KIRITO Keita 桐戸敬太

… Alternative Names

桐戸敬太キリトケイタ

Less

Researcher Number	90306150
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 教授
Affiliation (based on the past Project Information) *help	2024: 山梨大学, 大学院総合研究部, 教授 2022: 山梨大学, 大学院総合研究部, 教授 2017 – 2020: 山梨大学, 大学院総合研究部, 教授 2014 – 2016: 山梨大学, 総合研究部, 教授 2012 – 2013: 山梨大学, 医学工学総合研究部, 教授 … More 2009 – 2011: University of Yamanashi, 大学院・医学工学総合研究部, 教授 2008: University of Yamanashi, 医学部・附属病院, 准教授 2007 – 2008: University of Yamanashi, 医学部附属病院, 准教授 2006: University of Yamanashi, University of Yamanashi Hospital, Associate Proffessor, 医学部附属病院・助教授, 助教授 2005 – 2006: University of Yamanashi, University of Yamanashi Hospital, Associate Professor, 医学部附属病院, 助教授 2001: 自治医大, 医学部, 助手 1998 – 2001: 自治医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Hematology / Biological Sciences / Hematology / Medium-sized Section 90:Biomedical engineering and related fields
Keywords	Principal Investigator JAK2V617F / 骨髄増殖性腫瘍 / HIF-1 / 活性酸素 / 糖代謝 / 白血病 / GRP78 / Lysyl oxidase / ERストレス / lysyl oxidase … More / metformin / mitochondria / glucose / 低酸素 / 造血幹細胞 / ミトコンドリア / TPO / 組織因子 / 血栓 / メトホルミン / 分子シャペロン / UPR / TIMP / MMP / SAPK/JNK / type1 コラーゲン / 骨髄間質細胞 / MMP9 / ATF4 / 骨髄線維症 / 小胞体ストレス / MCT / 乳酸 / 骨髄線維化 / 線維化 / PP2A / myelofibrosis / P13-kinase / hematopoietic stem cells / reactive oxygen species / Thrombopoietin / ポリフェノール / flavonoid / ROS / Hematopoietic stem cell / PI3キナーゼ / TRAIL / TETファミリー / エピゲノム / JAK２変異 / 低酸素応答 / methylation / WNT5 / Hypoxia / Wnt5 / TET2 / hypoxia / JAK2 / 骨髄増殖性疾患 / JAK2変異 / 低酸素環境 / SHP-2 / GLUT1 / 解糖 / PDK1 / グルコース / PDK-1 / Warbrug効果 / GATA-1 / Stat3 / 巨核球 / 血小板 … More Except Principal Investigator GATA-1 / UT-7 / FKHRL1 / transgenic mice / 白血病 / トロンボポエチン / apoptosis / TRAIL / FOXO3a / 細胞周期 / EPO / all-trans retinoic acid / autocrine / drug-sensitivity / APL / DNAマイクロアレイ / トランスジェニックマウス / Stat3 / エリスロポエチン / アポトーシス / 薬剤耐性 / imatinib / 巨核球造血 / 赤血球造血 / 細胞死 / 細胞内動態 / 分子機械 / ダブルストランドブレイク / DNA / 光細胞毒性 / ジアリールエテン / siRNA / 造血 / 慢性骨髄性白血病 / DNA microarray / cell cycle / megakaryopoiesis / GATA1 / 巨核球 / 赤血球 / CD34 / Stat1 / DAF-16 / タモキシフェン / STAT 1 / STAT 3 / megakaryocytic differentiation / erythroid differentiation / erythropoietin / 顆粒球・マクロファージコロニー刺激因子 / WAF-1 / p21 / チロシンキナーゼ / STAT蛋白 / MAPキナーゼ / STAT1 / STAT3 / 巨核球分化 / 赤芽球分化 / えりすろぽえちん / 家族性血小板機能異常症 / 発現調節 / 遺伝子変異 / 白血球 / 家族性血小板減少症 / RUNX1 / IGF-1 / survivin / 多発性骨髄腫 / HIF-1 / FTY720 / protein phosphatase 2A / 分子標的治療 / オールトランスレチノイン酸 / FOXO3A / 急性前骨髄球性白血病 / 寿命関連遺伝子 / 抗癌薬 / 血液内科学 / HOXB4 / ホメオドメインタンパク質 / 細胞内局在 / Homothorax / MEIS1 / MAPK / HOXA9 / DAF16 / CML / drag resistance / FHKRL1 / Forkhead転写因子 / RARβ / DR5 / CBP / ATRA / GM Less

GRP78の発現異常は骨髄増殖性腫瘍の血栓性病態を誘導するか？Principal Investigator
- Principal Investigator
  
  桐戸敬太
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi
Creation of an optical control molecular mechanical system that independently controls intracellular kinetics and cell death
- Principal Investigator
  
  内田欣吾
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Ryukoku University
Enhanced ER stress response in MPN cells involved in development of myelofibrosis through secretion of GRP78Principal Investigator
- Principal Investigator
  
  KIRITO Keita
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi
Role of glucose metabolism in development of myelofibrosisPrincipal Investigator
- Principal Investigator
  
  KIRITO Keita
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Hypoxia modulate epigenomic response in MPN cellsPrincipal Investigator
- Principal Investigator
  
  KIRITO Keita
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Hypoxia attenuates growth of MPN cells through suppression of SHP-2 expression and subsequent inhibition of JAK2V617F activityPrincipal Investigator
- Principal Investigator
  
  KIRITO Keita
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Analysis of the mechanisms of RUNX1 gene regulation in the pathogenesis of leukemia
- Principal Investigator
  
  SAKOE Kumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Role of glucose metabolism in hematological malignancyPrincipal Investigator
- Principal Investigator
  
