HONZAWA Shinobu 本澤忍

… Alternative Names

本澤忍ホンザワシノブ

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Researcher Number	90311547
Other IDs
External Links
Affiliation (Current)	2025: 新潟薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2006: 新潟薬科大学, 薬学部, 准教授 2003 – 2005: 帝京大学, 薬学部, 助手 2000 – 2001: 東北大学, 大学院・薬学研究科, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical pharmacy Except Principal Investigator Chemical pharmacy
Keywords	Principal Investigator 疎水相互作用 / くる病 / ラクトン / グルタミン酸 / 変異受容体 / ビタミンD / 安息香酸 / オリゴマー / 芳香族アミン化合物 / ヘリセン … More / ルイス酸 / 芳香族炭化水素 / 塩化アルミニウム / 炭素-炭素形成反応 / 二酸化炭素 … More Except Principal Investigator agonist / active vitamin D_3 / 構造活性相関 / TEI-9647 / アゴニスト / 活性型ビタミンD_3 / ビタミンDレセプター(VDR) / bone formation / structure-activity relationship / osteoporosis / modulator / 19-norvitamin D_3 / vitamin D receptor / ハイスループット評価 / 転写共役因子 / 核内受容体 / 骨形成 / 骨粗鬆症 / モジュレーター / 19-ノルビタミンD_3 / structure activity relationship / HL-60 cells / Paget's disease / antagonist / vitamin D receptor (VDR) / HL-60細胞 / Paget's骨病 / アンタゴニスト Less

ビタミンD抵抗性くる病II型関連変異受容体とビタミンD誘導体との相互作用の解明Principal Investigator
- Principal Investigator
  
  本澤忍
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences
  Teikyo University
Development of selective nuclear receptor modulators with a 2,25-modified seco-steroidal skeleton
- Principal Investigator
  
  KITTAKA Atsushi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
Design and Synthesis of Vitamin D Receptor Antagonists : Remedy for Pagets Desease
- Principal Investigator
  
  KITTAKA Atsushi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
触媒的二酸化炭素固定反応の開発Principal Investigator
- Principal Investigator
  
  本澤忍
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tohoku University

All 2007 2006 2005 2004 2003

All Journal Article

[Journal Article] Creative Synthesis of Novel Vitamin D Analogs for Health and Disease2007
- Author(s)
  Atsushi Kittaka, Nozomi Saito, Sinobu Honzawa, Kazuya Takenouchi, Seiichi Ishizuka, Tai C. Chen, Sara Peleg, Sigeaki Kato, Midori A. Arai
- Journal Title
  
  J. Steroid Biochem. Mol. Biol. doi:10.1016/j.jsbmb.2006.12.002
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Recent Results on A-Ring Modification of 1α, 25- Dihydroxyvitamin D_3 : Design and Synthesis of VDR-Agonists and Antagonists with High Biological Activity2006
- Author(s)
  Nozomi Saito, Shinobu Honzawa, Atsushi Kittaka
- Journal Title
  
  Current Topics in Medicinal Chemistry 6(12)
  
  Pages: 1273-1288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Recent Results on A-Ring Modification of 1α,25-Dihydroxyvitamin D_3 : Design and Synthesis of VDR-Agonists and Antagonists with High Biological Activity2006
- Author(s)
  N.Saito, S.Honzawa, A.Kittaka
- Journal Title
  
  Current Topics on Medicinal Chemistry 6
  
  Pages: 1273-1288
- Data Source
  KAKENHI-PROJECT-17790095
[Journal Article] Design, Synthesis and Biological Evaluation of Novel 1α, 25-Dihydroxyvitamin D_3 Analogues Possessing Aromatic Ring on 2α-Position2005
- Author(s)
  Shinobu Honzawa, et al.
- Journal Title
  
  Tetrahedron 61・47
  
  Pages: 11253-11263
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Efficient Synthesis of 2-Alkylated 1α, 25-Dihydroxy- 19-norvitamin D_3 with Julia Olefination and Its Biological Activity2005
- Author(s)
  Atsushi Kittaka, Keiichiro Ono, Nozomi Saito, Akihiro Yoshida, Shinobu Honzawa, Toshie Fujishima, Hiroaki Takayama, Midori A. Arai, Tai C. Chen
- Journal Title
  
