DOYU Manabu 道勇学

… Alternative Names

道勇学ドウユウマナブ

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Researcher Number	90293703
Other IDs
External Links
Affiliation (Current)	2022: 愛知医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2022: 愛知医科大学, 医学部, 教授 2019 – 2020: 愛知医科大学, 医学部, 教授 2015 – 2016: 愛知医科大学, 医学部, 教授 2008: 愛知医科大学, 医学部, 教授 2007: 愛知医科大学, 医学部, 特任教授 … More 2006: Aichi Medical University, School of Medicine, Professor, 医学部, 教授 2004 – 2005: Nagoya University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 2004 – 2005: Nagoya Univesity, Department of Neurology, Assistant Professor, 大学院医学系研究科, 助教授 2002 – 2003: 名古屋大学, 大学院・医学系研究科, 講師 2001: 名古屋大学, 大学院・医学研究科, 教授 2001: Graduate School of Medicine, Nagoya University, Assistant Professor, 大学院・医学研究科, 講師 1998 – 2000: 名古屋大学, 医学部, 講師 1998: 名古屋大学, 医学部・名古屋大学, 講師 Less
Review Section/Research Field	Principal Investigator Neurology / Neurology / Basic Section 52020:Neurology-related Except Principal Investigator Neurology / Biological Sciences / Neurology / Ophthalmology / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 52020:Neurology-related
Keywords	Principal Investigator 球脊髄性筋萎縮症 / Dorfin / 筋萎縮性側索硬化症 / VCP / p97 / アンドロゲン受容体 / CAGリピート / トランスジェニックマウス / 酵母Two-Hybrid / マススペクトロメトリー … More / 蛋白分解 / DNA chip / 遺伝子発現解析 / LHRHアナログ / HSP70 / spinal and bulbar muscular atrophy / 微小管結合蛋白 / MAP1B / パーキンソン病 / アルツハイマー病 / Hsp90阻害剤 / Hsp70 / GGA / 分子インデックス法 / 遺伝子発現プロファイル / 運動ニューロン死 / 新規遺伝子 / リングフィンガーモチーフ / ユビキチン系 / 運動ニューロン疾患 / 神経悪性疾患 / Amyotrophic Lateral Screlosis / Molecular Indexing / Expressed-Gene Profile / Motor Neuron Death / Novel Genes / Ring Finger / IBR Motif / Ubiquitination / CAGリピート病 / ポリグルタミン鎖 / 神経細胞死 / アデノウイルスベクター / 培養神経系細胞モデル / ポリグルタミン凝集体 / CAG repeat disease / polyglutamine tract / neuronal cell death / Spinal and bulbar muscular atrophy / adenovirus vector / In vitro neuronal cell culture model / Gene expression analysis / 去勢術 / テストステロン / ホルモン治療 / Hsp / androgen receptor / CAG repeat / transgenic mouse / castration / LHRH analogue / protein degradation / 運動ニューロン / ポリグルタミン / 臨床試験 / バイオマーカー / 分子シャペロン / ヒストン脱アセチル化 / ユビキチンリガーゼ / motor neuron / amyotrophic lateral sclerosis / polyglutamine / LHRH analog / gene expression profiles / 疾患iPS細胞 / 骨格筋 … More Except Principal Investigator ポリグルタミン / 運動ニューロン / 球脊髄性筋萎縮症 / アンドロゲン受容体 / ALS / HSP / 17-AAG / GGA / dynactin1 / 遺伝子発現解析 / geranylgeranylaceone / motor neuron / heat shock protein / レーザーマイクロダイセクション法 / cDNAマイクロアレー / 球脊髄性筋萎縮症(SBMA) / 軸索輸送 / ユビキチン-プロテアソーム / 分子シャペロン / CAGリピート / 神経変性 / LHRHアナログ / ヒストン / 熱ショックタンパク質 / テストステロン / polyglutamine / histone / chemokine / chemokine receptor / Th1 / Th2 / MCP-1 / MIP-1β / RANTES / IP-10 / siRNA / 筋萎縮性側索硬化症 / パーキンソン病 / 分子インデックス法 / 病態関連遺伝子 / 遺伝子発現 / クローニング / 運動ニューロン疾患 / 筋萎縮性側索硬化症(ALS) / 発現遺伝子プロファイル / 脊髄小脳失調症(SCA) / 転写障害 / TGF-β / ユビキチン / プロテアソーム / 17-DMAG / ポリグルタミン病 / CHIP / モーター蛋白質 / dnactin1 / ニューロフィラメント / 神経分子病態学 / ユビキチンープロテアソーム / リュープロレリン / ユビキチン・プロテアソーム / 熱ショック蛋白質 / cyclin C / 線虫 / 疾患モデル / dynactinl / アロドロゲン受容体 / トランスジェニックマウス / 去勢術 / HSP70 / びまん性核内蓄積 / ホルモン治療 / Hsp / CAGリピート病 / ポリグルタミン鎖 / 神経細胞死 / アデノウイルスベクター / 培養神経系細胞モデル / DNA chip / アンドロゲン受容体(AR) / neurodegeneration / andorogen receptor / LHRH analog / 炎症性筋疾患 / 多発筋炎 / 皮膚筋炎 / 封入体筋炎 / Inflammatory myopathy / フルタミド / Neurodegeneration / androgen receptor / バイオマーカー / 神経変性疾患 / spinal and bulbar muscular atrophy / molecular chaperone / ubiquitin-proteasome / biomarker / オートファジー / cDNAマイクロアレイ / gene expression analysis / autophagy / 甲状腺眼症 / 平滑筋線維 / 筋線維芽細胞 / 脱分化 / 平滑筋細胞 / 外眼筋周囲脂肪組織 / 線維芽細胞 / 神経病理解析 / 疾患レジストリ / missing heritability / 構造多型 / リピート伸長変異 Less

