transfer and its application for the study of central cardiovascular control.2006
- Author(s)
  Hirooka Y.
- Journal Title
  
  Autonomic Neuroscience : Basic and Clinical. 126-127
  
  Pages: 120-129
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Ovariectomy augments hypertension through Rho-kinase activation in the brain in female spontaneously hypertensive rats.2006
- Author(s)
  Ito K, Hirooka Y, Kimura Y, Sagara Y, Sunagawa K.
- Journal Title
  
  Hypertension. 48(4)
  
  Pages: 651-657
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Amlodipine-induced reduction of oxidative stress in the brain is associated with sympatho-inhibitory effects in stroke-prone spontaneously hypertensive rats.2006
- Author(s)
  Hirooka Y, (他5名)
- Journal Title
  
  Hypertension Research 29(1)
  
  Pages: 49-56
- NAID
  10018060825
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Localized gene transfer and its application for the study of central cardiovascular control.2006
- Author(s)
  Hirooka Y
- Journal Title
  
  Autonomic Neuroscience : Basic and Clinical 126-127
  
  Pages: 120-129
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Ovariectomy augments hypertension through Rho-kinase activation in the brain in female spontaneously hypertensive rats.2006
- Author(s)
  Ito K, Hirooka Y, (他3名)
- Journal Title
  
  Hypertension 48(4)
  
  Pages: 651-657
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase hi oxidative stress.2005
- Author(s)
  Kimura Y, Hirooka Y et al.
- Journal Title
  
  Circulation Research 96
  
  Pages: 252-260
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590757
[Journal Article] 高血圧症の標的臓器障害と交感神経活動交感神経系による血圧調節-最近の進歩-2005
- Author(s)
  廣岡良隆
- Journal Title
  
  血圧 12
  
  Pages: 60-64
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress.2005
- Author(s)
  Kimura Y, Hirooka Y et al.
- Journal Title
  
  Circulation Research 96
  
  Pages: 252-260
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590757
[Journal Article] Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition.2004
- Author(s)
  Ito K, Hirooka Y et al.
- Journal Title
  
  Hypertension 43
  
  Pages: 156-162
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590757
[Journal Article] Inhibition of Rho-kinase in the brainstem augments baroreflex control of heart rate in rats.2004
- Author(s)
  Ito K, Hirooka Y et al.
- Journal Title
  
  Hypertension 44
  
  Pages: 478-483
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590757
[Journal Article] Adenovirus-mediated gene transfer into the brain stem to examine cardiovascular function : Role of nitric oxide and Rhokinase.2004
- Author(s)
  Hirooka Y
- Journal Title
  
  Progress in Biophysics and Molecular Biology 84
  
  Pages: 23-249
- Data Source
  KAKENHI-PROJECT-15590757
[Journal Article] Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats.2004
- Author(s)
  Kishi T, Hirooka Y et al.
- Journal Title
  
  Circulation 109
  
  Pages: 2357-2362
- NAID
  110002708842
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590757
[Journal Article] Adenovirus-mediated gene transfer into the brain stem to examine cardiovascular function : Role of nitric oxide and Rho-kinase.2004
- Author(s)
  Hirooka Y
- Journal Title
  
  Progress in Biophysics and Molecular Biology 84
  
  Pages: 233-249
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590757
[Journal Article] Adenovirus-mediated gene transfer into the brain stem to examine cardiovascular function : Role of nitric oxide and Rho-kinase.2004
- Author(s)
  Hirooka Y.
- Journal Title
  
  Progress in Biophysics and Molecular Biology 84
  
  Pages: 233-249
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590757
[Journal Article] Adenovirus-mediated nitric oxide synthase gene transfer into the nucleus tractus solitarius in conscious rats.2004
- Author(s)
  Hirooka Y, Sakai K.
- Journal Title
  
  Methods in Molecular Biology 279
  
  Pages: 187-200
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590757
[Journal Article] Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system : possible involvement in neural mechanisms of hypertension.2003
- Author(s)
  Ito K, Hirooka Y et al.
- Journal Title
  
  Circulation Research 92
  
  Pages: 1337-1343
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590757
[Journal Article] Localized gene transfer and its application for the study of central cardiovascular control.
- Author(s)
  Hirooka Y.
- Journal Title
  
  Autonomic Neuroscience : Basic and Clinical. (in press)
- Data Source
  KAKENHI-PROJECT-17590745
[Journal Article] Amlodipine-induced reduction of oxidative stress in the brain is associated with sympatho-inhibitory effects in stroke-prone spontaneously hypertensive rats.
- Author(s)
  Hirooka Y, Kimura Y, Nozoe M, Sagara Y, Ito K, Sunagawa K.
- Journal Title
  
