Uno Shigeyuki 宇野茂之

… Alternative Names

UNO Shigeyuki 宇野茂之

宇野茂之ウノシゲユキ

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Researcher Number	90307851
Other IDs
External Links
Affiliation (Current)	2025: 盛岡大学, 栄養学部, 教授 2025: 日本大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2018 – 2021: 日本大学, 医学部, 講師 2008 – 2011: 日本大学, 医学部, 講師 2009: 医学部, 講師 2006: 日本大学, 医学部, 講師 2004 – 2005: 日本大学, 医学部, 助手 1998 – 2000: 日本大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / General medical chemistry / Environmental pharmacy Except Principal Investigator Applied molecular and cellular biology / Biological Sciences
Keywords	Principal Investigator DAN付加体 / 導波モード / 遺伝毒性 / 導波モードセンサー / DNA付加体 / ベンゾ(a)ピレン / 脂質代謝 / 生体異物代謝 / ミトコンドリア / チトクロームP450 … More / 生体分子医学 / ベンゾ[a]ピレン / cvtochrom P450 / ベンゾ〔a〕ピレン / ベンゾ[a]ビレン / CYP1B1 / CYP1A2 / CYP1A1 / cytochrom P450 … More Except Principal Investigator plasminogen activator / TGFβ / hepatocyte / liver / PAI-1 / リトコール酸 / 転写因子 / 転写調節 / 強心ステロイド / β-カテニン / CYP1 / ビタミン / 脂質代謝 / 時計遺伝子 / 胆汁酸 / 重力 / ビタミンD / コファクター / LXR / 炎症 / 胆汁鬱滞 / CYP1A1 / ダイオキシン受容体 / ビタミンD受容体 / モーダルシフト / セルセンサー / 代謝 / 発現制御 / 脂質 / 蛋白質 / 遺伝子 / 核内受容体 Less

Elucidation of novel benzo (a) pyrene DNA adduct formation mechanism and search for genotoxicity preventive foods.Principal Investigator
- Principal Investigator
  
  UNO Shigeyuki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Nihon University
The function of mitochondrial CYP1A1 in the lipid metabolism.Principal Investigator
- Principal Investigator
  
  UNO Shigeyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Nihon University
Dynamic regulation of metabolite-sensing nuclear receptors
- Principal Investigator
  
  MAKISHIMA Makoto
- Project Period (FY)
  2006 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nihon University
環境毒性におけるCYP1ファミリーの役割Principal Investigator
- Principal Investigator
  
  宇野茂之
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Nihon University
Regulation of the PA-plasmin cascade
- Principal Investigator
  
  SEKI Taiichiro
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Nihon University

All 2011 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation

[Journal Article] Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice.2011
- Author(s)
  Ozeki J, Uno S, Ogura M, Choi M, Maeda T, Sakurai K, Matsuo S, Amano S, Nebert DW, Makishima M.
- Journal Title
  
  Toxicology 280
  
  Pages: 10-17
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in Liver X receptor-dependent and -independent manners2010
- Author(s)
  Nunomura, S.
- Journal Title
  
  FEBS Letters 584
  
  Pages: 1143-1148
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Liver X receptors and immune regulation2010
- Author(s)
  Nunomura, S.
- Journal Title
  
  BioMolecular Concepts
  
  Volume: 1 Pages: 381-387
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Suppression of beta-catenin signaling by liver X receptor ligands2009
- Author(s)
  Uno, S.
- Journal Title
  
  Biochemical and Pharmacology 77
  
  Pages: 186-195
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Benzo[a]pyrene toxicity and inflammatory disease2009
- Author(s)
  Uno, S.
- Journal Title
  
  Current Rheumatology Reviews 5
  
  Pages: 266-271
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1 : differing responses to dietary benzo [a] pyrene as proof of principle2009
- Author(s)
  Dong H, Dalton TP, Miller ML, Chen Y, Uno S, Shi Z, Shertzer HG, Bansal S, Avadhani NG, Nebert DW
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 75(3) Pages: 555-567
- Data Source
  KAKENHI-PROJECT-21590319
[Journal Article] Vitamin D3 modulates the expression of bile acid regulatory genes and represses inflammation in bile duct-ligated mice.2009
- Author(s)
  Ogura M, Nishida S, Ishizawa M, Sakurai K, Shimizu M, Matsuo S, Amano S, Uno S, Makishima M.
- Journal Title
  
