SEKI Narihito 関成人

… Alternative Names

関成人セキナリヒト

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Researcher Number	90294941
Affiliation (Current)	2025: 公立学校共済組合九州中央病院(臨床研究センター), 臨床研究センター, 研究員
Affiliation (based on the past Project Information) *help	2013: 九州大学, 医学(系)研究科(研究院), 研究員 2013: 九州大学, 大学院医学研究院, 准教授 2012: 九州大学, 医学(系)研究科(研究院), 共同研究員 2012: 九州大学, 医学研究院, 特別研究員 2011: 九州大学, 医学(系)研究科(研究院), 特別研究員 … More 2011: 九州大学, 医学研究院, 共同研究員 2010: 九州大学, 大学院・医学研究院, 准教授 2007 – 2010: Kyushu University, 医学研究院, 准教授 2008: Kyushu University, 大学院医学研究院, 准教授 2005: Kyushu University Hospital, Assistant Professor, 九州大学病院, 講師 2003 – 2005: Kyushu University, Kyushu University Medical Hospital, Assistant Professor, 大学病院, 講師 2002 – 2003: 九州大学, 大学院・医学研究院, 講師 2002: Department of Urology, Assistant professor, 医学部附属病院, 講師 2000 – 2001: 九州大学, 大学院・医学研究院, 助手 Less
Review Section/Research Field	Principal Investigator Urology / Urology Except Principal Investigator Urology / General pharmacology / General pharmacology
Keywords	Principal Investigator Rho kinase / 過活動膀胱 / Protein kinase C / ATP / ヒト排尿筋 / カルシウム感受性 / カルバコール / 膀胱出口閉塞 / 排尿筋 / Human prostate … More / Carbachol / Ca sensitization / Human detrusor smooth muscle / Intracellular Ca concentration / ヒト前立腺 / 細胞内カルシウム / Patch clamp / Acetylcholine / neuro-muscular transmission / Potassium channel / Purinergic receptor / human detrusor / 脱分極 / 細胞内微小電極法 / ヒト膀胱排尿筋 / スルフォニルウレア受容体 / パッチクランプ法 / アセチルコリン / 神経-筋伝達 / カリウムチャネル / プリン受容体 / ギャップジャンクン / 間質性細胞 / 神経伝達物質 / 膀胱排尿筋 / カルシウム電流 / 間質細胞 / ムスカリン受容体 / αトキシン / 下部尿路機能障害 / RhoA-kinase / スキンド標本 / 細胞内Ca^<2+>濃度 / モルモット / Ca^<2+>感受性調節機序 … More Except Principal Investigator イオンチャネル / 平滑筋 / 膀胱排尿筋 / Receptor / Vascular smooth muscle / Ion channels / ATP / 国際研究者交流 / ATP感受性カリウムチャネル / ヒト血管平滑筋細胞 / 受容体 / 血管平滑筋 / アデノシン三リン酸 / K^+ channel openers / Drugs for urinary incontinence / Drugs for freauent micturition / ATP-sensitive K^+ channels / Unstable bladder / Human detrusor smooth muscle / 治療薬 / 電気生理学 / カリウムチャネル / K^+チャネル開口薬 / 尿失禁治療薬 / 頻尿治療薬 / ATP感受性K^+チャネル / 不安定膀胱 / ヒト膀胱平滑筋 / トロポニンT / 膀胱平滑筋 / 筋収縮機構 / 排尿筋 / 低活動膀胱 / 排尿機能 / トロポニン / 特殊間質性細 / カルシウムオシレーション / 特殊間質性細胞 / 過活動膀胱 Less

The basic research for the novel treatment for under active bladder -focusing on the construction of troponin system in smooth muscle-
- Principal Investigator
  
  KAJIOKA Shunichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kyushu University
The morphological and physiological investigation into the interstitial cells of human and guinea-pig urinary bladder.Principal Investigator
- Principal Investigator
  
  SEKI Narihito
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kyushu University
The investigation into the molecular and electrophysiological properties of overactive bladder and the research for the novel consequent treatment
- Principal Investigator
  
  KAJIOKA Shunichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kyushu University
The correlation between bladder outlet obstruction and calcium sensitization mechanism in human and guinea pig detrusor smooth musclePrincipal Investigator
- Principal Investigator
  
  SEKI Narihito
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kyushu University
Molecular and pharmacological studies of human vascular-type ATP-sensitive K+ channels regarding the channel kinetics
- Principal Investigator
  
  TERAMOTO Noriyoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  KYUSHU UNIVERSITY
Ca^<2+> sensitization of human and rabbit urinary bladder smooth musclePrincipal Investigator
- Principal Investigator
  
  SEKI Narihito
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  KYUSHU UNIVERSITY
Molecular and pharmacological investigation of ATP-sensitive K^+ channels in human detrusor
- Principal Investigator
  
  TERAMOTO Noriyoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
Passive membrane electrical property and neuro-muscular transmission in human detrusor smooth musclePrincipal Investigator
- Principal Investigator
  
  SEKI Narihito
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kyushu University

All 2012 2011 2010 2009 2008 2007 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] Functional role of muscarinic receptor subtypes in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle2012
- Author(s)
  Shahab N, Kajioka S, Seki N, Naito S
- Journal Title
  