Elucidating the heterogeneity of amyotrophic lateral sclerosis by neuropathological analysis linked to clinical genomic information
- Principal Investigator
  
  熱田直樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Aichi Medical University
筋萎縮性側索硬化症のmissing heritabilityに関わる遺伝子の探索
- Principal Investigator
  
  中村亮一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Aichi Medical University
Elucidaion of muscular pathology of SBMA using disease specific iPSCsPrincipal Investigator
- Principal Investigator
  
  道勇学
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Aichi Medical University
甲状腺眼症における筋線維芽細胞の起源の研究
- Principal Investigator
  
  柿崎裕彦
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Aichi Medical University
Pathogenesis-based therapy development for polyglutamine diseases
- Principal Investigator
  
  SOBUE Gen
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Development of animal model for sporadic ALS
- Principal Investigator
  
  TANAKA Fumiaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Development of pathogenesis-based therapy for polyglutamine diseases
- Principal Investigator
  
  SOBUE Gen
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
分子シャペロンによる運動ニューロン疾患治療法の開発-SBMA・ALSを中心に-Principal Investigator
- Principal Investigator
  
  道勇学
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Treatment of polyglutamine disease using small molecular compound
- Principal Investigator
  
  SOBUE Gen
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Exploration of Target Molecules Related to Pathogenesis and Development of Therapy for Sporadic ALS
- Principal Investigator
  
  TANAKA Fumiaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
ユビキチンリガーゼDorfinの基質タンパク質の探索-神経変性との関連Principal Investigator
- Principal Investigator
  
  道勇学
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Development of low-molecular-weight compound therapy for polyglutamine diseasesPrincipal Investigator
- Principal Investigator
  
  DOYU Manabu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
孤発性ALSにおけるユビキチンリガーゼDorfinの基質タンパク質の探索Principal Investigator
- Principal Investigator
  
  道勇学
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Development of Pathogenesis-based treatment for spinal and bulbar muscular atrophy
- Principal Investigator
  
  SOBUE Gen
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Investigation into pathology of CAG repeat diseases and development of therapiesPrincipal Investigator
- Principal Investigator
  
  DOYU Manabu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
investigation of pathomechanism of inflammatory myopathy (in view of chemokines)
- Principal Investigator
  
  INUKAI Akira
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  NAGOYA UNIVERSITY
運動ニューロン疾患の神経細胞死に係わる分子群の同定
- Principal Investigator
  
  祖父江元
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagoya University
Elucidation of molecular mechanism of neuronal cell death in spinal and bulbar muscular atrophy
- Principal Investigator
  
  SOBUE Gen
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Elucidation of pathogenesis in CAG-repeat diseases using DNA chipPrincipal Investigator
- Principal Investigator
  
  DOYU Manabu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
遺伝子発現プロファイリングによるパーキンソン病の病態関連遺伝子の同定
- Principal Investigator
  
  SOBUE Gen
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagoya University
Detection of Relating Molecules for the Pathology of Amyotrophic Lateral Screlosis by the Expressed-Gene ProfilingPrincipal Investigator
- Principal Investigator
  
  DOYU Manabu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University

All 2021 2020 2019 2010 2009 2007 2006 2005 2004 2003 2001

All Journal Article Presentation

[Journal Article] Modulation of oxygen tension, acidosis, and cell density is crucial for neural differentiation of human induced pluripotent stem cells2021
- Author(s)
  Okada R, Onodera K, Ito T, Doyu M, Okano HJ, Okada Y
- Journal Title
  
  Neurosci Res.
  