  KEITA Kirito
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Development of novel therapeutic strategy for targeting transcription factors expressed in cancer stem cells
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
抗白血病薬によるTRAIL発現誘導と薬剤感受性
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Yamanashi
ホメオボックスHOXA9によるHOXB4の機能抑制と白血病発症
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Thrombopoietin (TPO) regulates HIF-la levels through generation of mitochondrial reactive oxygen speciesPrincipal Investigator
- Principal Investigator
  
  KIRITO Keita
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
The development of targeted therapies using FKHRL1 for the treatment of leukemia
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
  Jichi Medical University
FKHRL1転写因子の機能解析と血液疾患モデルの樹立
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
レチノイン酸による白血病細胞の赤血球分化決定機構の解析
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Stat3による造血調節機構の解析とその破綻による疾患モデルの作成Principal Investigator
- Principal Investigator
  
  桐戸敬太
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Establishment of model system for hematological disorders associated with mutated signal transduction molecules
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
analysis of molecular mechanism of hematopoiesis and hematological disorders
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jich Medical School

[Book] 血液専門医テキスト2011
- Author(s)
  桐戸敬太
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-21591197
[Book] 血液専門医テキスト2011
- Author(s)
  桐戸敬太・小松則夫
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] Phototunable cell killing by photochromic diarylethene of thiazoyl and thienyl derivatives2023
- Author(s)
  Y. Nakagawa, T. Hishida, K. Sumaru, K. Morishita, K. Kirito, S. Yokojima, Y. Sakamoto, S. Nakamura, K. Uchida
- Journal Title
  
  J. Med. Chem.
  
  Volume: - Issue: 8 Pages: 5937-5949
- DOI
  10.1021/acs.jmedchem.3c00164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20J21342, KAKENHI-PROJECT-22K18443
[Journal Article] Expansion of paroxysmal nocturnal hemoglobinuria clones in MPLW515L mutation harboring primary myelofibrosis2020
- Author(s)
  Kirito Keita
- Journal Title
  
  Annals of Hematology
  
  Volume: 99 Issue: 11 Pages: 2707-2709
- DOI
  10.1007/s00277-020-04088-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08319
[Journal Article] Myeloid neoplasm with isolated del(5q) and the MPLW515L mutation fulfills the WHO diagnostic criteria for ET2020
- Author(s)
  Kirito Keita
- Journal Title
  
  International Journal of Hematology
  
  Volume: 112 Issue: 2 Pages: 238-242
- DOI
  10.1007/s12185-020-02872-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08319
[Journal Article] Glycolytic enzyme hexokinase II is a putative therapeutic target in B-cell malignant lymphoma2019
- Author(s)
  Nakajima Kei、Kawashima Ichiro、Koshiisi Megumi、Kumagai Takuma、Suzuki Megumi、Suzuki Jun、Mitsumori Toru、Kirito Keita
- Journal Title
  
  Experimental Hematology
  
  Volume: 78 Pages: 46-55.e3
- DOI
  10.1016/j.exphem.2019.09.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08319, KAKENHI-PROJECT-19K17826
[Journal Article] Bone Marrow Invasion of Small Cell Neuroendocrine Carcinoma of the Endometrium: A Diagnostic Pitfall Mimicking a Haematological Malignancy2019
- Author(s)
  Kawashima Ichiro、Fukasawa Hiroko、Kasai Kazunari、Kumagai Takuma、Koshiishi Megumi、Nakajima Kei、Kondo Tetsuo、Hashi Akihiko、Hirata Shuji、Kirito Keita
- Journal Title
  
  Intern. Med.
  
  Volume: 58 Issue: 17 Pages: 2561-2568
- DOI
  10.2169/internalmedicine.2533-18
- NAID
  130007700192
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2019-09-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08319
[Journal Article] Molecular response of CSF3R T618I harboring chronic neutrophilic leukemia after induction chemotherapy linked to cord blood transplantation2019
- Author(s)
  Kawashima Ichiro、Kumagai Takuma、Suzuki Megumi、Suzuki Jun、Koshiishi Megumi、Nakajima Kei、Kirito Keita
- Journal Title
  
  Annals of Hematology
  
  Volume: 98 Issue: 9 Pages: 2249-2250
- DOI
  10.1007/s00277-019-03733-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08319
[Journal Article] Evaluation of the dose and efficacy of ruxolitinib in Japanese patients with myelofibrosis.2018
- Author(s)
  Kirito K, Okamoto S, Ohishi K, Tauchi T, Handa H, Saito S, Takenaka K, Shimoda K, Oritani K, Akashi K, Okada H, Amagasaki T, Suzuki K, Yonezu T, Komatsu N
- Journal Title
  
  Int J Hematol
  
  Volume: 107(1) Issue: 1 Pages: 92-97
- DOI
  10.1007/s12185-017-2332-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09872, KAKENHI-PROJECT-17H04210, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K09470
[Journal Article] Effect of ruxolitinib therapy on the quality of life of Japanese patients with myelofibrosis.2018
- Author(s)
  Oritani K, Ohishi K, Okamoto S, Kirito K, Komatsu N, Tauchi T, Handa H, Saito S, Takenaka K, Shimoda K, Okada H, Amagasaki T, Wakase S, Shimozuma K, Akashi K
- Journal Title
  
  Curr Med Res Opin
  
  Volume: 34 Issue: 3 Pages: 531-537
- DOI
  10.1080/03007995.2017.1415874
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08894, KAKENHI-PROJECT-16K09872, KAKENHI-PROJECT-15K09470, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-17H04210, KAKENHI-PROJECT-15K07972
[Journal Article] Ruxolitinib is effective and safe in Japanese patients with hydroxyurea-resistant or hydroxyurea-intolerant polycythemia vera with splenomegaly2017
- Author(s)
  Kirito Keita、Suzuki Kenshi、Miyamura Koichi、Takeuchi Masahiro、Handa Hiroshi、Okamoto Shinichiro、Gadbaw Brian、Yamauchi Kyosuke、Amagasaki Taro、Ito Kazuo、Hino Masayuki
- Journal Title
  
