Ayabe Tokiyoshi 綾部時芳

… Alternative Names

綾部時芳アヤベトキヨシ

AYABE Tokiyoshi 綾部時芳

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Researcher Number	90301019
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2023: 北海道大学, 先端生命科学研究院, 名誉教授 2018 – 2022: 北海道大学, 先端生命科学研究院, 教授 2012 – 2013: 北海道大学, 先端生命科学研究科(研究院), 教授 2011: 北海道大学, 大学院・先端生命科学研究院, 教授 2007 – 2008: Hokkaido University, 大学院・先端生命科学研究院, 教授 … More 2006: 北海道大学, 大学院先端生命科学研究院, 教授 2006: Asahikawa Medical college, Medicine, Assistant Professor 2004 – 2005: Asahikawa Medical College, Department of Gastrointestinal Immunologu and Regenerative Medicine, Associate Professor, 医学部, 寄附講座教員 2004: 旭川医科大学, 医学部, 講師 2001 – 2003: ASAHIKAWA MEDICAL COLLEGE, SCHOOL OF MEDICINE, INSTRUCTOR, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Basic Section 53020:Cardiology-related / Gastroenterology
Keywords	Principal Investigator 自然免疫 / パネート細胞 / Paneth細胞 / 炎症性腸疾患 / 腸内細菌 / 内因性抗菌ペプチド / 抗菌ペプチド / クローン病 / αディフェンシン / デフェンシン … More / 粘膜免疫 / 小胞体ストレス / 腸内環境 / αデイフェンシン / ディフェンシン / 消化管 / defensin / 腸内エコシステム / 腸内細菌叢 / α-defensin / mucosal immunity / host defense / Paneth cells / defensins / antimicrobial peptides / innate immunity / 小腸 / 腸管上皮細胞 / 生体防御 / 潰瘍性大腸炎 / 感染防御 / 非常在菌 / 常在菌 / 殺菌活性 / パネト細胞 / 樹状細胞 / 化学遊走能 / 炎症性サイトカイン / 炎症 / 微生物 / 微生物認識 / 感染症 / 獲得免疫 / ケモタキシス / Toll様受容体 / Toll-like receptor / シグナル伝達 … More Except Principal Investigator 抗菌ペプチド / 炎症性腸疾患 / 内因性抗菌ペプチド / 自然免疫 / defensin / 粘膜免疫 / ディフェンシン / 小腸パネート細胞 / 腸内フローラ / 心不全 / 小腸 / 腸内細菌 / αディフェンシン / Himan defensin 5 / Alpha-defensins / Crohn's disease / Innate immunity / Antibacterial peptides / Inflammatory Bowel Disease / 病原体認識 / デフェンシン / 潰瘍性大腸炎 / Human defensin 5 / alpha-defensin / クローン病 / INFLAMMATORY BOWEL DISEASE / PANETH CELL / a-DEFENSIN / ANTIMICROBIAL PEPTIDE / INTERNATIONAL SCIENCE EXCHANGE / innate immunity / IL-18R / NRAMP / paneth cell defensin / 粘膜防御 / Paneth細胞 / a-defensin / 国際学術交流 / 消化管 / 生体防御 / 腸上皮細胞 / パネート細胞 Less

Pathogenesis elucidation and treatment development for inflammatory bowel disease from a perspective of the gut ecosystem regulation by alpha-defensinPrincipal Investigator
- Principal Investigator
  
  Ayabe Tokiyoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hokkaido University
Role of alpha-defensins derived from the small intestine and gut microbiota in heart failure
- Principal Investigator
  
  Yokota Takashi
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hokkaido University
Regulation of intestinal environment by Paneth cells and new therapeutic strategy for inflammatory bowel diseasePrincipal Investigator
- Principal Investigator
  
  Ayabe Tokiyoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hokkaido University
腸における感覚の受容と制御の解明が拓く脳腸相関の新展開Principal Investigator
- Principal Investigator
  
  綾部時芳
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
αディフェンシンによる腸内細菌の統御機構からみた炎症性腸疾患の病因解明と新規治療Principal Investigator
- Principal Investigator
  
  綾部時芳
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
腸内細菌の病原性・非病原性と抗菌ペプチドの作用機構の解明Principal Investigator
- Principal Investigator
  
  綾部時芳
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Regulation of intestinal inflammation by Paneth cell α-defensinPrincipal Investigator
- Principal Investigator
  
  AYABE Tokiyoshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
ヒト腸上皮の微生物認識機構と内因性抗菌ペプチドによる殺菌機能の分子基盤Principal Investigator
- Principal Investigator
  
  綾部時芳
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Asahikawa Medical College
微生物感染を契機とするヒト腸管粘膜における自然免疫と獲得免疫間クロストークPrincipal Investigator
- Principal Investigator
  
  綾部時芳
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Asahikawa Medical College
The role of innate immunity in inflammatory bowel disease
- Principal Investigator
  
  KOHGO Yutaka
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
Functional analysis of defensins in human innate intestinall immunity.Principal Investigator
- Principal Investigator
  
  AYABE Tokiyoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
単離細胞を用いたヒト消化管自然免疫機能に関わる分子基盤の解析Principal Investigator
- Principal Investigator
  
  綾部時芳
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Asahikawa Medical College
ヒト消化管パネート細胞と微生物との相互作用の自然免疫分子基盤の解明Principal Investigator
- Principal Investigator
  
  綾部時芳
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Asahikawa Medical College
新たな消化管抗菌ペプチドdefensin subfamilyの同定
- Principal Investigator
  
  高後裕
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
INTRINSIC ANTIMICROBIAL POLYPEPTIDE IN INFLAMMATROY BOWEL DISEASE
- Principal Investigator
  
  KOHGO Yutaka
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  ASAHIKAWA MEDICAL COLLEGE

[Book] プレコンセプションケア2024
- Author(s)
  綾部時芳
- Total Pages
  447
- Publisher
  株式会社メジカルビュー社
- ISBN
  9784758321402
- Data Source
  KAKENHI-PROJECT-21H02891
[Book] 腸内フローラとクロストーク2008
- Author(s)
  綾部時芳, 他
- Total Pages
  125
- Publisher
  学会出版センター
- Data Source
  KAKENHI-PROJECT-18390212
[Book] ヒトPaneth細胞分泌物による炎症反応の制御. 消化器と免疫452008
- Author(s)
  伊藤貴博, 綾部時芳, 上野伸展, 金野陽高, 石川千里, 盛一健太郎, 岡本耕太郎, 田邊裕貴, 前本篤男, 藤谷幹浩, 河野透, 蘆田知史, 高後裕, 吉川敏一
- Publisher
  日本消化器免疫学会
- Data Source
  KAKENHI-PROJECT-18390212
[Book] 腸内フローラとクロストーク2008
- Author(s)
  綾部時芳
- Publisher
  学会事務センター
- Data Source
  KAKENHI-PROJECT-18390212
[Book] 腸内フローラとクロストーク2008
- Author(s)
  綾部時芳, 他
- Total Pages
  125
- Publisher
  学会出版センター
- Data Source
  KAKENHI-PROJECT-19041005
[Book] 自然免疫vol.22005
- Author(s)
  綾部時芳
- Total Pages
  188
- Publisher
  Innate Immunity研究会出版
- Data Source
  KAKENHI-PROJECT-16017208
[Book] 自然免疫vol.12004
- Author(s)
  綾部時芳
- Total Pages
  211
- Publisher
  Innate immunity研究会
- Data Source
  KAKENHI-PROJECT-16017208
[Book] 自然免疫 vol.12004
- Author(s)
  綾部時芳
- Total Pages
  211
- Publisher
  Innate immunity研究会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590610
[Book] Annual Review免疫20052004
- Author(s)
  綾部時芳, 他
- Total Pages
  260
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-15390223
[Journal Article] Effects of exposure to the neonicotinoid pesticide clothianidin on α-defensin secretion and gut microbiota in mice2024
- Author(s)
  YONOICHI Sakura、HARA Yukako、ISHIDA Yuya、SHODA Asuka、KIMURA Mako、MURATA Midori、NUNOBIKI Sarika、ITO Makiko、YOSHIMOTO Ayano、MANTANI Youhei、YOKOYAMA Toshifumi、HIRANO Tetsushi、IKENAKA Yoshinori、YOKOI Yuki、AYABE Tokiyoshi、NAKAMURA Kiminori、HOSHI Nobuhiko
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 86 Issue: 3 Pages: 277-284
- DOI
  10.1292/jvms.23-0514
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19846, KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-23K25004
[Journal Article] Antimicrobial Properties and Mode of Action of Cryptdin-4, a Mouse α-Defensin Regulated by Peptide Redox Structures and Bacterial Cultivation Conditions2023
- Author(s)
  Wang Yi、Song Yuchi、Yan Shaonan、Hiramine Rina、Ohnishi Yuki、Yokoi Yuki、Nakamura Kiminori、Kikukawa Takashi、Ayabe Tokiyoshi、Aizawa Tomoyasu
- Journal Title
  