  Volume: - Pages: 30043-2
- DOI
  10.1016/j.neures.2020.01.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-18K15470, KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-20K16611, KAKENHI-PROJECT-19H03576, KAKENHI-PROJECT-19J40240
[Journal Article] 疾患特異的iPS細胞を用いた神経変性疾患の病態解析と新規治療法開発2020
- Author(s)
  Onodera K, Shimojo D, Ishihara Y, Yano M, Miya F, Banno H, Kuzumaki N, Ito T, Okada R, Ohyama M, Yoshida M, Tsunoda T, Katsuno M, Doyu M, Sobue G, Okano H, Okada Y
- Journal Title
  
  Molecular Brain
  
  Volume: 13 Pages: 1315-1319
- DOI
  10.1186/s13041-020-0561-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-17H04195, KAKENHI-PROJECT-19H03576, KAKENHI-PROJECT-18K15470, KAKENHI-PROJECT-20K16587, KAKENHI-PROJECT-20K16611, KAKENHI-PROJECT-19J40240
[Journal Article] Motor Improvement-Related Regional Cerebral Blood Flow Changes in Parkinson's Disease in Response to Antiparkinsonian Drugs.2019
- Author(s)
  Taguchi S, Tanabe N, Niwa JI, Doyu M.
- Journal Title
  
  Parkinsons Dis.
  
  Volume: 0 Pages: 7503230-7503230
- Data Source
  KAKENHI-PROJECT-19K07969
[Journal Article] Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis.2010
- Author(s)
  Sone J, Niwa JI, Kawai K, Ishigaki S, Yamada SI, Adachi H, Katsuno M, Tanaka F, Doyu M, Sobue G.
- Journal Title
  
  J Neurosci Res. 88
  
  Pages: 123-135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy2009
- Author(s)
  Banno, H., Katsuno, M., Suzuki, K., Takeuchi, Y., Kawashima, M., Suga, N., Takamori, M., Ito, M., Nakamura, T., Matsuo, K., Yamada, S., Oki, Y., Adachi, H., Minamiyama, M., Waza, M., Atsuta, N., Watanabe, H., Fujimoto, Y., Nakashima, T., Tanaka, F., Doyu, M., Sobue, G.
- Journal Title
  
  Ann Neurol 65
  
  Pages: 140-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy2009
- Author(s)
  Banno H, Katsuno M, Suzuki K, Takeuchi Y, Kawashima M, Suga N, Takamori M, Ito M, Nakamura T, Matsuo K, Yamada S, Oki Y, Adachi H, Minamiyama M, Waza M, Atsuta N, Watanabe H, Fujimoto Y, Nakashima T, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Ann. Neurol 65
  
  Pages: 140-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy2009
- Author(s)
  Banno H, Katsuno M, Suzuki K, Takeuchi Y, Kawashima M, Suga N, Takamori M, Ito M, Nakamura T, Matsuo K, Yamada S, Oki Y, Adachi H, Minamiyama M, Waza M, Atsuta N, Watanabe H, Fujimoto Y, Nakashima T, Tanaka F, Doyu M, Sobue G.
- Journal Title
  
  Ann Neurol. 65
  
  Pages: 140-150
- Data Source
  KAKENHI-PROJECT-19390238
[Journal Article] Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity2007
- Author(s)
  Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, Sobue G.
- Journal Title
  
  Neurobiol Dis 25
  
  Pages: 331-341
- Data Source
  KAKENHI-PROJECT-19390238
[Journal Article] Nonmyelinating Schwann cell involvement with well-preserved unmyelinated axons in Charco-Matie-Tooth disease type 1A2007
- Author(s)
  Koike H, Iijima M, Mori K, Yamamoto M, Hattori N, Katsuno M, Tanaka F, Watanabe H, Doyu M, Yoshikawa H, Sobue G
- Journal Title
  
  J Neuropathol Exp Neurol 66
  
  Pages: 1027-1036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model2007
- Author(s)
  Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G.
- Journal Title
  
  J Neurosci 27
  
  Pages: 5115-5126
- Data Source
  KAKENHI-PROJECT-19390238
[Journal Article] CHIP Overexpression Reduces Mutant Androgen Receptor Protein and Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model2007
- Author(s)
  Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J. Neurosci 27
  
  Pages: 5115-5126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy2007
- Author(s)
  Adachi H, Waza M, Katsuno M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Neuropathol Appl Neurobiol 33
  