  Anticancer Research 25
  
  Pages: 2288-2288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Design, Synthesis and Biological Evaluation of Novel lα, 25-Dihydroxyvitamin D_3 Analogues Possessing Aromatic Ring on 2α-Position2005
- Author(s)
  Shinobu Honzawa, Koshiro Hirasaka, Yasuhiro Yamamoto, Salα Peleg, Toshie Fujishima, Masaaki Kurihara, Nozomi Saito, Seishi Kishimoto, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Tetrahedron 61 (47)
  
  Pages: 11253-11263
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] 1-アルキル置換活性型ビタミンD_3誘導体の合成と生物活性2005
- Author(s)
  本澤忍ら
- Journal Title
  
  ビタミン 79・4
  
  Pages: 258-258
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Design, Synthesis and Biological Evaluation of Novel 1α,25-Dihydroxy-vitamin D_3 Analogues Possessing Aromatic Ring on 2α-Position2005
- Author(s)
  Shinobu Honzawa, et al.
- Journal Title
  
  Tetrahedron 61・47
  
  Pages: 11253-11263
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Design, synthesis and biological evaluation of novel 1α,25-dihydroxyvitamin D_3 analogues possessing aromatic ring on 2α-position2005
- Author(s)
  Shinobu Honzawa, et al.
- Journal Title
  
  Tetrahedron 61(47)
  
  Pages: 11253-11263
- Data Source
  KAKENHI-PROJECT-17790095
[Journal Article] 1-アルキル置換ビタミンD_3誘導体の合成と生物活性2005
- Author(s)
  本澤忍, 他
- Journal Title
  
  ビタミン 79(4)
  
  Pages: 258-258
- Data Source
  KAKENHI-PROJECT-17790095
[Journal Article] 活性型ビタミンD_3 2α位への芳香環導入とくる病II型関連変異VDRに対する活性評価2004
- Author(s)
  本澤忍ら
- Journal Title
  
  ビタミン 78巻・4号
  
  Pages: 265-265
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Synthesis of Novel 1α, 25-Dihydroxy-19-norvitamin D_3 with an Amide Conjugate2004
- Author(s)
  Yoshitomo Suhara, Keiichiro Ono, Akihiro Yoshida, Toshie Fujishima, Nozomi Saito, Shinobu Honzawa, Seishi Kishimoto, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Heterocycles 62(1)
  
  Pages: 423-436
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Design and Efficient Synthesis of 2α-(ω-Hydroxyalkoxy)-lα, 25-dihydroxyvitamin D_3 Including 2-epi-ED-71 and Its 20-Epimers with HL-60 Cell Differentiation Activity2004
- Author(s)
  Nozomi Saito, Yoshitomo Suhara, Masaaki Kurihara, Toshie Fujishima, Shinobu Honzawa, Hitoshi Takayanagi, Toshiro Kozono, Masahiko Matsumoto, Masayuki Ohmori, Naoki Miyata, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  J Org.Chem. 69(22)
  
  Pages: 7463-7471
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] 2,2-Functionalized Analogues of 1α, 25-Dihydroxyvitamin D_3, The Potent Inducers of Cell Differentiation2004
- Author(s)
  Toshie Fujishima, Atsushi Kittaka, Masaaki Kurihara, Nozomi Saito, Shinobu Honzawa, Seishi Kishimoto, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama
- Journal Title
  
  J.Steroid Biochem.Mol.Biol. 89-90 (May)
  
  Pages: 89-92
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] くる病関連変異ビタミンD受容体に対応したリガンドの設計と合成: seco-ステロイド骨格1位の化学修飾2004
- Author(s)
  本澤忍ら
- Journal Title
  
  薬学雑誌 124巻・増刊号
  
  Pages: 209-210
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Synthesis of 2-Modified 1α,25-Dihydroxy-19-norvitamin D_3 with Julia Olefination: High Potency in Induction of Differentiation on HL-60 Cells2003
- Author(s)
  Keiichiro Ono, Akihiro Yoshida, Nozomi Saito, Toshie Fujishima, Shinobu Honzawa, Yoshitomo Suhara, Seishi Kishimoto, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  J.Org.Chem. 68(19)
  