  International Journal of Hematology
  
  Volume: 107 Issue: 2 Pages: 173-184
- DOI
  10.1007/s12185-017-2333-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09470
[Journal Article] Clinical Efficacy and Safety of First-Line Dasatinib Therapy and the Relevance of Velocity of BCR-ABL1 Transcript Decline for Achievement of Molecular Responses in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia: Report from the Juntendo Yamanashi Cooperative Study Group2017
- Author(s)
  Takaku Tomoiku、Iriyama Noriyoshi、Mitsumori Toru、Sato Eriko、Gotoh Akihiko、Kirito Keita、Noguchi Masaaki、Koike Michiaki、Sakamoto Junichi、Oba Koji、Komatsu Norio
- Journal Title
  
  Oncology
  
  Volume: 94 Issue: 2 Pages: 85-91
- DOI
  10.1159/000481945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09470
[Journal Article] Metformin inhibits JAK2V617F activity in MPN cells by activating AMPK and PP2A complexes containing the B56alpha subunit2016
- Author(s)
  Kawashima I, Kirito K
- Journal Title
  
  Experimental Hematology
  
  Volume: 44 Issue: 12 Pages: 1156-1165
- DOI
  10.1016/j.exphem.2016.08.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09470
[Journal Article] Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells2015
- Author(s)
  Kawashima, I. Mitsumori, T. Nozaki, Y. Yamamoto, T. Shobu-Sueki, Y. Nakajima, K. Kirito, K.
- Journal Title
  
  Exp Hematol
  
  Volume: in press Issue: 7 Pages: 524-533.e1
- DOI
  10.1016/j.exphem.2015.03.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591386, KAKENHI-PROJECT-15K09470
[Journal Article] JAK2V617F mutation status and allele burden in classical Ph-negative myeloproliferative neoplasms in Japan.2014
- Author(s)
  Edahiro Y, Morishita S, Takahashi K, Hironaka Y, Yahata Y, Sunami Y, Shirane S, Tsutsui M, Noguchi M, Koike M, Imai K, Kirito K, Noda N, Sekiguchi Y, Tsuneda S, Ohsaka A, Araki M, Komatsu N
- Journal Title
  
  Int J Hematol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591386
[Journal Article] Anaplastic large cell lymphoma with paraneoplastic neutrophilia: an association between IL-17 elevation and aggressive disease progression.2014
- Author(s)
  Sueki Y, Nozaki Y, Kawashima I, Yamamoto T, Nakajima K, Mitumori T, Kirito K.
- Journal Title
  
  Int J Hematol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591386
[Journal Article] Hypoxia inhibits JAK2V617F activation via suppression of SHP-2 function in myeloproliferative neoplasm cells2014
- Author(s)
  Mitsumori, T. Nozaki, Y. Kawashima, I. Yamamoto, T. Shobu, Y. Nakajima, K. Morishita, S. Komatsu, N. Kirito, K.
- Journal Title
  
  Exp Hematol
  
  Volume: 42 Issue: 9 Pages: 783-792.e1
- DOI
  10.1016/j.exphem.2014.05.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591386
[Journal Article] Rituximab activates Syk and AKT in CD20-positive B-cell lymphoma cells dependent on cell membrane cholesterol levels2013
- Author(s)
  Nozaki, Y. Mitumori, T. Yamamoto, T. Kawashima, I. Shobu, Y. Hamanaka, S. Nakajima, K. Komatsu, N. Kirito, K.
- Journal Title
  
  Experimental Hematology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591386
[Journal Article] Alternately binding probe competitive PCR as a simple2011
- Author(s)
  Morishita S, Komatsu N, Kirito K, Koda AH, Sekiguchi Y, Tsuneda S, Noda N
- Journal Title
  
  cost-effective, and accurate quantification method for JAK2V617F allele burden in myeloproliferative neoplasms Leukemia Research
  
  Volume: 35 Pages: 1632-1636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] Romiplostim for the treatment ofchronic immune thrombocytopenia inadult Japanese patients : a double-blind, randomized Phase iii clinicaltrial2011
- Author(s)
  Shirasugi Y, Ando K, Miyazaki K, Tomiyama Y, Okamoto S, Kurokawa M, Kirito K, Yonemura Y, Mori S, Usuki K, Iwato K, Hashino S, Wei H, Lizambri R
- Journal Title
  
  International Journal of Hematology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] NF-κB mediates aberrantactivation of HIF-1 in malignantlymphoma2010
- Author(s)
  Qiao Q, Nozaki Y, Sakoe K, Komatsu N, Kirito K
- Journal Title
  
  Exp Hematol
  
  Volume: 38(12) Pages: 1199-1208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] FOXO3A as a key molecule forall-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia2010
- Author(s)
  Sakoe Y, Sakoe K, Kirito K, Ozawa K, Komatsu N
- Journal Title
  
  Blood
  
  Volume: 115(18) Pages: 3787-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] FOXO3A as a key molecule for all-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia2010
- Author(s)
  Sakoe Y, Sakoe K, Kirito K, Ozawa K, Komatsu N.
- Journal Title
  
  Blood 115
  
  Pages: 3787-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] NF-κB mediates aberrant activation of HIF-1 in malignant lymphoma2010
- Author(s)
  Qiao Q, Nozaki Y, Sakoe K, Komatsu N, Kirito K.
- Journal Title
  
