FUJISHIMA TOSHIE 藤島利江

… Alternative Names

藤島利江フジシマトシエ

Fujishima Toshie 藤島利江

FUJISHIMA Toshie 藤島利江

FUJISHIMA Tosie 藤島利江

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Researcher Number	90286980
Other IDs
External Links
Affiliation (Current)	2025: 帝京大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 徳島文理大学, 薬学部, 教授 2016 – 2019: 徳島文理大学, 薬学部, 教授 2011 – 2013: 徳島文理大学, 薬学部, 准教授 2007: Tokushima Bunri University, 香川薬学部, 准教授 2004 – 2006: 徳島文理大学, 香川薬学部, 助教授 2002 – 2003: Teikyo University Faculty of Pharmaceutical Sciences, Lecturer, 薬学部, 講師 1997 – 2001: 帝京大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical pharmacy Except Principal Investigator Chemical pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Chemical pharmacy
Keywords	Principal Investigator 核内受容体 / ビタミンD / 化学合成 / ビタミンDレセプター / ステロイド / ホルモン / ビタミン / カルシトリオール / A環 / 合成 … More / 複素環 / ビタミンD受容体 / オリゴDNA / アンダゴニスト / 遺伝子転写因子 / アンタゴニスト / カルシトルリオール … More Except Principal Investigator TEI-9647 / 活性型ビタミンD_3 / NFκB / 構造活性相関 / ビタミンD活性 / シナプス / 脳 / カルシウム / Spine apparatus / リアノジン受容体 / phencyclidine / アクチン / CapZ / スパイン / シナプス可塑性 / Arc / c-Fos / 回路 / 神経細胞 / 認知 / 可塑性 / Engram / 記憶 / structure activity relationship / HL-60 cells / Paget's disease / agonist / antagonist / active vitamin D_3 / vitamin D receptor (VDR) / HL-60細胞 / Paget's骨病 / アゴニスト / アンタゴニスト / ビタミンDレセプター(VDR) / super agonist / active vitamin D3 / nuclear receptor / Schiff base / oligonucleotides / gene recombination enzyme / RecA Protein / ホルミルウリジン / 凝集 / ゲル電気泳動 / CDスペクトル / スーパーアゴニスト / 核内受容体 / シッフ塩基 / オリゴヌクレオチド / 遺伝子組換え酵素 / RecA蛋白 / Furansulfolene / Chemical utilization of sugars / Structure-activity relationship / Stereoselective synthesis / Conformation analysis / HL-60 cell differentiation / Vitamin D receptor / A-Ring modified vitamin D / フラン縮環3-スルホレン / 合成 / コンホメーション / 活性型ビタミンD / 糖の利用 / リガンド・レセプター複合体 / HL-60細胞分化誘導 / ビタミンDレセプター / フランスルホレン / 糖の化学的利用 / 立体選択的合成 / コンホメーション解析 / HL-60細胞分化誘導能 / ビタミンD レセプター / A環修飾ビタミンD / Vitamin D Receptor Affinity / Potency of HL-60 Differientiation / Conformation Analysis / Synthesis of Active Vitamin D Derivatives / Mass Spectrometry / Peptide / Neuro-venom / Solitary Wasp / デイールス・アルダー反応 / 縮環スルホレン / 電解酸化 / ビタミンD誘導体合成 / ビタミンDレセプター結合能 / HL-60分化誘導能 / 立体配座解析 / 活性型ビタミンDの合成 / マススペクトロメトリー / ペプチド / 神経毒 / 独居性狩蜂 Less

Activity/psychosis-dependent molecular plasticity around synapses in vivo
- Principal Investigator
  
  山田麻紀
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tokushima Bunri University
Synthesis and characterization of novel seco-steroid analogues bearing small cyclic ethers instead of the hydroxy groupsPrincipal Investigator
- Principal Investigator
  