  Pages: 135-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy2007
- Author(s)
  Adachi H, Waza M, Katsuno M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Neuropathol Appl Neurobiol 33
  
  Pages: 135-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity.2007
- Author(s)
  Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, Sobue G
- Journal Title
  
  Neurobiol of Dis 25
  
  Pages: 331-341
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD12007
- Author(s)
  Niwa J, Yamada S, Ishigaki S, Sone J, Takahashi M, Katsuno M, Tanaka F, Doyu M, Sobue G.
- Journal Title
  
  J Biol Chem 282
  
  Pages: 28087-28095
- Data Source
  KAKENHI-PROJECT-19390238
[Journal Article] Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD12007
- Author(s)
  Niwa J, Yamada S, Ishigaki S, Sone J, Takahashi M, Katsuno M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Biol Chem 282
  
  Pages: 28087-28095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Reduces Mutant Androgen Receptor protein and Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model2007
- Author(s)
  Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanak F, Doyu M, Sobue G
- Journal Title
  
  J Neurosci 27
  
  Pages: 5115-5126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Gene expressions specifically detected in motor neurons (dynactin 1, early growth response 3, Acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to athologic markers in sporadic amyotrophic lateral sclerosis2007
- Author(s)
  Jiang Y, Yamamoto M, Tanaka F, Ishigaki S, Katsuno M, Adachi H, Niwia J, Doyu M, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Neuropathol Exp Neurol 66
  
  Pages: 617-627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD12007
- Author(s)
  Niwa J, Yamada S, Ishigaki S, Sone J, Takahashi M, Katsuno M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Biol Chem 282
  
  Pages: 28087-28095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Gene expressions specifically detected in motor neurons (dynactin l, early growth response 3, Acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to athologic markers in sporadic amyotrophic lateral sclerosis2007
- Author(s)
  Jiang Y, Yamamoto M, Tanaka F, Ishigaki S, Katsuno M, Adachi H, Niwia J, Doyu M, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Neuropathol Exp Neurol 66
  
  Pages: 617-627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy2007
- Author(s)
  Adachi H, Waza M, Katsuno M, Tanaka F, Doyu M, Sobue G.
- Journal Title
  
  Neuropathol Appl Neurobiol 33
  
  Pages: 135-151
- Data Source
  KAKENHI-PROJECT-19390238
[Journal Article] Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity2007
- Author(s)
  Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, Sobue G
- Journal Title
  
  Neurobiol of Dis 25
  
  Pages: 331-341
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SODI proteins and reduce their cellular toxicity2007
- Author(s)
  Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, Sobue G
- Journal Title
  
  Neurobiol Dis 25
  
  Pages: 331-241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity2007
- Author(s)
  Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, Sobue G
- Journal Title
  
  Neurobiol of Dis 25
  
  Pages: 331-341
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Nonmyelinating Schwann cell involvement with well-preserved unmyelinated axons in Charco-Matie-Tooth disease type 1A2007
- Author(s)
  Koike H, Iijima M, Mori K, Yamamoto M, Hattori N, Katsuno M, Tanaka F, Watanabe H, Doyu M, Yoshikawa H, Sobue G
- Journal Title
  
  J Neuropathol Exp Neurol 66
  
  Pages: 1027-1036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SODI proteins and reduce their cellular toxicity2007
- Author(s)
  Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, Sobue G
- Journal Title
  
  Neurobiol Dis 25
  
  Pages: 331-241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model2007
- Author(s)
  Adachi, H., Waza, M., Tokui, K., Katsuno, M., Minamiyama, M., Tanaka, F., Doyu, M., Sobue, G.
- Journal Title
  
  J. Neurosci 27
  
  Pages: 5115-5126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy2007
- Author(s)
  Adachi H, Waza M, Katsuno M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Neuropathol. Appl. Neurobiol 33
  
  Pages: 135-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Reduces Mutant Androgen Receptor Protein and Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model2007
- Author(s)
  Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanak F, Doyu M, Sobue G
- Journal Title
  
  J Neurosci 27
  
  Pages: 5115-5126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Gene expressions specifically detected in motor neurons (dynactin 1, early growth response 3, acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to pathologic markers in sporadic amyotrophic lateral sclerosis2007
- Author(s)
  Jiang YM, Yamamoto M, Tanaka F, Ishigaki S, Katsuno M, Adachi H, Niwa J, Doyu M, Yoshida M, Hashizume Y, Sobue G.
- Journal Title
  