  Exp Hematol 38
  
  Pages: 1199-1208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] Inhibition of HIF-1 function enhances the sensitivity of multiple myeloma cells to melphalan2009
- Author(s)
  ongzhen Hu, Kirito K, Yoshida K, Mitsumori T, Nakajima K, Nozaki Y, Hamanaka S, Nagashima T, Kunitama M, Sakoe K, Komatsu N.
- Journal Title
  
  Molecular cancer therapeutics 8
  
  Pages: 2329-2338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] HIF-1 prevents the overproduction of mitochondrial ROS after cytokine stimulation through induction of PDK-12009
- Author(s)
  Kirito K, Hu Y, Komatsu N.
- Journal Title
  
  Cell cycle 8
  
  Pages: 2844-2849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] HIF-1prevents the overproduction of mitochondrial ROS after cytokine stimulation through induction of PDK-12009
- Author(s)
  Kirito K, Hu Y, Komatsu N
- Journal Title
  
  Cell cycle
  
  Volume: 8 Pages: 2844-2849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myelomacells to melphalan2009
- Author(s)
  Hu Y, Kirito K, Yoshida K, MitsumoriT, Nakajima K, Nozaki Y, Hamanaka S, Nagashima T, Kunitama M, Sakoe K, Komatsu N
- Journal Title
  
  Molecular cancer therapeutics
  
  Volume: 8 Pages: 2329-2338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] HIF-1 prevents the overproduction of mitochondrial ROS after cytokine stimulation through induction of PDK-1.2009
- Author(s)
  Kirito K
- Journal Title
  
  Cell cycle 8
  
  Pages: 2844-2849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] Thrombopoietin (TPO) regulates HIF-1alpha levels through generation of mitochondrial reactive oxygen species2008
- Author(s)
  Yoshida K, Kirito K, Yongzhen H, Ozawa K, Kaushansky K, Komatsu N
- Journal Title
  
  International journal of hematology 88
  
  Pages: 43-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies.2008
- Author(s)
  Kirito K
- Journal Title
  
  Haematologica 93
  
  Pages: 155-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Long-term results of dose-intensive chemotherapy with G-CSF support (TCC-NHL-91) for advanced intermediate-grade non-Hodgkin's lymphoma : a review of 59 consecutive cases treated at a single institute2008
- Author(s)
  Akulsu, M., Tsiinoda, S., lzumi, T., Tanaka, M., Kalaiio, S., Inoue, K., Igarashi, S., Hirabayashi, K., Furukawa, Y., Ohmine, K., Saio, K., Kobayashi, H., Ozawa, K., Kirito, K., Nagashima, T., Teramukai, S., Fukushima, M., Kano, Y.
- Journal Title
  
  Oncol Res 17
  
  Pages: 137-149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies.2008
- Author(s)
  Kirito K, Sakoe K, Shinoda D, Takiyama Y, Kaushansky K, Komatsu N
- Journal Title
  
  Haematologica 93
  
  Pages: 155-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid maligna2008
- Author(s)
  Kirito K
- Journal Title
  
  Haematologica 93
  
  Pages: 155-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Thrombopoietin (TPO) regulates HIF-1a levels through generation of mitochondrial reactive oxygen species.2008
- Author(s)
  Yoshida K, Kirito K, Yongzhen H, Ozawa K, Kaushansky K, Komatsu N.
- Journal Title
  
  Int J Hematol 88
  
  Pages: 43-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] .A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies2008
- Author(s)
  K. Kirito, K. Sakoe, D. Shinoda, Y. Takiyama, K. Kaushansky and N. Komatsu
- Journal Title
  
  Haematologica 93
  
  Pages: 155-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies2008
- Author(s)
  Kirito K, Sakoe K, Shinoda D, Takiyama Y, Kaushansky K, Komatsu N.
- Journal Title
  
  Haematologica 93
  
  Pages: 155-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Long-term results of dose-intensive chemotherapy with G-CSF support (TCC-NHL-91) for advanced intermediate-grade non-Hodgkin's lymphoma : a review of 59 consecutive cases treated at a single institute2008
- Author(s)
  Akutsu M, Tsunoda S, Izumi T, Kirito, K(18人)
- Journal Title
  
  Oncology research 17
  
  Pages: 137-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] Thrombopoietin (TPO) regulates HIF-1a levels through generation of mitochondrial reactive oxygen species2008
- Author(s)
  Yoshida K, Kirito K, Yongzhen H,Ozawa K, Kaushansky K, Komatsu N.
- Journal Title
  
  Int J Hematol 88(1)
  
  Pages: 43-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Throrabopoietin (TPO) regulates HIF-lalpha levels through generation of mitochondrial reactive oxvgen species2008
- Author(s)
  Yoshida, K., Kirito, K., Yongzhen, H., Ozawa, K., Kaushansky, K., Komatsu, N.
- Journal Title
  
  Int J Hematol 88
  
  Pages: 43-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies2008
- Author(s)
  Kirito K, Sakoe K, Shinoda D, Takiyama Y, Kaushansky K, Komatsu N
- Journal Title
  
  Haematologica 93
  
  Pages: 155-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] .Active FKHRL1 overcomes imatinib resistance in chronic myelogenous leukemia-derived cell lines via the production of tumor necrosis factor-related apoptosis-inducing ligand2007
- Author(s)
  S. Kikuchi, T. Nagai, M. Kunitama, K. Kirito, K. Ozawa and N. Komatsu
- Journal Title
  
  Cancer Science 98
  
  Pages: 1949-1958
- NAID
  10019996600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] Active FKHRL1 overcomes imatinib resistance in chronic myelogenous leukemia-derived cell lines via the production of tumor necrosis factor-related apoptosisinducing ligand2007
- Author(s)
  Kikuchi S, Nagai T, Kunitama M, Kirito K, Ozawa K, Komatsu N.
- Journal Title
  
