Yamaguchi Hiroki 山口博樹

… Alternative Names

YAMAGUCHI Hiroki 山口博樹

山口博樹ヤマグチヒロキ

Less

Researcher Number	90297937
Other IDs
External Links
Affiliation (Current)	2025: 日本医科大学, 大学院医学研究科, 大学院教授 2025: 日本医科大学, 医学部, 大学院教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 日本医科大学, 大学院医学研究科, 大学院教授 2021 – 2023: 日本医科大学, 医学部, 大学院教授 2018 – 2019: 日本医科大学, 医学部, 准教授 2017: 日本医科大学, 医学部, 助手 2016: 日本医科大学, 医学部, 准教授 … More 2013 – 2014: 日本医科大学, 医学部, 准教授 2012: 日本医科大学, 医学部, 講師 2007 – 2008: Nippon Medical School, 医学部, 助教 2004 – 2005: 日本医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 52040:Radiological sciences-related / Basic Section 52020:Neurology-related / Hematology
Keywords	Principal Investigator 遺伝子変異 / 急性骨髄性白血病 / Born marrow failure / polymorphisms / mutation / telomere length / telomerase reverse transcriptase subunit gene / human telomerase RNA gene / Dyskeratosis congenita / ミトコンドリア活性 … More / MCL-1 / ベネトクラクス耐性 / シタラビン耐性 / FLT3-ITD / NPM1変異 / ミトコンドリアDNAコピー数 / テロメア / 遺伝子 / DNAヘリカーゼ遺伝子 / ACD / TEP1 / TEP1遺伝子 / TINF2遺伝子 / ACD遺伝子 / 新規遺伝子変異 / テロメラーゼ活性 / テロメア制御遺伝子異常 / 先天性角化不全症 / ＣＡＰ１ / CAP1 / Bone marrow failure / Telomere length / Mutation / TINF2 gene / SBDS gene / Telomerase reverse transcriptase subunit gene / Dyskariotosis Congenita / born marrow failure / Japanese / Polymorphisms … More Except Principal Investigator 急性骨髄性白血病 / RAD51 / DNA修復機構 / DNMT3A変異 / アポトーシス / BCL2阻害剤 / 白血病 / 画像所見 / 脳卒中関連遺伝子 / ゲノム疫学研究 / 脳血管障害 / BBJ / 脳梗塞関連遺伝子 / バイオバンクジャパン / 脳梗塞 / 疫学 / ゲノム解析 / lats / mutation / YAP / leukemic stem cell / Hippo Pathway / Hippo pathway / 白血病幹細胞 Less

脳卒中のAI画像解析とポリジェニックモデルによる関連遺伝子座の相関性分析
- Principal Investigator
  
  青木淳哉
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Nippon Medical School
BCL-2阻害剤抵抗性白血病における抗アポトーシス分子スイッチングの機序解明
- Principal Investigator
  
  永田安伸
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nippon Medical School
Clinical significance and development of new target treatment of activated mitochondrial function in acute myeloid leukemiaPrincipal Investigator
- Principal Investigator
  
  山口博樹
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nippon Medical School
DNMT3A変異陽性AMLに生じるG2/M期の遺伝子発現異常とその標的治療の開発
- Principal Investigator
  
  脇田知志
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nippon Medical School
Association between genetic risk for stroke and clinical characteristics in Japanese stroke patients
- Principal Investigator
  
  Shimoyama Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nippon Medical School
The analysis of gene mutation acquisition and chemotherapy resistant mechanism by Hippo pathway of leukemia stem cells
- Principal Investigator
  
  Inokuchi Koiti
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
The identification of the novel gene mutation and development of the novel therapy for dyskeratosis congenitaPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Hiroki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
The pathogenesis of acute myeloid leukemia due to the CAP1 gene mutation.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Hiroki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
Analysis of pathogenesis mechanism and development of new treatment in bone marrow failure due to mutation of telomere regulated genes.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Hiroki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School
骨髄不応性疾患におけるテロメラーゼ複合体遺伝子群の塩基配列変異の関連性についてPrincipal Investigator
- Principal Investigator
  