  Urology
  
  Volume: 79(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591793
[Journal Article] TURP術後の最適なカテーテル抜去日2012
- Author(s)
  野尻佳克、荒井陽一、関成人、内藤誠二、町田二郎、長谷川友紀、服部良平、松田公志、矢内原仁、岡村菊夫
- Journal Title
  
  Jpn J Endourol
  
  Volume: 25 (1) Pages: 118-122
- NAID
  10031133485
- Data Source
  KAKENHI-PROJECT-22591793
[Journal Article] Endogenous cardiac troponin T modulates Ca^<2+> -mediated smooth muscle contraction2012
- Author(s)
  Kajioka S, Takahashi-Yanaga F, Shahab N,Onimaru M, Matsuda M, Takahashi R, Asano H, Morita H, Morimoto S, Yonemitsu Y, Hayashi M, Seki N, Sasaguri T, Hirata M, Nakayama S, Naito S
- Journal Title
  
  Sci Rep
  
  Volume: 2 Pages: 979-979
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591793
[Journal Article] Obstruction enhances rho-kinase pathway and diminishes protein kin-ase C pathway in carbachol-induced calcium sensitization in contraction of α-toxin permeabilized guinea pig detrusor smooth muscle2012
- Author(s)
  Shahab N, et.al.
- Journal Title
  
  Neurourol Urodyn
  
  Volume: (in Press) Issue: 4 Pages: 593-599
- DOI
  10.1002/nau.21193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590315, KAKENHI-PROJECT-22590347, KAKENHI-PROJECT-22591793, KAKENHI-PROJECT-23592371
[Journal Article] Japanese Society Of Endourology Laparoscopic Partial Nephrectomy Study Group: Surgical and oncologic outcomes of laparoscopic partial nephrectomy: a Japanese multi-institutional study of 1375 patients2012
- Author(s)
  Saito H, Matsuda T, Tanabe K, Kawauchi A, Terachi T, Nakagawa K, Iwamura M, Shigeta M,Tatsugami K, Ito A, Machida J, Kawakita M, Kinoshita H, Shinohara N, Ioritani N, Seki T, Arai Y
- Journal Title
  
  J Endourol
  
  Volume: 26 (6) Pages: 652-659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591793
[Journal Article] Obstruction enhances rho-kinase pathway and diminishes protein kinse C pathway in carbachol-induced calcium sensitization in α-toxin permeabilized Guinea pig detrusor smooth muscle2012
- Author(s)
  Shahab N, Kajioka S, Takahashi-Yanaga F,Onimaru M, Matsuda M, Seki N, Naito S
- Journal Title
  
  Neurourol & Urodynam
  
  Volume: 31(4) Pages: 593-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591793
[Journal Article] Endogenous cardiac troponin T modulates Ca(2+)-mediated smooth muscle contraction2012
- Author(s)
  Kajioka S, Takahashi-Yanaga F, Shahab N, Onimaru M, Matsuda M, Takahashi R, Asano H, Morita H, Morimoto S, Yonemitsu Y, Hayashi M, Seki N, Sasaguri T, Hirata M, Nakayama S, Naito S
- Journal Title
  
  Sci Rep
  
  Volume: 2 Pages: 979-979
- Data Source
  KAKENHI-PROJECT-23592371
[Journal Article] Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction ofα-toxin permeabilized guinea pig detrusor smooth muscle2012
- Author(s)
  Shahab N, Kajioka S, Takahashi-Yanaga F, Onimaru M, Matsuda M, Seki N, Naito S
- Journal Title
  
  Neurourol Urodyn
  
  Volume: 31(4) Pages: 593-599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592371
[Journal Article] Disphosphate regulation of adenosine triphosphate sensitive potassium channel in human bladder smooth muscle cells2011
- Author(s)
  Kajioka S, Shahab N, Asano H, Morita H, Sugihara M, Takahashi-Yanaga F, Yoshihara T, Nakayama S, Seki N, Naito S
- Journal Title
  
  Journal of Urology
  
  Volume: 186 Issue: 2 Pages: 736-744
- DOI
  10.1016/j.juro.2011.03.153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591793
[Journal Article] Naito S Diphosphate regulation of ATP-sensitive potassium channel in human urinary bladder smooth muscle cells.2011
- Author(s)
  Kajioka S, Shahab N, Asano H, Morita H, Sugihara M, Takahashi-Yanaga F, Yoshihara T, Nakayama S, Seki N, Brading F
- Journal Title
  
  J Urol in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599012
[Journal Article] Disphosphate regulation of adenosine triphosphate sensitive potassium channel in human bladder smooth muscle cells2011
- Author(s)
  Kajioka S, Shahab N, Asano H, Morita H,Sugihara M, Takahashi-Yanaga F, Yoshihara T, Nakayama S, Seki N, Naito S
- Journal Title
  
  J Urol
  
  Volume: 186 Pages: 736-744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591793
[Journal Article] 排尿障害治療薬2010
- Author(s)
  梶岡俊一, 関成人
- Journal Title
  