  J Neuropathol Exp Neurol 66
  
  Pages: 617-627
- Data Source
  KAKENHI-PROJECT-19390238
[Journal Article] Pathogenesis, animal models and therapeutics in spinal and bulbar muscular atrophy (SBMA).2006
- Author(s)
  Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Exp Neurol in press
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Modulation of Hsp90 function in neurodegenerative disorders : amolecular-targeted therapy against disease-causing protein2006
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Mol Med 84
  
  Pages: 635-646
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Modulation of Hsp90 function in neurodegenerative disorders : a molecular targeted therapy against disease-causing protein.2006
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Mol Med (in press)
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Gene expression profiling toward understanding of ALS pathogenesis2006
- Author(s)
  Tanaka F, Niwa J, Ishigaki S, Katsuno M, Waza M, Yamamoto M, Doyu M, Sobue G
- Journal Title
  
  Ann N Y Acad Sci 1086
  
  Pages: 1-10
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Modulation of Hsp90 function in neurodegenerative disorders : a molecular-targeted therapy against disease-causing protein2006
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Mol Med 84
  
  Pages: 635-646
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Pathogenesis, animal models and therapeutics in Spinal and bulbar muscular atrophy (SBMA).2006
- Author(s)
  Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Exp Neurol 200
  
  Pages: 8-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Gene expression profiling toward understanding of ALS pathogenesis2006
- Author(s)
  Tanaka F, Niwa J, Ishigaki S, Katsuno M, Waza M, Yamamoto M, Doyu M, Sobue G
- Journal Title
  
  Ann N Y Acad Sci 1086
  
  Pages: 1-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Pathogenesis, animal models and therapeutics in spinal and bulbar muscular atrophy (SBMA).2006
- Author(s)
  Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Exp Neurol (in press)
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Modulation of Hsp90 function in neurodegenerative disorders : a molecular-targeted therapy against disease-causing protein.2006
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Mol Med 84
  
  Pages: 635-646
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Modulation of Hsp90 function in neurodegenerative disorders : a molecular-targeted therapy against disease-causing protein2006
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Mol Med 84
  
  Pages: 635-646
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Pathogenesis, animal models and therapeutics in spinal and bulbar muscular atrophy (SBMA).2006
- Author(s)
  Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Exp Neurol (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration2006
- Author(s)
  Katsuno M, Adachi H, Minamiyama M, Waza M, Tokui K, Banno H, Suzuki K, Onoda Y, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Neurosci 26
  
  Pages: 12106-12117
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells.2006
- Author(s)
  Yamada S, Niwa J, Ishigaki S, Takahashi M, Ito T, Sone J, Doyu M, Sobue G
- Journal Title
  
  J Biol Chem 281
  
  Pages: 23842-23851
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin : A pathogenic marker2006
- Author(s)
  Banno H, Adachi H, Katsuno M, Suzuki K, Atsuta N, Watanabe H, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Ann Neurol 59
  
  Pages: 520-526
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin : A pathogenic marker.2006
- Author(s)
  Banno H, Adachi H, Katsuno M, Suzuki K, Atsuta N, Watanabe H, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Ann Neurol 59
  
  Pages: 520-526
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Pathogenesis, animal models and therapeutics in spinal and bulbar muscular atrophy (SBMA).2006
- Author(s)
  Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Exp Neurol (in press)
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Modulation of Hsp90 function in neurodegenerative disorders : a molecular targeted therapy against disease-causing protein.2006
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Mol Med (in press)
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin : A pathogenic marker.2006
- Author(s)
  Banno H, Adachi H, Katsuno M, Suzuki K, Atsuta N, Watanabe H, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Ann Neurol 59
  
  Pages: 520-526
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Pathogenesis, animal models and therapeutics in Spinal and bulbar muscular atrophy (SBMA)2006
- Author(s)
  Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Exp Neurol 200
  
  Pages: 8-18
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration2006
- Author(s)
  Katsuno M, Adachi H, Minamiyama M, Waza M, Tokui K, Banno H, Suzuki K, Onoda Y, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Neurosci 26
  
  Pages: 12106-12117
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Gene expression profiling toward understanding of ALS pathogenesis2006
- Author(s)
  Tanaka F, Niwa J, Ishigaki S, Katsuno M, Waza M, Yamamoto M, Doyu M, Sobue G
- Journal Title
  
  Ann NY Acad Sci 1086
  
  Pages: 1-10
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells2006
- Author(s)
  Yamada S, Niwa J, Ishigaki S, Takahashi M, Ito T, Sone J, Doyu M, Sobue G
- Journal Title
  
  J Biol Chem 281
  
  Pages: 23842-23851
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin : A pathogenic marker.2006
- Author(s)
  Banno H, Adachi H, Katsuno M, Suzuki K, Atsuta N, Watanabe H, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Ann Neurol 59
  