  山口博樹
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Nippon Medical School

All 2023 2022 2019 2018 2017 2016 2014 2013 2012 2008 2007 2006 Other

All Journal Article Presentation Book

[Book] Annual Review 血液 2006(テロメラーゼ複合体遺伝子異常と骨髄不全症)2006
- Author(s)
  山口博樹
- Total Pages
  278
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-16790548
[Journal Article] Significance of FLT3-tyrosine kinase domain mutation as a prognostic factor for acute myeloid leukemia.2019
- Author(s)
  Sakaguchi M, Yamaguchi H, Kuboyama M, Najima Y, Usuki K, Ueki T, Oh I, Mori S, Kawata E, Uoshima N, Kobayashi Y, Kako S, Tajika K, Shono K, Kayamori K, Hagihara M, Kanda J, Uchiyama H, Kuroda J, Uchida N, Kubota Y, Kimura S, Kurosawa S, et al
- Journal Title
  
  Int J Hematol
  
  Volume: 110 Issue: 5 Pages: 566-574
- DOI
  10.1007/s12185-019-02720-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09851, KAKENHI-PROJECT-17K09942
[Journal Article] Fatal Acute Exacerbation of Familial Interstitial Pneumonia Complicated with Dyskeratosis Congenita after Influenza Virus B Infection.2019
- Author(s)
  Tachiwada T, Oda K, Tahara M, Sennari K, Nemoto K, Noguchi S, Kawanami T, Kido T, Yamaguchi H, Yatera K.
- Journal Title
  
  Inter Med.
  
  Volume: 印刷中
- NAID
  130007706914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09832
[Journal Article] Importance of prognostic stratification via gene mutation analysis in elderly patients with acute myelogenous leukemia2019
- Author(s)
  Fujiwara Yusuke、Yamaguchi Hiroki、Inokuchi Koiti, et al.
- Journal Title
  
  International Journal of Laboratory Hematology
  
  Volume: 41 Issue: 4 Pages: 461-471
- DOI
  10.1111/ijlh.13025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09942
[Journal Article] Usefulness of BCOR gene mutation as a prognostic factor in acute myeloid leukemia with intermediate cytogenetic prognosis.2018
- Author(s)
  Terada K, Yamaguchi H, Ueki T, et al.
- Journal Title
  
  Genes, Chromosomes and Cancer
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09942
[Journal Article] Prognostic impact of low allelic ratio FLT3-ITD and NPM1 mutation in acute myeloid leukemia.2018
- Author(s)
  Sakaguchi M, Yamaguchi H, Najima Y, Usuki K, Ueki T, Oh I, Mori S, Kawata E, Uoshima N, Kobayashi Y, Kako S, Tajika K, Gomi S, Shono K, Kayamori K, Hagihara M, Kanda J, Uchiyama H, Kuroda J, Uchida N, Kubota Y, Kimura S, et al.
- Journal Title
  
  Blood Advances
  
  Volume: 2 Issue: 20 Pages: 2744-2754
- DOI
  10.1182/bloodadvances.2018020305
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09851, KAKENHI-PROJECT-17K09942
[Journal Article] Usefulness of BCOR gene mutation as a prognostic factor in acute myeloid leukemia with intermediate cytogenetic prognosis2018
- Author(s)
  Terada Kazuki、Yamaguchi Hiroki、Ueki Toshimitsu, et al.
- Journal Title
  
  Genes, Chromosomes and Cancer
  
  Volume: 57 Issue: 8 Pages: 401-408
- DOI
  10.1002/gcc.22542
- Data Source
  KAKENHI-PROJECT-17K09942
[Journal Article] Clinical features and prognostic impact of PRDM16 expression in adult acute myeloid leukemia2017
- Author(s)
  Yamato Genki、Yamaguchi Hiroki、Handa Hiroshi、Shiba Norio、Kawamura Machiko、Wakita Satoshi、Inokuchi Koiti、Hara Yusuke、Ohki Kentaro、Okubo Jun、Park Myoung-Ja、Sotomatsu Manabu、Arakawa Hirokazu、Hayashi Yasuhide
- Journal Title
  
  Genes, Chromosomes and Cancer
  
  Volume: 56 Issue: 11 Pages: 800-809
- DOI
  10.1002/gcc.22483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10050, KAKENHI-PROJECT-17K09942, KAKENHI-PROJECT-17K10130, KAKENHI-PROJECT-16K20951
[Journal Article] D816V mutation in the KIT gene activation loop has greater cell-proliferative and anti-apoptotic ability than N822K mutation in core-binding factor acute myeloid leukemia2017
- Author(s)
  Omori Ikuko、Yamaguchi Hiroki、Miyake Koichi、Miyake Noriko、Kitano Tomoaki、Inokuchi Koiti
- Journal Title
  
