Uesaka Toshihiro 上坂敏弘

… Alternative Names

UESAKA Toshihiro 上坂敏弘

上坂敏弘ウエサカトシヒロ

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Researcher Number	90304451
Other IDs
Affiliation (Current)	2025: 神戸大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 神戸大学, 医学研究科, 准教授 2018: 神戸大学, 医学研究科, 准教授 2016 – 2017: 神戸大学, 医学研究科, 講師 2014 – 2015: 神戸大学, 医学(系)研究科(研究院), 講師 2014: 神戸大学, 大学院医学研究科, 講師 … More 2013: 独立行政法人理化学研究所, 発生・再生科学総合研究センター, 客員研究員 2008 – 2010: The Institute of Physical and Chemical Research, 神経分化・再生研究チーム, 研究員 2007: The Institute of Physical and Chemical Research, 神経分化・再生研究チーム, 研究員 2006: 独立行政法人理化学研究所, 神経分化・再生研究チーム, 研究員 2002 – 2003: 広島大学, 原爆放射線医科学研究所, 助手 2000: 広島大学, 原爆放射能医学研究所, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 48010:Anatomy-related / General anatomy (including histology/embryology) / General anatomy (including Histology/Embryology) / Biological Sciences / 環境影響評価(含放射線生物学) Except Principal Investigator Biological Sciences / Biological Sciences
Keywords	Principal Investigator 腸管神経系 / RET / シュワン細胞 / ニューロン新生 / 腸管ニューロン / ヒルシュスプルング病 / 細胞・組織 / 神経堤 / 分化転換 / 疾患モデルマウス … More / 神経堤細胞 / 細胞死 / 腸 / 神経活動操作 / 臓器支配 / 神経系の再生 / 腸管グリア細胞 / 生後ニューロン新生 / 外来神経線維 / 動物 / 解剖学 / 生後ニューロン産生 / シュワン細胞前駆細胞 / シグナル伝達 / 発生・分化 / 恒常的活性化チロシンキナーゼ / 神経栄養因子GDNF / 恒常的活性型チロシンキナーゼ / 変異体ノックインマウス / Retチロシンキナーゼ / 神経分化 / 細胞移動 / 疾患モデル / 腸管神経前駆細胞 / 受容体チロシンキナーゼ / 細胞ソース / シュワン細胞系譜 / 末梢神経前駆細胞 / 神経細胞死 / 腸神経系 / Bcl-xL / Ret / 神経栄養因子 / Hischsprung病 / 腸神経 / GDNF / HB-EGF / Microarray / intestine / regeneration / differentiation / E2F3 / microarray / IEC-6 / Cdx2 / crypt … More Except Principal Investigator Dusp6 / Brainbow / 細胞遊走 / 腸管神経堤細胞 / 血管系 / RET / ケモカイン / CXCR4 / タイムラプスイメージング / ライブセルイメージング / 神経栄養因子 / 神経堤細 / イメージング / ヒルシュスプルング病 / 腸管神経系 / 神経前駆細胞 / 神経堤細胞 / 血管発生 / 細胞移動 / 神経発生 / mcl1 / bcl2ファミリー / 血管内皮細胞増殖因子 / アポトーシス Less

Postnatal neurogenesis in the pelvic visceraPrincipal Investigator
- Principal Investigator
  
  上坂敏弘
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Kobe University
Characterization and induction of enteric neurogenesis by Schwann cell precursorsPrincipal Investigator
- Principal Investigator
  
  Uesaka Toshihiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Kobe University
Glial cells in maintaining homeostasis of the enteric nervous systemPrincipal Investigator
- Principal Investigator
  
  上坂敏弘
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
RET signaling levels control development of the enteric nervous systemPrincipal Investigator
- Principal Investigator
  
  Uesaka Toshihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Kobe University
Schwann cell precursors are a novel cellular source of enteric neuronsPrincipal Investigator
- Principal Investigator
  
  Uesaka Toshihiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Kobe University
  Institute of Physical and Chemical Research
Vascular tissues that supports migration of enteric neural progenitors
- Principal Investigator
  
  ENOMOTO HIDEKI
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
  The Institute of Physical and Chemical Research
Understanding the mechanisms underlying the pathogenesis of Hirschsprung diseasePrincipal Investigator
- Principal Investigator
  