  Pages: 520-526
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Gene expression profiling toward understanding of ALS pathogenesis.2006
- Author(s)
  Tanaka F, Niwa J, Ishigaki S, Katsuno M, Waza M, Yamamoto M, Doyu M, Sobue G
- Journal Title
  
  Ann NY Acad Sci 1086
  
  Pages: 1-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration.2006
- Author(s)
  Katsuno M, Adachi H, Minamiyama M, Waza M, Tokui K, Banno H, Suzuki K, Onoda Y, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Neurosci 26
  
  Pages: 12106-12117
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Pathogenesis, animal models and therapeutics in Spinal and bulbar muscular atrophy (SBMA)2006
- Author(s)
  Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Exp Neurol 200
  
  Pages: 8-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells2006
- Author(s)
  Yamada S, Niwa J, Ishigaki S, Takahashi M, Ito T, Sone J, Doyu M, Sobue G
- Journal Title
  
  J Biol Chem 281
  
  Pages: 23842-23851
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin : A pathogenic marker2006
- Author(s)
  Banno H, Adachi H, Katsuno M, Suzuki K, Atsuta N, Watanabe H, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Ann Neurol 59
  
  Pages: 520-526
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients.2005
- Author(s)
  Adachi H, Katsuno M, Minamiyama M, Sang C, Nakagomi Y, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Brain 128
  
  Pages: 659-670
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease.2005
- Author(s)
  Katsuno M, Sang C, Adachi H, Minamiyama M, Waza M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Proc Natl Acad Sci USA 102
  
  Pages: 16801-16806
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Widespread nuclear and cytoplasmic mutant androgen receptor accumulation in spinal and bulbar muscular atrophy.2005
- Author(s)
  Adachi H, Katsuno M, Minamiyama M, Waza M, Sang C, Nakagomi Y, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Brain 128
  
  Pages: 659-670
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration.2005
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Sang C, Tanaka F, Inukai A, Doyu M, Sobue G
- Journal Title
  
  Nature Med 11
  
  Pages: 1088-1095
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease.2005
- Author(s)
  Katsuno M, Sang C, Adachi H, Minamiyama M, Waza M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Proc Natl Acad Sci Usa 102
  
  Pages: 16801-16806
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Gene expression profile of motor neurons in sporadic amyotrophic lateral sclerosis.2005
- Author(s)
  Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S, Takeuchi H, Ishigaki S, Katsuno M, Adachi H, Niwa J, Tanaka F, Doyu M, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Ann Neurol 57
  
  Pages: 236-251
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Widespread nuclear and cytoplasmic mutant androgen receptor accumulation in spinal and bulbar muscular atrophy.2005
- Author(s)
  Adachi H, Katsuno M, Minamiyama M, Waza M, Sang C, Nakagomi Y, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Brain 128
  
  Pages: 659-670
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease.2005
- Author(s)
  Katsuno M, Sang C, Adachi H, Minamiyama M, Waza M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Proc Natl Acad Sci USA 102
  
  Pages: 16801-16806
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Widespread nuclear and cytoplasmic mutant androgen receptor accum ulation in spinal and bulbar muscular atrophy.2005
- Author(s)
  Adachi H, Katsuno M, Minamiyama M, Waza M, Sang C, Nakagomi Y, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Brain 128
  
  Pages: 659-670
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Gene expression profile of motor neurons in sporadic amyotrophic lateral sclerosis.2005
- Author(s)
  Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S, Takeuchi H, Ishigaki S, Katsuno M, Adachi H, Niwa J, Tanaka F, Doyu M, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Ann Neurol 57
  
  Pages: 236-251
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration2005
- Author(s)
  Waza, M., Adachi, H., Katsuno, M., Minamiyama, M., Sang, C., Tanaka, F., Inukai, A., Doyu, M., Sobue, G.
- Journal Title
  
  Nat. Med. 11
  
  Pages: 1088-1095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration.2005
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Sang C, Tanaka F, Inukai A, Doyu M, Sobue G
- Journal Title
  
  Nature Med 11
  
  Pages: 1088-1095
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease2005
- Author(s)
  Katsuno, M., Sang, C., Adachi, H., Minamiyama, M., Waza, M., Tanaka, F., Doyu, M., Sobue, G.
- Journal Title
  
  Proc. Natl. Acad. Sci. U.S.A. 102
  
  Pages: 16801-16806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease.2005
- Author(s)
  Katsuno M, Sang C, Adachi H, Minamiyama M, Waza M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Proc Natl Acad Sci USA 102
  
