Yasuhira Shinji 安平進士

… Alternative Names

安平進士ヤスヒラシンジ

YASUHIRA Shinji 安平進士

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Researcher Number	90311729
Other IDs
Affiliation (Current)	2025: 岩手医科大学, 医歯薬総合研究所, 講師
Affiliation (based on the past Project Information) *help	2020 – 2023: 岩手医科大学, 医歯薬総合研究所, 講師 2013 – 2015: 岩手医科大学, 医学部, 助教 1999 – 2003: 京都大学, 原子炉実験所, 助手
Review Section/Research Field	Principal Investigator Basic Section 49020:Human pathology-related / Human pathology / Molecular biology Except Principal Investigator 環境影響評価(含放射線生物学) / Basic Section 49020:Human pathology-related / Radiation science / Human pathology / Risk sciences of radiation/Chemicals
Keywords	Principal Investigator 悪性黒色腫 / MAPキナーゼ / ゼブラフィッシュ / シグナル伝達 / 二重特異性フォスファターゼ / MAPK経路 / 細胞老化 / 分裂死 / 分裂期崩壊 / アポトーシス … More / 分裂攪乱 / 細胞分裂 / 遺伝子病理診断学 / DNA複製 / 分裂酵母 / 接合型変換 / DNA修復 / 相同組換え / DNA復製 … More Except Principal Investigator DNA二重鎖切断 / ニワトリ細胞株 / p53 status / non-homologous end-joining / homologous recombination / sublethal damage repair / DNA double-strand break / 相同組換え修復 / MITF / BRAF / BRAF-MAPK / MAPK / JUN / DUSP6 / DUSP4 / 悪性黒色腫 / low dose rate effects / knockout mutant / 非相同端末結合修復 / 低線量率照射 / mild temperature hyperthermia / bioreductive agent / neutron capture therapy / γ-rays / micronucleus / apoptosis / quiescent cell / 熱中性子捕捉化合物 / p53status / 原子炉中性子線照射 / 低温度温熱処理 / 低温度温熱処置 / 生体還元物質 / 中性子捕捉療法 / γ線照射 / アポトーシス / 微小核 / 休止期腫瘍細胞 / Knockout mutant / エルカインド回復 / DT40 / 潜在致死傷害回復 / 分割照射回復 / 端末結合修復 / 相同組換修復 / DNA2重鎖切断 / ニワトリ白血病細胞株 / 転移 / 大腸癌 / RhoGDI2 / 大腸癌の進展 / RBE / LET / 過酸化水素 Less

Double negative regulation of ERK activity by dual-specificity phosphatases and its role in melanomagenesisPrincipal Investigator
- Principal Investigator
  
  安平進士
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Iwate Medical University
Research on signal transduction inhibitors and novel molecules with synthetic lethal effects in melanoma
- Principal Investigator
  
  Maesawa Chihaya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Iwate Medical University
Effect of RhoGDI2 expression on progression of colon cancer
- Principal Investigator
  
  Oikawa Hiroki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Mechanism for natural resistance of melanoma cells against anti-tubulin drugsPrincipal Investigator
- Principal Investigator
  
  Yasuhira Shinji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
LET増加に伴うRBEの上昇はDNA二重鎖切断のエラー修復で説明できるか
- Principal Investigator
  
  内海博司
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyoto University
Role of DNA double-strand break repair on low dose rate effects
- Principal Investigator
  
  UTSUMI Hiroshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  KYOTO UNIVERSITY
低線量放射線と酸化的代謝による傷害とは同じか違うか
- Principal Investigator
  
  UTSUMI Hiroshi
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Kyoto University
Detection of the responses of various gene products within lntratumor quiescent tumor cells to DNA-damaging treatments
- Principal Investigator
  
  MASUNAGA Shin-ichiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  KYOTO UNIVERSITY
真核生物DNA複製における体細胞相同組換えの役割Principal Investigator
- Principal Investigator
  
  安平進士
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Kyoto University
DNA repair research using DNA double-strand break repair-gene knockout mutants
- Principal Investigator
  
  UTSUMI Hiroshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  KYOTO UNIVERSITY

All 2022 2021 2016 2015 2014

All Journal Article Presentation

[Journal Article] DUSP4 Inactivation Leads to Reduced Extracellular Signal?Regulated Kinase Activity through Upregulation of DUSP6 in Melanoma Cells2022
- Author(s)
  Kamada Hirofumi、Yasuhira Shinji、Shibazaki Masahiko、Amano Hiroo、Maesawa Chihaya
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: in press Issue: 9 Pages: 126-9
- DOI
  10.1016/j.jid.2022.02.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07377, KAKENHI-PROJECT-21K06892, KAKENHI-PROJECT-21K06907
[Journal Article] NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.2016
- Author(s)
  Kasai S, Arakawa N, Okubo A, Shigeeda W, Yasuhira S, Masuda T, Akasaka T, Shibazaki M, Maesawa C.
- Journal Title
  
  PLoS One.
  