  Experimental Hematology
  
  Volume: 52 Pages: 56-64.e4
- DOI
  10.1016/j.exphem.2017.05.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09604, KAKENHI-PROJECT-17K09942, KAKENHI-PROJECT-26461596
[Journal Article] 骨髄不全症におけるテロメア制御異常2017
- Author(s)
  山口博樹
- Journal Title
  
  血液フロンティア
  
  Volume: 27 Pages: 5-9
- Data Source
  KAKENHI-PROJECT-16K09832
[Journal Article] D816 mutation of the KIT gene in core binding factor acute myeloid leukemia is associated with poorer prognosis than other KIT gene mutations2017
- Author(s)
  Yui Shunsuke、Kurosawa Saiko、Yamaguchi Hiroki、et al.
- Journal Title
  
  Annals of Hematology
  
  Volume: 96 Issue: 10 Pages: 1641-1652
- DOI
  10.1007/s00277-017-3074-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09942
[Journal Article] Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes.2017
- Author(s)
  Muramatsu H, Okuno Y, Yoshida K, Shiraishi Y, Doisaki S, Narita A, Sakaguchi H, Kawashima N, Wang X, Xu Y, Chiba K, Tanaka H, Hama A, Sanada M, Takahashi Y, Kanno H, Yamaguchi H, Ohga S, Manabe A, Harigae H, Kunishima S, Ishii E, Kobayashi M, Koike K, Watanabe K, Ito E, Takata M, Yabe M, Ogawa S, Miyano S, Kojima S.
- Journal Title
  
  Genet Med.
  
  Volume: - Issue: 7 Pages: 796-802
- DOI
  10.1038/gim.2016.197
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-15H01738, KAKENHI-PROJECT-26253061, KAKENHI-PROJECT-26293225, KAKENHI-PROJECT-15K09647, KAKENHI-PROJECT-16K09832, KAKENHI-PROJECT-16K10041, KAKENHI-PROJECT-15H04874
[Journal Article] Full-length mutation search of the TP53 gene in acute myeloid leukemia has increased significance as a prognostic factor2017
- Author(s)
  Terada Kazuki、Yamaguchi Hiroki、Ueki Toshimitsu、et al.
- Journal Title
  
  Annals of Hematology
  
  Volume: 97 Issue: 1 Pages: 51-61
- DOI
  10.1007/s00277-017-3143-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09942
[Journal Article] Hoyeraal-Hreidarsson syndrome in a patient with novel compound heterozygous RTEL1 gene mutations.2016
- Author(s)
  Moriya K, Suzuki T, Watanabe Y, Saito-Nanjo Y, Niizuma H, Onuma M, Rikiishi T, Kakuta F, Abukawa D, Yamaguchi H, Sasahara1 Y, Kure S.
- Journal Title
  
  Pediatric Blood &Cancer.
  
  Volume: 63 Issue: 9 Pages: 1683-1684
- DOI
  10.1002/pbc.26030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09832
[Journal Article] nhibition of S100A6 induces graft versus leukemia effects in MLL/AF4-positive ALL in human PBMC-SCID mice.2014
- Author(s)
  Tamai.H, Miyake K, Yamaguchi H, Shimada T, Dan K, Inokuchi K.
- Journal Title
  
  Bone Marrow Transplantation
  
  Volume: 49(5) Issue: 5 Pages: 699-703
- DOI
  10.1038/bmt.2014.18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591412, KAKENHI-PROJECT-24591529, KAKENHI-PROJECT-26461434, KAKENHI-PROJECT-26461596
[Journal Article] 急性骨髄性白血病とエピジェネティクス制御関連遺伝子変異2014
- Author(s)
  脇田知志、山口博樹
- Journal Title
  
  日本臨床
  
  Volume: 72(6) Pages: 1026-1032
- Data Source
  KAKENHI-PROJECT-24591412
[Journal Article] Granulocyte colony-stimulating factor combined regimen in cord blood transplantation for acute myeloid leukemia: a nationwide retrospective analysis in Japan.2014
- Author(s)
  1.Konuma T, Ooi J, Uchida N, Ogawa H, Ohashi K, Kanamori H, Aotsuka N, Onishi Y, Yamaguchi H, Kozai Y, Nagamura-Inoue T, Kato K, Suzuki R, Atsuta Y, Kato S, Asano S, Takahashi S.
- Journal Title
  