  Pages: 16801-16806
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration.2005
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Sang C, Tanaka F, Inukai A, Doyu M, Sobue G
- Journal Title
  
  Nature Med 11
  
  Pages: 1088-1095
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Gene expression profile of motor neurons in sporadic amyotrophic lateral sclerosis.2005
- Author(s)
  Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S, Takeuchi H, Ishigaki S, Katsuno M, Adachi H, Niwa J, Tanaka F, Doyu M, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Ann Neurol 57
  
  Pages: 236-251
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Gene expression profile of motor neurons in sporadic amyotrophic lateral sclerosis.2005
- Author(s)
  Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S, Takeuchi H, Ishigaki S, Katsuno M, Adachi H, Niwa J, Tanaka F, Doyu M, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Ann Neurol 57
  
  Pages: 236-251
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis.2004
- Author(s)
  Takeuchi H, Niwa J, Hishikawa N, Ishigaki S, Tanaka F, Doyu M, Sobue G.
- Journal Title
  
  J Neurochem. 89
  
  Pages: 64-72
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy.2004
- Author(s)
  Minamiyama M, Katsuno M, Adachi H, Waza M, Sang C, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Sobue G.
- Journal Title
  
  Hum Mol Genet 13
  
  Pages: 1183-1192
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Dorfin prevents cell death by reducing mitochondrial localising mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis.2004
- Author(s)
  Takeuchi H, Niwa J, Hishikawa N, Ishigaki S, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Neurochem 89
  
  Pages: 64-72
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy.2004
- Author(s)
  Minamiyama M, Katsuno M, Adachi H, Waza M, Sang C, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Sobue G
- Journal Title
  
  Hum Mol Genet 13
  
  Pages: 1183-1192
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy.2004
- Author(s)
  Minamiyama M, Katsuno M, Adachi H, Waza M, Sang C, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Sobue G
- Journal Title
  
  Hum Mol Genet 13
  
  Pages: 1183-1192
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Dorfin localizes to the ubiquitilated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis.2003
- Author(s)
  Hishikawa N, Niwa J, Doyu M, Ito T, Ishigaki S, Hashizume Y, Sobue G
- Journal Title
  
  Am J Pathol 163(2)
  
  Pages: 609-619
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Caspase-1 and -3 are differentially upregulated in motor neurons and glial cells in mutant SOD1 transgenic mouse spinal cord : a study usign laser microdissection and real time RT-PCR.2003
- Author(s)
  Ando Y, Liang Y, Ishigaki S, Niwa J, Jiang Y, Kobayashi Y, Yamamoto M, Doyu M, Sobue G
- Journal Title
  
  Neurochem Res 28
  
  Pages: 839-846
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1.2003
- Author(s)
  Ito T, Niwa J, Hishikawa N, Ishigaki S, Doyu M, Sobue G
- Journal Title
  
  J Biol Chem 278(31)
  
  Pages: 29106-29114
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Leuprorelin rescue polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy.2003
- Author(s)
  Katsuno M, Adachi H, Doyu M, Minamiyama M, Sang C, Kobayashi Y, Inukai A, Sobue G
- Journal Title
  
  Nature Medicine 9(6)
  
  Pages: 768-773
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein.2003
- Author(s)
  Adachi H, Katsuno M, Minamiyama M, Sang C, Pagoulatous G, Angelidis C, Kusakabe M, Yoshiki A, Kobayashi Y, Doyu M, Sobue G
- Journal Title
  
  J Neurosci 23(6)
  
  Pages: 2203-2211
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Gene expression profile in Alzheimer's brain screened by molecular indexing.2001
- Author(s)
  Doyu M
- Journal Title
  
  Brain Res, Mol Brain Res 87
  
  Pages: 1-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210010
[Journal Article] Gene expression profile in Alzheimer's brain screened by molecular indexing.2001
- Author(s)
  Doyu M
- Journal Title
  