  Fujishima Toshie
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokushima Bunri University
Design and synthesis of novel vitamin D receptor ligands having a functional group that reinforces the interaction with the receptorPrincipal Investigator
- Principal Investigator
  
  FUJISHIMA Toshie
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokushima Bunri University
核内受容体モジュレータの合成,及び遺伝子特異的な活性化能の検討Principal Investigator
- Principal Investigator
  
  藤島利江
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokushima Bunri University
ビタミンD受容体モジュレータのデザインと合成Principal Investigator
- Principal Investigator
  
  藤島利江
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokushima Bunri University
Design and Synthesis of Vitamin D Receptor Antagonists : Remedy for Pagets Desease
- Principal Investigator
  
  KITTAKA Atsushi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
DMA Lesions on the Specific Site in the Transcription Factor Binding Domain with RecA-Oligonucleotide Complexes
- Principal Investigator
  
  KITTAKA Atsushi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
A環アナログから探る活性型ビタミンDの作用メカニズムPrincipal Investigator
- Principal Investigator
  
  藤島利江
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
Organic Chemical Creation of Substances with Novel Function and Its Application
- Principal Investigator
  
  TAKAYAMA Hiroaki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
A環修飾ビタミンD誘導体の合成とその生理作用Principal Investigator
- Principal Investigator
  
  藤島利江
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
Organic Chemical Investigation of Novel Biologically Active Compounds, Syntheses and Reactions, Evaluation of Biological Activities.
- Principal Investigator
  
  TAKAYAMA Hiroaki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University

[Journal Article] Design and concise synthesis of novel vitamin D analogues bearing a functionalized aromatic ring on the side chain2019
- Author(s)
  Fujishima Toshie、Komatsu Takuro、Takao Yuri、Yonamine Wataru、Suenaga Tsutomu、Isono Hiroaki、Morikawa Masayuki、Takaguchi Keisuke
- Journal Title
  
  Tetrahedron
  
  Volume: 75 Issue: 8 Pages: 1098-1106
- DOI
  10.1016/j.tet.2019.01.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08337
[Journal Article] 新しい生物学的等価体としてのオキセタン2018
- Author(s)
  藤島利江
- Journal Title
  
  化学と生物
  
  Volume: 56 Pages: 589-590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08337
[Journal Article] Concise synthesis and characterization of novel seco-steroids bearing a spiro-oxetane instead of a metabolically labile C3-hydroxy group2014
- Author(s)
  Toshie Fujishima, Tsutomu Suenaga, Takato Nozaki
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: **
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590142
[Journal Article] Probing a water channel near the A-ring of receptor-bound 1α,25-dihydroxyvitamin D_3 with selected 2α-substituted analogues.2006
- Author(s)
  Hourai, S., Fujishima, T., Kittaka, A., Suhara Y., Takayama, H., Rochel, N., Moras.D.
- Journal Title
  
  J. Med. Chem. 49・17
  
  Pages: 5199-5205
- Data Source
  KAKENHI-PROJECT-18790095
[Journal Article] Methyl-introduced A-ring analogues of 1α,25-dihydroxyvitamin D_3 : Synthesis and biological evaluation.2006
- Author(s)
  Fujishima, T., Tsutsumi, R., Negishi, Y., Fujii, S., Takayama, H., Kittaka, A., Kurihara, M.
- Journal Title
  
  Anticancer Research 26・4A
  
  Pages: 2633-2626
- Data Source
  KAKENHI-PROJECT-18790095
[Journal Article] Design, synthesis and biological evaluation of novel 1α,25-dihydroxyvitamin D3 analogues possessing aromatic ring on 2α-position2005
- Author(s)
  S.Honzawa, K.Hirasaka, Y.Yamamoto, S.Peleg, T.Fujishima, M.Kurihara, N.Saito, S.Kishimoto, T.Sugiura, K.Waku, H.Takayama, A.Kittaka
- Journal Title
  