  Cancer Sci 98(12)
  
  Pages: 1949-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus-negative leukemia cell lines2007
- Author(s)
  Furukawa Y, Vu HA, Akutsu M, Kirito, K(11人)
- Journal Title
  
  Leukemia 21
  
  Pages: 1005-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus-negative leukemia cell lines2007
- Author(s)
  Y. Furukawa, H. A. Vu, M. Akutsu, T. Odgerel, T. Izumi, S. Tsunoda, Y. Matsuo, K. Kirito, Y. Sato, H. Mano and Y. Kano
- Journal Title
  
  Leukemia 21
  
  Pages: 1005-1014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines2007
- Author(s)
  Furukawa Y, Vu HA, Akutsu M, Odgerel T, Izumi T, Tsunoda S, Matsuo Y, Kirito K, Sato Y, Mano H, Kano Y
- Journal Title
  
  Leukemia (In press)
- Data Source
  KAKENHI-PROJECT-17659291
[Journal Article] Activation of FKHRL1 plays an important role in protecting erythroid cells from erythropoietin deprivation-induced apoptosis in a human erythropoietin-dependent leukemia cell line, UT-7/EPO2007
- Author(s)
  Uchida M, Kirito K, Endo H, Ozawa K, Komatsu N
- Journal Title
  
  International journal of hematology 86
  
  Pages: 315-24
- NAID
  10019990096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines2007
- Author(s)
  Furukawa Y, Vu HA, Akutsu M, Odgerel T, Izumi T, Tsunoda S, Matsuo Y, Kirito K, Sato Y, Mano H, Kano Y.
- Journal Title
  
  21(5)
  
  Pages: 1005-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines.2007
- Author(s)
  Furukawa Y, Vu HA, Akutsu M, Odgerel T, Izumi T, Tsunoda S, Matsuo Y, Kirito K, Sato Y, Mano H, Kano Y.
- Journal Title
  
  Leukemia (In press)
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Active FKHRL1 overcomes imatinib resistance in chronic myelogenous leukemia-derived cell lines via the production of tumor necrosis factor-related apoptosis-inducing ligand2007
- Author(s)
  Kikuchi S, Nagai T, Kunitama M, Kirito K, Ozawa K, Komatsu N.
- Journal Title
  
  Cancer science 98
  
  Pages: 1949-58
- NAID
  10019996600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] Activation of FKHRL1 plays an important role in protecting erythroid cells from erythropoietin deprivation-induced apoptosis in a human erythropoietin-dependent leukemia cell line, UT-7/EPO2007
- Author(s)
  M. Uchida, K. Kirito, H. Endo, K. Ozawa and N. Koroatsu
- Journal Title
  
  Int J Hematol 86
  
  Pages: 315-324
- NAID
  10019990096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] Activation of FKHRL1 plays an important role in protecting erythroid cells from erythropoietin deprivation-induced apoptosis in a human erythropoietin-dependent leukemia cell line2007
- Author(s)
  Uchida M, Kirito K, Endo H, Ozawa K, Komatsu N.
- Journal Title
  
  UT-7/EPO. Int J Hematol 86(4)
  
  Pages: 315-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Transcriptional Regulation of Megakaryopoiesis : "TPO signaling andnuclear factors"2006
- Author(s)
  Kirito, K
- Journal Title
  
  Current Opinion in Hematology In press
- Data Source
  KAKENHI-PROJECT-17659291
[Journal Article] Transcriptional regulation of megakaryopoiesis : thrombopoietin signaling and nuclear factors2006
- Author(s)
  Kirito K et al.
- Journal Title
  
  Curr Opin Hematol 13・3
  
  Pages: 151-156
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] K.Transcriptional regulation of megakaryopoiesis: thrombopoietin signaling and nuclear factors2006
- Author(s)
  Kirito K, Kaushansky K.
- Journal Title
  
  Curr Opin Hematol 13(3)
  
  Pages: 151-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Transcriptional regulation of megakaryopoiesis : thrombopoiet in signaling and nuclear factors.2006
- Author(s)
  Kirito K.
- Journal Title
  
  Curr Opin Hematol 13・3
  
  Pages: 151-156
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Transcriptional Regulation of Megakaryopoiesis : "TPO signaling and nuclear factors"2006
- Author(s)
  Kirito, K
- Journal Title
  
  Current Opinion in Hematology (In press)
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Transcriptional regulation of megakaryopoiesis : thrombopoietin signaling and nuclear factors.2006
- Author(s)
  Kirito K, Kaushansky K
- Journal Title
  
  Curr Opin Hematol 13.3
  
  Pages: 151-156
- Data Source
  KAKENHI-PROJECT-17659291
[Journal Article] Transcriptional regulation of megakaryopoiesis : thrombopoietin signaling and nuclear factors.2006
- Author(s)
  Kirito K, Kaushansky K.
- Journal Title
  
  Curr Opin Hematol 13.3
  
  Pages: 151-156
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Transcriptional regulation of megakaryopoiesis : thrombopoietin signaling and nuclear factors2006
- Author(s)
  K.Kirito, K.Kaushansky.
- Journal Title
  
  Curr Opin Hematol 13-3
  
  Pages: 151-6
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Thrombopoietin stimulates vascular endothelial cell growth factor (VEGF) production in hematopoietic stem cells2005
- Author(s)
  Kirito, K et al.
- Journal Title
  
  Cell Cycle 4・12
  
  Pages: 1729-1731
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Thrombopoietin stimulates vascular endothelial cell growth factor (VEGF) production in hematopoietic stem cells2005
- Author(s)
  Kirito, K
- Journal Title
  