  Hypertension Research. 29(1)
- NAID
  10018060825
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590745
[Presentation] 高血圧患者におけるmiRNA-21と心不全指標との関連．2022
- Author(s)
  西之園栞、安田聖子、廣岡良隆
- Organizer
  第26回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08431
[Presentation] Role of the sympathetic nervous system in hypertension: focused on the central nervous system.2022
- Author(s)
  Yoshitaka Hirooka
- Organizer
  International Society of Hypertension 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08431
[Presentation] 将来的な心不全バロメーターである血管内皮機能検査を実施した若年男性の特徴．2022
- Author(s)
  濱地望，廣岡良隆
- Organizer
  第26回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08431
[Presentation] 高血圧患者におけるmicroRNAと心不全関連指標との関連．2022
- Author(s)
  西之園栞、安田聖子、廣岡良隆
- Organizer
  第44回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-20K08431
[Presentation] Role of the sympathetic nervous system in hypertension: focused on the central nervous system.2022
- Author(s)
  Yoshitaka Hirooka
- Organizer
  The 20th International SHR Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08431
[Presentation] 高血圧患者における血管内皮機能への影響因子：年齢・性別で区別した評価．2021
- Author(s)
  西之園栞、安田聖子、廣岡良隆．
- Organizer
  第43回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-20K08431
[Presentation] 心不全バロメーターとしての血管内皮機能に対する身体活動要因の影響：若年健常男性での検討．2021
- Author(s)
  濱地望，岡真一郎，森田正治，廣岡良隆．
- Organizer
  第25回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08431
[Presentation] 地域未治療高血圧患者における血管内皮機能からみた心不全予防の可能性．地域未治療高血圧患者における血管内皮機能からみた心不全予防の可能性．2021
- Author(s)
  西之園栞、安田聖子、廣岡良隆.
- Organizer
  第25回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08431
[Presentation] 循環細胞外小胞のアレイ解析の疾患バイオマーカーへの応用．2020
- Author(s)
  梅村創、高田勇吉、渋田樹、廣岡良隆
- Organizer
  第10回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-20K08431
[Presentation] 高血圧患者における新規リスク層別化開発：内皮機能・マイクロRNA探索．2020
- Author(s)
  廣岡良隆、安田聖子、梅村創
- Organizer
  第10回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-20K08431
[Presentation] 地域未治療高血圧患者における内皮機能異常と心不全指標との関係に関する観察研究．2020
- Author(s)
  西之園栞，廣岡良隆
- Organizer
  第24回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08431
[Presentation] Brain perivascular macrophages contribute to the development of hypertension via sympathetic activation.2019
- Author(s)
  Iyonaga T, Shinohara K, Matsuura T, Hirooka Y, Tsutsui H
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] 脳血管周囲マクロファージは交感神経活性化を介して高血圧の進展に寄与する．2019
- Author(s)
  篠原啓介、彌永武史、廣岡良隆、筒井裕之
- Organizer
  第42回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] 脳血管周囲マクロファージは交感神経活性化を介して高血圧の進展に寄与する．2019
- Author(s)
  篠原啓介、彌永武史、松浦託、廣岡良隆、筒井裕之
- Organizer
  第55回高血圧関連疾患モデル学会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] 高血圧における交感神経活性化：中枢性機序研究の進歩．2019
- Author(s)
  廣岡良隆
- Organizer
  第72回日本自律神経学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Central mechanisms of hypertension: brain-heart-kidney connectio.n2019
- Author(s)
  Hirooka Y.
- Organizer
  The 9th Federation of the Asian and Oceanian Physiological Societies Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Prior exposure to preeclampsia causes increased salt-sensitivity of blood pressure in postpatum period via increased vasopressin secretion.2019
- Author(s)
  Matsuura T, Shinohara K, Iyonaga T, Hirooka Y, Tsutsui H
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] 心不全の進展における高血圧の関与：心脳連関を含めた発症機序．2018
- Author(s)
  篠原啓介，柴田理紗，廣岡良隆，筒井裕之.
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Inflammation and immunity in hypertension and heart failure: role of brain AT1 receptors.2018
- Author(s)
  Hirooka Y.
- Organizer
  The 33rd Joint Annual Conference of Biomedical Science
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Preeclampsia induces acquired salt-sensitivity and increased vasopressin secretion in postpartum.2018
- Author(s)
  Matsuura T, Shinohara K, Hirooka Y, Tsutsui H.
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] 高血圧の発症・進展と免疫系・慢性炎症の役割．2018
- Author(s)
  廣岡良隆.
- Organizer
  第41回日本高血圧学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] 妊娠高血圧腎症の既往はバゾプレシン分泌を介して産後の食塩感受性を亢進させる．2018
- Author(s)
  松浦託，篠原啓介，彌永武史，柴田理紗，廣岡良隆，筒井裕之.
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Brain perivascular macrophages contribute to the development of hypertension via sympathetic activation.2018
- Author(s)
  Iyonaga T, Shinohara K, Hirooka Y, Tsutsui H.
- Organizer
  European Society of Cardiology Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] 急性期心不全治療の実臨床．2018
- Author(s)
  井上敬測，廣岡良隆
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] 脳血管周囲マクロファージは交感神経活性化を介して高血圧の進展に寄与する．2018
- Author(s)
  彌永武史，篠原啓介，松浦託，柴田理紗，廣岡良隆，筒井裕之.
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Preeclampsia induces the acquired salt-sensitivity characteristics via the increased vasopressin secretion in postpartum.2018
- Author(s)
  Matsuura T, Shinohara K, Hirooka Y, Tsutsui H.
- Organizer
  European Society of Cardiology Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] 妊娠高血圧腎症の既往はバゾプレシン分泌亢進により産後の食塩感受性を亢進させる．2018
- Author(s)
  松浦託，篠原啓介，彌永武史，廣岡良隆，筒井裕之.
- Organizer
  第54回高血圧関連疾患モデル学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats.2018
- Author(s)
  Iyonaga T, Shinohara K, Hirooka Y, Tsutsui H.
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Brain perivascular macrophages contribute to developing hypertension via sensing chronic peripheral inflammation.2017
- Author(s)
  Iyonaga T, Shinohara K, Kishi T, Tsutsui H, Hirooka Y.
- Organizer
  Experimental Biology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] 慢性腎臓病合併高血圧モデルマウスに対するオルメサルタンと腎除神経術併用は交感神経活動及び血中アルドステロンを抑制し強力な降圧効果を有する．2017
- Author(s)
  西原正章，武居講，廣岡良隆.
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] 心脳連関から見た高血圧・心不全の病態解明と治療への応用.2017
- Author(s)
  篠原啓介，柴田理紗，伊藤浩司，廣岡良隆，筒井裕之.
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Immunity and sympathetic nervous system in hypertension and heart failure: role of brain AT1 receptors.2017
- Author(s)
  Hirooka Y.
- Organizer
  The International Society for Autonomic Neuroscience 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] ニューロモデュレーション．2017
- Author(s)
  廣岡良隆
- Organizer
  第40回日本高血圧学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Astrocytes play a crucial role in enhanced sympathetic outflow in heart failure.2017
- Author(s)
  Hirooka Y.
- Organizer
  The International Society for Autonomic Neuroscience 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Disruptive arterial pressure stability is improved by sodium-glucose co-transporter 2 inhibitor in streptozocin-induced diabetic rats.2017
- Author(s)
  Yoshikawa T, Shinohara K, Kishi T, Tsutsui H, Hirooka Y.
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Reduced uterine perfusion pressure-induced preeclampsia acquires the salt-sensitivity characteristics of postpartum hypertension.2017
- Author(s)
  Matasuura T, Shinohara K, Kishi T, Tsutsui H, Hirooka Y.
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 脳血管周囲マクロファージは全身慢性炎症を感知し高血圧の発症に関与する．2017
- Author(s)
  彌永武史，篠原啓介，筒井裕之，廣岡良隆