  Tetrahedron 61・47
  
  Pages: 11253-11263
- Data Source
  KAKENHI-PROJECT-16790086
[Journal Article] The antagonism between 2-methyl-1,25-dihydroxyvitamin D3 and 2-methyl-20-epi-1,25-dihydroxyvitamin D3 in non-genomic pathway-mediated biological responses induced by 1α,25-dihydroxyvitamin D3 assessed by NB4 cell differentiation2005
- Author(s)
  D.Miura, A.W.Norman, M T.Mizwicki, T.Fujishima, K.Konno, A.Kittaka, H.Takayama, S.Ishizuka
- Journal Title
  
  Journal of Steroid Biochemistry and Molecular Biology 94・5
  
  Pages: 469-479
- Data Source
  KAKENHI-PROJECT-16790086
[Journal Article] Metabolism of 2α-propoxy-1α,25-dihydroxyvitamin D3 and 2α-(3-hydroxypropoxy)-1α,25-dihydroxyvitamin D3 by human CYP27A1 and CYP24A12005
- Author(s)
  D.Abe, T.Sakaki, T.Kusudo, A.Kittaka, N.Saito, Y.Suhara, T.Fujishima, H.Takayama, H.Hamamoto, M.Kamakura, M.Ohta, E.Inouye
- Journal Title
  
  Drug Metabolism and Disposition 33・6
  
  Pages: 778-784
- Data Source
  KAKENHI-PROJECT-16790086
[Journal Article] Design and Efficient Synthesis of 2α-(ω-Hydroxyalkoxy)-1α,25-dihydroxyvitamin D3 Analogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell2004
- Author(s)
  Saito Nozomi, Suhara Yoshitomo, Kurihara Masaaki, Fujishima Toshie, Honzawa Shinobu, Takayanagi Hitoshi, Kozono Toshiro, Matsumoto Masahiko
- Journal Title
  
  Journal of Organic Chemistry 69(22)
  
  Pages: 7463-7471
- Data Source
  KAKENHI-PROJECT-16790086
[Journal Article] Synthesis of Novel 1α, 25-Dihydroxy-19-norvitamin D_3 with an Amide Conjugate2004
- Author(s)
  Yoshitomo Suhara, Keiichiro Ono, Akihiro Yoshida, Toshie Fujishima, Nozomi Saito, Shinobu Honzawa, Seishi Kishimoto, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Heterocycles 62(1)
  
  Pages: 423-436
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Metabolism of A-ring diastereomers of 1α,25-dihydroxyvitamin D3 by CYP24Al2004
- Author(s)
  Kusudo Tatsuya, Sakaki Toshiyuki, Abe Daisuke, Fujishima Toshie, Kittaka Atsushi, Takayama Hiroaki, Hatakeyama Susumi, Ohta Miho, Inouye Kuniyo
- Journal Title
  
  Biochemical and Biophysical Research Communications 321(4)
  
  Pages: 774-782
- Data Source
  KAKENHI-PROJECT-16790086
[Journal Article] 2,2-Functionalized analogues of 1α,25-dihydroxyvitamin D3, the potent inducers of cell differentiation2004
- Author(s)
  Fujishima Toshie, Kittaka Atsushi, Kurihara Masaaki, Saito Nozomi, Honzawa Shinobu, Kishimoto Seishi, Sugiura Takayuki, Waku Keizo, Takayama Hiroaki
- Journal Title
  
  Journal of Steroid Biochemistry and Molecular Biology 89-91(1-5)
  
  Pages: 89-92
- Data Source
  KAKENHI-PROJECT-16790086
[Journal Article] Design and Efficient Synthesis of 2α-(ω-Hydroxyalkoxy)-lα, 25-dihydroxyvitamin D_3 Including 2-epi-ED-71 and Its 20-Epimers with HL-60 Cell Differentiation Activity2004
- Author(s)
  Nozomi Saito, Yoshitomo Suhara, Masaaki Kurihara, Toshie Fujishima, Shinobu Honzawa, Hitoshi Takayanagi, Toshiro Kozono, Masahiko Matsumoto, Masayuki Ohmori, Naoki Miyata, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  J Org.Chem. 69(22)
  