  Antibiotics
  
  Volume: 12 Issue: 6 Pages: 1047-1047
- DOI
  10.3390/antibiotics12061047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21H02891
[Journal Article] Associations between Maternal Diet, Human Milk Macronutrients, and Breast-Fed Infant Growth during the First Month of Life in the SMILE Iwamizawa in Japan2023
- Author(s)
  Komatsu Yosuke、Wada Yasuaki、Tabata Fuka、Kawakami Satomi、Takeda Yasuhiro、Nakamura Kiminori、Ayabe Tokiyoshi、Nakamura Koshi、Kimura Takashi、Tamakoshi Akiko
- Journal Title
  
  Nutrients
  
  Volume: 15 Issue: 3 Pages: 654-654
- DOI
  10.3390/nu15030654
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891
[Journal Article] A Basic Study of the Effects of Mulberry Leaf Administration to Healthy C57BL/6 Mice on Gut Microbiota and Metabolites2023
- Author(s)
  Gan Li、Inamura Yuga、Shimizu Yu、Yokoi Yuki、Ohnishi Yuki、Song Zihao、Kumaki Yasuhiro、Kikukawa Takashi、Demura Makoto、Ito Masaaki、Ayabe Tokiyoshi、Nakamura Kiminori、Aizawa Tomoyasu
- Journal Title
  
  Metabolites
  
  Volume: 13 Issue: 9 Pages: 1003-1003
- DOI
  10.3390/metabo13091003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K04849, KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21H02891
[Journal Article] Shorter sleep time relates to lower human defensin 5 secretion and compositional disturbance of the intestinal microbiota accompanied by decreased short-chain fatty acid production2023
- Author(s)
  Shimizu Yu、Yamamura Ryodai、Yokoi Yuki、Ayabe Tokiyoshi、Ukawa Shigekazu、Nakamura Koshi、Okada Emiko、Imae Akihiro、Nakagawa Takafumi、Tamakoshi Akiko、Nakamura Kiminori
- Journal Title
  
  Gut Microbes
  
  Volume: 15 Issue: 1 Pages: 2190306-2190306
- DOI
  10.1080/19490976.2023.2190306
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-22K16009, KAKENHI-PROJECT-21H02891
[Journal Article] 今だから聞きたい！ Q&A．抗菌ペプチドとは？2023
- Author(s)
  綾部時芳
- Journal Title
  
  Microbiome Science
  
  Volume: 2 Pages: 55-56
- Data Source
  KAKENHI-PROJECT-21H02891
[Journal Article] Application of Benchtop NMR for Metabolomics Study Using Feces of Mice with DSS-Induced Colitis2023
- Author(s)
  Song Zihao、Ohnishi Yuki、Osada Seiji、Gan Li、Jiang Jiaxi、Hu Zhiyan、Kumeta Hiroyuki、Kumaki Yasuhiro、Yokoi Yuki、Nakamura Kiminori、Ayabe Tokiyoshi、Yamauchi Kazuo、Aizawa Tomoyasu
- Journal Title
  
  Metabolites
  
  Volume: 13 Issue: 5 Pages: 611-611
- DOI
  10.3390/metabo13050611
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21H02891
[Journal Article] Efficient recombinant production of mouse-derived cryptdin family peptides by a novel facilitation strategy for inclusion body formation2023
- Author(s)
  Song Yuchi、Wang Yi、Yan Shaonan、Nakamura Kiminori、Kikukawa Takashi、Ayabe Tokiyoshi、Aizawa Tomoyasu
- Journal Title
  
  Microbial Cell Factories
  
  Volume: 22 Issue: 1 Pages: 9-9
- DOI
  10.1186/s12934-023-02016-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PUBLICLY-22H05389, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-23K23843
[Journal Article] Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota2023
- Author(s)
  Nakamura Shunta、Nakamura Kiminori、Yokoi Yuki、Shimizu Yu、Ohira Shuya、Hagiwara Mizu、Song Zihao、Gan Li、Aizawa Tomoyasu、Hashimoto Daigo、Teshima Takanori、Ouellette Andre J.、Ayabe Tokiyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 3953-3953
- DOI
  10.1038/s41598-023-30997-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08409, KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-22KJ0054, KAKENHI-PROJECT-20K21610, KAKENHI-PROJECT-22K16009, KAKENHI-PROJECT-23K21439
[Journal Article] Oral frailty and carriage of oral Candida in community‐dwelling older adults (Check‐up to discover Health with Energy for senior Residents in Iwamizawa; CHEER Iwamizawa)2022
- Author(s)
  Baba Haruhisa, Watanabe Yutaka, Miura Kazuhito, Ozaki Kimiya, Matsushita Takae, Kondoh Miyako, Okada Kazutaka, Hasebe Akira, Ayabe Tokiyoshi, Nakamura Kiminori, Nakaoka Shinji, Ogasawara Katsuhiko, Suzuki Teppei, Saito Hiroshi, Kimura Takashi, Tamakoshi Akiko, Yamazaki Yutaka
- Journal Title
  