  UESAKA Toshihiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  The Institute of Physical and Chemical Research
腸管神経と腎臓の発生過程の動的観察とGDNFシグナルの役割の解明Principal Investigator
- Principal Investigator
  
  上坂敏弘
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  The Institute of Physical and Chemical Research
小腸放射線障害治療に向けて上皮細胞の分化と再生に関与する遺伝子の研究Principal Investigator
- Principal Investigator
  
  上坂敏弘
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Hiroshima University
アポトーシス抑制遺伝子MCL1の転写調節機構に関する研究
- Principal Investigator
  
  加藤修
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University

All 2022 2019 2018 2017 2016 2015 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] 実験医学増刊(細胞死研究総集編)(神経栄養因子によるニューロンの維持と細胞死 28)2010
- Author(s)
  上坂敏弘、榎本秀樹
- Data Source
  KAKENHI-PROJECT-20590204
[Book] 分子消化器病(ヒルシュスプルング病の発症メカニズム解明につながるモデルマウスの開発 5)2008
- Author(s)
  上坂敏弘、榎本秀樹
- Data Source
  KAKENHI-PROJECT-20590204
[Journal Article] Mice conditionally expressing RET(C618F) mutation display C cell hyperplasia and hyperganglionosis of the enteric nervous system2019
- Author(s)
  Okamoto M, Yoshioka Y, Maeda K, Bito Y, Fukumoto T, Uesaka T, Enomoto H
- Journal Title
  
  Genesis
  
  Volume: Epub ahead of print Issue: 5 Pages: 1-8
- DOI
  10.1002/dvg.23292
- NAID
  120006996909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19527, KAKENHI-PROJECT-17H03550, KAKENHI-PROJECT-16K08466
[Journal Article] Development of the intrinsic and extrinsic innervation of the gut.2016
- Author(s)
  Uesaka T, Young HM, Pachnis V, Enomoto H.
- Journal Title
  
  Dev. Biol.
  
  Volume: 417 Issue: 2 Pages: 158-167
- DOI
  10.1016/j.ydbio.2016.04.016
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08466
[Journal Article] Neuronal differentiation in Schwann cell lineage underlies postnatal neurogenesis in the enteric nervous system.2015
- Author(s)
  Uesaka T, Nagashimada M, Enomoto H
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 35(27) Issue: 27 Pages: 9879-9888
- DOI
  10.1523/jneurosci.1239-15.2015
- NAID
  120005697253
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-25460279
[Journal Article] GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors2013
- Author(s)
  Uesaka T, Nagashimada M, Enomoto H
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 33 Issue: 41 Pages: 16372-16382
- DOI
  10.1523/jneurosci.2079-13.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460279, KAKENHI-PROJECT-25860745
[Journal Article] GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors2013
- Author(s)
  Uesaka T, Nagashimada M, Enomoto, H,
- Journal Title
  
  Jounal of Neuroscience
  
  Volume: 33 Pages: 16372-16382
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22122005
[Journal Article] Neural precursor death is central to the pathogenesis of intestinal aganglionosis in Ret hypomorphic mice2010
- Author(s)
  Uesaka, T., Enomoto, H.
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 30 Pages: 5211-5218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590204
[Journal Article] 神経栄養因子によるニューロンの維持と細胞2010
- Author(s)
  上坂敏弘
- Journal Title
  
  実験医学増刊
  
  Volume: 28 Pages: 101-108
- Data Source
  KAKENHI-PLANNED-22122005
[Journal Article] Neural precursor death is central to the pathogenesis of intestinal aganglionosis in Ret hypomorphic mice.2010
- Author(s)
  Uesaka, T.
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 30 Pages: 5211-5218
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22122005
[Journal Article] Neural precursor death is central to the pathogenesis of intestinal aganglionosis in Ret hypomorphic mice.2010
- Author(s)
  Uesaka T, Enomoto H
- Journal Title
  
  J.Neurosci. 30
  
  Pages: 5211-5218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590204
[Journal Article] Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice2008
- Author(s)
  Uesaka, T., Nagashimada, M., Yonemura, S., Enomoto, H.
- Journal Title
  