  Pages: 7463-7471
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] 2,2-Functionalized Analogues of 1α,25-Dihydroxyvitamin D_3,The Potent Inducers of Cell Differentiation2004
- Author(s)
  Toshie Fujishima, et al.
- Journal Title
  
  Journal of Steroid Biochemistry & Molecular Biology 89-90巻
  
  Pages: 89-92
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] 2,2-Functionalized Analogues of 1α, 25-Dihydroxyvitamin D_3, The Potent Inducers of Cell Differentiation2004
- Author(s)
  Toshie Fujishima, Atsushi Kittaka, Masaaki Kurihara, Nozomi Saito, Shinobu Honzawa, Seishi Kishimoto, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama
- Journal Title
  
  J.Steroid Biochem.Mol.Biol. 89-90 (May)
  
  Pages: 89-92
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] 2,2-Functionalized Analogues of 1α,25-Dihydroxyvitamin D_3, The Potent Inducers of Cell Differentiation2004
- Author(s)
  Toshie Fujishima, et al.
- Journal Title
  
  Journal of Steroid Biochemistry & Molecular Biology 89-90巻
  
  Pages: 89-92
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Metabolism of A-Ring Diastereomers of 1α, 25-Dihydroxyvitamin D_3 by CYP24A12004
- Author(s)
  Tatsuya Kusudo, Toshiyuki Sakaki, Daisuke Abe, Toshie Fujishima, Atsushi Kittaka, Hiroaki Takayama, Susumi Hatakeyama, Miho Ohta, Kuniyo Inouye
- Journal Title
  
  Biochem.Biophys.Res.Commun 321 (4)
  
  Pages: 774-782
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Synthesis of novel 1α,25-dihydroxy-19-norvitamin D3 with an amide conjugate2004
- Author(s)
  Suhara Yoshitomo, Ono Keiichiro, Yoshida Akihiro, Fujishima Toshie, Saito Nozomi, Honzawa Shinobu, Kishimoto Seishi, Sugiura Takayuki, Waku Keizo
- Journal Title
  
  Heterocycles 62
  
  Pages: 423-436
- Data Source
  KAKENHI-PROJECT-16790086
[Journal Article] Synthesis of 2,2-Dimethyl-1,25-dihydroxyvitamin D_3 : A-Ring Structural Motif that Modulates Interactions of Vitamin D Receptor with Transcriptional Coactivators2003
- Author(s)
  Toshie Fujishima, Atsushi Kittaka, Kazuyoshi Yamaoka, Ken-ichi Takeyama, Shigeaki Kato, Hiroaki Takayama
- Journal Title
  
  Org.Biomol.Chem. 1(11)
  
  Pages: 1863-1869
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Design and Synthesis of Potent Vitamin D Receptor Antagonists with A-Ring Mosifications : Remarkable Effects of 2α-Methyl Introduction on Antagonistic Activity2003
- Author(s)
  Toshie Fujishima, et al.
- Journal Title
  
  Bioorganic and Medicinal Chemistry 11巻・17号
  
  Pages: 3621-3631
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Synthesis of 2-Modified 1α,25-Dihydroxy-19-norvitamin D_3 with Julia Olefination: High Potency in Induction of Differentiation on HL-60 Cells2003
- Author(s)
  Keiichiro Ono, Akihiro Yoshida, Nozomi Saito, Toshie Fujishima, Shinobu Honzawa, Yoshitomo Suhara, Seishi Kishimoto, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  J.Org.Chem. 68(19)
  
