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KIMURA Yoshihiro  木村 佳弘

ORCIDConnect your ORCID iD *help
Researcher Number 90301308
Other IDs
Affiliation (based on the past Project Information) *help 2007: 山口大学, 大学院・医学系研究科, 准教授
2006: 山口大学, 大学院・医学系研究科, 助教授
2006: Yamaguchi University, Graduate school of Medicine, Associate Professor, 大学院医学系研究科, 助教授
2004 – 2005: Yamaguchi University, School of Medicine, Associate Professor, 医学部, 助教授
1998 – 2004: Yamaguchi : University School of Medicine, Assistant Professor, 医学部, 講師
1999: Yamaguchi University School of Medicine, Assistant professor, 医学部, 教授
Review Section/Research Field
Principal Investigator
Neurophysiology and muscle physiology / Circulatory organs internal medicine
Except Principal Investigator
General pharmacology / Neurochemistry/Neuropharmacology / General pharmacology / Circulatory organs internal medicine / Anesthesiology/Resuscitation studies / 応用薬理学・医療系薬学
Keywords
Principal Investigator
phospholamban / heart failure / ホスホランバン / phospholipids / oligomer / SERCA / sarcoplasmic reticulum / calcium ATPase / 心不全 / カルシウムATPase … More / 心筋小胞体 / SERCA2a / カルシウムATPaSe / sarco (endo) plasmic reticulum / vascular smooth muscle / cardiac myocytes / 小胞体 / 血管平滑筋 / 心筋 / transgenic mice / cardiac sarcoplasmic reticulum / トランスジェニックマウス / トランスへニックマウス … More
Except Principal Investigator
PSD-95 / Src / PKC / GKAP / Xenopus oocyte / MALS-2 / NMDA受容体 / NMDA receptor / 融合蛋白質 / 心筋小胞体 / 蛋白質間相互作用 / ホスホランバン / oocyte / PDZ / PDZ domain / SERCA / Protein-protein interaction / Xenopus oocytes / 二電極膜電位固定法 / アフリカツメガエル卵母細胞 / 心不全 / スクリーニング / カルシウム・ポンプ / 強心薬 / MAGUKs / SAP102 / molecular therapy / calcium handling / sarcoplasmic reticulum / heart failure / gene delivery / RyRドメインペプチド / 高効率生体内心筋遺伝子導入 / アデノ随伴ウイルスベクター / アデノウイルスベクター / Inhibitor-2 / 高効率生体内遺伝子導入 / 心筋症ハムスター / 蛋白ホスファターゼ1 / ドメイン相関 / リアノジン受容体 / 拡張型心筋症 / 慢性心不全 / 分子標的療法 / カルシウムイオン / 筋小胞体 / バイオテクノロジー / トランスレーショナルリサーチ / 生理学 / 循環器・高血圧 / 遺伝子 / 燐酸化 / src / Screening / Intracellular Ca^<2+> transport / Cardiac sarcoplasmi reticulum / Phospholamban / A drug for heart failure / リン脂質 / 蛋白質相互作用 / 蛋白質結 / 蛋白質精製法 / 細胞内Ca^<2+>輸送 / 心不全治療薬 / insulin / PDZ proteins / NMPA recptor / 亜鉛 / プロテインキナーゼC / チロシンリン酸化酵素 / グルタミン酸受容体 / PDZ protein / インスリン / PDZ蛋白質 / Zinc inhibition / Protein phosphorylation / Dimer formation / Chloride channels / Ion channels / 容積依存性Cl^-チャネル / 2量体 / 酵母two hybrid法 / ClC4 / Cl^-チャネル / チロシン燐酸化 / NMDA受容体チャネル / チャネル / Zn^<2+>感受性 / 蛋白質燐酸化 / 2量体形成 / C1^-チャネル / イオン・チャネル / Two electrode voltage clamp / synthetic RNA / Muscle relaxants / Succinylcholine / Acetylcholine / Neuromuscular junction / Nicotinic acetylcholine receptor / アフリカツメガエル / 合成RNA / 筋弛緩薬 / サクシニルコリン / アセチルコリン / 神経筋接合部 / ニコチン性アセチルコリン受容体 / 3次元結晶 / 2次元結晶 / 蛋白質精製 / 創薬 / アプタマー / 蛋白質結晶 / カルシウム輸送調節 / 創傷治癒 / 上皮進展促進作用 / 組織培養 / 角膜 / Substance P / Insulin-like growth factor / 上皮 / 上皮伸展促進作用 / 細胞内Ca^<2+> / 燐酸化酵素 / IP_3 / サブスタンスP / IGF-1 / 角膜上皮細胞 / 上皮創傷治癒 / 組み換え蛋白質 / カルシウム・イオン / 組換え融合蛋白質 / Ca^<2+>ポンプ Less
  • Research Projects