  Gerodontology
  
  Volume: 39 Issue: 1 Pages: 49-58
- DOI
  10.1111/ger.12621
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09903, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-23K20331, KAKENHI-PROJECT-23K20334
[Journal Article] Efficient and simple genetic engineering of enteroids using mouse isolated crypts for investigating intestinal functions2022
- Author(s)
  Ohira Shuya、Yokoi Yuki、Ayabe Tokiyoshi、Nakamura Kiminori
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 637 Pages: 153-160
- DOI
  10.1016/j.bbrc.2022.11.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-22KJ0054
[Journal Article] Ingestion of miso regulates immunological robustness in mice2022
- Author(s)
  Kotake Kunihiko、Kumazawa Toshihiko、Nakamura Kiminori、Shimizu Yu、Ayabe Tokiyoshi、Adachi Takahiro
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 1 Pages: e0261680-e0261680
- DOI
  10.1371/journal.pone.0261680
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891
[Journal Article] Intestinal commensal microbiota and cytokines regulate Fut2 <sup>+</sup> Paneth cells for gut defense2022
- Author(s)
  Kamioka Mariko、Goto Yoshiyuki、Nakamura Kiminori、Yokoi Yuki、Sugimoto Rina、Ohira Shuya、Kurashima Yosuke、Umemoto Shingo、Sato Shintaro、Kunisawa Jun、Takahashi Yu、Domino Steven E.、Renauld Jean-Christophe、Nakae Susumu、Iwakura Yoichiro、Ernst Peter B.、Ayabe Tokiyoshi、Kiyono Hiroshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 3 Pages: 1-10
- DOI
  10.1073/pnas.2115230119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-21H02963, KAKENHI-PROJECT-20J11528, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21K19494, KAKENHI-PROJECT-19K17452, KAKENHI-PROJECT-18H05280
[Journal Article] Reactive granulopoiesis depends on T-cell production of IL-17A and neutropenia-associated alteration of gut microbiota2022
- Author(s)
  Chen Xuanzhong、Hashimoto Daigo、Ebata Ko、Takahashi Shuichiro、Shimizu Yu、Shinozaki Ryuga、Hasegawa Yuta、Kikuchi Ryo、Senjo Hajime、Yoneda Kazuki、Zhang Zixuan、Harada Shinpei、Hayase Eiko、Ara Takahide、Ohigashi Hiroyuki、Iwakura Yoichiro、Nakamura Kiminori、Ayabe Tokiyoshi、Teshima Takanori
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 48 Pages: 1-10
- DOI
  10.1073/pnas.2211230119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08409, KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K16259, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-22KJ0033, KAKENHI-PROJECT-20K21610, KAKENHI-PROJECT-22K16009, KAKENHI-PROJECT-23K21439
[Journal Article] Hemodynamic response to intestinal pH stimulation measured with spectroscopic video imaging2022
- Author(s)
  Funane Tsukasa、Yokoi Yuki、Kikuchi Masashi、Shinozaki Ryuga、Ayabe Tokiyoshi、Atsumori Hirokazu、Nishimura Ayako、Nakamura Kiminori、Kandori Akihiko
- Journal Title
  
  Biomedical Physics & Engineering Express
  
  Volume: 9 Issue: 1 Pages: 017001-017001
- DOI
  10.1088/2057-1976/aca20a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-22KJ0033
[Journal Article] Potent bactericidal activity of reduced cryptdin-4 derived from its hydrophobicity and mediated by bacterial membrane disruption2022
- Author(s)
  Sato Yuji、Wang Yi、Song Yuchi、Geng Weiming、Yan Shaonan、Nakamura Kiminori、Kikukawa Takashi、Demura Makoto、Ayabe Tokiyoshi、Aizawa Tomoyasu
- Journal Title
  
  Amino Acids
  
  Volume: 54 Issue: 2 Pages: 289-297
- DOI
  10.1007/s00726-021-03115-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891
[Journal Article] Simultaneous real-time analysis of Paneth cell and intestinal stem cell response to interferon-γ by a novel stem cell niche tracking method2021
- Author(s)
  Yokoi Y, Adachi T, Sugimoto R, Kikuchi M, Ayabe T, Nakamura K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 545 Pages: 14-19
- DOI
  10.1016/j.bbrc.2021.01.050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-19J11999, KAKENHI-PROJECT-20J11528
[Journal Article] Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model2021
- Author(s)
  Suzuki Kosuke、Nakamura Kiminori、Shimizu Yu、Yokoi Yuki、Ohira Shuya、Hagiwara Mizu、Wang Yi、Song Yuchi、Aizawa Tomoyasu、Ayabe Tokiyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 9915-9915
- DOI
  10.1038/s41598-021-89308-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-21K15460
[Journal Article] Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study2021
- Author(s)
  Shimizu Yu、Nakamura Kiminori、Kikuchi Mani、Ukawa Shigekazu、Nakamura Koshi、Okada Emiko、Imae Akihiro、Nakagawa Takafumi、Yamamura Ryodai、Tamakoshi Akiko、Ayabe Tokiyoshi
- Journal Title
  
  GeroScience
  
  Volume: - Issue: 2 Pages: 997-1009
- DOI
  10.1007/s11357-021-00398-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15463, KAKENHI-PROJECT-21H02891
[Journal Article] Disease progression-associated alterations in fecal metabololies in SAMP1/YitFc mice, a Crohn’s disease model2020
- Author(s)
  Komatsu Y, Shimizu Y, Yamano M, Kikuchi M, Nakamura K, Ayabe T, Aizawa T
- Journal Title
  
  Metabolomics
  
  Volume: 16 Issue: 4 Pages: 48-48
- DOI
  10.1007/s11306-020-01671-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-20H04098
[Journal Article] Mycotoxin deoxynivalenol has different impacts on intestinal barrier and stem cells by its route of exposure2020
- Author(s)
  Hanyu H, Yokoi Y, Nakamura K, Ayabe T, Tanaka K, Uno K, Miyajima K, Saito Y, Iwatsuki K, Shimizu M, Tadaishi M, Kobayashi-Hattori K
- Journal Title
  
  Toxins
  
  Volume: 12 Issue: 10 Pages: 610-610
- DOI
  10.3390/toxins12100610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-19J11999, KAKENHI-PROJECT-18K05480
[Journal Article] Expression and localization of Paneth cells and their alpha-defensins in the small intestine of adult mouse2020
- Author(s)
  Nakamura K, Yokoi Y, Fukaya R, Ohira S, Shinozaki R, Nishida T, Kikuchi M, Ayabe T
- Journal Title
  
  Front Immunol
  
  Volume: 11 Pages: 570296-570296
- DOI
  10.3389/fimmu.2020.570296
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-19J11999
[Journal Article] Analysis of Serotonin in Human Feces Using Solid Phase Extraction and Column-Switching LC-MS/MS2020
- Author(s)
  Hirabayashi Y, Nakamura K, Sonehara T, Suzuki D, Hanzawa S, Shimizu Y, Aizawa T, Nakamura K, Tamakoshi A, Ayabe T
- Journal Title
  
  Mass Spectrometry
  
  Volume: 9 Issue: 1 Pages: A0081-A0081
- DOI
  10.5702/massspectrometry.A0081
- NAID
  130007823248
- ISSN
  2186-5116, 2187-137X
- Year and Date
  2020-03-31
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-17K11661, KAKENHI-PROJECT-20H04098
[Journal Article] Paneth cell alpha-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice2020
- Author(s)
  Shimizu Y, Nakamura K, Yoshii A, Yokoi Y, Kikuchi M, Shinozaki R, Nakamura S, Ohira S, Sugimoto R, Ayabe T
- Journal Title
  
  Life Science Alliance
  
  Volume: 3 Issue: 6 Pages: e201900592-e201900592
- DOI
  10.26508/lsa.201900592
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-19J11999, KAKENHI-PROJECT-20J11528
[Journal Article] Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids2020
- Author(s)
  Yamamura R, Nakamura K, Kitada N, Aizawa T, Shimizu Y, Nakamura K, Ayabe T, Kimura T, Tamakoshi A
- Journal Title
  
  Bioscience of Microbiota, Food and Health
  
  Volume: 39 Issue: 1 Pages: 11-17
- DOI
  10.12938/bmfh.19-010
- NAID
  130007788976
- ISSN
  2186-3342
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-17K11661, KAKENHI-PROJECT-20H04098
[Journal Article] Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids2019
- Author(s)
  Yokoi Yuki、Nakamura Kiminori、Yoneda Tsukasa、Kikuchi Mani、Sugimoto Rina、Shimizu Yu、Ayabe Tokiyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41598-019-39610-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788
[Journal Article] Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway.2019
- Author(s)
  Pillai MR, Mihi B, Ishiwata K, Nakamura K, Sakuragi N, Finkelstein DB, McGargill MA, Nakayama T, Ayabe T, Coleman ML, Bix M
- Journal Title
  