  Pages: 7407-7415
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Metabolism of 20-Epimer of 1α,25-Dihydroxyvitamin D_3 by CYP24 : Species-based Difference between Humans and Rats2003
- Author(s)
  Tatsuya Kusudo, Toshiyuki Sakaki, Abe Daisuke, Toshie Fujishima, Atsushi Kittaka, Hiroaki Takayama, Miho Ohta, Kuniyo Inoue
- Journal Title
  
  Biochem.Biophys.Res.Commun. 309(4)
  
  Pages: 885-892
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Dramatic Enhancement of Antagonistic Activity on Vitamin D Receptor : A Double Functionalization of 1α-Hydroxyvitamin D3-26,23-Lactones2003
- Author(s)
  Nozomi Saito, Hiroshi Saito, Miyuki Anzai, Kazuya Takenouchi, Daishiro Miura, Seiichi Ishizuka, Toshie Fujishima, Akihiro Yoshida, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Org.Lett. 5 (25)
  
  Pages: 4859-4862
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Synthesis of 2,2-Dimethyl-1,25-dihydroxyvitamin D_3 :A-Ring Structural Motif that Modulates Interactions of Vitamin D Receptor with Transcriptional Coactivators2003
- Author(s)
  Toshie Fujishima, et al.
- Journal Title
  
  Organic & Biomolecular Chemistry 1巻・11号
  
  Pages: 1863-1869
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Concise Synthesis and Biological Activities of 2α-Alkyl-and 2α-(ω-Hydroxyalkyl)-20-epi-1α,25-Dihydroxyvitamin D_32003
- Author(s)
  Shinobu Honzawa, Yoshitomo Suhara, Ken-ichi Nihei, Nozomi Saito, Seishi Kishimoto, Toshie Fujishima, Masaaki Kurihara, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Bioorg.Med.Chem.Lett. 13(20)
  
  Pages: 3503-3506
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Remarkable Effect of 2α-Modification on the VDR Antagonistic Activity of 1α-Hydroxyvitamin D_3-26,23-Lactones2003
- Author(s)
  Nozomi Saito, Toshihiro Matsunaga, Toshie Fujishima, Miyuki Anzai, Hiroshi Saito, Kazuya Takenouchi, Daishiro Miura, Seiichi Ishizuka, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Org.Biomol.Chem. 1(24)
  
  Pages: 4396-4402
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Design, Synthesis, and Biological Studies of the A-Ring Modified 1,25-Dihydroxyvitamin D_3 Analogs2003
- Author(s)
  Hiroaki Takayama, Atsushi Kittaka, Toshie Fujishima, Yoshitomo Suhara
- Journal Title
  
  Recent Results in Cancer Research Vol. 164, Vitamin D analogs in cancer prevention and therapy (Reichrath J.,Fridrich M.,Tilgen W.Eds.) (Springer-Verlag : Berlin Heidelberg, Germany)
  
  Pages: 289-317
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Design and Synthesis of Potent Vitamin D Receptor Antagonists with A-Ring Modifications : Remarkable Effects of 2α-Methyl Introduction on Antagonistic Activity2003
- Author(s)
  Toshie Fujishima, Yoshinori Kojima, Isao Azumaya, Atsushi Kittaka, Hiroaki Takayama
- Journal Title
  
  Bioorg.Med.Chem. 11(17)
  
