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Yasuhira Shinji  安平 進士

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安平 進士  ヤスヒラ シンジ

YASUHIRA Shinji  安平 進士

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Researcher Number 90311729
Other IDs
Affiliation (Current) 2025: 岩手医科大学, 医歯薬総合研究所, 講師
Affiliation (based on the past Project Information) *help 2020 – 2023: 岩手医科大学, 医歯薬総合研究所, 講師
2013 – 2015: 岩手医科大学, 医学部, 助教
1999 – 2003: 京都大学, 原子炉実験所, 助手
Review Section/Research Field
Principal Investigator
Basic Section 49020:Human pathology-related / Human pathology / Molecular biology
Except Principal Investigator
環境影響評価(含放射線生物学) / Basic Section 49020:Human pathology-related / Radiation science / Human pathology / Risk sciences of radiation/Chemicals
Keywords
Principal Investigator
悪性黒色腫 / MAPキナーゼ / ゼブラフィッシュ / シグナル伝達 / 二重特異性フォスファターゼ / MAPK経路 / 細胞老化 / 分裂死 / 分裂期崩壊 / アポトーシス … More / 分裂攪乱 / 細胞分裂 / 遺伝子病理診断学 / DNA複製 / 分裂酵母 / 接合型変換 / DNA修復 / 相同組換え / DNA復製 … More
Except Principal Investigator
DNA二重鎖切断 / ニワトリ細胞株 / p53 status / non-homologous end-joining / homologous recombination / sublethal damage repair / DNA double-strand break / 相同組換え修復 / MITF / BRAF / BRAF-MAPK / MAPK / JUN / DUSP6 / DUSP4 / 悪性黒色腫 / low dose rate effects / knockout mutant / 非相同端末結合修復 / 低線量率照射 / mild temperature hyperthermia / bioreductive agent / neutron capture therapy / γ-rays / micronucleus / apoptosis / quiescent cell / 熱中性子捕捉化合物 / p53status / 原子炉中性子線照射 / 低温度温熱処理 / 低温度温熱処置 / 生体還元物質 / 中性子捕捉療法 / γ線照射 / アポトーシス / 微小核 / 休止期腫瘍細胞 / Knockout mutant / エルカインド回復 / DT40 / 潜在致死傷害回復 / 分割照射回復 / 端末結合修復 / 相同組換修復 / DNA2重鎖切断 / ニワトリ白血病細胞株 / 転移 / 大腸癌 / RhoGDI2 / 大腸癌の進展 / RBE / LET / 過酸化水素 Less
  • Research Projects

    (10 results)
  • Research Products

    (7 results)
  • Co-Researchers

    (14 People)
  •  Double negative regulation of ERK activity by dual-specificity phosphatases and its role in melanomagenesisPrincipal Investigator

    • Principal Investigator
      安平 進士
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Iwate Medical University
  •  Research on signal transduction inhibitors and novel molecules with synthetic lethal effects in melanoma

    • Principal Investigator
      Maesawa Chihaya
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Iwate Medical University
  •  Effect of RhoGDI2 expression on progression of colon cancer

    • Principal Investigator
      Oikawa Hiroki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Iwate Medical University
  •  Mechanism for natural resistance of melanoma cells against anti-tubulin drugsPrincipal Investigator

    • Principal Investigator
      Yasuhira Shinji
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Iwate Medical University
  •  LET増加に伴うRBEの上昇はDNA二重鎖切断のエラー修復で説明できるか

    • Principal Investigator
      内海 博司
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Kyoto University
  •  Role of DNA double-strand break repair on low dose rate effects

    • Principal Investigator
      UTSUMI Hiroshi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      KYOTO UNIVERSITY
  •  低線量放射線と酸化的代謝による傷害とは同じか違うか

    • Principal Investigator
      UTSUMI Hiroshi
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      Kyoto University
  •  Detection of the responses of various gene products within lntratumor quiescent tumor cells to DNA-damaging treatments

    • Principal Investigator
      MASUNAGA Shin-ichiro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      KYOTO UNIVERSITY
  •  真核生物DNA複製における体細胞相同組換えの役割Principal Investigator