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Reduced uterine perfusion pressure-induced preeclampsia acquires salt-sensitivity characteristics in postpartum.2017
- Author(s)
  Matsuura T, Shinohara K, Kishi T, Tsutsui H, Hirooka Y.
- Organizer
  Experimental Biology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] 妊娠高血圧腎発症は産後の食塩感受性を後天的に獲得させる．2017
- Author(s)
  松浦託，篠原啓介，筒井裕之，廣岡良隆.
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Increased BDNF in NTS by activation of cardiac afferent nerves is involved in sympatoexcitation in pressure overload-induced cardiac hypertrophy.2017
- Author(s)
  Shibata R, Shinohara K, Hirooka Y, Tsutsui H.
- Organizer
  第21回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Pharmacological transformation of hypothalamic microglia attenuates the development of hypertension in genetically hypertensive rats.2017
- Author(s)
  Takesue K, Shinohara K, Kishi T, Tsutsui H, Hirooka Y.
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Brain macrophages switch pre-hypertensive rats to the development hypertensive state via delivery of peripheral inflammatory information.2017
- Author(s)
  Iyonaga T, Shinohara K, Kishi T, Tsutsui H, Hirooka Y.
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 心臓求心性交感神経活性化を介した延髄孤束核のBDNF増加が心肥大における交感神経活動亢進に関与する．2017
- Author(s)
  柴田理紗，篠原啓介，伊藤浩司，岸拓弥，筒井裕之，廣岡良隆.
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K09508
[Presentation] Pressure overlaod-induced cardiac hypertrophy increases TRPV1 in heart and BDNF in NTS, suggesting baroreflex disruption via the brain-to-heart axis.2016
- Author(s)
  Shibata R, Shinohara K, Ito K, Kishi T, Tsutsui H, Hirooka Y.
- Organizer
  第20回日本心不全学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 高血圧における交感神経活性化と免疫系との関連．2016
- Author(s)
  廣岡　良隆
- Organizer
  第37回日本循環制御医学会総会
- Place of Presentation
  富山
- Year and Date
  2016-07-08
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Renal denervation exerts antihypertensive effect via enhancing GABA-ergic input paraventricular nucleus of hypothalamus with chronic kidney disease.2016
- Author(s)
  Takesue K, Nishihara M, Tsutsui H, Hirooka Y.
- Organizer
  第20回日本心不全学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 脳卒中易発症自然発症高血圧ラットにおいて視床下部室傍核の活性化ミクログリアは高血圧発症早期の血圧上昇を促進する．2016
- Author(s)
  武居　講，篠原　啓介，岸　拓弥，廣岡　良隆
- Organizer
  第39回日本高血圧学会総会
- Place of Presentation
  仙台
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Increased Expression of Thrombin Receptor, PAR1 is a New Therapeutic Target for Pulmonary Hypertension.2016
- Author(s)
  Kuwabara Y, Abe K, Hirano M, Hirooka Y, Sunagawa K, Hirano K.
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-23220013
[Presentation] SGLT2阻害薬はストレプトゾシン誘発性糖尿病ラットの血圧制御機能を改善する．2016
- Author(s)
  吉川　智子，篠原　啓介，岸　拓弥，廣岡　良隆，筒井　裕之
- Organizer
  第39回日本高血圧学会総会
- Place of Presentation
  仙台
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] NF-κB-Mediated Inflammation Plays a Key Role in Deteriorating RV Function in Pulmonary Artery Banding Rats.2016
- Author(s)
  Yoshida K, Abe K, Tanaka M, Shinoda M, Kuwabara Y, Saku K, Hirooka Y, Oka M, Sunagawa K.
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-23220013
[Presentation] 高血圧・心不全における交感神経活性化及び機序解明の進歩．2016
- Author(s)
  廣岡　良隆
- Organizer
  第69回日本自律神経学会総会
- Place of Presentation
  熊本
- Year and Date
  2016-11-10
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Critical Protective Role of Endogenous Nitric Oxide in Severe Pulmonary Arterial Hypertension in Rats.2016
- Author(s)
  Tanaka M, Abe K, Oka M, Schwenki D, Shirai M, Kuwahira I, Hirooka Y, Hoka S, Sunagawa K.
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-23220013
[Presentation] Immunity and sympathetic nervous system in hypertension.2016
- Author(s)
  Hirooka Y.
- Organizer
  The 17th International SHR Symposium
- Place of Presentation
  Tokyo
- Year and Date
  2016-09-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 基礎研究からみた病態を考慮した腎デナベーションの有効性．2016
- Author(s)
  廣岡　良隆
- Organizer
  第5回臨床高血圧フォーラム
- Place of Presentation
  大阪
- Year and Date
  2016-05-14
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Astrocytes are beyond supporting players on enhanced sympathetic outflow in heart failure.2016
- Author(s)
  Hirooka Y.
- Organizer
  FASEB Scientific Research Conference.
- Place of Presentation
  Saxton River, VT, USA
- Year and Date
  2016-07-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 高血圧発症・進展における自律神経制御異常．2015
- Author(s)
  廣岡良隆
- Organizer
  CVMW2015
- Place of Presentation
  神戸国際会議場（神戸市中央区）
- Year and Date
  2015-12-10
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Decreased proportion of regulatory T cells contributes to the development of hypertension and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats.2015
- Author(s)
  Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  グランフロント大阪　イベントラボ（大阪市北区）
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 脳内アンジオテンシンII受容体—酸化ストレス系が交感神経活性化の原因である．2015
- Author(s)
  岸拓弥，廣岡良隆，砂川賢二
- Organizer
  第36回日本循環制御医学会総会
- Place of Presentation
  ウインクあいち5F小ホール（名古屋市中村区）
- Year and Date
  2015-06-05
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 高血圧のデバイス治療．2015
- Author(s)
  廣岡良隆
- Organizer
  第38回日本高血圧学会総会
- Place of Presentation
  愛媛県県民文化会館（松山市道後町）
- Year and Date
  2015-10-09
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Activation of hypothalamic mineralocorticoid receptor-independent epithelial sodium channels leads to salt sensitive hypertension in mouse model of metabolic syndrome.2015
- Author(s)
  Kunita-Takanezawa M, Ito K, Kishi T, Hirooka Y.
- Organizer
  Scientific Sessions 2015
- Place of Presentation
  Orlando（USA）
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Immunity and sympathetic nervous system in hypertension.2015
- Author(s)
  Hirooka Y.
- Organizer
  The 8th Federation of Asian and Oceanian Physiological Societies Congress
- Place of Presentation
  Bangkok（Thailand）
- Year and Date
  2015-11-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Brain angiotensin type 1 receptor activation plays a crucial role in immune-inflammatory mechanisms of central sympathoexcitation in hypertension and heart failure.2015
- Author(s)
  Hirooka Y.
- Organizer
  9th Meeting of the International Society for Autonomic Neuroscience (ISAN 2015), EFAS, AAS, JSNR
- Place of Presentation
  Stresa（Italy）
- Year and Date
  2015-09-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Hypothalamic activated microglia with morphological changes accelerate blood pressure elevation during the hypertension development phase in stroke-prone hypertensive rats.2015
- Author(s)
  Takesue K, Kishi T, Hirooka Y.
- Organizer
  Scientific Sessions 2015
- Place of Presentation
  Orlando（USA）
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] メタボリック症候群モデルマウスにおける食塩感受性高血圧の脳内機序においてミネラルコルチコイド受容体非依存性の脳内上皮性Naチャネル活性化が重要である．2015
- Author(s)
  髙根澤睦，伊藤浩司，岸拓弥，廣岡良隆
- Organizer
  第38回日本高血圧学会総会
- Place of Presentation
  愛媛県県民文化会館（松山市道後町）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Current status and expectation of baroreflex activation therapy and vagal nerve stimulation in heart failure.2015