  Journal of Clinical Investigation 118
  
  Pages: 1890-1898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590204
[Journal Article] Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice.2008
- Author(s)
  Uesaka T, Nagashimada M, Yonemura S, Enomoto H
- Journal Title
  
  J.Clin.Invest. 118
  
  Pages: 1890-1898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590204
[Journal Article] Conditional ablation of GFRα1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype.2007
- Author(s)
  Uesaka, T., Jain, S., Yonemura, S., Uchiyama, Y., Milbrandt, J., Enomoto, H.
- Journal Title
  
  Development 134
  
  Pages: 2171-2181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790154
[Presentation] Enhanced neurogenesis by Schwann cell precursors in developmental disorders of the enteric nervous system2022
- Author(s)
  上坂敏弘
- Organizer
  第127回日本解剖学会総会
- Data Source
  KAKENHI-PROJECT-21K06754
[Presentation] Enteric neurogenesis from Schwann cell precursors in response to environmental changes2022
- Author(s)
  Toshihiro Uesaka
- Organizer
  International Symposium “Development of the enteric nervous system: cells, signals, genes, and therapy”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06754
[Presentation] 腸管神経系の形成不全後のシュワン細胞系譜からの腸管ニューロン産生2019
- Author(s)
  上坂敏弘
- Organizer
  第124回日本解剖学会総会
- Data Source
  KAKENHI-PUBLICLY-17H05644
[Presentation] 腸管神経系の形成不全後のシュワン細胞系譜からの腸管ニューロン産生2019
- Author(s)
  上坂敏弘
- Organizer
  第124回日本解剖学会総会
- Data Source
  KAKENHI-PROJECT-16K08466
[Presentation] Formation of enteric nervous system from Schwann cell precursors in mouse models of Hirschsprung disease2018
- Author(s)
  Uesaka T
- Organizer
  International Symposium “Development of the enteric nervous system: cells, signals, genes, and therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08466
[Presentation] Formation of enteric nervous system from Schwann cell precursors in mouse models of Hirschsprung disease2018
- Author(s)
  Uesaka T
- Organizer
  International Symposium “Development of the enteric nervous system: cells, signals, genes, and therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05644
[Presentation] Enteric neurogenesis from Schwann cell lineage in mouse models of Hirschsprung disease2017
- Author(s)
  上坂敏弘
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PUBLICLY-17H05644
[Presentation] Enteric neurogenesis from Schwann cell lineage in mouse models of Hirschsprung disease2017
- Author(s)
  Toshihiro Uesaka
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K08466
[Presentation] 腸管神経系の先天的欠損領域におけるシュワン細胞系譜からのニューロン新生2015
- Author(s)
  上坂敏弘　永島田まゆみ　榎本秀樹
- Organizer
  第38回日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460279
[Presentation] Neurogenesis from Schwann cell lineage in mouse models of Hirschsprung disease.2015
- Author(s)
  Uesaka T, Nagashimada M and Enomoto H
- Organizer
  4th International Symposium “Development of the enteric nervous system: cells, signals, genes, and therapy
- Place of Presentation
  Rotterdam, Holland
- Year and Date
  2015-04-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460279
[Presentation] Schwann cell precursor-like cells from the mesentery are a cellular source of enteric neurons2013
- Author(s)
  Uesaka T, Enomoto H
- Organizer
  Gordon Research Conference Neural Crest & Cranial Placodes
- Place of Presentation
  Stonehill College, Easton, MA, USA
- Data Source
  KAKENHI-PROJECT-25460279
[Presentation] 腸管ニューロンの起源となっている新たな細胞ソースの同定2013
- Author(s)
  上坂敏弘、榎本秀樹
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  京都・国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25460279
[Presentation] GDNF Is a Key Regulator for the Formation of the Submucosal Plexus2012
- Author(s)
  T.Uesaka, H.Enomoto
- Organizer
  3^<rd> International Symposium on Development of the Enteric Nervous System : Cells, Signals and Genes
- Place of Presentation
  The University of Hong Kong (Hong Kong, China)
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PLANNED-22122005
[Presentation] 神経栄養因子GDNFは神経堤由来細胞による腸管神経系の二つの神経叢の形成に必須である2011
- Author(s)
  上坂敏弘・榎本秀樹
- Organizer
  第34回日本神経科学大会-こころの脳科学-
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PLANNED-22122005
[Presentation] Bcl-xL-mediated rescue of enteric nervous system formation in a mouse model for Hirschsprung disease.2009
- Author(s)
  Uesaka T, Enomoto H
- Organizer
  2nd International Symposium : Development of the Enteric Nervous System-Cells, Signals and Genes.
- Place of Presentation
  London, UK
- Data Source
  KAKENHI-PROJECT-20590204
[Presentation] Neural precursor death is central to the pathogenesis of intestinal aganglionosis in Ret hypomorphic mice.2009
- Author(s)
  Uesaka T, Enomoto H
- Organizer
  Gordon Research Conference Neurotrophic Factors
- Place of Presentation
  Newport, RI, USA
- Data Source
  KAKENHI-PROJECT-20590204
[Presentation] Bcl-xL-mediated rescue of aganglionosis in a mouse model for Hirschsprung disease.2009
- Author(s)
  Uesaka T, Enomoto H
- Organizer
  第32回日本神経科学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20590204
[Presentation] Bcl-xLによるヒルシュスプルング病モデルマウスの発症抑制2009
- Author(s)
  上坂敏弘
- Organizer
  日本神経科学会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-20590204
[Presentation] Multiple roles of GDNF signaling in development of the enteric nervous system.2008
- Author(s)
  Uesaka T, Enomoto H
- Organizer
  第31回日本神経科学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590204
[Presentation] Hirschsprung's disease model mice: Mice with diminished Ret expression exhibit impaired neuronal survival in the colon.2007
- Author(s)
  Uesaka T
- Organizer
  21th International Mammalian Genome Conference
- Place of Presentation
  Kyoto
- Year and Date
  2007-10-30
- Data Source
  KAKENHI-PROJECT-18790154
[Presentation] Schwann cell precursor-like cells are a novel neuronal origin of the enteric nervous system
- Author(s)
  Toshihiro Uesaka
- Organizer
  47th Annual Meeting of the Japanese Society of Developmental Biologists
- Place of Presentation
  WINC AICHI (Nagoya)
- Year and Date
  2014-05-27 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-25460279
[Presentation] 腸神経系を形成する新たな細胞ソースの同定
- Author(s)
  上坂敏弘・榎本秀樹
- Organizer
  第47回日本発生生物学会
- Place of Presentation
  名古屋
- Year and Date
  2014-05-27 – 2014-05-30
- Data Source
  KAKENHI-PLANNED-22122005