  Pages: 7407-7415
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Concise Synthesis and Biological Activities of 2α-Alkyl- and 2α-(ω-Hydroxyalkyl)-20-epi-1α,25-Dihydroxyvitamin D_32003
- Author(s)
  Shinobu Honzawa, et al.
- Journal Title
  
  Bioorganic and Modicinal Chemistry Letters 13巻・20号
  
  Pages: 3503-3506
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Synthesis of an A-Ring Synthon of 2α-Substituted Vitamin D_3 Analogues Utilizing Grignard Reaction Towards Methyl 2,3-Anhydro-4,6-O-benzylidene-α-D-mannopyranoside2003
- Author(s)
  Shinobu Honzawa, Yasuhiro Yamamoto, Koshiro Hirasaka, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Heterocycles 61
  
  Pages: 327-338
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Concise Synthesis and Biological Activities of 2α-Alkyl-and 2α-(ω-Hydroxyalkyl)-20-epi-1α,25-Dihydroxyvitamin D_32003
- Author(s)
  Shinobu Honzawa, Yoshitomo Suhara, Ken-ichi Nihei, Nozomi Saito, Seishi Kishimoto, Toshie Fujishima, Masaaki Kurihara, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Bioorg.Med.Chem.Lett. 13(20)
  
  Pages: 3503-3506
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Synthesis of A-Rings Synthon of 2α-Sunstituted Vitamin D_3 Analogues Utilizing Grignard Reaction Towards Methyl 2,3-Anhydro-4,6-O-benzylidene-α-D-mannopyranoside2003
- Author(s)
  Shinobu Honzawa, et al.
- Journal Title
  
  Heterocycles 61巻
  
  Pages: 327-338
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590021

1. KITTAKA Atsushi (00214833)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. SAITO Nozomi (80349258)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. ARAI Midori (40373261)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. SUGIYAMA Toru (40242036)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAKANO Masashi (50386611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 藤島利江 (90286980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

HONZAWA Shinobu 本澤 忍

本澤 忍 ホンザワ シノブ

Research Projects

Research Products

Co-Researchers

ビタミンD抵抗性くる病II型関連変異受容体とビタミンD誘導体との相互作用の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of selective nuclear receptor modulators with a 2,25-modified seco-steroidal skeleton

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design and Synthesis of Vitamin D Receptor Antagonists : Remedy for Pagets Desease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

触媒的二酸化炭素固定反応の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Creative Synthesis of Novel Vitamin D Analogs for Health and Disease2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Recent Results on A-Ring Modification of 1α, 25- Dihydroxyvitamin D_3 : Design and Synthesis of VDR-Agonists and Antagonists with High Biological Activity2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Recent Results on A-Ring Modification of 1α,25-Dihydroxyvitamin D_3 : Design and Synthesis of VDR-Agonists and Antagonists with High Biological Activity2006

Author(s)

Journal Title

Data Source

[Journal Article] Design, Synthesis and Biological Evaluation of Novel 1α, 25-Dihydroxyvitamin D_3 Analogues Possessing Aromatic Ring on 2α-Position2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Efficient Synthesis of 2-Alkylated 1α, 25-Dihydroxy- 19-norvitamin D_3 with Julia Olefination and Its Biological Activity2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Design, Synthesis and Biological Evaluation of Novel lα, 25-Dihydroxyvitamin D_3 Analogues Possessing Aromatic Ring on 2α-Position2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] 1-アルキル置換活性型ビタミンD_3誘導体の合成と生物活性2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Design, Synthesis and Biological Evaluation of Novel 1α,25-Dihydroxy-vitamin D_3 Analogues Possessing Aromatic Ring on 2α-Position2005

Author(s)

Journal Title

Data Source

[Journal Article] Design, synthesis and biological evaluation of novel 1α,25-dihydroxyvitamin D_3 analogues possessing aromatic ring on 2α-position2005

Author(s)

Journal Title

Data Source

[Journal Article] 1-アルキル置換ビタミンD_3誘導体の合成と生物活性2005

Author(s)

Journal Title

Data Source

[Journal Article] 活性型ビタミンD_3 2α位への芳香環導入とくる病II型関連変異VDRに対する活性評価2004

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of Novel 1α, 25-Dihydroxy-19-norvitamin D_3 with an Amide Conjugate2004

HONZAWA Shinobu 本澤忍

本澤忍ホンザワシノブ