  PLoS One
  
  Volume: 26;14(2):e0211244 Issue: 2 Pages: 1-21
- DOI
  10.1371/journal.pone.0211244
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11661, KAKENHI-PROJECT-18H02788
[Journal Article] A simple culture method for liver and intestinal tissue-resident macrophages from neonatal mice2019
- Author(s)
  Shimizu Y, Sakuragi N, Nakamura K, Taira T, Ayabe T, Fukui A
- Journal Title
  
  In Vitro Cell Dev Biol - Animal
  
  Volume: 55 Issue: 6 Pages: 436-444
- DOI
  10.1007/s11626-019-00359-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-17K11661
[Journal Article] Butyric Acid and Leucine Induce α-Defensin Secretion from Small Intestinal Paneth Cells2019
- Author(s)
  Takakuwa Akiko、Nakamura Kiminori、Kikuchi Mani、Sugimoto Rina、Ohira Shuya、Yokoi Yuki、Ayabe Tokiyoshi
- Journal Title
  
  Nutrients
  
  Volume: 11 Issue: 11 Pages: 2817-2817
- DOI
  10.3390/nu11112817
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17931, KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-19J11999, KAKENHI-PROJECT-17K11661
[Journal Article] Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency2018
- Author(s)
  Cobo Eduardo R.、Holani Ravi、Moreau France、Nakamura Kiminori、Ayabe Tokiyoshi、Mastroianni Jennifer R.、Ouellette Andre、Chadee Kris
- Journal Title
  
  Infection and Immunity
  
  Volume: 86 Issue: 7
- DOI
  10.1128/iai.00208-18
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02788
[Journal Article] Essential role of IFN-γ in T cell?associated intestinal inflammation2018
- Author(s)
  Eriguchi Yoshihiro、Nakamura Kiminori、Yokoi Yuki、Sugimoto Rina、Takahashi Shuichiro、Hashimoto Daigo、Teshima Takanori、Ayabe Tokiyoshi、Selsted Michael E.、Ouellette Andre J.
- Journal Title
  
  JCI Insight
  
  Volume: 3 Issue: 18 Pages: 1-18
- DOI
  10.1172/jci.insight.121886
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09945, KAKENHI-PROJECT-17K11661, KAKENHI-PROJECT-17H04206, KAKENHI-PROJECT-18H02788
[Journal Article] Ploidy-dependent change in cyclin D2 expression and sensitization to cdk4/6 inhibition in human somatic haploid cells.2018
- Author(s)
  Yaguchi K, Yamamoto T, Shimada M, Sugimoto R, Nakamura K, Ayabe T, Uehara R.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 504 Issue: 1 Pages: 231-231
- DOI
  10.1016/j.bbrc.2018.08.160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11661, KAKENHI-PROJECT-18H02788, KAKENHI-PROJECT-17K15111
[Journal Article] Graft-versus-host disease disrup ts intestinal microbial ecology by i nhibiting Paneth cell production of α-defensins2012
- Author(s)
  Eriguchi Y, Takashima S 他10名
- Journal Title
  
  Blood
  
  Volume: 120巻 Issue: 1 Pages: 223-231
- DOI
  10.1182/blood-2011-12-401166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390295, KAKENHI-PROJECT-22592029, KAKENHI-PROJECT-23390193, KAKENHI-PROJECT-23659490, KAKENHI-PROJECT-24790977
[Journal Article] Paneth cells and stem cells in tne intestinal stem cell niche and their association with inflammatory bowel disease2012
- Author(s)
  Nakamura K, Ayabe T
- Journal Title
  
  Inflammation Regeneration
  
  Volume: 32 Pages: 53-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390193
[Journal Article] Paneth Cells Regulate Both Chemotaxis of Immature Dendritic Cells and Cytokine Production from Epithelial Cells2012
- Author(s)
  Ito T, Ayabe T, Ishikawa C, Inaba Y, Tanabe H, Maemoto A, Kono T, Ashida T, Fujiya M, Kohgo Y.
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 227 Issue: 1 Pages: 39-48
- DOI
  10.1620/tjem.227.39
- NAID
  130004459980
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390148, KAKENHI-PROJECT-23390193, KAKENHI-PROJECT-23590931
[Journal Article] Regulation of microbiota by antimicrobial peptides in the gut2011
- Author(s)
  Masuda K, Nakamura K, Yoshioka S, Fukaya R, Sakai N, Ayabe T
- Journal Title
  
  Adv Otorhinolaryngol
  
  Volume: 72 Pages: 97-99
- DOI
  10.1159/000324625
- ISBN
  9783805597227, 9783805597234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592029, KAKENHI-PROJECT-23390193
[Journal Article] Bactericidal activity of mouse α-defensin cryptdin-4 predominantly affects noncommensal bacteria2011
- Author(s)
  Masuda K, Sakai N, Nakamura K, Yoshioka S, Ayabe T
- Journal Title
  
  J Innate Immun
  
  Volume: 3 Issue: 3 Pages: 315-326
- DOI
  10.1159/000322037
- NAID
  120002989233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592029, KAKENHI-PROJECT-23390193
[Journal Article] A systematic analysis of aromatic heterocyclic rings in solvatochromic fluorophores.2011
- Author(s)
  Son SH., Abe Y., Yuasa M., Yamagishi Y., Sakai N., Ayabe
- Journal Title
  
  Chem Lett
  
  Volume: 40 Issue: 4 Pages: 378-380
- DOI
  10.1246/cl.2011.378
- NAID
  10028170581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390193
[Journal Article] Functional role of metaplastic Paneth cell defensins in Helicobacter pylori-infected stomach2008
- Author(s)
  Tanabe H, Sato T, Watari J, Maemoto A, Fujiya M, Kono T, Ashida T, Ayabe T and Kohgo Y
- Journal Title
  
  Helicobacter 13
  
  Pages: 370-379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390212
[Journal Article] 腸管再生・分化の制御機構と再生医療細胞工学2008
- Author(s)
  綾部時芳
- Journal Title
  
  特集 : 消化管研究の最前線. 細胞工学 27
  
  Pages: 796-799
- Data Source
  KAKENHI-PROJECT-18390212
[Journal Article] 自然免疫異常による生体防御破綻2008
- Author(s)
  綾部時芳
- Journal Title
  
  特集 : 炎症性腸疾患の分子医学. BIO Clinica 23
  
  Pages: 1178-1182
- Data Source
  KAKENHI-PROJECT-18390212
[Journal Article] Antimicrobial peptides in the gut innate immunity2008
- Author(s)
  Sakai N and Ayabe T.
- Journal Title
  
  Int J Probiotics Prebiotics 3
  
  Pages: 123-126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390212
[Journal Article] Denatured human α-defensin attenuates the bactericidal activity and the stability against enzymatic digestion2007
- Author(s)
  Tanabe H, Ayabe T, Maemoto A, Ishikawa C, Inaba Y, Sato R, Moriichi K, Okamoto K, Watari J, Kono T, Ashida T, Kohgo Y
- Journal Title
  
  Biochm Biophys Res Commun 358
  
  Pages: 349-355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390212
[Journal Article] クローン病におけるPaneth細胞由来抗菌ペプチドの産生異常2007
- Author(s)
  田邊裕貴、前本篤男、綾部時芳、河野透、蘆田知史、高後裕
- Journal Title
  
  分子消化器病 4
  
  Pages: 110-115
- Data Source
  KAKENHI-PROJECT-18390212
[Journal Article] Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion.2007
- Author(s)
  Tanabe H, Ayabe T, Kohgo Y, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 358(1)
  
  Pages: 349-55
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390223
[Journal Article] 腸上皮細胞のpattern recognition receptorとその解析法2007
- Author(s)
  綾部時芳
- Journal Title
  