- Author(s)
  Hirooka Y.
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  リーガロイヤルホテル大阪（大阪市北区）
- Year and Date
  2015-04-24
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 脳視床下部室傍核ミクログリア形態変化の自然発症高血圧ラット発症早期メカニズムにおける重要性．2015
- Author(s)
  武居講，岸拓弥，廣岡良隆
- Organizer
  第38回日本高血圧学会総会
- Place of Presentation
  愛媛県県民文化会館（松山市道後町）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Pressure overload-induced cardiac hypertrophy increases brain-derived neurotrophic factor in nucleus tractus solitarius suggesting disruption of the baroreflex via heart-to-brain axis.2015
- Author(s)
  Takenaka R, Ito K, Kishi T, Hirooka Y.
- Organizer
  第19回日本心不全学会学術集会
- Place of Presentation
  グランフロント大阪　ナレッジキャピタルコングレコンベンションセンター（大阪市北区）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Angiotensin II type 1 receptor expression in astrocytes is upregulated leading to increased mortality in mice with heart failure.2015
- Author(s)
  Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  グランフロント大阪　ナレッジキャピタルコングレコンベンションセンター（大阪市北区）
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Decreased Foxp3+CD4+regulatory T cells contribute to the development of hypertension in genetically hypertensive rats.2014
- Author(s)
  Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-10-17
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Astrocyte-specific angiotensin II type 1 receptor knockout by using Cre-loxp system attenuates left ventricular remodeling after myocardial infarction.2014
- Author(s)
  Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  Experimental Biology 2014
- Place of Presentation
  San Diego
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 食事性肥満モデルマウスを用いたメタボリック症候群における食塩感受性高血圧の脳内機序の検討．2014
- Author(s)
  髙根澤睦，伊藤浩司，廣岡良隆，砂川賢二
- Organizer
  第50回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  和歌山県立医科大学生涯研修センター
- Year and Date
  2014-12-05
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 脳からみた高血圧症．2014
- Author(s)
  廣岡良隆
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-10-19
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 心臓交感神経シンチグラフィーを用いた肺高血圧症の非侵襲的な重症度評価法の確立．2014
- Author(s)
  阿部弘太郎、長尾充展、廣岡良隆、砂川賢二
- Organizer
  第62回日本心臓病学会学術集会
- Place of Presentation
  仙台市民会館
- Year and Date
  2014-09-28
- Invited
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] RV sympathetic dysfunction parallels RV performance in patients with pulmonary arterial hypertension.2014
- Author(s)
  Abe K, Nagao M, Hirooka Y, Sunagawa K.
- Organizer
  第78回日本循環器学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] Inhibition of Increased Thrombin Receptor Activity Attenuated Monocrotaline-induced Pulmonary Hypertension in Rats.2014
- Author(s)
  Kuwabara Y, Abe K, Hirano M, Hirooka Y, Hirano K, Sunagawa K.
- Organizer
  American Heart Association Scientific Sessions 2014
- Place of Presentation
  Chicago
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] 交感神経系．2014
- Author(s)
  廣岡良隆
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 脳卒中易発症高血圧自然発症ラットの高血圧発症・進展過程に制御性T細胞の減少および脾臓交感神経入力が関与する．2014
- Author(s)
  甲木雅人，廣岡良隆，砂川賢二
- Organizer
  第50回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  和歌山県立医科大学生涯研修センター
- Year and Date
  2014-12-05
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 心不全と交感神経・圧受容器反射感受性．2014
- Author(s)
  廣岡良隆
- Organizer
  第18回日本心血管内分泌代謝学会学術集会
- Place of Presentation
  横浜市開港記念会館
- Year and Date
  2014-11-21
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Renal nerve denervation exerts antihypertensive effects via enhancing GABA-ergic input to paraventricular nucleus in hypertensive mice with chronic kidney disease.2014
- Author(s)
  Nishihara M, Hirooka Y, Sunagawa K.
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Left unilateral pulmonary artery banding prevents the development of plexogenic arteriopathy in rats with severe pulmonary arterial hypertension.2014
- Author(s)
  Abe K, Oka M, Shinoda M, Kuwabara Y, McMurtry IF, Hirooka Y, Sunagawa K.
- Organizer
  第78回日本循環器学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] Central nervous system mechanisms involved in RDN and BAT.2014
- Author(s)
  Hirooka Y.
- Organizer
  American Heart association Scientific Sessions 2014
- Place of Presentation
  Chicago
- Year and Date
  2014-11-17
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Occlusive Vascular Remodeling Is A Consequence Of Hemodynamic Stress In Rats With Severe Pulmonary Arterial Hypertension.2014
- Author(s)
  Abe K, Shinoda M, Kuwabara Y, McMurtry IF, Hirooka Y, Sunagawa K, Oka M.
- Organizer
  American Thoracic Society International Conference 2014
- Place of Presentation
  San Diego
- Year and Date
  2014-05-21
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] 肺高血圧症におけるトロンビン受容体PAR1の肺動脈収縮作用の亢進．2014
- Author(s)
  桑原志実、阿部弘太郎、平野真弓、廣岡良隆、平野勝也、砂川賢二
- Organizer
  第2回日本肺高血圧学会・第3回日本肺循環学会合同学術集会
- Place of Presentation
  大手町サンケイプラザ
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] Preventive effects of thrombin receptor antagonist on hemodynamic parameters and histological findings in monocrotaline-induced pulmonary hypertension rats.2014
- Author(s)
  Kuwabara Y, Abe K, Hirano M, Hirooka Y, Hirano K, Sunagawa K.
- Organizer
  第78回日本循環器学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] Decreased T-regulatory cells are associated with blood pressure elevation and sympathoexcitation in hypertensive rats.2014
- Author(s)
  Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  Experimental Biology 2014
- Place of Presentation
  San Diego
- Year and Date
  2014-04-28
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Targeted deletion of astrocyte-specific angiotensin II type 1 receptor strikingly improves prognosis of myocardial infarction-induced heart failure.2014
- Author(s)
  Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  第18回日本心不全学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-10-12
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 中枢性循環制御機構の解明と展望．2014
- Author(s)
  廣岡良隆
- Organizer
  第35回日本循環制御医学会総会
- Place of Presentation
  九州大学医学部百年講堂
- Year and Date
  2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Decreases in T-regulatory lymphocytes precede blood pressure elevation in stroke-prone spontaneously hypertensive rats.2014
- Author(s)
  Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 肺高血圧症における右室交感神経活動障害は、右心機能障害に比例する．2014
- Author(s)
  阿部弘太郎、廣岡良隆、砂川賢二
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  リーガロイヤルホテル大阪
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] アストロサイト特異的AT1受容体阻害は心筋梗塞後の左室リモデリングを抑制する．2014
- Author(s)
  伊勢川健吾，廣岡良隆，岸拓弥，砂川賢二
- Organizer
  第35回日本循環制御医学会総会
- Place of Presentation
  九州大学医学部百年講堂
- Year and Date
  2014-07-04
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Genetic ablation of astrocyte-specific angiotensin II type 1 receptors improves prognosis of myocardial infarction-induced heart failure.2014
- Author(s)
  Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  American Heart association Scientific Sessions 2014