  Haematologica
  
  Volume: 99(12) Issue: 12 Pages: e264-e268
- DOI
  10.3324/haematol.2014.114504
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591412, KAKENHI-PROJECT-24591434, KAKENHI-PROJECT-25893049
[Journal Article] Mutations of the Epigenetics Modifying Gene (DNMT3a, TET2, IDH1/2) at Diagnosis may Induce FLT3-ITD at Relapse in de novo Acute Myeloid Leukemia2013
- Author(s)
  Yamaguchi H, Wakita S, Omori I, et al.
- Journal Title
  
  Leukemia
  
  Volume: 27(5) Issue: 5 Pages: 1044-1052
- DOI
  10.1038/leu.2012.317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591412
[Journal Article] AML再発時におけるエピジェネティック関連遺伝子変異の意義.2013
- Author(s)
  脇田知志, 山口博樹.
- Journal Title
  
  血液内科
  
  Volume: 67(5) Pages: 651-661
- NAID
  40019901763
- Data Source
  KAKENHI-PROJECT-24591412
[Journal Article] Mutations of the Epigenetics Modifying Gene (DNMT3a, TET2, IDH1/2) at Diagnosis may Induce FLT3-ITD at Relapse in de novo Acute Myeloid Leukemia.2013
- Author(s)
  Wakita S, Yamaguchi H Omori I, Terada K, Ueda T, Manabe E, Kurosawa S, Iida S, Ibaraki T, Sato Y, Todoroki T, Hirakawa T, Ryotokuji T, Arai K, Kitano T, Mitamura Y, Kosaka F, Dan K, Inokuchi K.
- Journal Title
  
  Leukemia.
  
  Volume: 27(5) Pages: 1044-1052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591412
[Journal Article] 急性骨髄性白血病の今後の展望20132013
- Author(s)
  山口博樹
- Journal Title
  
  臨床血液
  
  Volume: 54(1) Pages: 39-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591412
[Journal Article] テロメア異常と骨髄不全症2008
- Author(s)
  山口博樹
- Journal Title
  
  日本臨床 66
  
  Pages: 483-489
- Data Source
  KAKENHI-PROJECT-19591141
[Journal Article] 再生不良性貧血の分子病態2008
- Author(s)
  山口博樹, 猪口孝一
- Journal Title
  
  血液・腫瘍科 56
  
  Pages: 155-161
- Data Source
  KAKENHI-PROJECT-19591141
[Journal Article] Identification and functional characterization of novel telomerase variant alleles in Japanese patients with bone-marrow failure syndromes2008
- Author(s)
  Takeuchi J, Ly H, Yamaguchi H, Carroll KA, Kosaka F, Sawaguchi K, Mitamura Y, Watanabe A, Gomi S, Inokuchi K, Dan K
- Journal Title
  
  Blood Cells Mol Dis. 40 (2)
  
  Pages: 185-91
- Data Source
  KAKENHI-PROJECT-19591141
[Journal Article] Identification and functional characterization of novel telomerase variant alleles in Japanese patients with bone-marrow failure syndromes.2008
- Author(s)
  Takeuchi J^*, Ly H^*, Yamaguchi H
- Journal Title
  
  Blood Cells Mol Dis. 40
  
  Pages: 185-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591141
[Journal Article] 再生不良性貧血のゲノム解析2007
- Author(s)
  山口博樹
- Journal Title
  
  分子細胞治療 6
  
  Pages: 467-471
- Data Source
  KAKENHI-PROJECT-19591141
[Journal Article] Mutations of telomerase complex genes linked to bone marrow failures2007
- Author(s)
  Yamaguchi H
- Journal Title
  
  J Nippon Med Sch 74
  
  Pages: 202-9
- NAID
  130004057301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591141
[Journal Article] Mutations of telomerase complex genes linked to bone marrow failures2007
- Author(s)
  Yamaguchi H.
- Journal Title
  
  J Nippon Med Sch. 74 (3)
  