    • Principal Investigator
      安平 進士
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Molecular biology
    • Research Institution
      Kyoto University
  •  DNA repair research using DNA double-strand break repair-gene knockout mutants

    • Principal Investigator
      UTSUMI Hiroshi
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      KYOTO UNIVERSITY

All 2022 2021 2016 2015 2014

All Journal Article Presentation

  • [Journal Article] DUSP4 Inactivation Leads to Reduced Extracellular Signal?Regulated Kinase Activity through Upregulation of DUSP6 in Melanoma Cells2022

    • Author(s)
      Kamada Hirofumi、Yasuhira Shinji、Shibazaki Masahiko、Amano Hiroo、Maesawa Chihaya
    • Journal Title

      Journal of Investigative Dermatology

      Volume: in press Issue: 9 Pages: 126-9

    • DOI

      10.1016/j.jid.2022.02.007

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07377, KAKENHI-PROJECT-21K06892, KAKENHI-PROJECT-21K06907
  • [Journal Article] NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.2016

    • Author(s)
      Kasai S, Arakawa N, Okubo A, Shigeeda W, Yasuhira S, Masuda T, Akasaka T, Shibazaki M, Maesawa C.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 4 Pages: e0153181-e0153181

    • DOI

      10.1371/journal.pone.0153181

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08353, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462, KAKENHI-PROJECT-26860243
  • [Journal Article] NAD(P)H dehydrogenase, quinone 1 (NQO1), protects melanin-producing cells from cytotoxicity of rhododendrol.2016

    • Author(s)
      Okubo A, Yasuhira S, Shibazaki M, Takahashi K, Akasaka T, Masuda T, Maesawa C.
    • Journal Title

      Pigment Cell Melanoma Res.

      Volume: 29 Issue: 3 Pages: 309-16

    • DOI

      10.1111/pcmr.12461

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08353, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462
  • [Journal Article] Tatemichi Y, Shibazaki M, Yasuhira S, Kasai S, Tada H, Oikawa H, Suzuki Y, Takikawa Y, Masuda T, Maesawa C.2015

    • Author(s)
      Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification.
    • Journal Title

      Cancer Sci.

      Volume: 106 Issue: 7 Pages: 848-56

    • DOI

      10.1111/cas.12680

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08353, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462
  • [Journal Article] Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.2014

    • Author(s)
      Miura S, Maesawa C, Shibazaki M, Yasuhira S, Kasai S, Tsunoda K, Maeda F, Takahashi K, Akasaka T, Masuda T. Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.
    • Journal Title

      Am J Dermatopathol

      Volume: 36(3) Issue: 3 Pages: 211-216

    • DOI

      10.1097/dad.0b013e3182964e02

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23590431, KAKENHI-PROJECT-24590489, KAKENHI-PROJECT-24659283, KAKENHI-PROJECT-24791171, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462, KAKENHI-PROJECT-25860964, KAKENHI-PROJECT-26860891
  • [Presentation] メラノーマ細胞株におけるフォスファターゼ二重抑制系によるERK活性維持機構2021

    • Author(s)
      鎌田 啓文、安平 進士、柴崎 晶彦、天野 博雄、前沢 千早
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-21K06892
  • [Presentation] パクリタキセル処理後のacuteな細胞死と細胞増殖能消失の関係2015

    • Author(s)
      安平 進士, 柴崎 昌彦, 前沢 千早
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PROJECT-25460462
  • 1.  TANO Keizo (00183468)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  UTSUMI Hiroshi (20025646)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  Maesawa Chihaya (10326647)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 4.  Oikawa Hiroki (50285582)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  Masuda Tomoyuki (10199698)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  Shibazaki Akihiko (20445109)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  Kasai Shyuya (20609664)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  Otsuka Koki (50316387)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  AKASAKA Toshihide (30137525)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  SUGIYAMA Toru (40162903)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  MASUNAGA Shin-ichiro (80238914)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  IMAHORI Yoshio (80191899)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TACHIBANA Akira (20188262)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  天野 博雄 (70302487)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

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