  分子消化器病 4
  
  Pages: 53-56
- Data Source
  KAKENHI-PROJECT-18390212
[Journal Article] 腸上皮細胞のpattern recognition receptorとその解析法2007
- Author(s)
  綾部時芳
- Journal Title
  
  分子消化器病 4・1
  
  Pages: 53-56
- Data Source
  KAKENHI-PROJECT-18390212
[Journal Article] Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion.2007
- Author(s)
  Tanabe H, Ayabe T, KohgoY, et al.
- Journal Title
  
  Biochem Biophys Res Commun 358(1)
  
  Pages: 349-55
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390223
[Journal Article] Denatured human α-defensin attenuates the bactericidal activity and the stability against enzymatic digestion.2007
- Author(s)
  Tanabe H, Ayabe T, Maemoto A, Ishikawa C, Inaba Y, Sato R, Moriichi K, Okamoto K, Watari J, Kono T, Ashida T, Kohgo Y
- Journal Title
  
  Biochm Biophys Res Commun 358
  
  Pages: 349-355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041005
[Journal Article] Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion2007
- Author(s)
  Tanabe H, Ayabe T, Maemoto A, Ishikawa C, Inaba Y, Sato R, Moriichi K, Okamoto K, Watari J, Kono T, Ashida T, Kohgo Y
- Journal Title
  
  Biochm Biophys Res Commun 358
  
  Pages: 349-355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390212
[Journal Article] Mouse Paneth cell responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria.2005
- Author(s)
  Tanabe H, Ayabe T et al.
- Journal Title
  
  Infect Immun 73
  
  Pages: 2312-2320
- Data Source
  KAKENHI-PROJECT-16017208
[Journal Article] Innate immunity and Macrophage/antigen presenting cell. Innate immunity and antigen presentation in intestinal epithelia.2005
- Author(s)
  Ayabe T, Kohgo Y.
- Journal Title
  
  Annual Review (Immunology) vol. 2005
  
  Pages: 81-87
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390223
[Journal Article] 自然免疫, マクロファージ・抗原提示細胞腸粘膜上皮におけるPaneth細胞の自然免疫機能と病原体認識機構.2004
- Author(s)
  綾部時芳, 高後裕, 他
- Journal Title
  
  Annual Review免疫 2005巻
  
  Pages: 81-87
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390223
[Journal Article] The role of Paneth cells and their antimicrobial peptides in innate host defense.2004
- Author(s)
  Ayabe T et al.
- Journal Title
  
  Trends Microbiol 12
  
  Pages: 394-398
- Data Source
  KAKENHI-PROJECT-16017208
[Journal Article] The role of Paneth cells and their antimicrobial peptides in innate host defense.2004
- Author(s)
  Ayabe T et al.
- Journal Title
  
  Trends Microbiol 12
  
  Pages: 394-398
- Data Source
  KAKENHI-PROJECT-15390223
[Journal Article] The role of Paneth cells and their antimicrobial peptides in innate host defence.2004
- Author(s)
  AyabeT, Kohgo Y, et al.
- Journal Title
  
  Trends Microbiol 12
  
  Pages: 394-398
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390223
[Journal Article] The role of Paneth cells and their antimicrobial peptides in innate host defense.2004
- Author(s)
  Ayabe T et al.
- Journal Title
  
  Trends Microbiol 12
  
  Pages: 394-398
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590610
[Journal Article] The role of Paneth cells and their antimicrobial peptides in innate host defence.2004
- Author(s)
  Ayabe T, Kohgo Y, et al.
- Journal Title
  