  J Pharmacol Exp Ther 328
  
  Pages: 564-570
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Suppression of beta-catenin signaling by liver X receptor ligands.2009
- Author(s)
  Uno S, Endo K, Jeong Y, Kawana K, Miyachi H, Hashimoto Y, Makishima M
- Journal Title
  
  Biochem Pharmacol 77
  
  Pages: 186-195
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages.2009
- Author(s)
  Matsunawa M, Amano Y, Endo K, Uno S, Sakaki T, Yamada S, Makishima M.
- Journal Title
  
  Toxicol Sci 10
  
  Pages: 50-58
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice ; comnarine human and mouse henatoma-derived cell lines2009
- Author(s)
  Uno, S.
- Journal Title
  
  Toxicology and Applied Pharmacology (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Suppression of beta-catenin signaling by liver X receptor ligands.2009
- Author(s)
  Uno S, Endo K, Jeong Y, Kawana K, Miyachi H, Hashimoto Y, Makishima M.
- Journal Title
  
  Biochem Pharmacol 77
  
  Pages: 186-195
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia.2008
- Author(s)
  Ishizawa M, Matsunawa M, Adachi R, Uno S, Ikeda K, Masuno H, Shimizu M, Iwasaki K, Yamada S, Makishima M
- Journal Title
  
  J Lipid Res 49
  
  Pages: 763-772
- NAID
  110007575062
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia.2008
- Author(s)
  Ishizawa M, Matsunawa M, Adachi R, Uno S, Ikeda K, Masuno H, Shimizu M, Iwasaki K, Yamada S, Makishima M.
- Journal Title
  
  J Lipid Res 49
  
  Pages: 763-772
- NAID
  110007575062
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene.2008
- Author(s)
  Endo K, Uno S, Seki T, Ariga T, Kusumi Y, Mitsumata M, Yamada S, Makishima M.
- Journal Title
  
  Toxicol Appl Pharmacol 230
  
  Pages: 135-143
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Vitamin D3 derivatives with adamantane or lactone ring side chains are cell type-selective vitamin D receptor modulators.2007
- Author(s)
  Inaba Y, Yamamoto K, Yoshimoto N, Matsunawa M, Uno S, Yamada S, Makishima M
- Journal Title
  
  Mol Pharmacol 71
  
  Pages: 1298-1311
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Vitamin D3 derivatives with adamantane or lactone ring side chains are cell type-selective vitamin D receptor modulators.2007
- Author(s)
  Inaba Y, Yamamoto K, Yoshimoto N, Matsunawa M, Uno S, Yamada S, Makishima M.
- Journal Title
  
  Mol Pharmacol 71
  
  Pages: 1298-1311
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Oral Benzo[a]pyrene in Cyp1 Knockout Mouse Lines : CYP1A1 Important in Detoxication, CYP1B1 Metabolism Required for Immune Damage Independent of Total-Body Burden and Clearance Rate.2006
- Author(s)
  Shigeyuki Uno
- Journal Title
  
  Molecular Pharmacology in press
- Data Source
  KAKENHI-PROJECT-16790089
[Journal Article] Oral Benzo[a]pyrene in Cyp1 Knockout Mouse Lines : CYP1A1 Important in Detoxication, CYP1B1 Metabolism Required for Immune Damage Independent of Total-Body Burden and Clearance Rate.2006
- Author(s)
  Shigeyuki Uno
- Journal Title
  
  Molecular Pharmacology 69・4
  
  Pages: 1103-1114
- Data Source
  KAKENHI-PROJECT-16790089
[Journal Article] Oral exposure to benzo[a]pyrene in the mouse : detoxication by inducible CYP1A1 more important than metabolic activation.2004
- Author(s)
  Shigeyuki Uno
- Journal Title
  
  Molecular Pharmacology 65・5
  
  Pages: 1225-1237
- Data Source
  KAKENHI-PROJECT-16790089
[Journal Article] The aryl hydrocarbon receptor activator benzo [a] pyrene enhances vitamin D3 catabolism in macrophages.
- Author(s)
  Matsunawa M, Amano Y, Endo K, Uno S, Sakaki T, Yamada S, Makishima M
- Journal Title
  