  Volume: 11 Issue: 4 Pages: e0153181-e0153181
- DOI
  10.1371/journal.pone.0153181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08353, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462, KAKENHI-PROJECT-26860243
[Journal Article] NAD(P)H dehydrogenase, quinone 1 (NQO1), protects melanin-producing cells from cytotoxicity of rhododendrol.2016
- Author(s)
  Okubo A, Yasuhira S, Shibazaki M, Takahashi K, Akasaka T, Masuda T, Maesawa C.
- Journal Title
  
  Pigment Cell Melanoma Res.
  
  Volume: 29 Issue: 3 Pages: 309-16
- DOI
  10.1111/pcmr.12461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08353, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462
[Journal Article] Tatemichi Y, Shibazaki M, Yasuhira S, Kasai S, Tada H, Oikawa H, Suzuki Y, Takikawa Y, Masuda T, Maesawa C.2015
- Author(s)
  Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification.
- Journal Title
  
  Cancer Sci.
  
  Volume: 106 Issue: 7 Pages: 848-56
- DOI
  10.1111/cas.12680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08353, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462
[Journal Article] Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.2014
- Author(s)
  Miura S, Maesawa C, Shibazaki M, Yasuhira S, Kasai S, Tsunoda K, Maeda F, Takahashi K, Akasaka T, Masuda T. Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.
- Journal Title
  
  Am J Dermatopathol
  
  Volume: 36(3) Issue: 3 Pages: 211-216
- DOI
  10.1097/dad.0b013e3182964e02
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590431, KAKENHI-PROJECT-24590489, KAKENHI-PROJECT-24659283, KAKENHI-PROJECT-24791171, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462, KAKENHI-PROJECT-25860964, KAKENHI-PROJECT-26860891
[Presentation] メラノーマ細胞株におけるフォスファターゼ二重抑制系によるERK活性維持機構2021
- Author(s)
  鎌田啓文、安平進士、柴崎晶彦、天野博雄、前沢千早
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06892
[Presentation] パクリタキセル処理後のacuteな細胞死と細胞増殖能消失の関係2015
- Author(s)
  安平進士, 柴崎昌彦, 前沢千早
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド(神戸市)
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25460462

1. TANO Keizo (00183468)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. UTSUMI Hiroshi (20025646)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. Maesawa Chihaya (10326647)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
4. Oikawa Hiroki (50285582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Masuda Tomoyuki (10199698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. Shibazaki Akihiko (20445109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. Kasai Shyuya (20609664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Otsuka Koki (50316387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. AKASAKA Toshihide (30137525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SUGIYAMA Toru (40162903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MASUNAGA Shin-ichiro (80238914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. IMAHORI Yoshio (80191899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TACHIBANA Akira (20188262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 天野博雄 (70302487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Yasuhira Shinji 安平 進士

安平 進士 ヤスヒラ シンジ

YASUHIRA Shinji 安平 進士

Research Projects

Research Products

Co-Researchers

Double negative regulation of ERK activity by dual-specificity phosphatases and its role in melanomagenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on signal transduction inhibitors and novel molecules with synthetic lethal effects in melanoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effect of RhoGDI2 expression on progression of colon cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism for natural resistance of melanoma cells against anti-tubulin drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

LET増加に伴うRBEの上昇はDNA二重鎖切断のエラー修復で説明できるか

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of DNA double-strand break repair on low dose rate effects

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

低線量放射線と酸化的代謝による傷害とは同じか違うか

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Detection of the responses of various gene products within lntratumor quiescent tumor cells to DNA-damaging treatments

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

真核生物DNA複製における体細胞相同組換えの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNA repair research using DNA double-strand break repair-gene knockout mutants

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] DUSP4 Inactivation Leads to Reduced Extracellular Signal?Regulated Kinase Activity through Upregulation of DUSP6 in Melanoma Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NAD(P)H dehydrogenase, quinone 1 (NQO1), protects melanin-producing cells from cytotoxicity of rhododendrol.2016

Author(s)

Journal Title

DOI

Yasuhira Shinji 安平進士

安平進士ヤスヒラシンジ

YASUHIRA Shinji 安平進士