  Trends Microbiol 12
  
  Pages: 394-398
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390223
[Presentation] Selective Paneth cell granule secretion in response to pathogenic and commensal bacteria in enteric mucosal immunity2024
- Author(s)
  Yuki Yokoi, Shuya Ohira, Haruto Matsuoka, Shota Takemi, Tokiyoshi Ayabe, Kiminori Nakamura
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] Paneth細胞が担う免疫/共生の異常による腸内細菌叢の撹乱を介する疾患発症2024
- Author(s)
  綾部時芳
- Organizer
  GI Week2024 第51回日本潰瘍学会（シンポジウム）
- Invited
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] 短眠はPaneth細胞α-defensin分泌量の低値および短鎖脂肪酸の産生量低下を伴う腸内細菌叢組成の撹乱に関係する2023
- Author(s)
  清水由宇、山村凌大、横井友樹、綾部時芳、鵜川重和、中村幸志、岡田恵美子、今江章宏、中川貴史、玉腰暁子、中村公則
- Organizer
  第27回腸内細菌学会学術集会（ワークショップ）
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] 共生メカニズムからみた腸内細菌と疾患2023
- Author(s)
  綾部時芳
- Organizer
  本消化器病学会北海道支部　第25回教育講演会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] Application of a bench-top NMR instrument for omics studies of gut microbiota metabolites2022
- Author(s)
  Zihao Song, Yuki Ohnishi, Seiji Osada, Li Gan, Jiaxi Jiang, Zhiyan Hu, Hiroyuki Kumeta, Yasuhiro Kumaki, Kiminori Nakamura, Tokiyoshi Ayabe, Kazuo Yamauchi, Tomoyasu Aizawa
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] αディフェンシンが担う腸内細菌叢制御と予防医療2022
- Author(s)
  綾部時芳
- Organizer
  第62回自然免疫賦活技術研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] 抗菌ペプチドαディフェンシンによる腸内細菌制御と健康2022
- Author(s)
  綾部時芳、横井友樹、清水由宇、中村公則
- Organizer
  日本食品・機械研究会第17回腸内細菌をターゲットとした食品開発研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] 食品が誘導するPaneth細胞αディフェンシンによる免疫と共生2022
- Author(s)
  綾部時芳、横井友樹、高桑暁子、中村公則
- Organizer
  第18回日本食品免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] 高齢者におけるPaneth細胞α-defensin分泌量の低さは加齢に伴う腸内細菌叢の遷移に関連する2022
- Author(s)
  清水由宇、中村公則、菊池摩仁、鵜川重和、中村幸志、岡田恵美子、今江章宏、中川貴史、山村凌大、玉腰暁子、綾部時芳
- Organizer
  第26回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] High-efficient genetic engineering of enteroids using mouse isolated crypts revealing the intestinal function2022
- Author(s)
  Shuya Ohira, Yuki Yokoi, Yuito Kaibori, Yu Shimizu, Tokiyoshi Ayabe, Kiminori Nakamura
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] 腸内細菌との共生～その破綻による疾患2022
- Author(s)
  綾部時芳
- Organizer
  腸内フローラを考える会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] Regulation of Paneth cell granule secretion by selective sensing of pathogenic and commensal bacteria in intestinal homeostasis2022
- Author(s)
  Yuki Yokoi, Shuya Ohira, Haruto Matsuoka, Yuito Kaibori, Ryuga Shinozaki, Tokiyoshi Ayabe, Kiminori Nakamura
- Organizer
  第45回日本分子生物学会年会　ワークショップ
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] ベンチトップ NMR による炎症性腸疾患モデルマウスのメタボロミクス研究2022
- Author(s)
  宋子豪、大西裕季、長田誠司、甘莉、蒋佳稀、胡知彦、久米田博之、熊木康裕、中村公則、綾部時芳、山内一夫、相沢智康
- Organizer
  第61回NMR討論会
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] 霊長類T1R1およびT1R2抗体の作製2021
- Author(s)
  小松さゆり、中安亜希、大島永心、新藤壮剛、今井啓雄、伯川美穂、杉山宗太郎、綾部時芳、中村公則、山根拓実、大石祐一、岩槻健
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] ER Stress-Associated Misfolding of Paneth Cell α-Defensin Induces Dysbiosis and Ileitis in a Murine Model of Crohn’s Disease2021
- Author(s)
  Yu Shimizu, Kiminori Nakamura, Aki Yoshii, Yuki Yokoi, Mani Kikuchi, Ryuga Shinozaki, Shunta Nakamura, Shuya Ohira, Rina Sugimoto, Tokiyoshi Ayabe
- Organizer
  World Microbe Forum. Host-Microbe Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] 母親の高脂肪食摂取が子のPaneth細胞の発達に与える作用メカニズム2021
- Author(s)
  八塚夏美、杉本理菜、大平修也、横井友樹、菊池摩仁、綾部時芳、中村公則
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] 抗菌ペプチドから粘膜免疫を理解する2021
- Author(s)
  綾部時芳、横井友樹、中村公則
- Organizer
  第58回日本消化器免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] Paneth細胞顆粒分泌応答からみた食機能評価系の確立2021
- Author(s)
  横井友樹、中村公則、高桑暁子、菊池摩仁、綾部時芳
- Organizer
  第17回日本食品免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] Dynamics of Paneth cell granule secretory responses to bacteria in innate enteric immunity2021
- Author(s)
  Yuki Yokoi, Kiminori Nakamura, Shuya Ohira, Ryuga Shinozaki, Mani Kikuchi, Tokiyoshi Ayabe.
- Organizer
  World Microbe Forum. Host-Microbe Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] 食を介したPaneth細胞の機能異常に基づくNASH発症メカニズムの解明2021
- Author(s)
  萩原瑞、中村公則、中村駿太、八塚夏美、杉本理菜、横井友樹、綾部時芳
- Organizer
  令和2年度北大細胞生物研究集会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Simple and efficient genetic engineering of enteroids by using mouse isolated crypts2021
- Author(s)
  Shuya Ohira, Yuki Yokoi, Mani Kikuchi, Natsumi Yatsuzuka, Tokiyoshi Ayabe, Kiminori Nakamura
- Organizer
  第44回日本分子生物学会年会ワークショップ
- Data Source
  KAKENHI-PROJECT-21H02891
[Presentation] 腸内細菌はなぜ大切か？　自然免疫と腸内細菌から病気を紐解く2020
- Author(s)
  綾部時芳
- Organizer
  第45回札幌市医師会医学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] 桑葉摂取によるα-defensinと腸内細菌叢の経時変化に対する統計解析2020
- Author(s)
  子安惟、中岡慎、菊池摩仁、中村公則、綾部時芳
- Organizer
  第24回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] 腸内環境と炎症性腸疾患・非感染性疾患―どこまでわかったか2020
- Author(s)
  綾部時芳
- Organizer
  第6回旭川IBD研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] クローン病モデルマウスSAMP1/YitFcの慢性回腸炎の免疫病態2020
- Author(s)
  村山綾菜、中村公則、菊池摩仁、横井友樹、綾部時芳
- Organizer
  第43回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Paneth細胞の機能異常は腸内細菌叢の破綻を介してNASH発症に関与する2020
- Author(s)
  中村駿太、中村公則、菊池摩仁、横井友樹、大平修也、清水由宇、西田琢人、綾部時芳
- Organizer
  第24回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] 腸内環境がalpha-defensin isoformの殺菌活性に及ぼす影響2020
- Author(s)
  篠崎竜我、中村公則、清水由宇、綾部時芳
- Organizer
  第24回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] 膵癌初期発生における膵腸相関2020
- Author(s)
  小野裕介、中村公則、清水由宇、横井友樹、杉本理菜、早川祐子、佐藤裕基、水上裕輔、綾部時芳、奥村利勝
- Organizer
  第24回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] 出生早期からのPaneth細胞発達により制御される腸内細菌定着機構2020
- Author(s)
  西田琢人、中村公則、横井友樹、綾部時芳
- Organizer
  第24回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Alpha-defensin異常による腸内細菌叢の破綻とIBD2020
- Author(s)
  綾部時芳、清水由宇、中村公則
- Organizer
  第127回日本消化器病学会北海道支部例会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] 母子の健康・腸内の環境2020
- Author(s)
  綾部時芳
- Organizer
  Society 5.0北海道の地方創生と未来
- Invited
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Paneth細胞が担う腸内細菌叢の形成からみた疾患リスク上昇メカニズムの理解2020
- Author(s)
  中村公則、綾部時芳
- Organizer
  第24回腸内細菌学会学術集会．シンポジウムI
- Invited
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Paneth細胞が担う腸内細菌との共生と生体恒常性2020
- Author(s)
  綾部時芳
- Organizer
  第57回日本消化器免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Relationship between morphological alteration of Paneth cells and dysbiosis in patients with inflammatory bowel disease2019
- Author(s)
  Nagashima K, Nakamura K, Katsurada T, Shimizu Y, Yokoi Y, Otagiri S, Yamanashi K, Kinoshita K, Onishi R, Sakamoto N, Ayabe T
- Organizer
  4th. Congress of European Crohn’s and Colitis Organisation Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Paneth cell dysfunction in pathophysiology of nonalcoholic steatohepatitis2019
- Author(s)
  Shunta Nakamura, Kiminori Nakamura, Mani Kikuchi, Yuki Yokoi, Shuya Ohira, Yu Shimizu, Takuto Nishida and Tokiyoshi Ayabe
- Organizer
  American Society for Cell Biology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] 母親の高脂肪食摂取が子のPaneth細胞による腸内環境制御に与える影響の解明2019
- Author(s)
  杉本理菜、中村公則、嶋七海、清水由宇、横井友樹、綾部時芳
- Organizer
  第9回オルソオルガノゲネシス検討会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] 腸から健康になる話－腸内環境を整えて元気でいよう2019
- Author(s)
  綾部時芳
- Organizer
  岩見沢市幌向地域ふれあい健康講座
- Invited
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] 多様なα-defensin isoformに対するin vitroにおける効率的なS-S結合導入法の確立2019
- Author(s)
  篠崎竜我、中村公則、清水由宇、綾部時芳
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] ヒト糞便中セロトニンの分析2019
- Author(s)
  平林由紀子、中村公則、曽根原剛志、鈴木大介、半澤悟、清水由宇、相沢智康、中村幸志、玉腰暁子、綾部時芳
- Organizer
  日本質量分析学会第67回質量分析総合討論会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Acetylcholine-induced Paneth cell granule secretion via muscarinic M3 receptor in mouse small intestine2019
- Author(s)
  Yuki Yokoi, Kiminori Nakamura, Rina Sugimoto, Shuya Ohira, Mani Kikuchi and Tokiyoshi Ayabe
- Organizer
  American Society for Cell Biology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Dynamics and mechanisms of Paneth cell granule secretory responses in enteroids2019
- Author(s)
  Yokoi Y, Nakamura K, Sugimoto R, Ohira S, Kikuchi M, Ayabe T
- Organizer
  Hokudai-USC Research Workshop “Gut-Organ Crosstalk”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] 桑葉のα-defensin分泌促進効果と腸内細菌叢制御2019
- Author(s)
  菊池摩仁、中村公則、綾部時芳
- Organizer
  第15回日本食品免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] α-defensinによる腸内細菌叢の制御―共生と排除が疾病の鍵を握る2019
- Author(s)
  綾部時芳
- Organizer
  京滋腸内細菌研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Paneth細胞の発達により制御される腸管恒常性の機構解明2019
- Author(s)
  西田琢人、中村公則、横井友樹、綾部時芳
- Organizer
  第9回オルソオルガノゲネシス検討会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] クローン病マウスモデルSAMP1/YitFcの病態形成におけるPaneth細胞α-defensin misfoldingの関与2019
- Author(s)
  清水由宇、中村公則、菊池摩仁、綾部時芳
- Organizer
  第23回腸内細菌学会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Paneth cell in health and disease - an overview from intestinal homeostasis and inter organ network2019
- Author(s)
  Ayabe T
- Organizer
  Hokudai-USC Research Workshop “Gut-Organ Crosstalk”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Visualization of Paneth cell secretory response to bacterial stimuli using enteroids2019
- Author(s)
  Yokoi Y, Nakamura K, Yoneda T, Nakamura S, Kikuchi M, Ayabe T
- Organizer
  American Society for Cell Biology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] クローン病自然発症モデルSAMP1/YitFcマウスの病状進行に伴う腸内細菌叢および糞便メタボライトの変動2019
- Author(s)
  小松陽介、清水由宇、山野めぐみ、中村公則、綾部時芳、相沢智康
- Organizer
  第71回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] 母親の高脂肪食摂取が子の腸管上皮幹細胞ニッシェに与える影響2019