  Mol Brain Res 87
  
  Pages: 1-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210010
[Presentation] 疾患iPS細胞による神経・筋共培養を活用した神経変性疾患の病態解析2020
- Author(s)
  伊藤卓治, 小野寺一成, 小野寺一成, 下門大祐, 下門大祐, 田中智史, 田中智史, 岡田梨奈, RASHID Muhammad Irfanur, 道勇学, 岡野栄之, 岡田洋平
- Organizer
  日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Reconstruction of motor function in peripheral nerves by transplanatation of human iPSC-derived motor neuron progenitors.2019
- Author(s)
  Niwa S, Saeki M, Shinkai H, Kurimoto S, Hirata H, Doyu M, Okada Y
- Organizer
  ISSCR 2019 Annual Meeting, LosAngeles
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Pathophysiological analysis of spinal and bulbar muscular atrophy using disease-specific iPSCs.2019
- Author(s)
  Onodera K， Shimojo D， Yoda M, Ishihara Y， Ito T, Okada R, Doyu M， Katsuno M， Okano H， Sobue G， Okada Y
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Elucidation of non-cell autonomous neurodegeneration in spinal and bulbar muscular atrophy using iPSC-derived neuromuscular models.2019
- Author(s)
  Ito T, Tanaka S, Shimojo D, Doyu M, Okano H, Okada Y
- Organizer
  ISSCR 2019 Annual Meeting, LosAngeles
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] The effects of hypoxia on differentiation and maturation of human induced pluripotent stem cell-derived neural progenitors.2019
- Author(s)
  Okada Y, Okada R, Li J, Onodera K, Ito T, Okano HJ, Doyu M
- Organizer
  ISSCR 2019 Annual Meeting, LosAngeles
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy2009
- Author(s)
  Banno, H., Katsuno, M., Suzuki, K., Takeuchi, Y., Kawashima, M., Suga, N., Takamori, M., Ito, M., Nakamura, T., Matsuo, K., Yamada, S., Oki, Y., Adachi, H., Minamiyama, M., Waza, M., Atsuta, N., Watanabe, H., Fujimoto, Y., Nakashima, T., Tanaka, F., Doyu, M., Sobue, G.
- Organizer
  61th American Academy of Neurology Annual Meeting
- Place of Presentation
  Seattle, USA
- Data Source
  KAKENHI-PROJECT-17025020
[Presentation] Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy.2009
- Author(s)
  Banno H, Katsuno M, Suzuki K, Takeuchi Y, Kawashima M, Suga N, Takamori M, Ito M, Nakamura T, Matsuo K, Yamada S, Oki Y, Adachi H, Minamiyama M, Waza M, Atsuta N, Watanabe H, Fujimoto Y, Nakashima T, Tanaka F, Doyu M, Sobue G.
- Organizer
  61th American Academy of Neurology Annual Meeting
- Place of Presentation
  Seattle, USA
- Year and Date
  2009-04-26
- Data Source
  KAKENHI-PROJECT-17025020
[Presentation] 孤発性ALS疾患モデルの開発 : dynactin1ノックダウン細胞の解析2007
- Author(s)
  田中章景、黄哲、蒋月梅、松尾幸治、和座雅浩、山本正彦、道勇学、祖父江元
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-16
- Data Source
  KAKENHI-PROJECT-19390238
[Presentation] Gen expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis2006
- Author(s)
  Tanaka, F., Jiang, Y.M., Yamamoto, M., Huang, Z., Katsuno, M., Adachi, H., Niwa, J.I., Doyu, M., Sobue, G.
- Organizer
  17th International Symposium on ALS/MND
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-17025020

1. SOBUE Gen (20148315)

# of Collaborated Projects: 16 results

# of Collaborated Products: 86 results
2. TANAKA Fumiaki (30378012)

# of Collaborated Projects: 8 results

# of Collaborated Products: 66 results
3. INUKAI Akira (30314016)

# of Collaborated Projects: 6 results

# of Collaborated Products: 3 results
4. KATSUNO Masahisa (50402566)

# of Collaborated Projects: 3 results

# of Collaborated Products: 39 results
5. ADACHI Hiroaki (40432257)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
6. 熱田直樹 (90547457)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 中村亮一 (80723030)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 藤内玄規 (00748353)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. IIJIMA Masahiro (40437041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMAMOTO Masahiko (40378039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 服部直樹 (10402570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 柿崎裕彦 (20329783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中野隆 (30148332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 高橋靖弘 (70557206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 岡田洋平 (30383714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
16. 伊藤卓治 (30794151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 陸雄一 (50748382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 若井正一

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

DOYU Manabu 道勇 学

道勇 学 ドウユウ マナブ

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Elucidaion of muscular pathology of SBMA using disease specific iPSCsPrincipal Investigator

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分子シャペロンによる運動ニューロン疾患治療法の開発-SBMA・ALSを中心に-Principal Investigator

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ユビキチンリガーゼDorfinの基質タンパク質の探索-神経変性との関連Principal Investigator

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Development of low-molecular-weight compound therapy for polyglutamine diseasesPrincipal Investigator

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孤発性ALSにおけるユビキチンリガーゼDorfinの基質タンパク質の探索Principal Investigator

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DOYU Manabu 道勇学

道勇学ドウユウマナブ