  Pages: 202-9
- NAID
  130004057301
- Data Source
  KAKENHI-PROJECT-19591141
[Presentation] Mitochondrial DNA copy number stratified the prognosis of NPM1/FLT3 mutated AML2023
- Author(s)
  小島祐依, 脇田知志, 下平統英, 丸毛淳史, 森田薫, 賀古真一, 土岐典子, 諫田淳也, 黒田純也, 森慎一郎, 佐竹敦志, 臼杵憲祐, 植木俊充, 魚嶋伸彦, 河田英里, 中山一隆, 永尾侑平, 鐘野勝洋, 澁澤基治, 木村晋也, 一戸辰夫, 本村小百合, 橋本朗子, 佐藤恵理子, 緒方正男, 安藤純, 田代晴子, 阪口正洋, 神田善伸, 山口博樹
- Organizer
  第85回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-23K07821
[Presentation] Sex-specific differences in risk profiles for cancer among 19702 Japanese patients with ischemic stroke: The BioBank Japan project2022
- Author(s)
  Takashi Shimoyama, Koichi Matsuda, Yoichiro Kamatani, Yasunobu Nagata, Hiroki Yamaguchi, Kazumi Kimura
- Organizer
  International Stroke Conference 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07445
[Presentation] 19702人の日本人虚血性脳卒中患者における悪性腫瘍の危険因子と性特異的相違に関する検討ーバイオバンク・ジャパン研究事業ー2022
- Author(s)
  下山　隆、鎌谷洋一郎、松田浩一、永田安伸、山口博樹、木村和美
- Organizer
  第48回日本脳卒中学会学術集会ーSTROKE 2023ー
- Data Source
  KAKENHI-PROJECT-21K07445
[Presentation] Identification of high-risk acute myeloid leukemia2019
- Author(s)
  Yamaguchi Hiroki
- Organizer
  The 24th Congress of APBMT 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09942
[Presentation] Efficacy of allo-HSCT in CR1 for low allelic ratio FLT3-ITD and NPM1 mutation in AML.2019
- Author(s)
  Masahiro Sakaguchi, Hiroki Yamaguchi, Koiti Inokuchi, et al.
- Organizer
  第41回日本造血細胞移植学会総会.
- Data Source
  KAKENHI-PROJECT-17K09942
[Presentation] The importance of minimal residual disease analysis using genetic mutations in diagnosis and remission of acute myeloid leukemia2019
- Author(s)
  Yamaguchi Hiroki
- Organizer
  第81回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09942
[Presentation] 急性骨髄性白血病におけるFLT3-ITDアレル比の予後因子としての重要性2017
- Author(s)
  Nana Nakajima, Hiroki Yamaguchi, Toshimitsu Ueki, et al.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09942
[Presentation] DKCの診断におけるTERT遺伝子変異の機能解析の重要性2017
- Author(s)
  Kazuki Terada, Hiroki Yamaguchi, Koichi Miyake, Noriko Miyake, Yoshiki Osaki, Takashi Okada, Seiji Kojima, Etsuro Ito, Koiti Inokuchi.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09832
[Presentation] RUNX1変異陽性急性骨髄性白血病の臨床的特徴と治療成績2017
- Author(s)
  Nakagome Shun, Hiroki Yamaguchi, Toshimitsu Ueki, et al.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09942
[Presentation] 急性骨髄性白血病における微少残存病変としてのNPM1変異高感度検出法の有用性2017
- Author(s)
  Atsushi Marumo, Hiroki Yamaguchi, Satoshi Yamanaka, et al.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09942
[Presentation] The clinical features and prognostic impact of DNMT3A gene mutation in Japanese patients with de novo AML2012
- Author(s)
  Ryotokuji T, Yamaguchi H, Omori I, Hirakawa T, Wakita S, Arai K, Kitano T, Mitamura Y, Kosaka F, Shimada T, Inokuchi K, Dan K.
- Organizer
  The 3rd JSH International Symposium
- Place of Presentation
  Kawagoe
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] Stability of gene mutation in relapsed acute myeloid leukemia.2012
- Author(s)
  Wakita S, Yamaguchi H, Omori I, Hirakawa T, Kitano T, Arai K, Mitamura Y, Kosaka F, Inokuchi K, Dan K.
- Organizer
  The 3rd JSH International Symposium
- Place of Presentation
  Kawagoe
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] Comparative analysis of BHAC regimen and 3+7 regimen as induction for de novo acute myeloid leukemia2012
- Author(s)
  Fukunaga K, Yamaguchi H, Ryotokuji T, Hirakawa T, Wakita S, Tamai H, Nakayama K, Nakamura K, Inokuchi K, Dan K.
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The prognostic impact of Flt3 mutation in acute promyelocytic leukemia2012
- Author(s)
  Hirakawa T, Yamaguchi H, Wakita S, Ryotokuji T, Kosaka F, Kitano T, Arai K, Omori I, Sato Y, Todoroki T, Dan K, Inokuchi K.
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The clinical features and prognostic impact of DNMT3A gene mutation in Japanese patients with de novo AML2012
- Author(s)
  Wakita S, Yamaguchi H, Ryotokuji T, Takeuchi J, Omori I, Hirakawa T, Kitano T, Mitamura Y, Kosaka F, Inokuchi K, Dan K.
- Organizer
  17th congress of the European hematology Association