1. ENOMOTO HIDEKI (00360511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. ITO Keisuke (10575468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 加藤修 (90214361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 永島田まゆみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Uesaka Toshihiro 上坂 敏弘

UESAKA Toshihiro 上坂 敏弘

上坂 敏弘 ウエサカ トシヒロ

Research Projects

Research Products

Co-Researchers

Postnatal neurogenesis in the pelvic visceraPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterization and induction of enteric neurogenesis by Schwann cell precursorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Glial cells in maintaining homeostasis of the enteric nervous systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RET signaling levels control development of the enteric nervous systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Schwann cell precursors are a novel cellular source of enteric neuronsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Vascular tissues that supports migration of enteric neural progenitors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the mechanisms underlying the pathogenesis of Hirschsprung diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腸管神経と腎臓の発生過程の動的観察とGDNFシグナルの役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

小腸放射線障害治療に向けて上皮細胞の分化と再生に関与する遺伝子の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アポトーシス抑制遺伝子MCL1の転写調節機構に関する研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 実験医学増刊(細胞死研究総集編)(神経栄養因子によるニューロンの維持と細胞死 28)2010

Author(s)

Data Source

[Book] 分子消化器病(ヒルシュスプルング病の発症メカニズム解明につながるモデルマウスの開発 5)2008

Author(s)

Data Source

[Journal Article] Mice conditionally expressing RET(C618F) mutation display C cell hyperplasia and hyperganglionosis of the enteric nervous system2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Development of the intrinsic and extrinsic innervation of the gut.2016

Author(s)

Uesaka Toshihiro 上坂敏弘

UESAKA Toshihiro 上坂敏弘

上坂敏弘ウエサカトシヒロ