- Place of Presentation
  Chicago
- Year and Date
  2014-11-16
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] In vivo induction of regulatory T cells delays the development of hypertension in stroke-prone spontaneously hypertensive rats.2014
- Author(s)
  Katsuki M, Hirooka Y, Sunagwa K.
- Organizer
  American Heart association Scientific Sessions 2014
- Place of Presentation
  Chicago
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Targeted deletion of angiotensin II type 1 receptor in astrocytes inhibits left ventricular remodeling after myocardial infarction in mice.2014
- Author(s)
  Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 脳卒中易発症性自然発症高血圧ラットの高血圧形成過程において制御性T細胞の減少と脾臓交感神経が関与する．2014
- Author(s)
  甲木雅人，廣岡良隆，岸拓弥，砂川賢二
- Organizer
  第35回日本循環制御医学会総会
- Place of Presentation
  九州大学医学部百年講堂
- Year and Date
  2014-07-04
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] メタボリック症候群モデルマウスにおける食塩感受性高血圧は脳内上皮型Naチャネル活性化を介している．2014
- Author(s)
  髙根澤睦，伊藤浩司，廣岡良隆，砂川賢二
- Organizer
  第35回日本循環制御医学会総会
- Place of Presentation
  九州大学医学部百年講堂
- Year and Date
  2014-07-05
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Brain angiotensin II type 1 receptor blockade ameliorates the development of atrial fibrillation via sympathoinhibition independent of depressor response in hypertensive rats.2014
- Author(s)
  Nagayama T, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  American Heart association Scientific Sessions 2014
- Place of Presentation
  Chicago
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Involvement of decreases in regulatory T cells and splenic sympathetic nerve in the development of hypertension in genetically hypertensive rats.2014
- Author(s)
  Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  High Blood Pressure Research Scientific Sessions 2014
- Place of Presentation
  San Francisco
- Year and Date
  2014-09-10
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] トロンビン受容体拮抗薬はモノクロタリンによる肺高血圧の誘発を抑制する．2014
- Author(s)
  桑原志実、阿部弘太郎、平野真弓、廣岡良隆、平野勝也、砂川賢二
- Organizer
  第35回日本循環制御医学会総会
- Place of Presentation
  九州大学医学部百年講堂
- Year and Date
  2014-07-04
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] 中枢性AT1受容体の阻害は高血圧ラットの心房細動持続時間を降圧度非依存性に抑制する．2014
- Author(s)
  長山友美，岸拓弥，廣岡良隆，樗木晶子，向井靖，井上修二朗，砂川賢二
- Organizer
  第35回日本循環制御医学会総会
- Place of Presentation
  九州大学医学部百年講堂
- Year and Date
  2014-07-04
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Central sympathoinhibition by moxonidine suppresses brain oxidative stress, prevents cardiac remodeling and improves prognosis in rats with hypertensive heart failure2013
- Author(s)
  Honda N, Hirooka Y, et al.
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2013-03-17
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Aldosterone-independent MR activation in the choroid plexus increases Na^+ in cerebrospinal fluid and induces synpathoexcitation instroke-prone spontaneously hypertensive rats2013
- Author(s)
  Nakano M, Hirooka Y, et al.
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2013-03-15
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] A New Endothelin Receptor Antagonist Macitentan Prevents Endothelin-1 Induced Contraction in Intrapulmonary Arteries in Rats with Severe Pulmonary Arterial Hypertension.2013
- Author(s)
  Kunita M, Abbe K, Hirooka Y, Hirano K, Sunagawa K.
- Organizer
  35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
- Place of Presentation
  Osaka, Japan
- Data Source
  KAKENHI-PROJECT-23220013
[Presentation] Combining irbesartan and trichlormethiazide elicits strong blood pressure reduction associated with sympathoinhibition and beneficial metabolic profiles in hypertensive rats with metabolic syndrome.2013
- Author(s)
  Nishihara M, Hirooka Y, Sunagawa K.
- Organizer
  High Blood Pressure Research Scientific Sessions 2013
- Place of Presentation
  New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 腎除神経は高血圧性心不全ラットにおいて利尿作用により心機能障害を抑制し、生命予後を改善する．2013
- Author(s)
  本田修浩、廣岡良隆、伊藤浩司、砂川賢二
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Splenic T regulatory lymphocytes are reduced in genetically hypertensive rats associated with sympathoinhibition.2013
- Author(s)
  Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  High Blood Pressure Research Scientific Sessions 2013
- Place of Presentation
  New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Central sympathoinhibition induced by blockade of brain AT1 receptors ameliorates the reduction of splenic regulatory T cells in hypertensive rats2013
- Author(s)
  Katsuki M, Hirooka Y, et al.
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2013-03-15
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 新しいエンドセリン受容体拮抗薬、マシテンタンの慢性投与は肺高血圧モデルラットの病態進行を抑制する．2013
- Author(s)
  國田睦，阿部弘太郎，廣岡良隆，砂川賢二．
- Organizer
  第61回日本心臓病学会学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] Vasoconstriction is an important therapeutic target in severe pulmonaryarterial hypertension.2013
- Author(s)
  阿部弘太郎、廣岡良隆、他
- Organizer
  第77回日本循環器学会学術集会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] Different role of oxidative stress in paraventricular nucleus and rostral ventrolateral medulla in cardiovascular regulation in awake spontaneously hypertensive rats. (YIA受賞)2013
- Author(s)
  Nishihara M, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] A new endothelin receptor antagonist macitentan is a potent vasodilatorin intrapulmonary arteries in rats with severe pulmonary hypertension.2013
- Author(s)
  國田睦、阿部弘太郎、廣岡良隆、他
- Organizer
  第77回日本循環器学会学術集会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] High Voltage, Not Age and Blood Pressure, of Stimulus Exaggerates Inducibility of Atrial Fibrillation by Rapid Electrical Stimulation in Hypertensive Rats.2013
- Author(s)
  Nagayama T, Kishi T, Hirooka Y, Sunagawa K.
- Organizer
  35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
- Place of Presentation
  Osaka, Japan
- Data Source
  KAKENHI-PROJECT-23220013
[Presentation] イルベサルタンとトリクロルメチアジドの併用療法は高血圧を合併するメタボリックシンドロームモデル動物の脂質糖代謝へ影響を与えず交感神経活動を抑制し強力な降圧効果を有する．2013
- Author(s)
  西原正章、廣岡良隆、砂川賢二
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Device therapy in hypertension.（Organizer and Symposium speaker）2013
- Author(s)
  Hirooka Y
- Organizer
  35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Chronic administration of proteinase-activated receptor 1 (PAR-1) antagonist attenuated monocrotaline-induced pulmonary hypertension in rats.2013
- Author(s)
  桑原　志実、阿部弘太郎、平野　勝也、廣岡良隆、他
- Organizer
  第77回日本循環器学会学術集会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] Central Sympathoinhibition Ameliorates the Reduction of Splenic Regulatory T Cells with Decreased IL-17 Production in Hypertensive Rats2013
- Author(s)
  Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  Experimental Biology 2013
- Place of Presentation
  Boston, U.S.A.
- Data Source
  KAKENHI-PROJECT-23220013
[Presentation] AT1 receptors and Oxidative Stress in the RVLM Are the Possible Therapeutic Target for Hypertension2013
- Author(s)