  Toxicol Sci (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] 生体異物代謝異常による動脈硬化発症メカニズム2010
- Author(s)
  宇野茂之
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖縄コンベンションセンター
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-21590319
[Presentation] 生体異物代謝異常による動脈硬化発症メカニズム2010
- Author(s)
  宇野茂之
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖縄
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] 活性化ビタミンD3によるAhR-CYP1A1誘導メカニズム増強作用2010
- Author(s)
  宇野茂之
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] 生体異物代謝異常による動脈硬化発症メカニズム2010
- Author(s)
  宇野茂之、遠藤香織、槇島誠
- Organizer
  第37回日本トキシコロジー学会学術年会(一般口演)
- Data Source
  KAKENHI-PROJECT-21590319
[Presentation] リガンド選択的ビタミンD受容体の機能調節2010
- Author(s)
  宇野茂之
- Organizer
  第64回日本栄養・食糧学会大会
- Place of Presentation
  徳島
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] リガンド選択的ビタミンD受容体の機能調節2010
- Author(s)
  宇野茂之
- Organizer
  第64回日本栄養・食糧学会大会
- Place of Presentation
  徳島(招待講演)
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] ベンゾ[a]ピレン代謝におけるヒトCYP1A1の役割2009
- Author(s)
  宇野茂之
- Organizer
  第2回博多シンポジウム「内・外環境と生物応答」
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] ベンゾ[a]ピレン代謝活性化を抑制するヒトCYP1A12009
- Author(s)
  宇野茂之
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] 大腸癌細胞におけるLXRによるβ-カテニンシグナル抑制作用2008
- Author(s)
  宇野茂之
- Organizer
  第482回日大医学会例会
- Place of Presentation
  東京
- Year and Date
  2008-03-01
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] 生体物代謝活性化による動脈硬化発症メカニズム2008
- Author(s)
  宇野茂之
- Organizer
  第31回日本分子生物学会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] オキシステロール受容体によるコレステロール代謝調節および細胞増殖抑制作用機序2008
- Author(s)
  宇野茂之
- Organizer
  第29回日本肥満学会
- Place of Presentation
  大分
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] ベンゾ[a]ピレン(BaP)誘導性胎児毒性を抑制するCYP1A12007
- Author(s)
  宇野茂之
- Organizer
  第30回日本分子生物学会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PLANNED-18077005

1. MAKISHIMA Makoto (70346146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. YAMADA Sachiko (10014078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. NISHIDA Shigeru (90211458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. CHOI Mihwa (30571012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. ENDO Kaori (10445744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. CHO Yoshitake (70468742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. SEKI Taiichiro (20187834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ARIGA Toyohiko (50096757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ISHIZAWA MICHIYASU

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. KAWANA Katsuyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. AMANO Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. OGURA Michitaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. OGEKI Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. DECLERCK Pau

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. BRUZDZINSKI キャロリン

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. GELEHRTER Th

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Uno Shigeyuki 宇野 茂之

UNO Shigeyuki 宇野 茂之

宇野 茂之 ウノ シゲユキ

Research Projects

Research Products

Co-Researchers

Elucidation of novel benzo (a) pyrene DNA adduct formation mechanism and search for genotoxicity preventive foods.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The function of mitochondrial CYP1A1 in the lipid metabolism.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dynamic regulation of metabolite-sensing nuclear receptors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

環境毒性におけるCYP1ファミリーの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of the PA-plasmin cascade

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice.2011

Author(s)

Journal Title

Data Source

[Journal Article] Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in Liver X receptor-dependent and -independent manners2010

Author(s)

Journal Title

Data Source

[Journal Article] Liver X receptors and immune regulation2010

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of beta-catenin signaling by liver X receptor ligands2009

Author(s)

Journal Title

Data Source

[Journal Article] Benzo[a]pyrene toxicity and inflammatory disease2009

Author(s)

Journal Title

Data Source

[Journal Article] Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1 : differing responses to dietary benzo [a] pyrene as proof of principle2009

Author(s)

Journal Title

Data Source

[Journal Article] Vitamin D3 modulates the expression of bile acid regulatory genes and represses inflammation in bile duct-ligated mice.2009

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of beta-catenin signaling by liver X receptor ligands.2009

Author(s)

Journal Title

Data Source

[Journal Article] The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages.2009

Author(s)

Journal Title

Data Source

[Journal Article] CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice ; comnarine human and mouse henatoma-derived cell lines2009

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of beta-catenin signaling by liver X receptor ligands.2009

Author(s)

Journal Title

Data Source

Uno Shigeyuki 宇野茂之

UNO Shigeyuki 宇野茂之

宇野茂之ウノシゲユキ