  新薬展望2010 46巻増刊号
  
  Pages: 369-373
- Data Source
  KAKENHI-PROJECT-20599012
[Journal Article] Etiology of overactive bladder and its therapeutic perspective--focusing on a myogenic basis for the overactive bladder2010
- Author(s)
  Kajioka S, Seki N, Shahab N, Yunoki T, Naito S.
- Journal Title
  
  Fukuoka Igaku Zasshi
  
  Volume: 101(5) Pages: 94-100
- Data Source
  KAKENHI-PROJECT-22591793
[Journal Article] Etiology of overactive bladder and its therapeutic perspective-focusing on a myogenic basis for the overactive bladder.2010
- Author(s)
  Kajioka S, Seki N, Shahab N, Yunoki T, Naito S.
- Journal Title
  
  Fukuoka Igaku Zasshi. 101(5)(review)
  
  Pages: 94-100
- Data Source
  KAKENHI-PROJECT-20599012
[Journal Article] Fifth joint meeting of the American Urological Association and the Japanese Urological Association International Affiliate Society Meeting at the 105th Annual Meeting of the American Urological Association.2010
- Author(s)
  Myers RP, Seki N, Gotoh M, Chai TC, Kaplan SA, Inoue K, Trachtenberg J, Kikuchi E, Nishiyama H, Chang SS, Lee C, Muto S, Ito K, Andriole GL, Eto M, Sumitomo M, Kamba T, Wood CG, Margulis V, Naito S, Egawa S.
- Journal Title
  
  International Journal of Urology
  
  Volume: 17(8) Pages: 743-752
- NAID
  10027259750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591793
[Journal Article] Etiology of overactive bladder and its therapeutic perspective--focusing on a myogenic basis for the overactive bladder2010
- Author(s)
  Kajioka S, Seki N, Shahab N, Yunoki T, Naito S.
- Journal Title
  
  Fukuoka Igaku Zasshi
  
  Volume: 101(5) Pages: 94-100
- Data Source
  KAKENHI-PROJECT-20599012
[Journal Article] Fifth joint meeting of the American Urological Association and the Japanese Urological Association International Affiliate Society Meeting at the 105th Annual Meeting of the American Urological Association2010
- Author(s)
  Myers RP, Seki N, Gotoh M, Chai TC, Kaplan SA, Inoue K, Trachtenberg J, Kikuchi E, Nishiyama H, Chang SS, Lee C, Muto S, Ito K, Andriole GL, Eto M, Sumitomo M, Kamba T, Wood CG, Margulis V, Naito S, Egawa S
- Journal Title
  
  Int J Urol
  
  Volume: 17(8) Pages: 745-753
- NAID
  10027259750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591793
[Journal Article] Etiology of overactive bladder and its therapeutic perspective--focusing on a myogenic basis for the overactive bladder2010
- Author(s)
  Kajioka S, Seki N, Shahab N, Yunoki T, Naito S
- Journal Title
  
  Fukuoka Acta Medica
  
  Volume: 101(5) Pages: 94-100
- Data Source
  KAKENHI-PROJECT-22591793
[Journal Article] 排尿障害治療薬2010
- Author(s)
  梶岡俊一、関成人.
- Journal Title
  
  新薬展望
  
  Volume: 101(5) Pages: 94-100
- Data Source
  KAKENHI-PROJECT-20599012
[Journal Article] The profiles and patterns of detrusor overactivity and their association with overactive bladder symptoms in men with benign prostatic enlarge ment associated with detrusor overactivity2009
- Author(s)
  Shahab N, Seki N, Takahashi R Kaiioka S, Takei M, Yamaguchi A, Naito S
- Journal Title
  
  Neurourology & Urodynamics (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599012
[Journal Article] The profiles and patterns of detrusor overactivity and their association with overactive bladder symptoms in men with benign prostatic enlargement associated with detrusor overactivity.2009
- Author(s)
  Shahab N, Seki N, Takahashi R, Kajioka S, Takei M, Yamaguchi A, Naito S.
- Journal Title
  
  Neurourol Urodyn 28(8)
  
  Pages: 953-958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599012
[Journal Article] Photoselective vaporization of the prostate : Outcome according to the prostate size in a series of 102 Japanese patients2009
- Author(s)
  Nomura H, Seki N, Yamaguchi A, Naito S
- Journal Title
  
  Int J Urol 16
  
  Pages: 87-90
- NAID
  10025195724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591857
[Journal Article] The profiles and patterns of detrusor overactivity and their association with overactive bladder symptoms in men with benign prostatic enlargement associated with detrusor overactivity2009
- Author(s)
  Shahab N, Seki N, Takahashi RKajioka S, Takei M, Yamaguchi A, Naito S
- Journal Title
  
  Neurourology & Urodynamics 28(8)
  
  Pages: 953-958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599012
[Journal Article] Effects of photoselectivevaporization of the prostate(PVP)onurodynamics in patients with benignprostatic enlargement2009
- Author(s)
  Seki N, Nomura H, Yamaguchi A, NaitoS
- Journal Title
  
  J Urol 180
  
  Pages: 1024-1029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591857
[Journal Article] Oscillatory membranecurrents paradoxically induced viaNO-activated pathways in pig detrusorcells2008
- Author(s)
  Kajioka S, Nakayama S, Seki N, Naito s, Brading AF
- Journal Title
  
