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GOTO Kiminobu  後藤 公宣

ORCIDConnect your ORCID iD *help
Researcher Number 90284512
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2003 – 2005: Kyushu University, assistant professor, 大学病院, 助手
2004: 九州大学, 大学究院, 助手
2002: 九州大学, 医学部附属病院, 助手
2001 – 2002: Graduate School of Medical Sciences, Medicine and Bioregulatory Science, Kyushu University, Assistant Professor, 大学院・医学研究院, 助手
2000: 九州大学, 医学部・附属病院, 助手
1999: 九州大学, 大学院・医学系研究科, 助手
Review Section/Research Field
Principal Investigator
Endocrinology
Except Principal Investigator
Endocrinology / Endocrinology / Biological Sciences
Keywords
Principal Investigator
activation function-1 / mammalian two-hybrid / subnuclear compartment / nuclear localization signal / confocal microscopy / transcriptional coactivator / androgen receptor / スプライシング因子 / コアクチベーター / AF-1 … More / GFP / 核内クラスター / mammalian two-hybrid法 / 分子内機能ドメイン / Activation Function-1 / 転写活性化能 / 共焦点顕微鏡 / 核移行シグナル / 核内コンパートメント / 転写共役因子 / アンドロゲン受容体 … More
Except Principal Investigator
TPR / cDNA cloning / AR AF-1 / Yeast two-hybrid assay / ANT-1 / アンドロゲン / Smad2 / GFP / ステロイドホルモン / 共役因子 / GSTプルダウン / アンドロゲン受容体 / cell therapy / tissue stem cell / bone marrow / steroid hormone / regeneration / adrenal gland / 組織幹細胞 / 骨髄細胞 / 再生 / 副腎 / Transgenic mouse / Insulin / Knock out mouse / Pancreatic beta cell / Activin / ES細胞 / アクチビン受容体 / Smad / ノックアウトマウス / Cre-loxP / インスリン / 遺伝子改変マウス / 膵β細胞 / アクチビン / N-CoR / post-receptor / androgen / three-dimensional image / cofactor / steroid receptor / nuclear receptor / イメージング / ポストレセプター / 三次元画像 / ステロイドレセプター / 核内受容体 / functional domein / TPR structure / splicing factor compartment / androgen receptor / ARAF-1 / Yeast Two-hybrid assay / 機能ドメイン / TPR配列 / スプライシングファクターコンパートメント / GST pull-down / 転写 / 不応症 / 受容体 / 睾丸性女性化症 / ELISA / KGN細胞 / アンドロゲン過敏症 / AR異常症 / 17α-hydroxylase欠損症 / NF-kB / PPARγ:RXR / FoxH1 / アンドロゲン受容体(AR) / FoxO 1 / 1IGF-1 / androgen receptor(AR) / 内分泌攪乱物質 / 肥満 / ステロイド産生細胞再生 / 間葉系幹細胞 / ステロイド産生細胞 / アロマターゼ / SF-1 / Ad4BP Less
  • Research Projects

    (7 results)
  • Research Products

    (38 results)
  • Co-Researchers

    (10 People)
  •  Basic and clinical research on abnormalities of sexual differentiation associated with synthesis and action of sex steroids

    • Principal Investigator
      YANASE Toshihiko
    • Project Period (FY)
      2004 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University
  •  The establishment of cell therapy using regenerated-adrenocortical cells tranfected by Ad4BP/SF-1 cDNA

    • Principal Investigator
      OKABE Taijiro
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      KYUSHU UNIVERSITY
  •  Detection system for post-receptor disorders by three-dimensional imaging

    • Principal Investigator
      TAKAYANAGI Ryoichi
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Endocrinology
    • Research Institution
      Kyushu University
  •  Elucidation of the mechanism of pancreas development and its application for the regenerative medicine

    • Principal Investigator
      NOMURA Masatoshi
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      Kyushu University
  •  Cloning and characterization of a novel coactivator, ANT-1, for androgen receptor AF-1 domainPrincipal Investigator

    • Principal Investigator
      GOTO Kiminobu
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      Kyushu University
  •  Cloning of androgen receptor AF-1 specific cbactivator gene and development of new drug

    • Principal Investigator
      NAWATA Hajime
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Endocrinology
    • Research Institution
      KYUSHU UNIVERSITY
  •  Establishment of new disease concept, nuclear receptor cofactor disease

    • Principal Investigator
      NAWATA Hajime
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Endocrinology
    • Research Institution
      Kyushu University

All 2007 2006 2005 2004 2003

All Journal Article

  • [Journal Article] Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and th development of pancreas islets.2007