  Hirooka Y
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 高血圧から心不全に至る交感神経系の役割．（シンポジスト）2013
- Author(s)
  廣岡良隆
- Organizer
  第49回高血圧関連疾患モデル学会学術集会総会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Ideal Depressor Effect of New Angiotensin II Receptor Blocker, Azilsartan, Around Rest-To-Active Phase in Hypertensive Rats.2013
- Author(s)
  Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
- Place of Presentation
  Osaka, Japan
- Data Source
  KAKENHI-PROJECT-23220013
[Presentation] Central sympathoinhibition by moxonidine attenuates brain oxidative stress, prevented cardiac dysfunction and improved prognosis in rats with hypertensive heart failure.2013
- Author(s)
  Honda N, Hirooka Y, Ito K, Matsukawa R, Sunagawa K.
- Organizer
  Scientific Sessions 2013
- Place of Presentation
  Dallas, TX, USA
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Circulating angiotensin II leads to left ventricular diastolic dysfunction through sympathoexcitation with intrinsic brain AT1 receptor activation2013
- Author(s)
  Shinohara K, Hirooka Y, et al.
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2013-03-16
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Central Sympathoinhibition by Moxonidine Attenuated Brain Oxidative Stress, Prevented Cardiac Dysfunction and Improved Prognosis in Rats With Hypertensive Heart Failure.2013
- Author(s)
  Honda N, Hirooka Y, Ito K, Matsukawa R, Sunagawa K.
- Organizer
  American Heart Association Scientific Sessions 2013
- Place of Presentation
  Dallas, U.S.A
- Data Source
  KAKENHI-PROJECT-23220013
[Presentation] アジルサルタンは高血圧モデルラットにおいて強力な平均血圧低下作用に加え睡眠→覚醒時の血圧上昇を抑制する．2013
- Author(s)
  伊勢川健吾、廣岡良隆、岸拓弥、砂川賢二
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Splenic Regulatory T Cells Were Associated with AT1 Receptors in the Brain in Hypertensive Rats.2013
- Author(s)
  Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
- Place of Presentation
  Osaka, Japan
- Data Source
  KAKENHI-PROJECT-23220013
[Presentation] Central Sympathoinhibition by Moxonidine Improves Prognosis in Rats with Hypertensive Heart Failure.2013
- Author(s)
  Honda N, Hirooka Y, Sunagawa K.
- Organizer
  35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
- Place of Presentation
  Osaka, Japan
- Data Source
  KAKENHI-PROJECT-23220013
[Presentation] Azilsartan, New Angiotensin II Type 1 Receptor Blocker, Would Suppress Morning Surge in Hypertension.2013
- Author(s)
  Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  Experimental Biology 2013
- Place of Presentation
  Boston, U.S.A.
- Data Source
  KAKENHI-PROJECT-23220013
[Presentation] Crucial Role of Proteinase-Activated Receptor 1 in the Development of Monocrotaline Induced Pulmonary Arterial Hypertension in Rats.2013
- Author(s)
  Kuwabara Y, Abe K, Hirano M, Hirooka Y, Sunagawa K, Hirano K.
- Organizer
  American Heart Association Scientific Sessions 2013
- Place of Presentation
  Dallas, U.S.A
- Data Source
  KAKENHI-PROJECT-23220013
[Presentation] A Novel Endothelin Receptor Antagonist, Macitentan Markedly Improved Severe Pulmonary Arterial Hypertension in Rats by a Nearly Complete Blockade of Endothelin Receptors.2013
- Author(s)
  Kunita M, Abe K, Hirooka Y, Kuwabara Y, Hirano K, Oka M, Sunagawa K.
- Organizer
  American Heart Association Scientific Sessions 2013
- Place of Presentation
  Dallas, U.S.A
- Data Source
  KAKENHI-PROJECT-23220013
[Presentation] Central sympathoinhibition by moxonidine attenuates brain oxidative stress, prevents cardiac remodeling and improves prognosis associated with reduction of sympathetic hyperactivity in rats with hypertensive heart failure.2013
- Author(s)
  Honda N, Hirooka Y, Matsukawa R, Ito K, Sunagawa K.
- Organizer
  Experimental Biology 2013
- Place of Presentation
  Boston, U.S.A.
- Data Source
  KAKENHI-PROJECT-23220013
[Presentation] Brain angiotensin II type 1 receptors in astrocytes, not neurons, are upregulated in mice with myocardial infarction-induced heart failure.2013
- Author(s)
  Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
- Organizer
  第17回日本心不全学会学術集会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] A Novel endothelin receptor antagonist, macitentan markedly improved severe pulmonary arterial hypertension in rats by a near complete blockade of endothelin receptors.2013
- Author(s)
  Kunita M, Abe K, Hirooka Y, Kuwabara Y, Hirano K, Sunagawa K.
- Organizer
  Scientific Meeting of the American Heart Association 2013
- Place of Presentation
  ダラス（米国）
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] 希少疾患である肺高血圧症の教育活動により心エコー技師への肺高血圧症に対する評価意識が高まる2013
- Author(s)
  河原　吾朗、阿部弘太郎、廣岡良隆、他
- Organizer
  第77回日本循環器学会学術集会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] Long-term treatment with novel endothelin receptor antagonist macitentan markedly attenuated severe pulmonary hypertension with angioproliferative occlusive lesions in rats.2013
- Author(s)
  Abe K, Kunita M, Hirooka Y, Kuwabara Y, Hirano K, Sunagawa K.
- Organizer
  2013 American Thoracic Society International Conference
- Place of Presentation
  フィラデルフィア（米国）
- Invited
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] Brain AT1 receptors as a therapeutic target for hypertension via oxidative stress and inflammatory response2012
- Author(s)
  Hirooka Y
- Organizer
  The 29th Annual Meeting of the International Society for Heart Research Japanese Section
- Place of Presentation
  福岡
- Year and Date
  2012-10-27
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Brain senses the circulating angiotensin II substantially leading to leftventricular diastolic dysfunction through the central Sympathoexcitation2012
- Author(s)
  Shinohara K, Hirooka Y, et al.
- Organizer
  Scientific Sessions 2012
- Place of Presentation
  Los Angels, CA, USA
- Year and Date
  2012-11-05
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 高血圧・心不全の病態における循環中枢異常による交感神経活性化2012
- Author(s)
  廣岡良隆
- Organizer
  第60回日本心臓病学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2012-09-14
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] The brain AT1R are responsible for sympathoexcitation associated with brain MR activation in mice with pressure overload after salt loading2012
- Author(s)
  Ito K, Hirooka Y, et al.
- Organizer
  Scientific Sessions 2012
- Place of Presentation
  Los Angels, CA, USA
- Year and Date
  2012-01-05
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 高血圧におけるRVLM機能異常と酸化ストレス2012
- Author(s)
  廣岡良隆
- Organizer
  第35回日本高血圧学会・SHR学会合同シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Targeting the ATI receptors in the RVLM for therapeutic aspects2012
- Author(s)
  Hirooka Y
- Organizer
  Satellite Meeting of the International Society of Hypertension
- Place of Presentation
  Palm Cove, Queens land, Australia
- Year and Date
  2012-09-27
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Central NRG-1/ErbB signaling has a pivotal role in the regulation of sympathetic nerve activity in pressure overload-induced heart failure2012
- Author(s)
  Matsukawa R, Hirooka Y, et al.