  Cell Carcium 44
  
  Pages: 202-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591857
[Journal Article] Oscillatory membrane currents paradoxically induced via NO activated pathways in pig detrusor cells2008
- Author(s)
  Kaiioka S, Nakayama S, Seki N Naito S, Brading AF
- Journal Title
  
  Cell Calcium 44(2)
  
  Pages: 202-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599012
[Journal Article] Oscillatory membrane currents paradoxically induced via NO-activated pathways in pig detrusor cells2008
- Author(s)
  Kajioka S, Nakayama S, Seki N, et al
- Journal Title
  
  Cell Calcium 44
  
  Pages: 202-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591857
[Journal Article] Levcromakalim and MgGDP activate small conductance K<_ATP> Channels of Kir6. 1/SUR2A in pig detrusor smooth muscle cells : Uncoupling of cAMP signalpathways in pig detrusor cells2008
- Author(s)
  Kaiioka S, Nakayama S, Asano H, Seki N, Naito S, Brading AF
- Journal Title
  
  Journal of Pharmacology & Experimental Therapeutics 327(1)
  
  Pages: 114-123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599012
[Journal Article] Brading AF Levcromakalim and MgGDP activate small conductance ATP-sensitive K^+ channels of K^+ channel pore 6.1/sulfonylurea receptor 2A in pig detrusor smooth muscle cells : uncoupling of cAMP signal pathways.2008
- Author(s)
  Kajioka S, Nakayama S, Asano H, Seki N, Naito S
- Journal Title
  
  J Pharmacol Exp Ther. 327(1)
  
  Pages: 114-123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20599012
[Journal Article] Effects of flavoxate hydrochloride on voltage-dependent Ba_<2+> currents inhuman detrusor myocytes at different experimental temperatures2008
- Author(s)
  Tomoda T, Zhu HL, Iwasa K, Aishima M, Shibata A, Seki N, Naito S, Teramato N
- Journal Title
  
  Naunyn-Schmiedebergs Arch Pharmacol 376(3)
  
  Pages: 195-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591857
[Journal Article] Levcromakalim and MgGDP activate small conductance ATP-sensitive channels of K channel pore 6.1/sulfo-nylurea receptor 2A in pig detrusor smooth muscle cells : uncoupling of camp signal pathways2008
- Author(s)
  Kajioka S, Nakayama S, Seki N, et al
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics 327
  
  Pages: 114-123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591857
[Journal Article] Levcromakalim and MgGDP activate small conductance ATP-sensitive K channels of K channel pore 6.1/sulfonylurea receptor 2A in pig detrusor smooth muscle cells2008
- Author(s)
  Kajioka S, Nakayama S, Asano N, Seki N, Naito s, Brading AF
- Journal Title
  
  Uncoupling of cAMP signal pathways.J Pharmacol Exp Ther 327(1)
  
  Pages: 114-123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591857
[Journal Article] RhoA/Rho kinase-mediated Ca_<2+> sensitization in the contraction of human prostate2007
- Author(s)
  Takahashi R, Nishimura J, Seki N,Yunoki T, Tomoda T, Kanaide H, Naito S
- Journal Title
  
  Neurourol Urodyn 26(4)
  
  Pages: 547-551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591857
[Journal Article] The effects of flavoxate hydrochloride on voltage-dependent L-type Ca^<2+> currents in human urinary bladder.2005
- Author(s)
  N Seki et al.
- Journal Title
  
  Br J Pharmacol. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591694
[Journal Article] Ca^<2+> sensitization in contraction of human bladder smooth muscle.2004
- Author(s)
  Takahashi R, Nishimura J, Hirano K, Seki N, Naito S, Kanaide H
- Journal Title
  
  J Urol 172
  
  Pages: 748-752
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591694
[Journal Article] Ca^<2+> sensitization in contraction of human urinary bladder smooth muscle.2004
- Author(s)
  N Seki et al.
- Journal Title
  
  J.Urol. 172
  
  Pages: 748-752
- NAID
  10019219898
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591694
[Journal Article] Holmium laser enucleation for prostatic adenoma : analysis of learing curve over the course of consecutive 70 patients.2003
- Author(s)
  N Seki et al.
- Journal Title
  
  J.Urol. 170
  
  Pages: 1847-1850
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591694
[Journal Article] The effects of MCC-134 on the ATP-sensitive K^+ channels in pig urethra.2003
- Author(s)
  Yunoki T, Teramoto N, Takano N, Seki N, Creed KE, Naito S, Ito Y
- Journal Title
  
  Eur J Pharmacol 482(1-3)
  
  Pages: 287-295
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591694
[Journal Article] The effects of MCC-134 on the ATP-sensitive K^+ channels in pig urethra.2003
- Author(s)
  N Seki et al.
- Journal Title
  
  Eur.J.Pharmacol. 482(1-3)
  
  Pages: 287-295
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591694
[Journal Article] Holmiura laser enucleation for prostatic adenoma : analysis of learning curve over the course of 70 consecutive cases.2003
- Author(s)
  Seki N, Mochida O, Kinukawa N, Sagiyama K, Naito S
- Journal Title
  
  J Urol 170(5)
  