    • Author(s)
      Goto, Y, et. al.
    • Journal Title

      Dev Dyn 236

      Pages: 2865-2874

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Modification of glucocorticoid-sensitivity by MAP kinase signaling pathways in glucocorticoid-induced T-cell apoptosis2006

    • Author(s)
      Tanaka, T., Okabe, T., Gondo, S., Fukuda, M., Yamamoto, M., Umemura, T., Tani, K., Nomura, M., Goto, K., Yanase, T., Nawata, H
    • Journal Title

      Experimental Hematology 34

      Pages: 1542-52

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor2006

    • Author(s)
      Fan, S., Goto, K., Chen, G., Morinaga, H., Nomura, M., Okabe, T., Nawata, H., Yanase, T
    • Journal Title

      Biochem Biophys Res Commum 341

      Pages: 192-201

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Modification of glucocorticoid-sensitivity by MAP kinase signaling pathways in glucocorticoid-induced T-cell apoptosis.2006

    • Author(s)
      Tanaka T, Okabe T, Gondo S, Fukuda M, Yamamoto M, Umemura T, Tani K, Nomura M, Goto K, Yanase T, Nawata H
    • Journal Title

      Experimental Hematology 34

      Pages: 1542-1552

    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor.2006

    • Author(s)
      Fan S, Goto K, Chen G, Morinaga H, Nomura M, Okabe T, Nawata H, Yanase T
    • Journal Title

      Biochem Biophys Res Commum 341

      Pages: 192-201

    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor.2005

    • Author(s)
      Fan S, Goto K, Chen G, Morinaga H, Nomura M, Okabe T, Nawata H, Yanase T
    • Journal Title

      Biochem Biophys Res Commun. 341

      Pages: 192-201

    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Androgen receptor null male mice develop late-onset obesity due to decreased energy expenditure and lypolytic activity but show normal insulin sensitivity with high adiponectin secretion2005

    • Author(s)
      Fan, W., Yanase, T., Nomura, M., Okabe, T., Goto, K., Sato T, Kawano, H., Kato, S., Nawata, H
    • Journal Title

      Diabetes 54

      Pages: 1000-1008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor.2005

    • Author(s)
      Chen G, Nomura M, Morinaga H, Matsubara E, Okabe T, Goto K, Yanase T, Zheng H, Lu J, Nawata H
    • Journal Title

      J Biol Chem. 280

      Pages: 36355-36363

    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Dehydroepiandrosterone negatively regulates the p38 mitogen-activated protein kinase pathway by a novel PTPN7 locus-derived trandscript.2005

    • Author(s)
      Ashida K, Goto K, Zhao Y, Okabe T, Yanase T, Takayanagi R, Nomura M, Nawata H
    • Journal Title

      Biochem Biophys Acta (In press)

    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Androgen receptor null male mice develop late-onset obesity due to decreased energy expenditure and lypolytic activity but show normal insulin sensitivity with high adiponectin secretion.2005

    • Author(s)
      Fan W, Yanase T, Nomura M, Okabe T, Goto K, Sato T, Kawano H, Kato S, Nawata H
    • Journal Title

      Diabetes 54

      Pages: 1000-1008

    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Activation of Peroxisome Proliferator-Actibated Receptor-γ and Retinoid X Receptor Inhibits Aromatase Tanscription via Nuclear Factor- κB2005

    • Author(s)
      Fan W, Yanase T, Wei L, Nomura M, Okabe T, Goto K, Harada N, Nawata H
    • Journal Title

      Endocrinology 146

      Pages: 85-92

    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretion.2005

    • Author(s)
      Fan W, Yanase T, Nomura M, Okabe T, Goto K, Sato T et al.
    • Journal Title

      Diabetes 54

      Pages: 1000-1008

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571067
  • [Journal Article] Dehydroepiandrosterone negatively regulates the p38 mitogen-activated protein kinase pathway by a novel PTPN7 locus-derived transcript.2005

    • Author(s)
      Ashida K, Goto K, Zhao Y, Okabe T, Yanase T, Takayanagi R, Nomura M, Nawata H
    • Journal Title

      Biochim Biophys Acta 1728

      Pages: 84-94

    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Androgen receptor null male mice develop late-onset obesity due to decreased energy expenditure and lypolytic activity but show normal insulin sensitivity with high adiponectin secretion2005

    • Author(s)
      Fan W, Yanase T, Nomura M, Okabe T, Goto K, Sato T, Kawano H, Kato S, Nawata H
    • Journal Title

      Diabetes (In press)

    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Activation of peroxisome proliferator activated receptor γand retinoid X receptor inhibits CYP19 transcription through NF-κB in ovarian granulosa cells2005

    • Author(s)
      Fan, W., Yanase, T., Wei L, Nomura, M., Okabe, T., Goto, K., Harada, N., Nawata, H
    • Journal Title