- Organizer
  第35回日本高血圧学会総会
- Place of Presentation
  名古屋
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Cardiac sympathetic afferents stimulation increases brain ENaCs, thereby concomitant salt loading leads to sympathoexcitation2012
- Author(s)
  Ito K, Hirooka Y, et al.
- Organizer
  Scientific Sessions 2012
- Place of Presentation
  Los Angels, CA, USA
- Year and Date
  2012-11-05
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Cardiac Sympathetic Activity evaluated by 123I-MIBG Myocardial Scintigraphy in Patients with Right Ventricular Dysfunction Associated with Pulmonary Arterial Hypertension.2012
- Author(s)
  阿部弘太郎、廣岡良隆、他
- Organizer
  2013年米国胸部疾患学会総会
- Place of Presentation
  サンフランシスコ（アメリカ）
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] Reduced splenic and circulating T regulatory cells contribute to sympathoexcitation through central AT1 receptors in hypertensive rats2012
- Author(s)
  Katsuki M, Hirooka Y, et al.
- Organizer
  Scientific Sessions 2012
- Place of Presentation
  Los Angels, CA, USA
- Year and Date
  2012-11-05
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Iodine-123-Metaiodobenzylguanidine (MIBG)心筋シンチグラフィを用いた肺動脈性肺高血圧症患者の右室の交感神経活動の評価2012
- Author(s)
  阿部弘太郎、廣岡良隆、他
- Organizer
  第33回日本循環制御医学会総会
- Place of Presentation
  栃木
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] Mineralocorticoid receptors (MR)/epithelial Na Channels (ENaCs)pathway activation in choroid plexus exaggerates salt-induced hypertension with sympathoexcitation in stroke-prone spontaneously hypertensive rats2012
- Author(s)
  Nakano M, Hirooka Y, et al.
- Organizer
  Scientific Sessions 2012
- Place of Presentation
  Los Angels, CA, USA
- Year and Date
  2012-11-05
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] 心臓MRIによる三尖弁輪収縮期移動距離(TAPSE)は肺高血圧症患者の右心機能評価に有用である2012
- Author(s)
  阿部弘太郎、廣岡良隆、他
- Organizer
  第60回日本心臓病学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-24659393
[Presentation] Mechanisms involved in activation of the sympathetic nervous system in hypertension : oxidative stress in the brainstem and hypothalamus2012
- Author(s)
  Hirooka Y
- Organizer
  The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry/55th Annual Meeting of the Japanese Society for Neurochemistry
- Place of Presentation
  神戸
- Year and Date
  2012-09-29
- Data Source
  KAKENHI-PROJECT-24390198
[Presentation] Angiotensin (1-7) into rostral ventrolateral medulla is enhanced in spontaneously hypertensive rats2010
- Author(s)
  Nakagaki T, Hirooka Y, Ito K, Hoka S, Sunagawa K.
- Organizer
  Experimental Biology 2010.
- Place of Presentation
  Anaheim, U.S.A.
- Year and Date
  2010-04-26
- Data Source
  KAKENHI-PROJECT-18100006
[Presentation] Telmisartan inhibits sympathetic nerve activity through the inhibition of oxidative stress and increase in NO and GABA in the brain of hypertensive rats.2010
- Author(s)
  Kishi T, Hirooka Y, Sunagawa K.
- Organizer
  Experimental Biology 2010.
- Place of Presentation
  Anaheim, U.S.A.
- Year and Date
  2010-04-26
- Data Source
  KAKENHI-PROJECT-18100006
[Presentation] 高血圧の病態における脳内RASの役割:酸化ストレスを介した交感神経活性化【シンポジウム】2010
- Author(s)
  廣岡良隆
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-19390231
[Presentation] Telmisartan improves cognitive function through the increase in neurotrophic factor and inhibition of apoptosis in hippocampus of rats with metabolic syndrome.2010
- Author(s)
  Kishi T, Hirooka Y, Sunagawa K.
- Organizer
  Experimental Biology 2010
- Place of Presentation
  Anaheim, U.S.A.
- Year and Date
  2010-04-27
- Data Source
  KAKENHI-PROJECT-18100006
[Presentation] 血圧の神経性調節【教育セッション】2010
- Author(s)
  廣岡良隆
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-19390231
[Presentation] Telmisartan inhibits sympathetic nerve activity through the reduction of oxidative stress and release of GABA in RVLM of hypertensive rats.2010
- Author(s)
  Kishi T, Hirooka Y, Sunagawa K.
- Organizer
  Experimental Biology 2010
- Place of Presentation
  Anaheim, U.S.A.
- Year and Date
  2010-04-26
- Data Source
  KAKENHI-PROJECT-18100006
[Presentation] Brain salt sensitivity in mice with LVH is enhanced via Rho-kinase pathway through ENaC activation.2009
- Author(s)
  Ito K, Hirooka Y, Sunagawa K.
- Organizer
  Experimental Biology 2009.
- Place of Presentation
  New Orleans, U.S.A.
- Year and Date
  2009-04-19
- Data Source
  KAKENHI-PROJECT-18100006
[Presentation] The Reduction of Brain Sigma-1 Receptor Contributes to Sympathetic Hyperactivation in Heart Failure.2009
- Author(s)
  Ito K, Hirooka Y, Sunagawa K.
- Organizer
  Scientific Sessions 2009 of the American Heart Association.
- Place of Presentation
  Orland, U.S.A.
- Year and Date
  2009-11-18
- Data Source
  KAKENHI-PROJECT-18100006
[Presentation] Left Ventricular Hypertrophy Enhances the Expression of Mineralocorticoid Receptor and Epithelial Na Channels in the Brain and Leads to Salt-sensitive Sympathetic Hyperactivation and Left Ventricular Dysfunction.2009
- Author(s)
  Ito K, Hirooka Y, Sunagawa K.
- Organizer
  Scientific Sessions 2009 of the American Heart Association.
- Place of Presentation
  Orland, U.S.A.
- Year and Date
  2009-11-18
- Data Source
  KAKENHI-PROJECT-18100006
[Presentation] Role of nitric oxide and oxidative stress within the brain in neural influencesin hypertension2008
- Author(s)
  Hirooka Y
- Organizer
  第72回日本循環器学会総会・学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2008-03-30
- Data Source
  KAKENHI-PROJECT-19390231
[Presentation] Role of nitric oxide and oxidative stress within the brain in neural influences in hypertension. (Symposium).2008
- Author(s)
  廣岡良隆
- Organizer
  第72回日本循環器学会総会・学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2008-03-30
- Data Source
  KAKENHI-PROJECT-19390231
[Presentation] Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction.2007
- Author(s)
  Tsutsumi T, Ide T, Yamato M, Kudou W, Andou M, Hirooka Y, Utsumi H, Tsutsui H, Sunagawa K.
- Organizer
  Heart Association.
- Place of Presentation
  Orland, U.S.A.
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-18100006
[Presentation] High salt diet exacerbates hypertension via increased oxidative stress in the rostral ventrolateral medulla and sympathetic hyperactivity in spontaneously hypertensive rats.2007
- Author(s)
  Koga Y, Hirooka Y, Araki S, Nozoe M, Kishi T, Sunagawa K.
- Organizer
  Heart Association.
- Place of Presentation
  Orland, U.S.A.
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-18100006
[Presentation] Impaired neurogenesis in the rostral ventrolateral medulla causes hypertension in stroke-prone spontaneously hypertensive rats.2007
- Author(s)
  Kishi T, Hirooka Y, Sunagawa K.
- Organizer
  Heart Association.
- Place of Presentation
  Orland, U.S.A.
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-18100006
[Presentation] 血圧調節機構の根幹に迫る:中枢・交感神経の研究2007
- Author(s)
  廣岡良隆
- Organizer
  第30回日本高血圧学会総会
- Place of Presentation
  沖縄コンベンションセンター
- Year and Date
  2007-10-26
- Data Source
  KAKENHI-PROJECT-19390231