  Pages: 1847-1850
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591694
[Journal Article] The profiles and patterns of detrusor overactiviey and their associationwith overactive bladder symptoms inmen with benign prostatic enlargement associated with detrusor overactivity
- Author(s)
  Shahab N, Seki N, Takahashi R, Kajioka S, Takei M, Yamaguchi A, Naito S
- Journal Title
  
  Neurourol Urodyn (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591857
[Journal Article] The effects of flavoxate hydrochloride on voltage-dependent L-type Ca^<2+> currents in human urinary bladder.
- Author(s)
  Tomoda T, Aishima M, Takano N, Nakano T, Seki N, Yonemitsu Y, Sueishi K, Naito S, Ito Y, Teramoto N
- Journal Title
  
  Br J Pharmacol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591694
[Presentation] 「AMS GreenLightHPS」を用いた前立腺肥大症に対する蒸散術(PVP)の有用性に関する前向き研究2012
- Author(s)
  黒松功、桑原勝孝、伊原博行、鈴木和雄、野村博之、山口秋人、奥野博、関成人、内藤誠二、平尾佳彦、後藤百万、杉村芳樹
- Organizer
  第19回日本排尿機能学会
- Place of Presentation
  名古屋
- Year and Date
  2012-08-29
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] The effect of cyclic nucleotides on Ca sensitization induced by muscarinic stimulation in pig detrusor smooth muscle2012
- Author(s)
  Kajioka S, Shahab N, Takahashi R, Seki N, Naito S
- Organizer
  The 27^<th> Annual EAU Congress
- Place of Presentation
  Paris France
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] The efects of Mefloguine and Sorafenib on Carbachol induced oscillatory and tonic contraction in isolated pig detrusor smooth muscle.2012
- Author(s)
  ノウファルシャハブ、梶岡俊一、富永正周、柚木貴和、関成人、内藤誠二
- Organizer
  第99回日本泌尿器科学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] The effect of cyclic nucleotides on carbachol-induced calcium sensitization in contraction of alpha-toxin permeabilized human and pig detrusor smooth muscle2012
- Author(s)
  Kajioka S, Shahab N, Hayashi M, Takahashi R, Seki N, Naito S
- Organizer
  The 32^<nd> Congress of Societe internationale d'Urologie
- Place of Presentation
  Fukuoka Japan
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] 当院における120ワット高出力光選択的前立腺蒸散術(photoselective vaporization of the prostate: PVP)の効果と安全性に関する前向き研究2012
- Author(s)
  野村博之、関成人、山口秋人、内藤誠二
- Organizer
  第1回PVP研究会学術集会
- Place of Presentation
  横浜
- Year and Date
  2012-04-24
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] AMS GreenLight HPS」を用いた前立腺蒸散術(PVP)の有用性に関する前向き研究2012
- Author(s)
  桑原勝孝、野村博之、山口秋人、黒松功、伊原博之、関成人、奥野博、後藤百万、平尾佳彦、内藤誠二
- Organizer
  第26回日本泌尿器内視鏡学会総会
- Place of Presentation
  仙台
- Year and Date
  2012-11-22
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] 長谷川友紀クリニカルパスを用いた経尿道的前立腺切除術周術期管理の改善:多施設共同研究2012
- Author(s)
  岡村菊夫、野尻佳克、津島知靖、川喜田睦司、関成人、松田公志、荒井陽一、服部良平、内藤誠二
- Organizer
  第26回日本泌尿器内視鏡学会総会
- Place of Presentation
  仙台
- Year and Date
  2012-11-22
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] Rho-kinase pathway diminishes the relaxation effect of cyclic adenosine monophosphate on carbachol-induced calcium sensitization in contraction of a-toxin permeabilized Human detrusor smooth muscle2012
- Author(s)
  Kajioka S, Shahab N, Hayashi M, Takahashi R, Seki N, Naito S
- Organizer
  AUA Annual Meeting
- Place of Presentation
  Atlanta USA
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] ブタ及びヒト膀胱平滑筋でのトロポニン収縮蛋白による収縮機構の完成を試みる.2012
- Author(s)
  梶岡俊一、ノウファルシャハブ、柚木貴和、関成人、内藤誠二
- Organizer
  第99回日本泌尿器科学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] 高齢者における経尿道的前立腺蒸散術(TURisV)の安全性、有用性についての検討2012
- Author(s)
  高橋良輔、柚木貴和、林摩耶、ノーバルシャハブ、梶岡俊一、関成人、内藤誠二
- Organizer
  第25回日本老年泌尿器科学会
- Place of Presentation
  徳島
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] The muscarinic receptor subtype of M2 mediates Ca^<2+> sensitization via indirect activation of rho-kinase pathway in human detrusor smooth muscle2011
- Author(s)
  Kajioka S, Shahab N, Seki N, Naito S
- Organizer
  The 4^<1st> Annual Meeting of The International Continence Society
- Place of Presentation
  Glasgow, UK
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] シンポジウム7:前立腺肥大症診療ガイドライン-作成の経緯と今後の展望-タイトル「外科的治療法(手術ならびに低侵襲治療)について」2011
- Author(s)
  関成人
- Organizer
  第99回日本泌尿器科学会総会
- Place of Presentation
  名古屋
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] Photoselective Vaporization of The Prostate Versus Transurethral Resection of The Prostate : A Comparison of Improvement in Clinical Outcomes Following Surgery2011
- Author(s)
  Shahab N, Kajioka S, Seki N, Naito S
- Organizer
  The 29^<th> World Congress of Endourology (WCE) & SWL, Annual Meeting of the East Asian Society of Endourology, Annual Meeting of Japanese Society of Endourology
- Place of Presentation
  Kyoto–Japan
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] ディベート1:前立腺肥大症に対するレーザー治療PVP vs HoLEPタイトル「BPHに対する蒸散ならびに核出術の最適化に向けて」2011
- Author(s)
  関成人
- Organizer
  第25回日本泌尿器内視鏡学会
- Place of Presentation
  京都