      Endocrinology 146

      Pages: 85-92

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Modulation of androgen receptor transactivation by FoxH1: A newly identified androgen receptor corepressor2005

    • Author(s)
      Chen, G., Nomura, M., Morinaga, H., Matsubara, E., Okabe, T., Goto, K., Yanase, T., Zheng, H., Lu, J., Nawata, H
    • Journal Title

      J. Biol. Chem 280

      Pages: 36355-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Activation of Peroxisome Proliferator Activated Receptor γ and Retinoid X Receptor Inhibits aromatase transcription via NF-κB2005

    • Author(s)
      Fan W, Yanase T, Morinaga H, Mu YM, Nomura M, Okabe T, Goto K, Nawata H
    • Journal Title

      Endocrinology 146

      Pages: 85-92

    • Data Source
      KAKENHI-PROJECT-14571067
  • [Journal Article] Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretion2005

    • Author(s)
      Fan W, Yanase T, Nomura M, Okabe T, Goto K, Sato T et al.
    • Journal Title

      Diabetes 54

      Pages: 1000-1008

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14571067
  • [Journal Article] Dehydroepiandrosterone negatively regulates the p38 mitogen-activated protein kinase pathway by a novel PTPN7 locus-derived transcript2005

    • Author(s)
      Ashida, K., Goto, K., Zhao, Y., Okabe, T., Yanase, T., Takayanagi, R., Nomura, M., Nawata, H
    • Journal Title

      Biochim.Biophys. Acta 1728

      Pages: 84-94

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Activation of peroxisome proliferator activated receptor γ and retinoid X receptor inhibits CYP19 transcription through NF-κB in ovarian granulosa cells.2005

    • Author(s)
      Fan W, Yanase T, Wei L, Nomura M, Okabe T, Goto K, Harada N, Nawata H
    • Journal Title

      Endocrinology 146

      Pages: 85-92

    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] A benzimidazole fungicide, benomyl and its metabolite carbendazim induce aromatase activity in human ovarian granulose-like tumor cell line(KGN)2004

    • Author(s)
      Morinaga, H., Yanase, T., Nomura, M., Okabe, T., Goto, K., Harada, N., Nawata,H
    • Journal Title

      Endocrinology 145

      Pages: 1860-1869

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Coregulator-related diseases2004

    • Author(s)
      Yanase T, Adachi M, Goto K, Takayanagi R, Nawata H
    • Journal Title

      Intern Med 43

      Pages: 368-373

    • NAID

      10013090874

    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] SF-1/Ad4BP Transforms primary long-term cultured bone marrow cells into ACTH-responsive steroidogenic cells2004

    • Author(s)
      Gondo S, Yanase T, Okabe T, Tanaka T, Morinaga H, Nomura M, Goto K, Nawata H
    • Journal Title

      Genes to Cells 9

      Pages: 1239-1247

    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Protein kinase A potentiates Ad4BP/SF-1 transactivation by re-integrating the subcellular dynamic interactions of the nuclear receptor with its cofactors2004

    • Author(s)
      Fan, W., Yanase, T., Yin, W., Kawate, H., Saitoh, M., Oba, K., Nomura, M., Okabe, T., Goto, K., Yanagisawa, J., Kato, S., Takayanagi, R., Nawata, H
    • Journal Title

      GCN5/TRRAP and suppressor, DAX-1: alaser confocal imaging study in living KGN cells. Mol. Endocrinol 18

      Pages: 127-141

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] SF-1/Ad4BP transforms primary long-term cultured bone marrow cells into ACTH-responsive steroidogenic cells2004

    • Author(s)
      Gondo, S., Yanase, T., Okabe, T., Tanaka, T., Morinaga, H., Nomura, M., Goto, K., Nawata, H
    • Journal Title

      Genes to Cells 9

      Pages: 1239-1247

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Protein kinase A potentiates Ad4BP/SF-1 transactivation by re- integrating the subcellular dynamic interactions of the nuclear receptor with its cofactors, GCN5-TRRAP, and suppressor, DAX-1 : a laserconfocal imaging study in living KGN cells2004

    • Author(s)
      Fan W, Yanase T, Yin W, Kawate H, Saitoh M, Oba K, Nomura M, Okabe T, Goto K, Yanagisawa J, Kato S, Takayanagi R, Nawata H
    • Journal Title

      Mol Endocrinol 18

      Pages: 127-141

    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] A Benzimidazole Fungicide, Benomyl and Its Metabolite Carbendazim Induce Aromatase Activity in Human Ovarian Granulose-Like Tumor Cell Line (KGN).2004