- Author(s)
  嶋七海、中村公則、杉本理菜、横井友樹、綾部時芳
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] 親の高脂肪食摂取が子のPaneth細胞α-defensinによる腸内環境制御に与える影響2019
- Author(s)
  杉本理菜、中村公則、嶋七海、清水由宇、横井友樹、綾部時芳
- Organizer
  日本農芸化学会2019年度大会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Paneth cell alpha-defensin misfolding leads to dysbiosis and subsequent ileitis in a murine model of Crohn's disease2019
- Author(s)
  Shimizu Y, Nakamura K, Kikuchi M, Ayabe T
- Organizer
  Hokudai-USC Research Workshop “Gut-Organ Crosstalk”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Involvement of Paneth cell α-defensin misfolding in disease progression of SAMP1/YitFc, a murine model of Crohn’s disease2018
- Author(s)
  Shimizu Y, Nakamura K, Kikuchi M, Ayabe T
- Organizer
  第47回日本免疫学会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] 封入体共発現を利用した大量発現系において抗菌ペプチドcryptdin familyの生産性を決定する因子の解析2018
- Author(s)
  保本美穂子、平峰里菜、宋雨遅、佐藤優次、塚本卓、菊川峰志、出村　誠、中村公則、綾部時芳、相沢智康
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] α-defensinが担う腸内細菌の制御と疾病2018
- Author(s)
  綾部時芳
- Organizer
  北海道消化管疾患研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Enteroidを用いたPaneth細胞顆粒の分泌と再形成の可視化2018
- Author(s)
  横井友樹、中村公則、米田　司、菊池摩仁、綾部時芳
- Organizer
  第8回オルソオルガノゲネシス検討会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] ヒト糞便試料の保存条件がメタボロームに与える影響の検討2018
- Author(s)
  包克非，北田直也，稲村優雅，山野めぐみ，久米田博之，熊木康裕，大西裕季，塚本卓，菊川峰志，出村誠，中村公則，綾部時芳，山村凌大, 中村幸志，玉腰暁子，相沢智康
- Organizer
  第57回NMR討論会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Analysisi of the regulation of Paneth cell differentiation in stem cell niche by using intestinal organoid2018
- Author(s)
  大平修也、中村公則、菊池摩仁、横井友樹、杉本理菜、綾部時芳
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02788
[Presentation] Selection and regulation of intestinal microbiota by Paneth cell α-defensins2011
- Author(s)
  Ayabe T, Nakamura K
- Organizer
  XIII International Union of Microbiological Societies 2011 Congress (IUMS2011)
- Place of Presentation
  札幌コンベンションセンター(北海道)(招待講演)
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-23390193
[Presentation] Foods-induced innate immune responses of Paneth cell ・ -defensin uncover novel functions of foods2011
- Author(s)
  Ayabe T, Kuroichi A, Kobayashi M, Nakamura K
- Organizer
  International Society for Nutraceuticais and Functional Foods Annual Conference (ISNFF2011)
- Place of Presentation
  ロイトン札幌(北海道)(招待講演)
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-23390193
[Presentation] マウスα-defensin, cryptdin-4のジスルフィド結合が殺菌活性に及ぼす影響2009
- Author(s)
  増田晃士、坂井直樹、綾部時芳
- Organizer
  第9回日本蛋白質科学会年会(招待講演)
- Place of Presentation
  熊本
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] パネト細胞α-defensinと腸内自然免疫 : クローン病との関わりを含めて2008
- Author(s)
  綾部時芳, 深谷梨恵, 坂井直樹, 前本篤男, 藍田知史, 河野透, 田邊裕貴, 高後裕
- Organizer
  3学会合同大会・第73回日本インターフェロン・サイトカイン学会学術集会/第19回日本生体防御学会学術集会/第45回補体シンポジウム
- Place of Presentation
  札幌市
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-19041005
[Presentation] パネト細胞α-defensinと腸内自然免疫 : クローン病との関わりを含めて2008
- Author(s)
  綾部時芳、深谷梨恵、坂井直樹、前本篤男、蘆田知史、河野透、田邊裕貴、高後裕
- Organizer
  3学会合同大会・第73回日本インターフェロン・サイトカイン学会学術集会/第19回日本生体防御学会学術集会/第45回補体シンポジウム.
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] Paneth cell α-defensin, expression and bactericidal activities in the mouse small intestine2008
- Author(s)
  Fukaya R, Sakai N, Ayabe T.
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] 新規創製した螢光ソルバトクロミック色素プローブを用いた細胞膜ダイナミクス解析2008
- Author(s)
  阿部悠子, 坂井直樹, 山田幸司, 綾部時芳
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸市
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] Regulated roles of Paneth cell α-defensin in the mouse small intetsine2008
- Author(s)
  Fukaya R, Sakai N, and Ayabe T
- Organizer
  American Gastroenterological Association, Digestiove Disease Week
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] 新規創製した螢光ソルバトクロミック色素プローブを用いた細胞膜ダイナミクス解析2008
- Author(s)
  阿部悠子、坂井直樹、山田幸司、綾部時芳
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] 生体応用を目指した螢光ソルバトクロミック色素プローブの高性能化2008
- Author(s)
  阿部悠子、坂井直樹、山田幸司、綾部時芳
- Organizer
  日本分析化学会第57年会
- Place of Presentation
  名古屋
- Year and Date
  2008-09-10
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] 初代内蔵脂肪細胞培養系におけるマクロファージのフェノタイプとその制御2008
- Author(s)
  平理沙、清水恭子、平敏夫、綾部時芳
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] The structural property in bactericidal activities of mouse α-defensin,cryptdin-42008
- Author(s)
  Masuda K, Sakai N, Ayabe T
- Organizer
  8^<th> Awaji International Forum on Infection and Immunity
- Place of Presentation
  Awajishima, Japan
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] パネト細胞α-defensinと腸内自然免疫 : クローン病との関わりを含めて2008
- Author(s)
  綾部時芳, 深谷梨恵, 坂井直樹, 前本篤男, 藍田知史, 河野透, 由邊裕貴, 高後裕
- Organizer
  3学会合同大会・第73回日本インターフェロン・サイトカイン学会学術集会/第19回日本生体防御学会学術集会/第45回補体シンポジウム
- Place of Presentation
  札幌市
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] 小腸上皮におけるセロトニン及びセロトニン受容体の発現解析2008
- Author(s)
  遠藤優子、坂井直樹、綾部時芳
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] Regulated roles of Paneth cell α-defensin in mouse small intestine and its molecular mechanism of bactericidal activity2008
- Author(s)
  Sakai N, Fukaya R, Masuda K, and Ayabe T.
- Organizer
  1^<st> International Symposium on Regulation in Innate Immunity from Recognition molecules to Antimicrobial peptides
- Place of Presentation
  Sapporo, Japan.(シンポジウム)
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] 脂溶性螢光ソルバトクロミック色素を用いた細胞膜ダイナミクス解析の試み2008
- Author(s)
  阿部悠子、坂井直樹、山田幸司、綾部時芳、坂入信夫
- Organizer
  第69回分析化学討論会
- Place of Presentation
  福岡
- Year and Date
  2008-05-01
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] ブルーダイオードレーザー励起が可能な螢光ソルバトクロミック色素プローブの創製と蛍光顕微鏡による細胞膜ダイナミクス観測2008
- Author(s)
  阿部悠子、福原拓馬、坂井直樹、山田幸司、綾部時芳、坂入信夫
- Organizer
  化学系学協会2008年冬季研究発表会
- Place of Presentation
  札幌
- Year and Date
  2008-01-30
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] Paneth cells and their α-defensin in innate immunity and in the pathology of Crohn's disease. Basic Science ; Innate and Aquired Immunity2007
- Author(s)
  Ayabe T, Fukaya R, Sakai N, Maemoto A, Tanabe H, Ashida T, Kohgo Y
- Organizer
  4^<th> JSGE-AGA joint meeting on inflammatory bowel disease
- Place of Presentation
  Aomori, Japan
- Year and Date
  2007-04-19
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] Paneth cell α-defensin, expression and bastericidal secretion in mouse jejunum and ileum2007
- Author(s)
  Fukaya R, Sakai N, Ayabe T
- Organizer
  7^<th> Gordon Research Conference on Antimicrobial Peptides.
- Place of Presentation
  Barga, Italy.(ワークショップ)
- Year and Date
  2007-04-30
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] Expression of Paneth cell α-defensins in the mouse small intestine2007
- Author(s)
  Fukaya R, Sakai N, Ayabe T
- Organizer
  7^<th> Awaji International Forum for infection and Immunity
- Place of Presentation
  Awajishima, Japan
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] Expression of Paneth cell α-defensin and bactericidal reaction in mouse jejunum and ileum2007
- Author(s)
  Fukaya R, Sakai N, and Ayabe T
- Organizer
  13^<th> International Congress of Mucosal Immunology
- Place of Presentation
  Tokyo, Japan.(ワークショップ)
- Year and Date
  2007-07-11
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] 新規螢螢光ソルバトクロミック脂質分子歩ローブの創製と腸上皮細胞ダイナミクス解析の試み2007
- Author(s)
  阿部悠子、福原拓馬、坂井直樹、山田幸司、綾部時芳、坂入信夫
- Organizer
  日本分析化学会第56年会
- Place of Presentation
  徳島
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] opological properties of Paneth cell α-defensin expression and function in the mouse small intestine2007
- Author(s)
  Fukaya R, Sakai N, Ayabe T
- Organizer
  第37回日本免疫学会総会学術集会
- Place of Presentation
  東京
- Year and Date
  2007-10-20
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] Down-regulation of Paneth cell α-defensin expression and function in patients with Crohn's disease2007
- Author(s)
  Maemoto A, Ayabe T, tanabe H, Inaba Y, Ashida T, Fukaya R, Sakai N, Kono T, Kohgo Y
- Organizer
  American Gastroenterological Association, Digestive Disease Week
- Place of Presentation
  Washington DC, USA
- Year and Date
  2007-05-22
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] Paneth cells and their α-defensins in innate immunity and in the pathology of Crohn's disease.2007
- Author(s)
  Ayabe T
- Organizer
  4th. JSGE-AGA Joint Meeting on Inflammatory Bowel Disease.
- Place of Presentation
  Aomori, Japan
- Year and Date
  2007-04-19
- Data Source
  KAKENHI-PROJECT-18390212
[Presentation] Paneth cell α-defensins, expression and bactericidal secretion in mouse jejunum and ileum.2007
- Author(s)
  Ayabe T
- Organizer
  7th Gordon Research Conferrence on Antimicrobial Peptides.
- Place of Presentation
  Barga, Italy
- Year and Date
  2007-04-30
- Data Source
  KAKENHI-PROJECT-19041005
[Presentation] αディフェンシンによる腸内細菌制御からみた健康と疾病
- Author(s)
  綾部時芳
- Organizer
  日本食品免疫学会第5回シンポジウム
- Place of Presentation
  東京大学弥生講堂（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-23390193
[Presentation] Development of antifibrotic therapy targeted to stellate cells for intestinal fibrosis in Crohn's disease
- Author(s)
  Konno M, Nakamura K, Maruyama K, Ayabe T.
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  マリンメッセ福岡（福岡市）
- Data Source
  KAKENHI-PROJECT-23390193
[Presentation] Deficiency of secreted cryptdin-4 detected in a mouse model of Crohn’s disease using a new sandwich ELISA
- Author(s)
  Nakamura K, Kuroishi A, Kono M, Kobayashi M, Ayabe T.
- Organizer
  Experimental Biology 2012
- Place of Presentation
  San Diego Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-23390193