  Pages: 3621-3631
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Patent] Vitamin D3 lactone derivatives for treatment of osteoporosis2004
- Inventor(s)
  K.Yamana, Y.Harada, Y.Azuma, H.Saito, K.Takenouchi, H.Takayama, A.Kittaka, N.Saito, T.Fujishima
- Industrial Property Rights Holder
  Teijin Pharma Co., Ltd, Japan
- Filing Date
  2004-08-04
- Acquisition Date
  2006-02-16
- Data Source
  KAKENHI-PROJECT-16790086
[Patent] Vitamin D3 Lactone Derivertive2004
- Inventor(s)
  Takenouchi Kazuyo, Anzai Miyuki, Sato Hiroshi, Okada Kasuhisa, Ishizuka Seiichi, Miura Daishiro, Takayama Hiroaki, Kittaka Atsushi, Saito Nozomi, Fujishima Toshie
- Industrial Property Rights Holder
  TEIJIN PHARMA LTD
- Filing Date
  2004-01-29
- Acquisition Date
  2004-08-12
- Data Source
  KAKENHI-PROJECT-16790086
[Presentation] 生体内における樹状突起スパインでの分子可塑性2022
- Author(s)
  山田麻紀、久保山和哉、窪田剛志、吉岡美紅、中谷音葉、藤島利江、足達俊吾、夏目徹
- Organizer
  Neuro2022（日本神経科学学会・日本神経化学会・日本神経回路学会合同学会（ポスター発表）
- Data Source
  KAKENHI-PROJECT-21K06541
[Presentation] パラジウムを用いたビタミン D3とその誘導体に対する幾何異性化反応の解析2020
- Author(s)
  森川雅行，河野夏美，藤島利江
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] 側鎖22位に特徴的なエキソメチレンを有するビタミン D誘導体の合成研究2020
- Author(s)
  佐竹寿弥，末長努，六車佳菜子，森川雅行，藤島利江
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] ビタミンD及びその関連化合物における幾何異性化反応の解析2019
- Author(s)
  森川雅行，河野夏美，藤島利江
- Organizer
  日本薬学会　第139年会
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] 官能基化された芳香環を有するビタミンD誘導体の設計と合成2019
- Author(s)
  藤島利江，小松卓朗，高尾百合，与那嶺渡，末長努，礒野宏章，森川雅行，高口圭輔
- Organizer
  日本薬学会　第139年会
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] 19位ホモ型ビタミンD誘導体の合成研究2019
- Author(s)
  藤島利江，和田敦規，森川雅行，宇根霞
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] CONCISE SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL VITAMIN D ANALOGUES BEARING A FUNCTIONALIZED AROMATIC RING ON THE SIDE CHAIN2019
- Author(s)
  T. Fujishima, T. Komatsu, Y. Takao, W. Yonamine, T. Suenega, H. Isono, M. Morikawa, K. Takaguchi
- Organizer
  The 22nd Vitamin D Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] ビタミンD3およびその誘導体の幾何異性化反応の解析2019
- Author(s)
  森川雅行，河野夏美，藤島利江
- Organizer
  第58回日本薬学会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] 側鎖22位に特徴的なエキソメチレンを有するビタミンD誘導体の合成研究2019
- Author(s)
  佐竹寿弥，末長努，六車佳菜子、森川雅行，村尾聡史，藤島利江
- Organizer
  第58回日本薬学会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] Synthesis and biological evaluation of Novel 20-hydroxyvitamin D analogues with cleaved side-chain2018
- Author(s)
  Toshie Fujishima, Tsutomu Suenaga, Maki Yamasuge, Syota Onishi, Masatoshi Kawahata, Kentaro Yamaguchi
- Organizer
  The 21st Vitamin D Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] A環にオキセタンを有するビタミンD誘導体の合成2018
- Author(s)
  藤島利江，末長努，野崎孝徒，川幡正俊，山口健太郎
- Organizer
  第4回Neo vitamin D workshop
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] ビタミンD及びその関連化合物における幾何異性化反応の解析2018
- Author(s)
  森川雅行，河野夏美，藤島利江
- Organizer
  日本薬学会　第１３８年会
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] Incorporation of a spiro-oxetane into the A-ring of vitamin D: Design and syntheses of 1,25-dihydroxyvitamin D analogues bearing an additional ring instead of the hydroxy groups2017
- Author(s)
  Toshie Fujishima, Tsutomu Suenaga, Takato Nozaki
- Organizer
  The 18th Tetrahedron Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] A環1位，2位，3位に対称なスピロオキセタン構造を有する新規ビタミンD3誘導体の設計と合成2016
- Author(s)
  末長努，藤島利江，川幡正俊，山口健太郎
- Organizer
  日本ビタミン学会　第68回大会
- Place of Presentation
  富山
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] スピロオキセタン構造を有するビタミンD受容体リガンドの合成2016
- Author(s)
  藤島利江，末長努，川幡正俊，山口健太郎
- Organizer
  第27回日本レチノイド研究会学術集会
- Place of Presentation
  東京
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] A環部に小員環エーテル構造を導入した新規セコステロイドの合成と構造決定2016
- Author(s)
  藤島利江，末長努，野崎孝徒，川幡正俊，山口健太郎
- Organizer
  第58回天然有機化合物討論会
- Place of Presentation
  仙台
- Year and Date
  2016-09-14