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The clinical features and prognostic impact of DNMT3A gene mutation in Japanese patients with de novo AML2012
- Author(s)
  Ryotokuji T, Yamaguchi H, Usuki K, Tajika K, Gomi S, Omori I, Sato Y, Todoroki T, Arai K, Kitano T, Mitamura Y, Kosaka F, Hirakawa T, Wakita S, Inokuchi K, Dan K.
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The clinical features and prognostic impact of de novo acute myeloid leukemia with MLL-PTD2012
- Author(s)
  Todoroki T, Yamaguchi H, Usuki K, Tajika K, Gomi S, Omori I, Sato Y, Arai K, Kitano T, Mitamura Y, Kosaka F, Ryotokuji T, Hirakawa T, Wakita S, Inokuchi K, Dan K
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The clinical features and prognostic impact of de novo acute myeloid leukemia with RAS mutation2012
- Author(s)
  Sato Y, Yamaguchi H, Usuki K, Tajika K, Gomi S, Omori I, Todoroki T, Arai K, Kitano T, Mitamura Y, Kosaka F, Ryotokuji T, Hirakawa T, Wakita S, Inokuchi K, Dan K.
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] 本邦の骨髄不全症におけるSBDS遺伝子異常の検索2008
- Author(s)
  山口博樹, 竹内純子, 玉井勇人, 三田村佳勇, 小坂文子, 長谷川節雄, 檀和夫, 猪口孝一
- Organizer
  第70回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19591141
[Presentation] The prognostic impact of cytogenetic and genetic abnormality for the achievement of the second complete remission in adult patients with acute myeloid leukemia
- Author(s)
  Keiko Fukunaga, Hiroki Yamaguchi, Satoshi Wakita, Ikuko Omori, Shunsuke Yui, Takeshi Ryotokuji, Tsuneaki Hirakawa, Kunihito Arai, Tomoaki Kitano, Fumiko Kosaka, Kazuo Dan, Koiti Inokuchi
- Organizer
  The 6th JSH International Symposium
- Place of Presentation
  浜松
- Year and Date
  2014-05-23 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The prognostic impact of cytogenetic and genetic abnormality for the achievement of the second complete remission in adult patients with acute myeloid leukemia after first relapse
- Author(s)
  Keiko Fukunaga, Hiroki Yamaguchi, Satoshi Wakita, Ikuko Omori, Shunsuke Yui, Takeshi Ryotokuji, Tsuneaki Hirakawa, Kunihito Arai, Tomoaki Kitano, Fumiko Kosaka, Kazuo Dan, Koiti Inokuchi.
- Organizer
  19th. European Hematology Association
- Place of Presentation
  Milan, Italy
- Year and Date
  2014-06-12 – 2014-06-15
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] Decision Analysis of Allogeneic Hematopoietic Stem Cell Transplantation Versus Chemotherapy in Cytogenetically Standard-Risk Acute Myeloid Leukemia in First Complete Remission: The Impact of FLT3-ITD Profile
- Author(s)
  Saiko Kurosawa, Hiroki Yamaguchi, et al.
- Organizer
  56rd American Society of Hematology
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-12-06 – 2014-12-08
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] 移植適応を決定するうえでの遺伝子変異解析の重要性.
- Author(s)
  脇田知志、山口博樹、了徳寺剛、平川経晃、北野智章、荒井邦仁、小坂文子、猪口孝一.
- Organizer
  第36回日本造血細胞移植学会総会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The clinical features and prognostic impact of de novo acute myeloid leukemia with WT1mutation
- Author(s)
  Makoto Watanabe, Hiroki Yamaguchi, Kensuke Usuki, Yutaka Kobayashi, Kenji Tajika, Seiji Gomi, Anna Kobayashi, Kentaro Azuma, Yuko Sato, Takahiro Todoroki, Ikuko Omori, Fukunaga Keiko, Satoshi Wakita, Tsuneaki Hirakawa, Takeshi Ryotokuji, Kunihito Arai, Tomoaki Kitano, Fumiko Kosaka, Hayato Tamai, Koiti Inokuchi
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The prognostic impact of cytogenetic and genetic abnormality for the achievement of the second complete remission in adult patients with acute myeloid leukemia
- Author(s)
  Keiko Fukunaga, Hiroki Yamaguchi, Satoshi Wakita, Ikuko Omori, Shunsuke Yui, Takeshi Ryotokuji, Tsuneaki Hirakawa, Kunihito Arai, Tomoaki Kitano, Fumiko Kosaka, Koiti Inokuchi
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] 再発急性骨髄性白血病の第2寛解率に影響を与える染色体異常や遺伝子変異の探索.
- Author(s)
  福永景子、山口博樹、了徳寺剛、平川経晃、脇田知志、荒井邦仁、北野智章、小坂文子、玉井勇人、中山一隆、猪口孝一.
- Organizer
  第36回日本造血細胞移植学会総会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The clinical features and prognostic impact of acute myeloid leukemia with Epigenetics Modifying Gene mutation