    (13 results)
  • Research Products

    (4 results)
  • Co-Researchers

    (8 People)
  •  蛋白質結晶構造解析に基づく新たな心不全治療薬デザインのための基礎研究

    • Principal Investigator
      乾 誠
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General pharmacology
    • Research Institution
      Yamaguchi University
  •  Development of molecular therapy correcting abnormal intracellular Ca^<2+> regulation in chronic heart failure

    • Principal Investigator
      MATSUZAKI Masunori
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Yamaguchi University
  •  Analyses of the novel signal transduction mechanisms involved in the homeostasis of the intracellular calcium in the cardiovascular system.Principal Investigator

    • Principal Investigator
      KIMURA Yoshihiro
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurophysiology and muscle physiology
    • Research Institution
      Yamaguchi University
  •  Analysis of the NMDA receptor-PDZ containing complexes as the drug targets

    • Principal Investigator
      YAMADA Yasue
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Yamaguchi University
  •  上皮創傷治癒におけるIGF-1の新たな機能の解明と創薬への応用

    • Principal Investigator
      乾 誠
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General pharmacology
    • Research Institution
      Yamaguchi University
  •  Development of a new drug for heart failure

    • Principal Investigator
      INUI Makoto
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Yamaguchi University
  •  Molecular mechanisms of regulation of NMDA receptor by protein-protein interactions

    • Principal Investigator
      YAMADA Yasue
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Yamaguchi University
  •  Molecular mechanisms of ion channel regulation by a protein-protein interaction

    • Principal Investigator
      INUI Makoto
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Yamaguchi University
  •  Molecular mechanisums of regulation of NMDA receptor by post-synaptic density proteins

    • Principal Investigator
      YAMADA Yasue
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Yamaguchi University
  •  A novel mechanism of serco (endo) plasmic reticulum calcium regulation in the cardiovascular systemPrincipal Investigator

    • Principal Investigator
      KIMURA Yoshihiro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Institution
      Yamaguchi University
  •  新たな作用点を持った強心薬スクリーニング法の開発

    • Principal Investigator
      INUI Makoto
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Yamaguchi University
  •  Study on chronic heart failure using mutant phospholamban transgenic micePrincipal Investigator

    • Principal Investigator
      KIMURA Yoshihiro
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Yamaguchi University
  •  The effects of muscle relaxants on adult-type and fetal-type nictinic acetylcholine receptors

    • Principal Investigator
      YAMADA Yasue
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Yamaguchi University

All 2005 2002

All Journal Article Book

  • [Book] Molecular Mechanisms of Heart Disease2005

    • Author(s)
      Kimura Y.
    • Total Pages
      219
    • Publisher
      Research Signpost
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590194
  • [Book] Molecular Mechanisms of Heart Disease2005

    • Author(s)
      Yoshihiro Kimura
    • Total Pages
      219
    • Publisher
      Research Signpost
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16500264
  • [Journal Article] Molecular Mechanisms of Heart Disease2005

    • Author(s)
      Kimura, Y.
    • Journal Title

      Research Signpost(ed.by Mizukami, Y.)

      Pages: 219-219

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16500264
  • [Journal Article] Reconstitution of the cytoplasmic interaction between phospholamban and Ca^<2+>-ATPase of cardiac sarcoplasmic reticulum.2002

    • Author(s)
      Yoshihiro Kimura
    • Journal Title

      Molecular Pharmacology 61

      Pages: 667-673

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370032
  • 1.  INUI Makoto (70223237)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 0 results
  • 2.  YAMADA Yasue (00166737)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 3.  KO Jie (70314797)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 4.  今田 勝巳 (40346143)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  MATSUZAKI Masunori (60116754)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  YANO Masafumi (90294628)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  IKEDA Yasuhiro (00260349)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  AOKI Hiroki (60322244)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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