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] 側鎖部に官能基化された芳香環を有する新規ビタミンD誘導体の合成研究2016
- Author(s)
  小松卓朗，礒野宏章，与那嶺渡，高尾百合，高口圭輔，末長努，藤島利江
- Organizer
  日本ビタミン学会　第68回大会
- Place of Presentation
  富山
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] 側鎖切断型20位ヒドロキシビタミンD誘導体の合成と活性2016
- Author(s)
  藤島利江，大西翔太，山菅真基，末長努，川幡正俊，山口健太郎
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  筑波
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K08337
[Presentation] A環にスピロオキセタン構造を有する活性型ビタミンD3誘導体の合成2014
- Author(s)
  末長努,藤島利江
- Organizer
  日本薬学会第134年会
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] A環にスピロオキセタン構造を有する活性型ビタミンD3誘導体の合成2014
- Author(s)
  末長努，藤島利江
- Organizer
  日本薬学会　第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] 側鎖切断型20位ヒドロキシビタミンDの合成研究2013
- Author(s)
  末長努，山菅真基，大西翔太，川幡正俊，山口健太郎，藤島利江
- Organizer
  日本農芸化学関西・中四国・西日本支部および日本ビタミン学会近畿・中国四国・九州沖縄地区合同大会　2013年度　合同広島大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] 2位にオキセタンを有する活性型ビタミンD3誘導体の合成と生物活性2013
- Author(s)
  藤島利江,野崎孝徒
- Organizer
  日本薬学会第133年会
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] A環2位にオキセタンを有する活性型ビタミンD3誘導体の合成と生物活性2013
- Author(s)
  藤島利江，野崎孝徒
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] Incorporation of a spiro-oxetane into the A-ring of vitamin D: Design and syntheses of 1,25-dihydroxyvitamin D3 analogues bearing an additional ring fused in the A-ring2013
- Author(s)
  Toshie Fujishima, Tsutomu Suenaga, Takato Nozaki
- Organizer
  The 9th AFMC international medicinal chemistry symposium
- Place of Presentation
  台北
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] 20-ヒドロキシビタミンD3誘導体の合成研究2013
- Author(s)
  藤島利江，末長努，山菅真基，大西翔太，川幡正俊，山口健太郎
- Organizer
  日本ビタミン学会　第65回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] 20-ヒドロキシビタミンD3誘導体の合成研究2013
- Author(s)
  藤島利江,末長努,山菅真基,大西翔太,川幡正俊,山口健太郎
- Organizer
  日本ビタミン学会第65回大会
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] 25-ヒドロキシビタミンD誘導体のデザインと合成2012
- Author(s)
  藤島利江,白石敏幸,末長努
- Organizer
  第30回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] 20位水酸化ビタミンD3誘導体の合成研究2012
- Author(s)
  末長　努，大西　翔太，藤島　利江，川幡　正俊，山口　健太郎
- Organizer
  日本ビタミン学会　第64回大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] 25-ヒドロキシビタミンD誘導体のデザインと合成2012
- Author(s)
  藤島　利江，白石　敏幸，末長　努
- Organizer
  第30回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] A環部にオキセタンを有する活性型ビタミンD3誘導体の合成2012
- Author(s)
  野崎孝徒，藤島利江
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] 20位水酸化ビタミンD3誘導体の合成と生理活性2012
- Author(s)
  末長努，藤島利江
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] Novel vitamin D receptor ligands having a carboxyl group as a possible anchor to the crucial arginine residue in the ligand-binding domain2011
- Author(s)
  Fujishima, T., Shiraishi, T., Suenaga, T.
- Organizer
  The 8th AFMC medicinal chemistry symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] Novel vitamin D receptor ligands having a carboxyl group as a possible anchor to the crucial arginine residue in the ligand-binding domain.2011
- Author(s)
  Fujishima, T., Shiraishi, T., Suenaga, T., Nozaki, T., Kitamura, A.
- Organizer
  The 4th symposium vitamin D and analogs in cancer prevention and therapy
- Place of Presentation
  Homburg/Saar
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] Novel vitamin D receptor ligands having a carboxyl group as a possible anchor to the crucial arginine residue in the ligand-binding domain2011
- Author(s)
  Toshie Fujishima, Toshiyuki Shiraishi, Tsutomu Suenaga
- Organizer
  The 8^<th> AFMC international medicinal chemistry symposium
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] 20位水酸化ビタミンD3誘導体の合成研究2011
- Author(s)
  末長努，藤島利江
- Organizer
  日本ビタミン学会第63回大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23590142
[Presentation] カルボキシル基を有するビタミンD誘導体の合成研究2008
- Author(s)
  藤島利江
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜市(神奈川県)
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-18790095
[]
[]
[]
[]