- Author(s)
  Anna Kobayashi, Hiroki Yamaguchi, Kensuke Usuki, Yutaka Kobayashi, Kenji Tajika, Gomi Seiji, Makoto Watanabe, Kentaro Azuma, Yuko Sato, Takahiro Todoroki, Ikuko Omori, Fukunaga Keiko, Satoshi Wakita, Tsuneaki Hirakawa, Takeshi Ryotokuji, Kunihito Arai, Tomoaki Kitano1, Fumiko Kosaka, Hayato Tamai, Koiti Inokuchi
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The clinical features of PTPN11 gene mutation in Japanese patients with de novo AML
- Author(s)
  Shunsuke Yui, Hiroki Yamaguchi, et al
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The clinical feature and prognostic impact of de novo acute myeloid leukemia with Runx1 mutation.
- Author(s)
  Azuma K, Yamaguchi H, Usuki K, Kobayashi Y, Tajika K, Gomi S, Sato Y, Todoroki T, Omori I, Fukunaga K, Wakita S, Hirakawa T, Ryotokuji T, Arai K, Kitano T, Kosaka F, Dan K, Inokuchi K.
- Organizer
  第75回日本血液学会.
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The prognostic impact of complex gene mutation in the intermediate risk karyotype AML.
- Author(s)
  Wakita S, Yamaguchi H, Usuki K, Kobayashi Y, Gomi S, Tajika K, Hirakawa T, Ryotokuji T, Azuma K, Sato Y, Todoroki T, Omori I, Fukunaga K, Arai K, Kitano T, Kosaka F, Dan K, Inokuchi K.
- Organizer
  第75回日本血液学会.
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] THE DIFFERENCE OF RCSD1-ABL1- LEUKEMOGENICITY BETWEEN EXON3 OF RCSD1/EXON 4 OF ABL1 AND EXON 2 OF RCSD1/EXON 4 OF ABL1
- Author(s)
  Hayato Tamai , Koichi Miyake, Hiroki Yamaguchi, Kazuo Dan, Koiti Inokuchi
- Organizer
  19th. European Hematology Association
- Place of Presentation
  Milan, Italy
- Year and Date
  2014-06-12 – 2014-06-15
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The Prognostic Impact Of Complex Gene Mutation In The Intermediate Risk Karyotype Acute Myeloid Leukemia.
- Author(s)
  Satoshi Wakita, Hiroki Yamaguchi, Takeshi Ryotokuji, Tuneaki Hirakawa, Ikuko Omori, Tomoaki Kitano, Kunihito Arai, Yoshio Mitamura, Fumiko Kosaka, Kazuo Dan, and Koiti Inokuchi.
- Organizer
  55rd American Society of Hematology
- Place of Presentation
  New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] Comprehensive gene mutation analyses in acute myeloid leukemia: overlap of the gene mutations are important for the prognosis of the intermediate risk karyotype group.
- Author(s)
  Wakita S, Yamaguchi H, Ryotokuji T, Hirakawa T, Omori I, Kitano T, Arai K, Kosaka F, Dan K, Inokuchi K.
- Organizer
  18th. European Hematology Association.
- Place of Presentation
  Stockholm, Sweden
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The D816V c-kit mutation confers higher proliferation activity by JAK-STAT and Src family kinase pathways compared to N822K c-kit mutation in core-binding factor acute myeloid leukemia
- Author(s)
  Ikuko Omori, Hiroki Yamaguchi, Tomoaki Kitano, Noriko Miyake, Koichi Miyake, Koiti Inokuchi
- Organizer
  56rd American Society of Hematology
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-12-06 – 2014-12-08
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The prognostic and clinical feature of HSCT patients with chemotherapy refractory acute myeloid leukemia
- Author(s)
  Keiko Fukunaga, Hiroki Yamaguchi, Yusuke Fujiwara, Shunsuke Yui, Takeshi Ryotokuji, Tsuneaki Hirakawa, Masahiro Okabe, Satoshi Wakita, Hayato Tamai, Muneo Okamoto, Kazutaka Nakayama, Koiti Inokuchi
- Organizer
  第37回日本造血細胞移植学会総会
- Place of Presentation
  神戸
- Year and Date
  2015-03-05 – 2015-03-07
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] エピジェネティクス制御遺伝子変異は急性骨髄性白血病の多様な遺伝子変異の出現に寄与する.
- Author(s)
  脇田知志, 山口博樹, 了徳寺剛, 平川経晃, 大森郁子, 北野智章, 荒井邦仁, 三田村佳勇, 小坂文子, 檀　和夫, 猪口孝一.
- Organizer
  第109回日本内科学会総会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24591412
[Presentation] The prognostic impact of additional gene mutations among intermediate risk AML with CEBPA and NPM1.
- Author(s)
  Fukunaga K, Yamaguchi H, Wakita S, Usuki K, Kobayashi Y, Gomi S, Tajika K, Ryotokuji T, Hirakawa T, Azuma K, Sato Y, Todoroki T, Omori I, Arai K, Kitano T, Kosaka F, Dan K, Inokuchi K.
- Organizer
  第75回日本血液学会.
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24591412