1. KISHI Takuya (70423514)

# of Collaborated Projects: 6 results

# of Collaborated Products: 73 results
2. UTSUMI Hideo (20101694)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. IDE Tomomi (90380625)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. SHIMOKAWA Hiroaki (00235681)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. SUNAGAWA Kenji (50163043)

# of Collaborated Projects: 2 results

# of Collaborated Products: 52 results
6. KAWADA Toru (30243752)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ESHIMA Kenichi (20444804)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 伊藤浩司 (10452757)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
9. 安田聖子 (70747097)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
10. TODAKA Koji (40398061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. CHISYAKI Akiko (60216497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ICHIKAWA Kazuhiro (10271115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAMADA Ken-ichi (60346806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HYODO Fuminori (10380693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YASUKAWA Keiji (80372738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. YAMATO Mayumi (30380695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KATO Takahiro (70546465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ABE Kohtaro (20588107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 24 results
19. ICHIKI Toshihiro (80311843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TAKESHIGE Kouichirou (10037450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. AKAIKE Takaaki (20231798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. IBAYASHI Setsurou (40213201)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NUTTAVUT Kosem (60532851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 西原正章 (70641017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
25. 梅村創 (90136432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
26. 篠原啓介 (30784491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
27. 金子秀雄 (20433617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 堀江淳 (60461597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 西之園栞 (70907948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 田川辰也

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. UEDA Mitsuharu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 安東由喜雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirooka Yoshitaka 廣岡 良隆

HIROOKA Yoshitaka 廣岡 良隆

Research Projects

Research Products

Co-Researchers

慢性心不全患者の横隔膜機能低下スクリーニングツールと効果的なトレーニング法の開発

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Project Period (FY)

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Development of novel risk stratification index in hypertensive patients: endothelial function and microRNAPrincipal Investigator

Principal Investigator

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Review Section

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Mechnistic elucidation and diagnostic development of autonomic nervous system and immunity network in hypertensionPrincipal Investigator

Principal Investigator

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Sympathetic activation in heart failure: Elucidation of a novel framework and the control mechanismsPrincipal Investigator

Principal Investigator

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Novel aspects for the role and therapy of autonomic nervous system in pulmonary hypertension toward right ventricular heart failurePrincipal Investigator

Principal Investigator

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Explorations into development of autonomic neuromodulation system to treat refractory heart failure

Principal Investigator

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Imaging study of redox status in vivo in oxidative stress-associateddisease model animals using OMRI

Principal Investigator

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中枢性睡眠時無呼吸合併慢性心不全患者に対するfMRIを使用した延髄機能異常の解明

Principal Investigator

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Hypertension in metabolic syndrome : Mechanism involved in activation of the sympathetic nervous system and therapeutic approachPrincipal Investigator

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Explorations into development of bionic baroreflex system to overcome arterial pressure dysregulation in patients with cervical cord injury

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Role of Racl-derived reactive oxygen species in the vasomotor center of the brain in hypertensionPrincipal Investigator

Principal Investigator

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Experimental and Clinical Studies on the Significance of Endothelium-Derived Hyperpolarizing Factor (EDHF)

Principal Investigator

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Role of reactive oxygen species within the vasomotor center of the brain in hypertensionPrincipal Investigator

Principal Investigator

Project Period (FY)

Hirooka Yoshitaka 廣岡良隆

HIROOKA Yoshitaka 廣岡良隆

[Book] 腎疾患治療薬　update2021

[Book] 中枢性血圧調節機構　「Annual Review 循環器 2016」（分担執筆）2016

[Book] 血圧変動　エビデンス＆プラクティス2016

[Book] 治療抵抗性高血圧に腎デナベーションは有効ではないのか？（SYMPLICITY IIIを受けて）．「EBM循環器疾患の治療　2015-2016」（分担執筆）2015