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] The muscarinic receptor subtype of M2 mediates CA2+ sensitization via indirect activation of RHO-kinase pathway in human detrusor smooth muscle.2011
- Author(s)
  Shahab N, Kajioka S, Seki N, Naito S
- Organizer
  41st Annual Meeting of the International Continence Society
- Place of Presentation
  イギリス
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] サテライトセミナー2:Recent progress in the medical treatment of overactive bladder syndromeタイトル:「日本人のOAB治療-ASSIST試験の結果から-」2011
- Author(s)
  関成人
- Organizer
  第99回日本泌尿器科学会総会
- Place of Presentation
  名古屋
- Year and Date
  2011-04-21
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] シンポジウム7:「前立腺肥大症診療ガイドライン・下部尿路症状診療ガイドライン」タイトル:「BPHガイドラインの手術療法について」2011
- Author(s)
  関成人
- Organizer
  第61回日本泌尿器科学会中部総会
- Place of Presentation
  京都
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] The role of muscarinic receptors in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle2011
- Author(s)
  Shahab N, Kajioka S, Seki N, Naito S
- Organizer
  26^<th> Annual Congress of The European Association of Urology
- Place of Presentation
  Vienna, Austria(Best presentation award)
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] シンポジウム3:新時代の前立腺肥大症治療タイトル:「手術療法の新展開」2011
- Author(s)
  関成人
- Organizer
  第18回日本排尿機能学会
- Place of Presentation
  福井
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] The features of oscillating currents observed in detrusor smooth muscle2010
- Author(s)
  Shunichi kajioka, Nouval Shahab, Shinsuke Nakayama, Hiromitsu Morita, Narihito Seki, Seiji Naito
- Organizer
  Smooth Muscle Rhythm The 6th International symposium on ICC
- Place of Presentation
  Miyazaki Japan
- Data Source
  KAKENHI-PROJECT-20599012
[Presentation] The enhancement of Rho kinase pathway and the decrement of protein kinase C pathway in carbachol-induced calcium sesitization in α toxin permeabilized guinea pig detrusor smooth muscle following bladder outlet obstruction.2010
- Author(s)
  Nouval S, Kajioka S, Seki N, Takahashi R, Yunoki T, Naito S
- Organizer
  AUA 105th Annual Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2010-05-03
- Data Source
  KAKENHI-PROJECT-20599012
[Presentation] 下部尿路に対する内視鏡的診断・治療の最前線KTP laserを用いた光選択的前立腺蒸散術2010
- Author(s)
  関成人
- Organizer
  第24回日本Endourology・ESWL学会総会
- Place of Presentation
  京都
- Year and Date
  2010-10-21
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] KTPレーザーを用いた光選択的前立腺蒸散術(PVP)の臨床成績2010
- Author(s)
  関成人、野村博之、山口秋人、内藤誠二
- Organizer
  第98回日本泌尿器科学会総会
- Place of Presentation
  盛岡
- Year and Date
  2010-04-27
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] 高齢者に対する光選択的レーザー蒸散術(PVP)の検討2010
- Author(s)
  関成人、野村博之、柚木貴和、高橋良輔、山口秋人、内藤誠二
- Organizer
  第23回日本老年泌尿器科学会
- Place of Presentation
  東京
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] Bladder outlet obstruction modulates Ca2+ sensitization in α toxin permeabilized guinea pig detrusor smooth muscle.2010
- Author(s)
  Nouval S, Kajioka S, Seki N, Naito S
- Organizer
  AUA 105th Annual Meeting
- Place of Presentation
  Marrakech, Morocco
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-20599012
[Presentation] 前立腺肥大症(BPH)に対する経尿道的手術:尿流動態因子と治療効果の関連2010
- Author(s)
  関成人、野村博之、山口秋人、梶岡俊一、柚木貴和、Nouval Shahab、内藤誠二
- Organizer
  第17回日本排尿機能学会
- Place of Presentation
  甲府
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] Male LUTS "Management of male LUIS : how optimized and different between countries?"2010
- Author(s)
  Seki N, Gotoh M, Chai TC, Kaplan SA
- Organizer
  5th AUA/JUA International Affiliate Society Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2010-05-03
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] Laser treatment of BPH : Holep & PVP.2010
- Author(s)
  Seki N
- Organizer
  10th Asian Congress of Urology of the Urological Association of Asia
- Place of Presentation
  Taipei Taiwan
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] 日本におけるBPH/OAB治療戦略-ASSIST試験からの知見-2010
- Author(s)
  関成人
- Organizer
  第62回日本泌尿器科学会西日本総会
- Place of Presentation
  鹿児島
- Year and Date
  2010-11-04
- Data Source
  KAKENHI-PROJECT-22591793
[Presentation] ヒト及びブタ膀胱排尿筋のATP感受性Kチャネルの比較検討2009
- Author(s)
  梶岡俊一, Nouval Shahab, 森田浩光, 杉原恵美, Alison Brading, 関成人, 内藤誠二
- Organizer
  第51回日本平滑筋学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20599012
[Presentation] 多チャンネル同時記録測定微小電極アレイの導入によるモルモット膀胱排尿筋の自発活動電位の新しい評価法2009
- Author(s)
  梶岡俊一, Nouval Shahab, 中山晋介, 高橋良輔, 柚木貴和, 関成人, 内藤誠二
- Organizer
  第16回日本排尿機能学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20599012
[Presentation] -nicotineamide adenine dinucleotide activates an ATP-sensitive potassiumss channel of human urinary bladder2009
- Author(s)
  梶岡俊一, Nouval Shahab, 森田浩光, 杉原恵美, Alison Brading, 関成人, 内藤誠二
- Organizer
  The 36th International Congress of Physiological Sciences, International Union of Physiological Sciences