  Cell Cycle 4・12
  
  Pages: 1729-1731
- Data Source
  KAKENHI-PROJECT-17659291
[Journal Article] Thrombopoietin enhances expression of vascular endothelial growth factor(VEGF) in primitive hematopoietic cells through induction of HIF-la.2005
- Author(s)
  Kirito, K
- Journal Title
  
  Blood 105・11
  
  Pages: 4258-4263
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390306
[Journal Article] Thrombopoietin enhances expression of vascular endothelial growth factor(VEGF) in primitive hematopoietic cells through induction of HIF-1a.2005
- Author(s)
  Kirito, K
- Journal Title
  
  Blood 105・11
  
  Pages: 4258-4263
- Data Source
  KAKENHI-PROJECT-15390306
[Journal Article] Thrombopoietin stimulates vascular endothelial cell growth factor (VEGF) production in hematopoietic stem cells2005
- Author(s)
  K.Kirito, K.Kaushansky.
- Journal Title
  
  Cell Cycle 4-12
  
  Pages: 1729-31
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1alpha2005
- Author(s)
  K.Kirito, N.Fox, N.Komatsu, K.Kaushansky.
- Journal Title
  
  Blood 105-11
  
  Pages: 4258-63
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Thrombopoietin stimulates vascular endothelial cell growth factor(VEGF) production in hematopoietic stem cells2005
- Author(s)
  Kirito, K
- Journal Title
  
  Cell Cycle 4・12
  
  Pages: 1729-1731
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Thrombopoietin enhances expression of vascular endothelial growth factor(VEGF) in primitive hematopoietic cells through induction of HIF-1a.2005
- Author(s)
  Kirito, K
- Journal Title
  
  Blood 105・11
  
  Pages: 4258-4263
- Data Source
  KAKENHI-PROJECT-17014037
[Journal Article] E Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-lalpha2005
- Author(s)
  Kirito, K et al.
- Journal Title
  
  Blood 105・11
  
  Pages: 4258-4263
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1a2005
- Author(s)
  Kirito, K
- Journal Title
  
  Blood 105・11
  
  Pages: 4258-4263
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390306
[Journal Article] Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1alpha.2005
- Author(s)
  Kirito, K
- Journal Title
  
  Blood 105・11
  
  Pages: 4258-4263
- Data Source
  KAKENHI-PROJECT-17659291
[Journal Article] Thrombopoietin enhances expression of vascular endothelial growth factor(VEGF) in primitive hematopoietic cells through induction of HIF-1alpha.2005
- Author(s)
  Kirito, K
- Journal Title
  