1. Inokuchi Koiti (10203267)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. Shimoyama Takashi (00509325)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 木村和美 (00388927)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 鎌谷洋一郎 (00720880)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 松田浩一 (90401257)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. 中嶋亘 (40557500)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 脇田知志 (70465350)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 三宅弘一 (90267211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 青木淳哉 (00454819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 関根鉄朗 (00747826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 永田安伸 (90739575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Terada Kazuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. KAWAMURA Machiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 林泰秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 三宅紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 久保田寧

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 小川誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 江藤浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaguchi Hiroki 山口 博樹

YAMAGUCHI Hiroki 山口 博樹

山口 博樹 ヤマグチ ヒロキ

Research Projects

Research Products

Co-Researchers

脳卒中のAI画像解析とポリジェニックモデルによる関連遺伝子座の相関性分析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

BCL-2阻害剤抵抗性白血病における抗アポトーシス分子スイッチングの機序解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clinical significance and development of new target treatment of activated mitochondrial function in acute myeloid leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DNMT3A変異陽性AMLに生じるG2/M期の遺伝子発現異常とその標的治療の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Association between genetic risk for stroke and clinical characteristics in Japanese stroke patients

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The analysis of gene mutation acquisition and chemotherapy resistant mechanism by Hippo pathway of leukemia stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The identification of the novel gene mutation and development of the novel therapy for dyskeratosis congenitaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The pathogenesis of acute myeloid leukemia due to the CAP1 gene mutation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of pathogenesis mechanism and development of new treatment in bone marrow failure due to mutation of telomere regulated genes.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

骨髄不応性疾患におけるテロメラーゼ複合体遺伝子群の塩基配列変異の関連性についてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Annual Review 血液 2006(テロメラーゼ複合体遺伝子異常と骨髄不全症)2006

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Significance of FLT3-tyrosine kinase domain mutation as a prognostic factor for acute myeloid leukemia.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fatal Acute Exacerbation of Familial Interstitial Pneumonia Complicated with Dyskeratosis Congenita after Influenza Virus B Infection.2019

Author(s)

Journal Title

NAID

Yamaguchi Hiroki 山口博樹

YAMAGUCHI Hiroki 山口博樹

山口博樹ヤマグチヒロキ