- Place of Presentation
  Kyoto Japan
- Data Source
  KAKENHI-PROJECT-20599012
[Presentation] ヒト膀胱排尿筋のATP感受性Kチャネルは、β-nicotine amide adenine diphosphate(βNAD)によって活性化される2009
- Author(s)
  梶岡俊一, Nouval Shahab, 中山晋介, 高橋良輔, 柚木貴和, 関成人, 内藤誠二
- Organizer
  第97回日本泌尿器科学会総会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20599012
[Presentation] Obstruction enhances Rho-kinase pathway in carbachol-induced Ca2+ sensitization in alpha-toxin permeabilized guinea-pig detrusor smooth muscle2009
- Author(s)
  Nouval Shahab, 梶岡俊一, 高橋良輔, 関成人, 内藤誠二
- Organizer
  39th Annual Meeting of the International Continence Society
- Place of Presentation
  San Fransisco, USA
- Data Source
  KAKENHI-PROJECT-20599012
[Presentation] -Nicotinamide adeninediphosphate activates an ATP-sensitive potassium channel in the single channel study of human urinary bladder smooth muscle cells2009
- Author(s)
  梶岡俊一, Nouval Shahab, 森田浩光, 杉原恵美, Alison Brading, 関成人, 内藤誠二
- Organizer
  American Urological Association, Annual Meeting
- Place of Presentation
  Chicago USA
- Data Source
  KAKENHI-PROJECT-20599012
[Presentation] Comprehensive studies of ATP-sensitive potassium channels in pig and human detrusor smooth muscle cells.2008
- Author(s)
  Seki N, Kajioka S, et al.
- Organizer
  International Continence Society
- Place of Presentation
  Cairo Egypt
- Data Source
  KAKENHI-PROJECT-20599012
[Presentation] RhoA/Rho kinase mediated Ca2+ sensitization in the contraction of human prostate.2008
- Author(s)
  Takahashi R, Seki N, Naito S
- Organizer
  The 3rd Pan-Pacific Continence Society Meeting
- Place of Presentation
  Taiwan, Chang-GungMemorial Hospital
- Year and Date
  2008-09-26
- Data Source
  KAKENHI-PROJECT-19591857
[Presentation] 亜硝酸薬による膀胱排尿筋の逆説的収縮機構の解明2008
- Author(s)
  梶岡俊一、関成人、中山晋介、高橋良輔、Nouval Shahab Alison Brading、内藤誠二
- Organizer
  第16回日本排尿機能学会
- Place of Presentation
  東京
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-20599012
[Presentation] ムスカリン受容体を介した排尿筋の持続性収縮における膜電流の包括的検討2008
- Author(s)
  関成人、他
- Organizer
  第96回日本泌尿器科学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-04-25
- Data Source
  KAKENHI-PROJECT-19591857
[Presentation] 亜硝酸薬による膀胱排尿筋の逆説的収縮機構の解明.2008
- Author(s)
  梶岡俊一, 関成人, 他
- Organizer
  第15回日本排尿機能学会
- Place of Presentation
  東京大手町サンヶィプラザ
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-19591857
[Presentation] ムスカリン受容体を介した排尿筋の持続性収縮における膜電流の包括的検討.2008
- Author(s)
  関成人, 梶岡俊一, 他
- Organizer
  第96回日本泌尿器科学会総会
- Place of Presentation
  横浜パシフィコ横浜
- Year and Date
  2008-04-27
- Data Source
  KAKENHI-PROJECT-19591857
[Presentation] Comprehensive studies of ATP-sensitive potassium channels in pig and human detrusor smooth muscle cells2008
- Author(s)
  Seki N, Kajioka S, et.al.
- Organizer
  International Continence Society 2008
- Place of Presentation
  Egypt
- Year and Date
  2008-10-20
- Data Source
  KAKENHI-PROJECT-19591857
[Presentation] 亜硝酸薬による膀胱排尿筋の逆説的収縮機構の解明2008
- Author(s)
  梶岡俊一、関成人、高橋良輔、他
- Organizer
  第15回日本排尿機能学会
- Place of Presentation
  東京
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-19591857
[Presentation] Enhancement of the contractile responses of detrusor muscle by thrombin and trypsin in the cyclophosphamide-induced cystitismodel of mice2008
- Author(s)
  Shiga K, Seki N, Naito S
- Organizer
  第60回日本泌尿器科学会西日本総会
- Place of Presentation
  北九州
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-19591857
[Presentation] RhoA/Rho kinase mediated Ca2^+ sensitization in the contraction of human prostate2008
- Author(s)
  Takahashi R, Seki N, Naito S
- Organizer
  The 3rd Pan-Pacific Continence SocietyMeeting
- Place of Presentation
  Taiwan
- Year and Date
  2008-09-26
- Data Source
  KAKENHI-PROJECT-19591857
[Presentation] ヒト膀胱および前立腺におけるRho-kinaseの発現と機能2007
- Author(s)
  関成人
- Organizer
  第14回日本排尿機能学会
- Place of Presentation
  福島県猪苗代町
- Year and Date
  2007-10-06
- Data Source
  KAKENHI-PROJECT-19591857
[Presentation] ヒト膀胱および前立腺におけるRho-kinaseの発現と機能2007
- Author(s)
  関成人、他
- Organizer
  第14回日本排尿機能学会
- Place of Presentation
  福島
- Year and Date
  2007-10-16
- Data Source
  KAKENHI-PROJECT-19591857
[Presentation] ブタ及びヒト膀胱平滑筋でのトロポニン収縮蛋白による収縮機構の完成を試みる
- Author(s)
  梶岡俊一, Nouval Shahab ,柚木貴和,関成人,内藤誠二
- Organizer
  第99回日本泌尿器科学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] Detection of cardiac troponin T in detrusor smooth muscle. -Does troponin system operate in smooth muscle?-
- Author(s)
  Kajioka S, Takahashi-Yanaga F, Shahab N, Takahashi R, Matsuda M, Yonemitsu Y, Seki N, Nakayama S, Naito S
- Organizer
  第84回日本薬理学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] Generosity of cardiac troponin T in smooth muscle and its functional analysis in detrusor smooth muscle
- Author(s)
  Kajioka S, Shahab N, Takahashi-Yanaga F, Takahashi R, Matsuda M, Yonemitsu Y, Seki N, Nakayama S
- Organizer
  第88回日本生理学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592371