  Blood 105・11
  
  Pages: 4258-4263
- Data Source
  KAKENHI-PROJECT-17591005
[Presentation] Aberrant regulation of extracellular matrix homeostasis by JAK2V617F2020
- Author(s)
  Kei Nakajima, Keita Kirito
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08319
[Presentation] 骨髄増殖腫瘍における18F-FDG-PET/CT所見2019
- Author(s)
  鈴木潤、佐藤葉子、輿石めぐみ、鈴木愛、川島一郎、中嶌圭、桐戸敬太
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08319
[Presentation] APL細胞の細胞表面マーカーの特徴と限界2019
- Author(s)
  細川恵理子, 輿石めぐみ, 鈴木潤, 熊谷拓磨, 鈴木愛, 川島一郎, 中島圭, 桐戸敬太
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08319
[Presentation] 日本における二次性骨髄線維症の予後予測モデルの比較検討2019
- Author(s)
  鈴木愛、鈴木潤、輿石めぐみ、川島一郎、中嶌圭、三森徹、桐戸敬太
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08319
[Presentation] CSF3RT618I変異検出により診断することができた慢性好中球性白血病2019
- Author(s)
  川島一郎、鈴木潤、熊谷琢磨、鈴木愛、輿石めぐみ、中嶌圭、桐戸敬太
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08319
[Presentation] 骨髄線維症に対する治療　造血幹細胞移植か?薬物療法か?2019
- Author(s)
  桐戸敬太、竹中克斗、池田和彦
- Organizer
  第81回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08319
[Presentation] 8p11骨髄増殖症候群と類縁疾患2019
- Author(s)
  桐戸敬太
- Organizer
  第81回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08319
[Presentation] Metformin suppresses expression of pre-fibrotic Enzyme Lysyl-oxidase levels through Inhibition of UPR in MPN cells2018
- Author(s)
  Megumi Suzuki, Jun Shuzuki, Megumi Koshiishi, Ichiro kawashima, Kei Nakajima, Keita Kirito
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08319
[Presentation] Metformin suppresses expression of pre-fibrotic Enzyme Lysyl-oxidase levels through Inhibition of UPR in MPN cells2018
- Author(s)
  Megumi Suzuki, Jun Shuzuki, Megumi Koshiishi, Ichiro kawashima, Kei Nakajima, Keita Kirito
- Organizer
  第60回米国血液学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08319
[Presentation] Aberrant Activation of NF-κB and Hypoxia Enhances Glycolytic Enzyme Hexokinase II Expression in B-Cell Lymphoma through Activation of HIF-12017
- Author(s)
  Nakajima, Kei Kirito, Keita Kawashima, Ichiro Koshiishi, Megumi Kumagai, Takuma Mitsumori, Toru
- Organizer
  第５９回米国血液学会
- Data Source
  KAKENHI-PROJECT-15K09470
[Presentation] Metformin Inhibits JAK2V617F Activity By Activating AMPK and PP2A Containing B56 Alpha Subunits in MPN Cells2015
- Author(s)
  Ichiro kawashima, Keita Kirito
- Organizer
  57th ASH Annual Meeting and Exposition
- Place of Presentation
  Orlando, FL, USA
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09470
[Presentation] Metformin inhibits the growth of JAK2V617F-harboring cells through direct inhibition of JAK2V617F2015
- Author(s)
  Ichiro kawashima, Keita Kirito
- Organizer
  第77回日本血液学会
- Place of Presentation
  石川県金沢市
- Year and Date
  2015-10-06
- Data Source
  KAKENHI-PROJECT-15K09470
[Presentation] 分子病態からみたMPN2014
- Author(s)
  桐戸敬太
- Organizer
  第７６回日本血液学会学学術集会
- Place of Presentation
  大阪国際会議場　（　大阪府大阪市北区）
- Invited
- Data Source
  KAKENHI-PROJECT-24591386
[Presentation] Metformin Exerts Anti-Leukemic Effects Via Direct Inhibition Of Oncogenic Kinase Activity In Leukemia Cells Derived From Myeloproliferative Neoplasms2013
- Author(s)
  I kawashima , K Kirito
- Organizer
  第５５回米国血液学会
- Place of Presentation
  New Orleans convention center (New Orelans, USA)
- Data Source
  KAKENHI-PROJECT-24591386
[Presentation] Rituximab Activation of AKTand Pathways Is Dependent on Membrane Lipid Raft Cholesterol Levels in Lymphoma Cells2011
- Author(s)
  Nozaki Y, Mitsumori T, Komatsu N, Kirito K
- Organizer
  第53回米国血液学会
- Place of Presentation
  SanDiego
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] The membrane cholesterollevels of B cell lymphoma cells determine rituximab-induced AKT activation2011
- Author(s)
  Nozaki Y, Mitsumori T, Komatsu N, Kirito K
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] MPN細胞において、低酸素状態はSHP-2誘導を介しJAK2V617Fの活性化を阻害する2011
- Author(s)
  三森徹、野崎由美、川島一郎、山本健夫、濱中聡至、中嶌圭、小松則夫、桐戸敬太
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] MPNの分類と病態2011
- Author(s)
  桐戸敬太
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] Lipid RaftはリツキシマブによるHIF-1活性化を規定する2011
- Author(s)
  野崎由美、Qiao Qiao、迫江公己、小松則夫、桐戸敬太
- Organizer
  第8回がんとハイポキシア研究会
- Place of Presentation
  札幌市
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] MPNの分類と病態2011
- Author(s)
  桐戸敬太
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋国際会議場(愛知県)(招待講演)
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] 真性赤血球増加症における血栓症のリスク解析2011
- Author(s)
  山本健夫、三森徹、川島一郎、濱中聡至、野崎由美、中嶌圭、小松則夫、桐戸敬太
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] 低酸素環境はJAK2V617F陽性MPN細胞の増殖を抑制する2011
- Author(s)
  三森徹、野崎由美、桐戸敬太
- Organizer
  第8回がんとハイポキシア研究会
- Place of Presentation
  札幌市
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] レナリドマイド投与後に亜急性甲状腺炎を発症した5q-症候群の1例2011
- Author(s)
  菖蒲侑希、三森徹、山本健夫、濱中聡至、野崎由美、中嶌圭、桐戸敬太
- Organizer
  第166回日本血液学会例会
- Place of Presentation
  東京都
- Year and Date
  2011-07-02
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] Hypoxia Blocks Activation of JAK2V617F Through Suppression of SHP-2 Expression in MPN cells2011
- Author(s)
  Mitsumori T, Nozaki Y, Komatsu N, Kirito K
- Organizer
  第53回米国血液学会
- Place of Presentation
  SanDiego
- Year and Date
  2011-12-11
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] 転写因子HIFによる赤血球造血制御2010
- Author(s)
  桐戸敬太
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2010-10-25
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] 転写因子HIFによる赤血球造血抑制2010
- Author(s)
  桐戸敬太
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] MPNの分子病態; JAK2変異同定より5年のあゆみ2010
- Author(s)
  桐戸敬太
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2010-10-25
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] リツキシマブによるHIF-1活性化にはLipid Raftが関与する2010
- Author(s)
  野崎由美、Qiao Qiao、迫江公己、小松則夫、桐戸敬太
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] 若年発症の菌状息肉症(腫瘍期)の一例2010
- Author(s)
  篠田大輔、三森徹、永嶋貴博、中嶌圭、野崎由美、濱中聡至、桐戸敬太
- Organizer
  第574回日本内科学会関東地方会例会
- Place of Presentation
  東京都
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] MPNの分子病態: JAK2変異同定より5年のあゆみ2010
- Author(s)
  桐戸敬太
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] 低酸素によるJAK2V617F活性制御2010
- Author(s)
  三森徹、野崎由美、小松則夫、桐戸敬太
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] 骨髄増殖性腫瘍の分子基盤と新たな治療展開2010
- Author(s)
  桐戸敬太
- Organizer
  第11回日本検査血液学会学術集会
- Place of Presentation
  東京都
- Year and Date
  2010-07-24
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] 膵癌が疑われた膵臓原発の髄外性形質細胞腫の1例2010
- Author(s)
  沼田裕樹,小佐野雅識,川島一郎,中嶌圭,野崎由美,山本健夫,三森徹,小松則夫,桐戸敬太
- Organizer
  第573回日本内科学会関東地方会例会
- Place of Presentation
  東京都
- Year and Date
  2010-07-11
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] 治療難治性であったTリンパ芽球性リンパ腫の一例2010
- Author(s)
  雨宮憲彦,小岩井孝夫,風間文智,畑山一貴,遠藤武,高野勝弘,三森徹,桐戸敬太,小松則夫,尾崎由基男
- Organizer
  第11回日本検査血液学会学術集会
- Place of Presentation
  東京都
- Year and Date
  2010-07-24
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] たこつぼ型心筋症を発症した多発性骨髄腫2009
- Author(s)
  三森徹,中嶌圭,野崎由美,濱中聡至,永嶋貴博,岩尾憲明,桐戸敬太,小松則夫
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都府
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] リツキシマブはHIF-1を介して抗アポトーシス蛋白Survivinを誘導する2009
- Author(s)
  野崎由美,桐戸敬太, QiaoQiao,迫江公己,小松則夫
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都府
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] HIF-1 Prevents Hematopoietic Cells from Cell Damage by Overproduction of Mitochondrial ROS after Cytokine Stimulation through Induction of PDK-12008
- Author(s)
  Keita Kirito, Kozue Yoshida, Yongzhen Hu, Qiao Qiao, Kumi Sakoe, and Norio Komatsu
- Organizer
  第50回米国血液学会
- Place of Presentation
  San Francisco
- Year and Date
  2008-12-07
- Data Source
  KAKENHI-PROJECT-18390282
[Presentation] HIF-1 Prevents Hematopoietic Cells from Cell Damage by Overproduction of Mitochondrial ROS after Cytokine Stimulation through Induction of PDK-1.2008
- Author(s)
  Keita K
- Organizer
  第50回米国血液学会
- Place of Presentation
  San Francisco
- Year and Date
  2008-12-07
- Data Source
  KAKENHI-PROJECT-18390282
[Presentation] HIF-1 Prevents Hematopoietic Cells from Cell Damage by Overproduction of Mitochondrial ROS after Cytokine Stimulation through Induction of PDK-12008
- Author(s)
  Kirito, K., Yoshida, K., Yongzhen H., Qiao Q., Sakoe, K., Komatsu, N.
- Organizer
  50 th Annual Meeting of American Society of Hematology
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2008-12-07
- Data Source
  KAKENHI-PROJECT-19591103
[Presentation] RUNX1の発現調節異常による白血病発症のメカニズムの解析.2008
- Author(s)
  桐戸敬太
- Organizer
  日本臨床血液学会
- Place of Presentation
  京都
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20591114
[Presentation] RUNX1 の発現調節異常による白血病発症のメカニズムの解析2008
- Author(s)
  桐戸敬太、迫江公己, 他
- Organizer
  日本臨床血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20591114
[Presentation] HIF-1 Prevents Hematopoietic Cells from Cell Damage by Overproduction of Mitochondrial ROS after Cytokine Stimulation through Induction of PDK-12008
- Author(s)
  1.Kirito K, Yoshida K, Hu Y, Qiao Q, Sakoe K, Komatsu N.
- Organizer
  第50回米国血液学会
- Place of Presentation
  San Fransico
- Year and Date
  2008-12-07
- Data Source
  KAKENHI-PROJECT-19591103
[Presentation] HIF-1 Supports the Survival of Multiple Myeloma Cells through the Induction of Survivin Gene2007
- Author(s)
  Kirito K, Yongzhen H, Yoshida K, et.al.
- Organizer
  第49回米国血液学会
- Place of Presentation
  Atlanta
- Year and Date
  2007-12-09
- Data Source
  KAKENHI-PROJECT-19591103
[Presentation] HIF-1 Supports the Survival of Multiple Myeloma Cells through the Induction of Survivin Gene2007
- Author(s)
  Kirito K
- Organizer
  第49回米国血液学会
- Place of Presentation
  Atlanta
- Year and Date
  2007-12-09
- Data Source
  KAKENHI-PROJECT-18390282
[Presentation] HIF-1 Supports the Survival of Multiple Myeloma Cells through the Induction of Survivin Gene2007
- Author(s)
  Kirito, K. Yongzhen, Hu., Yoshida, K., Mitsumori, T., Nakajima, K., Nozaki, Y., Nagashima, T., Kunitamae, M., Sakoe, K., Komatsu, N.
- Organizer
  49th Annual Meeting of American Society of Hematology
- Place of Presentation
  Atlanta, GA, USA
- Year and Date
  2007-12-09
- Data Source
  KAKENHI-PROJECT-19591103