1. KOHGO Yutaka (10133183)

# of Collaborated Projects: 8 results

# of Collaborated Products: 6 results
2. ASHIDA Toshifumi (50261409)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. FUJIMOTO Yoshinori (90292127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. OTAKE Takaaki (10359490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. FUJIYA Mikihiro (80322915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Yokota Takashi (90374321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 坂井直樹 (20422008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 中村公則 (80381276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
9. 奥村利勝 (60281903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 前本篤男 (40400113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 安斉俊久 (60232089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 絹川真太郎 (60399871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 福島新 (40706553)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAKASHIMA Shuichirou

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. ABE Takae

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. KONDOH Miyako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. ITO Masaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. SATO Shintaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 橋本大吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
20. 山崎裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 岡田和隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 菊池摩仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 高桑暁子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ayabe Tokiyoshi 綾部 時芳

綾部 時芳 アヤベ トキヨシ

AYABE Tokiyoshi 綾部 時芳

Research Projects

Research Products

Co-Researchers

Pathogenesis elucidation and treatment development for inflammatory bowel disease from a perspective of the gut ecosystem regulation by alpha-defensinPrincipal Investigator

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Role of alpha-defensins derived from the small intestine and gut microbiota in heart failure

Principal Investigator

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Regulation of intestinal environment by Paneth cells and new therapeutic strategy for inflammatory bowel diseasePrincipal Investigator

Principal Investigator

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腸における感覚の受容と制御の解明が拓く脳腸相関の新展開Principal Investigator

Principal Investigator

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αディフェンシンによる腸内細菌の統御機構からみた炎症性腸疾患の病因解明と新規治療Principal Investigator

Principal Investigator

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腸内細菌の病原性・非病原性と抗菌ペプチドの作用機構の解明Principal Investigator

Principal Investigator

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Research Institution

Regulation of intestinal inflammation by Paneth cell α-defensinPrincipal Investigator

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ヒト腸上皮の微生物認識機構と内因性抗菌ペプチドによる殺菌機能の分子基盤Principal Investigator

Principal Investigator

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微生物感染を契機とするヒト腸管粘膜における自然免疫と獲得免疫間クロストークPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

The role of innate immunity in inflammatory bowel disease

Principal Investigator

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Functional analysis of defensins in human innate intestinall immunity.Principal Investigator

Principal Investigator

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単離細胞を用いたヒト消化管自然免疫機能に関わる分子基盤の解析Principal Investigator

Principal Investigator

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Research Institution

ヒト消化管パネート細胞と微生物との相互作用の自然免疫分子基盤の解明Principal Investigator

Principal Investigator

Ayabe Tokiyoshi 綾部時芳

綾部時芳アヤベトキヨシ

AYABE Tokiyoshi 綾部時芳