1. KAJIOKA Syunichi (90274472)

# of Collaborated Projects: 4 results

# of Collaborated Products: 51 results
2. ITO Yushi (80037506)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. NAKAYAMA Shinsuke (30192230)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
4. TERAMOTO Noriyoshi (40294912)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. TAKAHASHI Ryousuke (30529805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. ITO Shinichi (00315095)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
7. TAKAHASHI Fumi (50274436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ITO Shinichi (40291520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
9. YONEMITSU Yoshikazu (40315065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. NISHIMURA Junji (90237727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. TAKANO Makoto (30236252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 弥永富美

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results

SEKI Narihito 関 成人

関 成人 セキ ナリヒト

Research Projects

Research Products

Co-Researchers

The basic research for the novel treatment for under active bladder -focusing on the construction of troponin system in smooth muscle-

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The morphological and physiological investigation into the interstitial cells of human and guinea-pig urinary bladder.Principal Investigator

Principal Investigator

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The investigation into the molecular and electrophysiological properties of overactive bladder and the research for the novel consequent treatment

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

The correlation between bladder outlet obstruction and calcium sensitization mechanism in human and guinea pig detrusor smooth musclePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Molecular and pharmacological studies of human vascular-type ATP-sensitive K+ channels regarding the channel kinetics

Principal Investigator

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Ca^<2+> sensitization of human and rabbit urinary bladder smooth musclePrincipal Investigator

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Research Institution

Molecular and pharmacological investigation of ATP-sensitive K^+ channels in human detrusor

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Passive membrane electrical property and neuro-muscular transmission in human detrusor smooth musclePrincipal Investigator

Principal Investigator

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[Journal Article] Functional role of muscarinic receptor subtypes in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle2012

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[Journal Article] TURP術後の最適なカテーテル抜去日2012

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NAID

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[Journal Article] Endogenous cardiac troponin T modulates Ca^<2+> -mediated smooth muscle contraction2012

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[Journal Article] Obstruction enhances rho-kinase pathway and diminishes protein kin-ase C pathway in carbachol-induced calcium sensitization in contraction of α-toxin permeabilized guinea pig detrusor smooth muscle2012

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[Journal Article] Japanese Society Of Endourology Laparoscopic Partial Nephrectomy Study Group: Surgical and oncologic outcomes of laparoscopic partial nephrectomy: a Japanese multi-institutional study of 1375 patients2012

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[Journal Article] Obstruction enhances rho-kinase pathway and diminishes protein kinse C pathway in carbachol-induced calcium sensitization in α-toxin permeabilized Guinea pig detrusor smooth muscle2012

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[Journal Article] Endogenous cardiac troponin T modulates Ca(2+)-mediated smooth muscle contraction2012

SEKI Narihito 関成人

関成人セキナリヒト