1. KOMATSU Norio (50186798)

# of Collaborated Projects: 12 results

# of Collaborated Products: 40 results
2. UCHIDA Mie (80316520)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. MITSUMORI Toru (80377514)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
4. TSHIMA Masaki (00306151)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. KASHII Yoshifumi (10271222)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. SAKOE Kumi (10398505)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
7. 川島一郎 (20622369)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
8. KUNITAMA Masae (60397297)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. NAKAJIMA Kei (20447709)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
10. NOZAKI Yumi (80530104)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
11. MORI Masaki (00337346)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. NAGASHIMA Takahiro (10343443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 高徳正昭 (20285787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 清水律子 (40226262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 永井正 (40237483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 内田欣吾 (70213436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 須丸公雄 (40344436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SAITO Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 織谷健司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 下妻晃二郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIRITO Keita 桐戸 敬太

桐戸 敬太 キリト ケイタ

Research Projects

Research Products

Co-Researchers

GRP78の発現異常は骨髄増殖性腫瘍の血栓性病態を誘導するか？Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Enhanced ER stress response in MPN cells involved in development of myelofibrosis through secretion of GRP78Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of glucose metabolism in development of myelofibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hypoxia modulate epigenomic response in MPN cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hypoxia attenuates growth of MPN cells through suppression of SHP-2 expression and subsequent inhibition of JAK2V617F activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of glucose metabolism in hematological malignancyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Thrombopoietin (TPO) regulates HIF-la levels through generation of mitochondrial reactive oxygen speciesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

KIRITO Keita 桐戸敬太

桐戸敬太キリトケイタ