    • Author(s)
      Morinaga H, Yanase T, Nomura M, Okabe T, Goto K, Harada N et al.
    • Journal Title

      Endocrinology 145

      Pages: 1860-1869

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14571067
  • [Journal Article] A Benzimidazole Fungicide, Benomyl and Its Metabolite Carbendazim Induce Aromatase Activity in Human Ovarian2004

    • Author(s)
      Morinaga H, Yanase T, Nomura M, Okabe T, Goto K, Harada N
    • Journal Title

      Endocrinology 145

      Pages: 1860-1869

    • Data Source
      KAKENHI-PROJECT-16086207
  • [Journal Article] Aromatase in bone: roles of Vitamin D3 and androgens.2003

    • Author(s)
      Yanase, T., Suzuki, S., Goto, K., Nomura, M., Okabe, T., Takayanagi, R., Nawata, H.
    • Journal Title

      J Steroid Biochem Mol Biol 86

      Pages: 393-397

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13357010
  • [Journal Article] Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells.2003

    • Author(s)
      Mukasa, C., Nomura, M., Tanaka, T., Tanaka, K., Nishi, Y., Okabe, T., Goto, K., Yanase, T., Nawata, H.
    • Journal Title

      Endocrinology 144

      Pages: 1603-1611

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13357010
  • [Journal Article] Human pituitary tumor transforming gene (hPTTG) inhibits human lung cancer A549 cell growth through activation of p21(WAF1/CIP1 ).2003

    • Author(s)
      Mu, YM., Oba, K., Yanase, T., Ito, T., Ashida, K., Goto, K., Morinaga, H., Ikuyama, S., Takayanagi R, Nawata H.
    • Journal Title

      Endocr J. 50

      Pages: 771-781

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13357010
  • [Journal Article] Activation function-1 domain of androgen receptor contributes to the interaction between two distinct subnuclear compartments.2003

    • Author(s)
      Goto K.et al.
    • Journal Title

      J Steroid Biochem Mol Biol. 85

      Pages: 201-208

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14571068
  • [Journal Article] Functional characterization of a new human Ad4BP/SF-1 variation, G146A.2003

    • Author(s)
      WuQiang F., Yanase T., Wei L., Oba, K., Nomura M., Okabe T, Goto, K., Nawata, H.
    • Journal Title

      Biochem Biophys Res Commun 311

      Pages: 987-994

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13357010
  • [Journal Article] Activation function-1 domain of androgen receptor contributes to the interaction between two distinct subnuclear compartments.2003

    • Author(s)
      Goto K, Zhao Y, Saito M, Tomura A, Morinaga H, Nomura M, Okabe T, Yanase T, Takayanagi, R., Nawata, H.
    • Journal Title

      J Steroid Biochem Mol Biol 85

      Pages: 201-208

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13357010
  • [Journal Article] Aromatase in bone : roles of Vitamin D3 and androgens.2003

    • Author(s)
      Yanase, T., Suzuki, S., Goto, K., Nomura, M., Okabe, T., Takayanagi, R., Nawata, H.
    • Journal Title

      J Steroid Biochem Mol Biol 86

      Pages: 393-397

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13357010
  • [Journal Article] Activation function-1 domain of androgen receptor contributes to the interaction between two distinct subnuclear compartments.2003

    • Author(s)
      Goto K et al.
    • Journal Title

      J Steroid Biochem Mol Biol 85

      Pages: 201-208

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370330
  • [Journal Article] Human pituitary tumor transforming gene (hPTTG) inhibits human lung cancer A549 cell growth through activation of p21 (WAF1/CIP1).2003

    • Author(s)
      Mu, YM., Oba, K., Yanase, T., Ito, T., Ashida, K., Goto, K., Morinaga, H., Ikuyama, S., Takayanagi R, Nawata H.
    • Journal Title

      Endocr J. 50

      Pages: 771-781

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13357010
  • [Journal Article] Functional characterization of a new human Ad4BP/SF-1 variation, G146A.2003

    • Author(s)
      WuQiang F., Yanase T., Wei L., Oba, K., Nomura M,.Okabe T, Goto, K., Nawata, H.
    • Journal Title

      Biochem Biophys Res Commun. 311

      Pages: 987-994

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13357010
  • 1.  OKABE Taijiro (40264030)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 32 results
  • 2.  NOMURA Masatoshi (30315080)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 32 results
  • 3.  NAWATA Hajime (10038820)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 31 results
  • 4.  YANASE Toshihiko (30239818)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 35 results
  • 5.  TAKAYANAGI Ryoichi (30154917)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 6.  OHNAKA Keizo (30325518)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KAWATE Hisaya (20336027)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  大江 賢治 (30419527)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  名和田 新 (10038200)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  戸村 有宏
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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