1. KITSUTAKA Atsushi (00214833)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
2. SUHARA Yoshitomo (30297171)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. NOZOMI Saito (80349258)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. TAKAYAMA Hiroaki (00012609)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YOSHIDA Akihiro (10292301)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SUGIYAMA Toru (40242036)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SUZUKI Takayoshi (10119589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KONNO Katsuhiro (40215471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HONZAWA Shinobu (90311547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. ARAI Midori (40373261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山田麻紀 (00312281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

FUJISHIMA TOSHIE 藤島 利江

藤島 利江 フジシマ トシエ

Fujishima Toshie 藤島 利江

FUJISHIMA Toshie 藤島 利江

FUJISHIMA Tosie 藤島 利江

Research Projects

Research Products

Co-Researchers

Activity/psychosis-dependent molecular plasticity around synapses in vivo

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Synthesis and characterization of novel seco-steroid analogues bearing small cyclic ethers instead of the hydroxy groupsPrincipal Investigator

Principal Investigator

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Research Institution

Design and synthesis of novel vitamin D receptor ligands having a functional group that reinforces the interaction with the receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

核内受容体モジュレータの合成,及び遺伝子特異的な活性化能の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ビタミンD受容体モジュレータのデザインと合成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design and Synthesis of Vitamin D Receptor Antagonists : Remedy for Pagets Desease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DMA Lesions on the Specific Site in the Transcription Factor Binding Domain with RecA-Oligonucleotide Complexes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A環アナログから探る活性型ビタミンDの作用メカニズムPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Organic Chemical Creation of Substances with Novel Function and Its Application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A環修飾ビタミンD誘導体の合成とその生理作用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Organic Chemical Investigation of Novel Biologically Active Compounds, Syntheses and Reactions, Evaluation of Biological Activities.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Design and concise synthesis of novel vitamin D analogues bearing a functionalized aromatic ring on the side chain2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 新しい生物学的等価体としてのオキセタン2018

FUJISHIMA TOSHIE 藤島利江

藤島利江フジシマトシエ

Fujishima Toshie 藤島利江

FUJISHIMA Toshie 藤島利江

FUJISHIMA Tosie 藤島利江